SGTCid condition conc unit SPN1|YPR133C.score SPN1|YPR133C.strain.pval SPN1|YPR133C.strain.significant SPN1|YPR133C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2471 5466956 24.79 µM 11.7511662739251 3.12811691231158e-20 yes 1 3.48254218506545e-32 3 724419 SGTC_309 k408-0051 1.48 µM 9.98848132303622 4.12532188169766e-15 yes 2 8.55921125121605e-24 2 3640463 SGTC_2733 amorolfine 100 µM 9.32499828867004 2.15130496831657e-13 yes 3 5.54926920825333e-21 2 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2337 9009472 200 µM 8.39388318879069 3.54462647683422e-11 yes 4 2.35171728935512e-17 1 5742383 SGTC_2475 5812728 15.03 µM 7.62246353625615 1.64427923177127e-09 yes 5 1.24439719272561e-14 6 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2799 7812892 81.82 µM 7.60505522152158 1.78568741691143e-09 yes 6 1.42391134004384e-14 4 20205235 SGTC_2980 9014342 25.29 µM 7.52237334334068 2.63580632745878e-09 yes 7 2.68953592083024e-14 6 2996599 SGTC_262 fenpropimorph 62.5 µM 6.85346317288112 5.29956078655269e-08 yes 8 3.60416076491843e-12 5 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2576 guaiol 23.12 µM 6.35780384167776 4.12885407993817e-07 yes 9 1.02329290154776e-10 1 227829 SGTC_1718 roemerine 11.9335 µM 6.35523411707129 4.17145853737897e-07 yes 10 1.04054709491127e-10 7 235224 An aporphine alkaloid with mutagenic activity. SGTC_1271 0832-2808 169 µM 6.35262929883474 4.21507678229202e-07 yes 11 1.0583268837028e-10 3 3663794 SGTC_1785 bathophenanthroline 24 µM 6.29218188831914 5.35984854095419e-07 yes 12 1.56517186655247e-10 7 72812 An iron chelator. SGTC_3085 9117376 49.47 µM 5.59201780200998 7.41083739933801e-06 yes 13 1.12222900519478e-08 2 16480349 SGTC_947 3447-0010 211 µM 5.50549809833304 1.00500705036699e-05 yes 14 1.84062967190467e-08 1 748350 SGTC_2968 9090663 33.37 µM 5.42172632439375 1.34418997287879e-05 yes 15 2.95131013273544e-08 5 25236811 SGTC_2798 7813637 45.45 µM 5.37961298959411 1.55338078197123e-05 yes 16 3.7323066548911e-08 5 956368 SGTC_2438 5259590 200 µM 5.35362381526832 1.69753999341633e-05 yes 17 4.3104998151457e-08 2 1201127 SGTC_2296 7971656 126.45 µM 5.31253660071211 1.95165907973473e-05 yes 18 5.40548519576724e-08 5 666570 SGTC_969 1313-0238 134 µM 5.25541423845184 2.36549925042523e-05 yes 19 7.38458325940674e-08 9 5212874 SGTC_775 4577-0580 57.3 µM 5.00034109182633 5.45526331535087e-05 yes 20 2.86144896194654e-07 2 2006902 SGTC_302 1094-0063 18.9 µM 4.85519902018691 8.62968314477809e-05 yes 21 6.01329470716359e-07 9 5440289 SGTC_2541 muurolladie-3-one 83.07 µM 4.83127586411584 9.29643714700409e-05 yes 22 6.7830440771263e-07 13 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_104 0074-0074 590.992 µM 4.74710271634575 0.000120475342481249 yes 23 1.03175586280573e-06 8 3943124 SGTC_584 0986-0246 15.4 µM 4.71033949922968 0.000134744684124651 yes 24 1.23652244680317e-06 14 53315 YDR232W HEM1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 4.62878310921198 0.00017224581223694 yes 25 1.83910377814667e-06 9 1377 SGTC_2802 7925815 54.55 µM 4.58530768964597 0.000196026112513194 yes 26 2.26659177954263e-06 6 1262923 SGTC_258 haloperidol 50.781 µM 4.50291471245622 0.000249724210502379 yes 27 3.35138937828809e-06 14 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1520 flindersine 88 µM 4.48553354947592 0.000262679009686544 yes 28 3.63658502699627e-06 7 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2725 haloperidol 53.21 µM 4.46115688298859 0.000281905419577108 yes 29 4.0759191971091e-06 14 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_795 0685-0265 78 µM 4.44271813139662 0.000297310464703589 yes 30 4.44147514511896e-06 10 302754 SGTC_287 k060-0039 29.6 µM 4.41873383038358 0.000318522169059453 yes 31 4.96404134381282e-06 6 5861974 SGTC_1732 st034308 51.822 µM 4.39330544657329 0.000342542672742725 yes 32 5.5820049301524e-06 5 830119 SGTC_882 0843-0131 351 µM 4.21705838637273 0.000561235075266823 yes 33 1.2375495297816e-05 10 5425421 SGTC_1953 st076800 12.1 µM 4.21297354139225 0.00056757485607284 yes 34 1.2601529804652e-05 14 297591 SGTC_851 0394-0702 453 µM 4.1713066055067 0.000636132727899417 yes 35 1.51429015973368e-05 19 762646 SGTC_2459 5811157 9.22 µM 4.16925670882321 0.000639695221213005 yes 36 1.52797316601131e-05 7 2870684 YBR192W RIM2 SGTC_2606 farnesol 9.78 µM 4.15441637798438 0.000666040477446129 yes 37 1.63059426122554e-05 10 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_67 0335-0847 266 µM 4.10870984049962 0.000753599813816199 yes 38 1.98937795017712e-05 19 4552207 YOR254C SEC63 SGTC_2785 7756463 72.73 µM 4.09355930617058 0.000784886803365017 yes 39 2.12400678620947e-05 15 2201551 SGTC_2719 novobiocin 32.65 µM 4.09091776922606 0.000790462684482739 yes 40 2.14834735142217e-05 1 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3217 9129673 49.47 µM 4.03816056945864 0.000909748746328415 yes 41 2.69359870365646e-05 8 17248312 SGTC_213 1246-0773 967 nM 3.98921075870461 0.00103500297551373 no 42 3.31467503429755e-05 2 6251622 SGTC_3099 9120367 49.47 µM 3.9634674171686 0.00110704712038947 no 43 3.69344747865979e-05 2 24824940 SGTC_1108 betulinic acid 729.144 nM 3.96092928075731 0.00111439361554794 no 44 3.73293217310601e-05 4 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1469 k284-2957 126 µM 3.83383948272327 0.00154469535699151 no 45 6.30792420170605e-05 14 23884841 SGTC_1154 4088-0362 150 µM 3.81656947296548 0.00161363691136799 no 46 6.76599930062449e-05 11 6618304 SGTC_3145 9085516 49.47 µM 3.81106264678778 0.00163620258645995 no 47 6.91853459736248e-05 15 25236195 SGTC_730 1436-0052 41.2 µM 3.79757480237209 0.00169269203930371 no 48 7.30593447728866e-05 16 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2546 rhodinyl acetate 100 µM 3.7941016806472 0.00170752275468785 no 49 7.40894730435661e-05 8 6708682 SGTC_921 1561-0023 372 µM 3.72390998335632 0.00203375616801257 no 50 9.80804464583034e-05 8 24050882 SGTC_545 4218-0007 221 µM 3.7143727211747 0.00208220259954113 no 51 0.000101854183016888 9 2840508 SGTC_2061 5245884 80.95 µM 3.71376708362156 0.00208531412797191 no 52 0.000102098371654452 9 573863 SGTC_769 0302-0231 76 µM 3.6794303915137 0.00226877536887861 no 53 0.000116877740405798 14 571869 YER009W NTF2 SGTC_911 3456-4043 236 µM 3.65786643863008 0.00239134348631764 no 54 0.000127161753874564 16 914281 SGTC_115 0527-0192 112.043 µM 3.61093392072586 0.00267905517295994 no 55 0.000152548197443919 31 4233931 SGTC_282 k297-0036 65.7 µM 3.59151987771897 0.0028069468778421 no 56 0.000164377548004666 5 5061378 SGTC_853 0419-0306 21 µM 3.59063686460405 0.0028128926444094 no 57 0.000164935478978268 9 762713 SGTC_2806 7952793 58.44 µM 3.58102805511832 0.00287833196391011 no 58 0.000171122449064333 9 2972490 SGTC_3075 9116269 49.47 µM 3.57767275979573 0.00290150406851392 no 59 0.000173333543047267 12 17015205 YNL244C SUI1 SGTC_2873 9040596 71.43 µM 3.56450040280067 0.00299410903261031 no 60 0.000182274945868771 10 6463863 SGTC_2024 5144227 134 µM 3.55749311282101 0.00304444962812413 no 61 0.000187205457301852 8 3475211 SGTC_2445 5742597 35.57 µM 3.52664974275128 0.00327521217404861 no 62 0.000210426553208733 11 1774255 SGTC_1719 st032227 49.2 µM 3.52324807762477 0.00330160243269367 no 63 0.000213146071863362 13 3125804 SGTC_630 4356-0227 183 µM 3.51594731239174 0.00335888866107211 no 64 0.000219093966044495 7 779312 SGTC_541 4513-1321 94 µM 3.50162916782021 0.00347383845936501 no 65 0.000231211378865881 14 747515 SGTC_3346 9158254 43.5805 µM 3.48553096500314 0.00360728878326306 no 66 0.000245580686724888 20 17639500 SGTC_2727 riluzole 51.77 µM 3.46988918689957 0.00374134430802009 no 67 0.000260336565656203 8 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3013 9080133 71.4286 µM 3.4659847444318 0.00377549598897778 no 68 0.000264146627229723 5 17050193 SGTC_1604 st002052 72.4 µM 3.46417190776543 0.00379144745700553 no 69 0.000265933250125389 12 6254834 YHR062C RPP1 SGTC_2408 sulbentine 18.36 µM 3.41820757452927 0.00421661508604578 no 70 0.000315175065806514 47 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1003 4049-0218 100 µM 3.40524824027056 0.00434395671474914 no 71 0.000330519669513076 14 295161 SGTC_1944 st076371 56.9 µM 3.40475719276934 0.00434884874737363 no 72 0.000331114535393687 7 24208455 SGTC_3134 9127454 49.47 µM 3.38687627406582 0.00453037416025598 no 73 0.000353466306171014 4 24262820 SGTC_2549 cedrol 20.94 µM 3.37618352054453 0.00464213055989553 no 74 0.00036749437871331 21 6708665 A sedative which affects the nervous system. SGTC_1681 tripelennamine 100 µM 3.37496759127094 0.00465499347958552 no 75 0.000369121920610391 16 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_461 N-acetylfarnesylcysteine 136 µM 3.35959900403754 0.00482033562127457 no 76 0.000390278389608162 1 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_45 0kpi-0036 14.9 µM 3.31421667698792 0.00533955037423143 no 77 0.000459501309425639 11 2795021 SGTC_2467 5474540 200 µM 3.31276929105983 0.00535689854988694 no 78 0.000461885736465134 12 5413519 SGTC_2520 obtusaquinone 4.71 µM 3.30971130898295 0.00539371600007317 no 79 0.000466961209413645 12 5967872 SGTC_2624 nerol 100 µM 3.29950948943051 0.00551817607866582 no 80 0.000484269764834669 8 637566 A natural product oil. SGTC_170 4197-0004 226 µM 3.29420420704853 0.00558390254772412 no 81 0.000493503824458774 12 218692 SGTC_1087 pterostilbene 9.05 µM 3.29110171083379 0.00562266036042237 no 82 0.000498979118371016 11 5281727 Similar to reservatol, lowers cholesterol. SGTC_2508 celastrol 40.54 µM 3.28732316647196 0.00567018619827528 no 83 0.000505723448693257 7 122724 Celastrol is a natural product and antioxidant. SGTC_2907 7721985 69.9 µM 3.28117612298174 0.00574826492628836 no 84 0.000516875857621567 12 3267881 SGTC_3208 9114115 49.47 µM 3.26566573728577 0.00594953219189673 no 85 0.000546035384401061 23 650895 SGTC_927 2425-1185 123 µM 3.26418454026262 0.00596907568241747 no 86 0.000548898184233097 10 730375 SGTC_1860 st056228 74.6 µM 3.25654347698419 0.00607080176705133 no 87 0.000563888287551121 12 688679 SGTC_2448 5185112 27.17 µM 3.24214726942715 0.0062666411644105 no 88 0.000593163507243042 11 5718189 SGTC_2315 7733312 200 µM 3.24003271901427 0.00629587282499159 no 89 0.000597579923476885 16 726316 SGTC_2279 7948423 32.93 µM 3.23704511621328 0.00633737936960409 no 90 0.000603871580294581 12 1247112 SGTC_1276 0871-0068 94.2 µM 3.20669091698705 0.00677301592213876 no 91 0.000671355877293896 12 3414906 SGTC_2581 avocatin a 64 µM 3.20447217746458 0.0068058726584083 no 92 0.000676551837147617 14 6710728 A skin care supplement. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 3.19718516886325 0.00691477685161509 no 93 0.00069387904930267 16 368090 SGTC_3198 9112019 49.47 µM 3.18199275993373 0.00714678703653021 no 94 0.00073132737400237 9 45595555 SGTC_285 1486-1325 46 µM 3.18193075948226 0.00714774777549531 no 95 0.000731483946335214 13 22310230 SGTC_3113 9123498 49.47 µM 3.17710095732509 0.00722293983538232 no 96 0.000743776215705262 13 8897275 SGTC_66 0109-0187 42.4 µM 3.16601642059745 0.00739815085593245 no 97 0.000772710346996422 13 759417 SGTC_1354 1498-1681 81 µM 3.15072902929155 0.00764593658698204 no 98 0.000814317554023575 17 5754243 SGTC_2936 9038235 15.59 µM 3.1281761002121 0.00802482398305114 no 99 0.00087947380004114 20 4749415 SGTC_1749 st037932 54.2 µM 3.11905367113378 0.00818270812116747 no 100 0.000907164545203773 21 594497 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 3.08552355045083 0.00878671420541068 no 101 0.00101597065977657 17 165521 SGTC_355 1311-2252 105 µM 3.06654690315813 0.00914559248040258 no 102 0.00108273415717146 11 5338538 SGTC_3055 9094636 49.47 µM 3.05026950035533 0.00946358260199122 no 103 0.00114318052065502 18 25236176 SGTC_776 4476-4378 112 µM 3.04414599432274 0.00958568876591284 no 104 0.00116670936239625 10 2892008 SGTC_654 1124-0271 80.9 µM 3.04274681069064 0.0096137817951503 no 105 0.00117214742774889 20 5403748 SGTC_933 2914-0560 114 µM 3.01772217080506 0.010128522697957 no 106 0.00127341139367326 18 463887 SGTC_2265 7929201 200 µM 3.01355301025375 0.0102165767987078 no 107 0.00129103963572644 14 1265108 SGTC_800 3448-7362 155 µM 3.01167893223303 0.0102563750066934 no 108 0.001299036162137 74 15991913 SGTC_3286 9117135 37.221 µM 3.01062940932756 0.010278721842322 no 109 0.00130353414067056 21 3438150 SGTC_349 k015-0014 24 µM 3.00737968804425 0.0103481856174366 no 110 0.00131755204420474 16 2196908 SGTC_2565 isoliquiritigenin 100 µM 3.00525336458346 0.0103938576134195 no 111 0.00132679852611733 25 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1545 lovastatin 49.4 µM 3.0051633696229 0.0103957945143193 no 112 0.00132719118127241 22 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_872 0588-0139 234 µM 2.98927309815017 0.0107427605485697 no 113 0.0013982103078205 11 2047100 SGTC_2972 9093619 59.92 µM 2.98465399838151 0.0108454921954629 no 114 0.00141949627419473 15 25236256 SGTC_721 1187-1332 279 µM 2.98068239372953 0.0109345057762651 no 115 0.00143803454632817 21 25730 SGTC_2477 5967686 25.23 µM 2.96587538186216 0.0112719943385041 no 116 0.00150911380256097 18 776118 SGTC_25 0118-0223 35.662 µM 2.95072845934535 0.0116265622511358 no 117 0.00158512746518662 9 5333628 SGTC_849 0386-0493 241 µM 2.94847757543708 0.0116800701851055 no 118 0.0015967165347909 15 726119 SGTC_1342 1486-1464 234 µM 2.94305648376188 0.0118098183666463 no 119 0.00162494558683289 12 3253938 SGTC_416 estradiol valerate 100 µM 2.8848482149495 0.0132836594903993 no 120 0.00195801208489554 15 13791 A steroid. SGTC_713 1488-1073 324 µM 2.87833506436227 0.0134580623390417 no 121 0.00199890135837651 11 3312542 SGTC_2993 9054257 71.4286 µM 2.87360686019734 0.013585904862597 no 122 0.00202906883744709 54 6470217 YGL055W OLE1 SGTC_299 1273-0059 1.44 µM 2.87134695118992 0.0136473782166944 no 123 0.00204363324993305 20 2848077 SGTC_1847 st056231 15 µM 2.85763578058604 0.0140255146394427 no 124 0.00213404992106337 20 5393180 SGTC_474 dl-dihydrosphingosine 5 µM 2.85122716180506 0.0142053310205305 no 125 0.00217754219164499 21 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3082 9117008 49.47 µM 2.82844372919073 0.0148607722904366 no 126 0.00233874616664329 8 41448529 SGTC_290 2043-6722 48.1 µM 2.82185735350039 0.015055030946848 no 127 0.00238732047712829 13 773758 YLR208W SEC13 SGTC_980 1473-0395 201 µM 2.81400935233138 0.015289345791748 no 128 0.00244639024420616 24 768876 SGTC_1647 st011722 22.4 µM 2.81182302861699 0.0153551772433234 no 129 0.00246307992879461 18 2854783 SGTC_792 4534-1957 155 µM 2.78186474011496 0.0162820437545413 no 130 0.00270237802071478 11 1717904 SGTC_655 k060-0012 42 µM 2.74411941699696 0.0175177002095465 no 131 0.00303367310432009 23 5994525 SGTC_3254 9136651 49.47 µM 2.73625190706965 0.017785101998418 no 132 0.00310717170828877 23 16454030 SGTC_2486 5283202 22.39 µM 2.71569026909108 0.018500447687686 no 133 0.00330688802555532 15 1377751 SGTC_1865 st057639 52.2 µM 2.70435535686822 0.0189051666348333 no 134 0.00342185287500812 18 688818 SGTC_1466 k213-0079 57.5 µM 2.69762050720276 0.0191491865204031 no 135 0.00349185014401908 36 3657981 SGTC_1680 diphenhydramine 100 µM 2.69494923249267 0.0192467122468027 no 136 0.00351996781778508 31 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_274 sirtinol 40.1 µM 2.68983214718056 0.0194347114010192 no 137 0.00357439832288142 31 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_134 0269-0018 6.916 µM 2.68106285242422 0.0197605185888045 no 138 0.00366943652130268 39 4378915 SGTC_2695 st077686 51.995 µM 2.67523134951259 0.0199797345668197 no 139 0.00373388488246175 16 2876092 SGTC_1047 2043-3044 82 µM 2.66274625917259 0.0204560144258129 no 140 0.0038752917127977 30 669592 SGTC_3087 9117406 49.47 µM 2.6461672545617 0.0211033095572871 no 141 0.00407047767635814 21 42546093 SGTC_1465 k213-0056 144 µM 2.64466473248981 0.0211628197607734 no 142 0.00408859465414739 35 24048857 YMR208W ERG12 SGTC_2513 baicalein 25.65 µM 2.64103560495003 0.0213071439420245 no 143 0.00413265163410045 16 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_37 0566-0070 1.56 µM 2.63569778136489 0.0215209318641342 no 144 0.00419822387309401 20 1626686 SGTC_1815 st051655 58.2 µM 2.62869217101014 0.0218042659519421 no 145 0.00428569554401208 44 5984156 SGTC_472 calcifediol 10 µM 2.62770235870178 0.0218445507071196 no 146 0.00429818477327726 11 5283731 A vitamin D metabolite. SGTC_1798 st045719 60.953 µM 2.6267590440537 0.0218830015166446 no 147 0.00431011757434628 24 3980186 SGTC_1870 st057514 26.5 µM 2.62655189410649 0.021891452884245 no 148 0.00431274195496755 27 5393161 SGTC_2002 4023503 131 µM 2.62623642220307 0.0219043288994783 no 149 0.00431674140947289 40 4736863 YCR052W RSC6 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.62622181328929 0.021904925318558 no 150 0.00431692669702083 20 2333 A French combination drug. SGTC_538 2922-0838 53.3 µM 2.62300416909401 0.0220366224330874 no 151 0.00435791030103709 26 777039 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.62225039363175 0.0220675706608157 no 152 0.00436756137504903 13 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3255 9139072 49.47 µM 2.6213957053354 0.0221027065053752 no 153 0.00437852760373623 16 17646060 SGTC_3180 9109287 49.47 µM 2.61846610705143 0.022223499456168 no 154 0.00441630327112067 41 18891271 SGTC_1697 st025554 27.742 µM 2.61042943267507 0.0225577302074577 no 155 0.00452143133276744 19 1269519 SGTC_707 0865-0008 204 µM 2.60037322397077 0.0229819097998113 no 156 0.00465612099300032 21 723043 SGTC_2964 9083345 53.42 µM 2.59034496823491 0.0234115808300001 no 157 0.00479398986680327 41 17741579 SGTC_1049 3226-0134 66 µM 2.58801479263538 0.0235123816823791 no 158 0.00482654175704539 22 5702385 SGTC_362 0310-0100 9.03 µM 2.58756204818968 0.0235320092140616 no 159 0.00483288928151645 25 790235 SGTC_2095 5432005 200 µM 2.5856502231771 0.0236150433542354 no 160 0.00485977540375734 24 783734 SGTC_681 1642-0006 26.6 µM 2.58447979212369 0.0236659988709923 no 161 0.00487630096958616 18 4446530 SGTC_523 1934-0222 13.7 µM 2.5806509974974 0.0238333344600927 no 162 0.00493071098448583 31 1361595 SGTC_2628 lathosterol 100 µM 2.57633627935775 0.0240230979345048 no 163 0.00499267404485885 28 6710616 SGTC_930 2810-3379 265 µM 2.57030816995478 0.0242903417722739 no 164 0.00508040414448202 28 1015764 SGTC_503 tyrphostin 8 294 µM 2.55212119374106 0.0251117952812504 no 165 0.00535346339056143 23 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1981 st071826 47 µM 2.55166064899322 0.0251328953947511 no 166 0.00536054426849185 24 11838600 SGTC_454 lyso-paf C-16 6.67 µM 2.55157419885625 0.0251368578117932 no 167 0.00536187436769187 26 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1641 st009299 47.1 µM 2.52188498326368 0.0265289657062352 no 168 0.00583639338653645 40 4046054 SGTC_1160 4092-0570 10.5 µM 2.52173304281152 0.0265362524899923 no 169 0.00583891472476797 34 4994975 SGTC_1288 0973-0013 65.5 µM 2.51782816195487 0.0267240978786147 no 170 0.00590404570186282 16 4315430 SGTC_2580 diallyl disulphide 81.36 µM 2.51405666672179 0.0269065797026816 no 171 0.00596756274876041 29 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2189 6047310 154.431 µM 2.5129977469459 0.0269580016180426 no 172 0.00598550497232833 20 711535 SGTC_2188 6126565 140.678 µM 2.50146237913388 0.0275235003066029 no 173 0.00618407911343736 24 874518 SGTC_2419 paclitaxel 166.5 µM 2.50000339632064 0.0275957235621328 no 174 0.00620960579430011 27 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2473 5854593 8.94 µM 2.49812686969948 0.0276888484599914 no 175 0.00624257509253728 21 2872951 SGTC_2495 cafestol 54.53 µM 2.49369382737595 0.0279098840673521 no 176 0.00632107699792999 43 16667697 An anti-infammatory. SGTC_880 0833-0487 87.2 µM 2.48590592478539 0.0283017548601927 no 177 0.00646110602718124 16 76075 SGTC_2145 5634607 200 µM 2.47331983207827 0.0289447347404557 no 178 0.00669321411636794 15 308662 SGTC_691 1548-0686 185 µM 2.46869907744285 0.0291838196797306 no 179 0.00678026000700453 50 46495133 SGTC_2478 5763493 32.33 µM 2.45869328502069 0.0297071599402202 no 180 0.00697218461438494 27 1365576 YLR208W SEC13 SGTC_1052 3253-3998 198 µM 2.45852389380181 0.0297160863293466 no 181 0.00697547463660688 26 5450317 SGTC_1255 0566-0045 221 µM 2.45741977740479 0.0297743243672865 no 182 0.00699695307580432 39 2788469 SGTC_1926 methyl fluorone black 53.6 µM 2.44326053693602 0.030529601077761 no 183 0.00727761267717354 54 72721 Reacts with homocysteine. SGTC_636 0kpi-0074 126 µM 2.44015041519983 0.0306976083909918 no 184 0.0073405738227074 25 616434 SGTC_195 4234-0266 16.654 µM 2.43823978983454 0.0308011985691328 no 185 0.00737949006602304 51 2303354 SGTC_1756 st041558 35.5 µM 2.42650173537859 0.0314439799480746 no 186 0.00762258870634118 27 3955792 SGTC_677 0929-0063 136 µM 2.41141926461037 0.0322861428049104 no 187 0.00794528479257733 16 1539583 SGTC_2731 amoxapine 43.43 µM 2.40865432037329 0.0324425307753438 no 188 0.00800572775038744 20 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1380 2291-0730 164 µM 2.39703912446925 0.0331063396015182 no 189 0.00826407939662027 24 2999191 SGTC_850 0388-0143 75.9 µM 2.39701804443406 0.0331075544230836 no 190 0.00826455485061284 24 67273 SGTC_3009 9080819 71.4286 µM 2.39594579824895 0.033169395371875 no 191 0.00828877076072775 36 17027216 SGTC_544 k015-0020 52.4 µM 2.38725503277016 0.0336741474615804 no 192 0.00848735558754856 25 3008304 SGTC_1018 4259-0013 28.1 µM 2.36663802980981 0.0348968816101478 no 193 0.00897523965516419 27 6801262 SGTC_571 k831-0106 44.2 µM 2.35485930179591 0.0356116499802401 no 194 0.00926486009688257 30 4783639 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.34975346094142 0.0359251943758601 no 195 0.00939292461236216 44 4330530 SGTC_3006 9075424 71.4286 µM 2.34587228966153 0.0361650429607486 no 196 0.0094913052402359 29 7465181 SGTC_2759 disulfiram 3.38 µM 2.34326347073612 0.0363269983934765 no 197 0.00955793933290626 56 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_640 3381-0960 37.1 µM 2.34063590634957 0.0364907171346892 no 198 0.00962546523050359 29 1745025 SGTC_69 0096-0274 206.684 µM 2.33387297448223 0.036914881315097 no 199 0.00980118712407112 88 6741392 SGTC_1804 st050076 49.1 µM 2.32392299047184 0.0375462541420328 no 200 0.0100648109095608 38 3895976 SGTC_2927 9011802 47.9 µM 2.32362822293254 0.0375650921656278 no 201 0.0100727142221835 33 43912568 SGTC_1998 st075797 76.8 µM 2.31551518698152 0.038086617173742 no 202 0.0102923772008686 31 24208315 SGTC_1363 1636-0063 10.4 µM 2.31337364066862 0.038225261664673 no 203 0.0103510525240774 37 6072185 SGTC_907 3448-6986 75.5 µM 2.31211324939828 0.0383070520629675 no 204 0.0103857216003919 40 590582 SGTC_2961 9083290 32.55 µM 2.31196276189904 0.0383168271558909 no 205 0.0103898677563108 21 17741490 SGTC_668 1682-0499 62.6 µM 2.30639809551084 0.038679716959817 no 206 0.0105441991571845 30 682214 SGTC_534 k292-0788 63.4 µM 2.28483777916254 0.0401122619085817 no 207 0.0111611707644228 51 4146317 SGTC_2064 5220758 200 µM 2.28175023058675 0.0403208940987185 no 208 0.0112520453247756 60 788518 SGTC_663 1486-0733 13.9 µM 2.27698347030633 0.040644723915659 no 209 0.0113936063624981 35 722445 YPR165W RHO1 SGTC_2040 5100729 123 µM 2.27481863394886 0.0407924874547295 no 210 0.0114584059693054 38 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_950 1165-0508 94.1 µM 2.27255436780365 0.0409475037472882 no 211 0.0115265240849491 33 6148369 SGTC_2878 9043973 25.97 µM 2.26383198849809 0.0415491268707209 no 212 0.0117922251322726 22 6465167 SGTC_1845 st056753 3.01 µM 2.24525923641772 0.0428540405668187 no 213 0.0123757476449592 46 5375839 SGTC_2082 5219693 150 µM 2.24007418637646 0.0432241954311425 no 214 0.0125430535265374 25 2834649 SGTC_20 0481-0013 4.944 µM 2.23318258037069 0.043720171508163 no 215 0.0127684532903829 57 182045 SGTC_427 1354-0053 47.3 µM 2.23114931324435 0.0438673760038086 no 216 0.0128356200815231 28 6813657 SGTC_29 0299-0004 12.984 µM 2.22933229127937 0.0439992628075461 no 217 0.0128959018163222 19 16871 A napthoquinone isolated from Swertia calycina. SGTC_2433 5607874 27.82 µM 2.2222140774426 0.0445190144926354 no 218 0.0131344207724554 30 2252428 SGTC_3031 9088762 49.47 µM 2.21837199664783 0.0448016010220201 no 219 0.0132647394310533 38 205253 SGTC_2146 5545642 200 µM 2.21809518599555 0.0448220162036637 no 220 0.0132741714960393 34 825326 SGTC_230 MPP+ 141.667 µM 2.21513650633513 0.0450406912653059 no 221 0.0133753481842396 41 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_816 0325-0417 81.3 µM 2.21142899643456 0.0453159233531942 no 222 0.0135030718635811 40 68101 SGTC_832 4083-0019 164 µM 2.21140121358043 0.0453179909471824 no 223 0.0135040329433724 81 1990758 SGTC_95 0471-0001 561.058 µM 2.20329796448083 0.0459242791990914 no 224 0.013786877178703 33 4015405 SGTC_78 0336-0123 156.75 µM 2.20327296023343 0.0459261600633761 no 225 0.013787757801198 34 6765896 SGTC_1518 st038567 90.8 µM 2.20159650248497 0.0460524074753971 no 226 0.0138469116057133 28 77966 SGTC_325 2810-4341 181 µM 2.1986590664503 0.0462742862335003 no 227 0.0139510868056298 32 774970 SGTC_2365 9042475 200 µM 2.18028436773419 0.0476817611282997 no 228 0.0146181945464776 36 6464479 SGTC_583 1488-1091 88.9 µM 2.17989567131935 0.0477119009327793 no 229 0.0146325979402599 57 4303273 SGTC_1298 1079-1278 263 µM 2.17220860214391 0.0483111022377166 no 230 0.0149199660714024 37 2840950 SGTC_789 1309-1135 70.6 µM 2.1648646480501 0.0488891658918874 no 231 0.0151990261018317 29 3092424 SGTC_1960 st011366 51.8 µM 2.16302538442414 0.0490348016564056 no 232 0.0152696136344043 40 3972846 SGTC_1210 3013-0140 750 nM 2.15565640256268 0.0496217680883113 no 233 0.015555252423146 33 905973 SGTC_1388 3346-4487 254 µM 2.1499018453841 0.0500840273812629 no 234 0.0157814898198701 33 3345614 SGTC_615 k087-0205 167 µM 2.14596763873389 0.0504020306065097 no 235 0.0159377803262824 30 9642773 SGTC_2880 9042983 58.44 µM 2.14581578295873 0.0504143373343153 no 236 0.0159438394614343 55 6464714 SGTC_464 bw-b 70c 158 µM 2.14365545093853 0.050589674870629 no 237 0.0160302520991911 48 5353454 SGTC_2181 6316240 54.2555 µM 2.14200418931458 0.0507240223416233 no 238 0.0160965724599938 33 12779990 SGTC_2497 7-hydroxyflavone 100 µM 2.14092192606737 0.0508122298485139 no 239 0.0161401673244079 42 5281894 SGTC_680 0417-1641 114 µM 2.13684793925936 0.05114536695244 no 240 0.0163051807635768 42 2835990 SGTC_3263 9137018 49.47 µM 2.13554723490212 0.0512520931166656 no 241 0.016358168095382 53 43844957 SGTC_250 brefeldin a 552.239 µM 2.13012645526462 0.0516987913470809 no 242 0.016580587372617 16 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2344 7990960 76.95 µM 2.1269940737008 0.0519583221449517 no 243 0.0167102878001598 89 140813 SGTC_1478 0453-0656 35.7 µM 2.12601119977926 0.0520399703567125 no 244 0.0167511634991435 50 5258496 SGTC_585 0kpi-0023 191 µM 2.12591264814748 0.0520481627479623 no 245 0.016755266772392 30 64601 SGTC_1442 4112-3290 3 µM 2.12557581791919 0.0520761704764096 no 246 0.0167692974507165 27 704353 SGTC_2732 terfenadine 20 µM 2.12337529579111 0.0522594405337208 no 247 0.0168612078261322 37 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_913 3487-1245 167 µM 2.11864199380481 0.0526553883150762 no 248 0.0170603669712763 56 4016153 SGTC_2264 7948757 110.76 µM 2.11642600074957 0.05284157578663 no 249 0.0171542963283065 27 2971411 SGTC_3281 9140613 49.47 µM 2.11622277251367 0.0528586771102706 no 250 0.0171629326492921 34 16013766 SGTC_1531 st059297 52.4 µM 2.11591533683183 0.0528845556639734 no 251 0.0171760043972785 39 7566702 SGTC_698 k064-0052 127 µM 2.11576938524347 0.0528968447300923 no 252 0.0171822130380938 31 5088751 SGTC_3041 9091929 49.47 µM 2.1057406630506 0.0537466979779021 no 253 0.0176134427985037 38 25236887 SGTC_88 0180-0332 8.668 µM 2.1018515120843 0.054079167754715 no 254 0.0177831425637844 46 3101745 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.10125447234479 0.0541303503921249 no 255 0.0178093169865733 41 75037 A free radical scavenger. SGTC_3147 9097027 49.47 µM 2.09889541472995 0.0543329612671568 no 256 0.0179130605767603 58 25236841 SGTC_578 3460-0051 92 µM 2.09588599176726 0.0545923000053296 no 257 0.0180461528273235 57 2876744 SGTC_3178 9107506 49.47 µM 2.09442491396586 0.0547185617054911 no 258 0.0181110726651729 67 8897194 SGTC_2842 9000675 19.48 µM 2.09015247500885 0.0550890971836039 no 259 0.0183020525624571 46 2989072 SGTC_2468 5987765 72.9 µM 2.08648209226284 0.0554089987023747 no 260 0.01846748783915 35 26772094 SGTC_1019 4262-0212 3.4 µM 2.08449401973417 0.0555828856175536 no 261 0.0185576268165208 56 4677213 SGTC_1956 st077085 54 µM 2.07831870597948 0.056125757952021 no 262 0.0188400073324151 55 24208685 SGTC_1361 1608-0041 5.61 µM 2.07636449690871 0.0562984208520991 no 263 0.0189301261281866 46 X1361 SGTC_821 1114-0266 29.2 µM 2.07076786711077 0.0567952249241583 no 264 0.0191902472280656 40 3123235 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.06891895869379 0.0569601062980975 no 265 0.0192768460971731 52 688803 SGTC_2905 7799065 20.05 µM 2.06353906804543 0.0574420169089327 no 266 0.0195307199671978 58 1296806 SGTC_2177 5811945 192 µM 2.05715197231117 0.0580183072669412 no 267 0.019835804865741 44 5343475 SGTC_2512 diallyl trisulfide 49.23 µM 2.05668169277238 0.0580609182683795 no 268 0.019858427147743 49 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_462 ag-879 158 µM 2.05063864428319 0.058610656697752 no 269 0.0201510750533372 65 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3054 9094397 49.47 µM 2.04050510410773 0.0595416705442728 no 270 0.0206500215934229 56 2598354 SGTC_692 k241-0027 77.8 µM 2.03760502255016 0.0598102363278715 no 271 0.0207947246759969 44 3600480 SGTC_1857 st056007 79.3 µM 2.02941616606007 0.0605737002179879 no 272 0.021207959950385 28 619834 SGTC_2832 7992762 51.95 µM 2.01912075540592 0.0615443559403575 no 273 0.0217373350503486 58 2985177 SGTC_870 0573-2213 57.6 µM 2.01546891801765 0.0618915565332613 no 274 0.0219277698081627 38 3916321 SGTC_1385 3091-4834 14.1 µM 2.01482736310912 0.0619527103148572 no 275 0.0219613704537079 44 4072814 SGTC_1178 0988-0033 191 µM 2.0064179906424 0.0627586686450054 no 276 0.0224058352219462 49 5392207 SGTC_2104 5389443 200 µM 2.00635857044086 0.0627643924380606 no 277 0.02240900258299 58 2244536 SGTC_1991 st073000 8.92 µM 2.00347638372366 0.0630425146898675 no 278 0.0225630899914593 79 4301969 YIL048W NEO1 SGTC_2231 micatex 6.853 µM 2.00244974675287 0.0631418135671049 no 279 0.0226181913703478 47 20737 An antifungal of unknown mechanism. SGTC_2933 9026794 32.47 µM 1.99948161184325 0.0634295841257414 no 280 0.0227781347383436 45 17586027 SGTC_886 0866-0150 153 µM 1.99550740459724 0.0638164939893937 no 281 0.0229937836877953 50 271463 SGTC_469 w7 172 µM 1.98537241419218 0.0648114985851808 no 282 0.0235515263844252 36 45115570 A P450 inhibitor. SGTC_2773 thioridazine 9.09 µM 1.98494271237552 0.0648539493276296 no 283 0.0235754227823328 43 5452 An antipsychotic. SGTC_2147 5545932 89.7195 µM 1.98477490872794 0.0648705327051182 no 284 0.0235847601441603 60 797404 SGTC_1139 k015-0024 46.9 µM 1.98438272420947 0.0649093036039809 no 285 0.0236065952140047 41 2766652 SGTC_176 1486-1328 72.834 µM 1.97693464226313 0.0656490319131991 no 286 0.0240245091993505 70 22310231 SGTC_2401 5128683 200 µM 1.97458907941288 0.0658833367255864 no 287 0.0241573996807065 55 708373 SGTC_2876 9059903 25.97 µM 1.97404770253455 0.0659375083144362 no 288 0.0241881595414307 53 6916095 SGTC_581 0958-0271 211 µM 1.9710502418266 0.0662380669090002 no 289 0.0243590646708424 41 4591145 SGTC_2713 st079149 53.4 µM 1.97091182476738 0.0662519717240171 no 290 0.0243669811744774 51 3103253 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.95660539326007 0.0677013665474687 no 291 0.0251969402219762 74 279621 SGTC_2868 9035608 32.47 µM 1.94554457650867 0.0688386410372248 no 292 0.0258547350658739 46 6462614 SGTC_1339 1486-1321 22.7 µM 1.94498677523559 0.0688963819960019 no 293 0.0258882850028713 64 3469382 SGTC_1546 5-methoxyflavanone 78.7 µM 1.94497513308864 0.0688975875338206 no 294 0.0258889856281283 37 147795 SGTC_1336 1486-0901 104 µM 1.9405092434188 0.0693612285532968 no 295 0.0261589159597914 39 5006114 SGTC_2767 sibutramine 71.45 µM 1.93816963270076 0.0696050803258522 no 296 0.0263012651611371 37 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3007 9078383 71.4286 µM 1.9376666242603 0.0696575937457074 no 297 0.0263319541864706 62 6496995 SGTC_1701 st028638 40.4 µM 1.9372355533713 0.0697026212448079 no 298 0.0263582780445574 37 3490878 SGTC_1028 k015-0029 4.8 µM 1.93717133923449 0.0697093306479003 no 299 0.0263622012391035 70 4588309 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.93147046635326 0.0703069689402371 no 300 0.0267124491011159 88 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_209 4077-0173 175.592 µM 1.92891294541251 0.0705763578648241 no 301 0.0268708352267223 27 15993494 SGTC_952 1185-0122 232 µM 1.92770709721565 0.0707036472240156 no 302 0.0269457844123131 59 678600 SGTC_2782 7736369 71.43 µM 1.92718739760774 0.070758561095085 no 303 0.0269781399769327 61 2950836 YOL077C BRX1 SGTC_2560 caryophyllene 100 µM 1.92236204312147 0.0712699962744396 no 304 0.0272801090812375 56 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3038 9091290 49.47 µM 1.92005525465998 0.0715154912063979 no 305 0.0274254601946134 43 25236843 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.9169917829798 0.0718425169423025 no 306 0.0276194877829314 57 115019 SGTC_2465 5809242 33.21 µM 1.91495367262212 0.0720607198185314 no 307 0.0277492060009944 48 2731748 SGTC_3117 9124945 49.47 µM 1.90535831926732 0.0730948436590652 no 308 0.0283667546802405 38 17592065 SGTC_1246 0422-0085 105 µM 1.90526104537452 0.0731053850401648 no 309 0.0283730732293573 74 264295 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.90323774013042 0.0733249105062432 no 310 0.0285047653465234 38 364106 SGTC_2331 7980721 200 µM 1.89949250702618 0.0737325925465785 no 311 0.0287498754390325 74 2981221 SGTC_2113 5491891 107.031 µM 1.89445100152561 0.0742841115502978 no 312 0.0290825861336112 71 789979 SGTC_895 0964-0006 13.7 µM 1.88520848910689 0.0753033767179417 no 313 0.0297008475802004 89 6738897 SGTC_1609 st001574 46.4 µM 1.88407915355203 0.0754286473656702 no 314 0.0297771347805519 55 3960012 SGTC_1439 4092-1168 46 µM 1.88377151838755 0.0754627990609989 no 315 0.0297979438451766 52 2886240 SGTC_2903 5923464 63.88 µM 1.87383704327807 0.0765720069066494 no 316 0.0304764444892831 50 2876576 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.87320773816056 0.076642685785187 no 317 0.0305198520942989 41 140250 A respiratory chain inhibitor. SGTC_35 0133-0054 64.071 µM 1.86869855037064 0.0771505764791109 no 318 0.030832382910612 77 99677 SGTC_1488 4013-0813 75.9 µM 1.86797499351674 0.0772323115977764 no 319 0.0308827782903573 45 2910057 SGTC_1124 fisetin 1.16336 µM 1.86205183332226 0.0779038846507524 no 320 0.0312978922049504 60 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2911 7942208 15.64 µM 1.85997557996707 0.0781403380545499 no 321 0.031444490502723 42 1243384 SGTC_2647 atorvastatin 60.16 µM 1.85932561479657 0.0782144708896419 no 322 0.0314904991846168 37 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_962 1254-0300 21.5 µM 1.85763781884259 0.0784072242981003 no 323 0.0316102320811561 44 7340576 SGTC_3238 9133470 49.47 µM 1.85685819704488 0.0784963819044845 no 324 0.0316656656515866 50 3534688 SGTC_1106 tegaserod maleate 11.7 µM 1.85202494792891 0.0790508285755824 no 325 0.0320111202696707 64 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2925 9010536 32.5 µM 1.84737993153608 0.0795864721631921 no 326 0.0323460478285358 47 2994177 SGTC_743 1275-0778 158 µM 1.84032120611418 0.080405705595361 no 327 0.0328605469089111 80 2849257 YMR203W TOM40 SGTC_123 0083-0120 66.675 µM 1.83852238727381 0.0806154911682647 no 328 0.0329927330440187 75 16001701 SGTC_1201 1889-3372 45.9 µM 1.83638194481063 0.0808656565959617 no 329 0.0331505939864491 65 5392199 SGTC_2358 9037157 4 µM 1.83348845554054 0.0812047658594518 no 330 0.0333649819121268 76 2388925 SGTC_174 3553-0389 74.3 µM 1.83078919209752 0.0815220786835595 no 331 0.0335660070699011 66 738071 SGTC_2171 5739187 198.077 µM 1.83022219613522 0.0815888507577432 no 332 0.0336083600222919 55 2262761 SGTC_910 3454-3003 490 µM 1.82653997999275 0.0820234894605049 no 333 0.0338844823962583 78 820824 SGTC_629 3448-6466 76.7 µM 1.82405205285703 0.08231814361109 no 334 0.034072101612162 62 573744 SGTC_1706 st031321 9.9705 µM 1.81827141892502 0.0830058415042734 no 335 0.0345113294585095 55 6103185 SGTC_1119 parthenolide 318.541 nM 1.81761770984868 0.0830838817096571 no 336 0.0345612914578522 68 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1524 corynanthine 62.1 µM 1.81327524284712 0.0836036894683733 no 337 0.034894689872618 66 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_854 0422-0053 192 µM 1.80862508532438 0.0841630341647833 no 338 0.0352546342981888 70 3596728 SGTC_1481 3346-2004 36 µM 1.80697378706227 0.0843623351652046 no 339 0.0353831832020556 63 2770522 SGTC_3079 9117512 49.47 µM 1.80479528099629 0.0846258082563174 no 340 0.0355533615629626 50 7185044 SGTC_2128 5255449 168.493 µM 1.79970402688223 0.0852439611209136 no 341 0.0359536924626275 70 736008 SGTC_1872 amphotericin b 148 nM 1.79565550863001 0.085737920423478 no 342 0.0362746609495338 69 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2161 5662504 8.5105 µM 1.78834806623211 0.0866349199219385 no 343 0.0368599347647995 73 2859334 SGTC_485 niflumic acid 177 µM 1.78808352319555 0.0866675240395621 no 344 0.036881266749086 57 4488 A COX2 inhibitor. SGTC_3164 9100705 49.47 µM 1.78259071766985 0.0873465690444922 no 345 0.0373264759688932 45 17174235 SGTC_770 0389-1121 67.2 µM 1.78230269010511 0.0873822855741033 no 346 0.0373499421324445 66 6753108 SGTC_3276 9139060 49.47 µM 1.77689647563155 0.0880547011843433 no 347 0.0377926371864554 81 4870619 SGTC_2526 patulin 37.61 µM 1.77548736310873 0.0882305963445363 no 348 0.0379087251426239 86 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1802 st050112 57.9 µM 1.77510467639266 0.0882784111341723 no 349 0.0379403024954779 54 4662563 SGTC_2333 9017922 200 µM 1.77358960553608 0.0884679012419655 no 350 0.0380655291423937 60 3163164 SGTC_2012 4023501 200 µM 1.77288513853234 0.0885561121641566 no 351 0.0381238708723007 89 3477460 SGTC_3350 9150499 3.57 µM 1.7699079012635 0.088929635183045 no 352 0.0383712421853487 85 4910996 YPR165W RHO1 SGTC_1456 k015-0012 13 µM 1.76892421588716 0.0890533053868149 no 353 0.0384532611966039 81 2989616 SGTC_2990 9074105 71.4286 µM 1.76734914852388 0.0892515914042622 no 354 0.0385848867722451 61 6502001 SGTC_2127 5253358 187.912 µM 1.7672444732751 0.0892647806552808 no 355 0.0385936472912245 66 20612 SGTC_1064 honokiol 6.76 µM 1.7668246700767 0.089317691109129 no 356 0.0386287978993811 76 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1189 1431-2119 7.28 µM 1.76604316700524 0.0894162510269076 no 357 0.0386943035368088 87 3107275 SGTC_2202 7226349 200 µM 1.75984686601686 0.0902005678334106 no 358 0.0392168871789183 46 844334 SGTC_89 0302-0250 142.109 µM 1.75964995288845 0.0902255762636178 no 359 0.0392335881505093 78 4203518 YLR208W SEC13 SGTC_3080 9117754 49.47 µM 1.75731325256719 0.0905227359762911 no 360 0.0394322150649564 71 9550191 SGTC_3033 9090887 49.47 µM 1.75674148101941 0.0905955590619412 no 361 0.0394809418281326 89 19325384 SGTC_1347 1493-0251 600 nM 1.75610300337208 0.0906769294835131 no 362 0.0395354112034273 65 3986378 SGTC_926 2268-1401 59.4 µM 1.75133699537114 0.0912860450501316 no 363 0.0399439393644257 71 2931578 SGTC_1986 st071812 45 µM 1.74990402952817 0.0914697758635523 no 364 0.0400674376341513 53 11838594 SGTC_1153 4055-0057 267 µM 1.7492158854589 0.0915581050954613 no 365 0.0401268545939465 86 882706 SGTC_2233 sulbentine 40.3845 µM 1.74912225149965 0.0915701287063505 no 366 0.0401349448338314 104 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2216 7189485 200 µM 1.74782212459456 0.0917371999694741 no 367 0.0402474164932336 55 731273 SGTC_3043 9092303 49.47 µM 1.74740461431612 0.0917908995060865 no 368 0.0402835888210002 63 25236084 SGTC_2399 5884133 200 µM 1.74709072610139 0.0918312866614179 no 369 0.0403108009061928 86 722445 SGTC_3102 9121669 49.47 µM 1.74696646982352 0.0918472780197103 no 370 0.0403215772484195 63 41905072 SGTC_1805 st050013 60.3 µM 1.74625248236131 0.0919392057446615 no 371 0.0403835444093077 61 4037144 SGTC_2808 7946468 45.46 µM 1.74075001205193 0.0926499500505256 no 372 0.040863703821803 82 2970879 SGTC_814 3342-0569 96 µM 1.73973077875596 0.0927820475249412 no 373 0.0409531510829535 69 4346283 SGTC_510 ag-490 170 µM 1.73718942901369 0.0931120250003942 no 374 0.0411768700959254 39 5328779 SGTC_650 1328-0195 38 µM 1.73707150175111 0.093127358106739 no 375 0.0411872754278171 70 2780821 SGTC_2112 5488546 200 µM 1.73652555098215 0.0931983678858953 no 376 0.0412354752694869 75 600757 SGTC_3051 9093778 49.47 µM 1.73581942217341 0.0932902707552826 no 377 0.0412978844087098 68 17217378 SGTC_3140 9094243 49.47 µM 1.73427015654433 0.0934921427048648 no 378 0.0414350800255098 71 19291112 SGTC_1916 st067606 49.2 µM 1.73365383730673 0.0935725397912544 no 379 0.041489760925302 91 19590279 SGTC_387 norethindrone acetate 66.7 µM 1.73338623104055 0.0936074641576505 no 380 0.0415135216112164 68 541197 SGTC_310 1273-0058 1.06 µM 1.73124840127599 0.0938868105601509 no 381 0.0417037350246913 51 2734232 SGTC_559 1550-0661 158 µM 1.72838791532113 0.0942615469119875 no 382 0.0419593503092099 63 5830875 SGTC_1366 1683-0113 21.9 µM 1.72556643671141 0.0946322527390863 no 383 0.0422127209493133 61 708623 SGTC_1772 st048439 82.2 µM 1.71922690270152 0.0954691033817324 no 384 0.0427865319992799 76 2927068 YDL195W SEC31 SGTC_3066 9117245 49.47 µM 1.71919777029878 0.0954729615390811 no 385 0.042789183344095 51 17176980 SGTC_737 1950-0117 57.9 µM 1.71814820820257 0.0956120371238655 no 386 0.0428847927725714 81 5393513 SGTC_2496 diffractaic acid 79.83 µM 1.71696092441201 0.0957695415999015 no 387 0.0429931559332852 76 94870 An apoptosis inducer which activates caspases. SGTC_2126 5251174 33.877 µM 1.70854429681303 0.096891562943102 no 388 0.0437676971886889 78 790722 SGTC_672 1441-0018 53.7 µM 1.70370342917011 0.0975412556591213 no 389 0.0442182535886527 61 251141 SGTC_2821 7996764 71.43 µM 1.69386528764426 0.0988714659321919 no 390 0.0451454422165073 69 2987135 SGTC_433 pimozide 108 µM 1.69047957837068 0.0993323021104143 no 391 0.045468120978365 59 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3200 9114385 49.47 µM 1.68992039459147 0.0994085646689776 no 392 0.0455215926321237 74 17018030 YLR208W SEC13 SGTC_1794 st048918 76.9 µM 1.68976082811515 0.0994303344988623 no 393 0.0455368603619254 56 672303 SGTC_313 3474-0040 5.03 µM 1.68450952256169 0.100148721556942 no 394 0.046041620347364 96 1043375 YIL048W NEO1 SGTC_3192 9110362 49.47 µM 1.68281630847895 0.100381161889476 no 395 0.0462053284705045 67 16649480 SGTC_2217 6934799 96.0675 µM 1.68156460372401 0.100553245805298 no 396 0.0463266495918996 59 675606 SGTC_264 promethazine 12.5 mM 1.68041936861555 0.100710880756566 no 397 0.0464378751025245 107 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1902 st060212 70.5 µM 1.67620940440868 0.101291906849216 no 398 0.0468485913756836 78 688944 SGTC_16 erodoxin 22.806 µM 1.67120635817083 0.101985558977947 no 399 0.047340462413048 115 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_126 0417-1624 672.48 µM 1.67029702332813 0.102112004931268 no 400 0.0474303059170722 109 41912 YDL195W SEC31 SGTC_1671 st016596 74.5 µM 1.66937076612534 0.102240921216652 no 401 0.0475219617728982 76 2829167 SGTC_741 4582-0002 126 µM 1.66778837239287 0.102461432256187 no 402 0.0476788724587508 75 2912688 SGTC_1539 benzyladenosine 56 µM 1.66430856975191 0.102947568522205 no 403 0.0480253903555573 77 92208 A nucleotide analog. SGTC_366 0181-0206 4.31 µM 1.66337890515302 0.103077727932793 no 404 0.0481183065000133 89 274874 SGTC_1880 MG-132 525 µM 1.661582256662 0.103329609643716 no 405 0.0482982817105112 96 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1258 0671-0043 57.1 µM 1.66097076577255 0.10341543964549 no 406 0.0483596591128409 81 4298767 SGTC_1128 3448-9350 235 µM 1.66086687857508 0.103430026587685 no 407 0.0483700928182605 65 619386 SGTC_1452 4194-0072 190 µM 1.65705609306737 0.103966136747445 no 408 0.0487540674695545 88 1343545 SGTC_2062 5245942 200 µM 1.65597322626613 0.104118843989612 no 409 0.0488636204631599 63 1376160 SGTC_2094 5332512 191.667 µM 1.65226514064569 0.104642994615458 no 410 0.0492402561385947 70 755774 SGTC_2804 7954240 19.48 µM 1.65195530484396 0.104686877334128 no 411 0.0492718312711069 98 828705 SGTC_2449 5812982 45.77 µM 1.65176371685108 0.104714019026391 no 412 0.0492913639468752 53 776185 SGTC_1016 4226-1401 38 µM 1.65005664461284 0.104956079822368 no 413 0.0494656755472901 93 2901613 SGTC_2967 9089538 49.85 µM 1.64894833154809 0.105113454002866 no 414 0.0495791101748771 98 728216 SGTC_1564 D-Arginine 115 µM 1.64637364489297 0.105479703948131 no 415 0.049843427849508 105 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_982 1491-0518 27.5 µM 1.64610481835015 0.105517997753734 no 416 0.0498710903028167 67 3091256 SGTC_1260 0700-1617 7.75 µM 1.64533959780402 0.10562705693717 no 417 0.0499498991136538 85 2853078 SGTC_1046 2001-0062 216 µM 1.64408663668922 0.105805804818149 no 418 0.0500791539433839 97 739778 SGTC_3160 9100216 49.47 µM 1.64340251687088 0.10590349383019 no 419 0.0501498398673927 61 17191039 SGTC_303 1348-1668 34.2 µM 1.63769357797858 0.106721245282993 no 420 0.0507428154771588 75 5380509 SGTC_3076 9116187 49.47 µM 1.63572877559576 0.107003735961991 no 421 0.050948182133574 63 27241210 SGTC_1511 0906-3109 28.5 µM 1.63387052995971 0.107271402289272 no 422 0.0511430194372659 82 2882180 SGTC_48 0382-0018 55 µM 1.62808211390804 0.108108273255148 no 423 0.0517537377767033 54 762596 SGTC_364 0083-0097 67.7 µM 1.6254571586628 0.108489326118223 no 424 0.0520325926112544 81 5207356 SGTC_1645 Cervolide 78 µM 1.62450976537441 0.108627091939467 no 425 0.0521335289701666 86 23173 A fragrance. SGTC_1675 st018485 24.5 µM 1.62238207287677 0.108936950268399 no 426 0.0523607826182673 94 3323024 SGTC_1146 3579-1023 7 µM 1.62166948251434 0.109040867527061 no 427 0.0524370682355337 93 X1146 SGTC_1294 1000-1494 117 µM 1.61788712695512 0.109593642344089 no 428 0.0528434625128496 81 712797 YDL207W GLE1 SGTC_1391 3442-0225 151 µM 1.61769257423237 0.109622129689667 no 429 0.0528644335575702 68 5227075 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.61720691094001 0.109693266045804 no 430 0.0529168125298022 88 15053 SGTC_1415 3966-0071 78.1 µM 1.61684575645134 0.109746186756721 no 431 0.0529557898602624 79 2893185 SGTC_34 0469-0683 81.75 µM 1.6135968954864 0.110223073174629 no 432 0.053307445341573 78 3690923 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.6135966527852 0.110223108855133 no 433 0.0533074716804284 82 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.61187883531085 0.110475859855331 no 434 0.0534941543090527 87 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_889 0919-1524 82.7 µM 1.61163790186689 0.110511342785894 no 435 0.0535203789557055 69 3905452 SGTC_81 0411-0046 9.971 µM 1.61125838066146 0.110567252486092 no 436 0.053561708987299 135 12925265 SGTC_679 0422-0091 41.4 µM 1.60615529345975 0.111320990808308 no 437 0.0541198967037628 98 627384 YHR062C RPP1 SGTC_974 1326-0144 138 µM 1.60614886206108 0.111321943056436 no 438 0.0541206030789578 88 5411856 SGTC_2652 actinonin 100 µM 1.60401048705932 0.111638879270009 no 439 0.0543558705074895 83 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_499 genistein 192 µM 1.60149793254487 0.112012098213198 no 440 0.0546333387819449 57 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1279 0874-0590 65.2 µM 1.59972341065579 0.112276225532988 no 441 0.0548299780095942 72 3523074 SGTC_1440 4100-1550 40 µM 1.59940440287862 0.112323755155454 no 442 0.0548653873135709 84 742806 SGTC_2673 kobusone 100 µM 1.59841161707949 0.112471764338171 no 443 0.0549757004535325 65 6710676 An epoxy ketone and protein crosslinker. SGTC_169 k015-0017 16.025 µM 1.59837229950801 0.11247762885371 no 444 0.0549800728207998 85 1840002 SGTC_2854 9024559 71.43 µM 1.59555244834021 0.112898800955284 no 445 0.0552943756526316 77 3163529 SGTC_9 0092-0002 10.449 µM 1.59335094875717 0.11322839791517 no 446 0.0555407415219131 89 759368 SGTC_1702 st027038 51 µM 1.58810778454664 0.114016139816817 no 447 0.0561309841656253 78 5521182 SGTC_316 k060-0003 58.6 µM 1.58592220975047 0.114345654605318 no 448 0.0563784784791281 82 6152314 SGTC_626 0214-0009 33 µM 1.58218876486337 0.114910106066941 no 449 0.0568032422149057 91 3437874 SGTC_1183 1254-0324 198 µM 1.58067462640509 0.115139589344288 no 450 0.0569762264368973 69 5799357 SGTC_1308 1187-1617 41.4 µM 1.57820294827195 0.115514897383887 no 451 0.0572594965797841 101 2882570 SGTC_3196 9111891 49.47 µM 1.57541580476295 0.115939148523345 no 452 0.0575802493247393 91 18891510 SGTC_1297 1068-0111 14.1 µM 1.57460723225938 0.116062433916671 no 453 0.0576735662237572 92 767057 SGTC_2234 tolnaftate 200 µM 1.57229409166351 0.116415638978384 no 454 0.057941181322226 56 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3187 9109394 49.47 µM 1.57197046764036 0.116465115494529 no 455 0.0579787001897521 103 17098090 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.56598992889955 0.117382122143259 no 456 0.0586754874535078 97 390807 SGTC_1682 st012968 530 nM 1.56462626614993 0.117591928893702 no 457 0.0588352832000966 72 24207270 SGTC_1166 k206-0078 225 µM 1.56193178314025 0.118007269576203 no 458 0.0591520300521624 97 5404595 SGTC_1155 4088-0394 48.2 µM 1.56008659908078 0.11829229316949 no 459 0.0593697089727996 92 2326248 SGTC_2455 5377712 9.75 µM 1.55966495586796 0.118357492202953 no 460 0.0594195388499049 80 2243908 SGTC_1833 st055984 71 µM 1.55536324763581 0.119024120793083 no 461 0.0599297909735604 72 676288 SGTC_2653 dihydrofissinolide 100 µM 1.55079158289294 0.119735485257483 no 462 0.0604758191946868 73 6857746 SGTC_1591 genipin 88.4 µM 1.54959483755425 0.11992219647946 no 463 0.0606193964118687 99 442424 A DNA cross-linking agent. SGTC_334 1502-1024 68.5 µM 1.54632328255198 0.120433658023985 no 464 0.0610132558739173 74 3296216 SGTC_2862 9027634 71.43 µM 1.54539228123604 0.120579487366634 no 465 0.0611257031063763 97 5012562 SGTC_2966 9084041 48.03 µM 1.52922365475328 0.123131941302693 no 466 0.0631045041941671 78 17741380 SGTC_1899 st063254 59.6 µM 1.52827083627356 0.123283530408746 no 467 0.0632226538227557 95 3093813 SGTC_2028 5153890 36.43 µM 1.52216199530623 0.124258526203195 no 468 0.0639842475988827 111 2830968 YPR165W RHO1 SGTC_2238 6671620 73.2395 µM 1.52141373583875 0.124378321196774 no 469 0.064078022021896 78 729941 SGTC_225 nsc-122657 1.016 µM 1.52080684139464 0.124475543205104 no 470 0.0641541585468845 79 275685 SGTC_2872 9044037 25.97 µM 1.52061430905365 0.124506397197986 no 471 0.0641783269297739 76 6465195 SGTC_966 1300-0360 30.2 µM 1.519454047025 0.124692446520431 no 472 0.06432412327241 126 70588 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.51930510673188 0.124716343329008 no 473 0.0643428574554834 92 229346 A bile salt which induces apoptosis. SGTC_31 0508-1974 57.237 µM 1.50376087127851 0.127227963754445 no 474 0.0663214747642078 78 6810525 SGTC_1227 3909-8010 46.6 µM 1.5032208026038 0.12731585551421 no 475 0.0663910574271457 79 15982272 SGTC_2426 5582046 32.21 µM 1.50022895219294 0.127803519719769 no 476 0.0667775530228792 93 2251934 SGTC_2963 9082507 9 µM 1.49864589873725 0.128062078016599 no 477 0.0669827593873198 112 16459611 SGTC_1240 0356-0016 42.1 µM 1.49853409077654 0.128080353210243 no 478 0.0669972711312004 83 4305613 SGTC_1272 0839-0021 27 µM 1.49733366370948 0.128276679113743 no 479 0.0671532298349819 105 5027250 SGTC_634 1611-4317 11.2 µM 1.49634579331846 0.128438398733258 no 480 0.0672817837562107 109 2843522 SGTC_3120 9124077 49.47 µM 1.49614619369904 0.12847109142841 no 481 0.0673077812174725 83 18774327 YGL155W CDC43 SGTC_1056 3448-1962 115 µM 1.49607519880588 0.128482721171776 no 482 0.0673170300359056 105 715507 SGTC_1588 farnesol 29.9 µM 1.49603698148089 0.128488981891973 no 483 0.0673220091824562 94 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1438 4092-1045 4 µM 1.49455294582176 0.128732258758185 no 484 0.067515577114055 113 1351342 SGTC_3050 9093513 49.47 µM 1.49387084223889 0.128844182624129 no 485 0.0676046903990919 122 25236664 SGTC_49 0717-0965 32.132 µM 1.49146452399948 0.129239565535117 no 486 0.0679197892852392 98 5889349 YGL099W LSG1 SGTC_1425 4048-4433 7.33 µM 1.49095570823092 0.129323276818366 no 487 0.0679865619427464 112 23734946 SGTC_330 1488-0319 80.1 µM 1.48796538094568 0.129816010193911 no 488 0.0683800118204649 113 6846614 SGTC_678 1218-2179 85.9 µM 1.48580215754355 0.130173266262422 no 489 0.0686657296561597 87 6820081 YOR116C RPO31 SGTC_1111 tnp00062 510.699 nM 1.48377583778203 0.130508529297621 no 490 0.068934199606376 89 676306 SGTC_2762 leflunomide 42.06 µM 1.48162761552041 0.130864613200306 no 491 0.0692197034284072 121 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_638 3970-0837 4.09 µM 1.47907223471949 0.131289060351877 no 492 0.0695605049887961 81 4118451 YLR208W SEC13 SGTC_350 k064-0020 19.8 µM 1.47837221310456 0.131405499203383 no 493 0.0696540893226684 100 2790705 SGTC_2834 9001755 58.44 µM 1.47307222000904 0.132289392683013 no 494 0.0703657815918941 101 2989575 SGTC_1341 1486-1360 280 µM 1.47258052730004 0.132371600786646 no 495 0.0704320893338042 97 3976547 SGTC_1993 st073995 70.8 µM 1.47032376648001 0.132749369413669 no 496 0.0707370435951144 110 3098394 SGTC_1770 st043884 66.3 µM 1.46881366074752 0.133002566590545 no 497 0.0709416688791649 129 670149 SGTC_2895 9054447 58.44 µM 1.46430383098765 0.133760701101255 no 498 0.0715554754510488 95 2697450 SGTC_1038 k292-0204 154 µM 1.46311974463696 0.133960245877037 no 499 0.071717308004297 98 4454212 SGTC_1626 st003712 1.76 µM 1.45739989249517 0.134927047762354 no 500 0.0725030133754235 118 24207035 SGTC_2023 5144124 124 µM 1.45727648907244 0.134947958719738 no 501 0.072520037016241 99 2830192 SGTC_1238 0333-0287 48.8 µM 1.45608506483056 0.13514996228163 no 502 0.0726845528472251 92 7226 SGTC_1168 k815-0004 80.5 µM 1.45461715772949 0.135399127907497 no 503 0.0728876391576414 127 642433 SGTC_1688 st021091 57.6 µM 1.45361956150322 0.135568641556313 no 504 0.0730259052484253 104 3656366 SGTC_1078 idebenone 36.1 µM 1.44971049076673 0.136234279908239 no 505 0.073569634519337 133 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2447 5741742 33.78 µM 1.44618253549621 0.13683693876737 no 506 0.0740630054182537 115 1776504 SGTC_606 k015-0008 38.6 µM 1.44535401106206 0.136978734317541 no 507 0.0741792370326749 103 1970475 SGTC_1 0258-0098 57.368 µM 1.44469345133478 0.137091855920672 no 508 0.074272005078058 117 6790032 YDR047W HEM12 SGTC_994 3910-0338 138 µM 1.44465211212335 0.137098937429082 no 509 0.0742778136411426 114 3479481 SGTC_675 1309-0189 238 µM 1.44385610599732 0.137235343970188 no 510 0.0743897279424522 95 4246530 SGTC_2352 9027995 87.8 µM 1.44378874670766 0.137246891158697 no 511 0.0743992042116293 92 2997347 SGTC_244 nsc-207895 1.295 µM 1.44231463359903 0.13749975985231 no 512 0.0746068169023825 50 42640 SGTC_1917 st066507 28.5 µM 1.44189269065573 0.137572198266114 no 513 0.0746663242674825 120 3156428 SGTC_754 3474-0146 171 µM 1.43867561542846 0.138125356448572 no 514 0.0751212256349356 102 24762078 SGTC_501 nsc-95397 161 µM 1.43805782802652 0.138231754902395 no 515 0.0752088234853665 112 262093 SGTC_1194 1488-0194 225 µM 1.43607278295445 0.138574007494687 no 516 0.0754908159063825 94 1391452 SGTC_1826 st055655 41.6 µM 1.43439208623792 0.138864236702649 no 517 0.0757302023630481 107 676168 SGTC_1459 k035-0031 35.7 µM 1.43075761472972 0.139493265843657 no 518 0.076249847258256 86 3877128 YMR208W ERG12 SGTC_1900 st060200 72.8 µM 1.42593506659332 0.140330906752688 no 519 0.0769435430796207 115 688945 SGTC_2096 5468907 200 µM 1.42408931615135 0.140652401952657 no 520 0.0772103093698809 99 759785 SGTC_2656 pseudo-anisatin 100 µM 1.42003563689135 0.141360230393424 no 521 0.0777986532047128 87 6708809 A neurotoxin. SGTC_2018 5133068 143 µM 1.42002508631705 0.141362075814118 no 522 0.0778001889236692 102 785362 SGTC_2015 5119600 184 µM 1.41623552365928 0.142025971685927 no 523 0.0783532791734456 124 2828786 SGTC_1147 3809-1045 12.3 µM 1.41423826982911 0.142376719847042 no 524 0.0786459774564487 118 325925 SGTC_2712 st079126 47.7 µM 1.41242287532498 0.142696038715716 no 525 0.0789127424323806 90 3152970 SGTC_1485 3909-9022 254 µM 1.40840949861888 0.143403689028907 no 526 0.079504924099414 98 714516 SGTC_760 0568-0725 82.9 µM 1.40792584520527 0.143489127915375 no 527 0.0795765145678623 108 3916171 SGTC_2260 7964312 200 µM 1.40626195423995 0.143783321878883 no 528 0.0798231765860347 104 231951 SGTC_2274 7947094 46.08 µM 1.40351892641052 0.144269206861087 no 529 0.0802310760914909 108 2971028 SGTC_1840 st055363 71 µM 1.40285954560445 0.144386170795808 no 530 0.0803293631819319 96 676033 SGTC_1424 4048-1941 275 µM 1.40276300951827 0.144403300162744 no 531 0.0803437604520783 105 X1424 SGTC_1175 0741-0056 27.6 µM 1.39958190961568 0.144968520808447 no 532 0.0808192771697805 110 765927 SGTC_47 0149-0135 24.25 µM 1.39932137889664 0.145014878031363 no 533 0.0808583157266255 117 5239155 SGTC_796 1234-0020 70.7 µM 1.39721610555403 0.145389843419372 no 534 0.0811742974887436 101 46495034 SGTC_2253 7938677 135.83 µM 1.39698210952935 0.145431560148762 no 535 0.0812094755503146 94 2301972 SGTC_643 k048-0106 28.4 µM 1.39610563836038 0.145587888672315 no 536 0.0813413430873916 125 6763920 SGTC_798 1287-0182 476 µM 1.39120089129861 0.146464790517817 no 537 0.0820822585277741 105 1649755 SGTC_1225 1216-0074 20.6 µM 1.38692589436401 0.147231987821328 no 538 0.0827321804813479 100 4241466 SGTC_1292 0kpi-0043 232 µM 1.38586086708671 0.147423537585131 no 539 0.0828946960651715 110 3333905 SGTC_869 0564-0080 44.1 µM 1.38561130058236 0.147468447339256 no 540 0.0829328128469703 89 6843321 SGTC_1443 4112-3303 14 µM 1.38510667628653 0.147559283013194 no 541 0.0830099253857072 131 704433 SGTC_3165 9101544 49.47 µM 1.38284151143144 0.147967489171438 no 542 0.083356733740332 108 5002184 SGTC_108 0509-0257 621.132 µM 1.38163655175968 0.148184943089097 no 543 0.0835416624743991 134 536624 SGTC_2598 perillyl alcohol 100 µM 1.38133176696321 0.148239980163128 no 544 0.0835884875176148 98 10819 An apoptosis inducer. SGTC_413 propylparaben 100 µM 1.38001710704019 0.148477533991514 no 545 0.0837906888465718 115 7175 A pharmaceutical preservative. SGTC_2686 alizarin 95.37 µM 1.37865384703211 0.148724138378505 no 546 0.0840007529067567 99 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2187 6125751 200 µM 1.37863108588008 0.148728258037065 no 547 0.0840042635144905 115 874498 SGTC_2728 chlorpromazine 9.18 µM 1.3766902734867 0.149079816250663 no 548 0.0843040135934812 95 2726 A thorazine and dopamine antagonist. SGTC_1653 st012112 65 µM 1.3744738117062 0.149481983908785 no 549 0.0846473175008997 87 720429 SGTC_1409 3909-8004 61.9 µM 1.37012721859523 0.150272755513537 no 550 0.0853235963126737 113 2119279 SGTC_696 1560-0013 611 µM 1.36300029633177 0.151575372519506 no 551 0.0864412086100294 126 1650269 SGTC_3158 9100007 49.47 µM 1.36244252072874 0.151677635238607 no 552 0.0865291361789971 93 19297233 SGTC_271 rotenone 740 µM 1.36200382631962 0.151758097789861 no 553 0.0865983387870345 106 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_772 k072-0172 35.3 µM 1.36158872136062 0.15183425982684 no 554 0.0866638583211339 98 5861980 SGTC_3123 9126162 49.47 µM 1.35946221950794 0.152224821344688 no 555 0.0870000832728896 103 25239884 SGTC_59 0330-0160 1.33 µM 1.35769040307009 0.152550748940878 no 556 0.0872809716387958 110 4293482 SGTC_2141 5621638 7.665 µM 1.35241832034092 0.153523291189257 no 557 0.0881207659899672 104 2856238 SGTC_2943 9068529 45.32 µM 1.34871547800494 0.1542088047668 no 558 0.088714186022162 146 3270634 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.34594067242577 0.1547238342701 no 559 0.0891608252710858 106 4213774 SGTC_1809 st050081 57.6 µM 1.34341096038877 0.155194361407082 no 560 0.0895694699049685 122 5036894 SGTC_868 0527-0199 213 µM 1.34303477848041 0.15526441193735 no 561 0.0896303563430477 121 2849450 SGTC_2031 5180455 200 µM 1.34077301900099 0.155686024259339 no 562 0.0899970793893053 113 29949 SGTC_3275 9138069 49.47 µM 1.33695385140894 0.156399663789554 no 563 0.0906188505209203 120 17617007 SGTC_1151 3909-8316 15.3 µM 1.33327605710208 0.157088919705801 no 564 0.0912206139635341 120 800431 SGTC_2353 9059630 146.67 µM 1.32996106970058 0.157711891242722 no 565 0.0917655491827618 109 4779114 SGTC_755 1995-0008 37.3 µM 1.32627575221242 0.158406359707354 no 566 0.0923741877465021 80 689533 SGTC_118 0083-0097 135.343 µM 1.3250048339799 0.158646318525121 no 567 0.0925847740075446 172 5207356 SGTC_529 4076-0302 30.3 µM 1.32474281070755 0.158695820087599 no 568 0.092628234376833 112 5816522 SGTC_901 1112-0062 60.1 µM 1.32345395246192 0.158939459204669 no 569 0.0928422299398852 109 1908457 SGTC_1327 1436-0082 2.18 µM 1.31774257734733 0.160022056319206 no 570 0.0937949181550203 131 15992205 SGTC_3356 9151811 4.48 µM 1.3140221926352 0.160729846602964 no 571 0.0944193680051388 128 1859254 YPR165W RHO1 SGTC_2319 6033012 152.6 µM 1.31307306597127 0.160910741454201 no 572 0.0945791643352327 120 847246 SGTC_2000 st075254 36.4 µM 1.31138161403944 0.161233446031792 no 573 0.0948644336868281 109 17234175 SGTC_3005 9076496 71.4286 µM 1.30724802084704 0.162023851193354 no 574 0.0955642456394394 112 21368410 SGTC_408 cantharidin 100 µM 1.30571292535842 0.162318026108742 no 575 0.0958251004023665 121 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_993 3909-8757 62.7 µM 1.3051601302791 0.162424044965655 no 576 0.0959191635728266 102 4288324 YLR208W SEC13 SGTC_535 2293-4129 48.2 µM 1.3039347862561 0.162659210531983 no 577 0.0961279091954249 156 396118 YIL048W NEO1 SGTC_2280 7785178 200 µM 1.29679679888869 0.164033519446681 no 578 0.0973505562090726 115 2954328 SGTC_1667 st014849 34.6 µM 1.2951167020531 0.164358088092415 no 579 0.0976399870300596 127 5348460 SGTC_412 gemfibrozil 100 µM 1.29434056251979 0.164508166713204 no 580 0.0977739057010955 110 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.29015344397252 0.165319342563239 no 581 0.0984986934676781 115 4620898 SGTC_560 2332-1943 155 µM 1.28993946833693 0.165360865733654 no 582 0.0985358378927564 121 21177716 SGTC_3201 9113999 49.47 µM 1.2891584101129 0.165512491722415 no 583 0.0986715102644915 116 16649224 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.28804966045373 0.165727886483804 no 584 0.0988643384471253 118 5711223 A potent inhibitor of glutathione S-transferases. SGTC_32 0928-0142 34.1 µM 1.28787822947095 0.165761206236241 no 585 0.0988941774589411 131 2244242 SGTC_2152 5568786 200 µM 1.28782910011767 0.165770755937987 no 586 0.0989027300528523 132 5399883 SGTC_1496 4469-0713 57.4 µM 1.28691243817977 0.165949000756631 no 587 0.0990624047311174 122 746691 SGTC_1921 5740136 50 µM 1.28657084183755 0.166015455797013 no 588 0.0991219560950777 98 1774243 SGTC_2243 6634756 200 µM 1.28565478714296 0.166193752335939 no 589 0.0992817834941258 93 885676 SGTC_360 0957-0399 1.01 µM 1.28556856984917 0.166210539627099 no 590 0.0992968358355367 123 6752301 YPR165W RHO1 SGTC_957 1187-1561 14.1 µM 1.28550744768176 0.166222441332393 no 591 0.0993075079272895 124 1538454 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.28308532102729 0.166694520800375 no 592 0.099731092943327 164 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_603 3794-0023 45.9 µM 1.28128452600927 0.167046061112557 no 593 0.100046873012552 131 3802260 SGTC_653 0203-0016 55.2 µM 1.2807744807437 0.167145715877866 no 594 0.100136445002355 141 295302 SGTC_2256 7954252 200 µM 1.28002753664264 0.167291726074728 no 595 0.100267725791931 122 2972920 SGTC_2003 4023581 200 µM 1.27686546281549 0.167910748260215 no 596 0.100824874603542 107 16641307 SGTC_1668 st014914 51.6 µM 1.27546536023149 0.168185309177686 no 597 0.101072288647998 145 2839556 SGTC_2753 fluvastatin 17.09 µM 1.27539877545086 0.168198373682025 no 598 0.101084065948816 139 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_421 streptovitacin 30 mM 1.27506206262272 0.168264449621714 no 599 0.101143637943989 128 91467 include heat shock SGTC_2395 5646831 180.19 µM 1.27396158796208 0.168480521301582 no 600 0.101338514863498 140 6808628 SGTC_887 0885-0007 9.62 µM 1.27384785040097 0.168502863165465 no 601 0.101358671599983 137 5719458 SGTC_2114 5491910 81.25 µM 1.27152973575269 0.168958633481918 no 602 0.101770127854139 123 2849228 SGTC_652 0437-0092 114 µM 1.26601791553866 0.170045502840628 no 603 0.102753334112307 126 3091274 SGTC_2043 5101342 149 µM 1.25624516274406 0.171983570447204 no 604 0.104513548518351 138 678451 SGTC_74 000s-0487 160.283 µM 1.2534193096869 0.172546593035451 no 605 0.105026573864984 109 677548 SGTC_2730 imipramine 71.33 µM 1.25213291601507 0.172803282806258 no 606 0.105260717672991 125 3696 A tricyclic antidepressant. SGTC_3048 9093155 49.47 µM 1.25128558313313 0.172972494323889 no 607 0.105415151714806 114 25236002 SGTC_575 k072-0246 11.9 µM 1.25091863492404 0.173045806256434 no 608 0.105482082159738 137 6796779 SGTC_203 k066-0004 30.888 µM 1.24857730243771 0.173514042895812 no 609 0.105909859183542 160 6795412 SGTC_143 4032-1194 15.74 µM 1.24584157570351 0.174062173851108 no 610 0.10641128132473 155 1806963 SGTC_2434 5670830 169.91 µM 1.24444044805709 0.174343329946407 no 611 0.106668752067981 143 1549830 SGTC_42 0133-0086 60.653 µM 1.24417495281063 0.174396637824364 no 612 0.106717590013272 171 162923 Model of phenazepam hydroxylation. SGTC_2425 5628681 7.85 µM 1.24332506497259 0.174567353499819 no 613 0.106874035688484 130 5714958 SGTC_2068 5226020 147 µM 1.2430502364481 0.174622580586525 no 614 0.106924660968518 135 1810509 SGTC_180 1486-1293 102.781 µM 1.2391547274141 0.175406580120405 no 615 0.107644101422027 137 4140536 SGTC_1848 st056003 16.4 µM 1.23552258052876 0.176139583074175 no 616 0.108318038983112 131 146492 SGTC_1590 st077108 57.8 µM 1.23264515781865 0.176721649649287 no 617 0.108854090585357 118 5489485 SGTC_1548 st061468 90.8 µM 1.23047969222001 0.177160497227759 no 618 0.109258763547016 119 390799 SGTC_1484 3473-2379 286 µM 1.22946614044362 0.177366137260997 no 619 0.109448542663791 118 671917 SGTC_2770 toltrazuril 17.5 µM 1.22430968642021 0.178414665182206 no 620 0.110417712114143 123 68591 Kills coccidiodes. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.22365531969253 0.178548004632322 no 621 0.110541140711741 151 688788 SGTC_3351 9150312 21.596 µM 1.22355069322104 0.178569330049662 no 622 0.110560884835214 150 4904905 SGTC_2714 st079313 56.9 µM 1.22343721593703 0.178592461291024 no 623 0.110582302058284 122 2939799 SGTC_144 4161-2749 112.381 µM 1.22186551418867 0.178913031456251 no 624 0.110879244275477 158 797501 YMR168C CEP3 SGTC_3247 9135149 49.47 µM 1.21889820927031 0.179519240593993 no 625 0.11144141472059 161 8934436 YOR116C RPO31 SGTC_1402 3909-7673 35.9 µM 1.21502578494308 0.180312301501563 no 626 0.112178128565874 132 5328014 SGTC_3285 9112818 20.8695 µM 1.21399208331181 0.180524371696067 no 627 0.11237537363633 176 17017947 YPR165W RHO1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.21324282996327 0.180678183341904 no 628 0.112518496720386 156 5024745 SGTC_3115 9123671 49.47 µM 1.21294768043588 0.180738796128285 no 629 0.112574912196488 144 3286988 SGTC_599 1935-0052 86.5 µM 1.21245645343758 0.18083970422966 no 630 0.112668851104785 115 9557311 SGTC_452 diindolylmethane 8 µM 1.21124221834414 0.181089284513594 no 631 0.112901293328484 129 3071 Inhibits expression of several cancer promoting factors. SGTC_1094 duloxetine 25.4 µM 1.21018820404157 0.181306107042243 no 632 0.113103341698824 127 60834 A selective serotonin reuptake inhibitor. SGTC_1170 0310-0127 64.8 µM 1.20431989621996 0.18251625368431 no 633 0.114232979745787 157 774975 SGTC_1231 0242-0792 125 µM 1.20381859414279 0.182619864225623 no 634 0.114329850626563 136 3707635 SGTC_2558 carylophyllene oxide 100 µM 1.20365409228967 0.182653871939562 no 635 0.114361651466756 139 6708694 An oxygenated terpenoid and antifungal agent. SGTC_223 busulfan 5 mM 1.2036039892224 0.182664230607111 no 636 0.114371338442361 120 2478 A DNA alkylator. SGTC_2273 7815444 169.05 µM 1.19936582661527 0.183541786269754 no 637 0.115192864711262 154 2824616 SGTC_3056 9094900 49.47 µM 1.19928743121653 0.183558043564849 no 638 0.115208100307101 134 25236784 SGTC_708 3448-5400 146 µM 1.19879476889519 0.183660230263424 no 639 0.115303878562896 177 3462195 SGTC_94 0334-0113 514.748 µM 1.19791954765947 0.18384185370538 no 640 0.11547416947744 141 6795178 SGTC_1090 efavirenz 20.7 µM 1.19510587433309 0.184426496800722 no 641 0.116022833579125 139 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_864 0469-0573 172 µM 1.19484004579256 0.18448179209485 no 642 0.116074765455859 150 689425 SGTC_3220 9131269 49.47 µM 1.19468919708763 0.18451317488958 no 643 0.116104242376242 133 17722206 SGTC_516 3992-2719 87.3 µM 1.19441327917018 0.184570585864617 no 644 0.1161581724652 103 5350887 YDR037W KRS1 SGTC_973 1325-0077 65.9 µM 1.19354270708682 0.184751800923912 no 645 0.116328448408814 133 2835149 SGTC_761 k216-0224 480 µM 1.19141802565166 0.185194530895451 no 646 0.116744759997577 157 1340404 SGTC_1633 st005664 67.9 µM 1.18794847035011 0.185918913739857 no 647 0.117426855901395 134 2063822 SGTC_92 0063-0024 660.874 µM 1.18729943232144 0.186054616421531 no 648 0.117554765974084 129 3594437 SGTC_2210 7115885 190.385 µM 1.18538383057784 0.186455493706127 no 649 0.117932860931628 136 2927039 SGTC_1646 st011709 75.6 µM 1.18290066306386 0.186975940828805 no 650 0.11842425942169 149 5757843 SGTC_2734 clemastine 41.6 µM 1.1815960482842 0.187249734853791 no 651 0.118683011142735 152 26987 Clemastine is a selective histamine H1 antagonist. SGTC_857 0438-0306 1.35 µM 1.1808387992086 0.187408769184664 no 652 0.118833383771346 136 4686136 SGTC_463 ikarugamyin 104 µM 1.18076830456119 0.187423578426805 no 653 0.118847389266119 103 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1768 st044301 37.178 µM 1.1803622570154 0.187508893402016 no 654 0.118928083291613 181 3931349 SGTC_1746 st038117 42 µM 1.17495968158032 0.188646315738265 no 655 0.120005423281067 147 2898218 SGTC_1487 3970-0795 2.82 µM 1.1721212522597 0.189245600486944 no 656 0.120574189281052 147 3765103 SGTC_1389 3405-0187 19 µM 1.1707262755735 0.18954055453134 no 657 0.120854410024311 138 799890 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.17032333288936 0.189625805405768 no 658 0.120935437770333 143 23847180 SGTC_1017 4239-0030 168 µM 1.16887858642778 0.189931665317373 no 659 0.121226276064457 144 1149593 SGTC_2224 6650123 117.647 µM 1.16731859018706 0.190262264501517 no 660 0.121540866956154 138 2908370 SGTC_2945 9067681 61.76 µM 1.16721787625804 0.190283620247157 no 661 0.121561196760728 176 16456930 SGTC_2818 7996756 12.99 µM 1.16409134877897 0.190947312633473 no 662 0.122193497106 153 2241621 SGTC_1863 st057641 20.1 µM 1.16331509205492 0.191112314488239 no 663 0.122350842315555 156 3921635 SGTC_1200 1643-0193 18.4 µM 1.16273282417522 0.191236139260574 no 664 0.122468959795792 164 5403974 SGTC_1220 1838-0075 193 µM 1.16167793236491 0.191460597210374 no 665 0.122683156399805 135 5529645 SGTC_633 0437-0093 97.7 µM 1.16111895146505 0.19157960154729 no 666 0.122796764363304 141 2831118 SGTC_1277 0873-0036 22 µM 1.15977237844987 0.191866466438045 no 667 0.123070746403911 150 5965735 SGTC_1214 0358-0031 63.7 µM 1.15888197495372 0.192056296377438 no 668 0.123252148565416 153 4301366 SGTC_2669 eugenol 100 µM 1.15810829760247 0.192221334119954 no 669 0.123409922136817 104 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.15730546999181 0.192392681764266 no 670 0.12357378975093 158 6728940 SGTC_1141 3253-0389 52.6 µM 1.15687978767378 0.192483573097316 no 671 0.123660738871734 156 5402031 SGTC_2489 cantharidin 73.42 µM 1.15648331316149 0.192568251610946 no 672 0.123741760579975 146 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1065 prochlorperazine maleate 2.48 µM 1.15621546788134 0.192625470544823 no 673 0.123796517240365 164 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2083 5306046 65.942 µM 1.15444957045605 0.193002973612086 no 674 0.124157951146197 144 539837 SGTC_2416 tofa 880 nM 1.15289224471269 0.193336264072932 no 675 0.124477307820956 126 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_208 k072-0098 12.366 µM 1.15226907376101 0.193469730088112 no 676 0.124605260597934 155 5948901 SGTC_561 1550-0330 72.9 µM 1.15107085602692 0.193726513134263 no 677 0.124851543317473 156 6812934 SGTC_1515 3460-0031 42.1 µM 1.14968745012451 0.19402324108325 no 678 0.12513631256013 156 2876596 SGTC_2572 astragaloside iv 100 µM 1.14854792372457 0.194267866977748 no 679 0.125371220518604 144 45006101 An anti-inflammatory agent. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.144922204622 0.19504746072765 no 680 0.126120692479456 135 1241132 A phosphatase inhibitor. SGTC_2893 9048488 25.97 µM 1.14394026976372 0.19525892093113 no 681 0.12632420448965 163 6467338 SGTC_3283 9109332 35.8195 µM 1.14255490192634 0.195557497445465 no 682 0.12661171946297 126 17027281 SGTC_828 2074-0507 139 µM 1.14160709567841 0.195761929672537 no 683 0.126808686635081 150 X828 SGTC_2123 5259487 200 µM 1.13631765246918 0.196905189141315 no 684 0.127911822770366 148 2173474 SGTC_2098 5376439 882.5 nM 1.1362722101657 0.196915028514069 no 685 0.127921328757714 146 2844116 SGTC_3305 9127027 53.8275 µM 1.13363738560547 0.197486041487281 no 686 0.128473342108238 165 41905295 SGTC_1873 rapamycin 2 nM 1.13290505017528 0.197644929128033 no 687 0.128627064495185 142 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1662 st014054 52 µM 1.13237271351069 0.197760473477205 no 688 0.128738885807241 143 2838777 SGTC_211 3455-0679 143.504 µM 1.1320323701163 0.197834366828524 no 689 0.128810412825906 125 748649 SGTC_3163 9099914 49.47 µM 1.13114922105714 0.198026188733797 no 690 0.128996145166426 176 16268368 SGTC_106 0092-0003 11.579 µM 1.12994034328878 0.198288941653892 no 691 0.129250681470783 143 1072148 SGTC_137 0438-0332 85.389 µM 1.12967311800992 0.198347052191232 no 692 0.129306994272148 186 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1843 st055809 45.5 µM 1.12950705595821 0.198383169053161 no 693 0.129341997353939 141 16413835 SGTC_1954 st077032 68.9 µM 1.12867515589504 0.198564158857302 no 694 0.129517446709542 162 698907 SGTC_3131 9127911 49.47 µM 1.12745531623651 0.198829729582668 no 695 0.129775011318432 147 45595681 SGTC_961 1252-1571 372 µM 1.12509241636573 0.199344764110186 no 696 0.130274937285113 156 6813498 SGTC_840 0245-0196 390 µM 1.12305493276278 0.199789512913886 no 697 0.13070708242203 152 3827528 SGTC_2934 9036370 36.88 µM 1.12066636291337 0.200311657312075 no 698 0.13121495264489 134 6462800 SGTC_2060 5238662 140 µM 1.12054541458046 0.200338118561806 no 699 0.13124070551655 147 790130 SGTC_2214 7179297 48.276 µM 1.12044070130111 0.200361029579286 no 700 0.131263004365546 144 769744 SGTC_1135 dihydrocapsaicin 536.708 nM 1.12015745332019 0.200423011453616 no 701 0.131323335556202 165 107982 A Capsaicinoid. SGTC_2390 9097792 176.6 µM 1.11517142830807 0.201515965488104 no 702 0.132388483629364 143 4497149 SGTC_2887 9044784 58.44 µM 1.11424956238557 0.201718432185033 no 703 0.132586069153431 183 6465546 SGTC_107 0358-0022 2.6945 µM 1.11307672139546 0.201976195820891 no 704 0.132837740225396 145 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1776 st049249 45.9 µM 1.10977074054053 0.202703835187508 no 705 0.133548915349629 168 1822314 SGTC_827 3253-0474 693 µM 1.10791974988926 0.20311191746254 no 706 0.13394823765455 166 5402065 SGTC_2710 st078562 53.7235 µM 1.10619142035932 0.203493399463032 no 707 0.134321837798617 165 17250908 SGTC_1935 st074532 41.6 µM 1.10484790745679 0.203790238632334 no 708 0.134612748878057 173 2829742 SGTC_508 roscovitine 141 µM 1.10470209454422 0.203822470428807 no 709 0.134644347766522 180 160355 A CDKinase inhibitor. SGTC_385 1494-0393 12.4 µM 1.10454674735787 0.203856813109715 no 710 0.134678018413065 159 3090647 SGTC_2345 9052315 157.45 µM 1.10424999558448 0.203922425759715 no 711 0.134742353785502 154 6469265 SGTC_2289 7946404 165.07 µM 1.10362320602307 0.204061052045827 no 712 0.134878310195229 176 1246120 YPR165W RHO1 SGTC_2432 5630864 12.22 µM 1.10351680647877 0.204084589876449 no 713 0.134901398573401 155 5714970 SGTC_1761 st044296 37 µM 1.10219433916061 0.204377282586693 no 714 0.135188596244046 169 1826700 SGTC_496 calpeptin 138 µM 1.10154802028651 0.204520418813322 no 715 0.135329108458037 145 73364 A calpain inhibitor. SGTC_3318 9139014 38.6185 µM 1.10115143407226 0.204608277824936 no 716 0.135415377371039 178 16643984 SGTC_2849 9019321 12.99 µM 1.1004041567978 0.204773889326454 no 717 0.135578034079128 151 16489627 SGTC_395 anisomycin 6.25 µM 1.09975203663755 0.204918477242543 no 718 0.135720087671985 166 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1412 3909-8563 178 µM 1.09807641265779 0.205290274419839 no 719 0.136085562042359 175 23767530 SGTC_1372 2752-0194 270 µM 1.09515267567265 0.205939968970127 no 720 0.136724877288819 141 823334 SGTC_1949 st076024 69.1 µM 1.09493931191312 0.205987429032136 no 721 0.136771612464292 189 2921930 SGTC_2850 9015429 58.44 µM 1.0915720468715 0.206737293101991 no 722 0.137510624126771 174 6457570 SGTC_1629 st005085 44.9 µM 1.08889425816134 0.207334768165206 no 723 0.138100259293696 187 24207091 SGTC_1625 st003711 30.1 µM 1.08859452862358 0.20740170806033 no 724 0.138166365313749 152 24207034 YER133W GLC7 SGTC_890 0929-0006 47.2 µM 1.08682476261992 0.207797217923025 no 725 0.138557130944181 149 1378169 SGTC_2536 dehydroabietamide 32.04 µM 1.08672968535634 0.207818478528432 no 726 0.13857814536613 143 3983547 SGTC_231 b-estradiol 524 µM 1.08429554887414 0.208363222820524 no 727 0.139116889113237 156 450 A steroid. SGTC_2205 7238770 200 µM 1.08170933865647 0.208942922072613 no 728 0.13969085112646 147 279867 SGTC_625 k213-0058 121 µM 1.08009165348397 0.209306008829742 no 729 0.140050684129886 194 3655420 SGTC_2383 9036125 200 µM 1.07748646387673 0.20989151924812 no 730 0.140631497413204 167 79580 SGTC_2634 4'-methoxyflavone 100 µM 1.07576665805833 0.210278568646497 no 731 0.141015813661789 148 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1030 k029-0042 36.7 µM 1.07238407755813 0.2110410540381 no 732 0.141773778313525 156 6080581 SGTC_2355 9061122 103.12 µM 1.07141434661297 0.211259944772275 no 733 0.141991582442745 186 5302957 SGTC_2870 9038528 12.99 µM 1.06970611214323 0.211645856216431 no 734 0.142375807137669 160 6463316 SGTC_2593 nobiletin 86.24 µM 1.0667112202044 0.21232343459044 no 735 0.143051129446617 148 72344 An anti-infammatory. SGTC_517 1365-0151 113 µM 1.06519795508014 0.212666284330273 no 736 0.143393179409816 155 768657 SGTC_3122 9126309 49.47 µM 1.0646879596173 0.212781903176105 no 737 0.143508580239807 198 17591206 SGTC_823 0417-1665 178 µM 1.06369238731642 0.213007710731426 no 738 0.143734037105611 173 3429856 SGTC_860 0443-0016 25.1 µM 1.06278719649225 0.21321314000004 no 739 0.143939233557183 190 5337942 SGTC_684 1140-0066 328 µM 1.06168602158931 0.213463202739481 no 740 0.144189123639102 167 6813534 SGTC_3150 9097574 49.47 µM 1.05996197691156 0.213855054355238 no 741 0.144580948936162 156 17217476 SGTC_1816 st051957 91.6 µM 1.05957475137885 0.213943122954453 no 742 0.144669052613263 156 674121 SGTC_3274 9138298 49.47 µM 1.05933047502827 0.213998690780431 no 743 0.144724650306733 188 17015756 SGTC_27 0485-0001 32.618 µM 1.05853696358356 0.214179256210294 no 744 0.144905354087806 169 2054479 SGTC_2357 9067248 200 µM 1.05764490972419 0.214382351007209 no 745 0.145108679917944 164 9150235 SGTC_1521 st012942 49.4 µM 1.05756053605564 0.214401566240852 no 746 0.14512792114224 161 24207259 SGTC_1468 k284-1086 134 µM 1.05645674251707 0.214653036087788 no 747 0.145379796924431 177 15996457 SGTC_1963 st076565 50.3 µM 1.05547350979036 0.214877183665051 no 748 0.145604409299988 186 4914280 SGTC_3121 9125696 49.47 µM 1.05312825112168 0.215412380900742 no 749 0.146141108237958 166 1235365 SGTC_1431 4049-0260 9.09 µM 1.05188177015765 0.21569714719927 no 750 0.14642689836113 188 3854841 SGTC_202 3594-0513 34.79 µM 1.05094354538345 0.215911634345496 no 751 0.146642259585971 162 708429 SGTC_3331 9141060 1.957 µM 1.050042972729 0.216117630054797 no 752 0.146849177935832 158 4906567 YPR165W RHO1 SGTC_1444 4112-3581 28 µM 1.0474715156463 0.216706447621959 no 753 0.147441081421825 181 2877249 SGTC_2611 pyromycin 23.93 µM 1.04550566033931 0.217157218339629 no 754 0.14789466293693 165 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2588 indole-3-carbinol 100 µM 1.04429264046943 0.217435633888987 no 755 0.148175008401514 171 3712 Induces cell cycle arrest. SGTC_1335 1486-0900 202 µM 1.04362368615582 0.217589262182934 no 756 0.148329764901268 154 X1335 SGTC_2839 9003951 25.97 µM 1.04362275233177 0.2175894766835 no 757 0.148329981008514 161 2990634 SGTC_1975 st070967 30.8 µM 1.04304215999268 0.217722863100841 no 758 0.148464383506979 215 261391 SGTC_2373 9071805 200 µM 1.04296140653722 0.217741419293584 no 759 0.14848308373767 169 10149009 SGTC_2780 5215298 71.43 µM 1.04204368240295 0.217952365580753 no 760 0.148695713517457 197 2834131 SGTC_2838 9002687 71.43 µM 1.04063494670254 0.218276403995776 no 761 0.149022502812161 189 6457060 SGTC_2706 st078239 82.5 µM 1.04056861780335 0.218291667856685 no 762 0.149037901173844 181 15434492 SGTC_1565 sinapyl alcohol 95.1 µM 1.04035024458567 0.218341925084704 no 763 0.149088604380674 187 5280507 A phenol propionate derived from cinnamic acid. SGTC_2133 5320837 200 µM 1.03974196640246 0.218481951634453 no 764 0.149229898805522 138 2841355 SGTC_1669 st015249 58.4 µM 1.03940362511732 0.218559860682345 no 765 0.149308529392714 164 722793 SGTC_3040 9091894 49.47 µM 1.03857786150347 0.21875007446251 no 766 0.149500553157154 159 25236966 SGTC_1824 st053723 68.6 µM 1.03779595279503 0.218930274093522 no 767 0.14968253072653 163 675225 SGTC_613 3914-0030 117 µM 1.03370860715002 0.21987363749292 no 768 0.150636204042324 134 1145395 SGTC_735 3076-0345 636 µM 1.03305079105231 0.220025679743822 no 769 0.150790065115383 175 2888990 SGTC_2086 5274770 176.623 µM 1.03270401858271 0.220105854179356 no 770 0.150871216183661 172 689278 SGTC_1755 st041960 45.185 µM 1.03138879408191 0.220410088775649 no 771 0.151179266838174 194 2257073 SGTC_2097 5376186 200 µM 1.03052080782343 0.220611001241163 no 772 0.151382794810433 166 742755 SGTC_960 1222-0186 7.7 µM 1.02990624918772 0.220753316324984 no 773 0.151527008456782 177 3126296 SGTC_2047 4141938 200 µM 1.02628307127292 0.221593413875144 no 774 0.152379087230093 200 3807862 SGTC_891 0929-0073 133 µM 1.02141939137782 0.222724011113865 no 775 0.153527890968956 191 5603632 SGTC_1243 0416-0003 5.65 µM 1.021280763155 0.222756284352796 no 776 0.153560718882315 166 2141977 SGTC_748 act1.228 77.9 µM 1.02127992596228 0.222756479262913 no 777 0.153560917148202 160 4421505 YNR035C ARC35 SGTC_2528 xanthyletin 44.79 µM 1.02106815851622 0.22280578479284 no 778 0.153611073841678 180 65188 An natural product with antifungal activity of unknown mechanism. SGTC_819 1013-0258 27.7 µM 1.02073665328434 0.222882981196048 no 779 0.153689611968411 186 5753198 SGTC_2364 9055074 200 µM 1.0167890359115 0.223803418652278 no 780 0.154626899504297 156 6470630 SGTC_2563 tomatine 8.54 µM 1.01570172153223 0.224057318892596 no 781 0.154885723996623 176 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.01436168171487 0.224370458362808 no 782 0.155205100733199 153 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1892 st058411 7.36 µM 1.01419619865807 0.224409145540715 no 783 0.155244571068958 172 3934738 SGTC_2316 5844804 197.44 µM 1.0137128297476 0.22452217080564 no 784 0.155359900164347 197 776813 SGTC_1797 st048695 56.8 µM 1.01318870285941 0.224644762925439 no 785 0.155485017758373 198 592262 YIL048W NEO1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.01158283127744 0.225020609022585 no 786 0.155868779128972 191 66535 A nucleotide analog. SGTC_1615 st002656 86.5 µM 1.01107876174322 0.225138657381222 no 787 0.155989367240333 163 1584458 SGTC_1351 1496-0003 46.5 µM 1.00932403842991 0.225549870665468 no 788 0.156409627633247 189 3891978 SGTC_2642 cholecalciferol 100 µM 1.00896173375801 0.225634828413819 no 789 0.156496493248967 157 9821465 A vitamin D precursor, similar to steriods. SGTC_1471 k673-0312 37 µM 1.00847219639994 0.225749650036495 no 790 0.156613914427447 189 24099884 SGTC_942 3253-1115 227 µM 1.00715231203213 0.22605939526494 no 791 0.156930792829217 196 46497897 SGTC_389 tpck 16.7 µM 1.00396739185344 0.226807808025551 no 792 0.157697165578809 160 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_338 4055-0136 114 µM 1.0034797022567 0.226922531709289 no 793 0.157814732782764 161 2900563 SGTC_719 2810-4230 27.3 µM 0.999708398792895 0.227810794252095 no 794 0.158725823174349 176 721079 SGTC_2193 5925765 200 µM 0.998614997557793 0.228068690614043 no 795 0.158990616053749 168 877370 SGTC_2691 st077356 60.2 µM 0.99691747994274 0.228469402731251 no 796 0.159402283135667 183 2839272 SGTC_992 3909-8734 162 µM 0.993977944351075 0.229164237393921 no 797 0.160116802626194 171 4288319 SGTC_479 n-linoleoylglycine 10 µM 0.992449089423786 0.229526089451864 no 798 0.160489251300438 196 6433346 An anti-infammatory. SGTC_1957 st077035 62.4 µM 0.990496947996851 0.22998859071863 no 799 0.160965640090818 189 705593 SGTC_1029 k015-0030 64.7 µM 0.989966812098987 0.230114280488464 no 800 0.16109517044685 191 2208316 SGTC_1193 1488-0126 41.5 µM 0.987944392827508 0.230594128087449 no 801 0.161589941236518 179 1384710 SGTC_133 0724-0033 378.92 µM 0.986147449961947 0.231020946909102 no 802 0.16203038101742 185 280309 SGTC_2582 agaric acid 100 µM 0.985843779785162 0.231093119695565 no 803 0.162104889274912 209 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1674 st016616 23.6 µM 0.985322112964858 0.231217132752714 no 804 0.162232937084065 176 625830 SGTC_1670 st016595 4.04 µM 0.984082575267611 0.231511950277119 no 805 0.162537456812873 216 597879 SGTC_2325 6158266 200 µM 0.980115752748572 0.23245684521313 no 806 0.163514492071182 170 3623240 SGTC_1027 k015-0025 8.67 µM 0.979940226913629 0.232498704862438 no 807 0.163557812324774 186 3598955 SGTC_590 k048-0076 22.4 µM 0.97855082863568 0.232830198395456 no 808 0.163900982547591 192 6832814 SGTC_2618 avocadyne 43.43 µM 0.978418279322531 0.232861836765 no 809 0.163933745559929 167 3015189 SGTC_340 k038-0059 454 µM 0.978115912334127 0.232934018076284 no 810 0.164008499332805 200 23733424 SGTC_3250 9135583 49.47 µM 0.976848848192486 0.233236627851943 no 811 0.164321994318643 173 7699353 SGTC_739 1486-1183 203 µM 0.976317694728334 0.233363546787715 no 812 0.164453526955835 179 4346692 SGTC_2529 gangaleoidin 93.61 µM 0.974105337295309 0.233892600820607 no 813 0.165002119860058 193 4565183 SGTC_124 0136-0217 7.121 µM 0.973958246242347 0.233927799114163 no 814 0.165038635633049 216 3976905 SGTC_1309 pyrazolanthrone 13.4 µM 0.973733835864933 0.233981505262728 no 815 0.165094356228124 197 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2303 7774051 200 µM 0.972093012738159 0.234374396410999 no 816 0.165502138953488 187 2953184 SGTC_1849 st056239 19.2 µM 0.970311544773497 0.234801377677075 no 817 0.165945612223247 198 5393181 SGTC_844 0330-0132 15.3 µM 0.968255185748765 0.23529477885802 no 818 0.166458470000446 195 2828079 SGTC_801 0866-0028 10.1 µM 0.968111319583544 0.235329319404102 no 819 0.166494388609549 190 6849771 SGTC_1474 0330-0125 5.35 µM 0.960114162477347 0.237253737101963 no 820 0.168498880699708 185 X1474 SGTC_3299 9121982 43.1275 µM 0.959922135871951 0.23730005197059 no 821 0.168547202266358 179 17594604 YPL160W CDC60 SGTC_3352 9151559 45.5865 µM 0.959319181073158 0.237445510817034 no 822 0.168698987683622 178 17159339 SGTC_91 0417-1751 58.384 µM 0.955394667861862 0.238393468685829 no 823 0.169689074737767 203 6795624 SGTC_51 1013-0126 23.419 µM 0.951429012874493 0.239353465595958 no 824 0.170693319091835 170 1627850 SGTC_1676 st018489 23.4 µM 0.951016186702218 0.239453522842304 no 825 0.17079807949446 184 3696235 SGTC_518 1021-0119 62.6 µM 0.95079860435272 0.239506267765294 no 826 0.170853310606942 208 1097762 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.950031619344377 0.239692245952633 no 827 0.171048093248335 192 688662 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.948803398257568 0.239990228539823 no 828 0.171360306604577 196 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1475 4092-1048 11.7 µM 0.947082773732189 0.240408014167237 no 829 0.171798300953021 188 2881759 SGTC_2608 thymoquinone 42.66 µM 0.9461896901248 0.240625020279988 no 830 0.172025921867026 194 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1187 1391-0724 117 µM 0.946100622864266 0.240646668153485 no 831 0.172048633061665 186 6997986 SGTC_1436 4092-1007 8.32 µM 0.945058818716754 0.240899958242751 no 832 0.172314424040021 170 2881121 SGTC_1369 1866-0067 208 µM 0.940364011694522 0.242043186970186 no 833 0.173515437760678 181 3531355 SGTC_484 loperamide 105 µM 0.939721154284492 0.242199957369153 no 834 0.173680305632815 154 3955 An opioid-receptor agonist. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.938956395107582 0.242386527003692 no 835 0.173876566313675 183 94937 An inhibitor of serotonin biosynthesis. SGTC_2592 piperlongumine 83.33 µM 0.93751528518311 0.242738309785421 no 836 0.17424678248695 213 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2617 dihydrotanshinone i 20.83 µM 0.937340434035083 0.242781010694779 no 837 0.174291735194775 206 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2328 6201408 200 µM 0.936327717780901 0.243028409033795 no 838 0.17455224064398 212 2890418 SGTC_1375 2910-0797 186 µM 0.936200408045658 0.243059519411337 no 839 0.174585006573664 207 742508 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.934285196721094 0.243527794869885 no 840 0.175078399143916 190 688667 SGTC_1767 st044992 70.3 µM 0.934214408882745 0.243545112062352 no 841 0.175096652287766 208 9600693 SGTC_2979 9012552 45.46 µM 0.932996538902536 0.243843149980956 no 842 0.175410877687645 226 17100905 SGTC_1222 0366-0074 1.18 µM 0.932778395724636 0.243896554897008 no 843 0.175467199031901 209 286520 SGTC_2639 lactacystin 53 µM 0.932750212295971 0.243903455108511 no 844 0.175474476412668 194 3870 A proteasome inhibitor. SGTC_2917 7979103 53.79 µM 0.93113934250362 0.244298022959998 no 845 0.175890744908323 179 2980565 SGTC_2115 tiliquinol 12.7705 µM 0.931034304307658 0.244323763050603 no 846 0.175917909767213 200 71208 A bioactive hydroxyquinoline. SGTC_2239 6685329 187.64 µM 0.929709317958365 0.24464858250054 no 847 0.176260804342566 173 805680 SGTC_11 0438-0307 1.3 µM 0.928987430972862 0.244825650389672 no 848 0.176447800087109 212 4011476 SGTC_1129 3453-1384 223 µM 0.92754847171077 0.245178810884577 no 849 0.176820918621873 205 1084452 SGTC_284 0988-0104 32.6 µM 0.926145259431127 0.245523461719353 no 850 0.177185247973926 216 4666532 SGTC_1131 3454-3128 32.3 µM 0.925755931555756 0.245619132826137 no 851 0.177286416840719 185 710982 SGTC_656 4090-1979 187 µM 0.925334695394692 0.245722667431132 no 852 0.177395918316995 204 22330961 SGTC_1904 st060225 78 µM 0.924261552568737 0.245986538437881 no 853 0.177675077597715 185 66595 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.919297130474074 0.24720919724654 no 854 0.178970089168506 201 688761 SGTC_1181 1222-0449 220 µM 0.919221857782774 0.247227760700055 no 855 0.178989770289709 198 658318 SGTC_1753 st043925 64 µM 0.916220120538092 0.247968644431892 no 856 0.179775727210043 198 670181 SGTC_1208 2323-2347 50.3 µM 0.913549502504842 0.248628796520239 no 857 0.180476805459949 196 5412760 SGTC_1008 4106-0037 6 µM 0.912626071725188 0.248857277688281 no 858 0.18071961871493 228 2905394 SGTC_1832 st054113 55 µM 0.912248884635692 0.248950635878459 no 859 0.180818857777528 189 1251267 SGTC_3148 9097893 49.47 µM 0.910254899160057 0.249444480020427 no 860 0.181344048826875 189 17174100 SGTC_3210 9128157 49.47 µM 0.909941089111071 0.249522247761383 no 861 0.18142678940514 184 17590849 SGTC_3227 9130768 49.47 µM 0.909612785624707 0.249603621021798 no 862 0.181513376680764 200 17720899 SGTC_1205 4161-2785 76 µM 0.90815048045316 0.249966238960947 no 863 0.181899361443557 182 3498106 SGTC_5 0352-0601 109.883 µM 0.90788088886717 0.250033121961567 no 864 0.181970577862417 190 762456 SGTC_1307 1187-1599 12.2 µM 0.902704282690379 0.251319226128801 no 865 0.183341431440756 217 1538471 SGTC_1165 k072-0275 30.3 µM 0.902521792026894 0.251364628834709 no 866 0.183389875287673 210 6153523 YGL055W OLE1 SGTC_1212 0520-0165 585 µM 0.902049110901408 0.25148224954005 no 867 0.18351538999668 205 5403258 SGTC_3323 9138564 53.9225 µM 0.901729405929154 0.251561820554302 no 868 0.183600314100178 206 43912313 YNL103W MET4 SGTC_1525 8-methoxypsoralen 92.5 µM 0.901087430024409 0.251721641384567 no 869 0.183770917858871 211 4114 Related to psoralen; DNA damaging agent. SGTC_2170 morpholine 200 µM 0.900781755253923 0.251797758400173 no 870 0.183852184985733 191 121171 Reacts with secondary amines. SGTC_704 1310-0270 142 µM 0.900307390060987 0.251915905594811 no 871 0.183978344699726 214 5718033 SGTC_306 1672-3436 11.6 µM 0.899801767077735 0.252041870180323 no 872 0.184112876908626 214 6797378 SGTC_1157 4092-0394 27.6 µM 0.899575402737353 0.252098274527804 no 873 0.184173126001623 199 3659885 SGTC_1441 4106-0040 13 µM 0.899424734920548 0.252135820880366 no 874 0.184213234522583 196 2904180 SGTC_758 0868-0029 16 µM 0.898402353852772 0.252390675679398 no 875 0.184485541015554 193 762687 SGTC_1990 st072050 59.8 µM 0.897721904531473 0.252560370414913 no 876 0.184666914257039 214 17233948 SGTC_2258 7960471 200 µM 0.897503264915922 0.252614908895809 no 877 0.18472521600491 195 2974708 SGTC_341 1486-1430 230 µM 0.897231299721565 0.252682757813455 no 878 0.184797753350635 241 2054753 YPL210C SRP72 SGTC_2069 5228469 200 µM 0.89699725492718 0.252741154165901 no 879 0.184860190908245 217 2835210 SGTC_254 nsc-64875 3.808 µM 0.896686320617661 0.252818746157732 no 880 0.184943161027692 185 56993 SGTC_2405 ticlatone 3.52 µM 0.895130295724765 0.253207232166269 no 881 0.185358720318322 175 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_90 0870-0863 4.608 µM 0.894750342796637 0.253302141034613 no 882 0.185460280317605 238 1738164 SGTC_2654 protoveratrine a 100 µM 0.894655006706312 0.253325958078394 no 883 0.185485768718194 235 5702278 A heart drug and vasodilator. SGTC_2874 9043904 71.43 µM 0.894134954632602 0.253455899202033 no 884 0.185624844534034 208 4463428 SGTC_520 3584-0023 682 µM 0.89358953773064 0.253592215646688 no 885 0.185770773076494 212 1340790 SGTC_2218 6965428 192.983 µM 0.891812946735278 0.254036507223526 no 886 0.186246600542429 199 675684 SGTC_2655 perillic acid 100 µM 0.889704392954076 0.254564345854019 no 887 0.186812317288498 214 5702197 An apoptosis inducer. SGTC_2481 5478948 45.16 µM 0.887668941141421 0.255074429183415 no 888 0.187359428738071 208 77792 SGTC_100 0086-0128 49.5915 µM 0.886976235851189 0.255248142678487 no 889 0.187545847474894 235 93297 SGTC_1102 cgs 12066b 26.1 µM 0.882286623707497 0.256425807188756 no 890 0.18881091406949 192 6438352 A 5-HT1B full agonist. SGTC_429 1112-0049 25.5 µM 0.881607572274901 0.256596566257856 no 891 0.188994529403442 201 2836170 SGTC_1145 3546-0597 10.2 µM 0.880186035595235 0.256954227571973 no 892 0.189379268561291 220 875334 SGTC_1992 st073643 23.3 µM 0.879667902673687 0.25708465526183 no 893 0.189519621121383 216 3161292 SGTC_616 4092-0450 108 µM 0.878297487215694 0.257429790784294 no 894 0.189891149550653 235 787165 SGTC_2484 5809818 12.04 µM 0.876774309703893 0.257813681316123 no 895 0.190304617796604 197 2870548 SGTC_342 k048-0088 23.3 µM 0.873085019966 0.25874473273851 no 896 0.191308369146541 235 6820570 SGTC_924 2046-0044 21.3 µM 0.871373311308131 0.259177300134339 no 897 0.191775176636046 206 3623589 SGTC_26 0302-0163 425.158 µM 0.868126837788248 0.25999874495862 no 898 0.192662450226239 254 3100915 SGTC_1721 st082152 9.2685 µM 0.867939035164074 0.260046305103265 no 899 0.192713854042548 214 5296051 SGTC_1742 st038235 28.8875 µM 0.864458550199379 0.26092853300385 no 900 0.193668020449753 233 564103 YBR002C RER2 SGTC_2956 9076196 2.52 µM 0.862696458767283 0.261375771381288 no 901 0.194152189961856 242 16423868 SGTC_1928 4'-methoxychalcone 40.3 µM 0.862327518658939 0.261469462301276 no 902 0.194253656829989 228 641818 SGTC_1574 spiramycin 23.7 µM 0.86192575957217 0.261571507083962 no 903 0.194364186381143 241 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2646 retinol 96.75 µM 0.859948919758626 0.262073912022172 no 904 0.194908600207629 227 445354 A vitamin A analog and teratogen. SGTC_489 paxilline 115 µM 0.85897542189019 0.262321503749918 no 905 0.195177038074846 232 105008 A toxic potassium channel blocker. SGTC_323 4013-0906 34.3 µM 0.858821846299383 0.262360573885384 no 906 0.195219406395508 195 2910086 SGTC_2665 lovastatin 100 µM 0.858796021069186 0.262367144201575 no 907 0.19522653158986 231 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2940 9060638 45.86 µM 0.856786125602099 0.262878749334371 no 908 0.195781547429291 204 4027022 SGTC_553 k007-0256 45.7 µM 0.856077965434871 0.263059128105912 no 909 0.195977327869817 215 6287000 SGTC_1512 0259-0544 12.2 µM 0.855278185594641 0.263262919780283 no 910 0.196198580564967 211 18476 SGTC_3067 9117431 49.47 µM 0.85351347059801 0.263712871380508 no 911 0.196687310373292 250 17150885 SGTC_1353 1498-1206 8.11 µM 0.852008999014755 0.264096777894375 no 912 0.197104548700799 220 6756808 SGTC_399 oxolinic acid 75 µM 0.85073024580042 0.264423309987962 no 913 0.197459608833132 225 4628 A DNA gyrase inhibitor. SGTC_2295 7971645 200 µM 0.85053027644091 0.264474391121598 no 914 0.197515167509723 200 2978226 YKL099C UTP11 SGTC_811 0416-0114 265 µM 0.84835669926544 0.265029943863251 no 915 0.198119674872372 220 6612453 SGTC_2349 9023730 187.07 µM 0.84808331239184 0.265099861791501 no 916 0.198195787241404 217 4126287 SGTC_642 0335-0876 158 µM 0.846505757488248 0.265503499975876 no 917 0.198635331678831 246 6812350 SGTC_900 1112-0045 141 µM 0.844402397285162 0.26604215692323 no 918 0.199222291610132 210 56211 YIL048W NEO1 SGTC_333 3486-0131 40.1 µM 0.839051592675186 0.267414953951167 no 919 0.200720179280679 221 6744690 SGTC_2001 4023502 57.655 µM 0.837461795797164 0.267823518040497 no 920 0.201166521439506 205 108941 YCR052W RSC6 SGTC_1611 st001856 99.4 µM 0.836764723613049 0.268002758696359 no 921 0.201362414935813 244 647478 SGTC_750 4073-0104 132 µM 0.836430558626207 0.268088705142209 no 922 0.201456363599531 199 22330957 SGTC_125 0133-0007 11.75 µM 0.835794160889687 0.26825242349894 no 923 0.20163535598442 232 26541 SGTC_2771 fluoxetine 41.05 µM 0.835385261514951 0.268357642636969 no 924 0.201750412733878 226 3386 A selective serotonin reuptake inhibitor. SGTC_1725 st036284 20.55 µM 0.834046276588516 0.26870233921865 no 925 0.202127453503896 211 707914 SGTC_1945 st075991 56.6 µM 0.830781250545337 0.269543790464399 no 926 0.203048608222233 205 1084980 SGTC_2212 7123476 200 µM 0.830290705546618 0.269670326032212 no 927 0.203187220889025 210 1085715 SGTC_971 1315-0384 26.7 µM 0.828611968239247 0.27010357958893 no 928 0.203662006737505 222 6769120 SGTC_2869 9037858 32.47 µM 0.826719663135343 0.270592368480806 no 929 0.204197986854474 237 27187042 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.826153271058256 0.270738755360093 no 930 0.204358576030087 210 688664 SGTC_1788 fluconazole 20 µM 0.824481215885974 0.271171136946357 no 931 0.204833092318193 236 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1901 st060216 58.6 µM 0.821056039023471 0.272057937019434 no 932 0.205807174416338 222 688792 SGTC_939 1165-0479 45.3 µM 0.820957214630287 0.272083544670204 no 933 0.205835319705556 236 1377347 SGTC_2892 9047358 58.44 µM 0.819974006861456 0.2723383814467 no 934 0.206115462654328 221 6466771 SGTC_3169 9102970 49.47 µM 0.817970316813181 0.272858082926317 no 935 0.206687068398044 233 17027839 SGTC_3325 9138760 55.175 µM 0.817848270252661 0.272889754296413 no 936 0.20672191571953 230 43844959 SGTC_1461 k072-0203 53.8 µM 0.816979192772258 0.273115334651445 no 937 0.20697015947138 234 5418714 SGTC_2300 7976697 71.57 µM 0.815529396565943 0.27349185365153 no 938 0.207384672405797 213 2236109 SGTC_3133 9127736 49.47 µM 0.815505838933085 0.273497973802102 no 939 0.20739141184593 213 27243420 SGTC_3229 9132204 49.47 µM 0.812143371218431 0.274372220187418 no 940 0.208354684485043 223 17682924 SGTC_2557 derrustone 83.84 µM 0.812078666539368 0.274389057014718 no 941 0.208373246788559 259 629853 An antioxidant. SGTC_1073 triclabendazole 3.09 µM 0.811045470414397 0.274657974409342 no 942 0.2086697794197 228 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2783 7738165 71.43 µM 0.809775096464155 0.274988801847544 no 943 0.209034724039349 244 17201110 SGTC_556 4058-0063 51.5 µM 0.809063145035526 0.275174292166152 no 944 0.209239412986092 227 6615692 SGTC_343 4130-2827 29.8 µM 0.80869692828186 0.275269729493331 no 945 0.209344747737678 225 1118244 SGTC_1274 0865-0114 173 µM 0.806613849751052 0.275812896525832 no 946 0.20994449595635 226 870624 SGTC_1777 st045864 34.765 µM 0.806423907913131 0.275862450440909 no 947 0.209999233127504 282 4691462 SGTC_3236 9132701 49.47 µM 0.805450166800459 0.276116558372628 no 948 0.21027997613003 240 24282524 SGTC_3312 9133330 71.43 µM 0.805224668912582 0.276175420787704 no 949 0.210345021698669 245 17617324 SGTC_246 cycloheximide 667 µM 0.804999963925931 0.276234082355066 no 950 0.210409850302069 237 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1987 st072290 61.9 µM 0.804218558124772 0.276438124033399 no 951 0.210635381394815 234 54697379 SGTC_3138 9097216 49.47 µM 0.803652417461555 0.276586001564217 no 952 0.210798870752354 252 25237486 SGTC_3272 9137413 49.47 µM 0.802162823262032 0.276975272882133 no 953 0.2112293891778 243 17614870 SGTC_592 k241-0073 46.5 µM 0.800893232875814 0.277307262824127 no 954 0.211596729030894 236 4230158 SGTC_53 0973-0023 39.979 µM 0.799504438526531 0.277670646582871 no 955 0.211998987011135 243 674768 SGTC_3355 9151058 44.0485 µM 0.797894420821209 0.278092205256385 no 956 0.21246588065725 231 17015728 SGTC_2030 5175110 200 µM 0.797373961852674 0.278228546272461 no 957 0.212616938430081 245 2831986 SGTC_731 3966-0296 387 µM 0.797224574267483 0.278267686318433 no 958 0.212660308196693 215 660956 SGTC_3273 9137859 49.47 µM 0.79649683619529 0.278458394503639 no 959 0.21287165685092 269 2377234 SGTC_671 0560-0003 407 µM 0.793349064087073 0.279284019982375 no 960 0.213787239173392 218 3238678 SGTC_3174 9107204 49.47 µM 0.79000359410696 0.28016280130256 no 961 0.214762834672311 246 3938802 SGTC_215 1287-0124 461.5 µM 0.789552575655173 0.280281376333204 no 962 0.214894556851786 238 5560863 SGTC_2681 menadione 3.18 µM 0.788991876723901 0.28042882080097 no 963 0.215058377174728 265 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1410 3909-8106 77.9 µM 0.78890031771116 0.280452901227482 no 964 0.215085135006496 249 1039210 SGTC_2858 9025781 8.96 µM 0.787981782653788 0.280694535399097 no 965 0.215353680914989 231 4894980 YPL153C RAD53 SGTC_909 3448-9333 149 µM 0.787707364428857 0.280766744685548 no 966 0.215433948449812 225 3344074 SGTC_3104 9120930 49.47 µM 0.787443806426086 0.280836104713512 no 967 0.215511055697697 239 17014836 SGTC_1618 st003135 44.5 µM 0.786861916755397 0.280989268773608 no 968 0.215681351597008 263 1270615 SGTC_604 1000-0114 314 µM 0.78668993675825 0.281034544798006 no 969 0.215731698215721 242 1572745 SGTC_482 fipronil 114 µM 0.786598796359106 0.281058540150626 no 970 0.215758382050745 238 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1862 st057513 3.81 µM 0.786492502513825 0.281086526337605 no 971 0.215789504886595 251 5393163 SGTC_1651 st011928 86.1 µM 0.784312881799942 0.281660696956454 no 972 0.216428271309835 228 720198 SGTC_2022 5136654 200 µM 0.782167317990126 0.282226447826919 no 973 0.217058124342593 254 1713771 SGTC_661 1304-0007 33.6 µM 0.78124763243202 0.28246912155138 no 974 0.217328431786314 242 3117130 SGTC_152 4469-0003 551.229 µM 0.780963287774978 0.282544170733859 no 975 0.21741204367165 247 697280 SGTC_1322 1348-1070 12 µM 0.780902564926724 0.28256019900518 no 976 0.217429901703829 253 6758089 SGTC_1943 st076331 65.2 µM 0.780598850262901 0.282640373429256 no 977 0.217519234107613 235 24208415 SGTC_2304 7443016 91.4 µM 0.777892055577806 0.283355394070013 no 978 0.218316326063578 242 939854 SGTC_172 1112-0046 2.638 µM 0.777402859901639 0.283484711351194 no 979 0.218460562841998 245 2802135 YIL048W NEO1 SGTC_1914 st062367 72.6 µM 0.775754783344775 0.283920583056012 no 980 0.2189468932538 248 978205 SGTC_1839 st053978 48 µM 0.771758663891187 0.284978778300349 no 981 0.220128689140917 237 3788398 SGTC_2951 9072950 58.06 µM 0.771500528573114 0.285047198628093 no 982 0.22020515461233 258 16488155 SGTC_948 3448-0295 75.3 µM 0.769427436302292 0.285596968107643 no 983 0.220819803162991 240 678569 SGTC_140 0062-0056 502.533 µM 0.76767882400196 0.28606107975507 no 984 0.221339009950762 238 3758964 SGTC_347 4534-1311 26.2 µM 0.765431197290914 0.286658164214458 no 985 0.222007410909592 253 2862016 SGTC_1259 0671-0132 43 µM 0.762638854884917 0.287400775130551 no 986 0.222839402776675 238 X1259 SGTC_1268 0828-0275 2.46 µM 0.761855772948479 0.287609195515429 no 987 0.223073044374284 258 745337 SGTC_1343 1487-0095 224 µM 0.761231581041727 0.287775377837045 no 988 0.223259379152351 272 4560101 YGL055W OLE1 SGTC_2703 st077852 53.4 µM 0.760785786035848 0.287894092251941 no 989 0.223392512810673 262 6281836 SGTC_361 000s-0510 1.45 µM 0.760532103176581 0.287961657867655 no 990 0.223468293640195 253 660 SGTC_1290 0986-0249 10.2 µM 0.759686780138486 0.288186854300736 no 991 0.223720916352624 264 53329 SGTC_3306 9127676 59.7925 µM 0.757952978956544 0.288649003581915 no 992 0.224239566258815 249 41905287 SGTC_1781 st038725 66.3 µM 0.757577509578488 0.28874913189968 no 993 0.224351974167807 263 4270275 YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM 0.756937305400266 0.288919896090419 no 994 0.224543712046256 236 292895 SGTC_3223 9129970 49.47 µM 0.756128519549558 0.289135694652691 no 995 0.2247860721385 266 17248386 SGTC_2544 sphondin 68.51 µM 0.755032734945056 0.289428190474057 no 996 0.225114670533964 242 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_565 1418-0001 44.5 µM 0.753951981952596 0.289716810011835 no 997 0.225439027734326 253 2862145 SGTC_205 1486-1330 71.903 µM 0.753068001432331 0.289952981021643 no 998 0.225704525871783 249 4118834 SGTC_3233 9132340 49.47 µM 0.752651670615257 0.29006424241475 no 999 0.22582962953194 288 17682950 SGTC_2370 9071495 200 µM 0.752371239193998 0.290139196956896 no 1000 0.225913918747547 260 21791103 SGTC_2517 totarol 10 µM 0.752154966787027 0.290197009085661 no 1001 0.225978935848988 242 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_381 3461-2219 42.7 µM 0.751323080549433 0.290419432237679 no 1002 0.226229121031126 258 2883159 SGTC_1477 0139-0234 16 µM 0.750624288721687 0.290606331315602 no 1003 0.226439399691218 244 620880 SGTC_3239 9133757 49.47 µM 0.750115773195816 0.290742374399573 no 1004 0.226592490247605 280 17036923 SGTC_2283 7944793 200 µM 0.749469196118926 0.290915396065001 no 1005 0.22678722910867 250 2970533 SGTC_2134 5324836 1.464 µM 0.749074481582963 0.291021043883019 no 1006 0.226906157330065 269 699272 SGTC_2649 anisomycin 9.56 µM 0.748401648494192 0.291201173179389 no 1007 0.22710896425173 249 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1384 3089-0840 101 µM 0.748143502911316 0.291270297123638 no 1008 0.227186802212692 228 1069836 SGTC_963 1269-2853 151 µM 0.746758627491904 0.291641257523275 no 1009 0.227604636682473 234 3668223 SGTC_1807 st050092 58.9 µM 0.744590237538259 0.29222253645125 no 1010 0.228259735712093 251 5008496 SGTC_1190 1486-1332 13 µM 0.743465651685453 0.292524215575983 no 1011 0.228599904785287 258 4150046 SGTC_1868 st057644 42.7 µM 0.742573141507455 0.29276374151759 no 1012 0.228870077234952 251 688665 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.739533833115746 0.293580093204088 no 1013 0.229791451593697 256 16623 A steroid. SGTC_546 peri-Naphthalide 147 µM 0.739409054876127 0.293613630882715 no 1014 0.229829322778859 245 223824 A penicillin ester. SGTC_3292 9120825 59.784 µM 0.734996526829951 0.294800761197966 no 1015 0.231170804677363 258 24824900 SGTC_2084 5306078 60.6385 µM 0.734393783869573 0.294963092574175 no 1016 0.231354387113892 281 679340 SGTC_3044 9093193 49.47 µM 0.734197615052966 0.295015933850942 no 1017 0.23141415341507 267 25236277 SGTC_2050 5263056 171 µM 0.734048363622132 0.29505614008394 no 1018 0.231459631270957 246 763468 YGL055W OLE1 SGTC_409 arachidonic acid 100 µM 0.733185813959975 0.295288548237186 no 1019 0.231722553205835 256 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.732523792266717 0.295466982616257 no 1020 0.231924463134808 237 6857784 SGTC_2569 tetrandrine 100 µM 0.732226933981078 0.295547010784111 no 1021 0.232015033720676 244 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2502 avocadyne acetate 18.59 µM 0.730207040282474 0.296091805715444 no 1022 0.232631819897642 247 3952079 SGTC_3327 9140648 26.9345 µM 0.729898120221728 0.296175166597789 no 1023 0.232726230711513 280 8029710 SGTC_3267 9137951 49.47 µM 0.728834523555792 0.296462256356925 no 1024 0.23305144533803 284 16643986 SGTC_3245 9134821 49.47 µM 0.727700960572976 0.296768371991884 no 1025 0.233398331104638 280 17014901 SGTC_2813 7971799 71.43 µM 0.726632842376531 0.297056946779662 no 1026 0.233725451824717 246 2234054 SGTC_2954 9074818 52.69 µM 0.72651928373653 0.297087634600606 no 1027 0.233760245110619 270 16648742 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.724311877102655 0.297684446744475 no 1028 0.234437143468162 252 4174840 SGTC_3221 9128209 49.47 µM 0.724101909150299 0.297741243844183 no 1029 0.234501586304025 277 16460723 SGTC_2768 sulfasalazine 50.2 µM 0.722241930167656 0.298244590684298 no 1030 0.235072874070681 276 5384001 An antioxidant and salicylic acid derivative. SGTC_1233 0325-0408 14.2 µM 0.719917460677326 0.298874181910068 no 1031 0.235787908368793 257 12874 SGTC_375 3970-0961 9.27 µM 0.719802012603595 0.298905467185281 no 1032 0.235823452792887 255 2898222 SGTC_756 0508-1999 28.3 µM 0.719647100104596 0.298947449262956 no 1033 0.235871152257927 282 6753853 SGTC_1037 k284-1091 78.7 µM 0.719221528128553 0.29906279522271 no 1034 0.236002218477327 254 3334711 SGTC_744 1594-0068 283 µM 0.718727432884918 0.299196738899221 no 1035 0.236154438594037 274 668392 SGTC_1965 Pectolinarigenin 58.4 µM 0.718156603631104 0.299351518189306 no 1036 0.23633036612041 275 5320438 An anti-inflammatory. SGTC_65 0798-0905 34.986 µM 0.717232664391772 0.299602119522822 no 1037 0.236615273734573 284 3602145 SGTC_1915 st067105 30.6 µM 0.716311022220333 0.299852192483668 no 1038 0.236899661181949 268 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2403 6032726 181.2 µM 0.715752238875045 0.300003855465611 no 1039 0.237072174188686 257 2881040 SGTC_1779 st039427 55 µM 0.713224092145914 0.300690469360619 no 1040 0.237853550184176 279 1124498 SGTC_52 0329-0193 875 nM 0.712250275499345 0.300955135192879 no 1041 0.238154904692065 282 3739292 SGTC_1257 0669-0121 16 µM 0.710472657245513 0.301438530487591 no 1042 0.238705540443007 276 4307855 SGTC_177 1327-0068 8.361 µM 0.70525017233394 0.302860720185898 no 1043 0.240327281557029 272 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1009 4106-0057 9.87 µM 0.705228928705236 0.302866511392143 no 1044 0.240333890588245 266 2928005 SGTC_3334 9142812 21.919 µM 0.703737532619761 0.30327320336653 no 1045 0.240798121015466 257 45283678 SGTC_3028 9087778 49.47 µM 0.703217507405281 0.303415067529543 no 1046 0.240960105158884 258 17217395 SGTC_2792 7535235 81.82 µM 0.702583390270649 0.303588096358527 no 1047 0.241157708289847 264 1281891 SGTC_455 paf C-16 10 µM 0.702467027488689 0.303619852556483 no 1048 0.241193978740331 255 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_979 1426-2828 121 µM 0.699392674808117 0.304459400966381 no 1049 0.242153332207657 256 747872 SGTC_151 3013-0144 2.285 µM 0.699136877126442 0.304529301080275 no 1050 0.242233247136388 281 906558 YHR107C CDC12 SGTC_1879 gemcitabine 100 µM 0.698992121998063 0.304568860505031 no 1051 0.24227847708395 288 60750 A nucleoside analog which inhibits DNA replication. SGTC_371 0195-0006 7.36 µM 0.697739314167652 0.304911329726009 no 1052 0.242670118501789 260 3928593 SGTC_1689 st020265 53.493 µM 0.694331649833527 0.305843717737686 no 1053 0.243737123473536 274 5758320 YPR016C TIF6 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.693334549572324 0.306116777828844 no 1054 0.244049812943079 252 6708561 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.692120354295261 0.306449435804911 no 1055 0.244430875131668 273 16486 A toxic proline analog. SGTC_109 0132-0036 33.701 µM 0.691817058345674 0.306532555937274 no 1056 0.244526111337196 249 67274 A color developer. SGTC_1704 st028805 70.8 µM 0.690664904169792 0.306848401616411 no 1057 0.244888074720769 282 2876101 SGTC_3016 9080866 49.47 µM 0.689485901084992 0.307171756018303 no 1058 0.245258771315028 268 17066299 SGTC_1076 itraconazole 331 nM 0.686268698517022 0.308054871314209 no 1059 0.246271841861573 265 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1062 mesoridazine 14.2 µM 0.684565233426078 0.308522919737199 no 1060 0.246809156014605 265 4078 A neuroleptic. SGTC_1695 st026914 34.495 µM 0.683606007548479 0.308786616158646 no 1061 0.247111995059675 272 3289191 SGTC_2423 st077119 87.2 µM 0.68210825549347 0.309198553524969 no 1062 0.247585250421067 258 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_232 clozapine 119 µM 0.681993149358683 0.309230221918005 no 1063 0.247621641348604 268 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM 0.680103773938327 0.309750235766424 no 1064 0.248219377519918 277 3246252 SGTC_99 0109-0120 622.8 µM 0.679778664630266 0.309839754228473 no 1065 0.248322308934837 287 759414 SGTC_2864 9034755 47.6 µM 0.677313558238879 0.310518884972376 no 1066 0.249103515157006 265 4930451 SGTC_2165 5727197 32.143 µM 0.675227139418224 0.311094193426703 no 1067 0.24976573326394 282 1361712 SGTC_1729 st035615 45.989 µM 0.671294079496418 0.312179949345333 no 1068 0.251016602776166 282 17385451 SGTC_2417 cerulenin 830 nM 0.671182408510857 0.312210800995939 no 1069 0.251052166922165 282 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_378 3970-0959 8.33 µM 0.670655760703893 0.31235631718244 no 1070 0.251219925729723 290 6615653 SGTC_179 1273-0063 6.77 µM 0.670636227981357 0.312361714762739 no 1071 0.251226148838466 293 3108139 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.670299892654789 0.312454662393274 no 1072 0.251333317772511 265 3256 An antibiotic and ribosome inhibitor. SGTC_448 monastrol 171 µM 0.668848143057884 0.312855996132257 no 1073 0.251796176305106 294 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1245 0418-0076 17.2 µM 0.668227723386733 0.313027577820805 no 1074 0.251994120690987 299 6790114 SGTC_1430 4049-0248 69.1 µM 0.66657821507784 0.31348395855744 no 1075 0.252520794063625 287 22774488 SGTC_543 3844-1095 191 µM 0.664552499328331 0.31404481801612 no 1076 0.253168379752493 293 4230703 SGTC_1708 st033234 31.827 µM 0.662243467845113 0.314684643195799 no 1077 0.253907600320306 260 674664 SGTC_96 0929-0093 37.281 µM 0.661414777938031 0.314914406375961 no 1078 0.254173175665197 284 6991579 SGTC_2290 7904846 200 µM 0.660616955523487 0.315135678914115 no 1079 0.254428996285862 281 2962154 SGTC_2976 9009005 19.48 µM 0.657815897100997 0.315913065112237 no 1080 0.255328219024414 262 2993148 SGTC_1223 0764-0573 147 µM 0.657507360779424 0.315998744010523 no 1081 0.255427369795106 273 1609797 SGTC_1733 st037357 54.9 µM 0.657352641181028 0.316041712542884 no 1082 0.255477097827151 284 1272339 YGL099W LSG1 SGTC_2587 piperic acid 92.2 µM 0.65730095074547 0.316056068499507 no 1083 0.255493712645585 272 5370536 SGTC_1401 3807-4679 7.6 µM 0.652733354087986 0.317325717684103 no 1084 0.25696409784451 297 3291456 SGTC_802 4112-3352 742 µM 0.652169459342955 0.317482612385657 no 1085 0.257145929747787 260 704594 SGTC_1449 4112-4002 201 µM 0.651197606445049 0.317753091876555 no 1086 0.257459467628388 283 2059539 SGTC_492 tmb-8 126 µM 0.650026268562917 0.31807921995636 no 1087 0.257837626858545 277 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2755 lomerizine 42.69 µM 0.647953253512566 0.318656741958485 no 1088 0.258507592802233 284 3949 A calcium channel blocker. SGTC_1966 st070145 16.1 µM 0.647742140330409 0.318715580807493 no 1089 0.258575871822189 295 3748532 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.644887400735531 0.319511666706972 no 1090 0.259500078556918 276 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.644781759796939 0.319541142224015 no 1091 0.259534311951615 290 551469 SGTC_2199 6590217 200 µM 0.644643412917943 0.319579744947432 no 1092 0.259579147371705 275 703109 SGTC_1563 conessine 56.1 µM 0.644283937256571 0.319680058043895 no 1093 0.259695664842181 294 441082 An anti-amoebic, histamine inhibitor. SGTC_1042 0350-0096 82 µM 0.642443697695411 0.320193790633768 no 1094 0.260292567424683 293 3122515 SGTC_46 0329-0187a 2.197 µM 0.641043817020119 0.320584820957657 no 1095 0.260747107540685 294 46494817 SGTC_1314 1222-0010 41.1 µM 0.638239563696707 0.32136873526182 no 1096 0.26165887330055 296 3526027 SGTC_1529 apigenin 74 µM 0.634348508838345 0.322457777976053 no 1097 0.262926702737791 303 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_912 3474-0017 2.18 µM 0.633368232179124 0.322732382309589 no 1098 0.263246602614984 306 3360550 SGTC_644 1498-1197 63.3 µM 0.633169989918736 0.3227879275592 no 1099 0.263311320422932 292 6741615 SGTC_50 0929-0078 56.389 µM 0.630396944300443 0.323565317728275 no 1100 0.26421745478358 271 1377751 SGTC_2310 7668677 200 µM 0.628174368280877 0.324188946924197 no 1101 0.264944859702747 317 2197143 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.627554264892333 0.324363028925533 no 1102 0.26514798862794 313 688801 SGTC_1075 aripiprazole 15.2 µM 0.626834270718992 0.324565201495868 no 1103 0.265383938233934 281 60795 An atypical antipschotic. YIL048W NEO1 SGTC_233 rapamycin 362 pM 0.626705268608836 0.324601430431027 no 1104 0.265426224825702 285 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_286 k060-0067 22.9 µM 0.626316407339481 0.324710648218185 no 1105 0.265553713329454 281 5985051 SGTC_75 0159-0059 199.013 µM 0.625586777453423 0.324915616884515 no 1106 0.26579300690686 342 5377270 SGTC_787 4152-0075 138 µM 0.625013186464519 0.325076788103967 no 1107 0.265981201783564 287 9566539 SGTC_317 4495-0002 170 µM 0.623523415522842 0.325495546224914 no 1108 0.266470309924067 286 15991618 SGTC_1765 st044815 90.4 µM 0.622611176085808 0.325752075456425 no 1109 0.266770032564241 305 645695 SGTC_732 3970-1727 52.7 µM 0.62089388451106 0.326235215811773 no 1110 0.267334722587857 304 1275699 SGTC_1490 4089-0339 670 nM 0.620131476701449 0.326449804102843 no 1111 0.267585615211725 305 742542 SGTC_1349 flufenamic acid 69 µM 0.619372977142397 0.326663349382869 no 1112 0.267835339448984 299 3371 A non-steroidal anti-inflammatory. SGTC_782 0083-0095 30.5 µM 0.619004667659056 0.326767062422376 no 1113 0.267956641974543 296 3591729 An indicator and reagent. SGTC_2543 pimpinellin 60.67 µM 0.618662420121184 0.326863448623431 no 1114 0.268069385804814 295 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1763 st044482 94.5 µM 0.617671625281647 0.327142548475901 no 1115 0.26839590988444 302 88505 SGTC_2291 7917025 104.35 µM 0.616210499898019 0.327554313498255 no 1116 0.268877799706426 292 2964612 SGTC_249 wiskostatin 11.211 µM 0.616089230063292 0.327588498426062 no 1117 0.268917814900754 287 2775510 A n-wasp and actin depolymerizer. SGTC_1734 st037168 69.4 µM 0.615646564200717 0.327713294407206 no 1118 0.269063905950139 300 708907 SGTC_2983 9022671 12.99 µM 0.614655510646143 0.327992761141069 no 1119 0.269391123295804 308 6405161 SGTC_598 3937-0236 20.2 µM 0.614524163522708 0.328029806888735 no 1120 0.269434505301869 314 1379313 SGTC_803 4488-1585 147 µM 0.614197877924585 0.3281218413027 no 1121 0.269542287746922 285 747204 SGTC_3171 9103192 49.47 µM 0.612247529535124 0.328672187762782 no 1122 0.270186999693493 303 13018434 SGTC_3279 9140807 49.47 µM 0.611950108591853 0.328756146271428 no 1123 0.270285383619301 298 45595718 SGTC_3335 9143315 29.6265 µM 0.611419644111984 0.328905911741427 no 1124 0.270460900507151 286 4899691 SGTC_2516 gossypol 71.55 µM 0.611326886890115 0.328932102611563 no 1125 0.270491597306517 308 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1004 4084-0029 199 µM 0.608434079704115 0.329749334832617 no 1126 0.271449807152742 302 716894 YLR208W SEC13 SGTC_321 4534-3890 65.3 µM 0.605831957631031 0.330485142266845 no 1127 0.272313173072801 318 699746 SGTC_497 capsazepine 133 µM 0.604421770328674 0.330884178032452 no 1128 0.272781632720265 287 2733484 A calcium channel blocker. SGTC_1842 st055362 61.2 µM 0.603398220699711 0.331173928712468 no 1129 0.273121902812477 289 676032 SGTC_620 0109-0052 432 µM 0.602853287221743 0.331328232004724 no 1130 0.273303146932112 309 493037 SGTC_407 eburnamonine 100 µM 0.602336056568078 0.331474717462752 no 1131 0.273475232218332 290 3195 SGTC_1398 3558-0053 112 µM 0.601198941974667 0.331796851550954 no 1132 0.273853744547184 288 4532369 SGTC_2761 levamisole 97.89 µM 0.598066247132136 0.332684958012747 no 1133 0.274897865342269 315 26879 An alkaline phosphatase inhibitor. SGTC_2693 st077581 40.7 µM 0.595381479935712 0.333446826890628 no 1134 0.275794251129749 309 25238761 SGTC_3237 9133362 49.47 µM 0.595013504030545 0.333551302769037 no 1135 0.275917222171761 318 43845137 SGTC_2125 5246583 200 µM 0.594693483402018 0.333642173661243 no 1136 0.276024189300841 311 835267 SGTC_1836 st055642 81 µM 0.592667180540712 0.334217775270306 no 1137 0.27670195479459 312 8571 SGTC_1932 st074806 40.9 µM 0.592580476330942 0.334242413608963 no 1138 0.276730974131674 312 17251235 SGTC_822 1487-0950 154 µM 0.590751021741467 0.334762447725691 no 1139 0.277343628144145 281 1958375 SGTC_2254 7938975 95.19 µM 0.588007527773649 0.335542897411751 no 1140 0.278263620034472 314 2969277 SGTC_2386 9075165 157.42 µM 0.58703701823131 0.335819151278005 no 1141 0.278589422565702 298 16452277 SGTC_2148 5546263 113.568 µM 0.586549129777236 0.335958061412013 no 1142 0.278753278109055 307 792097 SGTC_2369 9071472 200 µM 0.586410682399959 0.335997483815795 no 1143 0.278799783694949 310 17296037 SGTC_2726 cimetidine 79.27 µM 0.585911665504477 0.336139592090414 no 1144 0.278967438805 309 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_637 1181-0519 7.26 µM 0.585016535301392 0.336394562795281 no 1145 0.279268299251523 304 6252091 YGR060W ERG25 SGTC_2439 5492030 7.2 µM 0.58396684980524 0.336693653211896 no 1146 0.279621307716958 302 5722370 SGTC_1905 st060207 84.5 µM 0.583013104350537 0.336965496709519 no 1147 0.279942239305946 297 1948547 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.582464900418893 0.337121788358965 no 1148 0.280126788570028 331 7104 SGTC_127 0180-0333 59.125 µM 0.580591820352106 0.337656011100104 no 1149 0.280757793201555 280 771601 SGTC_2661 dactinomycin 12.96 µM 0.579405745218869 0.337994461903686 no 1150 0.281157714215131 305 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2073 5212005 126 µM 0.577592365820269 0.338512169416805 no 1151 0.281769681149054 330 691789 SGTC_2164 5685496 200 µM 0.577165860394741 0.33863397821172 no 1152 0.281913708501563 307 759046 SGTC_1169 aniline yellow 25.8 µM 0.576399114545114 0.338853001197466 no 1153 0.282172721389688 317 6051 A DNA damaging agent. SGTC_793 0488-0545 106 µM 0.57338062448794 0.33971576981664 no 1154 0.283193503141284 320 292548 SGTC_3081 9117243 49.47 µM 0.57044747422172 0.340554951258299 no 1155 0.284187119014248 318 45595589 SGTC_3246 9135460 32.98 µM 0.570122679968808 0.340647924339943 no 1156 0.284297246740854 326 41446951 SGTC_2902 5787006 60.46 µM 0.570025600343729 0.340675715479646 no 1157 0.284330167410682 306 591003 SGTC_753 1322-0200 289 µM 0.566695328500115 0.341629600585537 no 1158 0.285460597624635 297 5403907 SGTC_2413 inermin 26.06 µM 0.566399105492137 0.341714496439787 no 1159 0.28556125135013 343 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_614 0462-0418 107 µM 0.566228479907975 0.341763400410514 no 1160 0.285619235946745 309 5188303 SGTC_579 4491-1009 110 µM 0.56509670912156 0.342087850879059 no 1161 0.286003993382159 333 1271041 SGTC_587 k089-0003 57 µM 0.561422921368922 0.343141836920264 no 1162 0.287254630965733 315 9659696 SGTC_442 cape 100 µM 0.561310552292939 0.343174094176724 no 1163 0.287292924609937 306 5281787 SGTC_2941 9056145 11.23 µM 0.558859619281857 0.343877955795499 no 1164 0.288128765017863 319 2119517 SGTC_2995 9067767 71.4286 µM 0.555559256345152 0.344826612749778 no 1165 0.289256095483827 314 11673567 SGTC_3146 9095609 49.47 µM 0.555354424430079 0.34488552191513 no 1166 0.289326129777463 316 17173999 SGTC_2819 7996655 46.38 µM 0.554546613386395 0.345117883071868 no 1167 0.289602406942537 310 6456960 SGTC_43 0570-0105 72.5 µM 0.552231357971382 0.345784173319199 no 1168 0.290394926289481 313 1114046 YDL195W SEC31 SGTC_2 0422-0095 29 µM 0.550831474903681 0.346187267306239 no 1169 0.290874602803396 286 6790840 SGTC_2519 cryptotanshinone 88.04 µM 0.549490827953128 0.346573467779493 no 1170 0.29133432865804 307 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_382 3229-0966 23.2 µM 0.545796888031584 0.347638406173902 no 1171 0.292602781329865 337 5722370 SGTC_3089 9117425 49.47 µM 0.545138671997191 0.347828292057519 no 1172 0.29282907353377 343 9401657 SGTC_2650 prasterone 100 µM 0.544037394405511 0.348146080191867 no 1173 0.29320787021504 299 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1530 rhein 70.4 µM 0.543921248803678 0.348179601754385 no 1174 0.293247833026472 322 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1086 cerivastatin 2.18 µM 0.543386449994099 0.348333968934157 no 1175 0.293431876559786 296 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1665 st014639 11.4 µM 0.543070621808094 0.348425143068005 no 1176 0.293540589539252 319 981133 YIL048W NEO1 SGTC_3295 9122362 53.5725 µM 0.542745161752336 0.348519106919079 no 1177 0.293652637467635 334 4730473 SGTC_300 r073-0011 5.04 µM 0.541029127432468 0.349014698252219 no 1178 0.294243753198984 317 2735780 SGTC_1613 st002381 52.1 µM 0.538426981748983 0.349766690220183 no 1179 0.295141151434158 309 551167 SGTC_972 1319-0219 195 µM 0.537738532505289 0.349965743386951 no 1180 0.295378786585839 330 23903702 SGTC_1630 st005209 31.3 µM 0.537639500087744 0.349994380287916 no 1181 0.29541297729598 318 3367314 SGTC_1253 0550-0034 176 µM 0.535709405832927 0.350552669903657 no 1182 0.296079701010805 309 5969915 SGTC_1952 st077036 64.1 µM 0.533737567606995 0.351123367711959 no 1183 0.296761556841636 323 2937007 SGTC_2149 5554786 194.827 µM 0.531506133607542 0.351769603986114 no 1184 0.29753404602548 324 745063 YPR165W RHO1 SGTC_3317 9138495 8.753 µM 0.531378800007022 0.35180649347932 no 1185 0.297578154694379 324 17020139 SGTC_2807 7945238 51.95 µM 0.531102744085843 0.351886473728149 no 1186 0.297673791385402 346 17148797 SGTC_2603 homopterocarpin 100 µM 0.530527018214143 0.352053296881158 no 1187 0.297873290713436 327 101795 A weak amylase inhibitor. SGTC_2882 9058044 58.44 µM 0.529226493822574 0.352430243475291 no 1188 0.298324169964686 307 18076804 SGTC_831 k061-1017 217 µM 0.528874881279159 0.352532180472156 no 1189 0.298446123972498 345 1240153 SGTC_148 3253-0744 288.01 µM 0.528505758746031 0.352639205236028 no 1190 0.298574175583356 317 6893655 SGTC_3206 9114350 49.47 µM 0.528339503160737 0.352687413811223 no 1191 0.298631859160161 310 17087243 SGTC_3053 9095903 49.47 µM 0.526938297838118 0.353093810549262 no 1192 0.299118218675069 367 17174018 SGTC_2720 fluspirilene 36.88 µM 0.524227464233542 0.353880519085731 no 1193 0.300060170406273 328 3396 An atypical antipsychotic. SGTC_1748 st037455 53.6035 µM 0.520587121582849 0.354937961272902 no 1194 0.301327211313499 340 580690 SGTC_1555 citronellol 128 µM 0.520310260975562 0.355018429262048 no 1195 0.301423672643348 343 8842 A terpine precursor. SGTC_2294 7971431 200 µM 0.51919831111613 0.355341676390463 no 1196 0.301811228332969 375 5741572 SGTC_1617 st002906 78 µM 0.519038092330472 0.355388261053489 no 1197 0.301867088966613 349 5150859 SGTC_210 3551-0445 56.827 µM 0.517556064034605 0.355819272856069 no 1198 0.302384021499118 337 2865180 YOR207C RET1 SGTC_2116 5511452 16.8835 µM 0.516063943147901 0.356253406113829 no 1199 0.302904875049874 345 870744 SGTC_3109 9122853 49.47 µM 0.51575313369234 0.356343859741586 no 1200 0.303013419600675 380 1234709 SGTC_1700 st030840 7.9285 µM 0.515642874074448 0.356375950097975 no 1201 0.303051929949216 356 5499307 SGTC_1093 fluphenazine 7.97 µM 0.515360248539582 0.356458211095786 no 1202 0.303150652495971 347 6602611 An atypical antipsychotic. SGTC_2711 st079103 59.1 µM 0.514204437339178 0.356794691010907 no 1203 0.303554532861843 341 54693780 SGTC_859 0439-0102 54.6 µM 0.512808811803335 0.357201134235045 no 1204 0.304042532608563 340 610143 SGTC_2368 9071271 200 µM 0.512458197330881 0.357303267974204 no 1205 0.304165184741226 363 27209959 SGTC_328 k915-0120 63.5 µM 0.51207022804115 0.357416295059538 no 1206 0.304300930041353 312 6624543 SGTC_2158 5657123 3.6195 µM 0.509611445406345 0.358132902636124 no 1207 0.305161851899258 382 2858827 SGTC_441 propafenone 146 µM 0.50842795270721 0.358478007802577 no 1208 0.305576626879378 345 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1121 fusaric acid 630.51 nM 0.508177608311108 0.358551022776012 no 1209 0.305664396300466 304 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.508073664369212 0.358581340388991 no 1210 0.305700841777682 316 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2266 7929956 200 µM 0.506296344452127 0.359099873899207 no 1211 0.306324314427605 334 2967153 SGTC_1964 st076914 61 µM 0.505877386098783 0.35922214295631 no 1212 0.306471364186204 366 24208661 SGTC_845 0330-0138 4.51 µM 0.505508245143436 0.359329885224103 no 1213 0.306600954418708 356 9039800 SGTC_1058 3448-5425 97.3 µM 0.505169676486917 0.359428714099505 no 1214 0.30671983323552 340 7279705 SGTC_2859 9028643 45.46 µM 0.503769580565243 0.359837504719439 no 1215 0.307211653154712 310 17151580 SGTC_2463 5473429 200 µM 0.503671267081044 0.359866215663257 no 1216 0.307246201357304 351 5399405 SGTC_1778 st046819 58.9 µM 0.503344759021778 0.359961573002579 no 1217 0.307360951367306 353 671715 SGTC_2242 6630449 61.2675 µM 0.502965399218653 0.360072376746788 no 1218 0.30749429960686 344 691249 YDR170C SEC7 SGTC_1041 0206-0046 107 µM 0.50222986515231 0.360287245673289 no 1219 0.307752918653425 338 50494 SGTC_2682 pyrogallin 40.03 µM 0.501624141704034 0.360464226633815 no 1220 0.307965967107317 323 822798 An ATP competetive kinase inhibitor. SGTC_595 3909-8003 73.7 µM 0.500905749224804 0.360674166114746 no 1221 0.308218728068861 342 699517 SGTC_1638 st008370 60.6 µM 0.497984445192577 0.361528305653995 no 1222 0.309247502890128 311 24207134 SGTC_1020 4335-0961 93.3 µM 0.496925426930805 0.361838115317033 no 1223 0.309620820035746 366 669075 SGTC_3112 9123419 49.47 µM 0.495963183680782 0.362119692551782 no 1224 0.309960193186244 341 17015854 SGTC_1249 0481-0015 10.2 µM 0.495365147404456 0.362294731033902 no 1225 0.31017119598295 353 4227577 SGTC_865 0488-0499 301 µM 0.493441602865906 0.36285792595299 no 1226 0.310850296313261 323 9634651 SGTC_2786 7743617 45.45 µM 0.492981952599031 0.362992551006607 no 1227 0.311012669684195 321 583674 SGTC_2334 9017922 200 µM 0.492759176799795 0.363057804976193 no 1228 0.311091379403786 349 3163164 SGTC_1887 st057648 70.8 µM 0.490570179214678 0.363699202426641 no 1229 0.311865241147495 357 688672 SGTC_3023 9089636 49.47 µM 0.490279606144069 0.363784371915843 no 1230 0.311968028082654 348 17249241 SGTC_1416 3966-0321 25.3 µM 0.488998890856371 0.364159840843807 no 1231 0.312421241048073 324 582530 YLR208W SEC13 SGTC_2643 anethole 100 µM 0.488034100624523 0.36444277577547 no 1232 0.312762843607839 373 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_261 5-fluorouridine 15.376 µM 0.487475302188186 0.36460668311701 no 1233 0.312960770545649 312 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2378 9074213 121.43 µM 0.486818535184757 0.364799358344786 no 1234 0.313193466971655 337 657714 SGTC_2996 9066192 71.4286 µM 0.484337788826363 0.365527440737437 no 1235 0.314073080765029 324 6472854 SGTC_568 1193-0097 7.48 µM 0.483990751510831 0.365629332570768 no 1236 0.314196216373312 329 3646150 SGTC_1989 st071868 50.2 µM 0.483312730991278 0.365828430025504 no 1237 0.31443685094941 357 16414057 SGTC_1942 st076330 65.2 µM 0.480965804512451 0.366517872435058 no 1238 0.315270401228866 360 24208414 SGTC_2350 9023895 38.85 µM 0.480258555981959 0.366725721169189 no 1239 0.315521777159251 342 2997209 SGTC_2326 6164455 177.58 µM 0.479805134305981 0.366858994921994 no 1240 0.315682980848921 364 2888790 SGTC_1878 temozolomide 1 mM 0.479666837336176 0.366899647598723 no 1241 0.31573215614997 351 5394 DNA alkylating agent. SGTC_2962 9082311 13.18 µM 0.479296237854677 0.36700859343163 no 1242 0.315863949096571 360 16459453 SGTC_2826 7992541 19.48 µM 0.479217893659352 0.367031625795166 no 1243 0.315891812933444 387 2985066 SGTC_3184 9108758 49.47 µM 0.477961129616283 0.367401166476115 no 1244 0.316338935579238 347 902885 SGTC_1228 0124-0032 52.5 µM 0.477945308782103 0.367405819240224 no 1245 0.316344565917472 354 X1228 SGTC_3179 9107801 49.47 µM 0.47749522751951 0.367538192216854 no 1246 0.316504759228997 310 4818259 SGTC_2998 9066762 71.4286 µM 0.477466404522057 0.36754666985794 no 1247 0.316515019108477 374 4945196 SGTC_3106 9121286 49.47 µM 0.477337259140215 0.367584655880688 no 1248 0.316560991635183 309 15943471 SGTC_3068 9116768 49.47 µM 0.475443216809925 0.368141906409373 no 1249 0.317235548612166 362 41904888 SGTC_596 1155-0152 116 µM 0.474310096410264 0.368475417128295 no 1250 0.317639396393262 346 280313 SGTC_786 4544-0069 423 µM 0.473982495557448 0.36857185819182 no 1251 0.31775619487407 341 748821 YLR208W SEC13 SGTC_1232 0279-0259 161 µM 0.471119785897397 0.369414951133117 no 1252 0.318777598230329 360 1560000 SGTC_160 3453-0671 289.699 µM 0.47011934854491 0.369709737032902 no 1253 0.319134875655625 349 5322268 SGTC_2174 5790901 200 µM 0.469721628800348 0.369826949238095 no 1254 0.319276956529055 355 786020 SGTC_986 1493-0483 84 µM 0.466205675373044 0.370863662744385 no 1255 0.320534143683727 367 40079 SGTC_1968 st069590 43.6 µM 0.464872557847335 0.37125699128141 no 1256 0.321011361754029 352 6384066 SGTC_2033 5192550 145 µM 0.464480563537655 0.371372672520133 no 1257 0.321151740855741 316 182073 SGTC_2568 diosmetin 100 µM 0.464396773961106 0.371397401126614 no 1258 0.321181750489126 364 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1578 josamycin 24.2 µM 0.463870181494565 0.371552825181261 no 1259 0.321370378797483 335 5282165 A P450 substrate. SGTC_1931 st074438 57.1 µM 0.463180853653144 0.371756312318796 no 1260 0.321617369446694 367 2787313 SGTC_3177 9107506 49.47 µM 0.46183518762399 0.372153651375787 no 1261 0.322099757524773 357 8897194 SGTC_163 TUB2.036 7.546 µM 0.461618373352907 0.372217683557836 no 1262 0.322177508162148 344 15992207 YJR013W GPI14 SGTC_1337 1486-1011 40.3 µM 0.461508251293435 0.372250207473853 no 1263 0.322217001441045 341 X1337 SGTC_3159 9100096 49.47 µM 0.46044544416145 0.372564148245623 no 1264 0.322598261048347 325 25236875 SGTC_1660 st012960 28.1 µM 0.459029719536196 0.372982468216313 no 1265 0.323106412156582 369 24207266 SGTC_1014 4130-3005 69.3 µM 0.45647926948156 0.373736455929415 no 1266 0.324022687377009 363 743608 SGTC_392 N-ethylmaleimide 8.33 µM 0.456374663008297 0.373767391006849 no 1267 0.324060291139599 332 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1947 st076332 61.6 µM 0.456169450263461 0.373828080551888 no 1268 0.324134065893962 348 24208416 SGTC_2276 7947513 42.08 µM 0.451934994539235 0.375081073222666 no 1269 0.325657906655676 352 2105100 SGTC_867 0518-0118 155 µM 0.449548547273129 0.375787814916295 no 1270 0.326517997696564 351 6848158 SGTC_670 4204-0025 119 µM 0.44938394872375 0.375836575851119 no 1271 0.326577354158112 382 719039 SGTC_896 0964-0007 44.5 µM 0.447216905581565 0.376478728762815 no 1272 0.327359228143856 354 6756758 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.446781776282398 0.376607710512986 no 1273 0.327516315252163 376 279621 SGTC_1934 st074720 32.6 µM 0.44574408851419 0.37691535922343 no 1274 0.327891056711184 348 17250992 SGTC_1583 clindamycin 39.6 µM 0.444647983536202 0.3772404120782 no 1275 0.32828708273158 368 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2251 lansoprazole 556 µM 0.443149915062149 0.377684808948061 no 1276 0.328828651538955 371 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_332 4112-0506 40.9 µM 0.442678822814668 0.37782459034647 no 1277 0.328999031127148 377 2790355 SGTC_1051 3253-3903 78 µM 0.439902492697057 0.378648701003168 no 1278 0.330003865213708 354 5509239 SGTC_2450 5739737 12.93 µM 0.439752157655856 0.378693341426506 no 1279 0.330058310911782 356 2262825 SGTC_307 1501-1223 22.3 µM 0.439628797654255 0.37872997310202 no 1280 0.33010298995371 372 2830329 SGTC_2846 9008642 19.48 µM 0.43868738387522 0.379009561196875 no 1281 0.330444034904214 383 2992898 SGTC_3304 9125678 46.087 µM 0.437505229718816 0.379360735821664 no 1282 0.330872492100968 352 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2380 9035439 200 µM 0.435340154393347 0.380004158227756 no 1283 0.331657771328036 357 6462575 SGTC_1447 4239-0816 81.9 µM 0.434920025563658 0.380129051695811 no 1284 0.331810239179664 342 1341554 SGTC_3029 9088683 49.47 µM 0.434550711282955 0.380238849633291 no 1285 0.331944289068134 331 25236615 SGTC_1142 3253-1408 9.78 µM 0.43437546076548 0.380290955369698 no 1286 0.332007907221372 376 256655 SGTC_1885 st057546 99.9 µM 0.434216249355831 0.380338294218737 no 1287 0.332065707174258 353 702008 SGTC_905 2-aminofluorene 215 µM 0.434025782233808 0.380394928785485 no 1288 0.332134859419674 346 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.433800549382119 0.380461904098627 no 1289 0.332216641316655 361 97141 SGTC_1741 st038134 10.228 µM 0.431813231707246 0.381053008607615 no 1290 0.332938580958769 366 1272587 SGTC_2245 6637752 200 µM 0.431160915567542 0.381247093046499 no 1291 0.333175685281899 381 681890 SGTC_3088 9117578 49.47 µM 0.430394154600872 0.381475266588758 no 1292 0.333454473358235 358 678341 SGTC_3268 9137683 49.47 µM 0.429810744206828 0.381648906076978 no 1293 0.333666658301941 389 1953228 SGTC_2992 9074591 71.4286 µM 0.429105385893774 0.381858872531084 no 1294 0.333923266462478 357 17741321 SGTC_1420 4'-methoxyflavone 42 µM 0.428824588135043 0.381942468249617 no 1295 0.334025441834908 372 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2904 7225135 42.03 µM 0.428192452580495 0.382130680155213 no 1296 0.33425550537531 388 4446116 SGTC_273 hydroxyurea 18.1 mM 0.426364840924344 0.382674989410821 no 1297 0.334921008357904 373 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2822 7994718 71.43 µM 0.424227951826767 0.383311703303121 no 1298 0.335699788796814 392 1018011 SGTC_56 0957-0365 83.25 µM 0.423220552590645 0.383611980475714 no 1299 0.336067176457308 353 6752360 SGTC_184 1494-0393 24.714 µM 0.421984550527349 0.383980493169404 no 1300 0.336518147109016 359 3090647 SGTC_1123 mangostin 811.285 nM 0.419488483047548 0.384725012617224 no 1301 0.337429584960556 351 5281650 An antioxidant. SGTC_293 4049-0273 38.5 µM 0.415594755727108 0.385887270145475 no 1302 0.338853282405798 350 1380311 SGTC_1321 1326-2144 215 µM 0.415302094956883 0.385974669424612 no 1303 0.338960383899511 396 3513030 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.414264583372647 0.386284555175725 no 1304 0.339340174191806 384 165506 SGTC_2268 7933382 153.85 µM 0.413421774419683 0.386536340224639 no 1305 0.339648812065131 342 935025 YOR257W CDC31 SGTC_1082 camptothecin 424.86 nM 0.413416366142834 0.386537956075255 no 1306 0.339650792931547 385 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2143 5623677 140.463 µM 0.413087823594515 0.386636119620508 no 1307 0.339771135109587 364 5375313 SGTC_837 0091-0265 12.5 µM 0.412961271411434 0.386673933434705 no 1308 0.339817494393189 380 759367 SGTC_3022 9087993 49.47 µM 0.411754746465058 0.38703449727801 no 1309 0.340259596742229 381 17173644 SGTC_2677 mitomycin C 100 µM 0.410475872406592 0.38741678873105 no 1310 0.340728449532576 378 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1758 st042942 75.2445 µM 0.409848987780783 0.387604222096389 no 1311 0.34095836399965 371 669317 SGTC_3144 9087057 49.47 µM 0.40837083627903 0.38804628092079 no 1312 0.341500720498274 408 17249618 SGTC_2088 5278280 127.392 µM 0.408131681430195 0.388117816681569 no 1313 0.34158850089158 359 791502 SGTC_2124 5246320 200 µM 0.408051984776851 0.388141656308802 no 1314 0.341617754987306 384 579342 SGTC_988 1497-1057 103 µM 0.405089681132833 0.389028067264343 no 1315 0.342705795587682 399 3533044 SGTC_3290 9121031 71.43 µM 0.404409739114685 0.38923160822299 no 1316 0.342955719823167 371 17014854 SGTC_2081 5214970 32.255 µM 0.404226156485783 0.389286568982058 no 1317 0.343023210524074 362 2063512 SGTC_2898 9056270 58.44 µM 0.40400076661523 0.389354048974571 no 1318 0.343106077720297 371 19154699 SGTC_1976 st070609 63.5 µM 0.401438447737586 0.390121421642899 no 1319 0.344048673592814 385 682556 SGTC_189 3970-0742 2.116 µM 0.40074933826577 0.390327871897156 no 1320 0.344302340860408 403 2891807 SGTC_380 3970-0968 6 µM 0.400474102610672 0.390410338373419 no 1321 0.344403677115677 375 2891601 SGTC_2795 7780010 54.55 µM 0.398983985574964 0.390856894760291 no 1322 0.344952502142412 362 953673 SGTC_833 3852-0053 558 µM 0.398781601743966 0.390917556007577 no 1323 0.345027067332065 375 3123681 SGTC_229 benomyl 22.8748 µM 0.396825805091194 0.391503910664181 no 1324 0.345747960045561 362 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1480 1070-0044 41.2 µM 0.396371012882962 0.391640294342212 no 1325 0.34591567350757 370 3124987 SGTC_1278 0874-0585 172 µM 0.394539940692681 0.39218953325543 no 1326 0.3465912225811 367 766306 SGTC_1096 rimcazole 32.2 µM 0.393377343960221 0.392538371330009 no 1327 0.347020400283558 393 18528119 A dopamine reuptake inhibitor. SGTC_2775 cyproheptadine 69.59 µM 0.393016743229436 0.392646587425057 no 1328 0.347153557544394 397 2913 A selective serotonin reuptake inhibitor. SGTC_2789 5281112 71.43 µM 0.392835750358321 0.392700906422119 no 1329 0.347220399007443 359 765948 SGTC_2215 7188065 200 µM 0.392702313336415 0.392740954449454 no 1330 0.347269680929955 396 940217 SGTC_3258 9138477 49.47 µM 0.390447298712094 0.39341791621501 no 1331 0.348102909176633 392 4970355 SGTC_1113 artemisinin 1.17947 µM 0.389740377564379 0.393630202402619 no 1332 0.348364267924574 382 2240 An anti-malaria and mitochondrial poison. SGTC_697 0508-1955 564 µM 0.386063795907508 0.394734776777399 no 1333 0.349724710944672 370 6243113 SGTC_171 k064-0041 9.68 µM 0.384576658530201 0.395181806146996 no 1334 0.350275545156176 356 53325 SGTC_1300 1094-0077 113 µM 0.384447401877378 0.395220666864469 no 1335 0.350323436592215 382 5532636 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.383109593860107 0.395622936931536 no 1336 0.350819253232254 373 6708514 SGTC_569 4130-2812 160 µM 0.382281166998891 0.395872095225784 no 1337 0.351126411185112 388 743552 SGTC_1739 st037196 92.5 µM 0.380949460004868 0.396272709578967 no 1338 0.351620375428301 393 612214 SGTC_2005 4024620 188 µM 0.379560974290426 0.396690521203587 no 1339 0.352135667258735 392 236743 SGTC_2909 7941780 10.49 µM 0.378965308568863 0.396869800394268 no 1340 0.35235681275273 372 1243215 SGTC_3337 9144342 33.5465 µM 0.378100330515494 0.397130174078289 no 1341 0.352678031397345 358 17682949 SGTC_2223 6903751 107.57 µM 0.377990670947888 0.397163186824195 no 1342 0.352718762133396 390 5598863 SGTC_1835 st008666 49.2 µM 0.377296544488229 0.397372168988784 no 1343 0.352976619932006 368 690455 SGTC_664 1222-0054 14.9 µM 0.375605860591954 0.397881310040239 no 1344 0.35360496658478 368 6813991 SGTC_657 3534-0529 86.7 µM 0.373964577705382 0.398375740654383 no 1345 0.354215335072493 395 1049549 SGTC_1204 4049-0315 18.3 µM 0.373545069994359 0.3985021420733 no 1346 0.354371403887764 365 588402 SGTC_2717 st081029 62.2815 µM 0.370192544368946 0.399512669521635 no 1347 0.355619515673933 417 5292846 SGTC_834 0312-0008 75.7 µM 0.36921770458341 0.399806635102673 no 1348 0.355982730195438 387 6385573 YIL048W NEO1 SGTC_1810 st050138 53 µM 0.368294954800866 0.40008494513124 no 1349 0.356326657023989 418 3444541 SGTC_2247 cerulenin 830 nM 0.364934001005335 0.401099068560251 no 1350 0.357580336455899 359 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1252 0493-0875 34.8 µM 0.364730849026393 0.401160388423594 no 1351 0.357656164217968 366 3960963 SGTC_3001 9076041 71.4286 µM 0.364348795771988 0.40127571485572 no 1352 0.357798783230783 372 16004211 SGTC_335 4077-0256 27.6 µM 0.363989787547684 0.40138409276404 no 1353 0.357932817716481 404 3121989 SGTC_628 1636-0253 16 µM 0.362606818649953 0.401801656199913 no 1354 0.358449307966587 390 4456143 SGTC_502 l-744,832 89.3 µM 0.362582340193503 0.401809048055921 no 1355 0.358458452145152 421 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2607 solasodine 47.35 µM 0.359567638923236 0.402719677060022 no 1356 0.359585243751107 369 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_536 3852-0578 10.6 µM 0.358218496456998 0.403127374087259 no 1357 0.360089903149507 381 2869208 SGTC_572 0960-0087 17.7 µM 0.358076701277229 0.403170229261879 no 1358 0.36014295714804 403 6796365 SGTC_2007 4011539 71.82 µM 0.357680557934177 0.40328996299254 no 1359 0.360291192174006 377 45595301 SGTC_483 fpl-64176 144 µM 0.35667602686599 0.403593621621384 no 1360 0.360667177221997 406 3423 SGTC_2760 etidronate 98.04 µM 0.354684328651438 0.404195861661407 no 1361 0.361413046277472 396 3305 A chelator and antioxidant. SGTC_2381 9035592 200 µM 0.353703341454339 0.404492571380095 no 1362 0.361780609083183 388 4749657 SGTC_3248 9135562 49.47 µM 0.353247894145581 0.404630344810469 no 1363 0.361951302486685 363 17650701 SGTC_522 1273-0010 11.6 µM 0.352352827645304 0.404901138084395 no 1364 0.362286837196402 417 5705015 SGTC_639 0833-0042 114 µM 0.352267083601595 0.404927081466058 no 1365 0.362318985733159 415 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2235 salicylic acid 500 µM 0.35103407519186 0.405300196191823 no 1366 0.362781392369857 369 338 A COX inhibitor and kinase inhibitor. SGTC_357 1325-0123 420 µM 0.350335700408261 0.405511566223943 no 1367 0.363043387889135 409 1098503 SGTC_2735 sertaconazole 140 nM 0.349945662528751 0.405629627040863 no 1368 0.36318973862982 395 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3288 9119690 36.221 µM 0.343153388473486 0.40768695232629 no 1369 0.365741534276346 411 17595618 YKL019W RAM2 SGTC_1458 k015-0034 6.33 µM 0.342863935422063 0.407774682345981 no 1370 0.365850412180088 400 3598957 SGTC_967 1306-0166 352 µM 0.34229852701577 0.407946064719075 no 1371 0.366063121984903 407 4437607 SGTC_1418 3966-3099 2.4 µM 0.341673844696004 0.408135434238491 no 1372 0.366298178837051 412 740335 SGTC_2751 anetholtrithion 17.25 µM 0.340448637879011 0.40850691222581 no 1373 0.366759348019268 402 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_703 3875-0075 71.8 µM 0.340219720248479 0.40857632829621 no 1374 0.366845534216075 410 2850814 SGTC_1997 st073024 93.8 µM 0.339986677019307 0.408646998343106 no 1375 0.366933280572671 412 686268 SGTC_476 mead acid 10 µM 0.3385558041016 0.409080973666351 no 1376 0.36747219072996 409 5312531 An omega 9 fatty acid. SGTC_2106 5357045 167.29 µM 0.338436301049595 0.409117223288556 no 1377 0.367517211033973 390 668842 SGTC_2811 7967822 32.47 µM 0.337735847017662 0.409329712092688 no 1378 0.367781129204187 376 2232244 SGTC_2414 st077232 92.9 µM 0.337290778422323 0.409464741356644 no 1379 0.3679488552986 351 729801 SGTC_1594 piperine 70.1 µM 0.337067735109608 0.409532414459744 no 1380 0.368032919643757 388 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1303 1160-0052 261 µM 0.332048509951689 0.411055996199124 no 1381 0.369926314686812 404 3562476 SGTC_247 mechlorethamine 29.705 µM 0.332013065704275 0.411066760072883 no 1382 0.369939696548857 399 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2175 5807670 165.306 µM 0.331699352253304 0.411162032949579 no 1383 0.370058144920602 382 241186 SGTC_718 1130-0073 349 µM 0.329798400500623 0.411739452373555 no 1384 0.370776148019667 403 6740020 SGTC_1782 st039423 80.636 µM 0.328596967455935 0.412104489708778 no 1385 0.371230170259287 407 2068169 SGTC_14 0354-0009 295 µM 0.327890043009578 0.412319313619968 no 1386 0.371497401230164 428 1713507 SGTC_2702 st077768 96.8 µM 0.326783164481926 0.412655730427072 no 1387 0.371915946891331 361 6484119 SGTC_2774 tamoxifen 10.92 µM 0.324608797345515 0.413316778772688 no 1388 0.372738584096994 384 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1933 st074711 15.9 µM 0.324460123078198 0.413361987534684 no 1389 0.372794853895102 419 17250958 SGTC_1053 3366-3204 134 µM 0.324275580734586 0.413418104632731 no 1390 0.37286470271255 390 3632071 YPR165W RHO1 SGTC_607 4491-0986 66.8 µM 0.323659094728012 0.413605583399446 no 1391 0.373098071424805 385 698981 YDR232W HEM1 SGTC_2658 polymyxin b sulfate 77.05 µM 0.32312828467326 0.41376702314527 no 1392 0.373299045106356 393 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2830 7992007 71.43 µM 0.322236023532169 0.41403842689369 no 1393 0.373636947946713 377 1952075 SGTC_1692 fluoroquinolonic acid 71 µM 0.321460484593138 0.414274359997393 no 1394 0.373930726565944 414 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.318898581508206 0.415053957140395 no 1395 0.374901710001039 419 5282309 SGTC_486 niguldipine 82 µM 0.318544041893822 0.415161871360183 no 1396 0.375036146224524 407 1236 A calcium channel blocker. SGTC_194 1486-1323 56.904 µM 0.31711980349002 0.415595443267571 no 1397 0.375576349401058 401 5178754 SGTC_2906 7926292 26.41 µM 0.317081768411942 0.415607023457667 no 1398 0.37559077917712 425 2966319 SGTC_2102 5377816 72.7585 µM 0.316356556118754 0.41582783617905 no 1399 0.375865944024582 428 1379702 SGTC_2828 7998861 71.43 µM 0.316336911361487 0.415833817987006 no 1400 0.375873398647276 417 2988188 SGTC_1831 st055328 12 µM 0.315035097376678 0.416230262377547 no 1401 0.376367502893808 410 1103068 SGTC_2629 bisabolol 100 µM 0.313234962198722 0.416778602016534 no 1402 0.377051078985532 439 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2524 avocatin b 10.57 µM 0.312797196905475 0.416911974337213 no 1403 0.377217372574284 422 6710748 SGTC_3166 9102297 49.47 µM 0.310291266778891 0.417675630341872 no 1404 0.378169735873635 407 25237072 SGTC_2203 7227154 166.4 µM 0.310007698619422 0.417762064386787 no 1405 0.378277550963474 398 896304 SGTC_874 0599-0792 117 µM 0.308940091331465 0.41808751598985 no 1406 0.378683549527215 433 765305 SGTC_1195 1502-0147 41.1 µM 0.308042546811067 0.418361168723599 no 1407 0.379024978855801 399 817940 SGTC_1368 1852-0141 284 µM 0.307434108632552 0.418546698184779 no 1408 0.379256484747753 408 2838987 SGTC_2384 9036245 200 µM 0.306819977167544 0.418733982061183 no 1409 0.379490200807794 405 6462766 SGTC_1074 carmofur 3.8 µM 0.305788900795502 0.419048457737058 no 1410 0.379882689912825 407 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.30457827558517 0.41941776136294 no 1411 0.38034368394986 408 2724278 An inhibitor of dopamine biosynthesis. SGTC_2400 5203494 178.7 µM 0.304392169063285 0.419474539831117 no 1412 0.380414566554179 399 6777674 SGTC_411 enrofloxacin 100 µM 0.299179282157879 0.421065594918417 no 1413 0.382401628098134 436 71188 A bacterial gyrase inhibitor. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.298548446353506 0.421258223944444 no 1414 0.38264230304641 422 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2397 5161689 200 µM 0.296685018115124 0.421827341446939 no 1415 0.383353498068172 400 2259942 SGTC_1250 0485-0349 40.2 µM 0.296495511556068 0.421885228615117 no 1416 0.383425847109983 402 6842794 YDL195W SEC31 SGTC_2155 5570423 76 µM 0.295464668731236 0.422200142084977 no 1417 0.383819469222065 422 797402 SGTC_1503 4585-0012 61.3 µM 0.295371129579094 0.422228719942817 no 1418 0.383855192613162 408 2922052 SGTC_2178 5812956 200 µM 0.295110489382822 0.422308352271156 no 1419 0.383954738508183 400 5403383 SGTC_1571 st070080 73.4 µM 0.294289421769394 0.422559230431566 no 1420 0.384268377579466 391 4315245 SGTC_2953 9074162 66.49 µM 0.293031664702466 0.422943600451661 no 1421 0.384748974279676 442 16451992 SGTC_1097 itavastatin 7.23 µM 0.290085430046011 0.423844255089054 no 1422 0.385875440968584 412 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_981 1488-1094 54.9 µM 0.288674773475804 0.424275629529546 no 1423 0.386415134528475 400 3449522 SGTC_1939 st074455 53.6 µM 0.287627536509094 0.424595930082851 no 1424 0.386815932061783 449 1644229 SGTC_2051 5263410 176 µM 0.287478454730016 0.424641531244155 no 1425 0.386872998325361 409 227584 SGTC_2715 st079500 56.4 µM 0.286716044189371 0.424874753272531 no 1426 0.387164875829274 423 28246688 SGTC_2931 9014674 55.67 µM 0.285130093003166 0.425359981241027 no 1427 0.387772237832226 405 2996810 SGTC_965 1291-5240 308 µM 0.2847558662238 0.425474493904277 no 1428 0.387915593278752 414 2834598 SGTC_1043 0916-0009 19.3 µM 0.284558608824293 0.425534856813977 no 1429 0.387991163028404 437 3101130 SGTC_2809 7964133 12.99 µM 0.283234829266174 0.425939992847752 no 1430 0.388498415551047 437 1253665 SGTC_204 PMA1.184 62.41 µM 0.282659677757205 0.426116039445696 no 1431 0.388718864331548 406 2252213 YGL008C PMA1 SGTC_1977 st070720 65.3 µM 0.280985419981726 0.42662859225956 no 1432 0.38936079134543 401 682188 SGTC_1301 naphtanilide LB 4.81 µM 0.280626997571405 0.426738334875588 no 1433 0.389498253357951 428 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1176 0848-0131 83.3 µM 0.280423846562383 0.426800538647832 no 1434 0.389576171888313 446 6769040 SGTC_2287 7945887 168.79 µM 0.278340704625533 0.427438490545096 no 1435 0.390375416184669 424 1245853 SGTC_1666 st014829 29 µM 0.277892378737127 0.427575813001171 no 1436 0.390547487230921 415 3858230 SGTC_2452 5863136 48.41 µM 0.274980277805416 0.428468003926699 no 1437 0.391665695236584 429 2184096 SGTC_3095 9117207 49.47 µM 0.271309313078059 0.429593211280907 no 1438 0.393076572104963 440 17015229 SGTC_1705 st027868 56.3335 µM 0.271280396880256 0.429602076825216 no 1439 0.393087691189208 455 292948 SGTC_130 0136-0219 337.655 µM 0.271179489207686 0.429633014830602 no 1440 0.393126493685857 455 234244 SGTC_82 0054-0107 293.755 µM 0.270335412703511 0.429891823194411 no 1441 0.393451111903189 401 3104697 SGTC_1711 st032263 62.8 µM 0.269899866262178 0.430025381010616 no 1442 0.393618645032662 440 3958979 SGTC_1163 k060-0048 49.9 µM 0.268812948072229 0.430358713126263 no 1443 0.394036814429554 405 6809982 SGTC_711 k292-0785 179 µM 0.268455664597227 0.430468294372802 no 1444 0.394174298599238 434 4146315 SGTC_248 streptozotocin 5.23457 mM 0.268065745487573 0.430587891298607 no 1445 0.394324356145826 432 5300 DNA alkylating agent. SGTC_751 0833-0568 350 µM 0.267221138787059 0.43084697291253 no 1446 0.394649450678229 442 6954252 SGTC_2339 9000433 200 µM 0.263686395094192 0.43193157098284 no 1447 0.396010789880582 396 2988954 SGTC_537 1334-0398 209 µM 0.263039963313191 0.432129977376138 no 1448 0.396259888540028 430 5846986 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.262396507182537 0.432327487466979 no 1449 0.396507882618028 399 641818 YHR062C RPP1 SGTC_418 lividomycin a 100 µM 0.261803088418774 0.432509653484546 no 1450 0.396736628940923 414 72394 An antibiotic. SGTC_989 1501-0895 10.3 µM 0.260415367634547 0.432935708032599 no 1451 0.397271695064256 455 2830112 SGTC_2151 5563267 85.4165 µM 0.260322591553747 0.432964194697835 no 1452 0.397307473820643 459 5310824 SGTC_10 0279-0212 42.575 µM 0.257029627570952 0.433975515642728 no 1453 0.398577950853301 420 39851 YBR002C RER2 SGTC_742 0kpi-0133 140 µM 0.253722658496621 0.43499157288706 no 1454 0.399854913896123 453 2728852 SGTC_2919 7978188 46.38 µM 0.252530658740435 0.435357917209798 no 1455 0.400315459785449 415 2980291 SGTC_3097 9117246 49.47 µM 0.251544813971512 0.435660944640192 no 1456 0.400696459576094 403 16423892 SGTC_934 2950-0684 338 µM 0.250221664350694 0.436067711660953 no 1457 0.401207966155561 460 1121253 SGTC_2312 7706453 155.7 µM 0.249582595912277 0.436264200436165 no 1458 0.401455079586191 431 976098 SGTC_295 k015-0027 31 µM 0.246235094199739 0.437293683358856 no 1459 0.402750125230403 421 3887424 SGTC_3116 9124943 49.47 µM 0.244678323049244 0.437772594261677 no 1460 0.403352756823905 406 41905195 YPL160W CDC60 SGTC_459 nigericin 15.3 µM 0.244541798551287 0.437814597773497 no 1461 0.403405616907778 446 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1331 1472-0049 76.2 µM 0.24350289074082 0.438134253998976 no 1462 0.403807923003179 447 24051409 SGTC_1735 st034310 56.75 µM 0.242871010103439 0.438328693874686 no 1463 0.40405266192475 469 871153 SGTC_2343 7990716 14.84 µM 0.242544508410978 0.438429169554663 no 1464 0.404179136723223 435 6456862 SGTC_3194 9111903 49.47 µM 0.242325922906724 0.438496437969913 no 1465 0.404263814340664 453 17087251 SGTC_2222 6885208 172.143 µM 0.241961382769694 0.43860862702458 no 1466 0.404405043151638 419 609514 SGTC_394 menadione 8.33 µM 0.240892971309124 0.438937464390919 no 1467 0.404819034919456 454 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1185 1319-0113 81.3 µM 0.240468218943638 0.439068207066727 no 1468 0.404983649063598 439 4672763 SGTC_3301 9125354 19.7965 µM 0.239299919097075 0.439427854728087 no 1469 0.405436514068343 407 41905162 SGTC_2197 6588183 93.1375 µM 0.23911510700401 0.43948475159192 no 1470 0.405508163909979 415 884136 SGTC_2521 angolensin 13.4 µM 0.236510604001492 0.440286714931498 no 1471 0.406518239928656 439 821428 A flavenoid. SGTC_841 0251-0215 91.2 µM 0.236280131850903 0.440357692417146 no 1472 0.406607651500531 458 3888614 SGTC_991 3996-0057 64.7 µM 0.236246916828417 0.440367921658305 no 1473 0.406620537655778 400 715343 SGTC_161 4065-0411 162.148 µM 0.236066155682372 0.440423591424071 no 1474 0.406690667822184 440 1906281 YLR208W SEC13 SGTC_1386 3228-0095 33.8 µM 0.2355484133622 0.440583049203944 no 1475 0.406891553621827 452 870181 SGTC_1470 k295-0292 231 µM 0.235364432164641 0.440639715298632 no 1476 0.406962944861429 443 5045612 SGTC_3036 9090181 49.47 µM 0.234729081508184 0.440835412246646 no 1477 0.407209507241177 430 25236586 SGTC_1211 1056-0033 32.3 µM 0.234542264202081 0.440892957358451 no 1478 0.407282012977652 449 6741922 SGTC_428 3448-4153 16.5 µM 0.234296374744039 0.44096870029697 no 1479 0.407377450072058 396 3834874 SGTC_419 nsc-638432 893 µM 0.233407906837947 0.441242398857167 no 1480 0.407722336976239 409 368090 SGTC_3293 9120939 62.045 µM 0.23207812225747 0.441652100406973 no 1481 0.40823866846548 441 934087 SGTC_2493 resveratrol 26.09 µM 0.228207109126695 0.442845098620838 no 1482 0.409742617483561 442 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_808 0711-0032 135 µM 0.227874006153952 0.442947781200355 no 1483 0.409872095600291 457 4252555 SGTC_3046 9092212 49.47 µM 0.226026734898038 0.44351729182659 no 1484 0.410590313445767 447 25236637 SGTC_1822 st052468 42 µM 0.220593405936601 0.445193050015103 no 1485 0.412704517945771 447 2873678 SGTC_2262 9014885 67.46 µM 0.218416867118026 0.445864619028799 no 1486 0.41355216235795 459 6457424 SGTC_1136 pergolide 1.05886 µM 0.217564405458804 0.446127687717136 no 1487 0.413884260227351 479 47811 A dopamine receptor agonist. SGTC_2267 7931562 200 µM 0.217100600807202 0.446270827268569 no 1488 0.414064972877931 416 934880 SGTC_1853 st056710 91.2 µM 0.216934636354283 0.446322048977206 no 1489 0.414129642189409 470 269167 SGTC_836 0330-0104 1.35 µM 0.216623901875765 0.446417953553452 no 1490 0.414250728501927 401 46494820 SGTC_1572 epiandrosterone 68.9 µM 0.216548002797425 0.44644137939614 no 1491 0.414280305923052 438 441302 A steroid. SGTC_3294 9122953 26.2835 µM 0.215996206905124 0.446611693847379 no 1492 0.414495352116998 463 16459826 SGTC_2080 5212524 12.4 µM 0.213635881615708 0.447340330360446 no 1493 0.415415507915552 437 260183 SGTC_2929 9013348 24.6 µM 0.212718447958295 0.447623591833739 no 1494 0.415773288337188 437 2995952 SGTC_1013 4112-3890 241 µM 0.212035057778956 0.44783460877492 no 1495 0.416039841970729 422 705171 SGTC_2052 5265182 7.135 µM 0.211872901011612 0.44788468164494 no 1496 0.416103096250395 468 1239884 SGTC_892 0929-0076 29 µM 0.211555612754091 0.447982660430291 no 1497 0.416226870667251 434 5751038 SGTC_714 4296-0578 26.1 µM 0.211298760133473 0.448061978983035 no 1498 0.416327075177124 444 1589775 SGTC_3011 9081274 71.4286 µM 0.210581534278008 0.448283476191686 no 1499 0.416606911358409 432 6625322 SGTC_1079 idarubicin 2.36 µM 0.208877692773218 0.448809729410882 no 1500 0.417271859320568 471 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_44 0929-0055 61.211 µM 0.208713987171605 0.448860296735366 no 1501 0.417335760212332 453 1379590 SGTC_2482 5981709 142.65 µM 0.207764869469883 0.449153487793236 no 1502 0.417706282062999 453 877755 SGTC_715 0868-0130 184 µM 0.207229510105634 0.449318877409665 no 1503 0.417915310884372 435 2876258 SGTC_1150 3909-7983 10.9 µM 0.206224882199523 0.449629262819397 no 1504 0.418307626190557 449 23965914 SGTC_283 0987-0079 11.7 µM 0.203425163748391 0.450494413529621 no 1505 0.419401366575604 468 411556 SGTC_1216 1165-0504 9.65 µM 0.202604319033981 0.450748110390086 no 1506 0.419722156958429 450 6304004 SGTC_2683 piperine 63.03 µM 0.201352334021104 0.451135097653157 no 1507 0.420211541891009 483 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1299 1079-1439 3.74 µM 0.201185898372271 0.451186546244654 no 1508 0.420276608765435 442 323161 SGTC_1334 1486-0610 236 µM 0.200518630259905 0.451392820404021 no 1509 0.420537494513777 435 3742339 SGTC_881 0833-0569 170 µM 0.199418919025203 0.451732805337329 no 1510 0.420967531222178 416 5418700 SGTC_193 1273-0060 1.558 µM 0.199199608786242 0.451800611175578 no 1511 0.421053302716489 467 2847393 YHR072W ERG7 SGTC_2754 granisetron 64.02 µM 0.198781111838045 0.451930005005137 no 1512 0.421216985854837 472 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_259 usnic acid 108.925 µM 0.198185776905505 0.452114083642032 no 1513 0.421449857581533 475 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2841 9004761 38.96 µM 0.197635188795233 0.452284335644525 no 1514 0.421665250561475 417 2991039 SGTC_2443 5493264 126.67 µM 0.197091411713582 0.452452490163503 no 1515 0.421878002037509 455 5340055 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.191733811505896 0.454109695100765 no 1516 0.42397535978411 478 5393153 SGTC_2623 humulene 100 µM 0.191595844143345 0.454152381639839 no 1517 0.424029399049375 435 6187145 An anti-inflammatory. SGTC_903 1134-0042 114 µM 0.19140148415647 0.454212516725178 no 1518 0.424105528686447 437 701009 SGTC_1116 jasmonic acid  1.58368 µM 0.190964663253212 0.454347673177763 no 1519 0.424276639136379 470 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3030 9087619 49.47 µM 0.190478554719659 0.454498085895643 no 1520 0.424467073199686 484 25236973 SGTC_797 k781-0471 270 µM 0.18906585858846 0.454935242241394 no 1521 0.425020599877149 450 23738129 SGTC_1820 st053765 18.6 µM 0.187712652529797 0.45535404067841 no 1522 0.425550955650375 445 3690829 SGTC_2172 5754775 163.918 µM 0.186227080721031 0.455813861593903 no 1523 0.426133344031138 477 2263357 SGTC_488 nitrendipine 139 µM 0.185692532165035 0.455979331997664 no 1524 0.426342942469239 453 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2674 ligustilide 100 µM 0.184948845492373 0.456209554151541 no 1525 0.426634579321872 457 5319022 A signalling regulator. SGTC_2899 9053889 58.44 µM 0.184662906075309 0.456298075976883 no 1526 0.42674672119764 473 6470052 SGTC_1903 st060211 78.3 µM 0.184081992907188 0.456477923173919 no 1527 0.426974566328232 447 688960 SGTC_3172 9105863 49.47 µM 0.183075246240122 0.456789626936459 no 1528 0.427369489071988 470 2348785 SGTC_946 3434-1334 87.4 µM 0.180914384526988 0.457458751442404 no 1529 0.428217388970536 443 4047976 SGTC_1707 st032323 6.317 µM 0.180487770532644 0.457590869481939 no 1530 0.428384827221045 454 3132057 YMR211W DML1 SGTC_3224 9130643 49.47 µM 0.179375200171055 0.457935443283099 no 1531 0.428821551478264 429 17644395 SGTC_2908 7930301 100 µM 0.178480249360364 0.458212641162715 no 1532 0.429172915444055 431 2223178 SGTC_373 0844-0104 25.9 µM 0.178310823794385 0.45826512053749 no 1533 0.42923943943665 457 5375804 SGTC_727 3032-0951 202 µM 0.178251329097359 0.458283549124306 no 1534 0.429262800170646 472 3652836 SGTC_2920 7982904 15.77 µM 0.177962730527854 0.458372944309467 no 1535 0.42937612259811 464 6456808 SGTC_3074 9116018 49.47 µM 0.177577534684183 0.458492264375282 no 1536 0.429527384417805 480 17027303 SGTC_1821 st053465 65.6 µM 0.177113836412378 0.458635906680614 no 1537 0.429709486928929 436 675086 SGTC_1302 1159-0335 255 µM 0.175933015313727 0.459001720325124 no 1538 0.430173283704386 459 649284 SGTC_1722 st034304 3.6505 µM 0.175474201190107 0.459143868485084 no 1539 0.43035352036129 463 4036148 YLR033W RSC58 SGTC_858 0438-0351 2.77 µM 0.174058141812914 0.459582619826465 no 1540 0.430909884488455 475 2799119 SGTC_2537 larixol 68.93 µM 0.173977358221574 0.459607651275437 no 1541 0.430941628187339 492 6708759 SGTC_3336 9143619 71.43 µM 0.17329814554688 0.459818117137463 no 1542 0.431208540639404 480 45595730 SGTC_1164 k060-0068 93.7 µM 0.173128481995575 0.459870692100045 no 1543 0.43127521879558 479 5963676 SGTC_1881 5652484 16 µM 0.173073547591561 0.459887715200968 no 1544 0.4312968085594 471 2255129 SGTC_1122 capsaicin 818.572 nM 0.172145819603633 0.460175211101229 no 1545 0.431661445783928 481 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2372 9071633 200 µM 0.172068436782084 0.460199192396371 no 1546 0.431691863215375 481 21321366 SGTC_794 k038-0031 316 µM 0.170791008802383 0.460595094106808 no 1547 0.432194049567607 475 6624242 SGTC_1305 1181-0477 144 µM 0.170763774425749 0.460603535037741 no 1548 0.432204757223934 453 6252086 SGTC_2889 9059656 51.95 µM 0.170490539576755 0.460688221508082 no 1549 0.432312186886159 449 3949838 SGTC_2122 5258151 111.688 µM 0.169741257414376 0.460920463327062 no 1550 0.432606813066056 442 2173356 SGTC_1362 1611-0397 101 µM 0.16617535884126 0.462025903535765 no 1551 0.434009475307032 447 27816 SGTC_1961 st076550 68.7 µM 0.16583020868792 0.46213291692134 no 1552 0.434145286081038 448 1579337 SGTC_2666 tannic acid 100 µM 0.165745674056159 0.462159127199388 no 1553 0.434178550221026 476 16134267 A thiamine antagonist. SGTC_1348 1493-0373 93.8 µM 0.16520391616432 0.462327105151723 no 1554 0.434391741483484 481 3010129 SGTC_6 0844-0013 19.835 µM 0.164483415780621 0.462550514571372 no 1555 0.434675300614557 479 1584900 SGTC_2054 5233173 129 µM 0.164455216968269 0.462559258569111 no 1556 0.434686399184328 456 6889 SGTC_1602 st001878 87.6 µM 0.163699875329664 0.462793484570707 no 1557 0.434983707848208 492 595405 YLR310C CDC25 SGTC_1199 1638-0010 4.46 µM 0.162870034795781 0.463050827012272 no 1558 0.435310382264177 456 3111136 SGTC_1864 st057645 30.4 µM 0.162400300799522 0.463196503418945 no 1559 0.43549531698974 482 688666 SGTC_1005 4092-0690 4.4 µM 0.160630056279446 0.46374554525721 no 1560 0.436192390398426 466 1529343 SGTC_2938 9059746 27.26 µM 0.158834632478277 0.464302466988358 no 1561 0.436899581196151 464 6471769 SGTC_2063 5246145 200 µM 0.158705986446096 0.464342374343833 no 1562 0.436950260729967 468 711240 SGTC_2356 9061756 188.97 µM 0.158638949781038 0.464363169966283 no 1563 0.436976669936982 457 20104043 SGTC_2515 chrysin 20.77 µM 0.158224850972563 0.464491630816667 no 1564 0.437139811080857 448 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1101 ebselen 5.29 µM 0.157246343369351 0.464795196044005 no 1565 0.437525352922468 481 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.156484775832473 0.465031473520328 no 1566 0.437825459268616 459 23665772 A membrane-active detergent. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.15557762330614 0.465312935042764 no 1567 0.438182982079743 491 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2154 5570129 200 µM 0.155005996101144 0.465490302301703 no 1568 0.438408295118767 496 673366 SGTC_3253 9135987 49.47 µM 0.153770003875231 0.465873835350169 no 1569 0.438895542968676 475 4182430 SGTC_1898 st060199 18.6 µM 0.15134785677388 0.466625528324984 no 1570 0.439850659898107 449 688866 SGTC_2883 9059145 45.46 µM 0.150530649044497 0.466879168863244 no 1571 0.4401729858904 487 16476510 SGTC_2244 6635614 200 µM 0.149667736623146 0.467147009575843 no 1572 0.440513381928244 449 836499 SGTC_3008 9078912 71.4286 µM 0.149035045363409 0.467343401047562 no 1573 0.440762989779991 486 16648731 SGTC_2071 5230951 39.92 µM 0.147810579097206 0.467723505859203 no 1574 0.441246130070047 498 1799272 SGTC_2499 avocadenofuran 51.48 µM 0.147021715314668 0.467968404425746 no 1575 0.441557440113988 452 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_166 k072-0058 166.424 µM 0.146022973552511 0.468278475873867 no 1576 0.441951626270555 505 5846229 SGTC_3230 9131665 49.47 µM 0.143422340212956 0.469085963748444 no 1577 0.442978320212389 491 15943720 SGTC_925 2064-1272 59.6 µM 0.143324528696125 0.469116336396619 no 1578 0.4430169423577 471 6815817 SGTC_269 exalamide 29 µM 0.141041273842639 0.469825388428484 no 1579 0.443918668206217 458 3316 A derivative of salicylamide. SGTC_2928 9011484 9.79 µM 0.140527012327096 0.46998510275161 no 1580 0.444121805746853 484 2994751 SGTC_2915 7971052 15.16 µM 0.139327713625433 0.470357587957356 no 1581 0.444595595575669 497 5741558 SGTC_1724 st037281 8.293 µM 0.135085992194208 0.471675212510847 no 1582 0.446271942633616 477 574124 YDL195W SEC31 SGTC_146 3448-8650 53.125 µM 0.134754423047903 0.471778222544067 no 1583 0.446403021097534 511 2891488 YIL048W NEO1 SGTC_2227 7312221 64.1025 µM 0.132583718364054 0.472452651162611 no 1584 0.447261304796799 504 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_771 0250-0039 27.3 µM 0.132328601453857 0.472531920114891 no 1585 0.447362192803638 503 3005115 SGTC_2281 7943571 200 µM 0.128961522656612 0.47357822672281 no 1586 0.448694047499616 499 1244024 SGTC_871 0574-0004 149 µM 0.128453893543821 0.473735986481663 no 1587 0.448894891744617 497 9551173 SGTC_1453 4237-0541 195 µM 0.128335288480838 0.473772846873375 no 1588 0.448941819910916 467 739892 SGTC_1504 k297-0033 30 µM 0.127840961628895 0.473926477480088 no 1589 0.449137416655631 454 4388117 SGTC_2740 felodipine 17.08 µM 0.125735473761873 0.474580879947344 no 1590 0.449970660345337 501 3333 L-type calcium channel blocker SGTC_73 0327-0325 16.231 µM 0.125630112869325 0.474613628772004 no 1591 0.450012362588193 489 53298 SGTC_410 α-linolenic acid 100 µM 0.124226441648989 0.475049941494024 no 1592 0.450567993492349 508 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_526 4469-0568 170 µM 0.123259399373007 0.475350551296649 no 1593 0.450950845107549 470 2901964 SGTC_405 ebelactone b 50 µM 0.121995063623396 0.475743597363303 no 1594 0.451451463864065 492 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1648 st011736 69.8 µM 0.121820411261091 0.475797893685275 no 1595 0.451520624248153 485 2855514 SGTC_2942 9052777 62.25 µM 0.121055332580397 0.476035748361366 no 1596 0.451823604171434 498 6469503 SGTC_3324 9138759 60.749 µM 0.120496101901386 0.476209612530001 no 1597 0.452045083690114 478 45595710 SGTC_1036 k216-0215 33.5 µM 0.119810821773789 0.476422671498304 no 1598 0.452316504581385 485 622330 SGTC_791 1348-1292 225 µM 0.117779878149967 0.47705414716294 no 1599 0.45312103673523 503 5437054 SGTC_2663 amphotericin b 100 µM 0.11607185337946 0.477585263237955 no 1600 0.453797797878854 491 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2089 5281248 129.67 µM 0.115335044757501 0.477814388716329 no 1601 0.454089780997338 465 2737878 SGTC_2362 9071156 126 µM 0.113717323745987 0.478317477262064 no 1602 0.45473093962189 477 653133 SGTC_196 k015-0023 18.111 µM 0.11310713451311 0.478507246572683 no 1603 0.454972809384804 479 5211998 SGTC_415 dibenzyl ketone 100 µM 0.110858346704894 0.479206663011822 no 1604 0.455864338227473 508 7593 SGTC_591 4299-0174 154 µM 0.109787700561428 0.479539677271914 no 1605 0.456288872803 499 5509088 SGTC_2975 9084847 53.72 µM 0.108817550480606 0.479841445531884 no 1606 0.456673601605929 470 27211724 SGTC_1390 3413-2614 145 µM 0.107884143710355 0.480131795576767 no 1607 0.457043797594671 506 3421432 SGTC_818 4072-2707 53.5 µM 0.10647683270085 0.480569580456484 no 1608 0.457602017864791 478 882871 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.10490693116899 0.481057971461354 no 1609 0.45822482952132 497 6708760 SGTC_2985 9022375 71.43 µM 0.104884124035358 0.481065066894039 no 1610 0.458233878331674 478 4939335 SGTC_1519 esterone 74 µM 0.104349808891194 0.481231297172546 no 1611 0.458445875925068 477 698 A steroid. SGTC_2327 6189656 200 µM 0.10419908391177 0.481278189669556 no 1612 0.458505680474387 508 5349088 SGTC_1978 st071761 42 µM 0.103206432910698 0.481587022718005 no 1613 0.458899567227075 464 5147680 SGTC_3130 9127414 49.47 µM 0.103056093395331 0.481633797235724 no 1614 0.458959225904441 508 1494646 SGTC_1655 st012546 55.1 µM 0.102392525434948 0.481840253429712 no 1615 0.459222558164853 504 720985 YLR208W SEC13 SGTC_920 mycophenolic acid 780.421 nM 0.10189633483925 0.481994636615507 no 1616 0.459419479598019 492 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.101444055906222 0.482135359617132 no 1617 0.459598982637713 489 77254 SGTC_1419 3993-2473 62.6 µM 0.0979388100638297 0.483226063187281 no 1618 0.460990441068045 507 704026 SGTC_702 1488-0190 94 µM 0.0978838316367791 0.483243171472763 no 1619 0.461012269405876 505 949357 SGTC_2105 5350118 200 µM 0.0959692091909168 0.483838986142377 no 1620 0.461772513582171 485 2133313 SGTC_4 0960-0234 25.671 µM 0.0954102704703451 0.484012930114031 no 1621 0.461994479319717 464 6821112 SGTC_2982 9019404 25.97 µM 0.0948233150674579 0.48419559626415 no 1622 0.462227583782855 436 22333232 SGTC_154 3389-1638 511.116 µM 0.0937033441070135 0.484544151137846 no 1623 0.462672406877553 515 5238686 SGTC_1450 4112-4260 37.6 µM 0.0930219438782536 0.484756220798592 no 1624 0.462943064056281 510 1633175 SGTC_554 4483-2211 187 µM 0.0928334832639992 0.484814875458894 no 1625 0.463017925031338 492 747107 SGTC_1744 st037937 38.9 µM 0.0900064827659223 0.485694762494339 no 1626 0.464141031619287 485 1016152 SGTC_379 3970-0972 5.9 µM 0.088321334676638 0.486219288189629 no 1627 0.464810641298204 500 2898042 YBL034C STU1 SGTC_1623 st003709 20.3 µM 0.0866089317063276 0.486752321763296 no 1628 0.465491183053301 513 16192618 SGTC_458 nppb 133 µM 0.0858392343428022 0.486991919477034 no 1629 0.46579710853525 493 4549 A chloride channel blocker. SGTC_1526 st051518 75 µM 0.0855273280837514 0.487089013559552 no 1630 0.465921085197637 474 673993 SGTC_3156 9099931 49.47 µM 0.0854393547889568 0.48711639912599 no 1631 0.465956053467181 491 18111053 SGTC_997 3996-0078 137 µM 0.0852076347304144 0.487188532500352 no 1632 0.466048160510412 492 735687 SGTC_716 1683-5115 658 µM 0.0843794585931551 0.487446343281824 no 1633 0.466377369351118 519 723597 SGTC_2466 5983409 37.09 µM 0.0836586066457164 0.487670748375606 no 1634 0.466663934417803 500 2879657 SGTC_2857 9024691 58.44 µM 0.0830375668225909 0.487864084550388 no 1635 0.466910834370891 508 16478292 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0816846442255285 0.488285273279013 no 1636 0.467448744840717 520 1273210 SGTC_788 1182-0090 188 µM 0.0809614118655704 0.488510433690774 no 1637 0.46773632029667 469 5715185 SGTC_2206 7254556 146.969 µM 0.0764240733253911 0.489923101898427 no 1638 0.469540858932971 513 4398905 SGTC_2969 9091408 28.7 µM 0.0742074094352165 0.49061329156024 no 1639 0.470422675116158 476 4286311 SGTC_322 k048-0136 19.3 µM 0.073533360815622 0.490823171801694 no 1640 0.470690848915486 489 6823282 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.071534592147717 0.491445548224675 no 1641 0.471486147256706 493 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3257 9139206 32.98 µM 0.06999997363224 0.491923411824967 no 1642 0.472096840312953 515 4910041 SGTC_2301 7769476 200 µM 0.066444931941059 0.49303045671357 no 1643 0.473511799350266 499 977820 SGTC_919 tnp00227 403.569 nM 0.0658768346025131 0.493207368204602 no 1644 0.473737941910271 509 1269246 A methoxyflavone. YNL221C POP1 SGTC_1358 1509-0022 2.48 µM 0.0658382140773274 0.493219395091558 no 1645 0.473753315894356 493 3258434 SGTC_2845 9003024 42.97 µM 0.065746243993869 0.493248035684855 no 1646 0.473789927324919 486 2990173 SGTC_1423 4048-0112 5.59 µM 0.0654948458803338 0.493326324266848 no 1647 0.47389000495929 524 X1423 SGTC_1007 4101-0031 70 µM 0.0652521616903111 0.49340189946569 no 1648 0.47398661528099 516 1146276 SGTC_369 0957-0393 4.5 µM 0.0647929917943699 0.493544891940387 no 1649 0.474169410732347 515 6997992 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0644544152040021 0.493650330361733 no 1650 0.474304201496545 526 91467 include heat shock SGTC_2553 4-methylesculetin 85.09 µM 0.0624833862107152 0.494264150377911 no 1651 0.475088945984603 480 5319502 SGTC_1000 4048-0884 8.67 µM 0.0624064833365864 0.494288099840238 no 1652 0.475119566034883 514 13040088 SGTC_55 0767-0285 6.563 µM 0.0617862593730781 0.494481253710249 no 1653 0.475366523005997 517 3116166 SGTC_2309 7664088 163.95 µM 0.0611152511815218 0.494690224565136 no 1654 0.47563371158442 515 704922 SGTC_234 nsc-17383 10.7 µM 0.0600250670428918 0.495029741700479 no 1655 0.476067835034502 517 408974 SGTC_2446 5162541 200 µM 0.0599251519909981 0.495060858528727 no 1656 0.476107623748469 517 1549321 SGTC_370 0180-0345 38.7 µM 0.0591977068700035 0.495287409721747 no 1657 0.476397318047013 495 3989527 SGTC_131 0141-0277 33.849 µM 0.0585280039108798 0.495495979383852 no 1658 0.47666402841347 507 1547771 SGTC_2045 5106652 78.05 µM 0.0576317798539736 0.495775097804134 no 1659 0.477020967535869 527 673349 SGTC_3311 9131146 2.8755 µM 0.0571659895139803 0.495920163541504 no 1660 0.477206485136658 500 4900406 YPR165W RHO1 SGTC_2091 4-phenylthiadiazole 200 µM 0.0569653079105765 0.495982663984843 no 1661 0.477286415261253 524 270010 SGTC_1015 4130-4525 82 µM 0.0566600598160691 0.496077730890582 no 1662 0.477407995262548 498 1363237 SGTC_1324 1418-0026 34.4 µM 0.0563783883608774 0.496165455251577 no 1663 0.477520186578412 516 1372513 SGTC_1376 2910-0861 41.3 µM 0.055632905047336 0.496397631054195 no 1664 0.477817125325427 517 1112859 SGTC_1167 k781-0610 148 µM 0.0549150326198496 0.496621208784784 no 1665 0.478103077826036 515 4525169 SGTC_2430 5571206 200 µM 0.0537841477282092 0.49697341928033 no 1666 0.478553569758932 530 1731771 SGTC_3207 9114163 49.47 µM 0.0534515953860799 0.497076992108658 no 1667 0.478686048381298 509 849233 SGTC_949 1165-0505 146 µM 0.0529774877915746 0.497224652404484 no 1668 0.478874922329589 520 6244267 SGTC_1491 4138-0063 26.5 µM 0.0521443591955108 0.49748413031041 no 1669 0.479206833747534 523 23883227 SGTC_1177 0983-0204 23.6 µM 0.0515743324335478 0.497661665768523 no 1670 0.479433935931984 522 766818 SGTC_1463 k081-0032 34.1 µM 0.0482081802898804 0.498710065802938 no 1671 0.480775165420457 528 977755 SGTC_2698 st077697 67.5 µM 0.0480750748272057 0.49875152220253 no 1672 0.480828205318539 527 3154499 SGTC_3124 9127567 49.47 µM 0.0467653680179465 0.499159437956533 no 1673 0.481350115568523 523 17592030 SGTC_1895 st058434 18.3 µM 0.045852808584019 0.499443660410503 no 1674 0.481713783939185 526 5393175 SGTC_532 1548-0774 215 µM 0.0453459076346932 0.499601538074283 no 1675 0.481915798024381 523 5932993 SGTC_1846 st056244 14.8 µM 0.0449569506845675 0.499722681340608 no 1676 0.482070811306473 507 5393182 SGTC_2978 9011784 42.97 µM 0.044520241206211 0.499858697483955 no 1677 0.48224485891128 508 2994934 SGTC_2259 7964009 200 µM 0.0442555570972045 0.499941135162615 no 1678 0.482350348619373 508 313134 SGTC_336 4111-0029 111 µM 0.0438775603649663 0.499941135162615 no 1679 0.482501001152603 526 3131175 SGTC_2801 7907800 81.82 µM 0.043745816186624 0.499900102535376 no 1680 0.482553509057795 531 6620925 SGTC_2029 5175081 200 µM 0.0433606064093263 0.499780126317904 no 1681 0.482707039839854 529 1380876 SGTC_1280 0880-0253 10.1 µM 0.0418542854034936 0.49931097263917 no 1682 0.483307429700608 520 6836607 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0415852011309506 0.499227164637471 no 1683 0.4834146854117 528 5379071 SGTC_757 1066-0008 322 µM 0.0407825583404426 0.498977176671655 no 1684 0.483734622109003 501 6842497 SGTC_1138 3761-0006 1.03 µM 0.0406045306821422 0.498921728928557 no 1685 0.483805586087637 528 12061087 SGTC_1838 st055369 84.5 µM 0.0395034933327401 0.498578804986481 no 1686 0.484244484207851 517 676036 SGTC_1720 st037298 9.481 µM 0.038618857678841 0.498303281252909 no 1687 0.484597133626895 524 597396 SGTC_424 splitomicin 100 mM 0.0383128935793844 0.498207987546489 no 1688 0.484719105372455 513 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_914 3820-6779 408 µM 0.0378798096509849 0.498073102051993 no 1689 0.484891755529289 539 2893481 SGTC_2366 9070441 60.58 µM 0.0374846032665685 0.497950013842029 no 1690 0.485049308166445 526 6837235 SGTC_1930 st074634 34.3 µM 0.0369264462785515 0.497776174514584 no 1691 0.485271826521235 492 684253 YOR116C RPO31 SGTC_557 1315-0110 16.2 µM 0.0362659273488079 0.497570454863962 no 1692 0.485535159047367 529 6833801 SGTC_1236 0330-0013 258 µM 0.0354488769328482 0.497315984137699 no 1693 0.485860905512335 526 4617066 SGTC_1120 ficusin 1.78878 µM 0.0348261367019466 0.497122032135439 no 1694 0.486109189597545 521 6199 A DNA cross-linker. SGTC_1608 st001473 40.5 µM 0.0347824735859696 0.497108433313991 no 1695 0.486126598113594 537 7292267 SGTC_76 0433-0009 400.328 µM 0.034579927611734 0.497045350674391 no 1696 0.486207353685874 531 2841569 SGTC_480 am 92016 50 µM 0.0341742337878634 0.496918998165775 no 1697 0.486369106497346 533 2129 K+ channel blocker. SGTC_2987 9018338 71.43 µM 0.0341130704436078 0.496899948994265 no 1698 0.48639349292252 532 5055682 SGTC_2055 5235184 200 µM 0.0331617196858064 0.496603654103044 no 1699 0.48677281229322 533 2836034 SGTC_2885 9057732 51.95 µM 0.0323206738216057 0.496341714843062 no 1700 0.487108161245463 518 6471414 SGTC_113 0099-0221 2.5 µM 0.0309986989747104 0.495929996041327 no 1701 0.487635288621637 536 89219 SGTC_893 0958-0369 48.9 µM 0.0308521172882103 0.495884344572171 no 1702 0.487693738297102 529 6819948 SGTC_2610 ononetin 44.17 µM 0.0294909940232626 0.495460438357179 no 1703 0.488236500773697 532 259632 SGTC_2644 guaiazulene 100 µM 0.0294050198260699 0.49543366284755 no 1704 0.488270784647515 531 3515 A coloring agent. SGTC_3132 9126706 49.47 µM 0.0289719879746238 0.495298801205493 no 1705 0.488443465785331 540 850858 SGTC_1713 st033146 12.748 µM 0.0288645632753305 0.495265345385703 no 1706 0.488486304123936 528 674619 SGTC_2451 5856223 45.7 µM 0.0275978652512783 0.49487085376079 no 1707 0.488991442150487 530 2179896 SGTC_2263 7948595 193.29 µM 0.0273885032919073 0.494805652000603 no 1708 0.489074933927191 526 2971371 SGTC_2412 st077135 33.4 µM 0.0262334763321527 0.494445943584878 no 1709 0.489535557406293 530 13258915 SGTC_1628 st004252 77.7 µM 0.026106903031737 0.494406525309865 no 1710 0.489586035558696 538 692968 SGTC_929 2805-0021 398 µM 0.0251590649281927 0.49411134520589 no 1711 0.489964044033419 528 3098024 SGTC_547 1120-0019 610 nM 0.0249507039771563 0.49404645690634 no 1712 0.490047141939888 540 3676939 SGTC_2696 st077691 74.316 µM 0.0236534493784684 0.493642466176612 no 1713 0.490564518809879 537 757133 SGTC_2195 6536160 144.242 µM 0.0235414904917213 0.493607600265509 no 1714 0.490609171509497 535 3834386 SGTC_3203 9113543 49.47 µM 0.0225357913744849 0.493294410590773 no 1715 0.491010280927476 530 17018012 SGTC_1022 4477-0945 21.3 µM 0.0219467745284574 0.493110983884489 no 1716 0.49124520653477 510 4648966 SGTC_931 2812-0076 566 µM 0.0219129582923687 0.493100453158548 no 1717 0.491258694017526 536 3450959 SGTC_878 0828-0289 13.7 µM 0.0211964280786894 0.492877319375376 no 1718 0.491544481811933 535 745350 YLR208W SEC13 SGTC_2056 5235370 200 µM 0.0208939570506723 0.492783127913448 no 1719 0.491665123574061 528 5511916 SGTC_1866 st057638 64 µM 0.0193408830306535 0.492299496928903 no 1720 0.492284585039005 537 688802 SGTC_1445 4239-0156 97.7 µM 0.0192325995479757 0.492265777605907 no 1721 0.492327775864719 539 4008346 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0191475616593263 0.492239296966668 no 1722 0.492361694827867 533 1609 A potent and irreversible inhibitor of serine proteases. SGTC_173 1273-0061 2.693 µM 0.0187521818102286 0.492116176873304 no 1723 0.4925194002471 535 2847414 YPL266W DIM1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0159075353263305 0.49123038538684 no 1724 0.493654079221347 541 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_533 1222-0222 6.71 µM 0.0153590048725574 0.49105958390228 no 1725 0.493872884469161 531 3982874 SGTC_3341 9147222 25.867 µM 0.0137564964326261 0.490560604119461 no 1726 0.494512125032049 539 1939759 SGTC_1703 st026983 48.3 µM 0.0122099117774637 0.490079051559484 no 1727 0.495129070980228 538 1104023 SGTC_2886 9058944 51.95 µM 0.0121370971752239 0.490056379981027 no 1728 0.495158117651332 546 4949929 SGTC_504 lovastatin 124 µM 0.0111599940498113 0.489752151968569 no 1729 0.495547898939528 539 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1281 0884-0031 11.8 µM 0.00944261031635633 0.489217446876865 no 1730 0.496232999486976 544 1548255 SGTC_294 k038-0071 157 µM 0.00911965936068464 0.489116898671336 no 1731 0.496361832728197 540 24152826 SGTC_1523 st012844 44.7 µM 0.00807780530485788 0.488792530463722 no 1732 0.496777456976739 541 4274103 SGTC_2427 5545055 42.75 µM 0.00720716203782515 0.488521472266857 no 1733 0.497124783232748 541 5372858 SGTC_2881 9058953 51.95 µM 0.00704334562442826 0.488470471735824 no 1734 0.497190134867255 544 17122249 SGTC_220 paclitaxel 373.376 µM 0.00651676891742818 0.488306535282499 no 1735 0.497400203748723 540 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2090 5301565 104.445 µM 0.0050030270647773 0.487835280814571 no 1736 0.498004089300238 538 2056344 SGTC_2037 5169046 200 µM 0.00468788227355632 0.487737172811367 no 1737 0.498129812405485 545 5718022 SGTC_1239 0337-0584 35.4 µM 0.00430340739677127 0.487617482603518 no 1738 0.498283194138649 546 914301 YML130C ERO1 SGTC_3242 9133940 49.47 µM 0.00404577638235822 0.487537280562114 no 1739 0.498385973147177 546 17248444 SGTC_2359 9039622 200 µM 0.00387956824218032 0.487485539263361 no 1740 0.498452280080961 545 6463596 SGTC_3265 9137266 49.47 µM 0.00347664294178176 0.487360107784962 no 1741 0.498613022930741 546 17224265 SGTC_784 4579-0127 173 µM 0.000629743173035371 0.486473898346679 no 1742 0.499748768839087 548 1948547 SGTC_2017 5132927 60.65 µM 9.20557012524495e-05 0.48630652935556 no 1743 0.49996327508867 548 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_470 aa-861 153 µM -0.00027598740051453 0.486191967906496 no 1744 0.499889896958474 548 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1182 1222-0449 220 µM -0.000335479756913631 0.486173449718709 no 1745 0.499866162943259 548 658318 SGTC_3344 9148862 3.898 µM -0.000736590663494119 0.486048596693431 no 1746 0.499706142867556 548 4905352 SGTC_764 1951-2361 146 µM -0.00094332814888695 0.485984246444777 no 1747 0.499623666572931 549 5438930 SGTC_3061 glucosamine 200 µM -0.00192500072222251 0.485678690640952 no 1748 0.4992320362964 547 91431 and experimental redox chemotherapeutic SGTC_430 0958-0115 16.4 µM -0.00430700862747011 0.484937301201557 no 1749 0.498281757468776 555 6833180 SGTC_922 1866-0035 480 µM -0.00577274136691935 0.484481124073571 no 1750 0.497697022185868 554 3156169 SGTC_1909 st060837 51.5 µM -0.00680896852029615 0.484158633347495 no 1751 0.497283635560719 553 678937 SGTC_669 0108-0021 26.2 µM -0.00772350346839481 0.483874023814267 no 1752 0.496918798547225 558 17201 SGTC_2571 chrysanthemic acid 100 µM -0.00973288799001555 0.483248718663464 no 1753 0.49611720077282 556 2743 An insecticide. SGTC_3228 9131799 49.47 µM -0.0111659629026387 0.482802781751124 no 1754 0.49554551786013 554 17015818 SGTC_2191 5911152 200 µM -0.0127057571555124 0.482323660452219 no 1755 0.494931272645922 558 2875902 SGTC_3153 9100258 49.47 µM -0.014048882886622 0.481905755213515 no 1756 0.494395490986086 552 25236848 SGTC_3049 9092223 49.47 µM -0.0152370599851329 0.481536077839333 no 1757 0.493921527748282 559 8623917 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0160330217739237 0.481288439220192 no 1758 0.493604023755542 554 2724 A muscle relaxant with antifungal properties. SGTC_904 1141-0088 396 µM -0.016430737201252 0.481164705201616 no 1759 0.493445379157792 568 1378119 SGTC_3262 9137218 49.47 µM -0.0165868670539944 0.481116131835403 no 1760 0.493383100845624 552 17650664 SGTC_1184 1269-1718 139 µM -0.017331117570349 0.480884592839746 no 1761 0.49308623054841 554 5403821 SGTC_1715 st032160 10.2275 µM -0.0173636297828375 0.480874478320677 no 1762 0.493073262003687 552 5289825 SGTC_1055 3448-0672 86 µM -0.0187953791946122 0.48042907471258 no 1763 0.492502170020774 558 748378 SGTC_119 0121-0043 24.815 µM -0.0195349060123068 0.480199024495972 no 1764 0.492207195689833 556 1092378 SGTC_2182 6325192 200 µM -0.0200310479852303 0.480044689540873 no 1765 0.492009302409938 555 736248 SGTC_2514 salinomycin 42.74 µM -0.0210111874286608 0.47973980623709 no 1766 0.491618365684485 561 23682228 A polyether potassium ionophore. SGTC_18 0111-0177 500 nM -0.0223482762198168 0.479323909006764 no 1767 0.491085069814888 557 721752 SGTC_3278 9139605 49.47 µM -0.0236978946074359 0.478904137313986 no 1768 0.490546792697654 583 7958859 SGTC_1850 st056238 17 µM -0.0250614518275532 0.478480053991265 no 1769 0.490002973751354 560 5393177 SGTC_129 0088-0017 176.636 µM -0.0264076760741571 0.478061385338793 no 1770 0.489466085832234 559 182446 SGTC_1607 st000305 50.6 µM -0.0268246080144675 0.477931726588995 no 1771 0.489299812960263 560 5457690 SGTC_2700 st077718 96.8 µM -0.0274361948373153 0.477741537707863 no 1772 0.489055914900454 565 904970 SGTC_3027 9089541 49.47 µM -0.0298108497988341 0.477003125230123 no 1773 0.488108952862666 562 9943819 SGTC_13 0199-0087 65 µM -0.0317745924651323 0.476392547800659 no 1774 0.487325904339072 557 4589825 SGTC_1025 k007-0731 70 µM -0.0318746654467392 0.47636143404312 no 1775 0.487286001207802 559 6256118 SGTC_1908 st060353 56.5 µM -0.032579872789995 0.47614218165413 no 1776 0.487004810247899 574 4227716 SGTC_36 0335-0881 14.2 µM -0.0326781810446784 0.476111617712293 no 1777 0.486965611800544 559 23828853 SGTC_2970 9090938 41.86 µM -0.0334430121851011 0.475873837260319 no 1778 0.486660655033577 576 17217104 SGTC_1610 st001799 48.1 µM -0.0346393974288142 0.475501907031429 no 1779 0.486183642866441 561 621897 SGTC_3310 9130229 44.1445 µM -0.0349572251297163 0.475403104866423 no 1780 0.486056924705366 589 7761258 SGTC_2013 4024628 200 µM -0.0353482936065216 0.475281536632349 no 1781 0.485901007321038 575 5230760 SGTC_1325 1431-0015 227 µM -0.0357566792901128 0.475154587597376 no 1782 0.48573818793896 568 1103340 SGTC_156 3474-0145 5.642 µM -0.0360038028517574 0.475077769043227 no 1783 0.485639663342277 559 2265471 SGTC_2261 9010538 184.68 µM -0.0361081388608862 0.475045336390438 no 1784 0.485598066344411 599 6457250 SGTC_2168 5727979 200 µM -0.0362592064300612 0.474998377612938 no 1785 0.485537838543705 564 695210 SGTC_61 0978-8327 98.565 µM -0.0366130296456893 0.474888394376803 no 1786 0.485396777170906 584 6150059 YHR072W ERG7 SGTC_491 tetrandrine 80.3 µM -0.0373086288951075 0.474672178265551 no 1787 0.485119462710436 577 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1291 0993-0025 5.79 µM -0.0392234493946156 0.474077025082388 no 1788 0.484356119053122 570 4353356 SGTC_453 enantio-paf c16 10 µM -0.0399828080698484 0.473841021655876 no 1789 0.484053416252668 576 13871343 A lipid and platelet activating factor SGTC_855 0428-0020 25 µM -0.0406721894604667 0.473626774633919 no 1790 0.48377861641941 566 6812414 SGTC_2741 miltefosine 3.04 µM -0.0409259701200792 0.473547906203073 no 1791 0.483677456813025 563 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3093 9117344 49.47 µM -0.0418348049418336 0.47326547249674 no 1792 0.483315194479497 566 24824913 SGTC_3129 9127257 49.47 µM -0.0440994706683332 0.47256175329007 no 1793 0.482412557360626 601 837894 SGTC_701 4424-0219 185 µM -0.0445113503304272 0.472433775492838 no 1794 0.482248402344867 578 2911779 SGTC_835 0312-0010 67.2 µM -0.0445653099447295 0.472417009562173 no 1795 0.482226896913634 572 1626196 SGTC_1006 4099-6547 255 µM -0.0447590383040548 0.472356816127862 no 1796 0.482149687523883 571 3146833 SGTC_2748 diazoxide 86.69 µM -0.0448502049652364 0.472328489907861 no 1797 0.482113353775662 566 3019 A potassium channel activatior. SGTC_199 4063-0024 41.6 µM -0.0451747412571844 0.47222765499034 no 1798 0.481984013623751 563 306215 SGTC_2232 chlorophetanol 41.5365 µM -0.0459732370851876 0.471979566257334 no 1799 0.481665790530189 577 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_519 k048-0011 62.8 µM -0.0471510487375804 0.471613645832207 no 1800 0.481196420771276 574 6836379 SGTC_1500 4488-1866 171 µM -0.0475756852274048 0.47148172638477 no 1801 0.48102720522908 575 2900003 SGTC_577 r071-0003 38.6 µM -0.0480598799760729 0.471331308124367 no 1802 0.480834260188224 565 4568517 YMR134W ERG29 SGTC_2237 6667747 47.222 µM -0.0501214394767635 0.470690917237421 no 1803 0.480012807488201 590 729940 YDL015C TSC13 SGTC_1985 st071382 65.5 µM -0.0521361749204944 0.470065144715038 no 1804 0.479210094365688 600 6123237 SGTC_695 3505-6186 243 µM -0.05467842146936 0.469275634050085 no 1805 0.478197330406254 577 1819379 SGTC_1495 4469-0029 237 µM -0.0557764761804791 0.468934663421412 no 1806 0.477759937526316 578 793680 SGTC_1451 4152-0210 104 µM -0.0562991211901666 0.468772378405192 no 1807 0.477551759457435 587 659563 SGTC_475 α-linolenic acid 10 µM -0.0574594395063913 0.468412109848203 no 1808 0.477089607642153 590 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2019 4016004 108 µM -0.0586391456572082 0.468045848060633 no 1809 0.476619765293267 581 45595336 SGTC_2120 5538279 151.968 µM -0.0601736592906561 0.467569470188039 no 1810 0.476008662264991 575 2058197 SGTC_1304 1165-0502 251 µM -0.0609251559912447 0.467336190756863 no 1811 0.475709407536121 570 767425 SGTC_876 0720-0963 56.8 µM -0.0618219300565735 0.467057829047456 no 1812 0.475352319614776 572 765861 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0661366861034062 0.465718741784272 no 1813 0.473634501744689 601 521171 SGTC_2534 helenine 20.12 µM -0.0663403033731704 0.465655558505665 no 1814 0.473553448214811 560 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3338 9144300 39.5675 µM -0.0667123747871765 0.465540105448807 no 1815 0.473405341302546 596 4901274 SGTC_1907 st060210 83.7 µM -0.0667552877220451 0.465526789832555 no 1816 0.473388259596702 596 688793 SGTC_2817 7995342 71.43 µM -0.0668761522201216 0.46548928653953 no 1817 0.473340149148904 587 18879975 SGTC_2213 7173844 200 µM -0.067175984919803 0.465396252160149 no 1818 0.473220801593797 574 892728 SGTC_2825 7998094 58.44 µM -0.0705997786650976 0.464334026647345 no 1819 0.471858143287276 595 2987815 SGTC_1364 1653-0028 37.6 µM -0.0711510256932658 0.464163026859527 no 1820 0.471638779204349 570 5718652 SGTC_1159 4092-0538 61.2 µM -0.0725520460311071 0.463728452692479 no 1821 0.471081293909117 570 717301 SGTC_511 blebbistatin 171 µM -0.073411367946054 0.463461926116216 no 1822 0.47073938584633 593 3476986 A myosin inhibitor. SGTC_456 gingerol 170 µM -0.0737318489698723 0.463362530178288 no 1823 0.470611877969939 603 442793 A herb. SGTC_674 0498-0004 451 µM -0.0759985328147201 0.462659592684848 no 1824 0.469710132734045 583 4231473 SGTC_1634 st006576 41 µM -0.0774392059822039 0.462212875717351 no 1825 0.469137076272196 574 3915356 SGTC_2749 bexarotene 57.39 µM -0.0781403666031923 0.461995480430797 no 1826 0.468858198717615 590 82146 An retinoic acid receptor inhibitor. SGTC_705 1124-0212 310 µM -0.0783103808049954 0.461942769129574 no 1827 0.468790580067475 576 9554485 SGTC_2072 5231554 129 µM -0.0794907208176431 0.461576834310865 no 1828 0.468321155986874 581 789545 SGTC_400 oxethazaine 37.5 µM -0.0803650721451674 0.461305784564045 no 1829 0.467973452706911 607 4621 A local anesthetic. SGTC_277 nystatin 15.5 µM -0.0819897379436575 0.460802184435814 no 1830 0.467327436957654 613 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_509 pifithrin 175 µM -0.0823914201057943 0.460677684065861 no 1831 0.467167729308847 576 4817 A p53 inhibitor. SGTC_2630 antimycin a 100 µM -0.0825186113518905 0.460638262263828 no 1832 0.46711715954325 607 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_237 nikkomycin 200 µM -0.0828773224465831 0.460527085017213 no 1833 0.466974543030502 605 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2402 5553605 200 µM -0.0828976227280953 0.460520793334646 no 1834 0.466966472162354 601 6758546 SGTC_2354 9060492 162 µM -0.0845100540072394 0.460021082913724 no 1835 0.466325454748582 597 6471895 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.085251443207874 0.459791339281984 no 1836 0.466030746818687 578 4000243 SGTC_998 3996-0085 177 µM -0.0860741170134932 0.45953642268016 no 1837 0.465703749439223 575 715391 SGTC_2377 9073351 62.6 µM -0.0863858408324118 0.459439835180111 no 1838 0.465579851115637 633 7337946 YHR072W ERG7 SGTC_356 1634-0012 32.5 µM -0.0884765617448313 0.458792088295498 no 1839 0.464748956144592 591 735457 SGTC_2087 5276107 200 µM -0.0885851378551854 0.458758452232284 no 1840 0.464705809958967 578 144405 SGTC_1429 4049-0205 9.46 µM -0.0919769628388614 0.457707840238679 no 1841 0.463358171491745 586 22774478 SGTC_879 0831-1030 162 µM -0.0925662941011332 0.457525325808453 no 1842 0.463124061076049 591 1549252 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0940873859920652 0.457054288911041 no 1843 0.462519870224782 581 5106787 A p450 inhibitor. SGTC_686 1319-0111 510 µM -0.0947765224873213 0.456840903662257 no 1844 0.462246167626847 600 4562600 SGTC_1614 st002383 48.6 µM -0.0949730011199491 0.456780068003417 no 1845 0.462168135974744 593 1947235 SGTC_956 1185-0240 191 µM -0.0953246522302395 0.456671188836011 no 1846 0.462028481081348 606 1416193 SGTC_2566 crystal violet carbinol 226 nM -0.0963388636454669 0.456357184204147 no 1847 0.461625722946499 600 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2236 dapsone 200 µM -0.0986353936050064 0.455646268733136 no 1848 0.460713883500587 589 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2320 7373003 200 µM -0.0987786213730356 0.455601935722406 no 1849 0.460657021569042 610 5415828 SGTC_2746 daunorubicin 9.88 µM -0.101295029314216 0.454823127570621 no 1850 0.459658130966349 585 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1527 coumarin 137 µM -0.101812498466495 0.454662996426976 no 1851 0.459452752431783 636 323 A hepatotoxic, DNA x-linker. SGTC_1378 2093-0007 380 nM -0.102593544376021 0.454421315256142 no 1852 0.459142783322833 585 3618014 SGTC_3354 9151612 71.43 µM -0.102667246948288 0.454398510137575 no 1853 0.459113534694793 604 27261949 SGTC_2139 5578692 56.4705 µM -0.103294821396266 0.454204331564304 no 1854 0.45886449278119 592 650991 YMR113W FOL3 SGTC_471 1-acyl-paf 4 µM -0.105406793310778 0.453550944425077 no 1855 0.45802651290663 591 16759367 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.105599677237278 0.453491277579428 no 1856 0.45794999042388 598 442882 SGTC_3021 9087658 49.47 µM -0.106404168039479 0.453242427180993 no 1857 0.457630843118114 589 25237042 SGTC_2564 betulinic acid 100 µM -0.107557314122043 0.452885760476721 no 1858 0.457173429441194 645 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_446 go6976 132 µM -0.107727229988267 0.452833208908447 no 1859 0.457106034399744 589 3501 A protein kinase C inhibitor. SGTC_720 r052-1644 49.9 µM -0.107948816323786 0.452764677942014 no 1860 0.457018146754924 610 1422863 YOR257W CDC31 SGTC_838 0109-0203 71.4 µM -0.108287020324433 0.452660082838045 no 1861 0.456884009175471 594 759422 SGTC_2594 a-mangostin 100 µM -0.108955049052499 0.452453493715911 no 1862 0.456619071830878 602 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2596 sinensetin 100 µM -0.10966788844719 0.452233061008633 no 1863 0.456336384036264 602 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.110120933677123 0.45209297260223 no 1864 0.456156733224276 578 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2394 5221648 200 µM -0.11042280582652 0.451999632498483 no 1865 0.456037033644515 610 788586 SGTC_558 k064-0027 21.3 µM -0.111101935360057 0.451789652574261 no 1866 0.455767757024925 606 5088526 SGTC_2107 5363541 170.161 µM -0.112849285318023 0.451249451920799 no 1867 0.455075021920115 598 244052 SGTC_1328 1441-0025 69.2 µM -0.113107628267467 0.451169591737684 no 1868 0.4549726136613 608 4562601 SGTC_1262 0737-0114 49.6 µM -0.113955892649192 0.450907386193087 no 1869 0.454636379083365 598 765919 SGTC_549 1661-1316 519 µM -0.116796668336148 0.450029435544147 no 1870 0.453510591982692 619 2857282 SGTC_622 1348-1566 26.3 µM -0.117854212970314 0.449702660278788 no 1871 0.453091586540399 613 7340407 SGTC_1940 st075990 51.1 µM -0.118136271304796 0.44961551161265 no 1872 0.452979842161187 617 1084979 SGTC_1382 3002-2117 298 µM -0.118652398110441 0.449456048190881 no 1873 0.452775375419632 610 1497314 SGTC_224 benfluorex 43.875 µM -0.12021914267473 0.44897203420933 no 1874 0.452154777044351 595 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_132 0417-1715 25.805 µM -0.12555248244309 0.447324980396795 no 1875 0.450043089360003 605 6769098 SGTC_1387 3342-1166 1.8 µM -0.125923039260154 0.447210577627181 no 1876 0.44989642257365 603 3418228 SGTC_1359 1582-0056 520 nM -0.128138100259137 0.446526809205698 no 1877 0.449019842458228 621 3661189 SGTC_481 bay k-8644 50 µM -0.128193474535909 0.446509717717282 no 1878 0.448997932014628 650 2303 A calcium channel antagonist. SGTC_2101 5377231 179.231 µM -0.128258101996063 0.44648977032307 no 1879 0.448972360476516 629 2844213 SGTC_1658 st012944 20 µM -0.128407999924732 0.446443504550348 no 1880 0.448913050272431 632 24207260 SGTC_3128 9127691 49.47 µM -0.12841497580962 0.446441351471602 no 1881 0.448910290147629 619 41316314 SGTC_752 1896-0090 130 µM -0.128657196869742 0.446366591897666 no 1882 0.448814452893592 607 772567 SGTC_3111 9122088 49.47 µM -0.129035193867582 0.446249929986841 no 1883 0.448664900462159 604 16876704 SGTC_1769 st044406 64.4 µM -0.129641183793947 0.446062911910128 no 1884 0.448425159112851 609 670903 SGTC_1673 st016611 27.3 µM -0.130659768371605 0.44574858765241 no 1885 0.448022229807861 612 5226799 SGTC_2109 5483026 200 µM -0.1308883589911 0.445678051720447 no 1886 0.447931811817797 598 759335 SGTC_2078 5212016 200 µM -0.130913355237283 0.445670338763132 no 1887 0.447921924829191 605 1899708 SGTC_902 1120-0002 2.07 µM -0.132010453648526 0.445331833300576 no 1888 0.447488011649614 610 3280475 SGTC_2048 5246248 200 µM -0.132547688258929 0.445166086164766 no 1889 0.447275552981033 602 677046 SGTC_1295 1013-0063 9.78 µM -0.133668002020934 0.44482047884527 no 1890 0.446832554369452 613 6826038 SGTC_2228 7354201 200 µM -0.134002458622834 0.444717309930397 no 1891 0.446700315135753 612 753451 SGTC_734 2023-0417 80 µM -0.134959312395773 0.444422172565941 no 1892 0.446322021973144 624 3935732 SGTC_1691 st019933 84.6 µM -0.135335828621932 0.444306046220506 no 1893 0.446173179254067 605 6176082 SGTC_1202 1988-0068 29.6 µM -0.136045412660372 0.444087207032353 no 1894 0.445892690281434 604 2850480 SGTC_2347 9049783 174.81 µM -0.136328577619732 0.443999882328713 no 1895 0.445780766553605 643 6467988 YPL169C MEX67 SGTC_289 k017-0060 526 µM -0.136466669956 0.443957297281558 no 1896 0.44572618576985 615 5512909 SGTC_2680 butyl paraben 22.24 µM -0.137180304489364 0.443737236302664 no 1897 0.445444139231789 619 7184 An antifungal and steroid mimetic. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.140728196988825 0.442643443961972 no 1898 0.444042334394822 659 61125 An anti-inflammatory. SGTC_329 k048-0121 21.3 µM -0.142367412778812 0.442138231420439 no 1899 0.44339490049952 615 6832902 SGTC_2428 5615643 7.78 µM -0.14237914069078 0.442134617171412 no 1900 0.443390268919667 607 2253075 SGTC_1752 st044819 83.042 µM -0.142682714703896 0.442041064933142 no 1901 0.44327038434808 613 441209 YML126C ERG13 SGTC_763 3453-1109 128 µM -0.145611854316949 0.441138560406659 no 1902 0.442113904671413 594 1560353 SGTC_406 estrone 100 µM -0.145954150040538 0.441033114667797 no 1903 0.441978791846102 603 5870 A steroid. SGTC_2470 5664817 21.68 µM -0.146110256823429 0.440985026657932 no 1904 0.441917174769951 612 2859561 SGTC_402 epigallocatechin gallate 10 µM -0.147334267573171 0.440608005728474 no 1905 0.441434092997673 631 65064 An antioxidant. SGTC_3052 9092717 49.47 µM -0.147690535419303 0.440498277874844 no 1906 0.441293500680876 632 25237534 SGTC_1737 st035557 69.7 µM -0.148191969619382 0.440343847603699 no 1907 0.441095634580338 605 5716916 SGTC_2442 5158906 48.48 µM -0.148764995200054 0.440167379934885 no 1908 0.440869536501414 600 1893835 SGTC_2614 arthonioic acid 13.39 µM -0.14893266726074 0.440115746270224 no 1909 0.440803381960734 633 6710684 SGTC_1562 morin hydrate 59.1 µM -0.151618848526684 0.43928869134855 no 1910 0.439743783153739 631 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3173 9105693 49.47 µM -0.152133542912493 0.439130250970519 no 1911 0.439540804348581 643 17096658 SGTC_738 1315-0003 72.4 µM -0.153181045337044 0.438807824363601 no 1912 0.439127752443255 650 6251474 SGTC_623 k072-0108 16.9 µM -0.155159920376953 0.438198827471497 no 1913 0.438347622235183 634 5382803 SGTC_1743 st037606 46.3785 µM -0.155162893049556 0.438197912744071 no 1914 0.438346450500424 615 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1994 st072947 40.9 µM -0.155475067027893 0.438101854862438 no 1915 0.438223404272035 650 5286565 YDL195W SEC31 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.155656597789043 0.438045998390781 no 1916 0.438151855007736 646 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3309 9129340 25.759 µM -0.157324685603208 0.437532790687035 no 1917 0.43749448310447 611 17158987 SGTC_2306 7482397 179.52 µM -0.158188598148106 0.43726703862823 no 1918 0.437154093995992 651 891448 SGTC_3193 9111931 49.47 µM -0.15902263756918 0.437010502825129 no 1919 0.436825519287149 629 17087244 SGTC_1603 st002045 67.8 µM -0.161186762846552 0.436344979866738 no 1920 0.435973153255649 642 5887985 SGTC_1109 tnp00067 928.257 nM -0.161424933531268 0.43627174736135 no 1921 0.43587936503624 603 676295 SGTC_142 0335-0849 62.6745 µM -0.162140362828336 0.436051780958634 no 1922 0.435597660884934 604 3889043 YPR107C YTH1 SGTC_2341 7987486 176.74 µM -0.164481778538091 0.435332026249664 no 1923 0.434675945003779 613 1258686 SGTC_228 caffeine 993.056 µM -0.164861864674258 0.435215207344553 no 1924 0.434526354594007 627 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_440 fluspirilene 35.1 µM -0.165865710516477 0.434906704039661 no 1925 0.434131316350316 643 3396 An atypical antipsychotic. SGTC_1457 k015-0032 57.3 µM -0.166434163011281 0.434732023985884 no 1926 0.433907645332841 613 4302660 SGTC_1198 1612-1005 86.7 µM -0.16807113031876 0.434229070758222 no 1927 0.433263660457371 617 6998509 SGTC_817 1391-0715 46 µM -0.168907343145326 0.433972187934698 no 1928 0.432934761598073 617 1353946 SGTC_450 aminopyrene 156 nM -0.170788487925522 0.433394406286794 no 1929 0.432195040690939 616 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2545 solidagenone 89.61 µM -0.171042846196876 0.433316292658236 no 1930 0.432095037792309 619 6708572 An anti ulcer agent SGTC_1107 amlodipine 47 µM -0.171383750488264 0.433211604763504 no 1931 0.43196101548845 635 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_40 0327-0103 19.753 µM -0.173233224631353 0.432643733806258 no 1932 0.43123405447335 633 409036 SGTC_112 phenothiazine 287.218 µM -0.175184668843864 0.432044704316532 no 1933 0.430467265267949 636 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_301 4119-0100 24.5 µM -0.175368364263364 0.431988323858861 no 1934 0.43039509850492 644 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_812 4251-0442 148 µM -0.176912370902708 0.431514486658786 no 1935 0.429788610660099 652 5723007 SGTC_688 0527-0193 473 µM -0.177175637296021 0.431433703160204 no 1936 0.429685215764407 619 4007154 SGTC_552 k242-0005 476 µM -0.17807913567 0.431156485807701 no 1937 0.429330413724463 646 4088318 SGTC_540 1187-0821 17.3 µM -0.179035427422306 0.430863106984829 no 1938 0.428954942015807 628 847520 SGTC_605 1315-0399 119 µM -0.179405325261506 0.430749636993863 no 1939 0.428809725136127 625 24020461 SGTC_2812 7970281 58.44 µM -0.181083328296916 0.430234964118722 no 1940 0.428151085177227 652 2233435 SGTC_1762 st045503 25.4615 µM -0.181613494951519 0.430072377328761 no 1941 0.427943028769894 643 4645554 SGTC_2692 st077426 47.7 µM -0.182162288559243 0.429904090679474 no 1942 0.427727683578781 645 25238571 SGTC_2946 9065502 71.43 µM -0.184647326255046 0.429142217816564 no 1943 0.42675283157917 616 16489101 SGTC_1476 4112-3294 3.34 µM -0.186756608428259 0.428495752531708 no 1944 0.425925734856883 611 704369 SGTC_1801 st050089 28.441 µM -0.187777489459002 0.428182935649457 no 1945 0.425525541332859 635 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1011 4112-3381 17.4 µM -0.187992913412766 0.428116931513671 no 1946 0.425441103208926 669 2877139 SGTC_1877 wortmannin 25 µM -0.189260500683764 0.427728593943136 no 1947 0.424944325842492 642 312145 A covalent inhibitor of PI 3-kinase. SGTC_1092 toremifene 6.32 µM -0.190388440381224 0.427383097596473 no 1948 0.424502377624292 671 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3073 9114972 49.47 µM -0.190413961228439 0.427375281013751 no 1949 0.424492379166962 619 41905075 SGTC_465 cgp-37157 41 µM -0.191986439008173 0.426893714081349 no 1950 0.423876413967714 636 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_60 0986-0278 202 µM -0.192377818730763 0.426773872037233 no 1951 0.423723132985594 634 3110598 SGTC_359 0081-0058 15.9 µM -0.192575416887012 0.426713369254677 no 1952 0.423645749507572 624 3494159 SGTC_2575 plumbagin 510 nM -0.192851291253277 0.426628901883459 no 1953 0.423537716391251 655 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1088 bifonazole 369 nM -0.192928168235245 0.426605364244481 no 1954 0.423507612189649 618 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1514 1189-1591 158 µM -0.19312644449653 0.426544658657759 no 1955 0.423429971393551 686 767698 YMR146C TIF34 SGTC_2431 5490079 200 µM -0.19370564919958 0.42636733544186 no 1956 0.42320318410333 671 5722345 SGTC_2110 5483698 200 µM -0.19376589319817 0.426348892627263 no 1957 0.423179597057612 626 2848765 YHR062C RPP1 SGTC_1811 st050069 61.5 µM -0.195064817136682 0.425951285395829 no 1958 0.422671102661465 634 3877702 SGTC_201 4262-0159 12.803 µM -0.195481512887341 0.425823748631897 no 1959 0.422508004539306 655 1341029 SGTC_1854 st056233 32.9 µM -0.196160919662346 0.425615821371852 no 1960 0.422242107676005 662 5393174 SGTC_1251 0490-5699 265 µM -0.196537532022603 0.425500570939046 no 1961 0.422094729576772 634 3883818 SGTC_944 3370-0224 231 µM -0.197482272871243 0.425211490584323 no 1962 0.421725076241088 643 4580514 SGTC_1920 st075728 45.7 µM -0.197637916038975 0.425163869332699 no 1963 0.421664183591488 605 3400306 SGTC_1350 1495-0454 146 µM -0.197692320672387 0.425147223715063 no 1964 0.42164289917807 621 1069057 SGTC_3035 9091303 49.47 µM -0.198443062219319 0.424917540800792 no 1965 0.421349214259726 636 25237002 SGTC_304 1310-0298 97 µM -0.198959022364313 0.424759702007727 no 1966 0.421147399564068 638 1550234 SGTC_2137 5261020 140 µM -0.205144452796102 0.422868446038284 no 1967 0.418729633302083 641 763655 SGTC_1118 chelidonine 707.474 nM -0.205176552401836 0.422858635864983 no 1968 0.418717094101316 629 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_33 0986-0033 35.816 µM -0.206552421632783 0.422438192395416 no 1969 0.418179710448828 626 2848082 SGTC_2293 7624732 200 µM -0.206923800676027 0.422324720067 no 1970 0.418034684257067 623 894453 SGTC_185 k048-0037 25.491 µM -0.207183939389197 0.422245240299916 no 1971 0.417933104851601 619 6827589 SGTC_825 1988-2224 89.6 µM -0.207512627748884 0.422144821196405 no 1972 0.417804765893503 648 1180859 SGTC_3215 9129942 49.47 µM -0.20779466681125 0.422058658170173 no 1973 0.417694648498348 655 17682944 SGTC_1126 isoteolin 1.0172 µM -0.209388824194857 0.421571712815104 no 1974 0.417072358202868 624 133323 SGTC_2132 5317594 122.667 µM -0.209546207006022 0.421523645741227 no 1975 0.41701093397973 632 794577 SGTC_766 1391-0721 126 µM -0.211014438577912 0.42107528220427 no 1976 0.416438002334319 681 1020919 YIL115C NUP159 SGTC_2129 girgensonine 121.053 µM -0.211197957370201 0.421019247046472 no 1977 0.416366402294895 658 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.211497072567577 0.42092791940803 no 1978 0.416249708151618 653 5282362 SGTC_2014 4013930 200 µM -0.214499131315215 0.42001154935977 no 1979 0.415078922155139 672 64556 SGTC_959 1222-0044 107 µM -0.215131958002488 0.419818435933587 no 1980 0.414832219155962 658 6083612 SGTC_2140 5586273 200 µM -0.216096546287898 0.419524119275503 no 1981 0.414456245889878 628 854421 SGTC_2914 7968218 45.32 µM -0.217842052650763 0.418991642234037 no 1982 0.413776089008683 667 2977111 SGTC_826 1683-5028 118 µM -0.21796165319039 0.418955162801806 no 1983 0.413729494708923 664 722377 SGTC_3256 9138902 49.47 µM -0.219222421932534 0.418570657418779 no 1984 0.413238395043874 646 17228773 SGTC_222 nsc-310342 10.666 µM -0.220229681309984 0.418263522424206 no 1985 0.412846140846757 644 432556 SGTC_555 4296-0685 37 µM -0.221132425827063 0.417988298591216 no 1986 0.412494661498146 663 2908540 YHR072W ERG7 SGTC_3167 9103034 49.47 µM -0.22221488545797 0.417658337149173 no 1987 0.412073303433401 633 5127859 SGTC_435 c-PAF 6.7 µM -0.222388903625854 0.41760529735329 no 1988 0.412005574592041 653 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_404 fumagillin 50 µM -0.225213802017065 0.41674449394653 no 1989 0.410906476393101 646 12015870 A methionine aminopeptidase binder. SGTC_1886 st057356 49.9 µM -0.228664373172155 0.415693577216132 no 1990 0.40956489361978 633 24207747 SGTC_2641 levomentholum 100 µM -0.229358748125703 0.415482168812778 no 1991 0.409295047898289 638 16666 SGTC_3314 9135860 59.4275 µM -0.230259522430018 0.415207956818209 no 1992 0.408945055985809 635 25252478 SGTC_1573 oleylamine 1.06 µM -0.231929108247735 0.414699813995039 no 1993 0.408296537877418 672 5356789 An amine of the fatty acid oleic acid. SGTC_2099 5377090 177.372 µM -0.232391549718905 0.414559093920751 no 1994 0.40811695581974 667 2243829 SGTC_804 1595-0054 20.9 µM -0.232638489212138 0.414483955184797 no 1995 0.408021068553905 680 761523 Stimulates phospholipase C. SGTC_3137 9097352 49.47 µM -0.233167812916289 0.414322903142316 no 1996 0.407815549309007 654 44120435 SGTC_324 1315-0088 19.6 µM -0.233641929124755 0.414178660762073 no 1997 0.407631486878146 670 6787421 SGTC_873 0591-4978 488 µM -0.233647215069177 0.414177052662045 no 1998 0.407629434872095 641 3305145 SGTC_2207 7258803 200 µM -0.233711163464839 0.414157598273949 no 1999 0.40760461027636 660 3666799 SGTC_1379 2144-0755 36.5 µM -0.235482486281932 0.413618810130913 no 2000 0.406917135315119 656 5392327 SGTC_2469 5655019 90.81 µM -0.236264959263698 0.413380854883683 no 2001 0.406613537870097 667 2788239 SGTC_63 0099-0242 26.702 µM -0.236410187076385 0.413336693635728 no 2002 0.406557196032777 671 3898502 YLR359W ADE13 SGTC_1024 4507-0395 26 µM -0.23829406462235 0.412763938840865 no 2003 0.405826512262305 637 4201836 SGTC_938 3126-1755 342 µM -0.238689067424614 0.412643869749399 no 2004 0.405673347348894 656 1777771 SGTC_1316 1272-0050 65.9 µM -0.240717693158749 0.412027356938221 no 2005 0.404886962490404 666 7340392 SGTC_842 0271-0008 11.1 µM -0.240801682137547 0.412001836799721 no 2006 0.404854412911282 644 1221709 SGTC_773 4358-1457 44.6 µM -0.240834555862629 0.41199184818552 no 2007 0.40484167301521 693 1186886 SGTC_2922 7999257 32.47 µM -0.241924279266487 0.41166077026632 no 2008 0.404419418354392 634 2988377 SGTC_188 3229-0966 278.469 µM -0.242839870924859 0.411382645363059 no 2009 0.404064723669726 654 5722370 SGTC_1114 scopoletin 1.73284 µM -0.242865409127163 0.411374888383049 no 2010 0.404054831453333 666 5280460 A coumarin with genotoxic properties. SGTC_2625 euphol 100 µM -0.246349252678807 0.410317030827031 no 2011 0.40270594315384 636 6708538 A triterpene alcohol. SGTC_641 4092-0595 30 µM -0.247931632794865 0.409836761274919 no 2012 0.402093652211993 649 786260 SGTC_563 tetrahydrosecaminediol 614 µM -0.248055652182788 0.409799125749545 no 2013 0.402045673905992 666 334274 A psychoactive constituent of the cannabis plant. SGTC_2694 st077685 81.9 µM -0.250115907974011 0.409174032356941 no 2014 0.401248857048481 637 2838096 SGTC_1219 1469-0211 33.1 µM -0.251720289130626 0.408687413756567 no 2015 0.400628636704007 684 6822282 SGTC_2176 5809774 33.9695 µM -0.252842298183233 0.408347185140722 no 2016 0.400195040087671 667 2870539 SGTC_2689 tacrolimus 100 µM -0.253657457124361 0.408100046487315 no 2017 0.399880101769401 662 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2167 5876490 200 µM -0.253825635271113 0.408049063037142 no 2018 0.399815133895862 662 686534 SGTC_1215 3852-0577 11.2 µM -0.254170330193528 0.407944573135423 no 2019 0.399681985572841 640 2884876 SGTC_1433 4060-0023 7.6 µM -0.2546727611617 0.407792279276605 no 2020 0.399487928064627 643 3840627 SGTC_1473 k844-0725 134 µM -0.25486815468803 0.40773305652523 no 2021 0.399412466527765 634 54682906 SGTC_1125 tnp00248 1.32998 µM -0.254911147758991 0.407720025834222 no 2022 0.399395862985504 669 24207736 SGTC_2321 7390090 138.78 µM -0.255988980974671 0.407393380739717 no 2023 0.398979672906363 686 649046 SGTC_1806 st050005 60.3 µM -0.256652431907232 0.407192349168926 no 2024 0.398723547755395 659 5194765 SGTC_774 k060-0086 136 µM -0.257204539974952 0.407025074115856 no 2025 0.398510439743887 715 5911235 SGTC_1329 1447-1697 50.6 µM -0.258061696503215 0.406765410554819 no 2026 0.3981796461574 659 2840515 SGTC_21 0849-0113 22.993 µM -0.258203679351778 0.406722402793691 no 2027 0.398124859236856 655 1560156 SGTC_3084 9116877 49.47 µM -0.258233700206683 0.406713309376317 no 2028 0.398113275347032 661 27241325 SGTC_2255 7941087 197.44 µM -0.258853750381782 0.406525505359031 no 2029 0.397874041999469 672 935561 SGTC_2016 5121758 140 µM -0.259639516665239 0.406287539276627 no 2030 0.397570925737973 689 2795203 SGTC_2011 4012611 177 µM -0.261544986672252 0.405710619428811 no 2031 0.396836131034687 677 2049887 SGTC_292 k038-0015 474 µM -0.262497971755962 0.40542216051419 no 2032 0.396468774428461 688 46368540 SGTC_1472 k841-0093 193 µM -0.264159634047737 0.40491931514118 no 2033 0.395828456964121 687 X1472 SGTC_1841 st054148 70 µM -0.264322276050627 0.404870105510537 no 2034 0.395765798341173 697 675442 SGTC_2196 6573537 42.6665 µM -0.264888935599256 0.404698666432323 no 2035 0.395547511044219 688 2903087 SGTC_2407 paclitaxel 400 µM -0.266218092674754 0.404296610629386 no 2036 0.395035624858703 735 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1207 2099-0101 141 µM -0.267633757191875 0.403868498391241 no 2037 0.394490622028444 698 5837381 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.270201482114199 0.403092284766056 no 2038 0.393502626264273 646 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.270571344999941 0.402980507981072 no 2039 0.393360368676446 648 688664 SGTC_8 0354-0001 70 µM -0.27125065742034 0.40277523267397 no 2040 0.39309912693167 666 4993152 SGTC_693 4161-2696 114 µM -0.271532973926916 0.402689929869059 no 2041 0.392990571220282 665 805759 SGTC_72 0744-0168 198.391 µM -0.271713202917412 0.40263547554494 no 2042 0.392921274323463 713 677577 SGTC_2532 xanthone 78.9 µM -0.272275607183466 0.402465563065163 no 2043 0.392705055297651 686 7020 An insecticide. SGTC_1392 3455-1037 33.9 µM -0.272974405872438 0.402254469039917 no 2044 0.392436444910977 663 981132 SGTC_667 1498-1044 59 µM -0.274615867925649 0.401758726244122 no 2045 0.391805687022478 665 6739982 SGTC_635 k038-0028 24.7 µM -0.278687468211503 0.400529734031637 no 2046 0.390242340283182 690 4035102 SGTC_2277 7947813 106.88 µM -0.278739375530797 0.400514072394015 no 2047 0.390222421150961 700 1246798 SGTC_2709 st078560 56 µM -0.279119652839065 0.400399338823063 no 2048 0.390076500736088 690 17250903 SGTC_2602 kawain 100 µM -0.279159978698454 0.400387172600801 no 2049 0.390061027762172 673 5369129 SGTC_1727 st034309 9.9045 µM -0.279763032513292 0.400205244140253 no 2050 0.389829657678077 706 870305 SGTC_1497 4476-2978 41.3 µM -0.281939190985397 0.399548923913728 no 2051 0.388995068965152 651 1528379 SGTC_2376 9072922 81.32 µM -0.281964994118392 0.399541143496128 no 2052 0.38898517614859 711 17087968 SGTC_83 0170-0301 39.027 µM -0.283340409521626 0.399126472362014 no 2053 0.388457951785021 658 3089716 SGTC_1377 2944-0135 198 µM -0.283351895736098 0.399123009885585 no 2054 0.388453549751842 683 1894137 SGTC_2391 6285546 200 µM -0.284222277024596 0.398860659804771 no 2055 0.388120022271811 659 846083 SGTC_1263 0774-1208 64.8 µM -0.285250764027846 0.398550712441479 no 2056 0.387726015516094 693 906585 SGTC_1974 st069448 26.9 µM -0.286039303594852 0.398313119545726 no 2057 0.387424009334635 658 6323587 YNR016C ACC1 SGTC_2379 9035213 200 µM -0.289518492444222 0.397265264985525 no 2058 0.386092315310017 646 646551 SGTC_1851 st056236 18.9 µM -0.290762309601538 0.396890834257225 no 2059 0.38561655652841 666 5393171 SGTC_2458 5808907 16.39 µM -0.292967249708036 0.396227307011743 no 2060 0.38477359241955 704 2731747 SGTC_2219 9098279 200 µM -0.293719529870284 0.396000993832169 no 2061 0.384486114779399 685 902349 SGTC_975 1335-0046 28.5 µM -0.294462200630308 0.3957776058894 no 2062 0.384202371594266 712 16486740 SGTC_2737 bleomycin 30.5 nM -0.296768658979748 0.395084064798913 no 2063 0.383321567293432 685 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2800 7887935 81.82 µM -0.297894984316091 0.394745504712989 no 2064 0.382891658099052 709 2961002 SGTC_2026 5148700 152 µM -0.298175771209441 0.394661115856652 no 2065 0.382784506471041 657 79838 SGTC_1837 st055472 66.5 µM -0.298423710677935 0.394586603210505 no 2066 0.382689897269949 682 676091 SGTC_717 1532-0246 73.2 µM -0.299432473653833 0.394283481915147 no 2067 0.382305043859814 685 9561992 SGTC_1340 1486-1359 257 µM -0.299696925483886 0.394204027863561 no 2068 0.382204171991868 672 4309068 SGTC_493 zm226600 134 µM -0.301091866757521 0.393784993329844 no 2069 0.381672221410937 719 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1089 terbinafine 2.25 µM -0.301182656896016 0.393757724607982 no 2070 0.381637606992466 679 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1791 st048313 56.1 µM -0.301784736632595 0.393576903786074 no 2071 0.381408083558589 649 1204976 SGTC_762 1165-0429 115 µM -0.304904893747159 0.392640204684755 no 2072 0.380219294230597 703 5967793 SGTC_651 3253-0966 34.4 µM -0.30769821269655 0.391802152378062 no 2073 0.379155989926148 671 781462 SGTC_121 0557-0495 61.343 µM -0.308358894865199 0.391604007570577 no 2074 0.378904628073378 696 3104427 SGTC_190 3970-0790 3.722 µM -0.308604026915461 0.391530497308147 no 2075 0.378811378628573 684 2832352 SGTC_830 4076-0286 57.8 µM -0.310412969063656 0.390988151188509 no 2076 0.378123466511308 673 6866659 SGTC_2877 9040724 71.43 µM -0.312718310840595 0.390297284797659 no 2077 0.377247341389704 684 6463895 SGTC_1063 disulfiram 1.84 µM -0.314046836703502 0.389899308399819 no 2078 0.376742733175627 675 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_288 1315-0019 35.1 µM -0.314662922642105 0.389714791354623 no 2079 0.376508799316552 680 6811474 SGTC_1285 0929-0069 65.5 µM -0.314830885563838 0.389664490958523 no 2080 0.376445030014852 674 1206237 SGTC_423 5-fluorouracil 457 µM -0.315368071307879 0.389503630627979 no 2081 0.376241103125907 667 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3313 9133968 57.047 µM -0.315410500764864 0.38949092592867 no 2082 0.376224997492255 702 1494643 SGTC_2180 6301957 200 µM -0.31569296284008 0.389406351007495 no 2083 0.376117784299197 695 845462 SGTC_1352 1496-0991 99 µM -0.316327355809721 0.389216419879367 no 2084 0.375877024722217 709 3000039 SGTC_2923 7992654 58.14 µM -0.316586649080925 0.389138797594953 no 2085 0.375778633785879 657 2985126 SGTC_1050 3232-1156 69.3 µM -0.318205981671104 0.388654132831516 no 2086 0.375164347845918 692 700529 SGTC_665 3914-0008 307 µM -0.31828908881951 0.388629263606242 no 2087 0.375132830078256 703 1069549 SGTC_345 1362-0200 395 µM -0.320410353873405 0.387994644854794 no 2088 0.374328638848063 695 1419823 SGTC_2723 salbutamol 83.58 µM -0.321148354804353 0.387773927178686 no 2089 0.374048983810365 708 9884233 β2-adrenoceptor agonist SGTC_2136 5328288 199.296 µM -0.321751908559468 0.387593446247604 no 2090 0.373820324888647 685 262395 SGTC_2781 5567276 71.43 µM -0.32177341668193 0.387587015112706 no 2091 0.373812177263319 714 2853274 SGTC_2790 5423970 71.43 µM -0.325521424315506 0.386466797336209 no 2092 0.372393235271853 689 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1819 st053448 58.6 µM -0.325625785011166 0.386435619130066 no 2093 0.372353750482954 690 2857616 SGTC_597 k018-0003 82.8 µM -0.327450849178242 0.38589049206112 no 2094 0.371663456111449 718 6786234 SGTC_542 3381-0244 89.3 µM -0.327820847499128 0.385780004962974 no 2095 0.371523561788062 718 1112843 SGTC_139 0099-0334 718.624 µM -0.329974843525904 0.385136973405926 no 2096 0.370709485231728 692 97690 SGTC_2921 7974240 10.71 µM -0.331682071909571 0.384627539395464 no 2097 0.370064669795352 722 2979074 YDR527W RBA50 SGTC_612 0302-0167 22.4 µM -0.332737708778731 0.384312638757345 no 2098 0.369666141200811 686 235821 SGTC_2684 capsaicin 100 µM -0.332833847731622 0.384283963918476 no 2099 0.369629853355319 715 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_116 0155-0182 31.788 µM -0.335212129025205 0.383574808962897 no 2100 0.368732536589142 703 771486 SGTC_2797 7859098 81.82 µM -0.337504268074666 0.382891708699627 no 2101 0.367868397622334 688 972681 SGTC_1970 st070122 35.8 µM -0.33798806793202 0.382747573764843 no 2102 0.367686089811925 727 102928 SGTC_117 lucigenin 22.078 µM -0.339894584969709 0.382179737407372 no 2103 0.366967957351542 731 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2367 9070478 135.38 µM -0.34153396792265 0.381691666674903 no 2104 0.366350818858599 665 572802 SGTC_1656 st012921 11 µM -0.34160877768688 0.381669399082211 no 2105 0.36632266528262 708 6732821 SGTC_1247 0448-0043 5.84 µM -0.345469314574608 0.380520819298465 no 2106 0.364870787639721 723 3089013 YGL099W LSG1 SGTC_2910 7948405 25.97 µM -0.345992660041465 0.380365195309032 no 2107 0.36467411545742 692 2971328 SGTC_2190 6049624 200 µM -0.346204017849287 0.380302350638436 no 2108 0.364594697706698 711 2265554 SGTC_676 falcarinol 140 µM -0.346401845800313 0.380243531768574 no 2109 0.364520369068034 736 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3017 9080681 49.47 µM -0.346574698110741 0.380192141006753 no 2110 0.364455428537429 716 16451914 SGTC_1148 3909-7663 27.7 µM -0.347183427362871 0.380011176411926 no 2111 0.364226760232784 733 4084526 SGTC_1751 st044839 27.194 µM -0.348181336959733 0.379714572128218 no 2112 0.363852001440369 691 5291326 SGTC_3197 9113331 49.47 µM -0.351389256555524 0.378761576409912 no 2113 0.362648170599263 706 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3231 9132313 49.47 µM -0.351524284391044 0.378721479005948 no 2114 0.362597528588625 718 4905967 SGTC_1432 4049-0298 68.4 µM -0.351962461887959 0.378591368309627 no 2115 0.362433207259975 715 741646 SGTC_1045 1348-1485 165 µM -0.352825961059789 0.378335004565971 no 2116 0.362109459874267 703 6810614 SGTC_218 alverine citrate 93.75 µM -0.354074735484384 0.377964351426029 no 2117 0.361641437677119 719 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_186 3455-3465 67.277 µM -0.356382833503029 0.377279572564707 no 2118 0.360776941723961 710 755278 SGTC_3135 9127742 49.47 µM -0.356762657762047 0.377166921173567 no 2119 0.360634746906744 684 3643468 SGTC_2865 9030313 51.95 µM -0.35732397390478 0.377000460573141 no 2120 0.360424642250062 685 42562754 SGTC_2687 chenodiol 100 µM -0.357621260230003 0.376912308353117 no 2121 0.360313382911462 682 5702181 A cholesterol synthesis inhibitor. SGTC_2453 5731132 22.18 µM -0.357756156381172 0.376872310663457 no 2122 0.360262901958709 734 1362040 SGTC_1367 1812-0510 76.9 µM -0.358481413566704 0.376657289294974 no 2123 0.359991537374416 692 1142582 YDR527W RBA50 SGTC_1417 3966-0327 90.4 µM -0.358791241691907 0.376565444342958 no 2124 0.359875632574421 710 651118 SGTC_1554 st069299 38.7 µM -0.361000350687404 0.375910782417204 no 2125 0.359049592456302 696 24207999 SGTC_1876 myriocin 605 nM -0.361217358863417 0.375846492009967 no 2126 0.35896848323213 737 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_101 0490-5701 117.494 µM -0.362136505417476 0.375574225724892 no 2127 0.358625012495783 719 4661669 SGTC_1048 3161-0300 24.5 µM -0.363307893832207 0.375227331065791 no 2128 0.358187448608332 677 2165101 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.363636606800452 0.375130004208374 no 2129 0.358064693625702 740 6710655 SGTC_1460 k062-0059 9.15 µM -0.365270085255388 0.374646474366067 no 2130 0.357454903225976 661 1373085 SGTC_954 1189-0853 2.85 µM -0.365336100860426 0.374626937067106 no 2131 0.357430266717042 707 2828194 SGTC_2829 7992743 58.44 µM -0.366572322624918 0.374261137091604 no 2132 0.356969028240408 728 16462845 SGTC_2635 hydroquinidine 100 µM -0.367218838875598 0.374069876957687 no 2133 0.356727894045847 697 442912 An experimental heart treatment. SGTC_353 1988-1175 58.3 µM -0.369053751767995 0.373527220144354 no 2134 0.356043830053826 725 2788357 SGTC_253 dyclonine 31.25 µM -0.37099277677674 0.372954045654378 no 2135 0.355321455861578 698 3180 An oral anasthetic. SGTC_3071 9117417 49.47 µM -0.371529590004214 0.372795413656791 no 2136 0.355121560457529 710 45595590 YGL055W OLE1 SGTC_996 3970-0799 1.8 µM -0.373795890679625 0.372125944274757 no 2137 0.354278088508301 689 6615648 YGL040C HEM2 SGTC_1929 genistein trimethyl ether 50.5 µM -0.374491255143714 0.371920609697068 no 2138 0.354019430732308 680 136420 SGTC_2742 clothiapine 36.27 µM -0.375094938730565 0.371742377152767 no 2139 0.353794930505193 709 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2336 9001819 198.65 µM -0.376069659641474 0.371454656967211 no 2140 0.353432554780942 728 2989602 SGTC_1397 3532-0190 20.1 µM -0.377196054807431 0.371122254699015 no 2141 0.353013955973676 688 5322280 SGTC_813 k007-0158 173 µM -0.377563673067356 0.371013790347068 no 2142 0.352877377582554 703 6523916 SGTC_548 1436-0017 110 µM -0.378326562897958 0.370788735344509 no 2143 0.352594007481453 718 9677137 SGTC_2736 butenafine 14.65 µM -0.379120083046611 0.370554691193886 no 2144 0.352299346730324 706 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_923 1900-2434 73.3 µM -0.379184811663631 0.370535601976766 no 2145 0.352275314722902 752 5910570 SGTC_2162 5663267 200 µM -0.379686827564775 0.370387562512616 no 2146 0.352088949654767 747 6456493 SGTC_2314 7727897 200 µM -0.381746812735659 0.369780294696421 no 2147 0.351324586713641 690 900724 SGTC_2772 vinpocetine 57.06 µM -0.38360927725941 0.36923153380212 no 2148 0.350634031450756 734 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1971 st069429 63.5 µM -0.383787013467558 0.369179179096581 no 2149 0.350568157056815 730 1246522 YGL099W LSG1 SGTC_2472 5377652 49.4 µM -0.384381595798042 0.369004054131562 no 2150 0.350347819598803 739 1610903 SGTC_19 0279-0214 38.434 µM -0.386322571728495 0.368432559329106 no 2151 0.34962889290166 707 3566274 YBR002C RER2 SGTC_1683 st010134 710 nM -0.387730721554494 0.368018130172546 no 2152 0.349107659189217 746 3818134 SGTC_168 3970-0862 530.542 µM -0.388248344547549 0.367865828380665 no 2153 0.348916129911521 711 3135186 SGTC_120 rhodamine 6G 52.259 µM -0.390665828645546 0.36715480005818 no 2154 0.348022130158862 744 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1318 1280-3875 124 µM -0.390750314014989 0.367129959515775 no 2155 0.347990902211436 739 373245 SGTC_1825 st052143 62.6 µM -0.391046339332657 0.367042926001186 no 2156 0.347881491839152 738 674173 SGTC_945 3381-0768 11.3 µM -0.391715990088127 0.366846069209853 no 2157 0.347634036984749 727 1126236 YIL048W NEO1 SGTC_1678 st019265 80.2 µM -0.392992294266605 0.366470971905303 no 2158 0.347162586376154 747 5367020 SGTC_24 0417-1663 219 µM -0.393941327616078 0.366192139958113 no 2159 0.346812178684772 733 4329390 SGTC_1117 retinoic acid 1.10837 µM -0.397412302624559 0.365172948361805 no 2160 0.345531722371495 735 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_647 0140-0236 81 µM -0.39823164967733 0.364932499877106 no 2161 0.345229719046615 719 990837 SGTC_1505 k297-0037 20.6 µM -0.398736764251387 0.364784293622142 no 2162 0.345043587826565 705 4089396 SGTC_1650 st011916 45.8 µM -0.398887184963296 0.364740162409079 no 2163 0.344988166078302 747 242528 SGTC_2831 7999036 19.48 µM -0.39917026109272 0.364657116917962 no 2164 0.344883877132357 752 2988270 SGTC_2620 irigenin 100 µM -0.401510287727759 0.363970871434305 no 2165 0.344022232696354 718 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_367 0335-0881 7.1 µM -0.401569517593608 0.363953507097918 no 2166 0.344000433562766 750 23828853 SGTC_3019 9081971 49.47 µM -0.401766969313871 0.363895622473125 no 2167 0.343927766597983 724 16451803 SGTC_621 3584-0052 32.1 µM -0.402907513587593 0.363561323190837 no 2168 0.343508131863123 741 2273927 SGTC_1140 3229-1848 2.98 µM -0.403770237796274 0.363308523350455 no 2169 0.343190842116465 742 2849525 SGTC_1040 k898-0338 155 µM -0.404752322000831 0.363020820488765 no 2170 0.342829789068552 738 20969351 SGTC_337 1315-0038 354 µM -0.40529704620103 0.362861276127886 no 2171 0.34262958872739 736 1626437 SGTC_1995 st072814 61.1 µM -0.406516226380007 0.362504276531881 no 2172 0.342181668459205 706 5769371 SGTC_3047 9092122 49.47 µM -0.406595044335968 0.36248120121596 no 2173 0.34215271879622 748 17173831 SGTC_3058 9093861 49.47 µM -0.408255058894591 0.361995319504097 no 2174 0.341543214842173 752 17217477 SGTC_266 formosanin C 406 nM -0.408364151157444 0.36196339627498 no 2175 0.34150317411674 711 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1365 1672-3266 55.4 µM -0.408926777201469 0.361798772536115 no 2176 0.341296698756306 737 6415873 SGTC_162 k030-0015 37.8 µM -0.409052173075242 0.361762085330141 no 2177 0.34125068681327 726 1809920 YMR134W ERG29 SGTC_2211 7117706 200 µM -0.41043764398731 0.361356821248158 no 2178 0.34074246838872 727 822771 SGTC_2820 7989630 71.43 µM -0.412987272113412 0.360611436273261 no 2179 0.339807969476932 707 2984098 SGTC_2460 5552655 174.22 µM -0.41506604085 0.360004098794736 no 2180 0.339046779227915 728 5401989 SGTC_1483 3453-0561 55.9 µM -0.416156163917214 0.359685747218498 no 2181 0.3386478671621 745 4546991 SGTC_970 1315-0089 19.5 µM -0.416910349013925 0.359465557463428 no 2182 0.3383719917676 715 6811083 YLR033W RSC58 SGTC_155 k072-0202 43.6 µM -0.417783385172928 0.359210726552415 no 2183 0.338052749839368 749 5857737 SGTC_1980 st071811 45.7 µM -0.417939066992508 0.359165291093012 no 2184 0.337995834108382 754 4974850 SGTC_2150 5556613 200 µM -0.418311461395521 0.359056616537035 no 2185 0.337859705429108 728 743190 SGTC_449 xestospongin c 11.1929 µM -0.420796989751378 0.358331565966399 no 2186 0.336951664989539 743 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2117 5521686 200 µM -0.421571131782706 0.358105846035131 no 2187 0.336669040591842 720 803312 SGTC_1428 4049-0204 61.7 µM -0.421797687600645 0.358039797554242 no 2188 0.336586346848381 743 X1428 SGTC_2085 5307070 144.047 µM -0.422519743744344 0.357829322770467 no 2189 0.336322846324654 752 2840351 SGTC_1631 benzylvanillin 81.9 µM -0.423723989708158 0.357478388882262 no 2190 0.335883558755332 728 75506 SGTC_2840 9008771 71.43 µM -0.425831129664801 0.356864629214291 no 2191 0.335115450897039 704 2992978 SGTC_906 1165-0455 526 µM -0.43036279043453 0.355545920759098 no 2192 0.333465879074927 761 3252859 SGTC_1408 3909-7976 48.8 µM -0.43063373972382 0.355467129376128 no 2193 0.333367352257904 717 24152374 SGTC_2988 9073640 71.4286 µM -0.430860809396657 0.355401102834051 no 2194 0.333284790486541 756 9102229 SGTC_368 fentichlor 4.58 µM -0.43187377766514 0.355106608276698 no 2195 0.33291657705742 772 7329 A pesticide. SGTC_2977 9011197 71.43 µM -0.43567544070567 0.354002145205503 no 2196 0.331536113456617 769 2704722 SGTC_567 1080-0542 68.4 µM -0.437140594896988 0.353576814222884 no 2197 0.331004694247213 710 5950415 SGTC_1663 st014140 55.4 µM -0.437647248436535 0.353429776331062 no 2198 0.330821007443634 722 4207120 SGTC_2764 methyldopa 94.69 µM -0.438196263879367 0.353270469118027 no 2199 0.330622008345142 762 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2240 6690706 185.951 µM -0.438669724509874 0.353133106205114 no 2200 0.330450433690228 700 805876 SGTC_3190 9110366 49.47 µM -0.439820938115337 0.352799189855202 no 2201 0.330033400769323 737 17123768 SGTC_3330 9141424 71.43 µM -0.44126761158674 0.352379734369796 no 2202 0.329509635403121 716 27261020 SGTC_2788 5282734 71.43 µM -0.442091955001184 0.352140800501081 no 2203 0.329211332883911 769 743706 SGTC_3252 9135871 49.47 µM -0.443389334196066 0.351764876626066 no 2204 0.328742074624854 747 17682838 SGTC_1289 0976-0073 69.1 µM -0.443435858830859 0.351751398505999 no 2205 0.328725251808956 760 3391136 SGTC_646 4092-0839 27.3 µM -0.44416454942258 0.351540322207497 no 2206 0.328461810303678 748 877796 SGTC_2591 skatole 100 µM -0.445330503922927 0.351202680998661 no 2207 0.328040463361806 766 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_648 0375-0473 33.3 µM -0.445413742631825 0.351178580927621 no 2208 0.328010391323103 740 1713139 SGTC_2697 mebhydrolin 72.4 µM -0.447364848885792 0.350613849503189 no 2209 0.327305825726036 725 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1632 st005650 90 µM -0.44982615767013 0.34990191498842 no 2210 0.3264178975863 724 2759605 SGTC_1156 4092-0367 4.88 µM -0.450961069646148 0.349573818749715 no 2211 0.326008803735761 749 1357585 SGTC_1747 st037496 66.6 µM -0.451449102422772 0.349432765928783 no 2212 0.32583295027958 733 723305 SGTC_192 3455-0609 60.9 µM -0.45326626596463 0.348907746361083 no 2213 0.325178510421662 731 3769639 SGTC_2487 5918373 44.05 µM -0.453504979033639 0.348838798232089 no 2214 0.325092579435622 755 2876279 SGTC_1137 ixabepilone 100 µM -0.453999588001244 0.348695954899206 no 2215 0.324914561665537 721 154225 A novel microtubule stabilizer. SGTC_105 0111-0055 734.78 µM -0.455722588542067 0.348198519025689 no 2216 0.324294738255907 755 5179370 SGTC_1730 st033808 45.1 µM -0.455964793714292 0.348128614510117 no 2217 0.324207647572347 759 1045166 SGTC_460 trequinsin 123 µM -0.45605071267145 0.348103818083405 no 2218 0.324176755659658 737 5537 A vasodilator. SGTC_3100 9120536 49.47 µM -0.45616298889654 0.348071415861817 no 2219 0.324136388891862 753 16421196 SGTC_3209 9113616 49.47 µM -0.457050678582926 0.34781527319769 no 2220 0.323817309876188 768 16649353 SGTC_2843 9000894 45.46 µM -0.457146094085895 0.347787745206415 no 2221 0.323783020585888 715 2242070 SGTC_1001 4048-4355 44.4 µM -0.458563171258898 0.34737900377442 no 2222 0.323273944407199 757 21824233 SGTC_1218 1348-1416 30.7 µM -0.462789958962698 0.346160885466614 no 2223 0.321757464607028 739 6787668 SGTC_2932 9016711 44.54 µM -0.465065957327561 0.345505623003536 no 2224 0.320942111891787 765 7117328 SGTC_619 1652-1634 108 µM -0.46608799999767 0.345211526196015 no 2225 0.320576256192051 759 5400454 SGTC_1659 st012954 42.1 µM -0.467162339310888 0.344902481568401 no 2226 0.320191867959559 766 24207262 SGTC_3202 9113761 49.47 µM -0.467164306728572 0.344901915715529 no 2227 0.320191164213328 759 4798415 SGTC_3297 9117502 71.43 µM -0.46907852051483 0.344351529453517 no 2228 0.319506755837283 742 7453720 SGTC_1344 1488-0097 29.1 µM -0.472412828618113 0.343393616379438 no 2229 0.318316074668961 767 747966 SGTC_2721 ifenprodil 61.44 µM -0.472470632806771 0.343377018665372 no 2230 0.31829544929397 728 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2248 tofa 1.1 µM -0.474502734997194 0.34279371935567 no 2231 0.317570724048407 763 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2833 9001315 45.46 µM -0.476004118716558 0.34236299921089 no 2232 0.317035721812764 722 2989378 SGTC_447 ml7 120 µM -0.477401530272698 0.341962290951295 no 2233 0.316538112364801 757 4216 Selective myosin light chain kinase inhibitor. SGTC_2875 9039966 71.43 µM -0.477591294830207 0.341907889610371 no 2234 0.316470563977742 752 6463691 SGTC_58 0957-0393 9 µM -0.478938339626571 0.341521815783109 no 2235 0.31599124743352 751 6997992 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.479161253969448 0.341457942721089 no 2236 0.315911958013999 752 5357218 A potent inhibitor of glutathione S-transferases. SGTC_153 4077-0274 519.67 µM -0.481483089768868 0.340792922614269 no 2237 0.31508659769259 698 3121976 SGTC_422 cantharidin 155 µM -0.484275511860604 0.339993772249482 no 2238 0.314095176323791 745 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_767 0929-0023 86 µM -0.484787932660342 0.339847202816669 no 2239 0.313913391786366 756 1204563 SGTC_1437 4092-1038 11.6 µM -0.48626516369847 0.33942480104131 no 2240 0.313389587520021 763 3977136 SGTC_3170 9103054 49.47 µM -0.487380744091193 0.339105943838001 no 2241 0.312994268449197 776 16432970 SGTC_1462 k081-0014 26.5 µM -0.489780983184736 0.338420293998702 no 2242 0.312144444433599 756 3270634 SGTC_468 gf-109203x 121 µM -0.490243101629989 0.338288347105337 no 2243 0.311980942176944 740 2396 A protein kinase C inhibitor. SGTC_1221 2958-7315 257 µM -0.491922570331052 0.337808982212871 no 2244 0.311387040977439 755 4562705 SGTC_2729 fluphenazine 10.66 µM -0.493869132817411 0.337253710703507 no 2245 0.310699302630811 766 3372 An atypical antipsychotic. SGTC_936 3005-4620 401 µM -0.496632758501181 0.336465974602942 no 2246 0.309724023978712 780 777207 SGTC_3284 9108171 64.8615 µM -0.49717219264999 0.336312299363297 no 2247 0.309533814470373 765 8687505 SGTC_505 gw-5074 63.9 µM -0.500362151284332 0.335404096332488 no 2248 0.308410049361475 748 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1395 3486-0190 4.35 µM -0.501038872949007 0.335211552431195 no 2249 0.30817188262329 777 6748079 SGTC_521 r062-0005 13.8 µM -0.501373700592893 0.33511630176336 no 2250 0.308054072583393 753 2832033 SGTC_2965 9082772 38.63 µM -0.503351245297479 0.334553952743743 no 2251 0.307358671606848 726 16459634 SGTC_2699 st077704 54.6 µM -0.504446204092738 0.334242741761206 no 2252 0.306973928260629 760 645852 SGTC_2249 haloperidol 116.36 µM -0.504824326537815 0.334135297629761 no 2253 0.306841114060662 775 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_7 0192-1582 4.227 µM -0.505983605201591 0.333805971381126 no 2254 0.306434079503102 780 252616 SGTC_2118 5526350 200 µM -0.507082181955375 0.333494007336177 no 2255 0.30604857826522 766 743594 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.507225483411924 0.333453322347174 no 2256 0.305998308215827 782 756377 SGTC_3136 9095672 49.47 µM -0.50800120947063 0.333233118502052 no 2257 0.305726247507392 751 17217380 SGTC_2504 purpurogallin 52.29 µM -0.508006073168539 0.333231738034828 no 2258 0.305724542061406 725 5281571 An antioxidant. SGTC_70 0141-0289 43.283 µM -0.50925367034221 0.332877706205309 no 2259 0.305287213851848 754 352408 SGTC_2198 6589944 200 µM -0.509377843723032 0.33284247755223 no 2260 0.305243701753709 743 5290268 SGTC_1310 1188-0297 994 nM -0.509981068267896 0.332671360519194 no 2261 0.305032362561538 762 1588352 SGTC_86 0417-1630 471.922 µM -0.510223454274339 0.332602612564003 no 2262 0.304947461140595 771 3634867 SGTC_2079 5212404 121 µM -0.510373441380175 0.332560074532997 no 2263 0.304894929874212 760 758462 SGTC_1411 3909-8223 150 µM -0.511492216648834 0.332242845329388 no 2264 0.304503218567413 783 X1411 SGTC_2192 5915882 198.485 µM -0.511540912619449 0.332229040293516 no 2265 0.304486173972211 761 2876149 SGTC_420 mitomycin C 81.9 mM -0.513977431933784 0.331538591667391 no 2266 0.303633884615752 745 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_54 0159-0055 9 µM -0.514241313964517 0.331463848391415 no 2267 0.303541643184636 802 3319099 SGTC_531 3788-1495 174 µM -0.514434167098073 0.331409227942777 no 2268 0.30347423821537 729 2896655 SGTC_1044 1222-0021 1.78 µM -0.51586595148542 0.331003825827805 no 2269 0.302974018025641 777 4306703 SGTC_2866 9034245 58.44 µM -0.515973125672931 0.330973487990093 no 2270 0.302936589601752 751 6462273 SGTC_941 3237-0776 460 µM -0.516061197773901 0.330948558217974 no 2271 0.302905833745628 780 760008 SGTC_2675 theaflavin digallate 100 µM -0.518745288740108 0.330189156861047 no 2272 0.301969187587245 771 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1149 3909-7961 23.3 µM -0.520918497378094 0.329574809709404 no 2273 0.301211774560879 738 735261 SGTC_2860 9025725 38.96 µM -0.521543548316166 0.329398198292525 no 2274 0.300994088548865 785 40546248 SGTC_1784 st039334 36.3 µM -0.521741324459067 0.32934232353074 no 2275 0.300925223976984 790 3496984 SGTC_3182 9108849 49.47 µM -0.522816844451055 0.329038539548646 no 2276 0.300550858231819 755 17133045 SGTC_1172 0370-0043 85 µM -0.525093799562707 0.328395779087893 no 2277 0.299758993113303 760 376585 SGTC_3232 9132874 49.47 µM -0.525139565021283 0.328382865178021 no 2278 0.299743086780352 769 3784940 SGTC_1640 st009078 66.4 µM -0.525430647345587 0.328300733558474 no 2279 0.29964192658313 766 690618 SGTC_3141 9094609 49.47 µM -0.527357940102598 0.327757139273858 no 2280 0.298972522787288 774 25236309 YDL196W YDL196W SGTC_1235 benzylparaben 21.5 µM -0.53012964027054 0.326976019028798 no 2281 0.298011024841756 786 7180 SGTC_1270 0831-1170 17.3 µM -0.530747561134656 0.326801979774477 no 2282 0.297796861436744 772 6764716 SGTC_1286 0929-0070 131 µM -0.5315374696948 0.326579554538439 no 2283 0.297523191586326 782 1420408 SGTC_2406 ethylparaben 405.7 µM -0.533764565436427 0.325952773133397 no 2284 0.296752216219707 771 8434 A possible steroid mimic. SGTC_847 0342-0274 5.54 µM -0.535094693669456 0.325578663565314 no 2285 0.296292189519357 762 18097 SGTC_3057 9095946 49.47 µM -0.536494346010464 0.325185189398158 no 2286 0.295808471234212 785 24540043 SGTC_2409 alverine citrate 63.97 µM -0.53950288369165 0.324340080857556 no 2287 0.294769953870139 731 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1897 st060201 15 µM -0.540922465077674 0.323941629222277 no 2288 0.294280512906574 768 611878 SGTC_593 1203-0218 61.7 µM -0.542178443151702 0.323589266269974 no 2289 0.293847792043082 789 3666956 SGTC_1657 st012939 43.4 µM -0.542582198431747 0.3234760268395 no 2290 0.293708749186302 784 24207257 SGTC_3241 9133421 49.47 µM -0.542853244352285 0.323400016977106 no 2291 0.293615425079205 789 17018221 SGTC_2861 9024595 19.48 µM -0.543844025654522 0.323122233239795 no 2292 0.29327440498786 747 16482810 SGTC_1031 k035-0009 16 µM -0.544788909466528 0.322857409563161 no 2293 0.292949353627454 794 5180959 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.54540228513422 0.322685546114282 no 2294 0.292738434572588 780 616764 SGTC_683 panaxydol 45 µM -0.547040691157771 0.322226662298812 no 2295 0.292175388452867 764 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1913 st060213 96.1 µM -0.548477180117106 0.321824554069376 no 2296 0.291682147070607 790 688959 SGTC_2342 7990637 118.86 µM -0.548815584367114 0.321729856820023 no 2297 0.291566007086411 811 2033102 YER133W GLC7 SGTC_1764 st044502 93.5 µM -0.549835316826758 0.321444570340941 no 2298 0.291216166428183 767 8407 SGTC_1434 4073-0095 163 µM -0.550893962671638 0.321148508612424 no 2299 0.290853183181261 787 24133745 SGTC_351 caspofungin 25 nM -0.551721626331978 0.320917122684658 no 2300 0.290569545353682 770 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2480 5767542 37.17 µM -0.551727341186761 0.320915525251965 no 2301 0.290567587340256 767 2867358 SGTC_62 0180-0423 3.232 µM -0.55413347756701 0.32024324991033 no 2302 0.289743750205124 803 30102 YGL099W LSG1 SGTC_815 1582-0027 36.9 µM -0.55451217952546 0.320137494098007 no 2303 0.289614186321423 784 3128206 SGTC_3226 9131256 49.47 µM -0.554747904641679 0.320071673188381 no 2304 0.289533552306023 766 17178073 SGTC_1296 1068-0102 11.9 µM -0.556147098774343 0.319681096478168 no 2305 0.289055149926206 778 767053 SGTC_1534 6-azauridine 81.6 µM -0.556345530032907 0.319625721748341 no 2306 0.288987333853989 772 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_141 0443-0274 32.331 µM -0.556346559966792 0.319625434342869 no 2307 0.288986981882246 763 1627241 SGTC_2853 9015042 58.44 µM -0.561002076912375 0.31832741053832 no 2308 0.287398060667309 770 6457456 SGTC_539 4859-0462 2.54 µM -0.56139271928362 0.318218595007876 no 2309 0.287264923132194 769 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2393 9031399 185.94 µM -0.561868775868558 0.318086008095238 no 2310 0.287102714455329 798 1526623 YDL150W RPC53 SGTC_1799 st045822 46.1415 µM -0.561894525373281 0.318078837243762 no 2311 0.287093941959395 796 3674992 SGTC_723 4182-0001 115 µM -0.562276031630232 0.317972601455554 no 2312 0.286963982989557 787 744821 YLR208W SEC13 SGTC_2221 6807166 181.081 µM -0.562530482779508 0.317901754276316 no 2313 0.286877320458484 780 674925 SGTC_2159 5658611 73.75 µM -0.564119818924725 0.31745938416354 no 2314 0.286336295467708 784 793844 SGTC_1421 4029-0249 71.4 µM -0.565571781674037 0.317055477794797 no 2315 0.285842457452867 795 2894095 SGTC_1552 6-methylflavone 10.6 µM -0.566488607936996 0.316800547648692 no 2316 0.285530837500429 803 689013 SGTC_940 3232-1287 54.8 µM -0.567985394923586 0.316384542169818 no 2317 0.285022442565573 800 1585493 YIL048W NEO1 SGTC_2622 2-methoxyxanthone 59.94 µM -0.568658796615238 0.316197457789219 no 2318 0.284793857488277 775 71034 A hepatoprotective. SGTC_2025 5147754 141 µM -0.568714255105006 0.316182052414102 no 2319 0.284775036096316 771 315777 YLR208W SEC13 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.569704878238247 0.315906928827951 no 2320 0.284438940428058 770 6708784 An antioxidant flavonoid SGTC_2156 5649887 115 µM -0.571707347595701 0.315351098843571 no 2321 0.283760127894718 773 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1774 st048371 48.465 µM -0.572434547518448 0.315149351606328 no 2322 0.283513808190187 794 4242727 SGTC_1557 sumaresinolic acid 42.3 µM -0.572682515363639 0.315080570431324 no 2323 0.283429839087134 770 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2769 toremifene 3.73 µM -0.573138024454776 0.314954238294399 no 2324 0.283275621571137 777 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1265 0819-1001 68.8 µM -0.573568580076361 0.314834846720567 no 2325 0.283129889329754 778 3106768 SGTC_3291 9121177 71.43 µM -0.577847010240035 0.313649506089855 no 2326 0.281683706748345 788 17015612 SGTC_736 0958-0254 92.6 µM -0.578900663403841 0.313357885474324 no 2327 0.281328101274495 812 6812352 SGTC_1242 0402-0103 60.1 µM -0.578931003038353 0.313349490071069 no 2328 0.281317864929485 793 432868 SGTC_206 4546-0025 72.014 µM -0.579907672244729 0.313079283666116 no 2329 0.280988440799406 821 6620745 YIL048W NEO1 SGTC_1999 st074831 12.5 µM -0.580205568461836 0.312996887328276 no 2330 0.280887999468593 813 17112523 SGTC_425 3825-7017 13.1 µM -0.581070992147721 0.312757569224211 no 2331 0.280596304030674 790 3397440 SGTC_1100 amiodarone 5.07 µM -0.581987499060189 0.312504210954835 no 2332 0.28028755062408 766 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_339 3091-4833 71.4 µM -0.586284482198333 0.311317540113738 no 2333 0.27884217864576 791 3240077 SGTC_2131 toluylene red 5.2905 µM -0.587105643094198 0.311090987737404 no 2334 0.27856637892143 757 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1261 0712-0010 12.7 µM -0.588145291415833 0.310804258911768 no 2335 0.278217387488263 794 2840123 SGTC_3103 9120822 49.47 µM -0.588760043626921 0.310634767929439 no 2336 0.27801112646635 812 17141819 SGTC_2302 7771753 200 µM -0.590806299892025 0.310070892089696 no 2337 0.277325106694945 778 2203047 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.591340646759559 0.309923718441705 no 2338 0.277146100086047 780 803109 SGTC_2335 9018011 154.17 µM -0.592247240498443 0.309674087565541 no 2339 0.27684251988149 771 6458208 SGTC_1958 st076513 41.9 µM -0.593301417054339 0.309383930068369 no 2340 0.276489725302004 796 732122 YGL099W LSG1 SGTC_77 0828-0286 12.516 µM -0.594143710635453 0.30915217781243 no 2341 0.276207998777013 789 745345 SGTC_1323 1348-1351 11.2 µM -0.596356113869619 0.308543809527254 no 2342 0.275468675892747 797 6989654 SGTC_894 0960-0238 55.9 µM -0.596838479048763 0.308411238075569 no 2343 0.275307612383633 808 6741907 YDL195W SEC31 SGTC_396 dithiazanine 1.25 µM -0.59731965443286 0.308279018508191 no 2344 0.27514699234261 785 10578 An antihelmenthic. SGTC_530 4358-1714 28 µM -0.597872533262689 0.308127126645361 no 2345 0.274962494129905 793 1564641 SGTC_2815 7968870 71.43 µM -0.598311136224097 0.308006653049318 no 2346 0.274816173672787 797 2977326 YHR190W ERG9 SGTC_600 1495-0418 41.6 µM -0.600306652263501 0.307458794514161 no 2347 0.274150943072861 794 5377768 SGTC_1771 st048882 4.1505 µM -0.600741050212038 0.307339589671521 no 2348 0.274006236499531 781 4580403 SGTC_147 4466-0538 29.23 µM -0.601078826258108 0.307246913286445 no 2349 0.273893742691871 801 6742687 YHR072W ERG7 SGTC_2070 5230947 200 µM -0.60141653072586 0.307154268844984 no 2350 0.273781295552882 817 2835538 SGTC_1672 st016598 6.51 µM -0.60183804298248 0.307038650191994 no 2351 0.273640974557603 806 4665860 YNL267W PIK1 SGTC_414 piperonyl butoxide 100 µM -0.603674107519992 0.306535250998019 no 2352 0.273030165955887 801 5794 A potent inhibitor of cytochrome P450. SGTC_2924 9010168 62.78 µM -0.606045444134611 0.305885634586187 no 2353 0.272242288400218 791 2993929 SGTC_275 trichlorophene 5.69 µM -0.608089174275979 0.305326253853799 no 2354 0.271564165923481 796 62616 SGTC_318 1488-0629 67.2 µM -0.60933674258148 0.304985010415535 no 2355 0.271150628806607 820 3662576 SGTC_2332 7982454 138.89 µM -0.61355019826244 0.303833771467428 no 2356 0.269756300801136 822 2981748 SGTC_2540 epiandrosterone 100 µM -0.61379263292286 0.30376759026444 no 2357 0.269676183053773 818 441302 A steroid. SGTC_1197 1601-0112 267 µM -0.6139356767506 0.303728544358086 no 2358 0.269628916736333 809 7350313 SGTC_1467 k284-1082 293 µM -0.614333086140148 0.303620077405988 no 2359 0.269497621578662 811 3334705 SGTC_2522 biochanin a 4.94 µM -0.614650057407998 0.303533577236037 no 2360 0.269392924349773 798 5280373 A possible chelator. SGTC_1684 st024538 14.6195 µM -0.614754623590443 0.30350504396448 no 2361 0.269358390079281 798 6732859 SGTC_2270 7924575 90.91 µM -0.622517341871448 0.301390164283175 no 2362 0.26680087211206 805 1262135 SGTC_2708 st078559 56 µM -0.625636739813473 0.300542186172601 no 2363 0.265776617481145 790 17250902 SGTC_2973 9094665 17.96 µM -0.62596591298025 0.300452766512968 no 2364 0.265668649817773 821 25237061 YIL048W NEO1 SGTC_1690 st023502 41.2 µM -0.626109318307323 0.3004138143152 no 2365 0.265621620321083 812 24207482 SGTC_3025 9087895 49.47 µM -0.626204650423236 0.300387921174022 no 2366 0.265590358676483 806 17173641 SGTC_2360 9040895 200 µM -0.626520992093061 0.300302006887935 no 2367 0.265486636169047 795 4914414 SGTC_2621 lithochol-11-enic acid 100 µM -0.629143549330748 0.299590182534348 no 2368 0.264627540937799 829 6708711 SGTC_2456 5770359 74.46 µM -0.630801716177469 0.299140511566455 no 2369 0.264085090566021 830 3118787 SGTC_2351 9026858 72.31 µM -0.631821856842956 0.298864016411772 no 2370 0.263751644890889 824 1409300 SGTC_1312 1218-2183 165 µM -0.632280292000371 0.298739801667566 no 2371 0.263601869610567 817 6744073 SGTC_574 1315-0397 40 µM -0.632370055268294 0.298715482717326 no 2372 0.263572548148183 824 6794277 SGTC_2955 9076254 12.21 µM -0.63290904902697 0.298569475742579 no 2373 0.263396519096208 798 16459619 SGTC_3266 9136860 49.47 µM -0.633412118428562 0.298433229541168 no 2374 0.26323227668822 800 4871271 YPR165W RHO1 SGTC_2173 5763948 167 µM -0.634874162038848 0.298037425205823 no 2375 0.26275524490438 806 2867177 SGTC_93 0109-0045 59.227 µM -0.635714887875756 0.297809932357676 no 2376 0.26248113545065 818 88733 SGTC_3059 1327-0034 3 µM -0.636918332601443 0.29748442893723 no 2377 0.262089020379781 799 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_807 1315-0151 48 µM -0.636967336096353 0.297471178090208 no 2378 0.262073060070029 831 4011080 SGTC_1972 st070201 17.4 µM -0.636975310342333 0.29746902183045 no 2379 0.262070462926159 805 2829099 SGTC_1723 st034307 2.5525 µM -0.639177394855056 0.296873844988003 no 2380 0.261353767954031 829 867466 SGTC_1435 4092-0789 56.7 µM -0.639996450232965 0.296652610778657 no 2381 0.261087453589482 822 2248285 SGTC_1267 0828-0272 9.49 µM -0.640138728311105 0.296614187891356 no 2382 0.261041206355967 810 745334 SGTC_627 1391-0720 175 µM -0.64169651560004 0.296193649050641 no 2383 0.260535126033381 840 997839 SGTC_315 k915-0449 187 µM -0.643070015098313 0.29582308743165 no 2384 0.26008933494478 812 20970215 YNL149C PGA2 SGTC_3092 9117248 49.47 µM -0.64458392751162 0.295414890184751 no 2385 0.25959842661587 836 17141857 SGTC_918 glabranin 770.725 nM -0.646071852466228 0.29501395261636 no 2386 0.259116411656043 798 124049 Also referred to as licorice root. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.646144430671041 0.294994402042984 no 2387 0.259092911706619 839 688798 SGTC_219 mitoxanthrone 164.414 µM -0.646698078073019 0.294845284298948 no 2388 0.258913683612064 828 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3353 9151644 39.2805 µM -0.648404008120714 0.294386032790792 no 2389 0.258361839311005 805 4909158 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.648710048478359 0.294303678962638 no 2390 0.2582629040867 805 6312947 SGTC_158 k038-0087 26.446 µM -0.649923463940861 0.293977260105289 no 2391 0.257870830452337 796 X158 SGTC_3151 9099821 49.47 µM -0.650233095382525 0.293893993485786 no 2392 0.257770833143703 827 17174189 SGTC_2006 4011487 200 µM -0.650699863675958 0.293768489974543 no 2393 0.257620125606963 819 45595294 SGTC_1627 st003713 25.6 µM -0.650701331323985 0.293768095396062 no 2394 0.257619651813142 812 16195070 YER133W GLC7 SGTC_3218 9131285 49.47 µM -0.65180263620272 0.293472077756657 no 2395 0.25726425040649 828 17156417 SGTC_3010 9080089 71.4286 µM -0.654558898267215 0.292731833588401 no 2396 0.256375897177503 805 17027233 SGTC_2939 9044578 71.43 µM -0.656687458460891 0.292160764205929 no 2397 0.255690950119368 823 2653634 SGTC_319 1348-1596 45.5 µM -0.658750582519603 0.29160774586784 no 2398 0.255027972748906 824 5380505 SGTC_2984 9022109 38.96 µM -0.659218426830805 0.291482408584138 no 2399 0.254877757877498 845 6459207 SGTC_2340 7987427 183.45 µM -0.660064734274145 0.291255743438805 no 2400 0.254606144229622 802 2239331 SGTC_2160 5660466 132.927 µM -0.660069084467927 0.291254578546062 no 2401 0.254604748471539 827 2859134 SGTC_564 3555-0129 330 µM -0.665428914909191 0.289820980802169 no 2402 0.252888097955619 819 563260 SGTC_1217 1183-1422 255 µM -0.665887150882367 0.289698569852831 no 2403 0.252741616999118 814 2849664 SGTC_1911 st060208 74.3 µM -0.667173193074733 0.28935515241343 no 2404 0.252330756020116 836 688783 SGTC_527 4476-4215 268 µM -0.668871795623162 0.288901860581291 no 2405 0.251788631598429 808 4418754 SGTC_1084 voriconazole 435 nM -0.670514253274386 0.288463869716539 no 2406 0.251265011720009 841 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1661 st013063 9.66 µM -0.674585288492767 0.287379606293614 no 2407 0.249969641145732 844 721395 SGTC_3189 9110682 49.47 µM -0.674981757254995 0.287274115474586 no 2408 0.249843677628904 828 17122418 SGTC_386 1509-0011 3.07 µM -0.6760547518564 0.286988709315632 no 2409 0.249502941727032 813 3107280 SGTC_1540 guanosine 70.6 µM -0.676350513357125 0.286910063244264 no 2410 0.249409064310348 829 6802 Guanosine is a purine nucleoside SGTC_12 0849-0099 9.267 µM -0.677961403188054 0.286481890189327 no 2411 0.248898082850393 829 6071388 SGTC_377 3970-0964 33.1 µM -0.678147459725221 0.286432456068812 no 2412 0.248839100800955 819 16481235 SGTC_3264 9137442 49.47 µM -0.679925034558597 0.285960369170235 no 2413 0.248275964585556 823 17015726 SGTC_114 0364-0001 490.298 µM -0.685837408190571 0.284392832268402 no 2414 0.246407821960182 831 4003655 SGTC_883 0850-0245 24.6 µM -0.686945284570956 0.284099560411823 no 2415 0.246058604371714 826 6823229 YPR165W RHO1 SGTC_2974 9094440 9.66 µM -0.687118670272536 0.284053675653285 no 2416 0.246003974895258 822 25236134 SGTC_278 4092-0821 23.9 µM -0.68714878746434 0.284045705806861 no 2417 0.245994486388501 830 877900 SGTC_2462 5162487 171.77 µM -0.687467251169343 0.283961438001701 no 2418 0.245894165511354 828 2259986 SGTC_1032 k061-1018 98.7 µM -0.687849883866541 0.283860206440102 no 2419 0.245773659477552 837 4005393 SGTC_2108 5365811 200 µM -0.688846714635385 0.283596560171992 no 2420 0.245459867344624 816 780283 SGTC_2004 4023728 41.89 µM -0.690289396869301 0.283215201001284 no 2421 0.245006107222991 854 360084 YDR527W RBA50 SGTC_2787 5284540 71.43 µM -0.693880346576063 0.282267037659943 no 2422 0.243878624846334 837 736958 SGTC_1834 st055981 52.8 µM -0.694458758094319 0.28211445539302 no 2423 0.243697278020875 825 471719 YDL150W RPC53 SGTC_2103 5378138 10 µM -0.69580296403436 0.281760013575995 no 2424 0.243276116378164 827 244142 SGTC_431 k089-0097 107 µM -0.696615812701749 0.281545784870739 no 2425 0.243021628641805 832 5499420 SGTC_2765 myclobutanil 7.74 µM -0.698022047893761 0.281175353007824 no 2426 0.242581702912795 862 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2166 5933061 31.504 µM -0.698294554498539 0.281103596283915 no 2427 0.242496502028743 843 2877375 SGTC_2777 climbazole 1.536 µM -0.699510324519001 0.280783566266201 no 2428 0.242116581520484 840 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2483 5729050 27.16 µM -0.703714319673034 0.27967829861614 no 2429 0.240805350419107 844 2865180 SGTC_820 1582-0060 59.9 µM -0.70587265644093 0.279111674172202 no 2430 0.240133666663548 845 3848840 SGTC_862 0452-0056 10.2 µM -0.706206134429415 0.279024176575128 no 2431 0.240029978028765 839 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1414 3917-0015 5.4 µM -0.706632667345535 0.278912282772564 no 2432 0.239897391322372 837 6618702 SGTC_1192 1488-0095 21.4 µM -0.706972150649994 0.278823240590131 no 2433 0.239791892329076 857 915875 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.708195125439123 0.278502584484686 no 2434 0.239412046425041 844 2346 DNA damaging agent; causes G2/M arrest. SGTC_1188 1403-0014 4.57 µM -0.708350583710246 0.278461837201205 no 2435 0.239363785916835 833 9614867 SGTC_3168 9103419 49.47 µM -0.708563272335337 0.278406093932866 no 2436 0.23929776741071 840 16649256 SGTC_3212 9128307 49.47 µM -0.708632380281433 0.278387982697186 no 2437 0.239276318459591 838 27243542 SGTC_2856 9022925 19.48 µM -0.712688837773853 0.277325907248856 no 2438 0.238019162580497 826 4944862 SGTC_2531 methyl deoxycholate 70.07 µM -0.712880615706663 0.277275744394578 no 2439 0.237959817541098 846 16667744 Haematoxylin. SGTC_2852 9023854 51.95 µM -0.714415860759332 0.276874334381982 no 2440 0.237485033616312 853 19798528 SGTC_2142 5622915 118.518 µM -0.715975880894087 0.276466738326667 no 2441 0.237003120974056 844 5322196 SGTC_1479 0549-0158 134 µM -0.716809177647401 0.276249138383627 no 2442 0.236745924019916 842 5440202 SGTC_308 4092-1169 104 µM -0.718463745152696 0.2758173281207 no 2443 0.236235697239859 859 2268590 YDL196W YDL196W SGTC_2476 5806916 10.51 µM -0.718781906813996 0.275734332088855 no 2444 0.236137653696085 833 2870194 SGTC_1394 3474-0001 65.7 µM -0.719981889720013 0.275421413610222 no 2445 0.235768073088122 820 5017666 YIL048W NEO1 SGTC_1677 st019204 53.9 µM -0.720416077768693 0.275308233838584 no 2446 0.235634426901839 836 3945625 SGTC_1513 0337-0559 19 µM -0.72149631730481 0.275026747224997 no 2447 0.235302102830176 843 775073 SGTC_149 3970-0822 46.1 µM -0.721977250216758 0.274901472334884 no 2448 0.235154232276482 838 3114250 YBL034C STU1 SGTC_2897 9048598 12.99 µM -0.722644566672709 0.274727694276646 no 2449 0.234949140142179 847 6467404 SGTC_2952 9073731 13.78 µM -0.722807901637299 0.274685167937906 no 2450 0.234898956056848 856 16457353 SGTC_2678 equilin 100 µM -0.722887678385895 0.274664398225201 no 2451 0.234874447088785 813 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_566 0958-0068 16.5 µM -0.723347548814447 0.27454468700593 no 2452 0.234733193511759 842 6815365 SGTC_1373 2887-0003 58.5 µM -0.727072427399523 0.273575994580401 no 2453 0.233590794227598 860 776948 SGTC_2491 paeonol 100 µM -0.727878268716481 0.273366650140146 no 2454 0.233344053497666 852 11092 Increases levels of cortical cytochrome oxidase. SGTC_1502 4534-4282 27.7 µM -0.728627741183095 0.273172020632836 no 2455 0.23311470221414 856 3278949 SGTC_1180 1193-0155 285 µM -0.731747494353431 0.272362594593708 no 2456 0.232161350910909 851 2921347 SGTC_1241 0364-0022 50.8 µM -0.732788562687049 0.272092752756382 no 2457 0.231843699076765 858 4563895 SGTC_473 2-arachidonoylglycerol 10 µM -0.7333739979895 0.271941068065281 no 2458 0.231665176860262 834 5282280 An endocannabinoid. SGTC_2329 6138490 200 µM -0.734120494101603 0.271747713987477 no 2459 0.23143765203503 869 720019 SGTC_1962 st076595 64.5 µM -0.735007489972905 0.271518057280096 no 2460 0.231167466294567 844 279619 SGTC_768 0384-0033 77.3 µM -0.736315652991225 0.271179530508771 no 2461 0.230769311199212 842 3965305 YMR134W ERG29 SGTC_2567 aureobasidin a 60 nM -0.737971311760659 0.270751380629516 no 2462 0.230265941235317 864 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1091 telmisartan 47.6 µM -0.738171239507397 0.270699702580366 no 2463 0.230205198779098 864 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2250 alverine citrate 130 µM -0.740914932498017 0.269991000840812 no 2464 0.229372510435054 830 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_805 3852-0218 479 µM -0.741502988878904 0.269839225543922 no 2465 0.229194260101999 839 6615355 SGTC_3191 9110352 49.47 µM -0.742039235289159 0.269700859466545 no 2466 0.229031782030816 847 17122424 SGTC_2670 beta-carotene 100 µM -0.742490912549489 0.269584342096108 no 2467 0.228894977839639 806 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1244 0416-0015 52.5 µM -0.742690562413742 0.269532847261279 no 2468 0.228834522426651 849 96201 SGTC_594 1487-1584 10.8 µM -0.746586273624857 0.268529030701081 no 2469 0.227656668287448 871 5013332 SGTC_759 3486-0358 89.3 µM -0.748372109197911 0.268069499496534 no 2470 0.227117870396489 861 875103 SGTC_279 1273-0055 2.93 µM -0.748397800540171 0.26806289148997 no 2471 0.227110124404827 875 2847562 SGTC_2589 lobaric acid 100 µM -0.749695393869548 0.267729247415259 no 2472 0.226719091162067 872 73157 A novel microtubule depolymerizer. SGTC_1714 st033236 13.627 µM -0.751144387904256 0.267356921858051 no 2473 0.226282882266127 866 2916566 SGTC_352 k048-0007 5.11 µM -0.754487837067616 0.266498805423228 no 2474 0.22527817303925 886 6811911 SGTC_2935 9038016 29.96 µM -0.756850647877587 0.265893216988822 no 2475 0.224569672673408 865 6463195 SGTC_580 1123-0028 41 µM -0.757064320240537 0.265838487160992 no 2476 0.224505664359662 877 1677248 YPR107C YTH1 SGTC_779 1360-0071 233 µM -0.757939651307271 0.265614340344712 no 2477 0.224243555738943 838 7566 SGTC_1112 tnp00069 1.16933 µM -0.759145035026211 0.265305833599146 no 2478 0.223882900879822 860 145826 SGTC_2034 5197015 53.07 µM -0.76187341545983 0.264608202477296 no 2479 0.223067778990459 861 780676 SGTC_298 1391-0729 10 µM -0.762871512835418 0.264353228067198 no 2480 0.222770013448572 858 3237558 SGTC_631 k072-0230 41.5 µM -0.763093185644674 0.26429661640929 no 2481 0.222703911852304 873 5773147 SGTC_1158 4092-0494 91.8 µM -0.763223446428395 0.264263352787054 no 2482 0.222665074027862 848 1148199 SGTC_2776 terbinafine 19.92 µM -0.763633768977811 0.264158586036956 no 2483 0.222542759796457 843 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2225 6654152 15.4 µM -0.763874379342444 0.264097161366066 no 2484 0.222471053382162 853 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1685 st024049 53.0905 µM -0.765042164975856 0.263799144406305 no 2485 0.22212321852048 856 1941139 SGTC_2435 5706476 10.6 µM -0.766259177797879 0.26348874733132 no 2486 0.22176105146136 833 5725375 SGTC_2346 9031566 143.75 µM -0.766708839239933 0.263374109115499 no 2487 0.221627323507093 861 4771086 SGTC_1871 st057448 67.3 µM -0.767318836054671 0.263218635169805 no 2488 0.221445985980547 868 691747 SGTC_2323 6148992 148.28 µM -0.767606449638366 0.263145345449336 no 2489 0.221360514747201 864 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1422 4031-0024 15.5 µM -0.768182883040778 0.262998490029491 no 2490 0.221189270623171 887 782427 SGTC_2241 6772625 37.8075 µM -0.768877967010199 0.262821462252632 no 2491 0.220982879173025 853 2285411 SGTC_145 3737-0113 38.366 µM -0.772116245335623 0.261997523916299 no 2492 0.220022790660792 850 6849351 SGTC_3096 9117468 49.47 µM -0.774038460676609 0.261509067979906 no 2493 0.219454023733955 850 41316311 SGTC_3077 9117319 49.47 µM -0.77459136666809 0.261368655152964 no 2494 0.219290580185933 874 17154678 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.775403031776498 0.261162599517055 no 2495 0.219050772101933 858 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_888 0916-0002 6.97 µM -0.777613240887666 0.260601922091259 no 2496 0.218398526387499 858 2802138 YIL048W NEO1 SGTC_1642 st009582 77.7 µM -0.778522335245229 0.260371486476481 no 2497 0.218130572312393 872 6739311 SGTC_781 4335-2806 94.4 µM -0.779378326553206 0.260154607312124 no 2498 0.217878443562921 903 845254 SGTC_3185 9108267 49.47 µM -0.781008837877934 0.259741748812674 no 2499 0.217398648360446 864 4910486 SGTC_562 3772-2733 112 µM -0.781074521114265 0.259725124380001 no 2500 0.217379333164278 854 2876874 YIL048W NEO1 SGTC_3300 9124615 50.48 µM -0.781532870512983 0.259609131396533 no 2501 0.217244575848015 867 24824903 SGTC_1969 st069479 40.1 µM -0.782035777921966 0.259481893040527 no 2502 0.217096773754417 866 3895485 SGTC_438 sphingosine 6.67 µM -0.783602836604731 0.259085625165321 no 2503 0.216636595426365 856 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2989 9073649 71.4286 µM -0.783996863644938 0.2589860353564 no 2504 0.216520975316869 869 21367202 SGTC_98 0074-0023 107.663 µM -0.785598504364449 0.258581426707053 no 2505 0.216051370485916 851 3563821 SGTC_3072 9116419 49.47 µM -0.785905160514536 0.258503996166381 no 2506 0.215961525520199 864 17170162 SGTC_2032 5185112 25.99 µM -0.787564214585636 0.258085294086224 no 2507 0.215475826772483 831 5718189 SGTC_3348 9149464 3.537 µM -0.787726139411407 0.258044447318783 no 2508 0.215428456200434 861 1951442 SGTC_2272 7805186 180 µM -0.79059804625109 0.257320544470321 no 2509 0.214589293654855 901 2956062 YPR165W RHO1 SGTC_2388 9080168 200 µM -0.790844032114183 0.257258589525062 no 2510 0.21451750577539 876 15943073 SGTC_1636 st007707 68.9 µM -0.791534776180529 0.257084657535468 no 2511 0.214315995475463 883 403051 SGTC_3114 9122766 49.47 µM -0.792859132167799 0.256751350766079 no 2512 0.213929950065323 836 17176985 SGTC_2570 licareol 100 µM -0.793457601535781 0.256600805054928 no 2513 0.21375563110853 871 443158 SGTC_2278 7948257 134.34 µM -0.793777374405129 0.256520384641772 no 2514 0.213662523298712 852 1247028 SGTC_2958 9077254 16.72 µM -0.79378129233255 0.256519399394633 no 2515 0.213661382667908 872 16457351 SGTC_2814 7977482 42.97 µM -0.7943275365124 0.256382053842691 no 2516 0.213502388686728 859 6456762 SGTC_2960 9079389 5.97 µM -0.794464158788454 0.256347708051078 no 2517 0.213462633151039 874 16457355 SGTC_3204 9114183 49.47 µM -0.794745465995715 0.256276997130882 no 2518 0.213380789527376 867 17027248 SGTC_513 4245-1575 41.7 µM -0.796556795135457 0.255821935146179 no 2519 0.212854239028132 853 719745 SGTC_2488 5268135 45.7 µM -0.797467448805131 0.255593310167068 no 2520 0.212589800199491 879 1270356 YLR208W SEC13 SGTC_2855 9016525 58.44 µM -0.798517527019126 0.255329814370941 no 2521 0.212285113091492 871 43811474 SGTC_2066 5222451 176 µM -0.800517907433403 0.254828252697695 no 2522 0.211705396258608 856 2281147 SGTC_3119 9125183 49.47 µM -0.8025374265651 0.254322415964539 no 2523 0.211121073900272 847 22695334 SGTC_2153 5569715 200 µM -0.803632295226803 0.254048400190152 no 2524 0.210804682994213 866 2054701 SGTC_916 4466-0038 42 nM -0.805255557273288 0.253642427183218 no 2525 0.210336111156549 885 5722064 YGL116W CDC20 SGTC_1068 loratadine 26.9 µM -0.805558214986483 0.253566771095648 no 2526 0.210248813480091 903 3957 A H1 histamine antagonist. SGTC_2065 5221596 34.26 µM -0.807326186726328 0.253125063882942 no 2527 0.209739290391192 868 788581 SGTC_985 1493-0307 8.71 µM -0.807597141548724 0.253057404750652 no 2528 0.209661266397083 883 3278274 SGTC_175 3793-3120 23.7 µM -0.808039218542056 0.252947035758815 no 2529 0.209534002810831 888 5322297 SGTC_331 k048-0133 24.5 µM -0.808096730191493 0.252932679256342 no 2530 0.209517449898345 865 6813582 SGTC_1275 0867-0008 21.1 µM -0.808227201635043 0.252900111556112 no 2531 0.209479900664875 874 3422836 SGTC_3154 9100113 49.47 µM -0.808293338301499 0.252883603659204 no 2532 0.209460868271543 881 25237525 SGTC_2871 9038510 12.99 µM -0.809470785310309 0.252589804551044 no 2533 0.209122200306377 879 4945164 SGTC_1173 0443-0020 122 µM -0.810219625370431 0.252403045956525 no 2534 0.20890697998516 885 5331295 SGTC_365 0121-0052 13.6 µM -0.813822515796447 0.251505513710423 no 2535 0.207873317204032 842 3101739 SGTC_1002 4049-0206 172 µM -0.815308425780719 0.251135843775632 no 2536 0.207447893496869 873 4662749 SGTC_2659 sanguinarine 24.21 µM -0.815807006993475 0.251011869408305 no 2537 0.20730526251346 876 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1925 st057770 10.1 µM -0.815885988717651 0.250992233233906 no 2538 0.207282673239303 886 5989122 SGTC_391 gliotoxin 8.33 µM -0.816074801383119 0.25094529454949 no 2539 0.207228677518488 901 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_348 k064-0012 10.7 µM -0.818051618056643 0.250454138501925 no 2540 0.206663856806104 876 5066323 SGTC_777 1315-0167 517 µM -0.818863208184613 0.250252640001758 no 2541 0.206432231586339 858 4221767 SGTC_2421 5690543 90.72 µM -0.820212896097207 0.24991773507623 no 2542 0.206047375754551 876 3397993 SGTC_320 4092-0846 5.34 µM -0.820569767904077 0.249829222441035 no 2543 0.205945686958621 858 1359356 SGTC_390 dec-rvkr-cmk 16.7 µM -0.821690705067208 0.249551311823112 no 2544 0.205626475301628 874 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_214 4373-3496 70 µM -0.821750627849149 0.249536459972229 no 2545 0.205609419237538 886 3779166 SGTC_685 1278-0033 54.9 µM -0.821998798244964 0.249474955983991 no 2546 0.205538790434657 883 3590572 SGTC_3322 9139058 2.11 µM -0.822005232855613 0.249473361403682 no 2547 0.205536959348821 871 4908926 YPR165W RHO1 SGTC_1333 1482-0047 286 µM -0.822237884173105 0.249415711016007 no 2548 0.205470760678376 899 3811116 SGTC_1679 SEC14.276 6.7 µM -0.823998665527698 0.24897962368841 no 2549 0.204970158105319 877 1005053 YMR079W SEC14 SGTC_3195 9113082 49.47 µM -0.825546798724993 0.248596537737145 no 2550 0.20453061249027 862 17018038 SGTC_2440 5628896 157.78 µM -0.828963439657669 0.247752201440061 no 2551 0.203562547754223 893 5522048 SGTC_1508 1080-0625 72.9 µM -0.831684066207517 0.247080964150412 no 2552 0.202793648397325 863 767111 SGTC_687 k029-0044 34.9 µM -0.832353945613672 0.246915839824842 no 2553 0.202604594649754 862 5829338 SGTC_2059 5238311 157 µM -0.832929746705508 0.246773952884065 no 2554 0.202442175958513 889 703021 SGTC_1486 3970-0793 4.53 µM -0.833696111635139 0.24658517558621 no 2555 0.202226124912027 894 2844330 SGTC_780 0109-0199 192 µM -0.834384692890941 0.246415624601035 no 2556 0.202032120074535 871 610414 SGTC_3205 9113483 49.47 µM -0.835555676581805 0.246127434054239 no 2557 0.201702456296457 888 17018033 SGTC_2371 9071574 200 µM -0.835587129464189 0.246119695685832 no 2558 0.201693605899511 899 45596039 SGTC_722 3534-0461 190 µM -0.83775814788804 0.245585874437674 no 2559 0.201083274240986 876 658262 SGTC_2794 7785382 27.27 µM -0.839128669951667 0.245249203869387 no 2560 0.200698554631025 870 2205081 SGTC_1859 st055998 20 µM -0.841460408506164 0.244676979868644 no 2561 0.200045027941626 897 676301 SGTC_1516 st013856 110 µM -0.843133853916617 0.244266748887238 no 2562 0.199576793504555 890 5281404 A mutagen and neurotoxin. SGTC_2847 9005661 71.43 µM -0.845059759739098 0.243795088642574 no 2563 0.199038737094595 857 2991449 SGTC_1356 1502-0781 85.8 µM -0.846161131745151 0.243525580361651 no 2564 0.198731430816363 885 567702 SGTC_198 3454-2873 16.191 µM -0.847713117280767 0.243146079229425 no 2565 0.198298879671738 883 710957 SGTC_1315 1237-0019 3.69 µM -0.849861486880112 0.242621274704042 no 2566 0.197701049943207 883 825140 SGTC_1171 0368-0077 21.4 µM -0.852243625763356 0.242040082751656 no 2567 0.197039443932802 884 3239779 SGTC_2585 alliin 100 µM -0.853337014500067 0.241773571844603 no 2568 0.196736219609234 881 87310 A garlic compound which reacts with lipids. SGTC_645 0845-0943 5.41 µM -0.853536358581583 0.241724999368797 no 2569 0.196680966933883 884 1885106 SGTC_573 3702-0553 84.7 µM -0.853746908092794 0.241673702313309 no 2570 0.196622618630584 879 1222756 SGTC_478 N-arachidonylglycine 10 µM -0.853801270120067 0.2416604588258 no 2571 0.196607555316585 862 5283389 SGTC_2020 4017018 200 µM -0.853836749276946 0.2416518157298 no 2572 0.196597724682767 915 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.854966887864708 0.241376589906558 no 2573 0.196284739526026 847 88881 An O-methylated flavonoid and antioxidant. SGTC_2284 7945075 39.21 µM -0.855868961011474 0.241157027775173 no 2574 0.196035132657132 891 1245402 SGTC_2424 5537928 59.2 µM -0.860821047808544 0.239953639606906 no 2575 0.194668305394442 881 5382802 SGTC_3026 9090633 49.47 µM -0.861606004422146 0.239763191360907 no 2576 0.194452182859477 885 25236842 SGTC_1579 chlormadinone acetate 49.4 µM -0.862296877708084 0.239595638122619 no 2577 0.1942620852361 904 45114258 A steroidal progestin. SGTC_3183 9108214 49.47 µM -0.86382083328145 0.239226268672631 no 2578 0.193843160727799 879 4974831 SGTC_1828 st055811 49 µM -0.866317273138711 0.238621865785507 no 2579 0.193158098205954 895 5877589 SGTC_1547 harmine 94.2 µM -0.866737421311027 0.238520227644726 no 2580 0.193042948383603 878 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1637 st007924 17.4 µM -0.868245088426902 0.238155702724542 no 2581 0.192630087916642 868 683336 SGTC_2616 abietic acid 100 µM -0.869321974853866 0.237895519295934 no 2582 0.192335523338116 900 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2523 spermine 47.74 µM -0.869877614098483 0.237761333878862 no 2583 0.192183645150024 850 1103 A DNA binding polyamine. SGTC_2194 5927483 104.545 µM -0.870293699386432 0.237660877566509 no 2584 0.192069960635182 863 760979 SGTC_958 1222-0007 33 µM -0.870755610543567 0.237549384703029 no 2585 0.19194380359908 890 7312461 SGTC_2324 6149169 200 µM -0.870869431050702 0.237521915919142 no 2586 0.191912724766836 890 2888231 SGTC_2867 9039098 71.43 µM -0.872508067166666 0.237126650222988 no 2587 0.191465634577339 883 6463460 SGTC_3298 9116858 71.43 µM -0.880576238336374 0.235185756426104 no 2588 0.189273612148008 947 2506942 SGTC_1923 st058458 19.1 µM -0.882801436331618 0.23465200634265 no 2589 0.188671782158966 927 3534982 SGTC_2793 7325131 81.82 µM -0.883263327745082 0.234541298156832 no 2590 0.188547006399923 877 4176441 SGTC_1596 piperlongumine 63 µM -0.88672687479642 0.233712061100104 no 2591 0.187612982808789 892 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3014 9081533 49.47 µM -0.88794793694392 0.233420104247403 no 2592 0.187284378608031 905 21367265 SGTC_3045 9092950 49.47 µM -0.888533312702864 0.233280212256294 no 2593 0.187126972408235 882 44120432 SGTC_747 3448-8087 38.7 µM -0.893415791959342 0.232115220850341 no 2594 0.185817274415444 934 5168703 SGTC_1796 st049173 110.4 µM -0.895518870019901 0.23161441234076 no 2595 0.185254891579612 902 94134 SGTC_1256 0570-0116 285 µM -0.897775009555909 0.231077825344996 no 2596 0.184652755166388 912 410638 SGTC_995 3931-2021 34.6 µM -0.901266938140693 0.23024869511961 no 2597 0.183723204007973 922 730143 SGTC_17 0960-0276 49.807 µM -0.901602093257457 0.230169202853602 no 2598 0.183634139329284 903 6821114 SGTC_2490 carminic acid 95.39 µM -0.902022926698398 0.230069411102511 no 2599 0.183522344457286 892 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.904122594783429 0.229571881097437 no 2600 0.182965199315449 901 16725076 SGTC_2461 5755302 26.15 µM -0.905187108001875 0.229319868224046 no 2601 0.182683135269084 946 2788904 SGTC_1338 1486-1223 76 µM -0.906035293182764 0.229119179920924 no 2602 0.18245858611694 906 3444526 SGTC_3289 9119912 71.43 µM -0.907369079878739 0.228803793243881 no 2603 0.182105827385929 917 17014829 SGTC_2844 9010103 25.97 µM -0.908673669631563 0.22849554636173 no 2604 0.181761203391825 903 2480525 SGTC_3003 9075612 71.4286 µM -0.910656435989249 0.228027507773335 no 2605 0.181238212272682 924 6501993 SGTC_311 1315-0136 58 µM -0.914217174143993 0.227188338928009 no 2606 0.180301370814977 905 6759207 SGTC_2763 lisinopril 49.32 µM -0.914316548064664 0.227164944199739 no 2607 0.18027526888566 897 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3326 9140064 16.379 µM -0.915576405630449 0.226868464775188 no 2608 0.179944555571801 917 1868434 SGTC_1061 3448-9325 110 µM -0.91611182485089 0.226742531905952 no 2609 0.179804123166378 886 723482 SGTC_1287 0971-0001 34.6 µM -0.916126241096885 0.226739141689225 no 2610 0.179800342954009 886 4665869 SGTC_3296 9122258 64.045 µM -0.916225929734924 0.226715699053482 no 2611 0.179774204073881 917 4730474 SGTC_1550 gossypolone 36.6 µM -0.916516678679854 0.226647334764996 no 2612 0.179697981821562 912 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_270 tamoxifen 5.46 µM -0.916825809521689 0.22657466107346 no 2613 0.179616962877478 925 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2044 5102272 200 µM -0.91703618521571 0.226525211291662 no 2614 0.179561839428825 903 592666 SGTC_1760 st045453 10.4495 µM -0.917251599380734 0.226474583508239 no 2615 0.179505406799184 902 3323419 YIL048W NEO1 SGTC_3213 9129884 49.47 µM -0.917347450281691 0.226452058173497 no 2616 0.179480300064439 918 17190742 SGTC_1622 st003707 19.4 µM -0.917476767431999 0.22642167014478 no 2617 0.179446430835726 888 10140899 SGTC_968 1309-0633 340 µM -0.919017034824539 0.22605990230221 no 2618 0.179043331074639 909 3761976 SGTC_79 0052-0007 94.094 µM -0.921427496852 0.225494405153611 no 2619 0.17841363918154 872 2801472 SGTC_745 0469-0705 296 µM -0.921834912380976 0.225398904172104 no 2620 0.178307346860153 918 3486736 SGTC_2285 7945142 200 µM -0.922555339658289 0.225230087160112 no 2621 0.17811948930035 901 2970608 SGTC_1891 st059073 26.2 µM -0.92311213175852 0.225099663695168 no 2622 0.177974386518143 896 688754 SGTC_276 colchicine 750 µM -0.923621980716832 0.224980273773088 no 2623 0.177841582747955 899 2833 A microtubule depolymerizer. SGTC_898 1000-0849 28.3 µM -0.925994848981436 0.224425098196413 no 2624 0.177224328585739 919 6751807 SGTC_2701 st077767 14.721 µM -0.926393629034094 0.224331872742354 no 2625 0.177120726900125 898 5721188 SGTC_1023 4482-3888 16 µM -0.926996486502886 0.224190980504777 no 2626 0.176964179256113 922 3303168 SGTC_1021 4476-0760 85.3 µM -0.928655777413332 0.223803451575175 no 2627 0.176533752826967 925 746768 SGTC_2657 nystatin 74.44 µM -0.930330889340577 0.223412614146581 no 2628 0.176099894612149 905 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_383 2324-0395 7.37 µM -0.933547327772873 0.222663243902118 no 2629 0.175268723147787 862 3146421 SGTC_2600 tangeritin 87.95 µM -0.933778469030493 0.222609447530763 no 2630 0.175209089063712 916 68077 A bioactive flavone. SGTC_1264 0783-0040 158 µM -0.93384680465024 0.222593544353783 no 2631 0.17519146104522 902 2855798 SGTC_1757 st041620 31.8375 µM -0.934514778169127 0.222438126579877 no 2632 0.175019208253131 949 5289815 SGTC_2957 9076800 11.52 µM -0.9354603293197 0.222218230508656 no 2633 0.174775559272659 944 16459615 SGTC_2671 danthron 100 µM -0.936112420805089 0.222066653312978 no 2634 0.174607654286336 904 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.936632434000834 0.221945819730055 no 2635 0.174473831157811 911 2374 Ca(2+)-ATPase inhibitor. SGTC_2690 usnic acid 100 µM -0.936920131546589 0.221878984628178 no 2636 0.17439982144755 917 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_682 0kpi-0099 17 µM -0.937477695382676 0.221749489538337 no 2637 0.17425644587562 917 1714895 YML126C ERG13 SGTC_799 1310-0557 151 µM -0.940969669318368 0.220939455668908 no 2638 0.173360201338084 934 5354492 SGTC_403 arphamenine a 50 µM -0.943160618545615 0.220432086718585 no 2639 0.172799376714572 919 5487158 An arginine aminopeptidase inhibitor. SGTC_1489 4065-0444 182 µM -0.946608713820945 0.219634948266481 no 2640 0.171919101008324 887 2877968 SGTC_226 1,3-diallylurea 8.28947 mM -0.947322987568711 0.219470028064884 no 2641 0.171737110307299 911 74537 YKL182W FAS1 SGTC_843 0310-0051 143 µM -0.950043748845969 0.218842477637788 no 2642 0.171045011748927 913 2065037 SGTC_515 4092-1064 102 µM -0.950944631813433 0.218634914462204 no 2643 0.17081624172927 950 717353 SGTC_372 0155-0182 15.9 µM -0.957733952553225 0.217074306467929 no 2644 0.169098465694138 840 771486 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.957979383416955 0.217018012007512 no 2645 0.169036577337539 897 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1726 st035556 14.5795 µM -0.959256686832451 0.216725173253207 no 2646 0.168714724755585 910 5919439 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.960071210570517 0.216538552266244 no 2647 0.168509688342258 935 688751 SGTC_1889 st059080 5.18 µM -0.961341375055775 0.216247721992444 no 2648 0.168190275367223 920 176925 Isolated from Daphnopsis sellowiana. SGTC_495 decylubiquinone 155 µM -0.961655487749604 0.216175834327892 no 2649 0.168111344397559 933 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3155 9099265 49.47 µM -0.962131731296099 0.216066867882838 no 2650 0.167991718280977 923 25236499 SGTC_2583 asiatic acid 100 µM -0.965681597408284 0.215255647181006 no 2651 0.167101765356336 932 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1127 asiatic acid 681.4 nM -0.969498369264217 0.214385407889658 no 2652 0.166148296730201 939 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1559 coumarin 343 70.1 µM -0.971882808764868 0.213842786073851 no 2653 0.165554426570679 921 108770 A hepatotoxic, DNA x-linker. SGTC_824 1304-0008 100 µM -0.976329381060302 0.21283302817162 no 2654 0.164450632267084 923 768245 SGTC_165 k038-0023 64.381 µM -0.977241479889413 0.212626247086871 no 2655 0.164224808494884 937 46368543 SGTC_111 0083-0039 52.457 µM -0.980465327390122 0.211896312433105 no 2656 0.163428238298115 886 759313 SGTC_1710 st031758 61.5 µM -0.980544817933139 0.211878332941263 no 2657 0.163408628988637 924 5394341 SGTC_955 1216-0110 33 µM -0.98075606916765 0.211830555622233 no 2658 0.163356523414586 926 3619719 SGTC_2888 9058547 12.99 µM -0.981380480512072 0.211689373422035 no 2659 0.163202574112154 910 16476514 SGTC_1284 0929-0043 16 µM -0.98225259237331 0.211492277230506 no 2660 0.162987711823084 928 1239883 SGTC_662 k832-1615 104 µM -0.98277904865354 0.211373350797466 no 2661 0.162858097786213 928 5878478 SGTC_2664 lyso-paf C-16 73.48 µM -0.985564484139063 0.210744773332316 no 2662 0.162173436713042 926 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3065 9113888 49.47 µM -0.986519538061981 0.210529503030557 no 2663 0.161939116211111 940 16648368 SGTC_1893 st059353 36.1 µM -0.986655099358445 0.210498957813642 no 2664 0.161905874411498 966 3112488 SGTC_2157 5649910 96.377 µM -0.988418548722054 0.210101847359435 no 2665 0.161473853492855 929 2858091 SGTC_1808 st050063 61.5 µM -0.988547212300354 0.210072890896794 no 2666 0.161442362129095 920 4011993 SGTC_2092 5303694 80.6725 µM -0.988745343444462 0.210028304952886 no 2667 0.161393875896637 922 1963699 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.989441147570014 0.209871770476499 no 2668 0.161223675434035 936 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3062 9077494 49.47 µM -0.990832606679792 0.209558940839664 no 2669 0.160883662335385 834 16459633 SGTC_1709 st033179 39.1045 µM -0.996996779094038 0.208176406303017 no 2670 0.159383036675933 934 573381 SGTC_1861 st057647 17.4 µM -0.9986581684235 0.207804703642307 no 2671 0.158980155725734 924 688668 SGTC_2507 purpurin 79.67 µM -1.00110211306596 0.207258632864479 no 2672 0.158388721789614 936 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3020 9089140 49.47 µM -1.00192326747985 0.207075346170609 no 2673 0.158190327025388 943 17217859 SGTC_1012 4112-3522 18 µM -1.00364490425095 0.206691377729237 no 2674 0.157774901135595 920 3112398 SGTC_1054 3429-0080 167 µM -1.00442247477782 0.206518098175022 no 2675 0.157587510763566 947 1162877 SGTC_3101 9120531 49.47 µM -1.00879275943859 0.205545793859183 no 2676 0.156537017134428 953 24824904 SGTC_2744 captopril 92.04 µM -1.00922586116703 0.205449585289773 no 2677 0.156433163327057 914 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1413 3910-0535 34.4 µM -1.01296565979473 0.204619945011632 no 2678 0.155538281916372 928 2876951 SGTC_1448 4255-0083 152 µM -1.0151920137367 0.204126996585128 no 2679 0.155007153382572 956 5399660 SGTC_57 miconazole 162.5 nM -1.01606345532523 0.20393423902664 no 2680 0.154799585079098 896 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2505 galangin 7.89 µM -1.01644346176551 0.203850217895658 no 2681 0.154709129026901 934 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3024 9090631 49.47 µM -1.01668033319235 0.203797854999366 no 2682 0.154652762250596 903 25236383 SGTC_3108 9121785 49.47 µM -1.01691907994039 0.203745085657716 no 2683 0.154595962950481 885 17140271 SGTC_899 1083-0020 478 µM -1.01941828277156 0.203193184866027 no 2684 0.154002215039518 942 767123 SGTC_80 0159-0065 512.242 µM -1.02518419696758 0.201923302904943 no 2685 0.152638141687887 911 1548079 SGTC_2716 st080858 38.6235 µM -1.02651125594905 0.201631706091084 no 2686 0.15232533037571 920 5296050 SGTC_856 0433-0016 11.3 µM -1.02673669099582 0.201582195961027 no 2687 0.152272233655929 935 3911780 SGTC_2707 st078556 66.6 µM -1.02681117326811 0.201565839737101 no 2688 0.152254693546 913 17250899 SGTC_1896 st058441 89 µM -1.02851324029665 0.201192284448993 no 2689 0.151854232956461 921 688759 SGTC_1293 1000-1278 195 µM -1.02895338895584 0.201095751937149 no 2690 0.151750789217229 935 678847 SGTC_2533 agelasine 13.65 µM -1.02923531395025 0.201033935316125 no 2691 0.151684555812875 911 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2863 9028737 58.44 µM -1.03106394653365 0.200633254818005 no 2692 0.151255416721233 929 6460917 SGTC_2074 5212007 75.395 µM -1.03215527001762 0.200394358292445 no 2693 0.150999692725248 901 758611 SGTC_1059 3448-6867 171 µM -1.03704241011782 0.199326634977052 no 2694 0.149858046311932 925 3934407 SGTC_1066 ketoconazole 628 nM -1.03748962579231 0.199229100415089 no 2695 0.149753864033423 937 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_908 3448-7491 47.7 µM -1.04058873629923 0.198553996540457 no 2696 0.149033230520054 883 1203031 SGTC_2135 5326629 150.42 µM -1.04066695439191 0.198536975543952 no 2697 0.149015072555269 949 5020077 SGTC_3110 9122132 49.47 µM -1.04121930124833 0.198416804700684 no 2698 0.148886889881904 936 918317 SGTC_1852 st056254 31.4 µM -1.04301192169282 0.198027097319191 no 2699 0.148471385662905 932 442583 SGTC_1319 1306-0155 43.7 µM -1.04490575329971 0.197615889618929 no 2700 0.14803326523852 940 3122360 SGTC_2308 7584454 197.62 µM -1.04718430637669 0.197121831984513 no 2701 0.147507290971205 945 893577 SGTC_3347 9188721 44.724 µM -1.04996329162444 0.19652027862062 no 2702 0.14686749513848 951 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2796 7949634 45.45 µM -1.05003206918238 0.196505404797885 no 2703 0.146851684367719 939 2971588 SGTC_1951 sophoraflavanone G 9.2 µM -1.0536369719491 0.195726764339641 no 2704 0.146024577696362 932 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2208 7283366 200 µM -1.05381810414162 0.19568769019541 no 2705 0.14598310158155 928 898663 SGTC_2738 aclarubicin 5.55 µM -1.0538465702729 0.195681549863827 no 2706 0.145976584053479 936 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2525 harmine 47.85 µM -1.05513072795438 0.195404670280744 no 2707 0.145682770145599 919 5280953 A monoamine oxidase inhibitor SGTC_3012 9080433 71.4286 µM -1.05520387509023 0.195388906060227 no 2708 0.145666046135424 938 17688859 SGTC_953 1188-0045 9.7 µM -1.0564544448198 0.195119510493971 no 2709 0.145380321544839 935 6144426 SGTC_3243 9134147 49.47 µM -1.05761419324501 0.194869881369422 no 2710 0.145115684542799 933 24282180 SGTC_1556 plumbagin 1.48 µM -1.05951061692692 0.194462105866103 no 2711 0.144683648325572 914 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3094 9117742 49.47 µM -1.06132358613074 0.194072761042593 no 2712 0.144271435207067 950 17149698 SGTC_1522 st012842 45.6 µM -1.06226463560463 0.193870853005634 no 2713 0.144057782075672 915 3491067 YOR116C RPO31 SGTC_632 0781-2353 4.65 µM -1.06337858417601 0.193632013933538 no 2714 0.14380515033953 966 6811515 YHR007C ERG11 SGTC_1326 1431-2094 10.8 µM -1.06462087244793 0.193365869584432 no 2715 0.143523765265085 955 616278 SGTC_3083 9117465 49.47 µM -1.07033590800041 0.19214437431102 no 2716 0.142234068508932 959 16420915 SGTC_1568 digitonin 820 nM -1.07193329768253 0.191803804401017 no 2717 0.141874996503343 963 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_191 3914-0123 66.505 µM -1.07347321879844 0.191475837145925 no 2718 0.141529424227889 966 3144412 SGTC_3280 9140961 49.47 µM -1.07392135249557 0.191380459710655 no 2719 0.141428966185018 964 4901226 SGTC_3 0833-0587 95.581 µM -1.07481544614781 0.191190254494797 no 2720 0.141228681802473 940 5382644 SGTC_2441 5730946 39.09 µM -1.07527834178323 0.19109182583629 no 2721 0.141125064930309 913 1774275 SGTC_1793 st048256 72.231 µM -1.07560572118705 0.191022231682207 no 2722 0.141051813817435 931 672022 SGTC_1224 0823-0416 294 µM -1.07619330340834 0.190897362733226 no 2723 0.140920407027809 946 3598164 SGTC_296 1222-0039 74.9 µM -1.07673350038372 0.190782607963556 no 2724 0.140799670757434 947 5984176 SGTC_1229 0139-0193 12.2 µM -1.07896084402329 0.190309897603827 no 2725 0.140302591642542 944 3090752 SGTC_3157 9099274 49.47 µM -1.08105936079306 0.189865187102353 no 2726 0.139835354625184 931 17217662 SGTC_1132 3456-3614 2.5 µM -1.08118031463985 0.189839574466465 no 2727 0.139808456395955 961 3125502 SGTC_1191 1487-1166 10.6 µM -1.0819144065891 0.189684172076974 no 2728 0.13964528136794 993 3955771 SGTC_1644 st010134 20.9 µM -1.08338670925221 0.189372731309179 no 2729 0.139318406229371 950 3818134 SGTC_1501 4491-0275 38.4 µM -1.08461474708478 0.189113201535805 no 2730 0.139046160355789 941 5104718 SGTC_3042 9091578 49.47 µM -1.08500391248667 0.189031002233826 no 2731 0.138959961209153 936 25236497 SGTC_2747 doxorubicin 7.63 µM -1.08653845672285 0.188707091177896 no 2732 0.13862041818971 871 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1317 1273-0028 910 nM -1.08737750183355 0.188530130590631 no 2733 0.13843500493928 933 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_897 1000-0139 31.4 µM -1.08769118079912 0.188463999750573 no 2734 0.138365731188623 959 6151020 SGTC_987 1497-1013 404 µM -1.08877578593427 0.188235449968661 no 2735 0.138126386030189 964 1676435 SGTC_3078 9116413 49.47 µM -1.08895640602347 0.188197406023416 no 2736 0.13808655514384 945 17177322 SGTC_136 0097-0015 404.482 µM -1.09028463149121 0.187917788120423 no 2737 0.137793891452496 954 4861337 SGTC_401 neomycin 50 µM -1.09507264729635 0.186911946170943 no 2738 0.136742405416239 931 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1605 st000082 49.1 µM -1.10148635495643 0.185569818483309 no 2739 0.135342519967739 921 1114022 SGTC_216 k038-0035 28.382 µM -1.10199085116775 0.185464502298361 no 2740 0.135232824524909 955 4444231 YPR107C YTH1 SGTC_22 0964-0034 14.468 µM -1.10482627287015 0.184873283838328 no 2741 0.134617436953929 966 138402 SGTC_2745 rifampicin 24.3 µM -1.10597439198634 0.184634221159192 no 2742 0.134368801728869 918 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.10651512598122 0.184521695521273 no 2743 0.134251810355227 939 17037758 SGTC_2648 atorvastatin 78.68 µM -1.10830956387367 0.184148582389195 no 2744 0.13386407324991 949 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1144 3486-0183 12.5 µM -1.11048581575665 0.183696710209697 no 2745 0.13339486849464 962 6744069 SGTC_983 1491-0821 12.2 µM -1.11066887376873 0.183658731969945 no 2746 0.133355452426411 949 46495113 SGTC_884 0851-0618 334 µM -1.11146362620913 0.183493904914961 no 2747 0.133184419166931 952 9642473 SGTC_3342 9147791 14.508 µM -1.1123751833149 0.183304966814123 no 2748 0.132988435105613 946 1838168 SGTC_159 3970-0959 50 µM -1.11407922180648 0.18295209687959 no 2749 0.132622600845515 929 6615653 SGTC_2269 7935389 174.42 µM -1.11559170773217 0.18263924873589 no 2750 0.132298471607922 939 97605 SGTC_2676 harmalol 100 µM -1.11721503168319 0.182303846362517 no 2751 0.131951197501686 942 5459187 A monoamine oxidase inhibitor SGTC_3162 9099653 49.47 µM -1.11818016945407 0.182104617403302 no 2752 0.131745025996427 928 25237511 SGTC_2046 4110841 106 µM -1.1191507454847 0.181904403167739 no 2753 0.131537917039854 941 44119630 YMR134W ERG29 SGTC_709 3807-1509 243 µM -1.12223061863455 0.181269986857764 no 2754 0.130882198622121 985 1886677 YPL242C IQG1 SGTC_1620 st003704 16.5 µM -1.12295771069812 0.181120417172957 no 2755 0.130727727719248 952 2834414 SGTC_1967 st070177 51.4 µM -1.12536734730749 0.18062528511026 no 2756 0.130216700903712 984 5729214 SGTC_588 3970-1144 52.9 µM -1.125765768796 0.180543499325249 no 2757 0.130132338496386 929 1888707 SGTC_1773 st048542 73.5835 µM -1.126723252285 0.18034704734719 no 2758 0.129929754093247 963 3237138 SGTC_3181 9108277 49.47 µM -1.1267876299665 0.180333843450051 no 2759 0.129916140897918 972 17097298 SGTC_3315 9136395 68.55 µM -1.13205001181525 0.179256577994254 no 2760 0.128806704545761 966 16876844 SGTC_514 4466-0038 2.65 nM -1.13341417900098 0.178977980389493 no 2761 0.128520181236983 917 5722064 SGTC_1979 st071809 45.3 µM -1.13537525697588 0.178577956101611 no 2762 0.128109061125896 969 4976333 SGTC_3349 9149703 23.001 µM -1.13771548580715 0.178101329444683 no 2763 0.127619652470067 963 4910494 SGTC_2667 digitoxin 100 µM -1.14126030091885 0.177380897669438 no 2764 0.12688080863717 919 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2121 5257820 149.641 µM -1.14528763930444 0.17656463610759 no 2765 0.126045012293401 957 791256 SGTC_1795 st049545 62.3 µM -1.14794785478547 0.176026768180055 no 2766 0.125495045535027 913 5291882 SGTC_2492 derrusnin 100 µM -1.15057067622654 0.175497477697778 no 2767 0.124954451266188 972 1715307 Part of coumarin class of compounds. SGTC_2994 9053520 71.4286 µM -1.15719247915118 0.174165678813603 no 2768 0.123596864885942 963 4647384 SGTC_1654 st012436 41.8 µM -1.15720329350909 0.174163509061423 no 2769 0.123594656233268 981 4323132 SGTC_23 0213-0011 39.996 µM -1.16182997782606 0.173236804694113 no 2770 0.122652267252457 979 627608 SGTC_327 1273-0057 3.96 µM -1.16615981783966 0.172372406603081 no 2771 0.121774917643476 945 3108138 SGTC_3345 9148410 3.559 µM -1.16824937309581 0.171956239188787 no 2772 0.1213530950736 932 4903596 SGTC_1787 fluconazole 80 µM -1.16867700676394 0.171871148437694 no 2773 0.121266894634643 927 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3176 9106582 49.47 µM -1.17130561218891 0.171348698017142 no 2774 0.120737978190533 940 17018027 SGTC_1186 1319-0216 26 µM -1.17156090642055 0.171298010966112 no 2775 0.120686695654969 967 4565136 SGTC_1039 k821-0043 94 µM -1.17360641719296 0.170892233921071 no 2776 0.12027635482214 987 15992768 SGTC_2010 4012422 159 µM -1.17561416288291 0.170494547113949 no 2777 0.119874546691304 961 952393 SGTC_181 1447-1644 8.07 µM -1.17628300234865 0.170362197578214 no 2778 0.119740902896975 995 534600 SGTC_602 3130-1533 38.1 µM -1.17643739866709 0.170331655082584 no 2779 0.119710067212706 985 720941 SGTC_710 3448-4187 58 µM -1.17816487836729 0.169990166300947 no 2780 0.119365440674062 960 3946412 SGTC_426 0988-0037 14.6 µM -1.18148899282769 0.169334289885368 no 2781 0.118704261784346 975 5383008 SGTC_1624 st003710 6.25 µM -1.18200430537562 0.169232759892096 no 2782 0.11860199627075 973 24207033 SGTC_2595 hexamethylquercetagetin 100 µM -1.18331678492325 0.168974343812331 no 2783 0.118341811528849 987 386331 SGTC_346 4513-0042 7.16 µM -1.18409397943385 0.168821440359832 no 2784 0.118187931553848 944 2827372 SGTC_2387 9077560 195.08 µM -1.185430059047 0.168558790996037 no 2785 0.117923726394866 972 5303272 SGTC_85 0868-0259 160.055 µM -1.18661565789415 0.168325943563209 no 2786 0.117689628434366 945 83173 SGTC_2093 5331342 194.4 µM -1.19276048238279 0.16712243846265 no 2787 0.116481595395599 971 33839 SGTC_3302 9125395 16.351 µM -1.19284115935249 0.167106674325046 no 2788 0.116465793534556 961 17599668 SGTC_712 r015-0009 80.6 µM -1.19340222833262 0.166997068955791 no 2789 0.11635594135483 978 6813872 YLR060W FRS1 SGTC_1010 4112-3296 15.2 µM -1.19606805394782 0.166476930967988 no 2790 0.115835001469131 966 704384 SGTC_1248 0469-0687 58.6 µM -1.19676133842566 0.166341833505197 no 2791 0.115699795700553 967 4017482 SGTC_1698 5-fluorocytosine 1.055 µM -1.19718001700762 0.166260281647611 no 2792 0.115618198448437 963 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1813 st051246 8.6015 µM -1.1990745977987 0.165891570640633 no 2793 0.115249470212704 953 5291959 SGTC_2848 9016370 25.97 µM -1.20067748735045 0.165580039719272 no 2794 0.114938165098963 946 7894410 SGTC_1446 4239-0190 62 µM -1.20260858234108 0.165205222998757 no 2795 0.114563912481243 995 1340085 SGTC_932 2857-0803 154 µM -1.2039528022503 0.164944640477782 no 2796 0.114303910716382 970 674898 SGTC_358 0075-0058 9.45 µM -1.20415500787358 0.164905465134444 no 2797 0.114264836075682 1010 1069125 SGTC_1454 4239-0054 42.6 µM -1.20465753845582 0.164808130893541 no 2798 0.114167767204924 976 1340767 SGTC_227 fluconazole 33.516 µM -1.205014232208 0.164739066110569 no 2799 0.114098903842231 963 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2555 cholic acid 100 µM -1.20723126685397 0.164310213573051 no 2800 0.113671546148259 966 6708657 Influences liver metabolism. SGTC_15 0266-0086 27.098 µM -1.20921947260018 0.163926240804806 no 2801 0.113289269274519 994 1712902 YIL048W NEO1 SGTC_1587 estradiol valerate 56.1 µM -1.20926862432246 0.163916755746018 no 2802 0.113279830390358 996 13791 A steroid. SGTC_2722 naftopidil 47.16 µM -1.21123037880738 0.163538476739006 no 2803 0.112903561466608 972 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1817 st052116 64.4 µM -1.21647394582093 0.162530161062901 no 2804 0.111902215093342 991 4361398 SGTC_2949 9072542 2.23 µM -1.22526615816095 0.160848553898513 no 2805 0.110237477393937 993 16457352 SGTC_1694 st024011 44.9 µM -1.23004481342093 0.159939365226957 no 2806 0.109340161997332 990 2787533 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.23044661825849 0.159863071181502 no 2807 0.109264952636556 977 5355888 SGTC_374 0880-0231 82.3 µM -1.23060905075042 0.159832235523791 no 2808 0.109234559264117 957 6833587 SGTC_1427 4048-4900 550 nM -1.23175428755998 0.159614937911752 no 2809 0.109020441950577 976 24132586 SGTC_3261 9137475 49.47 µM -1.23297741666085 0.159383074601124 no 2810 0.108792094952514 926 17027690 SGTC_1973 st070275 50.2 µM -1.23376371553739 0.15923413582321 no 2811 0.108645481877511 986 17118334 SGTC_1152 3909-8331 15.9 µM -1.23391210113601 0.159206039219441 no 2812 0.108617829885837 970 16001939 SGTC_3308 9128332 17.569 µM -1.23408868705451 0.159172607156516 no 2813 0.108584929297854 973 17332805 YDL196W YDL196W SGTC_265 mycophenolic acid 32.932 µM -1.2354477847631 0.158915450398917 no 2814 0.10833194902369 1007 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_432 NS 1619 61.3 µM -1.24091949944787 0.157882895849465 no 2815 0.10731774427755 966 4552 A K+/calcium channel activator. SGTC_397 arbidol 50 µM -1.24243591512692 0.157597517995362 no 2816 0.107037885677006 977 131410 A RNA synthesis inhibitor. SGTC_2317 5986382 200 µM -1.24265054186062 0.157557154278955 no 2817 0.106998318297557 1009 877883 SGTC_3214 9129694 49.47 µM -1.24644391464842 0.156844875801348 no 2818 0.106300733755095 1005 17158655 SGTC_1254 0550-0035 264 µM -1.24854500121296 0.156451269729017 no 2819 0.105915769587255 991 15121435 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.25459480856267 0.155321567769781 no 2820 0.104812944503197 990 676296 Flavone; oxidizing agent. SGTC_885 0865-0106 16.8 µM -1.25644349644004 0.154977432309982 no 2821 0.104477609920182 982 2793380 SGTC_1355 1499-0035 1.68 µM -1.25802637955917 0.154683177175221 no 2822 0.10419110809554 998 1548538 SGTC_1498 4478-3555 97.6 µM -1.25883909181172 0.154532238954312 no 2823 0.104044228654438 988 3437919 SGTC_1345 1488-0192 31.4 µM -1.25895321972487 0.154511050733482 no 2824 0.104023614631566 986 658348 SGTC_2766 oltipraz 83.91 µM -1.25897055001728 0.154507833475889 no 2825 0.104020484656841 925 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2348 9022543 33.42 µM -1.26655999324925 0.153103157606947 no 2826 0.102656332559683 970 3162678 YDL140C RPO21 SGTC_2944 9067346 25.62 µM -1.26753652743365 0.1529230344222 no 2827 0.102481755612834 977 6473075 SGTC_110 0850-0284 111.64 µM -1.26760569468956 0.152910281749402 no 2828 0.102469398636656 942 3906265 SGTC_2375 9072683 200 µM -1.27010089033236 0.152450703049136 no 2829 0.10202434727047 998 16798029 SGTC_570 0987-0065 62.6 µM -1.27034607139345 0.152405593782199 no 2830 0.10198069197528 938 3104428 SGTC_2374 9071832 200 µM -1.27038061976837 0.152399238163823 no 2831 0.101974541616209 980 17381698 SGTC_1790 st045711 43.5 µM -1.27748297819786 0.151096402815255 no 2832 0.100715893068895 938 585119 SGTC_2138 5575593 77.673 µM -1.27780052494794 0.151038326581976 no 2833 0.100659884634218 987 762213 SGTC_2075 5212009 200 µM -1.28410054368418 0.149889184901678 no 2834 0.0995533889298816 987 780898 SGTC_3211 9128781 49.47 µM -1.28565459031168 0.149606621209779 no 2835 0.0992818178562313 969 17194361 SGTC_1196 1588-0294 184 µM -1.28582675853948 0.149575338699296 no 2836 0.0992517646607527 991 6144269 SGTC_38 0929-0051 58.268 µM -1.28735091153084 0.149298594515306 no 2837 0.0989860029098178 990 1379719 SGTC_2971 9092186 9.93 µM -1.28759233192637 0.149254790608292 no 2838 0.0989439550001891 977 25236400 SGTC_1115 galangin 695.678 nM -1.28886842385825 0.1490233959411 no 2839 0.0987219166164783 1004 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1134 3477-0009 42.5 µM -1.28954108767703 0.148901517835035 no 2840 0.098605020843722 977 3973534 SGTC_2518 prenyletin 46.28 µM -1.29049082925279 0.148729550207176 no 2841 0.0984401469621886 978 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1814 st052110 31.539 µM -1.29104480977498 0.148629303489679 no 2842 0.098344069936471 988 674163 SGTC_1745 st081495 74 µM -1.29280961492201 0.148310250662471 no 2843 0.0980384570703426 963 13842402 YBL026W LSM2 SGTC_39 0986-0283 58.349 µM -1.29291340982629 0.148291500227726 no 2844 0.0980205045071709 975 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3063 1327-0034 4 µM -1.29338912091345 0.148205583835724 no 2845 0.0979382554369091 972 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2111 5486399 200 µM -1.2938148152039 0.148128729031223 no 2846 0.0978646970179279 961 689674 SGTC_2752 diclazuril 33.15 µM -1.29511524379579 0.147894114983908 no 2847 0.0976402385182805 959 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2561 acetosyringone 100 µM -1.29964739403712 0.14707840193059 no 2848 0.0968609240230549 995 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1034 k072-0165 12.7 µM -1.30536522982535 0.146053596264794 no 2849 0.0958842560769117 1011 5835461 SGTC_1400 3771-8998 51.5 µM -1.30834715016047 0.145521055494679 no 2850 0.0953777947545992 999 670767 SGTC_1360 1598-0022 39.8 µM -1.30856701122216 0.145481842290862 no 2851 0.0953405307695732 997 761525 SGTC_935 2996-0153 430 µM -1.30978540526117 0.145264665083543 no 2852 0.0951342209024493 1000 23738523 SGTC_2947 9072639 7.68 µM -1.31040063462964 0.145155084145168 no 2853 0.0950301695269069 1015 16488146 SGTC_2791 5663188 71.43 µM -1.31047821744459 0.145141269513706 no 2854 0.0950170541983081 986 54690634 SGTC_167 3672-0051 66.205 µM -1.31250023025864 0.144781535804163 no 2855 0.0946757042016109 985 3237971 SGTC_1938 st074717 56.4 µM -1.31579874423583 0.14419599107381 no 2856 0.0941208004406449 948 17250979 SGTC_2539 epi(13)torulosol 80 µM -1.31703872775147 0.143976285480017 no 2857 0.0939128217274229 977 6708597 SGTC_2318 6029776 164 µM -1.31793356370956 0.143817874939112 no 2858 0.0937629444162843 998 818325 SGTC_3070 9117005 49.47 µM -1.32480438921416 0.142605468484796 no 2859 0.092618019330006 1042 8779016 SGTC_376 3970-0862 59.1 µM -1.3252039780091 0.142535171465885 no 2860 0.0925517531650659 994 3135186 SGTC_1664 st014217 9.02 µM -1.32544414996053 0.142492930877807 no 2861 0.0925119409147254 972 3982782 SGTC_1984 st072354 53.1 µM -1.32640212557526 0.142324529778079 no 2862 0.0923532675569635 981 5762938 SGTC_1162 k048-0130 20.1 µM -1.32850158011845 0.141955940866502 no 2863 0.0920062309588031 989 6797406 SGTC_984 1492-0255 2.91 µM -1.32955278390433 0.14177163020586 no 2864 0.0918328318151073 1000 1585198 SGTC_861 0443-0273 110 µM -1.32959189854869 0.141764775248795 no 2865 0.0918263844141678 988 6149169 SGTC_846 0335-0850 148 µM -1.33267207662202 0.141225669735371 no 2866 0.0913197203046933 981 6819598 SGTC_2119 5528445 120.635 µM -1.33378606594305 0.141031037397418 no 2867 0.0911369894258479 1013 791935 SGTC_344 k064-0035 6.43 µM -1.33815572299723 0.140269342999961 no 2868 0.0904228395978584 970 5088750 SGTC_490 phenamil 164 µM -1.34073541244689 0.139820979847351 no 2869 0.0900031863479334 947 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2743 auranofin 4.32 µM -1.34175910770171 0.139643326694325 no 2870 0.0898370575208828 981 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2271 7849410 118.62 µM -1.34279988942639 0.139462865749424 no 2871 0.0896683896120898 1008 972430 SGTC_122 0236-0016 402.397 µM -1.34510647241596 0.139063493302787 no 2872 0.0892954266742505 988 6808838 SGTC_1203 3992-3522 103 µM -1.34836942777486 0.138499860880337 no 2873 0.0887697959662312 1015 5322312 SGTC_1699 st031318 29.054 µM -1.34971755016778 0.138267445614565 no 2874 0.0885533003184525 997 5340658 SGTC_1098 clofazimine 15.1 µM -1.35008582540134 0.138204001510312 no 2875 0.0884942272713853 1007 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3225 9130819 49.47 µM -1.36219166105616 0.136129530860806 no 2876 0.0865687034089962 999 4547121 SGTC_3000 9075062 71.4286 µM -1.36357205737441 0.135894345265085 no 2877 0.0863511457361602 962 17057871 SGTC_1332 1480-0653 17.5 µM -1.36513977840978 0.135627581738018 no 2878 0.0861045608515597 1003 5749438 SGTC_700 3453-2283 142 µM -1.36580957437388 0.135513718656847 no 2879 0.0859993702379768 998 565664 SGTC_1736 st036774 51 µM -1.36812483014227 0.135120637505316 no 2880 0.0856365028524835 989 1272247 SGTC_2220 6782180 200 µM -1.36828645362074 0.135093226503134 no 2881 0.0856112146608835 989 833803 SGTC_2506 ethyl hematommate 54.16 µM -1.37478323406196 0.133994542697527 no 2882 0.0845993287381978 1002 3940691 An allergen. SGTC_1455 4262-0120 131 µM -1.37533761244707 0.133901075765489 no 2883 0.0845134004273686 991 1529587 SGTC_3064 1327-0027 10 µM -1.37593720915261 0.133800035576857 no 2884 0.084420537026182 976 16000455 YPR107C YTH1 SGTC_1060 3448-7350 82 µM -1.37653949307803 0.133698595329169 no 2885 0.0843273345349025 1004 570178 SGTC_1792 st045773 43.6 µM -1.37691492528182 0.133635389558916 no 2886 0.0842692760726048 965 2919270 SGTC_444 curcumin 90.4 µM -1.3776655296196 0.133509083411271 no 2887 0.084153289321693 983 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1035 k081-0041 55.2 µM -1.37810391878648 0.133435352515059 no 2888 0.084085602917045 996 731709 SGTC_3260 9137109 49.47 µM -1.37945178056596 0.133208836565266 no 2889 0.0838777517866172 985 17478346 SGTC_2437 5741531 144.16 µM -1.38011789284086 0.133096990305751 no 2890 0.083775174490487 979 2262990 SGTC_1426 4048-4480 71.7 µM -1.38181912765292 0.13281163103613 no 2891 0.083513622209859 1003 14224343 SGTC_451 chloral hydrate 100 µM -1.39155256793612 0.131187079964879 no 2892 0.0820289653151748 1007 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1906 st060206 94.7 µM -1.39425990838034 0.130737663797005 no 2893 0.0816195664481226 988 5133468 SGTC_164 4100-3994 89.624 µM -1.39498627594583 0.130617268696996 no 2894 0.0815099890777793 1025 4615967 SGTC_2824 7998404 51.95 µM -1.40054512026662 0.129698430851329 no 2895 0.0806750708986031 1004 837851 SGTC_524 r073-0010 27.8 µM -1.40172103456721 0.129504635542728 no 2896 0.0804992834082839 1014 2772106 SGTC_999 SEC7.066 22.7 µM -1.40381455483497 0.129160111882798 no 2897 0.080187039335268 1010 740511 YDR170C SEC7 SGTC_2311 7694451 200 µM -1.40680768450499 0.128668646962798 no 2898 0.0797422116466804 1013 2163142 SGTC_1740 st038286 13.222 µM -1.40849201108605 0.128392655730483 no 2899 0.0794927154569241 991 716786 SGTC_1313 1220-0047 237 µM -1.40943451209142 0.128238398383002 no 2900 0.0793533625306678 1004 3528706 SGTC_2835 9006588 71.43 µM -1.41075343673543 0.128022748634362 no 2901 0.0791586642561589 974 2345538 SGTC_551 k048-0028 34.9 µM -1.41852893039331 0.126756543467952 no 2902 0.0780181992278119 1001 6836383 SGTC_68 0986-0284 82.829 µM -1.42625933897294 0.125506350651863 no 2903 0.0768967484382432 973 423278 YIL048W NEO1 SGTC_1652 st011932 78 µM -1.42778524588123 0.125260595284777 no 2904 0.0766768403975666 998 1551076 SGTC_235 0330-0087 5 mM -1.4297037929325 0.124952080203221 no 2905 0.0764010256019651 1025 46494818 YHR062C RPP1 SGTC_586 0957-0265 8.15 µM -1.43325233000168 0.124382851698514 no 2906 0.0758928698487716 976 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2067 5224629 34.075 µM -1.43700715136643 0.123782509965308 no 2907 0.0753579807714018 1006 2835000 SGTC_236 1509-0011 5.31 µM -1.43838198573261 0.123563201970838 no 2908 0.0751628505268287 1018 3107280 SGTC_1812 st052057 4.327 µM -1.44050944309313 0.123224375209393 no 2909 0.0748616601624075 1018 3645418 SGTC_212 3807-4682 38.772 µM -1.4405096818756 0.12322433721659 no 2910 0.0748616264090287 1014 3125501 YBL034C STU1 SGTC_1888 azatryptophan 97.5 µM -1.4432656559165 0.122786379430672 no 2911 0.0744728252722508 1007 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1561 5-methoxyflavone 52.9 µM -1.44414519843341 0.122646839497357 no 2912 0.074349068178052 990 94525 SGTC_1103 duloxetine 36.1 µM -1.45047678171387 0.121645612636748 no 2913 0.0734628046416501 1031 60835 A selective serotonin reuptake inhibitor. SGTC_3271 9137798 49.47 µM -1.45296448155882 0.121253803432829 no 2914 0.0731168079678566 963 6498326 SGTC_64 000l-0018 272.079 µM -1.45316658115168 0.121222012056569 no 2915 0.0730887542165528 994 6811119 SGTC_2626 ethyl orsellinate 100 µM -1.45869710443774 0.120354304769646 no 2916 0.0723242467092411 1011 75653 A natural product. SGTC_3251 9135047 49.47 µM -1.46115736354046 0.119969713639798 no 2917 0.071986130403016 1027 17682963 SGTC_87 0100-0052 35.5 µM -1.46318774102814 0.119652975296524 no 2918 0.0717080071462204 1044 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1161 k007-0610 110 µM -1.46429720385437 0.119480148798451 no 2919 0.0715563804203916 995 5843850 SGTC_1643 st009866 20.2 µM -1.46590514585825 0.119229984444018 no 2920 0.0713370649393589 989 3156273 YOR207C RET1 SGTC_487 nimodipine 119 µM -1.46596053989632 0.119221372806655 no 2921 0.0713295186656802 1049 4497 L-type voltage-gated calcium channels inhibitor SGTC_3069 9117009 49.47 µM -1.46737905217746 0.119000998386188 no 2922 0.0711364848604788 1014 41904981 SGTC_1910 st062352 60.4 µM -1.46838817779059 0.118844399845721 no 2923 0.0709994055225031 1009 2245730 SGTC_326 k292-0812 17.5 µM -1.47140136795451 0.118377672100761 no 2924 0.070591301852282 1000 3579357 SGTC_3002 9075603 71.4286 µM -1.47293063137757 0.118141293330007 no 2925 0.0703848707542775 999 20105405 SGTC_2805 7950783 58.44 µM -1.47427047823473 0.117934467253364 no 2926 0.0702043902328229 1007 1178958 YDL195W SEC31 SGTC_2035 5154463 94.595 µM -1.47680229722909 0.117544341496475 no 2927 0.069864320307581 1018 2769623 SGTC_2058 5236698 133 µM -1.48321329228515 0.116560565261489 no 2928 0.0690088753583897 1022 766665 SGTC_1581 himbacine 57.9 µM -1.48700565203976 0.115981378417419 no 2929 0.0685066590862358 1046 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3234 9132280 49.47 µM -1.48768876118538 0.115877268346001 no 2930 0.0684164964342149 1009 17612295 SGTC_1174 0739-0097 51.1 µM -1.48961249086493 0.115584436630121 no 2931 0.0681630778934238 1027 728447 SGTC_2257 7960413 200 µM -1.49265360824347 0.115122588379921 no 2932 0.0677639414435256 999 2974689 YIL048W NEO1 SGTC_728 3030-5151 22.5 µM -1.49426399869066 0.114878553764489 no 2933 0.0675533154657657 1040 3125388 SGTC_2900 5328528 85.29 µM -1.49510319679172 0.114751529685231 no 2934 0.0674437558575269 1013 795359 SGTC_3282 9108498 15.4605 µM -1.49635186468811 0.114562711785825 no 2935 0.0672809930938229 1027 16459645 SGTC_1616 st002734 56.1 µM -1.49875779284928 0.11419952196873 no 2936 0.0669682388959182 1025 4026101 SGTC_3090 9117696 49.47 µM -1.5004813532353 0.113939844441102 no 2937 0.0667448800591573 1003 7923821 SGTC_2551 apiole 73.87 µM -1.50211807858332 0.113693639503567 no 2938 0.0665333083536994 1022 10659 A possible DNA adduct former. SGTC_2130 NSC 7 2.4545 µM -1.50353298222712 0.113481107983968 no 2939 0.0663508291898433 1031 21448 SGTC_1266 0828-0227 32.9 µM -1.50375251777597 0.113448157134634 no 2940 0.0663225506026299 1034 3913820 SGTC_2823 7987624 58.44 µM -1.5066490924874 0.113014039024114 no 2941 0.0659503133744217 1029 2239440 SGTC_1783 st039459 87.517 µM -1.50679397689561 0.112992355951438 no 2942 0.0659317369584795 1034 729761 SGTC_354 2783-3500 4.88 µM -1.50727548730651 0.11292031552472 no 2943 0.0658700290258738 1008 6740761 SGTC_2252 omeprazole 400 µM -1.51464621640609 0.111821645458062 no 2944 0.0649310107600386 1033 4594 A proton pump inhibitor. SGTC_1988 st071872 53.4 µM -1.51559348066927 0.111681003956312 no 2945 0.0648110882787508 1025 16414116 SGTC_2275 7947463 200 µM -1.51700376895421 0.111471851218098 no 2946 0.0646328662305726 989 1225414 SGTC_1493 4348-0038 111 µM -1.51727383851041 0.111431830566005 no 2947 0.0645987802580316 1021 800424 SGTC_2851 9015922 71.43 µM -1.51936770676794 0.111121896535015 no 2948 0.0643349829076688 1019 2996893 SGTC_2479 5617353 43.85 µM -1.52100725693868 0.11087964187619 no 2949 0.0641290081098333 1018 2731746 SGTC_617 3770-0098 35 µM -1.52230845498312 0.110687650505699 no 2950 0.0639659052675675 1017 5962639 SGTC_1560 lithocholic acid 53.1 µM -1.52272790968208 0.110625810901719 no 2951 0.0639133961826546 1001 9903 A bile acid which acts as a detergent. SGTC_2485 5633444 17.78 µM -1.52362208356468 0.110494066795795 no 2952 0.0638015716766849 1019 5724239 SGTC_765 1319-0117 244 µM -1.52496422948193 0.110296531405545 no 2953 0.0636340099509188 1001 3487746 YGL099W LSG1 SGTC_2144 5628481 200 µM -1.53055412959516 0.109476540792976 no 2954 0.0629398129067719 1015 2818399 SGTC_2398 5228213 48.84 µM -1.5308438422562 0.10943416207339 no 2955 0.0629039955935327 1032 80771 YMR134W ERG29 SGTC_281 1672-3440 14.9 µM -1.53131718275934 0.109364947911014 no 2956 0.0628455104526056 1027 6833000 SGTC_1570 verbenone 133 µM -1.5336845986178 0.109019244716537 no 2957 0.0625536322572875 1032 29025 A natural terpanoid with antifungal properties. SGTC_1649 st011737 51.3 µM -1.53884928686398 0.108267795673995 no 2958 0.0619205471020224 986 1761035 SGTC_2474 5321570 43.32 µM -1.54082153985664 0.107981823703189 no 2959 0.0616801127811281 1040 2841384 SGTC_217 ketoconazole 989 nM -1.54421154878545 0.107491552170641 no 2960 0.0612685459906347 965 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1081 sertraline 6 µM -1.54954376779689 0.106723643020036 no 2961 0.0606255293347031 1017 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1759 st043059 70 µM -1.55540122217355 0.105884665106525 no 2962 0.0599252716135455 1016 669426 SGTC_2636 apigenin dimethyl ether 100 µM -1.55933953369566 0.105323257234373 no 2963 0.0594580197177413 1027 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2836 9010338 19.48 µM -1.5611062430462 0.105072113013504 no 2964 0.0592493426568234 1025 2994051 SGTC_582 0987-0078 156 µM -1.56414207803763 0.104641570747836 no 2965 0.0588921030681917 1033 1625765 SGTC_1237 0330-0133 46.1 µM -1.56983571497741 0.103837547290446 no 2966 0.0582266681523047 1026 X1237 YHR072W ERG7 SGTC_2464 5717415 7.67 µM -1.57022365095784 0.103782928657082 no 2967 0.0581815445609163 1027 5285744 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.57382648848634 0.103276670004429 no 2968 0.0577637842417482 1018 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1950 st077106 7.18 µM -1.57454289998779 0.103176216341803 no 2969 0.0576809958796473 1011 13831864 SGTC_417 st075190 100 µM -1.57610718846476 0.102957121861472 no 2970 0.0575005513396971 1036 222757 SGTC_1982 st072467 71.9 µM -1.57705384473224 0.102824697308179 no 2971 0.0573915680552273 1028 3163533 SGTC_659 k018-0002 107 µM -1.58040902633541 0.102356348989633 no 2972 0.0570066128909485 1034 6797879 YHR007C ERG11 SGTC_576 1073-0113 22.7 µM -1.58638183340718 0.10152644999272 no 2973 0.0563263594367133 1037 5439563 SGTC_2363 9053361 176 µM -1.58845228620296 0.101239915285367 no 2974 0.056092051110448 1039 6469797 YMR079W SEC14 SGTC_724 3910-0327 137 µM -1.59026473387136 0.100989570564715 no 2975 0.0558875721775286 1037 2885483 SGTC_1273 0849-0096 14.1 µM -1.59039353934916 0.100971796470668 no 2976 0.0558730628542329 1038 5286025 SGTC_2638 epoxomicin 18 µM -1.59075669746604 0.100921695923402 no 2977 0.0558321708235727 1023 9915668 A protesome inhibitor. SGTC_268 camptothecin 39.6153 µM -1.59254672026565 0.100675012873649 no 2978 0.055630957083542 1052 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2361 9034121 116 µM -1.59462018796362 0.100389818386728 no 2979 0.0553985976788706 1052 6496917 SGTC_2959 9079155 11 µM -1.59501453023127 0.100335645489469 no 2980 0.0553544932809238 1034 16189457 SGTC_312 4092-0653 6.84 µM -1.59629893599306 0.100159347743443 no 2981 0.0552110337736227 1002 1148278 SGTC_706 4262-0057 46.9 µM -1.59650068477839 0.100131676235073 no 2982 0.0551885264988859 1047 883298 SGTC_2930 9013230 14.89 µM -1.5969500186256 0.100070066454291 no 2983 0.0551384244600851 1003 2995857 SGTC_1399 3562-5772 25 µM -1.59846133624981 0.0998630473690866 no 2984 0.0549701717548881 1029 23847490 SGTC_2385 9074692 200 µM -1.60183517637459 0.099402030402235 no 2985 0.0545960310797892 1037 17046906 SGTC_863 0466-0191 129 µM -1.6032854875441 0.099204332091429 no 2986 0.0544358195172786 1039 765160 YPR165W RHO1 SGTC_806 3966-4455 5.86 µM -1.60492916612546 0.0989806227781671 no 2987 0.0542546970291704 1031 714982 SGTC_1830 st055982 50.3 µM -1.60688738095643 0.098714586189485 no 2988 0.0540395375397839 1037 455313 An antimicrobial agent. SGTC_1234 0326-0494 15.5 µM -1.60862450818871 0.0984790241925214 no 2989 0.0538492359574402 1032 1547813 SGTC_157 1348-1695 65.819 µM -1.60929213501616 0.0983886006667709 no 2990 0.0537762390240529 1003 5380510 SGTC_1077 5-fluorocytosine 377 nM -1.61005910940225 0.0982847965476964 no 2991 0.0536924763821587 1036 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3161 9100388 49.47 µM -1.61561606917748 0.0975350996300543 no 2992 0.0530886737255915 1058 25236368 SGTC_2226 7298446 200 µM -1.6158284344278 0.0975065325786949 no 2993 0.0530657060011913 1044 3283010 SGTC_666 0272-0154 136 µM -1.61720869664763 0.0973210113421681 no 2994 0.0529166198651794 1053 6870312 SGTC_2297 7971671 152.32 µM -1.62153838446492 0.0967407378648469 no 2995 0.0524511124049507 1027 909016 SGTC_200 k038-0079 37.545 µM -1.62254006851219 0.0966068528200827 no 2996 0.0523438805006947 1050 3436683 SGTC_1226 3909-7979 35.4 µM -1.62738412139527 0.0959613172572907 no 2997 0.0518277708792686 1028 6615510 SGTC_398 bronopol 33.3 µM -1.63199584359738 0.0953496958310737 no 2998 0.0513401808930487 1035 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3004 9076122 71.4286 µM -1.63455268579845 0.0950118382650535 no 2999 0.0510714265417924 1037 44782551 SGTC_2879 9041815 71.43 µM -1.6359680086746 0.094825199060623 no 3000 0.0509231415014183 1047 4942971 SGTC_84 0443-0269 128.823 µM -1.64151037799326 0.0940969247214974 no 3001 0.0503457572941973 1028 6150058 SGTC_2784 7567673 72.73 µM -1.64258404238115 0.0939563222773908 no 3002 0.0502345123175541 1017 3471247 SGTC_1464 k208-0027 110 µM -1.65361244631776 0.092521056168188 no 3003 0.0491031410893373 1026 X1464 SGTC_1311 1190-0148 100 µM -1.65445880792297 0.0924115822723242 no 3004 0.0490171631032007 1036 1961333 SGTC_1026 k007-1105 30.6 µM -1.6573842034678 0.0920339308540828 no 3005 0.0487209115157262 1027 7066794 SGTC_71 0417-1750 47.813 µM -1.66102940808504 0.0915649569405996 no 3006 0.0483537702829666 1002 6811472 SGTC_2803 7707263 71.43 µM -1.66248140059955 0.0913786448113065 no 3007 0.0482081447987116 1023 2199229 SGTC_1912 st060209 90.8 µM -1.66357116222571 0.0912389969809154 no 3008 0.0480990794090465 1038 688787 SGTC_2757 clomiphene 4.22 µM -1.66416376663541 0.0911631239643254 no 3009 0.0480398533815185 1045 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_746 1095-0025 46.6 µM -1.66756388932001 0.0907286996937812 no 3010 0.0477011658423945 1036 6749286 SGTC_272 doxorubicin 8.13 µM -1.66762130180952 0.0907213774717567 no 3011 0.0476954634215086 1049 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2605 digitonin 300 nM -1.67324425527096 0.0900063653991227 no 3012 0.0471396107257997 1038 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1955 wogonin 32.4 µM -1.6786889923099 0.0893180138720909 no 3013 0.0466063361840541 1026 5281703 A flavanone. SGTC_1209 2323-2347 50.3 µM -1.68054665756544 0.0890840566564922 no 3014 0.0464255021902697 1010 5412760 SGTC_3340 9146634 11.102 µM -1.6833507978777 0.0887317632325672 no 3015 0.0461536010374175 1033 4907387 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.68362319429989 0.0886975965350078 no 3016 0.0461272566387194 1028 6708630 An antioxidant. SGTC_2948 9070189 9.45 µM -1.68738831029769 0.0882263410726912 no 3017 0.0457643550533105 1005 6473636 YDL196W YDL196W SGTC_2229 7354935 190 µM -1.69279293315329 0.0875531447680031 no 3018 0.0452474441518499 1047 318112 SGTC_3321 9137793 26.8275 µM -1.70471735463665 0.0860814171639791 no 3019 0.0441235757747095 1043 4904192 SGTC_1071 trifluoperazine 6.31 µM -1.7049286680265 0.0860555045259022 no 3020 0.0441038644562498 1067 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2756 carbadox 75.1 µM -1.71519141785538 0.0848040319909784 no 3021 0.0431550689104828 1013 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2779 methotrexate 400 µM -1.71637167410686 0.0846609872405908 no 3022 0.0430470187812478 1012 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1867 st057372 64 µM -1.71880557352694 0.0843665748739322 no 3023 0.0428248901669937 1053 688837 SGTC_673 1082-0474 110 µM -1.72395958978795 0.0837456653515859 no 3024 0.0423575692595329 1032 3098046 SGTC_2420 aureobasidin a 50 nM -1.72487280377607 0.0836360084561741 no 3025 0.0422751988588189 1043 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_608 k048-0125 159 µM -1.72697568167803 0.0833839093935591 no 3026 0.0420860154993626 1040 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1404 3909-7820 48.3 µM -1.72726501796598 0.0833492676739406 no 3027 0.0420600393506419 999 23741373 SGTC_2827 7993847 71.43 µM -1.73056205368651 0.0829552831561457 no 3028 0.041764952288758 1031 2985692 SGTC_1213 1315-0166 115 µM -1.73082428616978 0.0829240075125781 no 3029 0.0417415544536964 1036 768401 SGTC_1575 cyproterone acetate 48 µM -1.73709225989615 0.0821790834092956 no 3030 0.0411854436748055 1043 9880 An androgen receptor antagonist and liver toxin. SGTC_1407 3909-7909 12.3 µM -1.74242413785198 0.0815493876524955 no 3031 0.0407171276361307 1013 4411780 SGTC_829 1635-0120 117 µM -1.74554769403121 0.0811821890111617 no 3032 0.0404447889961192 1025 285054 SGTC_733 4069-0007 56.1 µM -1.74826210691017 0.0808641027349314 no 3033 0.0402093257840682 1047 5717425 YNL287W SEC21 SGTC_976 1348-1067 47.6 µM -1.75306955161005 0.080303056504204 no 3034 0.0397950346260715 1053 5310671 YGL099W LSG1 SGTC_1371 2421-0008 32.7 µM -1.75527358604237 0.0800468232885376 no 3035 0.039606261154408 1027 2827552 SGTC_611 3453-1652 23.7 µM -1.75725650467297 0.079816824864585 no 3036 0.0394370489714775 1058 1560575 SGTC_1492 4158-0558 28.5 µM -1.75921712382193 0.0795899047279749 no 3037 0.0392703184193708 1032 3967268 SGTC_1206 3978-0017 132 µM -1.76049006233396 0.0794428376290502 no 3038 0.0391623754992926 1028 3873677 SGTC_917 harmaline 728.087 nM -1.76090753340849 0.0793946505290782 no 3039 0.0391270273296466 1026 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2810 7959871 45.46 µM -1.76118663637985 0.0793624470749196 no 3040 0.0391034095726852 1036 2974535 SGTC_1946 st076057 65.1 µM -1.76216580607772 0.0792495467205926 no 3041 0.0390206437702438 1049 953009 SGTC_2027 5150920 200 µM -1.76620620720885 0.0787849656457878 no 3042 0.03868063003094 1015 786715 SGTC_251 melphalan 456.522 µM -1.76819880788655 0.0785566098108091 no 3043 0.0385138367170732 1066 460612 A DNA alkylator. SGTC_1105 epirubicin 18.1 µM -1.77137532890341 0.0781936123475803 no 3044 0.0382491541927069 1045 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3269 9137823 49.47 µM -1.78630540817669 0.0765044992211018 no 3045 0.0370249108660673 1034 17682936 SGTC_848 0368-0089 85.6 µM -1.79232676241315 0.0758311826152876 no 3046 0.0365403193818155 1043 762535 SGTC_694 1315-0438 43.2 µM -1.79576531965808 0.0754487079244936 no 3047 0.0362659242325841 1052 6793154 SGTC_1506 4226-2149 212 µM -1.79776448488853 0.0752270153291254 no 3048 0.0361071688142393 1052 991114 SGTC_839 0122-0028 230 µM -1.80090998845036 0.0748792082322447 no 3049 0.0358585341977783 1035 759448 SGTC_1635 st007035 42.4 µM -1.80891486837645 0.0739996204907857 no 3050 0.0352321150682786 1006 3716403 SGTC_1143 3454-2408 5.08 µM -1.81214659717388 0.0736467586773492 no 3051 0.0349817740164748 1007 X1143 SGTC_624 k048-0052 28 µM -1.81316635087681 0.0735356825405694 no 3052 0.0349030840049646 1060 6835531 SGTC_2704 st078022 71.1 µM -1.81455232994881 0.073384920925614 no 3053 0.0347963669616447 1050 54697681 SGTC_1600 coumarin 106 71.1 µM -1.81719488688591 0.0730981287026725 no 3054 0.0345936388117316 1050 100336 A hepatotoxic, DNA x-linker. SGTC_3060 1327-0027 12.5 µM -1.81821605906247 0.0729875326603851 no 3055 0.0345155582284154 1028 16000455 YPR107C YTH1 SGTC_1330 1469-0054 61.8 µM -1.82147430385759 0.0726355110314592 no 3056 0.0342673946373389 1045 7102664 SGTC_3139 9095020 49.47 µM -1.82174837703011 0.0726059594840252 no 3057 0.034246586946714 1035 25236292 SGTC_363 0455-0021 3.06 µM -1.8268458397221 0.0720580097098694 no 3058 0.0338614757169501 1012 4597466 SGTC_990 3985-0011 41.3 µM -1.82868229692171 0.0718613791541845 no 3059 0.0337236080057948 1029 5399565 YGL099W LSG1 SGTC_1104 tacrolimus 29.8 µM -1.83341592907092 0.0713564437326513 no 3060 0.033370370264144 1039 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_103 0844-0104 51.839 µM -1.83626481412157 0.0710538691902385 no 3061 0.0331592504822871 1023 5375804 SGTC_928 2764-0428 58.7 µM -1.83634390028053 0.0710454836810913 no 3062 0.0331534054477768 1055 662578 SGTC_3149 9097855 49.47 µM -1.83736154753668 0.0709376502936108 no 3063 0.033078269716001 1047 25236625 YMR079W SEC14 SGTC_2778 tioconazole 65.09 nM -1.83944371097365 0.070717408950901 no 3064 0.0329249749674715 1024 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_182 3448-4371 550.524 µM -1.84716978120944 0.0699047721044743 no 3065 0.0323612687727692 1050 3491403 SGTC_2884 9058502 51.95 µM -1.84771849961458 0.0698473317206873 no 3066 0.032321538161401 1053 6471554 SGTC_1067 clotrimazole 1.36 µM -1.8478118856617 0.0698375595952478 no 3067 0.0323147804430592 1042 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2313 7726885 200 µM -1.84976455677289 0.0696334686459714 no 3068 0.0321737456777667 1046 726423 SGTC_2429 5902844 64.44 µM -1.85082957664596 0.0695223476770516 no 3069 0.0320970373175054 1053 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_197 4544-0043 41.561 µM -1.85155078448036 0.0694471765983246 no 3070 0.0320451779112341 1059 896523 SGTC_2981 9013952 38.96 µM -1.85263311804469 0.0693344830709717 no 3071 0.0319674811180852 1039 2996344 SGTC_384 k007-0144 5.16 µM -1.8546891795607 0.0691207921587582 no 3072 0.0318203124082035 1057 6824886 SGTC_2076 5212012 200 µM -1.85881240724027 0.0686937860054098 no 3073 0.0315268665950705 1047 604802 SGTC_3126 9127922 49.47 µM -1.86215501236459 0.0683491173884164 no 3074 0.0312906217952605 1018 45595682 SGTC_1179 1021-1431 9.29 µM -1.86426562817909 0.0681321721192767 no 3075 0.0311422055764606 1060 2840958 SGTC_1606 st000094 49.2 µM -1.86694660254429 0.0678573679065323 no 3076 0.0309545225149145 1050 1242210 SGTC_507 nimesulide 162 µM -1.86859775262457 0.0676885487776357 no 3077 0.0308393993403597 1059 4495 A COX2 inhibitor. SGTC_2041 5107442 45.335 µM -1.87962857039079 0.0665690332089926 no 3078 0.0300793583378204 1064 793005 SGTC_977 1348-1378 135 µM -1.87989662506031 0.0665420078534019 no 3079 0.0300610839827827 1043 X977 SGTC_257 daunorubicin 18.5 µM -1.88062191763044 0.0664689262085043 no 3080 0.0300116840443903 1043 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_740 k014-0057 261 µM -1.88690535813748 0.0658383951696538 no 3081 0.0295865281557278 1055 4012779 SGTC_1396 3511-0007 98.6 µM -1.88758203433884 0.065770769460675 no 3082 0.0295410419092462 1056 X1396 SGTC_2186 6124449 200 µM -1.88884110052698 0.0656450841329796 no 3083 0.0294565618282095 1051 3834182 YLR033W RSC58 SGTC_2651 TUB2.036 5 µM -1.88899075096024 0.0656301577821371 no 3084 0.0294465340214363 1029 15992207 YFL037W TUB2 SGTC_1996 st072960 66.8 µM -1.8901268082613 0.065516931580156 no 3085 0.0293705012497835 1059 1719405 SGTC_2299 7976368 114.88 µM -1.89978212073319 0.0645607314964921 no 3086 0.0287308591010409 1047 2979718 SGTC_2601 securinine 100 µM -1.90254781097757 0.0642888422569818 no 3087 0.0285497872887714 1039 442872 A GABA receptor antagonist. SGTC_314 1671-0008 2.74 µM -1.90966678857425 0.0635930835577225 no 3088 0.0280880648603313 1042 3913060 SGTC_1320 1313-0481 95.3 µM -1.91330886335367 0.0632394056128956 no 3089 0.0278542618623692 1064 6813365 YLR208W SEC13 SGTC_1057 3448-5381 134 µM -1.92265751972357 0.0623385782724887 no 3090 0.0272615375616962 1008 5497911 SGTC_1346 1488-2224 62.4 µM -1.92521462862175 0.0620939289620896 no 3091 0.0271012563642473 1052 3722427 SGTC_2457 5731572 11.68 µM -1.93071634201408 0.0615700971447403 no 3092 0.0267590704200378 1062 2865357 SGTC_41 0478-0632 82.643 µM -1.9313367676619 0.0615112420488677 no 3093 0.026720709643085 1039 3750424 SGTC_150 3970-0969 77.2 µM -1.93324918210707 0.0613301021674985 no 3094 0.0266027543544083 1054 6615640 SGTC_2894 9048625 32.47 µM -1.93828898880228 0.0608547383185494 no 3095 0.0262939875220217 1055 4092861 SGTC_1370 2001-0092 44.6 µM -1.93982194097553 0.0607107203095385 no 3096 0.0262006665960802 1050 790957 SGTC_445 e6 berbamine 66 µM -1.94767797528091 0.0599768399783619 no 3097 0.0257267535404678 1047 6610268 A calcium/calmodulin antagonist. SGTC_3199 9111318 49.47 µM -1.95277159822261 0.0595047382073632 no 3098 0.0254233326950405 1051 8548020 SGTC_3086 9117350 49.47 µM -1.9573446668687 0.0590833698842348 no 3099 0.0251534796562797 1060 2679265 SGTC_3343 9148379 18.9835 µM -1.95976508430267 0.0588612987103692 no 3100 0.0250116270043544 1028 1955036 SGTC_3015 9080845 49.47 µM -1.96456657032012 0.0584227054390464 no 3101 0.02473221216034 1067 5296973 SGTC_138 0850-0259 40.9225 µM -1.96591462785661 0.0583000292562363 no 3102 0.0246542365296531 1045 6813004 SGTC_1937 st074714 47.2 µM -1.96808404034438 0.0581030329067978 no 3103 0.0245291844226892 1057 17250970 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.97174852677868 0.0577714627933373 no 3104 0.0243191604932698 1074 65057 A dermal irritant. YDR527W RBA50 SGTC_2305 7443522 69.23 µM -1.98013862327388 0.0570179126750694 no 3105 0.0238439771192102 1046 5415886 SGTC_3034 9090421 49.47 µM -1.98091776202858 0.0569483294340585 no 3106 0.0238002484152016 1061 17173761 SGTC_1696 st025591 34.7925 µM -1.98336328729915 0.0567303589598578 no 3107 0.02366343242575 1055 2787147 SGTC_1499 4480-0877 67.3 µM -1.98922060197162 0.0562109664630664 no 3108 0.0233384294420023 1062 2861909 SGTC_2077 5212015 200 µM -1.9906439629452 0.056085319093384 no 3109 0.0232600216971383 1057 780900 SGTC_2292 7671323 168.05 µM -1.99205959492674 0.0559605737969889 no 3110 0.0231822597577051 1062 937504 SGTC_245 methotrexate 289.6 µM -1.99395129610153 0.0557942191086566 no 3111 0.0230786886557026 1058 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2950 9072895 21.46 µM -1.99419080835694 0.0557731844511439 no 3112 0.0230656031343386 1042 17332245 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.99460087987732 0.0557371853153482 no 3113 0.0230432137780426 1070 689007 SGTC_2627 acetyl isogambogic acid 100 µM -1.99470396071785 0.0557281389950409 no 3114 0.023037588581608 1060 6857789 A caspase activator and apoptosis inducer. SGTC_601 0986-0029 62.9 µM -1.996058622132 0.0556093622578488 no 3115 0.0229637711230895 1044 24747981 SGTC_658 3253-0951 102 µM -2.00561890035521 0.0547767888447451 no 3116 0.0224484619077737 1068 1184878 SGTC_875 0709-0210 25.7 µM -2.01090008200326 0.0543211109630211 no 3117 0.0221680058521334 1071 6251364 SGTC_1856 st057054 55.7 µM -2.01247680500014 0.0541856489754483 no 3118 0.0220848496739008 1058 1266018 SGTC_393 acivicin 6.25 µM -2.01369980082842 0.0540807611733616 no 3119 0.0220205304779519 1010 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_978 1416-0512 87.4 µM -2.01388219692871 0.0540651321146175 no 3120 0.0220109515558056 1081 6814003 SGTC_785 1270-0111 65.3 µM -2.01918407554296 0.0536123879640131 no 3121 0.0217340454153103 1057 6741994 SGTC_2404 5161160 200 µM -2.02602612496829 0.053032568502959 no 3122 0.021381053769858 1049 2831543 SGTC_1731 st035964 63 µM -2.03444374259203 0.0523260645976244 no 3123 0.0209534376550798 1057 6739575 SGTC_3175 9106517 49.47 µM -2.03592328975298 0.0522026596498969 no 3124 0.0208790293823149 1070 41468073 SGTC_2185 6113692 200 µM -2.04365498568844 0.0515615358505453 no 3125 0.0204938215586327 1060 874150 SGTC_1983 st071813 46.9 µM -2.04460114847935 0.0514835104396546 no 3126 0.0204470980962172 1062 11838595 SGTC_1494 4358-1428 177 µM -2.05142647704489 0.0509234372966367 no 3127 0.0201127164015432 1066 1564571 SGTC_3143 9086658 49.47 µM -2.05985497881181 0.050238515969331 no 3128 0.0197062033960385 1043 25236626 SGTC_937 3122-0005 46.7 µM -2.06248455671679 0.0500263390841971 no 3129 0.0195808131782838 1067 759535 SGTC_512 prima-1 270 µM -2.06502606790567 0.049821947819799 no 3130 0.019460266929246 1071 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1728 st035614 33.7865 µM -2.07304252260694 0.0491816166271937 no 3131 0.0190841611843399 1058 15945546 SGTC_477 mead ethanolamide 10 µM -2.07733512468552 0.0488414477642365 no 3132 0.0188853196790365 1085 16061185 SGTC_783 0848-0141 92.7 µM -2.0788804057831 0.0487194526236539 no 3133 0.0188141720523163 1065 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_749 1000-0129 128 µM -2.07943622803939 0.0486756317893537 no 3134 0.0187886367878668 1073 708470 SGTC_3259 9138485 49.47 µM -2.08306950314459 0.0483899612392747 no 3135 0.0186224443622731 1058 17646153 SGTC_790 1575-0012 79.1 µM -2.08563161040931 0.0481893199086438 no 3136 0.0185060028496984 1044 378741 YLR208W SEC13 SGTC_1393 3470-5649 58.2 µM -2.09963555364683 0.0471043906389312 no 3137 0.0178804563592302 1070 4108395 SGTC_2597 laccaic acid a 100 µM -2.10018453481847 0.0470622615405439 no 3138 0.0178563056304261 1071 5491415 A textile dye. SGTC_2184 6075246 200 µM -2.10222944081571 0.0469056001854341 no 3139 0.0177665910090108 1070 2267320 SGTC_2685 mycophenolic acid 18.85 µM -2.10243998092314 0.046889494369595 no 3140 0.0177573760142378 1060 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_689 0833-0039 98 µM -2.10315316735166 0.0468349702668414 no 3141 0.017726191311428 1058 5374726 SGTC_660 4031-1742 102 µM -2.11161816131881 0.0461916861148886 no 3142 0.0173596067750201 1062 6738706 SGTC_1567 st069303 68.4 µM -2.11308615295427 0.0460808537205379 no 3143 0.0172966973199797 1075 5581319 SGTC_1482 3346-2049 8.48 µM -2.11309339029118 0.0460803078360289 no 3144 0.0172963876534947 1080 3826804 SGTC_550 4123-0385 25.7 µM -2.11994443823089 0.0455658849045327 no 3145 0.0170053656091178 1073 5731123 SGTC_2163 5671233 125 µM -2.1199475820724 0.045565649908008 no 3146 0.017005233030387 1055 701023 SGTC_1789 tunicamycin 25 nM -2.1262647163545 0.0450954200458025 no 3147 0.0167406120904726 1044 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2556 citropten 84.59 µM -2.12778615274129 0.0449827540760922 no 3148 0.0166774089894968 1057 2775 A potential DNA crosslinker. SGTC_725 1497-0963 19 µM -2.12895848759483 0.0448960945463921 no 3149 0.0166288475425765 1079 3549977 SGTC_1686 st019653 115.5 µM -2.13377047512566 0.0445417973120536 no 3150 0.0164307869326828 1084 97252 SGTC_3270 9137563 49.47 µM -2.14294386603272 0.0438726198885799 no 3151 0.0160588030310048 1063 17015724 SGTC_2750 bromebric acid 70.15 µM -2.15789765718122 0.0427991809312636 no 3152 0.0154678948494122 1070 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1621 st003705 32.4 µM -2.15965897050113 0.0426741567838034 no 3153 0.0153995398264008 1068 24207032 SGTC_1738 st035555 74 µM -2.16645674244567 0.0421943935321859 no 3154 0.0151381509916481 1066 5331140 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.16830608012283 0.0420646316202004 no 3155 0.0150677030694703 1036 688669 SGTC_3320 9137005 35.139 µM -2.16963168161067 0.0419718174340391 no 3156 0.0150173796621349 1081 4908713 SGTC_1507 4075-3230 155 µM -2.17623587382516 0.0415118815517243 no 3157 0.0147688138770181 1055 659771 SGTC_1875 nocodazole 6 µM -2.17854854541936 0.0413517888038426 no 3158 0.0146826110862401 1074 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3277 9138724 49.47 µM -2.1896174164215 0.040592471406506 no 3159 0.0142759974194068 1084 15943418 SGTC_1558 st069300 45.6 µM -2.18998439832806 0.0405674918234256 no 3160 0.0142626841661166 1069 24208000 SGTC_1803 st050068 52.4 µM -2.19163766001041 0.040455112928124 no 3161 0.0142028401880657 1065 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1882 5615643 20 µM -2.19494277126195 0.0402312088647884 no 3162 0.0140838515952909 1060 2253075 SGTC_221 trifluoperazine 10.304 µM -2.19709713637721 0.0400858045072518 no 3163 0.0140067547982896 1073 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1510 1123-0200 71.5 µM -2.19983943552145 0.0399013367560238 no 3164 0.0139091444791203 1074 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3091 9116372 49.47 µM -2.20202744580251 0.0397546500406742 no 3165 0.0138316849115964 1074 17169793 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.20333441544638 0.0396672386582516 no 3166 0.0137855935021108 1056 6708739 YPR165W RHO1 SGTC_2204 7233102 200 µM -2.20769203058627 0.039376925802783 no 3167 0.0136328743792132 1075 2172480 SGTC_263 alizarin 107.927 µM -2.20925648280311 0.039273121597947 no 3168 0.0135784030980591 1065 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1070 indatraline 8.81 µM -2.21849620120065 0.038664582594686 no 3169 0.0132605091587316 1065 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_280 3448-3607 3.04 µM -2.21885971414184 0.0386407991547202 no 3170 0.0132481349984956 1046 626179 SGTC_1509 1326-1131 80 µM -2.2266465970561 0.0381341856120264 no 3171 0.0129854510621016 1055 768313 SGTC_1775 st081588 35.1725 µM -2.22823837029458 0.03803129486751 no 3172 0.0129323118138271 1048 1426443 YGL099W LSG1 SGTC_1874 staurosporine 7.6 µM -2.22872114080492 0.0380001338263318 no 3173 0.0129162323663589 1065 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_729 4092-0585 94.1 µM -2.23012405403976 0.0379096991904064 no 3174 0.0128696041681905 1069 2169061 SGTC_3118 9124250 49.47 µM -2.24219294753257 0.0371389462385337 no 3175 0.0124744523816922 1067 1504786 SGTC_3240 9133527 49.47 µM -2.25220423324946 0.0365093577298657 no 3176 0.0121546843172694 1079 17617455 SGTC_1306 1185-0270 9.02 µM -2.25636511353281 0.0362502706541066 no 3177 0.0120238872974657 1072 1548076 SGTC_1766 st045414 44.774 µM -2.26361867105245 0.0358022108536184 no 3178 0.0117987892407657 1068 253960 SGTC_1033 k072-0102 21.3 µM -2.27745496060706 0.0349601139695937 no 3179 0.0113795356380491 1066 5965931 SGTC_506 n9-isopropylolomoucine 153 µM -2.27942899830011 0.0348413071046126 no 3180 0.0113207880830556 1080 6610355 SGTC_3127 9126946 49.47 µM -2.29118543805328 0.0341405967897604 no 3181 0.0109763454077029 1069 27243249 SGTC_2937 9044753 11.33 µM -2.29669106478908 0.0338164550091188 no 3182 0.0108181997661637 1065 6465530 YGL099W LSG1 SGTC_528 3492-0019 172 µM -2.29671460488565 0.033815074549341 no 3183 0.0108175278725639 1069 2869262 SGTC_3333 9141820 12.094 µM -2.29681104524026 0.0338094194902826 no 3184 0.0108147756013646 1072 1939433 SGTC_2679 rapamycin 1 nM -2.29732718758728 0.0337791672147905 no 3185 0.0108000559880255 1029 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.30460830608847 0.0333547724668004 no 3186 0.0105942601835803 1059 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1080 nisoldipine 24.4 µM -2.30674823828951 0.0332308803380633 no 3187 0.0105344296833237 1079 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1374 2889-5571 141 µM -2.30744400546768 0.03319068040007 no 3188 0.0105150402084522 1073 2853281 SGTC_2436 5633522 8.09 µM -2.30838906448809 0.0331361410817521 no 3189 0.0104887533366748 1074 5724242 SGTC_3303 9125618 40.5795 µM -2.30978233728989 0.0330558700432061 no 3190 0.0104501038218321 1066 22695467 SGTC_3339 9145883 14.936 µM -2.31178470967273 0.0329407874369238 no 3191 0.0103947752251667 1050 2030670 SGTC_2913 7966556 36.57 µM -2.32225279196149 0.0323445174274545 no 3192 0.0101096639361854 1041 2976516 SGTC_3332 9141069 11.198 µM -2.33203184643255 0.0317955688138193 no 3193 0.00984950793581266 1078 17332883 SGTC_467 ro 31-8220 72.8 µM -2.33993372792123 0.0313576382580628 no 3194 0.00964358099614879 1066 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2418 pentamidine 31.67 µM -2.34583427233135 0.0310338866317879 no 3195 0.00949227334959101 1043 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3244 9134489 49.47 µM -2.35354066084381 0.030615221621422 no 3196 0.0092977869959092 1080 16584271 SGTC_2246 7293507 91.5585 µM -2.35671097833551 0.0304443510306264 no 3197 0.00921879539140026 1079 887656 SGTC_2718 lomofungin 53.02 µM -2.36269731636685 0.0301238597906334 no 3198 0.00907124029904541 1074 5351222 A RNA synthesis inhibitor. SGTC_2008 4012253 172 µM -2.3700942754963 0.0297317163565584 no 3199 0.00889177503247979 1062 603940 SGTC_1800 st050079 29.0735 µM -2.37625917706125 0.0294081340987699 no 3200 0.00874458678486724 1068 3645560 SGTC_2999 9069765 71.4286 µM -2.38682195170631 0.0288605160036614 no 3201 0.0084973598379888 1072 2097066 SGTC_297 0986-0032 24 µM -2.3894673990652 0.0287247003388758 no 3202 0.00843641063333053 1077 2847425 SGTC_1085 doxorubicin 7.67 µM -2.39353521136878 0.0285168985026928 no 3203 0.0083434397752104 1075 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3032 9089427 49.47 µM -2.40117775560838 0.028129865265558 no 3204 0.00817119788829766 1041 17173707 SGTC_1829 berberine 14.4 µM -2.40259856494907 0.0280583970174146 no 3205 0.00813952343560705 1033 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.40330001769415 0.0280231689737542 no 3206 0.00812392559548521 1070 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1712 st032288 53.4 µM -2.40577238833927 0.0278992962692199 no 3207 0.00806915802422031 1082 2883011 SGTC_2009 4012297 12.05 µM -2.40923038252708 0.0277268064712623 no 3208 0.00799310153211091 1069 45595307 SGTC_2288 7946289 167.31 µM -2.41416371863155 0.0274822635109277 no 3209 0.00788568697093837 1077 1246052 SGTC_1553 gossypol 38.6 µM -2.41662930154478 0.0273607213676495 no 3210 0.0078324807100516 1082 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_810 3825-7150 143 µM -2.42412568518184 0.0269939338653572 no 3211 0.00767264679605988 1054 22330411 YGL099W LSG1 SGTC_1405 3909-7894 12 µM -2.42692577509743 0.0268579863369279 no 3212 0.00761368543473088 1049 7104060 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -2.4277057489578 0.0268202196764248 no 3213 0.00759733276625955 1073 5377381 SGTC_2918 7977171 22.06 µM -2.43378955173578 0.0265271586171342 no 3214 0.00747083973684664 1083 2236483 SGTC_589 1227-0070 34.1 µM -2.43639687312441 0.0264023836679704 no 3215 0.00741719936063737 1083 2841384 SGTC_2688 kanamycin b 96.69 µM -2.43877267997339 0.0262891154579591 no 3216 0.00736861774198827 1056 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2816 7982706 58.44 µM -2.45672432344539 0.0254463230763352 no 3217 0.00701051172755477 1072 2981853 SGTC_877 0771-0151 33.1 µM -2.45927348542524 0.0253285003336763 no 3218 0.00696092597857051 1085 6166523 SGTC_1941 st076221 61.8 µM -2.46020552429106 0.025285535579386 no 3219 0.00694287360909473 1058 2828568 SGTC_1406 3909-7906 11.9 µM -2.46062314810592 0.0252663039434793 no 3220 0.00693479820255369 1052 X1406 SGTC_2552 juarezic acid 87.02 µM -2.46128482169118 0.0252358588731439 no 3221 0.00692202069169022 1074 1549512 SGTC_866 0495-0101 262 µM -2.4614815748418 0.0252268117555231 no 3222 0.00691822522358521 1064 635694 SGTC_252 miconazole 1.30953 nM -2.46309677428443 0.0251526442242073 no 3223 0.00688713660626963 1061 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_178 4092-0806 87.505 µM -2.4729007261914 0.0247063723763229 no 3224 0.00670106831211551 1058 2169044 SGTC_964 1287-0107 19.4 µM -2.47945664612453 0.024411670992273 no 3225 0.00657913625990304 1079 51516812 YPR165W RHO1 SGTC_1924 st058459 75.1 µM -2.48346132421207 0.024233109000374 no 3226 0.0065056231288271 1076 688683 SGTC_809 3998-0021 90 µM -2.49090209768126 0.0239042492756509 no 3227 0.00637096124371382 1074 715485 SGTC_3142 9086498 49.47 µM -2.50102099879834 0.0234630502625702 no 3228 0.00619179177593785 1051 25236367 SGTC_1569 carminic acid 40.6 µM -2.50511463769475 0.0232865183091095 no 3229 0.00612058553621549 1080 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1818 st052136 56.3 µM -2.50764290675902 0.0231780499836776 no 3230 0.00607697120552556 1066 674169 SGTC_2586 curcumin 80 µM -2.50912670531453 0.023114590048933 no 3231 0.00605150313694585 1088 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2640 pentamidine 10.38 µM -2.52519007124087 0.022436899091416 no 3232 0.00578178642060485 1033 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2298 7976326 193.81 µM -2.53970062164173 0.0218391999898374 no 3233 0.00554736966953939 1091 2235818 SGTC_102 gallobenzophenone 83.616 µM -2.54202307493715 0.0217447962318907 no 3234 0.00551064485809451 1069 70837 SGTC_256 clotrimazole 625 nM -2.54837769784379 0.0214882520460821 no 3235 0.00541126136601473 1078 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1919 st067113 52.3 µM -2.5494231131662 0.0214462933335234 no 3236 0.00539506503717594 1069 1268243 SGTC_2511 berberine 10.47 µM -2.5509020400595 0.0213870535432724 no 3237 0.00537222604139119 1075 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2662 daunorubicin 22.37 µM -2.56282949504064 0.0209143265781008 no 3238 0.00519115106538637 1061 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2389 9091542 195.52 µM -2.56604786403745 0.0207882969880053 no 3239 0.00514323163867176 1079 3626624 YOL127W RPL25 SGTC_3235 9132602 49.47 µM -2.56674995725804 0.0207608890026142 no 3240 0.00513283038769314 1084 4912240 SGTC_2036 5160441 105 µM -2.56755571846255 0.0207294717897479 no 3241 0.00512091641129905 1074 134534 YIL048W NEO1 SGTC_3107 9121808 49.47 µM -2.57133762429926 0.0205825499708182 no 3242 0.00506532548132638 1078 662681 SGTC_2645 abamectin 100 µM -2.57722625712862 0.0203555412131277 no 3243 0.00497983671545087 1027 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1936 st074407 74.3 µM -2.59774447148129 0.0195810664852561 no 3244 0.00469191478071878 1081 809813 SGTC_609 0986-0026 86.3 µM -2.59904664330843 0.0195327711153907 no 3245 0.00467415349866688 1078 2848610 SGTC_1072 oxiconazole 14.9 nM -2.60909771484967 0.019163386958319 no 3246 0.00453906577485602 1070 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1754 st042065 16.137 µM -2.61711365563668 0.0188730675582773 no 3247 0.00443384046638329 1062 1126236 YIL048W NEO1 SGTC_951 1171-0579 82.7 µM -2.61722215891887 0.0188691636222677 no 3248 0.00443243121593605 1072 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2282 7944268 200 µM -2.62014392992229 0.0187642966626231 no 3249 0.00439463313523795 1079 2970414 SGTC_207 4185-0010 4.486 µM -2.62431462145665 0.0186154634998959 no 3250 0.0043411770930338 1081 3761753 SGTC_2444 5485484 36.41 µM -2.64084516114699 0.0180354090531039 no 3251 0.0041349752756216 1085 6790631 SGTC_2705 st078069 42.8 µM -2.64273635382744 0.0179700403003476 no 3252 0.0041119522204751 1089 1530061 SGTC_3039 9090270 49.47 µM -2.64491879645127 0.0178948557403186 no 3253 0.00408552616349577 1080 17173750 SGTC_128 0906-2981 13.371 µM -2.65328577641001 0.0176090964206109 no 3254 0.00398561755640146 1080 6740226 SGTC_649 1123-0311 367 µM -2.65992020517891 0.0173852863596988 no 3255 0.00390795830379931 1083 693629 YIL048W NEO1 SGTC_3328 9140624 29.0385 µM -2.66521052787007 0.0172085643837887 no 3256 0.0038470069586476 1086 4904392 SGTC_2997 9067075 71.4286 µM -2.66798962624406 0.0171163457471357 no 3257 0.00381533070588386 1079 27209819 SGTC_3216 9129716 49.47 µM -2.67373576336109 0.0169270107902953 no 3258 0.00375057646206643 1080 8056934 SGTC_2179 6298986 200 µM -2.67703121861887 0.0168192358466018 no 3259 0.0037138856839921 1051 738374 SGTC_466 geldanamycin 89.2 µM -2.67960408474257 0.0167355010210289 no 3260 0.00368546417471015 1089 5288382 HSP90 inhibitor. SGTC_291 SEC14.278 35.5 µM -2.6820763420524 0.0166553767819366 no 3261 0.00365833803520398 1088 1068044 SGTC_726 3448-4391 34.2 µM -2.71355056406497 0.0156636698574178 no 3262 0.00332832042862557 1083 1356692 SGTC_2183 6420625 130.508 µM -2.71451209221591 0.0156341886183565 no 3263 0.00331867385748757 1080 2897619 SGTC_2411 st077133 39.94 µM -2.72128678644449 0.0154278173507712 no 3264 0.00325141595557398 1076 1403142 YNL221C POP1 SGTC_525 k781-2675 26.7 µM -2.74663891822105 0.0146761593737815 no 3265 0.00301046907264152 1070 3651118 YDL195W SEC31 SGTC_1612 st002233 45.4 µM -2.7736722071638 0.0139095797736922 no 3266 0.002771374798483 1083 1035021 SGTC_1383 3049-0032 20.7 µM -2.79801340128864 0.0132491291066735 no 3267 0.00257089896164611 1082 712864 SGTC_135 0933-0004 26.348 µM -2.80466248655962 0.0130734994020756 no 3268 0.00251846463248915 1078 21230617 YGL099W LSG1 SGTC_3125 9127534 49.47 µM -2.80801735022163 0.0129856500076526 no 3269 0.00249237705523581 1081 1639235 SGTC_3152 9099253 49.47 µM -2.81025541590872 0.0129273289421942 no 3270 0.00247510989345158 1073 25236131 SGTC_3249 9135183 49.47 µM -2.81764722255267 0.0127363146637036 no 3271 0.00241884652585154 1065 4902779 SGTC_3186 9110464 49.47 µM -2.81771207898339 0.0127346495516879 no 3272 0.0024183580287644 1090 17018021 SGTC_2891 9063876 19.48 µM -2.82482474803559 0.0125531794841154 no 3273 0.0023653241329481 1092 6472478 SGTC_1130 3454-2858 15.9 µM -2.83126685756491 0.0123907542044672 no 3274 0.00231820103099222 1082 715628 YIL048W NEO1 SGTC_3307 9126885 69.2785 µM -2.83828497015167 0.0122158808718564 no 3275 0.00226783342330098 1090 24824909 SGTC_3316 9136639 10.545 µM -2.84316637720894 0.0120955135747852 no 3276 0.00223338731246733 1083 4903665 SGTC_2890 9046729 58.44 µM -2.84923789648334 0.0119472359654312 no 3277 0.00219120490638391 1086 903329 SGTC_1403 3909-7815 62.9 µM -2.88184809579726 0.0111775168768694 no 3278 0.00197675139011476 1091 6615483 SGTC_1693 xanthone 101.9 µM -2.88611577165735 0.0110800457672581 no 3279 0.00195014328732112 1093 7020 An insecticide. SGTC_2100 5377183 190 µM -2.88799045274668 0.0110374634211351 no 3280 0.0019385582017664 1079 2844202 SGTC_610 4215-0184 155 µM -2.88905142957622 0.0110134270537385 no 3281 0.00193202935385563 1075 5605015 SGTC_439 amiodarone 34.4 µM -2.89949330475173 0.010779286044627 no 3282 0.00186883163720062 1085 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2916 7875993 68.79 µM -2.93092202166235 0.0101005099902191 no 3283 0.00168978801262278 1090 1299250 SGTC_1780 st038448 24.544 µM -2.93197419680561 0.0100784459951788 no 3284 0.00168407365051446 1084 728868 YDL195W SEC31 SGTC_943 3253-1379 105 µM -2.93317427649566 0.0100533318109167 no 3285 0.00167757750282489 1077 668464 SGTC_2307 7538926 6.34 µM -2.93495384032212 0.0100161912483312 no 3286 0.00166798655140742 1081 96582 SGTC_699 0375-0592 111 µM -2.9390393799397 0.00993137636666648 no 3287 0.0016461561988088 1089 762578 SGTC_1883 5-benzylidenerhodanine 20 µM -2.94072523777652 0.00989656150236668 no 3288 0.00163722421793986 1085 1273210 SGTC_187 1488-2104 32.728 µM -2.95363011420995 0.00963357329774654 no 3289 0.00157030091657326 1091 2852859 SGTC_690 glyoxal 20.3 µM -2.98438838782833 0.00903124353948525 no 3290 0.00142072922369208 1086 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_443 clozapine 122 µM -2.98819549425853 0.00895903358209476 no 3291 0.00140314993935586 1094 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1133 3473-0247 50 µM -2.99895815528545 0.00875762575974149 no 3292 0.00135452255192112 1075 711311 SGTC_3098 9119039 49.47 µM -3.02694703066528 0.00825232782987848 no 3293 0.00123518621723728 1091 17161528 SGTC_305 1682-2595 20.8 µM -3.02728181654796 0.00824644207348513 no 3294 0.00123381891201816 1091 226033 SGTC_1381 2324-0066 62.1 µM -3.03899149392345 0.00804288476699989 no 3295 0.0011868577822161 1088 10885928 SGTC_3105 9121040 49.47 µM -3.07033309031227 0.00751962991498029 no 3296 0.0010691008037172 1088 41448907 SGTC_2382 9035899 200 µM -3.07621646154171 0.00742481971392358 no 3297 0.0010482279398173 1091 6462679 SGTC_1230 0170-0365 3.77 µM -3.09910713930665 0.00706588522241207 no 3298 0.000970524067563218 1084 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1959 st077091 55.8 µM -3.10158199772338 0.00702801102640508 no 3299 0.000962447767046035 1087 821356 YKL052C ASK1 SGTC_1597 7-benzyloxygramine 47.5 µM -3.10177094072015 0.00702512689727986 no 3300 0.000961833724840817 1079 260807 SGTC_3037 9091026 49.47 µM -3.10201045078218 0.007021472386266 no 3301 0.000961055862747274 1089 25236398 YIL048W NEO1 SGTC_2322 7413319 38.22 µM -3.10522963032563 0.00697251583884632 no 3302 0.000950656772541642 1074 1840400 SGTC_1948 st076329 66.6 µM -3.11844816256731 0.00677463620984924 no 3303 0.000909030600377843 1092 24208413 SGTC_183 3914-0051 30.55 µM -3.13297109482258 0.00656296513321336 no 3304 0.00086523241399107 1089 1596232 SGTC_2396 5342950 42.78 µM -3.15818245995641 0.00620936997440759 no 3305 0.000793780795897809 1073 1886677 SGTC_2200 6600604 21.907 µM -3.21761499154002 0.00544176668542909 no 3306 0.000646306003129176 1093 2904777 SGTC_2912 7964298 10.93 µM -3.22121203346549 0.00539813951066937 no 3307 0.000638248353276572 1084 2975850 SGTC_2739 tacrine 100.86 µM -3.22440308870133 0.00535969695473277 no 3308 0.000631177875204339 1027 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1282 0886-0010 32.4 µM -3.25211476857123 0.00503595864870846 no 3309 0.000572748790690432 1090 2836211 YNL267W PIK1 SGTC_3329 9141233 27.5565 µM -3.27054195680683 0.00483044049552897 no 3310 0.000536708088072353 1083 4909101 YNL103W MET4 SGTC_1687 st020778 55.3625 µM -3.28180410987501 0.0047085466340079 no 3311 0.000515726167747987 1092 4259299 SGTC_2837 9008476 45.46 µM -3.30893098831808 0.00442613612956699 no 3312 0.000468264592724912 1087 2992805 SGTC_3222 9128301 49.47 µM -3.31602954739911 0.00435477828658957 no 3313 0.000456530872838786 1076 4911358 SGTC_1827 berberine 7.24 µM -3.33163711395532 0.00420148780473074 no 3314 0.000431683785054579 1072 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3188 9110789 49.47 µM -3.33234724382583 0.00419462945648034 no 3315 0.000430583660275946 1089 849217 SGTC_1922 5578187 25 µM -3.34241571414664 0.00409846117220225 no 3316 0.000415262869346298 1087 1350412 SGTC_618 k072-0232 33.2 µM -3.4004010126678 0.00358204949776465 no 3317 0.000336435466903816 1081 5872756 YGL099W LSG1 SGTC_852 0418-0143 439 µM -3.49958821437285 0.00283260515584019 no 3318 0.000232988696303133 1082 5369229 SGTC_1844 rapamycin 4 nM -3.50336611180421 0.00280708578457263 no 3319 0.000229708773455285 1079 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3319 9138450 16.7555 µM -3.50639805710696 0.00278675548950453 no 3320 0.000227107694653843 1093 2029690 SGTC_255 tunicamycin 200.472 nM -3.51982261496836 0.00269832618022126 no 3321 0.000215917750844801 1085 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2286 7945697 125 µM -3.55592965453662 0.00247291666708595 no 3322 0.000188322427920128 1086 1245733 SGTC_1717 st033143 58.0435 µM -3.60963400921936 0.00216905871634657 no 3323 0.000153314666179097 1089 674616 SGTC_3287 9117173 37.0625 µM -3.62037735961464 0.00211249822761908 no 3324 0.000147086831374662 1084 2789709 SGTC_2619 obliquin 87.91 µM -3.63694493526147 0.00202789358961033 no 3325 0.000137945440542449 1090 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1283 0922-0125 16.4 µM -3.67063347918557 0.00186527330847055 no 3326 0.000120975039480687 1092 3360884 SGTC_1716 st033144 30.6155 µM -3.7747600735683 0.0014347481439858 no 3327 8.00808690321028e-05 1089 674617 SGTC_1750 st081859 2.357 µM -3.86584759440754 0.00113473502354059 no 3328 5.53520280641763e-05 1088 5291695 SGTC_2415 st077333 57.7 µM -3.92841352676893 0.000963230510245594 yes 3329 4.27540430520951e-05 1091 2766255 SGTC_1855 st056195 39.6 µM -3.93352334829608 0.000950332358108619 yes 3330 4.18548517582698e-05 1091 4028379 SGTC_97 0535-0701 19.132 µM -3.98237084323577 0.000834798661775004 yes 3331 3.41156027274226e-05 1092 2832013 YGL099W LSG1 SGTC_1269 0831-0796 3.05 µM -3.99919442730915 0.000798099575414957 yes 3332 3.17792256807797e-05 1083 927758 SGTC_2038 4100038 30.985 µM -4.00055383201581 0.000795199983938344 yes 3333 3.15972044120632e-05 1086 3596803 SGTC_2201 6605497 169.863 µM -4.00997615364528 0.000775367362610396 yes 3334 3.03624401478109e-05 1095 670741 SGTC_2338 7999974 200 µM -4.16839202226332 0.000503266784676906 yes 3335 1.53378008973133e-05 1087 315925 SGTC_2021 4019055 173 µM -4.17951927491975 0.000487954727159646 yes 3336 1.46062980165965e-05 1092 44827708 YER133W GLC7 SGTC_1884 5633444 25 µM -4.21811445447519 0.000438124938737684 yes 3337 1.23176884136278e-05 1091 5724239 SGTC_3018 9082602 49.47 µM -4.22438199312889 0.00043049301283955 yes 3338 1.19798678127796e-05 1087 17332089 SGTC_500 h-89 112 µM -4.35615429346109 0.000295969481091554 yes 3339 6.61837434044705e-06 1095 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2991 9074669 71.4286 µM -4.46511490433353 0.000215490794454592 yes 3340 4.0012895672234e-06 1087 17333109 SGTC_2896 9052656 71.43 µM -4.63074806083131 0.000131294591542265 yes 3341 1.82173493026652e-06 1091 6469436 SGTC_1927 st060202 13.8 µM -4.74815928846791 9.15273271549095e-05 yes 3342 1.0263817001328e-06 1095 688887 SGTC_3219 9131112 49.47 µM -4.84319125947008 6.79497947649524e-05 yes 3343 6.38850955562144e-07 1086 17612988 YMR079W SEC14 SGTC_2612 dictamnine 15.46 µM -4.91705371033686 5.37123914581157e-05 yes 3344 4.39282263993718e-07 1091 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2724 maprotiline 69.64 µM -4.93688305484342 5.0399585683325e-05 yes 3345 3.96905191283085e-07 1090 4011 A tricyclic antidepressant. SGTC_2584 androsterone 48.74 µM -5.12658098204894 2.70974014933474e-05 yes 3346 1.47525588546254e-07 1092 2754130 A steroid. SGTC_1619 st003326 88.7 µM -5.56767507258632 5.90344431607469e-06 yes 3347 1.29080323747522e-08 1093 2849032 SGTC_2053 5265679 138 µM -5.57704609378812 5.70834200125829e-06 yes 3348 1.22318531945903e-08 1093 764595 SGTC_2330 7979373 200 µM -5.7626436850057 2.90295581513747e-06 yes 3349 4.14032469081832e-09 1095 1863007 SGTC_1786 berberine 21.6 µM -5.85929539930652 2.02506198706959e-06 yes 3350 2.32417597726558e-09 1090 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2986 9022445 71.43 µM -6.35759359391955 2.89913133393321e-07 yes 3351 1.02469402913724e-10 1094 6459286 SGTC_2926 9010726 65.15 µM -6.80772917936614 4.41616978827891e-08 yes 3352 4.95756426584607e-12 1095 2994293 SGTC_457 grayanotoxin iii 135 µM -7.51562204378217 1.79671042682529e-09 yes 3353 2.83204847465451e-14 1093 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_778 3456-2434 196 µM -9.69694475250887 1.42593515044998e-14 yes 3354 1.55330979726292e-22 1094 5539063 SGTC_2049 5262831 67.185 µM -9.88845452237109 4.43864983967766e-15 yes 3355 2.33592183298371e-23 1095 763417 SGTC_2057 5236571 38.335 µM -12.744866007109 8.91851649712729e-24 yes 3356 1.66481194793933e-37 1095 54684039 YBR257W POP4