SGTCid condition conc unit YPR146C|YPR146C.score YPR146C|YPR146C.strain.pval YPR146C|YPR146C.strain.significant YPR146C|YPR146C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_64 000l-0018 272.079 µM 22.0420229873001 6.79416146650839e-115 yes 1 5.69657032553035e-108 8 6811119 SGTC_67 0335-0847 266 µM 14.729632709297 1.36328421433727e-52 yes 2 2.07980199104523e-49 10 4552207 YOR254C SEC63 SGTC_86 0417-1630 471.922 µM 13.8214890391598 1.43337244241048e-46 yes 3 9.45584895891365e-44 21 3634867 SGTC_142 0335-0849 62.6745 µM 13.6017346888469 3.60270276240629e-45 yes 4 1.95523566986158e-42 19 3889043 YPR107C YTH1 SGTC_137 0438-0332 85.389 µM 13.3961718820389 7.02114811587194e-44 yes 5 3.18315858505317e-41 17 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1750 st081859 2.357 µM 12.1947902587171 9.92306022221661e-37 yes 6 1.6567803418548e-34 30 5291695 SGTC_1294 1000-1494 117 µM 11.7694094231904 2.34282159070081e-34 yes 7 2.80579877008458e-32 10 712797 YDL207W GLE1 SGTC_794 k038-0031 316 µM 10.4016829985574 2.74348202155691e-27 yes 8 1.21796132895699e-25 14 6624242 SGTC_36 0335-0881 14.2 µM 9.46713310801603 5.97056829467248e-23 yes 9 1.43814714424121e-21 21 23828853 SGTC_3060 1327-0027 12.5 µM 9.00627950525879 5.86401094076641e-21 yes 10 1.0658271300407e-19 9 16000455 YPR107C YTH1 SGTC_3059 1327-0034 3 µM 8.41612019240358 1.50614822698708e-18 yes 11 1.94579021086776e-17 17 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_158 k038-0087 26.446 µM 7.86999336203501 1.84673866245111e-16 yes 12 1.77330034573026e-15 50 X158 SGTC_103 0844-0104 51.839 µM 7.69168498299286 8.29698497750225e-16 yes 13 7.26048959240695e-15 49 5375804 SGTC_107 0358-0022 2.6945 µM 5.91652263232413 4.25334535131439e-10 yes 14 1.6440962265234e-09 16 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_576 1073-0113 22.7 µM 5.73204512068997 1.38169768498782e-09 yes 15 4.96134331156928e-09 23 5439563 SGTC_1861 st057647 17.4 µM 5.54918623003777 4.29036684967011e-09 yes 16 1.43501168087187e-08 3 688668 SGTC_367 0335-0881 7.1 µM 5.52446329883333 4.98736942446359e-09 yes 17 1.65247154879154e-08 29 23828853 SGTC_3063 1327-0034 4 µM 5.4873609403497 6.24409507349162e-09 yes 18 2.03991479530631e-08 25 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3282 9108498 15.4605 µM 5.33751270160873 1.52530961136244e-08 yes 19 4.71151518017487e-08 11 16459645 SGTC_58 0957-0393 9 µM 5.27783532557192 2.16287166198095e-08 yes 20 6.53594265247583e-08 258 6997992 SGTC_2782 7736369 71.43 µM 5.15832592141311 4.30497607144913e-08 yes 21 1.24583808120651e-07 16 2950836 YOL077C BRX1 SGTC_852 0418-0143 439 µM 4.93802725350216 1.47323313622455e-07 yes 22 3.94584079863951e-07 42 5369229 SGTC_1200 1643-0193 18.4 µM 4.81368561547493 2.88581344547415e-07 yes 23 7.4085923392457e-07 8 5403974 SGTC_1740 st038286 13.222 µM 4.57416605203491 1.00765553816693e-06 yes 24 2.39060270342998e-06 16 716786 SGTC_1498 4478-3555 97.6 µM 4.38395667696692 2.60841779171638e-06 yes 25 5.82714799147609e-06 4 3437919 SGTC_340 k038-0059 454 µM 4.19012778535778 6.6189875386952e-06 yes 26 1.39398700772403e-05 43 23733424 SGTC_1748 st037455 53.6035 µM 4.02128246112531 1.44389009496693e-05 yes 27 2.89410737037081e-05 30 580690 SGTC_3318 9139014 38.6185 µM 3.95371896272005 1.95684922844293e-05 yes 28 3.84728911744732e-05 14 16643984 SGTC_2921 7974240 10.71 µM 3.92707585283916 2.2032643728273e-05 yes 29 4.29924349998798e-05 58 2979074 YDR527W RBA50 SGTC_216 k038-0035 28.382 µM 3.86528627660986 2.89282309533649e-05 yes 30 5.54794877712583e-05 50 4444231 YPR107C YTH1 SGTC_1163 k060-0048 49.9 µM 3.8555098158069 3.01910713014818e-05 yes 31 5.77443481445617e-05 24 6809982 SGTC_2582 agaric acid 100 µM 3.80965196069385 3.68434456117654e-05 yes 32 6.9581276173237e-05 334 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_138 0850-0259 40.9225 µM 3.76187416676252 4.52355554929805e-05 yes 33 8.43224468625637e-05 212 6813004 SGTC_1880 MG-132 525 µM 3.75457669534061 4.66663285775788e-05 yes 34 8.68173367101231e-05 22 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_984 1492-0255 2.91 µM 3.65817143066327 7.00599480546901e-05 yes 35 0.000127010561778721 35 1585198 SGTC_1652 st011932 78 µM 3.62490462179219 8.04300460489776e-05 yes 36 0.000144534057386248 20 1551076 SGTC_2054 5233173 129 µM 3.59922492182426 8.94052827885869e-05 yes 37 0.000159583524233468 68 6889 SGTC_200 k038-0079 37.545 µM 3.53256267874351 0.000117296775632582 yes 38 0.000205776326708781 64 3436683 SGTC_359 0081-0058 15.9 µM 3.47576584592868 0.000147307888195822 yes 39 0.000254698417953193 66 3494159 SGTC_1567 st069303 68.4 µM 3.41090383114666 0.000190324456832478 yes 40 0.000323739620360282 36 5581319 SGTC_594 1487-1584 10.8 µM 3.38440068478123 0.000211072871017388 yes 41 0.000356669101354072 41 5013332 SGTC_2408 sulbentine 18.36 µM 3.36830191147798 0.000224687901053654 yes 42 0.000378163622640625 67 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2452 5863136 48.41 µM 3.36726361875987 0.000225593552648807 yes 43 0.00037959039468464 44 2184096 SGTC_2337 9009472 200 µM 3.3571325444666 0.000234610949282084 yes 44 0.000393776744281424 58 5742383 SGTC_1642 st009582 77.7 µM 3.27619812289215 0.000319688850179375 yes 45 0.000526073621607288 37 6739311 SGTC_246 cycloheximide 667 µM 3.26042765709773 0.00033929762251645 yes 46 0.000556221707581345 31 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_736 0958-0254 92.6 µM 3.25438455202108 0.000347103499372437 yes 47 0.000568191690230065 58 6812352 SGTC_1974 st069448 26.9 µM 3.24835177238075 0.000355062241997675 yes 48 0.000580378347295703 51 6323587 YNR016C ACC1 SGTC_2870 9038528 12.99 µM 3.24560028713262 0.000358748154331277 yes 49 0.000586016372951644 41 6463316 SGTC_3004 9076122 71.4286 µM 3.24433991635861 0.000360448401728883 yes 50 0.000588615843629065 36 44782551 SGTC_3328 9140624 29.0385 µM 3.20103997445379 0.000423614042841773 yes 51 0.000684662668568785 37 4904392 SGTC_272 doxorubicin 8.13 µM 3.18417943554331 0.000450876352775684 yes 52 0.000725824984700755 60 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_9 0092-0002 10.449 µM 3.17598371962249 0.000464707567441094 yes 53 0.000746646657365233 62 759368 SGTC_294 k038-0071 157 µM 3.16028157818517 0.000492310946942841 yes 54 0.000788083667346804 103 24152826 SGTC_23 0213-0011 39.996 µM 3.14873205820593 0.000513574923419501 yes 55 0.000819902353647791 50 627608 SGTC_2429 5902844 64.44 µM 3.12547839435272 0.000558989105742635 yes 56 0.000887580548194715 68 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3219 9131112 49.47 µM 3.07481778334419 0.000671067573052345 yes 57 0.00105315598451365 71 17612988 YMR079W SEC14 SGTC_1396 3511-0007 98.6 µM 3.06774845269964 0.000688260277022235 yes 58 0.001078390434144 42 X1396 SGTC_829 1635-0120 117 µM 3.0606292408684 0.000705984050930182 yes 59 0.00110436206546102 80 285054 SGTC_1161 k007-0610 110 µM 3.03359306329898 0.000777195013692406 yes 60 0.00120830081137812 170 5843850 SGTC_2651 TUB2.036 5 µM 3.00934857031861 0.000846618555103401 yes 61 0.0013090427696946 239 15992207 YFL037W TUB2 SGTC_464 bw-b 70c 158 µM 2.96400910942165 0.000991966983397364 yes 62 0.00151829648815862 73 5353454 SGTC_384 k007-0144 5.16 µM 2.94241418869768 0.00106895625902245 no 63 0.0016283201428614 114 6824886 SGTC_29 0299-0004 12.984 µM 2.93726303863658 0.00108811258968477 no 64 0.00165561558301301 63 16871 A napthoquinone isolated from Swertia calycina. SGTC_571 k831-0106 44.2 µM 2.93519936369219 0.00109587498040305 no 65 0.00166666723161819 54 4783639 SGTC_268 camptothecin 39.6153 µM 2.9251545884195 0.00113438762797968 no 66 0.00172142573708464 153 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2785 7756463 72.73 µM 2.90879770892821 0.00119976306238208 no 67 0.00181410772014543 83 2201551 SGTC_2786 7743617 45.45 µM 2.90522209939791 0.00121450581580811 no 68 0.00183496291525151 74 583674 SGTC_1948 st076329 66.6 µM 2.89835342868356 0.0012432924462226 no 69 0.0018756380031816 87 24208413 SGTC_1044 1222-0021 1.78 µM 2.86922783454368 0.00137242477892563 no 70 0.00205737642808933 97 4306703 SGTC_2642 cholecalciferol 100 µM 2.81920423759901 0.00162310965006791 no 71 0.0024071437483648 58 9821465 A vitamin D precursor, similar to steriods. SGTC_1867 st057372 64 µM 2.80573396051708 0.0016974002995491 no 72 0.00251010609250678 52 688837 SGTC_3064 1327-0027 10 µM 2.79473210659755 0.00176035966372991 no 73 0.00259713693124897 32 16000455 YPR107C YTH1 SGTC_586 0957-0265 8.15 µM 2.79405496653088 0.00176430322694363 no 74 0.00260258151944047 86 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1698 5-fluorocytosine 1.055 µM 2.78666237476833 0.0018078824982145 no 75 0.00266269654553347 46 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2325 6158266 200 µM 2.76431080922448 0.00194566570279382 no 76 0.00285215878318775 84 3623240 SGTC_2210 7115885 190.385 µM 2.75116179379056 0.00203111065691377 no 77 0.00296921525200255 90 2927039 SGTC_2451 5856223 45.7 µM 2.74034778541551 0.00210391917546031 no 78 0.00306871014252797 80 2179896 SGTC_787 4152-0075 138 µM 2.73600703699846 0.00213380451038351 no 79 0.00310948480452107 79 9566539 SGTC_503 tyrphostin 8 294 µM 2.70738849305226 0.00234066609506686 no 80 0.00339074239125935 106 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1133 3473-0247 50 µM 2.70643179435896 0.00234788481637565 no 81 0.00340052757072809 132 711311 SGTC_497 capsazepine 133 µM 2.65699658981003 0.00274947388700422 no 82 0.00394201202699263 70 2733484 A calcium channel blocker. SGTC_2767 sibutramine 71.45 µM 2.61993251743026 0.0030901563223434 no 83 0.00439735841883365 100 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2415 st077333 57.7 µM 2.61908805197713 0.00309834303871222 no 84 0.00440825935205788 160 2766255 SGTC_2196 6573537 42.6665 µM 2.60851684375029 0.00320249127989353 no 85 0.00454677681209713 54 2903087 SGTC_2841 9004761 38.96 µM 2.59953591114202 0.00329343538787297 no 86 0.00466749553282484 107 2991039 SGTC_55 0767-0285 6.563 µM 2.59021366915606 0.00339028590596914 no 87 0.00479581886020552 126 3116166 SGTC_2277 7947813 106.88 µM 2.584841013314 0.00344725896975663 no 88 0.00487119547522662 123 1246798 SGTC_2871 9038510 12.99 µM 2.57744370138649 0.00352710931886161 no 89 0.00497670470156302 98 4945164 SGTC_2746 daunorubicin 9.88 µM 2.56010144549658 0.00372085807855818 no 90 0.0052320806316608 28 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3127 9126946 49.47 µM 2.53823708040146 0.00397870432940096 no 91 0.00557062408030961 95 27243249 SGTC_1369 1866-0067 208 µM 2.53758928218425 0.00398658211490637 no 92 0.00558094465203945 143 3531355 SGTC_1245 0418-0076 17.2 µM 2.52795761704047 0.00410537052965688 no 93 0.00573641004068944 118 6790114 SGTC_2718 lomofungin 53.02 µM 2.52484011854361 0.00414449199070866 no 94 0.00578754683188059 77 5351222 A RNA synthesis inhibitor. SGTC_443 clozapine 122 µM 2.51816397948158 0.00422939476697612 no 95 0.00589841925956918 69 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2991 9074669 71.4286 µM 2.50583694102894 0.00439025857833299 no 96 0.00610809711019402 166 17333109 SGTC_1260 0700-1617 7.75 µM 2.50295982618064 0.00442858199634867 no 97 0.00615797615323849 154 2853078 SGTC_953 1188-0045 9.7 µM 2.49449543188066 0.00454306718403486 no 98 0.00630681750371225 130 6144426 SGTC_2935 9038016 29.96 µM 2.48244639591347 0.00471059411199907 no 99 0.00652418491573497 125 6463195 SGTC_519 k048-0011 62.8 µM 2.48095564486335 0.00473169964339598 no 100 0.00655153384283604 116 6836379 SGTC_1000 4048-0884 8.67 µM 2.4792848582215 0.00475545425435818 no 101 0.00658230610399312 127 13040088 SGTC_163 TUB2.036 7.546 µM 2.4602158820036 0.00503419938280939 no 102 0.00694267322624042 280 15992207 YJR013W GPI14 SGTC_969 1313-0238 134 µM 2.44738181997912 0.00522990591533509 no 103 0.00719491537579251 150 5212874 SGTC_1348 1493-0373 93.8 µM 2.40588123622146 0.00590988663957927 no 104 0.00806675431879223 118 3010129 SGTC_1550 gossypolone 36.6 µM 2.40572964221505 0.00591250788435246 no 105 0.00807010216595921 130 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2920 7982904 15.77 µM 2.4008524123213 0.00599739319917559 no 106 0.00817846606646314 125 6456808 SGTC_450 aminopyrene 156 nM 2.3921039283809 0.00615236563484831 no 107 0.00837604901373348 152 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1526 st051518 75 µM 2.37148105767167 0.00653180121556442 no 108 0.00885847740599505 129 673993 SGTC_1199 1638-0010 4.46 µM 2.3478122451866 0.00699266179906855 no 109 0.0094420188399793 156 3111136 SGTC_2111 5486399 200 µM 2.34514983701436 0.0070462570218878 no 110 0.00950971723548938 192 689674 SGTC_1807 st050092 58.9 µM 2.34119706422895 0.00712649639639594 no 111 0.00961100909653082 136 5008496 SGTC_184 1494-0393 24.714 µM 2.33474358143104 0.00725923211426368 no 112 0.00977841004674567 194 3090647 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.3335207340092 0.00728462796667996 no 113 0.00981041570314699 174 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3244 9134489 49.47 µM 2.32412939741921 0.00748229005768883 no 114 0.01005927994462 141 16584271 SGTC_727 3032-0951 202 µM 2.31414191195384 0.00769766932681929 no 115 0.0103299695255882 146 3652836 SGTC_551 k048-0028 34.9 µM 2.31363074918291 0.00770883784298422 no 116 0.0103439927467839 159 6836383 SGTC_823 0417-1665 178 µM 2.29158747544497 0.00820423687964372 no 117 0.0109647294403591 163 3429856 SGTC_157 1348-1695 65.819 µM 2.27647512272316 0.00855983014745106 no 118 0.0114087939548136 234 5380510 SGTC_386 1509-0011 3.07 µM 2.26213364226551 0.0089097171594658 no 119 0.0118445738060337 297 3107280 SGTC_1092 toremifene 6.32 µM 2.24093096239006 0.00944994454586974 no 120 0.0125152736409096 180 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2744 captopril 92.04 µM 2.23542328920814 0.00959487920523088 no 121 0.0126947862828619 94 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3237 9133362 49.47 µM 2.23368086242628 0.0096411340355885 no 122 0.0127520395440567 177 43845137 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.22358939663086 0.00991287560985823 no 123 0.0130880413058495 137 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2771 fluoxetine 41.05 µM 2.22062720220061 0.00999390034981191 no 124 0.0131881109008092 155 3386 A selective serotonin reuptake inhibitor. SGTC_3272 9137413 49.47 µM 2.20659631728141 0.0103855889953342 no 125 0.0136711372428641 155 17614870 SGTC_261 5-fluorouridine 15.376 µM 2.1839427095014 0.011046252984224 no 126 0.0144832290625159 178 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_176 1486-1328 72.834 µM 2.17854350371002 0.0112090057981443 no 127 0.0146827985396875 253 22310231 SGTC_1209 2323-2347 50.3 µM 2.17661305991512 0.0112677006466213 no 128 0.0147547249604126 146 5412760 SGTC_560 2332-1943 155 µM 2.17527344677907 0.01130858822873 no 129 0.0148048155607255 132 21177716 SGTC_1204 4049-0315 18.3 µM 2.16987882840094 0.0114745503190379 no 130 0.0150080132979323 188 588402 SGTC_440 fluspirilene 35.1 µM 2.16370622878299 0.0116670381017166 no 131 0.0152434513338771 198 3396 An atypical antipsychotic. SGTC_2534 helenine 20.12 µM 2.15294122372994 0.0120094482304937 no 132 0.0156616490629553 134 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_525 k781-2675 26.7 µM 2.14776938950399 0.0121770286402696 no 133 0.0158660399391991 219 3651118 YDL195W SEC31 SGTC_3137 9097352 49.47 µM 2.13513303736086 0.0125950274406249 no 134 0.0163750723569949 238 44120435 SGTC_1331 1472-0049 76.2 µM 2.11215135513522 0.013387132463748 no 135 0.0173367346737461 200 24051409 SGTC_373 0844-0104 25.9 µM 2.10839029565324 0.0135207782969067 no 136 0.0174986215825566 233 5375804 SGTC_1210 3013-0140 750 nM 2.09169227066384 0.0141281246795855 no 137 0.0182330261921234 154 905973 SGTC_2085 5307070 144.047 µM 2.0862478881999 0.0143311663700463 no 138 0.0184780872120332 174 2840351 SGTC_1046 2001-0062 216 µM 2.07345046266613 0.0148183501780664 no 139 0.0190651883870839 200 739778 SGTC_3302 9125395 16.351 µM 2.0702945561108 0.0149406585673928 no 140 0.019212384538191 188 17599668 SGTC_1644 st010134 20.9 µM 2.05797396382344 0.0154264908482066 no 141 0.0197963163873384 157 3818134 SGTC_655 k060-0012 42 µM 2.05794320775384 0.0154277204108277 no 142 0.0197977927066769 197 5994525 SGTC_1795 st049545 62.3 µM 2.05673874140729 0.0154759386385069 no 143 0.019855681719265 158 5291882 SGTC_2448 5185112 27.17 µM 2.05332790402258 0.0156131866601103 no 144 0.0200203931697344 171 5718189 SGTC_1194 1488-0194 225 µM 2.05240672016125 0.0156504326448277 no 145 0.0200650759915587 227 1391452 SGTC_2817 7995342 71.43 µM 2.05054030448633 0.0157261306927187 no 146 0.0201558674549591 185 18879975 SGTC_1074 carmofur 3.8 µM 2.04242875491966 0.0160587781439799 no 147 0.0205545099207351 264 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1635 st007035 42.4 µM 2.04067767917755 0.0161313743517967 no 148 0.0206414377034627 468 3716403 SGTC_680 0417-1641 114 µM 2.03925610306814 0.0161905167851983 no 149 0.020712237119021 187 2835990 SGTC_2691 st077356 60.2 µM 2.03753843992824 0.0162622252002391 no 150 0.0207980569528128 226 2839272 SGTC_2684 capsaicin 100 µM 2.03249131518875 0.0164745069493761 no 151 0.0210519710542732 192 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1445 4239-0156 97.7 µM 2.02783065392684 0.0166726363752057 no 152 0.0212887673119524 247 4008346 SGTC_2638 epoxomicin 18 µM 2.02254182763606 0.0168999357934999 no 153 0.0215602034936433 226 9915668 A protesome inhibitor. SGTC_2329 6138490 200 µM 2.01163038895299 0.0173772627780806 no 154 0.0221294567605309 206 720019 SGTC_3117 9124945 49.47 µM 2.00844123446785 0.0175189301863846 no 155 0.0222982124225635 167 17592065 SGTC_2179 6298986 200 µM 2.00792929269028 0.0175417630633357 no 156 0.0223254029423796 180 738374 SGTC_475 α-linolenic acid 10 µM 2.00454506624978 0.0176933413112788 no 157 0.0225058522210569 229 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2246 7293507 91.5585 µM 1.99957750889495 0.0179178599411491 no 158 0.022772952290639 229 887656 SGTC_1340 1486-1359 257 µM 1.99499700642665 0.0181270334855255 no 159 0.023021603180881 217 4309068 SGTC_938 3126-1755 342 µM 1.99140298665725 0.018292612198411 no 160 0.0232183005837297 196 1777771 SGTC_2986 9022445 71.43 µM 1.98774549052764 0.0184624365125366 no 161 0.0234199225248146 224 6459286 SGTC_3227 9130768 49.47 µM 1.94483013151059 0.0205574337309536 no 162 0.0258977131631265 164 17720899 SGTC_2292 7671323 168.05 µM 1.93735871077975 0.0209420188710401 no 163 0.0263507550470724 282 937504 SGTC_151 3013-0144 2.285 µM 1.93630233999115 0.0209968829626705 no 164 0.0264153411899277 244 906558 YHR107C CDC12 SGTC_618 k072-0232 33.2 µM 1.92645722975248 0.0215140768061222 no 165 0.0270236536987653 218 5872756 YGL099W LSG1 SGTC_740 k014-0057 261 µM 1.9174491628047 0.0219966916221452 no 166 0.0275904467867925 271 4012779 SGTC_1779 st039427 55 µM 1.90608048686511 0.022618795333273 no 167 0.0283198819742498 311 1124498 SGTC_876 0720-0963 56.8 µM 1.89660514411885 0.0231485656111098 no 168 0.0289400355819186 236 765861 SGTC_1077 5-fluorocytosine 377 nM 1.89562624513595 0.0232038868736084 no 169 0.0290047421466127 229 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2092 5303694 80.6725 µM 1.88167990042234 0.0240042114284853 no 170 0.0299397451865578 287 1963699 SGTC_459 nigericin 15.3 µM 1.87728794699732 0.0242610011099093 no 171 0.0302393196375862 310 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2369 9071472 200 µM 1.87641781674244 0.0243121489221209 no 172 0.0302989649818724 260 17296037 SGTC_769 0302-0231 76 µM 1.86537326446693 0.024969273737276 no 173 0.0310645510871121 339 571869 YER009W NTF2 SGTC_2382 9035899 200 µM 1.85904766564702 0.0253522940491835 no 174 0.0315101911789631 259 6462679 SGTC_1137 ixabepilone 100 µM 1.84717694510002 0.0260843645949582 no 175 0.032360749803204 305 154225 A novel microtubule stabilizer. SGTC_2360 9040895 200 µM 1.84243524297871 0.0263816877144909 no 176 0.0327057553185851 252 4914414 SGTC_7 0192-1582 4.227 µM 1.84082370661526 0.0264833800337661 no 177 0.0328236987872246 362 252616 SGTC_1017 4239-0030 168 µM 1.83525765597925 0.0268371355330623 no 178 0.03323376096584 309 1149593 SGTC_3029 9088683 49.47 µM 1.83492126721873 0.0268586408611041 no 179 0.0332586780163463 259 25236615 SGTC_3030 9087619 49.47 µM 1.82666052692541 0.0273912815489336 no 180 0.0338754133565318 266 25236973 SGTC_765 1319-0117 244 µM 1.82643671608077 0.0274058342391549 no 181 0.0338922527802942 253 3487746 YGL099W LSG1 SGTC_3170 9103054 49.47 µM 1.81627436154707 0.0280734382905564 no 182 0.03466414804913 239 16432970 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.81565949197158 0.0281142621626585 no 183 0.034711310768488 292 5282309 SGTC_2652 actinonin 100 µM 1.80536665031317 0.028805020052432 no 184 0.0355086631211853 207 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_352 k048-0007 5.11 µM 1.80210118375603 0.0290270936143394 no 185 0.0357647437559164 341 6811911 SGTC_1481 3346-2004 36 µM 1.80011239595311 0.0291630402548299 no 186 0.0359214463322227 287 2770522 SGTC_223 busulfan 5 mM 1.79847418733053 0.0292754194243201 no 187 0.0360509477932103 185 2478 A DNA alkylator. SGTC_1020 4335-0961 93.3 µM 1.79793137689476 0.0293127348137685 no 188 0.036093941554763 267 669075 SGTC_1706 st031321 9.9705 µM 1.79703766048287 0.0293742592124964 no 189 0.0361648205943086 251 6103185 SGTC_513 4245-1575 41.7 µM 1.79637451664814 0.0294199800145837 no 190 0.0362174869602957 457 719745 SGTC_2491 paeonol 100 µM 1.7901212704666 0.0298540257106691 no 191 0.036717209023333 231 11092 Increases levels of cortical cytochrome oxidase. SGTC_2055 5235184 200 µM 1.77450058383604 0.0309615278037042 no 192 0.037990192802567 313 2836034 SGTC_1621 st003705 32.4 µM 1.76607216513472 0.0315730868651118 no 193 0.0386918712960526 338 24207032 SGTC_1275 0867-0008 21.1 µM 1.76234560855982 0.0318466481396827 no 194 0.03900546120407 306 3422836 SGTC_3020 9089140 49.47 µM 1.76201110108147 0.0318712993343903 no 195 0.0390337109492008 304 17217859 SGTC_2283 7944793 200 µM 1.75958525066032 0.0320505419462362 no 196 0.0392390770624898 323 2970533 SGTC_2462 5162487 171.77 µM 1.75174094705305 0.0326358519684783 no 197 0.0399091812738023 288 2259986 SGTC_2569 tetrandrine 100 µM 1.75039196089361 0.0327373907406232 no 198 0.0400253511252342 267 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_553 k007-0256 45.7 µM 1.74495336131965 0.033149401818578 no 199 0.0404964938197601 320 6287000 SGTC_1283 0922-0125 16.4 µM 1.73632346239426 0.0338119357041388 no 200 0.0412533284664122 328 3360884 SGTC_2166 5933061 31.504 µM 1.73243068864114 0.0341143367442701 no 201 0.0415984539406113 321 2877375 SGTC_2106 5357045 167.29 µM 1.73044104407437 0.0342697542832755 no 202 0.0417757530178915 324 668842 SGTC_1295 1013-0063 9.78 µM 1.72960341794417 0.0343353578016832 no 203 0.0418505774841679 309 6826038 SGTC_2878 9043973 25.97 µM 1.72747936929904 0.0345021777094632 no 204 0.0420408036004846 274 6465167 SGTC_1895 st058434 18.3 µM 1.7268882760245 0.0345487196278376 no 205 0.0420938651922146 312 5393175 SGTC_3332 9141069 11.198 µM 1.72037806761977 0.0350647450856093 no 206 0.0426818705381111 269 17332883 SGTC_2295 7971645 200 µM 1.71929789670579 0.035150972500359 no 207 0.0427800713792419 331 2978226 YKL099C UTP11 SGTC_1325 1431-0015 227 µM 1.71630620970617 0.0353907001267591 no 208 0.0430530061873443 289 1103340 SGTC_1446 4239-0190 62 µM 1.71372803978606 0.0355983661847939 no 209 0.0432893423544322 368 1340085 SGTC_2834 9001755 58.44 µM 1.7107455760234 0.0358398422601472 no 210 0.0435640451427596 306 2989575 SGTC_1493 4348-0038 111 µM 1.71042933254623 0.035865525520196 no 211 0.0435932553779986 349 800424 SGTC_846 0335-0850 148 µM 1.7090580476692 0.0359770669615795 no 212 0.0437200987863144 277 6819598 SGTC_538 2922-0838 53.3 µM 1.70360756134668 0.0364232265205553 no 213 0.0442272139526222 380 777039 SGTC_237 nikkomycin 200 µM 1.69981792394503 0.0367360949659768 no 214 0.0445825894939071 333 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3151 9099821 49.47 µM 1.69687914646525 0.036980227558739 no 215 0.0448597556650175 291 17174189 SGTC_2818 7996756 12.99 µM 1.69402295247851 0.0372187690035796 no 216 0.045130460813904 236 2241621 SGTC_3263 9137018 49.47 µM 1.68478761953665 0.0379986964612818 no 217 0.0460147771897126 338 43844957 SGTC_2759 disulfiram 3.38 µM 1.68473509529355 0.0380031699939423 no 218 0.0460198461001353 331 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1081 sertraline 6 µM 1.67575202844566 0.0387746090289348 no 219 0.0468933870478146 388 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3350 9150499 3.57 µM 1.67284929467919 0.039026597073148 no 220 0.0471784839121131 397 4910996 YPR165W RHO1 SGTC_599 1935-0052 86.5 µM 1.6725575702668 0.0390519954070384 no 221 0.0472072127852621 352 9557311 SGTC_2083 5306046 65.942 µM 1.67035244588218 0.0392444152287522 no 222 0.0474248261876112 372 539837 SGTC_2705 st078069 42.8 µM 1.66510942168041 0.0397050224167911 no 223 0.0479454636874527 310 1530061 SGTC_1500 4488-1866 171 µM 1.66473349133977 0.0397382166196011 no 224 0.0479829690382611 362 2900003 SGTC_1430 4049-0248 69.1 µM 1.66313735199892 0.0398794051846195 no 225 0.0481424722712116 378 22774488 SGTC_523 1934-0222 13.7 µM 1.66038236577454 0.0401240601169516 no 226 0.0484187776864585 362 1361595 SGTC_3089 9117425 49.47 µM 1.65561598243106 0.0405502148367528 no 227 0.0488998057338923 344 9401657 SGTC_3133 9127736 49.47 µM 1.65314653850527 0.0407724445630689 no 228 0.0491505219041879 340 27243420 SGTC_2020 4017018 200 µM 1.65144551203917 0.0409260970482128 no 229 0.0493238190538616 348 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2331 7980721 200 µM 1.64562968545051 0.0414549880663275 no 230 0.0499200117812118 361 2981221 SGTC_3066 9117245 49.47 µM 1.64493878386759 0.0415181850478329 no 231 0.0499912179020057 338 17176980 SGTC_468 gf-109203x 121 µM 1.64434630047777 0.0415724418397096 no 232 0.0500523452759476 213 2396 A protein kinase C inhibitor. SGTC_1808 st050063 61.5 µM 1.63832180495817 0.0421274041860095 no 233 0.0506772906946857 341 4011993 SGTC_961 1252-1571 372 µM 1.63453990957633 0.0424788362366384 no 234 0.051072766684978 368 6813498 SGTC_2201 6605497 169.863 µM 1.63053966551109 0.0428531347256834 no 235 0.0514937445068468 306 670741 SGTC_1384 3089-0840 101 µM 1.62937194732961 0.0429628980461076 no 236 0.0516171518290407 315 1069836 SGTC_994 3910-0338 138 µM 1.62564748680669 0.0433145088926229 no 237 0.0520123335746139 398 3479481 SGTC_2483 5729050 27.16 µM 1.62383024749677 0.0434869083959415 no 238 0.0522060213127429 450 2865180 SGTC_2461 5755302 26.15 µM 1.62294259715066 0.0435713199380602 no 239 0.0523008382155914 389 2788904 SGTC_1001 4048-4355 44.4 µM 1.61942103388457 0.0439075085371478 no 240 0.0526783521001689 353 21824233 SGTC_281 1672-3440 14.9 µM 1.61916008903093 0.0439325028572541 no 241 0.0527064113855389 361 6833000 SGTC_1882 5615643 20 µM 1.6159892296415 0.0442371380306689 no 242 0.053048320920923 308 2253075 SGTC_839 0122-0028 230 µM 1.61287115331628 0.0445383603102686 no 243 0.0533862517491025 434 759448 SGTC_1734 st037168 69.4 µM 1.61199436761491 0.0446233593322105 no 244 0.0534815826896656 366 708907 SGTC_1691 st019933 84.6 µM 1.6071010533492 0.0451001384993469 no 245 0.0540161011430493 324 6176082 SGTC_1346 1488-2224 62.4 µM 1.60647837992978 0.0451611014996614 no 246 0.0540844207687294 362 3722427 SGTC_2153 5569715 200 µM 1.5982793502382 0.0459700304810538 no 247 0.0549904104711517 340 2054701 SGTC_931 2812-0076 566 µM 1.59822405433018 0.0459755253225731 no 248 0.054996561111049 381 3450959 SGTC_1249 0481-0015 10.2 µM 1.59687968309749 0.0461092800539573 no 249 0.0551462647043991 327 4227577 SGTC_635 k038-0028 24.7 µM 1.59501804269285 0.0462950150219273 no 250 0.0553541005615223 384 4035102 SGTC_2985 9022375 71.43 µM 1.59429020595275 0.0463677940884503 no 251 0.0554355251565579 377 4939335 SGTC_1816 st051957 91.6 µM 1.59000131761931 0.0467985230418489 no 252 0.055917254018386 346 674121 SGTC_1453 4237-0541 195 µM 1.58875392856286 0.0469243978546153 no 253 0.056057979188799 362 739892 SGTC_662 k832-1615 104 µM 1.58769764608454 0.0470312001689407 no 254 0.0561773627948429 363 5878478 SGTC_2628 lathosterol 100 µM 1.58240468173651 0.0475693184967294 no 255 0.0567786083160542 388 6710616 SGTC_2514 salinomycin 42.74 µM 1.57910142325009 0.0479076418632899 no 256 0.0571563976498006 442 23682228 A polyether potassium ionophore. SGTC_1919 st067113 52.3 µM 1.57599142041157 0.0482279296431912 no 257 0.0575138902374582 412 1268243 SGTC_695 3505-6186 243 µM 1.57366712651228 0.0484684169210603 no 258 0.057782212774241 373 1819379 SGTC_2845 9003024 42.97 µM 1.5631453982911 0.0495690865952525 no 259 0.0590091997762394 416 2990173 SGTC_824 1304-0008 100 µM 1.55986482948269 0.0499163144924492 no 260 0.0593959136614707 432 768245 SGTC_1467 k284-1082 293 µM 1.55797911549505 0.0501167819744158 no 261 0.0596190994645032 391 3334705 SGTC_1877 wortmannin 25 µM 1.55417937974891 0.0505226757771088 no 262 0.0600708173384361 466 312145 A covalent inhibitor of PI 3-kinase. SGTC_1180 1193-0155 285 µM 1.5530626081888 0.0506424677598507 no 263 0.060204089012902 392 2921347 SGTC_1440 4100-1550 40 µM 1.54682526286454 0.0513156906054012 no 264 0.060952693343504 319 742806 SGTC_3158 9100007 49.47 µM 1.54116869947311 0.0519323651623415 no 265 0.061637866633963 337 19297233 SGTC_885 0865-0106 16.8 µM 1.5397842364944 0.0520841918051338 no 266 0.0618064778056187 412 2793380 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.53953441639335 0.0521116257540136 no 267 0.0618369412406393 343 17037758 SGTC_810 3825-7150 143 µM 1.5381662557307 0.0522620736891001 no 268 0.0620039846858996 400 22330411 YGL099W LSG1 SGTC_759 3486-0358 89.3 µM 1.53603013924605 0.0524976582925427 no 269 0.0622654942937452 442 875103 SGTC_150 3970-0969 77.2 µM 1.5350334610592 0.0526078663756575 no 270 0.0623878045015779 495 6615640 SGTC_1101 ebselen 5.29 µM 1.53388042130706 0.0527355931921901 no 271 0.0625295367192858 410 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2139 5578692 56.4705 µM 1.52860760395513 0.0533228223877163 no 272 0.0631808749168505 350 650991 YMR113W FOL3 SGTC_1681 tripelennamine 100 µM 1.52819096974328 0.0533694426489114 no 273 0.0632325651026382 354 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2022 5136654 200 µM 1.52540773241453 0.0536817087111913 no 274 0.0635787156550937 410 1713771 SGTC_2646 retinol 96.75 µM 1.51758243402644 0.0545674283578774 no 275 0.0645598489481805 396 445354 A vitamin A analog and teratogen. SGTC_116 0155-0182 31.788 µM 1.51676188049825 0.0546609696720633 no 276 0.0646634072723809 563 771486 SGTC_2827 7993847 71.43 µM 1.5099951468657 0.0554372042279566 no 277 0.065522331268379 357 2985692 SGTC_2379 9035213 200 µM 1.50926892766358 0.0555210258347123 no 278 0.0656150359478921 444 646551 SGTC_236 1509-0011 5.31 µM 1.50505240412992 0.0560096835795367 no 279 0.0661553021757665 731 3107280 SGTC_2650 prasterone 100 µM 1.50084579483319 0.0565005663361883 no 280 0.0666977254289521 306 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_37 0566-0070 1.56 µM 1.50055713485 0.0565343749124146 no 281 0.0667350726495806 466 1626686 SGTC_2065 5221596 34.26 µM 1.49951419988877 0.0566566589146501 no 282 0.0668701438591168 413 788581 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.49877951145962 0.0567429260750996 no 283 0.0669654207554961 497 688788 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.49251567501342 0.0574826338954568 no 284 0.0677820055470686 505 91467 include heat shock SGTC_1651 st011928 86.1 µM 1.49172645871343 0.0575763695260144 no 285 0.067885434950476 412 720198 SGTC_2339 9000433 200 µM 1.48492831122145 0.0583887747809487 no 286 0.0687814077282953 387 2988954 SGTC_626 0214-0009 33 µM 1.48489666629668 0.0583925774156815 no 287 0.0687855996392215 433 3437874 SGTC_426 0988-0037 14.6 µM 1.48126957437838 0.0588297196721725 no 288 0.0692673763905166 502 5383008 SGTC_718 1130-0073 349 µM 1.47845983482627 0.0591701154340262 no 289 0.0696423700651646 444 6740020 SGTC_1737 st035557 69.7 µM 1.47108608844272 0.0600707814261287 no 290 0.0706339183735855 362 5716916 SGTC_1836 st055642 81 µM 1.46926917536384 0.0602943483551064 no 291 0.0708798970181406 462 8571 SGTC_728 3030-5151 22.5 µM 1.45938919504267 0.0615214755653979 no 292 0.0722290091006566 404 3125388 SGTC_927 2425-1185 123 µM 1.45688823654483 0.0618351760714616 no 293 0.0725736168595727 422 730375 SGTC_2666 tannic acid 100 µM 1.45631954377448 0.0619066823425312 no 294 0.0726521526442859 485 16134267 A thiamine antagonist. SGTC_2124 5246320 200 µM 1.45611536015881 0.0619323717140425 no 295 0.0726803660290083 431 579342 SGTC_458 nppb 133 µM 1.45174851556401 0.0624837804533532 no 296 0.0732857720115406 392 4549 A chloride channel blocker. SGTC_2199 6590217 200 µM 1.45126140358818 0.062545525448111 no 297 0.0733535421851169 374 703109 SGTC_3011 9081274 71.4286 µM 1.45014895874224 0.0626867142927186 no 298 0.0735084924507489 475 6625322 SGTC_912 3474-0017 2.18 µM 1.44940638751459 0.0627810978216412 no 299 0.0736120629607639 456 3360550 SGTC_546 peri-Naphthalide 147 µM 1.44841816586786 0.0629068761214843 no 300 0.0737500686802901 458 223824 A penicillin ester. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.44792979095856 0.0629691076591821 no 301 0.0738183434919953 394 279621 SGTC_1666 st014829 29 µM 1.44575427086601 0.0632469077354638 no 302 0.0741230682051301 481 3858230 SGTC_1474 0330-0125 5.35 µM 1.44508503561906 0.0633325564655179 no 303 0.0742170008647141 435 X1474 SGTC_2044 5102272 200 µM 1.44507397800967 0.0633339723763095 no 304 0.0742185536540725 397 592666 SGTC_2944 9067346 25.62 µM 1.44273311149549 0.063634272117759 no 305 0.0745478339779455 469 6473075 SGTC_3307 9126885 69.2785 µM 1.44231167464743 0.0636884539378582 no 306 0.074607234082532 495 24824909 SGTC_1451 4152-0210 104 µM 1.43737239942506 0.0643261478781396 no 307 0.0753061034886254 465 659563 SGTC_562 3772-2733 112 µM 1.43634229875617 0.0644597640706854 no 308 0.075452481706622 528 2876874 YIL048W NEO1 SGTC_1996 st072960 66.8 µM 1.42776849071109 0.0655802692683184 no 309 0.0766792524908431 474 1719405 SGTC_168 3970-0862 530.542 µM 1.42156495399339 0.0664003794837534 no 310 0.0775762923792163 665 3135186 SGTC_1370 2001-0092 44.6 µM 1.42034727119416 0.0665622860456385 no 311 0.0777533027600419 550 790957 SGTC_1939 st074455 53.6 µM 1.41873202356597 0.0667775252786713 no 312 0.0779885786266106 494 1644229 SGTC_1558 st069300 45.6 µM 1.41593704913863 0.0671512402686155 no 313 0.078396968151704 372 24208000 SGTC_2974 9094440 9.66 µM 1.41350684917072 0.0674774940095726 no 314 0.0787533744761449 520 25236134 SGTC_672 1441-0018 53.7 µM 1.41054756574886 0.0678764295536675 no 315 0.0791890308690292 450 251141 SGTC_2043 5101342 149 µM 1.40864726619487 0.0681335642160541 no 316 0.0794697475731681 484 678451 SGTC_1647 st011722 22.4 µM 1.40770751673952 0.0682610018051006 no 317 0.0796088475625956 438 2854783 SGTC_1091 telmisartan 47.6 µM 1.40503055702454 0.0686250274959426 no 318 0.0800060959792575 481 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2264 7948757 110.76 µM 1.4048993914995 0.0686429024105058 no 319 0.0800255987833248 448 2971411 SGTC_1999 st074831 12.5 µM 1.40244367090218 0.0689782252969311 no 320 0.080391400104006 495 17112523 SGTC_1280 0880-0253 10.1 µM 1.39835663089864 0.0695390984075142 no 321 0.0810029998849723 497 6836607 SGTC_79 0052-0007 94.094 µM 1.39763671484796 0.06963825675498 no 322 0.0811110936178423 478 2801472 SGTC_2913 7966556 36.57 µM 1.39345976572548 0.0702157223257851 no 323 0.0817404018010812 437 2976516 SGTC_3229 9132204 49.47 µM 1.39304295517887 0.0702735481177601 no 324 0.0818034007845469 412 17682924 SGTC_945 3381-0768 11.3 µM 1.39249391787211 0.0703497741403308 no 325 0.0818864410746481 515 1126236 YIL048W NEO1 SGTC_1654 st012436 41.8 µM 1.38980000918623 0.0707247066334093 no 326 0.0822948076636999 424 4323132 SGTC_1552 6-methylflavone 10.6 µM 1.38901850622028 0.0708337613864978 no 327 0.0824135613390592 426 689013 SGTC_305 1682-2595 20.8 µM 1.38020709344847 0.0720723053511113 no 328 0.083761445288932 502 226033 SGTC_1718 roemerine 11.9335 µM 1.37782317800908 0.0724102286652888 no 329 0.0841289440199099 570 235224 An aporphine alkaloid with mutagenic activity. SGTC_3143 9086658 49.47 µM 1.37624173295742 0.072635069564329 no 330 0.0843734027902324 569 25236626 SGTC_2045 5106652 78.05 µM 1.37516529614435 0.072788416823341 no 331 0.0845401023332423 477 673349 SGTC_507 nimesulide 162 µM 1.37189059348981 0.0732564492954129 no 332 0.0850487495608733 516 4495 A COX2 inhibitor. SGTC_3201 9113999 49.47 µM 1.37184654439541 0.0732627606090042 no 333 0.0850556071406366 492 16649224 SGTC_1819 st053448 58.6 µM 1.37074642654094 0.0734205194388992 no 334 0.0852270083529493 488 2857616 SGTC_1255 0566-0045 221 µM 1.37049413069878 0.0734567357027141 no 335 0.0852663531549987 523 2788469 SGTC_1731 st035964 63 µM 1.36607662750672 0.0740930701609121 no 336 0.085957456701967 502 6739575 SGTC_2910 7948405 25.97 µM 1.36415750048297 0.0743708259788322 no 337 0.086259000413723 455 2971328 SGTC_283 0987-0079 11.7 µM 1.36333346612796 0.0744903324004662 no 338 0.0863887197080585 550 411556 SGTC_3069 9117009 49.47 µM 1.35902751670319 0.0751171927693276 no 339 0.0870689346865798 382 41904981 SGTC_3180 9109287 49.47 µM 1.35613041102267 0.0755412119776305 no 340 0.0875288392128956 451 18891271 SGTC_1252 0493-0875 34.8 µM 1.35013324443044 0.0764247469126362 no 341 0.0884866231742812 491 3960963 SGTC_2602 kawain 100 µM 1.34760563463189 0.0767994745340131 no 342 0.0888926286692821 565 5369129 SGTC_3205 9113483 49.47 µM 1.34684712091768 0.0769121991079133 no 343 0.0890147375252792 551 17018033 SGTC_2291 7917025 104.35 µM 1.34468131445107 0.0772347571607287 no 344 0.08936408569067 548 2964612 SGTC_1709 st033179 39.1045 µM 1.34408775718052 0.0773233360538391 no 345 0.0894600052862285 534 573381 SGTC_2320 7373003 200 µM 1.3415291390739 0.0777060522101122 no 346 0.089874357765714 501 5415828 SGTC_2 0422-0095 29 µM 1.3408624767952 0.0778060068053712 no 347 0.0899825535034176 412 6790840 SGTC_585 0kpi-0023 191 µM 1.3385775771538 0.078149328844657 no 348 0.0903541149107388 475 64601 SGTC_1063 disulfiram 1.84 µM 1.33554604583116 0.0786066096236196 no 349 0.090848847692713 515 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1306 1185-0270 9.02 µM 1.33448999351705 0.0787663815387123 no 350 0.0910216620518245 581 1548076 SGTC_614 0462-0418 107 µM 1.3319301339934 0.0791546879565816 no 351 0.091441573900194 477 5188303 SGTC_2484 5809818 12.04 µM 1.33182799188353 0.0791702119652102 no 352 0.0914583587322637 517 2870548 SGTC_1786 berberine 21.6 µM 1.32884291190695 0.0796249164166972 no 353 0.0919499007199649 537 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3329 9141233 27.5565 µM 1.32626222276642 0.080019611851076 no 354 0.0923764276555219 495 4909101 YNL103W MET4 SGTC_1640 st009078 66.4 µM 1.32248986247129 0.080599222770872 no 355 0.0930025414408271 463 690618 SGTC_792 4534-1957 155 µM 1.32228089806604 0.0806314219244074 no 356 0.0930373155753246 519 1717904 SGTC_3292 9120825 59.784 µM 1.32124089993267 0.0807918188955846 no 357 0.093210526446488 525 24824900 SGTC_3015 9080845 49.47 µM 1.31979105997479 0.0810158268831401 no 358 0.0934523936333134 550 5296973 SGTC_1015 4130-4525 82 µM 1.31764723078901 0.0813479185220106 no 359 0.0938108834894425 537 1363237 SGTC_2064 5220758 200 µM 1.31695797291837 0.0814549064313486 no 360 0.0939263561593643 583 788518 SGTC_535 2293-4129 48.2 µM 1.31338753843298 0.0820108152711125 no 361 0.0945261972299058 626 396118 YIL048W NEO1 SGTC_2269 7935389 174.42 µM 1.31197253938646 0.0822319167316365 no 362 0.0947647000706399 533 97605 SGTC_1060 3448-7350 82 µM 1.31161884157711 0.0822872540521616 no 363 0.0948243862448864 579 570178 SGTC_244 nsc-207895 1.295 µM 1.30913081852569 0.0826773071254213 no 364 0.0952450207395904 426 42640 SGTC_1937 st074714 47.2 µM 1.30890810940544 0.0827122894807855 no 365 0.095282739666792 533 17250970 SGTC_941 3237-0776 460 µM 1.30752898569656 0.0829291654196429 no 366 0.0955165586457989 516 760008 SGTC_2589 lobaric acid 100 µM 1.30677304462277 0.0830482232999479 no 367 0.0956449012166731 527 73157 A novel microtubule depolymerizer. SGTC_1496 4469-0713 57.4 µM 1.30304710685602 0.0836369234469177 no 368 0.0962793398519901 548 746691 SGTC_1380 2291-0730 164 µM 1.30300470141809 0.0836436415270859 no 369 0.0962865782493339 495 2999191 SGTC_2126 5251174 33.877 µM 1.30079093238208 0.0839949211361097 no 370 0.0966650132895639 645 790722 SGTC_962 1254-0300 21.5 µM 1.29915329209187 0.0842554929444174 no 371 0.0969456635964428 537 7340576 SGTC_2586 curcumin 80 µM 1.29648895940075 0.0846807218276887 no 372 0.0974035406654971 637 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1140 3229-1848 2.98 µM 1.29626550482124 0.0847164583172187 no 373 0.0974420142802004 540 2849525 SGTC_772 k072-0172 35.3 µM 1.29554104336443 0.0848323972625159 no 374 0.0975668261290823 500 5861980 SGTC_2248 tofa 1.1 µM 1.29461810844251 0.0849802711080528 no 375 0.0977260011984595 512 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_93 0109-0045 59.227 µM 1.2936065106252 0.0851425724946138 no 376 0.0979006862274359 659 88733 SGTC_1848 st056003 16.4 µM 1.29217478330588 0.0853726765932622 no 377 0.0981483111820076 580 146492 SGTC_739 1486-1183 203 µM 1.28839334333855 0.0859826609509212 no 378 0.0988045373781377 568 4346692 SGTC_570 0987-0065 62.6 µM 1.28825010935964 0.0860058299729638 no 379 0.0988294569756195 442 3104428 SGTC_2532 xanthone 78.9 µM 1.287550318584 0.0861190928222455 no 380 0.0989512714758972 502 7020 An insecticide. SGTC_3154 9100113 49.47 µM 1.28410668218168 0.0866780798401307 no 381 0.0995523151549332 552 25237525 SGTC_871 0574-0004 149 µM 1.27832715362817 0.0876223274370909 no 382 0.100567048717912 605 9551173 SGTC_1609 st001574 46.4 µM 1.27709818219391 0.0878241001617613 no 383 0.100783793283254 565 3960012 SGTC_1221 2958-7315 257 µM 1.27646526144484 0.0879281482934765 no 384 0.100895549617045 561 4562705 SGTC_2387 9077560 195.08 µM 1.27415303171143 0.0883090455204614 no 385 0.101304593517837 561 5303272 SGTC_1399 3562-5772 25 µM 1.27393295289632 0.0883453634408832 no 386 0.10134358933654 477 23847490 SGTC_117 lucigenin 22.078 µM 1.27385420308257 0.0883583616228027 no 387 0.101357545691477 627 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1825 st052143 62.6 µM 1.27336580672461 0.0884390065267619 no 388 0.101444132505053 511 674173 SGTC_3184 9108758 49.47 µM 1.2731804324762 0.0884696302172623 no 389 0.101477011236731 538 902885 SGTC_697 0508-1955 564 µM 1.27210102414333 0.0886481046399999 no 390 0.101668613679593 616 6243113 SGTC_3061 glucosamine 200 µM 1.27147217757026 0.0887522046232382 no 391 0.101780359653245 539 91431 and experimental redox chemotherapeutic SGTC_419 nsc-638432 893 µM 1.27019728655347 0.0889635308595557 no 392 0.102007181984027 572 368090 SGTC_1679 SEC14.276 6.7 µM 1.26977887169345 0.0890329689823251 no 393 0.102081704405474 638 1005053 YMR079W SEC14 SGTC_1624 st003710 6.25 µM 1.2664079031435 0.0895938710721878 no 394 0.102683541451312 627 24207033 SGTC_2167 5876490 200 µM 1.26327876761542 0.0901168817972793 no 395 0.103244506968116 572 686534 SGTC_1608 st001473 40.5 µM 1.26315369238241 0.0901378341963224 no 396 0.103266975579052 551 7292267 SGTC_840 0245-0196 390 µM 1.25823645448938 0.0909644324095232 no 397 0.104153127384972 636 3827528 SGTC_3156 9099931 49.47 µM 1.25753738105397 0.0910824032340928 no 398 0.104279555959976 601 18111053 SGTC_2489 cantharidin 73.42 µM 1.25585781104063 0.091366299666294 no 399 0.10458376351223 582 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2161 5662504 8.5105 µM 1.25441422100243 0.091610832336804 no 400 0.104845743123061 559 2859334 SGTC_1104 tacrolimus 29.8 µM 1.25141903928159 0.0921197386327127 no 401 0.105390817263105 619 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1438 4092-1045 4 µM 1.24754501410736 0.0927810680263199 no 402 0.10609886285887 581 1351342 SGTC_3233 9132340 49.47 µM 1.23984405375664 0.0941061025893195 no 403 0.107516540137343 568 17682950 SGTC_3271 9137798 49.47 µM 1.2398102225296 0.094111954264147 no 404 0.107522798133639 505 6498326 SGTC_2342 7990637 118.86 µM 1.23933247687553 0.0941946170052161 no 405 0.107611198082648 608 2033102 YER133W GLC7 SGTC_674 0498-0004 451 µM 1.23872035294283 0.0943006090324696 no 406 0.1077245393138 573 4231473 SGTC_1318 1280-3875 124 µM 1.23784240492257 0.0944527832220195 no 407 0.10788725078007 627 373245 SGTC_611 3453-1652 23.7 µM 1.23648478931527 0.0946884542564801 no 408 0.108139208131951 629 1560575 SGTC_790 1575-0012 79.1 µM 1.23420004855674 0.095086044623166 no 409 0.108564184676668 605 378741 YLR208W SEC13 SGTC_2689 tacrolimus 100 µM 1.23409450471038 0.0951044410207952 no 410 0.108583845503861 569 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3079 9117512 49.47 µM 1.23082795700968 0.0956751002725678 no 411 0.109193608476317 602 7185044 SGTC_2061 5245884 80.95 µM 1.23002650096183 0.0958154971320009 no 412 0.109343590587892 617 573863 SGTC_1637 st007924 17.4 µM 1.22837939889131 0.096104507584214 no 413 0.109652288843385 594 683336 SGTC_2610 ononetin 44.17 µM 1.22767871554225 0.0962276478368536 no 414 0.109783799760271 614 259632 SGTC_328 k915-0120 63.5 µM 1.22629465387501 0.0964712278416223 no 415 0.110043906227712 594 6624543 SGTC_2516 gossypol 71.55 µM 1.22341425739186 0.0969795985823398 no 416 0.110586635518746 637 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3009 9080819 71.4286 µM 1.21705376022342 0.0981091445583525 no 417 0.111791881064199 607 17027216 SGTC_396 dithiazanine 1.25 µM 1.21698862792592 0.0981207608989424 no 418 0.111804271337095 575 10578 An antihelmenthic. SGTC_322 k048-0136 19.3 µM 1.21476581589095 0.0985178034880774 no 419 0.112227711076286 582 6823282 SGTC_944 3370-0224 231 µM 1.20340600186261 0.100565289221666 no 420 0.114409623225861 615 4580514 SGTC_1506 4226-2149 212 µM 1.19673343808081 0.101782327929754 no 421 0.11570523471763 680 991114 SGTC_417 st075190 100 µM 1.19421965603257 0.102243597342794 no 422 0.11619602807708 656 222757 SGTC_409 arachidonic acid 100 µM 1.19316284973627 0.102437970584415 no 423 0.116402800502431 625 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2557 derrustone 83.84 µM 1.19316096425343 0.10243831761205 no 424 0.116403169645028 646 629853 An antioxidant. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.1888427199022 0.103235345296654 no 425 0.117250781909967 605 688803 SGTC_639 0833-0042 114 µM 1.18786954800939 0.103415585810292 no 426 0.117442404366085 666 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_700 3453-2283 142 µM 1.1861946076738 0.103726335085949 no 427 0.117772727629398 689 565664 SGTC_532 1548-0774 215 µM 1.18432783038572 0.104073473215601 no 428 0.118141658135029 668 5932993 SGTC_2233 sulbentine 40.3845 µM 1.18060662118996 0.104767965275869 no 429 0.118879516046074 698 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2428 5615643 7.78 µM 1.17867566931514 0.105129660034923 no 430 0.119263673794546 606 2253075 SGTC_1757 st041620 31.8375 µM 1.17837654952444 0.105185770165973 no 431 0.119323261168422 646 5289815 SGTC_1703 st026983 48.3 µM 1.17434156591873 0.105944787886322 no 432 0.12012912028065 686 1104023 SGTC_1981 st071826 47 µM 1.16922422976913 0.106913088744536 no 433 0.121156650743411 606 11838600 SGTC_3235 9132602 49.47 µM 1.16921373614238 0.106915080883468 no 434 0.121158764132893 676 4912240 SGTC_3026 9090633 49.47 µM 1.16877212273729 0.106998942264609 no 435 0.121247727447158 644 25236842 SGTC_539 4859-0462 2.54 µM 1.1677085480088 0.107201107403846 no 436 0.12146217380822 649 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1018 4259-0013 28.1 µM 1.1674270033639 0.107254669711816 no 437 0.12151898567602 624 6801262 SGTC_2551 apiole 73.87 µM 1.16592515507391 0.107540714026011 no 438 0.121822353735386 488 10659 A possible DNA adduct former. SGTC_1317 1273-0028 910 nM 1.16495783171716 0.107725242743198 no 439 0.122018031133406 642 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_629 3448-6466 76.7 µM 1.16372459797428 0.10796082773699 no 440 0.122267818822825 669 573744 SGTC_916 4466-0038 42 nM 1.15715124023901 0.109222798131085 no 441 0.123605287501288 799 5722064 YGL116W CDC20 SGTC_368 fentichlor 4.58 µM 1.15526255075623 0.109587346093775 no 442 0.123991463336141 568 7329 A pesticide. SGTC_2737 bleomycin 30.5 nM 1.15438201197845 0.109757602763408 no 443 0.124171793280002 713 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3001 9076041 71.4286 µM 1.15028847805221 0.110551601639955 no 444 0.125012537397515 633 16004211 SGTC_1034 k072-0165 12.7 µM 1.14951863313973 0.110701382777158 no 445 0.125171093971512 710 5835461 SGTC_1086 cerivastatin 2.18 µM 1.1487797304489 0.110845280513582 no 446 0.125323409739739 636 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_975 1335-0046 28.5 µM 1.14812112041737 0.110973654556438 no 447 0.125459283182445 653 16486740 SGTC_3188 9110789 49.47 µM 1.14756886939808 0.111081379516643 no 448 0.125573293630369 668 849217 SGTC_1987 st072290 61.9 µM 1.14729625161749 0.111134585361016 no 449 0.125629601340352 681 54697379 SGTC_2402 5553605 200 µM 1.14412236209194 0.11175536544094 no 450 0.126286447466668 687 6758546 SGTC_186 3455-3465 67.277 µM 1.13912281407335 0.112738249470511 no 451 0.127325966593247 575 755278 SGTC_2180 6301957 200 µM 1.13393662888676 0.113764331590023 no 452 0.128410565540961 678 845462 SGTC_602 3130-1533 38.1 µM 1.13375091222623 0.11380119851072 no 453 0.128449523488688 732 720941 SGTC_2399 5884133 200 µM 1.13226642728737 0.114096192132757 no 454 0.128761220101074 646 722445 SGTC_582 0987-0078 156 µM 1.13202084569378 0.114145046034786 no 455 0.12881283529626 802 1625765 SGTC_1783 st039459 87.517 µM 1.13166416361145 0.114216027849618 no 456 0.128887826633243 740 729761 SGTC_3192 9110362 49.47 µM 1.1313818897365 0.114272224275782 no 457 0.128947195328713 707 16649480 SGTC_1638 st008370 60.6 µM 1.13008857897525 0.114529954503051 no 458 0.129219450863732 684 24207134 SGTC_3347 9188721 44.724 µM 1.12903156874453 0.114740901944309 no 459 0.129442258362461 644 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1962 st076595 64.5 µM 1.12888888247536 0.114769398994544 no 460 0.129472355623424 680 279619 SGTC_1436 4092-1007 8.32 µM 1.12746029897006 0.115054990787505 no 461 0.129773958511822 666 2881121 SGTC_1903 st060211 78.3 µM 1.12672995796529 0.11520119019305 no 462 0.129928336075397 723 688960 SGTC_1261 0712-0010 12.7 µM 1.12388471336118 0.115772009614897 no 463 0.130530968586415 717 2840123 SGTC_3287 9117173 37.0625 µM 1.121378364045 0.116276500730976 no 464 0.131063420860138 632 2789709 SGTC_3033 9090887 49.47 µM 1.12113288968597 0.116325994836435 no 465 0.131115650329092 702 19325384 SGTC_473 2-arachidonoylglycerol 10 µM 1.12069987139935 0.116413339180499 no 466 0.131207818482411 665 5282280 An endocannabinoid. SGTC_702 1488-0190 94 µM 1.11872164371486 0.116812960267638 no 467 0.131629454334542 693 949357 SGTC_2013 4024628 200 µM 1.11800149044202 0.116958679345028 no 468 0.131783178404711 625 5230760 SGTC_3167 9103034 49.47 µM 1.11426353156582 0.117717104588208 no 469 0.13258307359361 640 5127859 SGTC_2121 5257820 149.641 µM 1.11410624375305 0.11774909414338 no 470 0.13261680518454 753 791256 SGTC_3314 9135860 59.4275 µM 1.11344330557379 0.117883991635456 no 471 0.132759042384854 725 25252478 SGTC_2069 5228469 200 µM 1.11330238486946 0.117912680868618 no 472 0.132789291268281 652 2835210 SGTC_1780 st038448 24.544 µM 1.11299337211681 0.117975608283354 no 473 0.132855638027432 688 728868 YDL195W SEC31 SGTC_185 k048-0037 25.491 µM 1.11134850396081 0.11831096933731 no 474 0.133209184488203 723 6827589 SGTC_2190 6049624 200 µM 1.11133350790754 0.1183140298784 no 475 0.13321241070152 628 2265554 SGTC_161 4065-0411 162.148 µM 1.10941756895504 0.118705513930926 no 476 0.133625043331087 741 1906281 YLR208W SEC13 SGTC_3238 9133470 49.47 µM 1.10737144522837 0.11912460823611 no 477 0.134066683181623 690 3534688 SGTC_1183 1254-0324 198 µM 1.10519716061117 0.119571096481325 no 478 0.134537083469814 711 5799357 SGTC_2187 6125751 200 µM 1.10484216658578 0.119644106277778 no 479 0.134613992876983 711 874498 SGTC_3356 9151811 4.48 µM 1.10278297699486 0.120068229383826 no 480 0.135060711175136 689 1859254 YPR165W RHO1 SGTC_1231 0242-0792 125 µM 1.10033385185662 0.120574044136938 no 481 0.135593343946968 694 3707635 SGTC_2211 7117706 200 µM 1.09885819693586 0.120879532680002 no 482 0.135914961450309 678 822771 SGTC_3091 9116372 49.47 µM 1.09428459089804 0.121829814646962 no 483 0.136915090652051 657 17169793 SGTC_377 3970-0964 33.1 µM 1.08918802066444 0.122894924331098 no 484 0.138035490248339 803 16481235 SGTC_2096 5468907 200 µM 1.08419456600453 0.123944800312821 no 485 0.139139270254341 707 759785 SGTC_978 1416-0512 87.4 µM 1.0838294927718 0.124021802606843 no 486 0.139220202991068 752 6814003 SGTC_1079 idarubicin 2.36 µM 1.08320686562088 0.124153206131195 no 487 0.13935830650615 701 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_735 3076-0345 636 µM 1.08288193496604 0.124221820401017 no 488 0.139430415636508 777 2888990 SGTC_3166 9102297 49.47 µM 1.0800466195235 0.124821667967785 no 489 0.140060710350064 730 25237072 SGTC_2766 oltipraz 83.91 µM 1.07936523717551 0.124966124341558 no 490 0.140212470698793 697 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2014 4013930 200 µM 1.07878426910924 0.125089384604323 no 491 0.140341954540596 800 64556 SGTC_1243 0416-0003 5.65 µM 1.07824283358713 0.125204333919097 no 492 0.140462700606943 682 2141977 SGTC_316 k060-0003 58.6 µM 1.07816202189391 0.125221496946611 no 493 0.140480728549209 713 6152314 SGTC_1113 artemisinin 1.17947 µM 1.07813314613226 0.125227630065019 no 494 0.140487170702889 769 2240 An anti-malaria and mitochondrial poison. SGTC_2307 7538926 6.34 µM 1.07774174489444 0.125310783112142 no 495 0.140574511713335 728 96582 SGTC_2832 7992762 51.95 µM 1.07717575095227 0.125431096476187 no 496 0.140700878182063 625 2985177 SGTC_1520 flindersine 88 µM 1.07633532078548 0.125609895470876 no 497 0.140888658750797 746 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1998 st075797 76.8 µM 1.07327448859422 0.126262581269906 no 498 0.141573989009597 823 24208315 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.07224510365927 0.126482615454598 no 499 0.141804978320358 702 641818 YHR062C RPP1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.0718571124489 0.126565619041364 no 500 0.141892107981252 721 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1562 morin hydrate 59.1 µM 1.07177480931109 0.12658323116135 no 501 0.141910595132676 705 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1096 rimcazole 32.2 µM 1.06973715723652 0.127019814470941 no 502 0.142368818049857 703 18528119 A dopamine reuptake inhibitor. SGTC_1694 st024011 44.9 µM 1.06637339482982 0.127742818362962 no 503 0.143127441762509 776 2787533 SGTC_1468 k284-1086 134 µM 1.06549082963905 0.127932988866407 no 504 0.143326936626964 786 15996457 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.06138872374635 0.128819470502575 no 505 0.144256639675438 802 1273210 SGTC_212 3807-4682 38.772 µM 1.06054484181194 0.129002363991262 no 506 0.144448400484665 887 3125501 YBL034C STU1 SGTC_2595 hexamethylquercetagetin 100 µM 1.05763176633823 0.129635094542734 no 507 0.14511167712449 693 386331 SGTC_1764 st044502 93.5 µM 1.05644833233114 0.129892753708719 no 508 0.145381717181499 743 8407 SGTC_1916 st067606 49.2 µM 1.05601627027817 0.129986911250414 no 509 0.145480390773226 782 19590279 SGTC_668 1682-0499 62.6 µM 1.0559015026318 0.130011930040738 no 510 0.14550660878115 789 682214 SGTC_1692 fluoroquinolonic acid 71 µM 1.05287614734813 0.13067264504188 no 511 0.146198879730986 725 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1061 3448-9325 110 µM 1.05228120716606 0.130802848187506 no 512 0.146335275591749 728 723482 SGTC_3309 9129340 25.759 µM 1.05202729141408 0.13085844515058 no 513 0.146393514270178 800 17158987 SGTC_1954 st077032 68.9 µM 1.04934879089721 0.131445919958001 no 514 0.147008808900169 657 698907 SGTC_2469 5655019 90.81 µM 1.04779156690613 0.13178830124087 no 515 0.147367324362227 803 2788239 SGTC_788 1182-0090 188 µM 1.04016494791915 0.133474021598139 no 516 0.149131636709964 879 5715185 SGTC_2416 tofa 880 nM 1.03881896152309 0.133773059352199 no 517 0.149444470527176 677 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2029 5175081 200 µM 1.03630006627994 0.134333918866162 no 518 0.150031087624967 795 1380876 SGTC_1794 st048918 76.9 µM 1.03585273408672 0.134433690862763 no 519 0.150135425642157 688 672303 SGTC_1195 1502-0147 41.1 µM 1.0344003347117 0.134757981554702 no 520 0.15047452400162 798 817940 SGTC_634 1611-4317 11.2 µM 1.03438646108749 0.134761081833547 no 521 0.150477765598636 830 2843522 SGTC_607 4491-0986 66.8 µM 1.03405411005158 0.134835365512671 no 522 0.150555433915744 798 698981 YDR232W HEM1 SGTC_183 3914-0051 30.55 µM 1.03186770981851 0.135324747428816 no 523 0.151067047233337 775 1596232 SGTC_282 k297-0036 65.7 µM 1.03031947468467 0.135672024310145 no 524 0.151430030019817 758 5061378 SGTC_2457 5731572 11.68 µM 1.02939422425205 0.135879853792574 no 525 0.151647231052504 783 2865357 SGTC_1409 3909-8004 61.9 µM 1.02620843255403 0.136597112367443 no 526 0.152396673714712 803 2119279 SGTC_2908 7930301 100 µM 1.02305144331337 0.137310436109775 no 527 0.153141761700482 849 2223178 SGTC_1766 st045414 44.774 µM 1.02167502596712 0.137622233447141 no 528 0.15346736750303 832 253960 SGTC_2811 7967822 32.47 µM 1.02054770132772 0.137877963976088 no 529 0.153734389165881 768 2232244 SGTC_3240 9133527 49.47 µM 1.01803215528918 0.138449776969985 no 530 0.154331337561287 760 17617455 SGTC_1633 st005664 67.9 µM 1.01661222022274 0.138773257387157 no 531 0.154668969267416 782 2063822 SGTC_418 lividomycin a 100 µM 1.01610121447336 0.138889797267826 no 532 0.154790595396048 841 72394 An antibiotic. SGTC_1330 1469-0054 61.8 µM 1.01353585835827 0.139475858816891 no 533 0.155402138675385 845 7102664 SGTC_1392 3455-1037 33.9 µM 1.00873147281238 0.14057795115346 no 534 0.156551716768683 782 981132 SGTC_71 0417-1750 47.813 µM 1.00852914763069 0.14062449247921 no 535 0.156600251037834 833 6811472 SGTC_926 2268-1401 59.4 µM 1.00832388374408 0.140671720487929 no 536 0.156649500372154 791 2931578 SGTC_751 0833-0568 350 µM 1.00792962396146 0.140762463686706 no 537 0.156744124427611 786 6954252 SGTC_1695 st026914 34.495 µM 1.00623983805775 0.141151836251658 no 538 0.157150106400339 794 3289191 SGTC_2877 9040724 71.43 µM 1.0032379653507 0.141845348845696 no 539 0.15787302956867 819 6463895 SGTC_1285 0929-0069 65.5 µM 1.00113657395309 0.142332196999249 no 540 0.158380392597458 796 1206237 SGTC_381 3461-2219 42.7 µM 1.00061539673552 0.142453117544533 no 541 0.158506391756241 827 2883159 SGTC_1433 4060-0023 7.6 µM 0.999832318209285 0.142634933530481 no 542 0.158695831417613 807 3840627 SGTC_88 0180-0332 8.668 µM 0.99736326425908 0.143209228013541 no 543 0.15929410792373 800 3101745 SGTC_641 4092-0595 30 µM 0.993987858474744 0.143996861007191 no 544 0.160114389264097 825 786260 SGTC_74 000s-0487 160.283 µM 0.992754329566911 0.144285425980175 no 545 0.160414845700187 856 677548 SGTC_2907 7721985 69.9 µM 0.990692411997973 0.144768649455031 no 546 0.16091789869866 790 3267881 SGTC_273 hydroxyurea 18.1 mM 0.990304994816618 0.144859564618826 no 547 0.161012532973747 887 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_210 3551-0445 56.827 µM 0.987162672271749 0.145598393579433 no 548 0.161781448896446 810 2865180 YOR207C RET1 SGTC_2606 farnesol 9.78 µM 0.986129565608858 0.145841852103797 no 549 0.162034768488907 816 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_631 k072-0230 41.5 µM 0.985900570061593 0.145895853465297 no 550 0.16209095356484 845 5773147 SGTC_1483 3453-0561 55.9 µM 0.983308531378412 0.146508040677036 no 551 0.162727806258711 850 4546991 SGTC_490 phenamil 164 µM 0.980814670972668 0.14709866543742 no 552 0.16334207106512 715 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_403 arphamenine a 50 µM 0.979852940043533 0.147326859582857 no 553 0.163579357736078 817 5487158 An arginine aminopeptidase inhibitor. SGTC_1776 st049249 45.9 µM 0.979607489875035 0.147385136609352 no 554 0.163639953183586 832 1822314 SGTC_2056 5235370 200 µM 0.97833221435256 0.147688172811196 no 555 0.163955021032374 779 5511916 SGTC_1400 3771-8998 51.5 µM 0.97646140114452 0.148133477711879 no 556 0.164417933363394 789 670767 SGTC_1829 berberine 14.4 µM 0.976461184254158 0.148133529389771 no 557 0.16441798707962 823 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2077 5212015 200 µM 0.976208757734637 0.148193682565998 no 558 0.164480512091917 781 780900 SGTC_2741 miltefosine 3.04 µM 0.975821185919828 0.148286072638901 no 559 0.164576542031552 731 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1993 st073995 70.8 µM 0.975053479543403 0.148469193612156 no 560 0.164766866397971 842 3098394 SGTC_1268 0828-0275 2.46 µM 0.964425254451423 0.151019880393027 no 561 0.167416382904831 880 745337 SGTC_1389 3405-0187 19 µM 0.964297595100371 0.151050693775956 no 562 0.167448373129734 763 799890 SGTC_822 1487-0950 154 µM 0.963444260795103 0.151256772160068 no 563 0.167662311775003 853 1958375 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.962938958240129 0.151378889748351 no 564 0.167789078653379 863 165521 SGTC_1226 3909-7979 35.4 µM 0.951635797343098 0.154127685449414 no 565 0.170640860111146 892 6615510 SGTC_542 3381-0244 89.3 µM 0.945625199947756 0.155602756148193 no 566 0.172169893170803 935 1112843 SGTC_730 1436-0052 41.2 µM 0.945207480483917 0.155705614291055 no 567 0.172276480592125 838 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1329 1447-1697 50.6 µM 0.943982717189058 0.156007455198432 no 568 0.172589240048565 859 2840515 SGTC_159 3970-0959 50 µM 0.943653409481584 0.156088678285046 no 569 0.172673394834486 1033 6615653 SGTC_2855 9016525 58.44 µM 0.941483252941539 0.156624639864933 no 570 0.173228633748935 868 43811474 SGTC_2318 6029776 164 µM 0.93967530345875 0.157072071459976 no 571 0.173692068389115 852 818325 SGTC_704 1310-0270 142 µM 0.939222214360957 0.157184333625639 no 572 0.173808332947552 884 5718033 SGTC_1952 st077036 64.1 µM 0.939175083345057 0.157196014335391 no 573 0.173820429805097 927 2937007 SGTC_2860 9025725 38.96 µM 0.938834769180102 0.157280372995617 no 574 0.173907792254181 805 40546248 SGTC_606 k015-0008 38.6 µM 0.938766156814692 0.157297384552912 no 575 0.17392540919674 946 1970475 SGTC_2712 st079126 47.7 µM 0.93725420075445 0.15767256171289 no 576 0.174313907733428 827 3152970 SGTC_2327 6189656 200 µM 0.936984064131169 0.157739655331404 no 577 0.174383377606346 869 5349088 SGTC_284 0988-0104 32.6 µM 0.936802076617041 0.157784865996709 no 578 0.174430188466707 888 4666532 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.935204036933581 0.158182228122041 no 579 0.174841579240947 736 88881 An O-methylated flavonoid and antioxidant. SGTC_2430 5571206 200 µM 0.932784857668811 0.158785020092264 no 580 0.175465530488696 971 1731771 SGTC_2241 6772625 37.8075 µM 0.932203811049983 0.158930024665694 no 581 0.175615603154537 821 2285411 SGTC_2355 9061122 103.12 µM 0.931606576461047 0.15907915947937 no 582 0.175769941586641 879 5302957 SGTC_442 cape 100 µM 0.930224848777883 0.159424540531375 no 583 0.176127339356795 856 5281787 SGTC_796 1234-0020 70.7 µM 0.929185013174465 0.159684784654225 no 584 0.176396606433524 845 46495034 SGTC_263 alizarin 107.927 µM 0.926964712315481 0.160241398840393 no 585 0.176972428068148 933 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.924360067148137 0.160895980030423 no 586 0.177649439209151 900 688669 SGTC_1674 st016616 23.6 µM 0.924328095358436 0.160904025786256 no 587 0.177657759601563 842 625830 SGTC_499 genistein 192 µM 0.922523658223333 0.16135854118134 no 588 0.178127747881213 880 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1594 piperine 70.1 µM 0.921482733417602 0.161621117741794 no 589 0.178399225946903 872 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.920220245565744 0.161939957835091 no 590 0.178728838295475 951 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1975 st070967 30.8 µM 0.918237770959705 0.16244145622959 no 591 0.179247199134905 954 261391 SGTC_2829 7992743 58.44 µM 0.916222889219846 0.162952187045007 no 592 0.179775001277475 908 16462845 SGTC_2193 5925765 200 µM 0.915515744378438 0.163131680851881 no 593 0.179960470448304 875 877370 SGTC_1135 dihydrocapsaicin 536.708 nM 0.914817597797954 0.163309016645421 no 594 0.180143697394376 828 107982 A Capsaicinoid. SGTC_1758 st042942 75.2445 µM 0.913743336908052 0.163582133540747 no 595 0.180425863304647 892 669317 SGTC_583 1488-1091 88.9 µM 0.913161932437151 0.163730071708186 no 596 0.180578690873448 1052 4303273 SGTC_564 3555-0129 330 µM 0.910586309791465 0.164386482200454 no 597 0.181256693255892 818 563260 SGTC_1568 digitonin 820 nM 0.909541942344816 0.164653130001298 no 598 0.181532064390755 951 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2912 7964298 10.93 µM 0.908556148089309 0.164905079867649 no 599 0.181792231471656 928 2975850 SGTC_670 4204-0025 119 µM 0.907409847845992 0.165198365739188 no 600 0.182095051829192 945 719039 SGTC_522 1273-0010 11.6 µM 0.907288116673948 0.165229531003278 no 601 0.182127228300621 882 5705015 SGTC_3224 9130643 49.47 µM 0.905634914286943 0.165653155824298 no 602 0.18256456121964 870 17644395 SGTC_1514 1189-1591 158 µM 0.905106838760437 0.165788620400799 no 603 0.182704394739166 919 767698 YMR146C TIF34 SGTC_391 gliotoxin 8.33 µM 0.903552113544569 0.166187861959393 no 604 0.183116471500813 959 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.903237479074394 0.166268733183306 no 605 0.183199935211924 943 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_462 ag-879 158 µM 0.902277945595868 0.166515521209021 no 606 0.183454619049327 948 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1729 st035615 45.989 µM 0.901793322670957 0.166640254037635 no 607 0.183583333763395 876 17385451 SGTC_1844 rapamycin 4 nM 0.901454332941984 0.16672753945193 no 608 0.183673402085008 969 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2132 5317594 122.667 µM 0.901232565809274 0.166784657542993 no 609 0.183732339689842 853 794577 SGTC_2463 5473429 200 µM 0.900455622763092 0.166984865691084 no 610 0.183938915707517 882 5399405 SGTC_2062 5245942 200 µM 0.897160434216409 0.167835714899412 no 611 0.18481665718999 999 1376160 SGTC_1650 st011916 45.8 µM 0.892819428718208 0.168960856774211 no 612 0.185976940055219 929 242528 SGTC_326 k292-0812 17.5 µM 0.892766633570994 0.168974570461688 no 613 0.185991079113325 919 3579357 SGTC_2891 9063876 19.48 µM 0.8922568015491 0.169107037545633 no 614 0.18612765141872 879 6472478 SGTC_1623 st003709 20.3 µM 0.890691278215896 0.169514216232349 no 615 0.186547407552686 943 16192618 SGTC_1798 st045719 60.953 µM 0.890467680726306 0.16957242324715 no 616 0.186607407463495 876 3980186 SGTC_2905 7799065 20.05 µM 0.890254580426478 0.16962790956049 no 617 0.186664601689029 890 1296806 SGTC_1429 4049-0205 9.46 µM 0.889235616465219 0.16989338481218 no 618 0.186938232544026 960 22774478 SGTC_3339 9145883 14.936 µM 0.887158065508531 0.170435483234432 no 619 0.1874969029407 875 2030670 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.885980620712497 0.170743206913888 no 620 0.187813985061604 967 5393153 SGTC_2113 5491891 107.031 µM 0.88487931861517 0.171031352441963 no 621 0.188110861738679 927 789979 SGTC_1452 4194-0072 190 µM 0.884458936193463 0.171141423601194 no 622 0.188224260056548 1000 1343545 SGTC_2012 4023501 200 µM 0.883794549202205 0.171315476241759 no 623 0.188403564688188 849 3477460 SGTC_595 3909-8003 73.7 µM 0.883365313009733 0.171427985452542 no 624 0.188519462868579 941 699517 SGTC_527 4476-4215 268 µM 0.882551850053125 0.171641335755321 no 625 0.188739226798007 904 4418754 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.882374828292424 0.171687786451127 no 626 0.18878707164211 967 6708739 YPR165W RHO1 SGTC_858 0438-0351 2.77 µM 0.881870093676681 0.171820273429187 no 627 0.188923530644964 970 2799119 SGTC_2102 5377816 72.7585 µM 0.881709130986692 0.171862537994376 no 628 0.188967060960545 978 1379702 SGTC_904 1141-0088 396 µM 0.879316101805572 0.172491667357826 no 629 0.189614953897248 904 1378119 SGTC_2380 9035439 200 µM 0.878324619202426 0.172752758750728 no 630 0.189883789552603 996 6462575 SGTC_1949 st076024 69.1 µM 0.877513096295203 0.172966647951292 no 631 0.190104004326454 979 2921930 SGTC_106 0092-0003 11.579 µM 0.877342263198642 0.173011695099977 no 632 0.190150381567133 886 1072148 SGTC_1579 chlormadinone acetate 49.4 µM 0.876495051124837 0.173235207724602 no 633 0.190380482796518 962 45114258 A steroidal progestin. SGTC_2565 isoliquiritigenin 100 µM 0.876362386122779 0.173270224226744 no 634 0.190416529844962 764 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1820 st053765 18.6 µM 0.875973358522467 0.173372932798033 no 635 0.190522258577627 916 3690829 SGTC_2982 9019404 25.97 µM 0.871480940566979 0.174561799076682 no 636 0.191745804062044 878 22333232 SGTC_1103 duloxetine 36.1 µM 0.868165500427263 0.175442504030907 no 637 0.192651868841348 1048 60835 A selective serotonin reuptake inhibitor. SGTC_905 2-aminofluorene 215 µM 0.865943515938967 0.176034319838507 no 638 0.193260568907918 1024 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1618 st003135 44.5 µM 0.865824345064451 0.176066096149198 no 639 0.193293248224572 941 1270615 SGTC_2364 9055074 200 µM 0.864815382811464 0.176335276336971 no 640 0.193570063340553 894 6470630 SGTC_3128 9127691 49.47 µM 0.862752237703359 0.17688651119805 no 641 0.194136852303654 844 41316314 SGTC_2988 9073640 71.4286 µM 0.862017547345531 0.177083069782343 no 642 0.194338930905181 908 9102229 SGTC_3148 9097893 49.47 µM 0.861962649887332 0.177097762551321 no 643 0.194354035742585 930 17174100 SGTC_703 3875-0075 71.8 µM 0.861509877967605 0.177218971904783 no 644 0.194478641558325 1012 2850814 SGTC_2313 7726885 200 µM 0.860934810861535 0.177372995817236 no 645 0.194636973898089 910 726423 SGTC_603 3794-0023 45.9 µM 0.859353964365859 0.177796839429557 no 646 0.195072629921675 963 3802260 SGTC_406 estrone 100 µM 0.858569930895567 0.178007284868447 no 647 0.195288916733081 981 5870 A steroid. SGTC_2487 5918373 44.05 µM 0.858273603641866 0.178086864087906 no 648 0.195370700758071 1023 2876279 SGTC_5 0352-0601 109.883 µM 0.857067038280547 0.178411120928866 no 649 0.195703918221092 917 762456 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.855239803292516 0.178902886497914 no 650 0.1962092025293 968 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2007 4011539 71.82 µM 0.853656697730529 0.179329638314158 no 651 0.196647616794629 942 45595301 SGTC_2619 obliquin 87.91 µM 0.852237864387758 0.179712651322969 no 652 0.197041042456618 1004 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1052 3253-3998 198 µM 0.851468156497542 0.17992064827904 no 653 0.197254672503013 1022 5450317 SGTC_3323 9138564 53.9225 µM 0.85051856085555 0.180177464242955 no 654 0.197518422813543 1053 43912313 YNL103W MET4 SGTC_1005 4092-0690 4.4 µM 0.849496433169698 0.180454153321366 no 655 0.197802557047825 919 1529343 SGTC_2394 5221648 200 µM 0.84745986527638 0.181006244614547 no 656 0.198369424268901 1053 788586 SGTC_180 1486-1293 102.781 µM 0.846344623183208 0.181309022548123 no 657 0.198680260607354 987 4140536 SGTC_1016 4226-1401 38 µM 0.842775730110229 0.182280073767317 no 658 0.199676941978978 1008 2901613 SGTC_435 c-PAF 6.7 µM 0.842382092432389 0.182387376307098 no 659 0.199787056700018 972 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_189 3970-0742 2.116 µM 0.840946163925399 0.182779133592988 no 660 0.200189047479427 997 2891807 SGTC_2046 4110841 106 µM 0.840713689452962 0.182842607826077 no 661 0.200254174817865 1005 44119630 YMR134W ERG29 SGTC_477 mead ethanolamide 10 µM 0.84047282747799 0.182908386671471 no 662 0.200321665328477 861 16061185 SGTC_1793 st048256 72.231 µM 0.838151051162851 0.183543215491758 no 663 0.200972937058691 963 672022 SGTC_288 1315-0019 35.1 µM 0.837683035167023 0.18367134829475 no 664 0.201104371929896 1002 6811474 SGTC_1003 4049-0218 100 µM 0.837603399744182 0.18369315632321 no 665 0.201126741406797 986 295161 SGTC_1799 st045822 46.1415 µM 0.836216361866746 0.184073253065528 no 666 0.20151659766299 981 3674992 SGTC_2808 7946468 45.46 µM 0.836067080634878 0.184114190492106 no 667 0.201558583274086 986 2970879 SGTC_1166 k206-0078 225 µM 0.835652315583495 0.18422796135259 no 668 0.201675264186626 1013 5404595 SGTC_3084 9116877 49.47 µM 0.835450291746346 0.184283392726197 no 669 0.201732111796229 926 27241325 SGTC_2001 4023502 57.655 µM 0.835000886461533 0.18440673792823 no 670 0.201858604634398 969 108941 YCR052W RSC6 SGTC_3147 9097027 49.47 µM 0.83398811114283 0.184684895693994 no 671 0.202143841687917 1018 25236841 SGTC_2365 9042475 200 µM 0.833818888894611 0.184731397843321 no 672 0.202191524780027 988 6464479 SGTC_584 0986-0246 15.4 µM 0.830536533642817 0.185634826084202 no 673 0.203117750502269 1110 53315 YDR232W HEM1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.830438526183966 0.185661843523376 no 674 0.203145445457764 985 616764 SGTC_1569 carminic acid 40.6 µM 0.828210474917817 0.186276702124527 no 675 0.203775656309906 1023 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1373 2887-0003 58.5 µM 0.827494365583759 0.186474589069625 no 676 0.203978457167752 969 776948 SGTC_847 0342-0274 5.54 µM 0.826953748724001 0.186624067304815 no 677 0.20413163851001 1041 18097 SGTC_665 3914-0008 307 µM 0.825396992917228 0.187054917833379 no 678 0.20457312079157 1000 1069549 SGTC_857 0438-0306 1.35 µM 0.825088848833887 0.187140273235963 no 679 0.204660575059364 1011 4686136 SGTC_3275 9138069 49.47 µM 0.82371322242391 0.187521613211724 no 680 0.205051262316092 995 17617007 SGTC_705 1124-0212 310 µM 0.823646825398263 0.187540031395814 no 681 0.205070130730653 1006 9554485 SGTC_3218 9131285 49.47 µM 0.823551772077006 0.187566400630498 no 682 0.205097144361229 1043 17156417 SGTC_2667 digitoxin 100 µM 0.823212358646535 0.187660577764619 no 683 0.205193621046496 972 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3043 9092303 49.47 µM 0.822097048596967 0.18797024879862 no 684 0.205510832559856 991 25236084 SGTC_708 3448-5400 146 µM 0.821696394028291 0.188081569385091 no 685 0.205624855993516 1024 3462195 SGTC_2966 9084041 48.03 µM 0.821209337670301 0.188216951219446 no 686 0.20576351932221 960 17741380 SGTC_2678 equilin 100 µM 0.821080312858134 0.1882528249351 no 687 0.205800261552506 1049 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2999 9069765 71.4286 µM 0.820378784908219 0.188447949718413 no 688 0.206000102883313 1044 2097066 SGTC_2017 5132927 60.65 µM 0.819554517559067 0.188677372866213 no 689 0.20623505546955 1044 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_712 r015-0009 80.6 µM 0.818647072764497 0.188930146296634 no 690 0.206493900910646 952 6813872 YLR060W FRS1 SGTC_1413 3910-0535 34.4 µM 0.81830304829899 0.189026030603444 no 691 0.206592082972416 1043 2876951 SGTC_803 4488-1585 147 µM 0.818032221064069 0.189101534927203 no 692 0.20666939452801 992 747204 SGTC_366 0181-0206 4.31 µM 0.817384034538208 0.189282319214803 no 693 0.20685449831404 1031 274874 SGTC_922 1866-0035 480 µM 0.81721196112921 0.189330329699757 no 694 0.206903654103927 1075 3156169 SGTC_2661 dactinomycin 12.96 µM 0.817211722268654 0.189330396349843 no 695 0.206903722343443 1043 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1661 st013063 9.66 µM 0.815118895329638 0.189914919415611 no 696 0.207502128391488 1084 721395 SGTC_1600 coumarin 106 71.1 µM 0.814297422737107 0.190144658216974 no 697 0.207737292907972 1037 100336 A hepatotoxic, DNA x-linker. SGTC_2700 st077718 96.8 µM 0.812517204236456 0.190643112358363 no 698 0.208247459376952 960 904970 SGTC_557 1315-0110 16.2 µM 0.811141990138801 0.191028715437712 no 699 0.208642067231256 1076 6833801 SGTC_1362 1611-0397 101 µM 0.811059845874334 0.191051763403348 no 700 0.208665651882781 1042 27816 SGTC_467 ro 31-8220 72.8 µM 0.810559527111472 0.19119217922496 no 701 0.208809333622156 1012 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_807 1315-0151 48 µM 0.806031098428891 0.192465971082681 no 702 0.21011245901101 1090 4011080 SGTC_455 paf C-16 10 µM 0.805890473312078 0.192505610098891 no 703 0.210153002397658 983 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2215 7188065 200 µM 0.804800668765003 0.192812970344496 no 704 0.210467357846872 1033 940217 SGTC_319 1348-1596 45.5 µM 0.80473613787574 0.192831179545985 no 705 0.21048598051188 1052 5380505 SGTC_405 ebelactone b 50 µM 0.804370443947954 0.192934390194901 no 706 0.210591532666414 1011 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1229 0139-0193 12.2 µM 0.804191176507127 0.192984997583457 no 707 0.210643286909931 1082 3090752 SGTC_2296 7971656 126.45 µM 0.804106391317375 0.193008935355778 no 708 0.210667766867192 1037 666570 SGTC_1472 k841-0093 193 µM 0.804015680095593 0.193034548258148 no 709 0.210693959690815 1084 X1472 SGTC_2965 9082772 38.63 µM 0.801990917607423 0.193606793139103 no 710 0.211279106013386 1072 16459634 SGTC_1664 st014217 9.02 µM 0.801640122827878 0.193706040928841 no 711 0.211380580639636 1135 3982782 SGTC_1222 0366-0074 1.18 µM 0.801167215217909 0.193839886291562 no 712 0.21151742409142 1095 286520 SGTC_865 0488-0499 301 µM 0.800362291806134 0.194067830500054 no 713 0.211750460917778 1086 9634651 SGTC_2890 9046729 58.44 µM 0.797055073850263 0.195006105802067 no 714 0.212709523317271 966 903329 SGTC_763 3453-1109 128 µM 0.796861889796886 0.195060998266407 no 715 0.21276562318385 1068 1560353 SGTC_3013 9080133 71.4286 µM 0.795775060939916 0.195369991306884 no 716 0.213081394832377 1099 17050193 SGTC_1941 st076221 61.8 µM 0.795121294022667 0.195556004956985 no 717 0.21327147453107 1072 2828568 SGTC_149 3970-0822 46.1 µM 0.794999384540752 0.195590703260552 no 718 0.213306930081552 1131 3114250 YBL034C STU1 SGTC_1344 1488-0097 29.1 µM 0.793644163336612 0.195976682776503 no 719 0.213701307303963 1026 747966 SGTC_1156 4092-0367 4.88 µM 0.793305289398585 0.196073269375589 no 720 0.213799987923346 1041 1357585 SGTC_1597 7-benzyloxygramine 47.5 µM 0.79208247740172 0.196422037952923 no 721 0.214156293259188 1086 260807 SGTC_3308 9128332 17.569 µM 0.791973706549505 0.196453079609309 no 722 0.214188003846618 1085 17332805 YDL196W YDL196W SGTC_1457 k015-0032 57.3 µM 0.791362101582147 0.196627678330249 no 723 0.214366359395162 1023 4302660 SGTC_1048 3161-0300 24.5 µM 0.78929446004746 0.197218636707629 no 724 0.214969961905409 1114 2165101 SGTC_422 cantharidin 155 µM 0.789085132901923 0.197278524922064 no 725 0.21503112533875 1040 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2353 9059630 146.67 µM 0.787792322779146 0.197648639875076 no 726 0.215409096214556 1079 4779114 SGTC_3189 9110682 49.47 µM 0.78708926687098 0.197850091820926 no 727 0.215614806001225 1052 17122418 SGTC_778 3456-2434 196 µM 0.786687102542534 0.197965382771991 no 728 0.215732527980771 1132 5539063 SGTC_207 4185-0010 4.486 µM 0.786570366842391 0.197998855718784 no 729 0.215766705957788 1136 3761753 SGTC_49 0717-0965 32.132 µM 0.785401492711545 0.198334208641842 no 730 0.216109102925178 1156 5889349 YGL099W LSG1 SGTC_2953 9074162 66.49 µM 0.785256755633911 0.198375757909886 no 731 0.216151522477203 999 16451992 SGTC_1510 1123-0200 71.5 µM 0.784323091515303 0.198643908458728 no 732 0.216425276670302 1106 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2285 7945142 200 µM 0.782273884328999 0.199233211498162 no 733 0.21702681568613 1042 2970608 SGTC_1886 st057356 49.9 µM 0.781555294727034 0.199440109799669 no 734 0.21723798424051 1016 24207747 SGTC_22 0964-0034 14.468 µM 0.780710465643336 0.199683520674469 no 735 0.217486401916283 1097 138402 SGTC_1094 duloxetine 25.4 µM 0.778379646761662 0.200355998887877 no 736 0.218172616969219 1068 60834 A selective serotonin reuptake inhibitor. SGTC_2520 obtusaquinone 4.71 µM 0.777807583587351 0.200521255892195 no 737 0.218341228267271 1107 5967872 SGTC_2703 st077852 53.4 µM 0.77754317098072 0.200597666779369 no 738 0.218419187244581 1032 6281836 SGTC_2247 cerulenin 830 nM 0.774908295459699 0.201360057122777 no 739 0.219196924987993 1124 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_652 0437-0092 114 µM 0.772674269592913 0.202007821820335 no 740 0.219857589039036 1070 3091274 SGTC_1545 lovastatin 49.4 µM 0.765287785333028 0.204158424216931 no 741 0.222050097942878 1132 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_214 4373-3496 70 µM 0.762800468332686 0.204885673774326 no 742 0.222791200888972 1208 3779166 SGTC_265 mycophenolic acid 32.932 µM 0.761397593010262 0.205296529387491 no 743 0.22320981234508 1164 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.759940784285215 0.205723697889231 no 744 0.223644990778971 1033 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_725 1497-0963 19 µM 0.759340282538233 0.205899931684156 no 745 0.223824513205889 1124 3549977 SGTC_480 am 92016 50 µM 0.758803910755718 0.206057420470508 no 746 0.223984932950266 1042 2129 K+ channel blocker. SGTC_1407 3909-7909 12.3 µM 0.757428090973905 0.206461713362113 no 747 0.224396715960026 1120 4411780 SGTC_2472 5377652 49.4 µM 0.756814728793056 0.206642104870975 no 748 0.224580433715132 1088 1610903 SGTC_476 mead acid 10 µM 0.752709388669717 0.207851897807727 no 749 0.225812283435298 1114 5312531 An omega 9 fatty acid. SGTC_760 0568-0725 82.9 µM 0.75248291782309 0.207918757475026 no 750 0.225880349393261 1132 3916171 SGTC_684 1140-0066 328 µM 0.752310244572903 0.207969743322895 no 751 0.225932254243529 1138 6813534 SGTC_3249 9135183 49.47 µM 0.751401384647729 0.208238227292134 no 752 0.22620556483698 1156 4902779 SGTC_3068 9116768 49.47 µM 0.751254750548103 0.208281563244702 no 753 0.226249677853558 1096 41904888 SGTC_2238 6671620 73.2395 µM 0.750581785786136 0.20848051815454 no 754 0.226452193126264 1123 729941 SGTC_920 mycophenolic acid 780.421 nM 0.749671286006042 0.208749876086764 no 755 0.226726352666181 1071 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1033 k072-0102 21.3 µM 0.748494826609045 0.209098217778378 no 756 0.227080872192143 1110 5965931 SGTC_2164 5685496 200 µM 0.747735484465722 0.209323235511578 no 757 0.227309861605084 1119 759046 SGTC_801 0866-0028 10.1 µM 0.741117756595427 0.211290308383454 no 758 0.229311022071725 1163 6849771 SGTC_2690 usnic acid 100 µM 0.74104393328311 0.211312312741512 no 759 0.229333401353813 1171 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1217 1183-1422 255 µM 0.740362414232471 0.211515515070529 no 760 0.229540059315369 1178 2849664 SGTC_2118 5526350 200 µM 0.740354469574562 0.211517884531274 no 761 0.22954246900004 1117 743594 SGTC_2698 st077697 67.5 µM 0.739674014325331 0.211720885106621 no 762 0.229748909653212 1076 3154499 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.737331166851519 0.212420699582812 no 763 0.230460491654653 1131 97141 SGTC_3274 9138298 49.47 µM 0.736612438680833 0.212635656105046 no 764 0.230679034254029 1133 17015756 SGTC_981 1488-1094 54.9 µM 0.735762474761898 0.212890026351971 no 765 0.230937630866708 1112 3449522 SGTC_2219 9098279 200 µM 0.734713778731566 0.213204116124033 no 766 0.231256913494075 1139 902349 SGTC_127 0180-0333 59.125 µM 0.734164997614054 0.21336858650294 no 767 0.231424091729708 1128 771601 SGTC_963 1269-2853 151 µM 0.732887694881516 0.213751682006656 no 768 0.231813464389138 1124 3668223 SGTC_1276 0871-0068 94.2 µM 0.731121190900848 0.214282160984041 no 769 0.232352565894305 1110 3414906 SGTC_2351 9026858 72.31 µM 0.730052805695204 0.214603367053004 no 770 0.232678953744103 1106 1409300 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.728984283850485 0.214924893944408 no 771 0.233005638059999 1137 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1788 fluconazole 20 µM 0.728366527859179 0.215110909301179 no 772 0.233194623708668 1107 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_913 3487-1245 167 µM 0.72820041239135 0.215160945037174 no 773 0.233245456731325 1114 4016153 SGTC_3119 9125183 49.47 µM 0.727279877663902 0.21543834225899 no 774 0.23352726116071 1010 22695334 SGTC_3109 9122853 49.47 µM 0.727183934276383 0.215467266115494 no 775 0.233556643290177 1180 1234709 SGTC_52 0329-0193 875 nM 0.727178105845727 0.215469023273115 no 776 0.23355842828074 1188 3739292 SGTC_1426 4048-4480 71.7 µM 0.727104601665539 0.215491184056361 no 777 0.233580940009924 1140 14224343 SGTC_1341 1486-1360 280 µM 0.725669540749277 0.215924105513087 no 778 0.234020689364233 1158 3976547 SGTC_666 0272-0154 136 µM 0.725517885768438 0.21596988539543 no 779 0.234067188160517 1166 6870312 SGTC_966 1300-0360 30.2 µM 0.725257220721966 0.216048585135518 no 780 0.234147122388837 1152 70588 SGTC_1129 3453-1384 223 µM 0.724094994040385 0.216399685591724 no 781 0.234503708838842 1174 1084452 SGTC_2563 tomatine 8.54 µM 0.722921746560369 0.216754450061778 no 782 0.234863981113948 1154 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1733 st037357 54.9 µM 0.722662707241905 0.216832823207577 no 783 0.23494356622456 1154 1272339 YGL099W LSG1 SGTC_211 3455-0679 143.504 µM 0.72211214229485 0.216999452738701 no 784 0.235112766756756 1184 748649 SGTC_573 3702-0553 84.7 µM 0.722045091497253 0.21701975084432 no 785 0.235133377515476 1132 1222756 SGTC_3193 9111931 49.47 µM 0.721401189034115 0.217214733541871 no 786 0.235331357625812 1187 17087244 SGTC_2738 aclarubicin 5.55 µM 0.721394498499012 0.217216760060782 no 787 0.235333415241539 1064 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2136 5328288 199.296 µM 0.720061736702891 0.217620662524255 no 788 0.235743492479861 1093 262395 SGTC_2936 9038235 15.59 µM 0.719257140334119 0.217864710541683 no 789 0.235991249212132 1167 4749415 SGTC_814 3342-0569 96 µM 0.717834622904421 0.218296570715699 no 790 0.236429631245628 1187 4346283 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.717432072492047 0.218418869930713 no 791 0.236553767897471 1168 5357218 A potent inhibitor of glutathione S-transferases. SGTC_869 0564-0080 44.1 µM 0.716393736448851 0.218734509879001 no 792 0.236874130709468 1145 6843321 SGTC_784 4579-0127 173 µM 0.715283173797021 0.21907239608351 no 793 0.237217041783525 1208 1948547 SGTC_951 1171-0579 82.7 µM 0.714538928141983 0.219298999027478 no 794 0.23744699680062 1185 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_16 erodoxin 22.806 µM 0.712874045459063 0.219806398823551 no 795 0.237961850548022 1214 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2879 9041815 71.43 µM 0.712344247961761 0.219968004370523 no 796 0.238125815125913 1119 4942971 SGTC_2960 9079389 5.97 µM 0.711950929850962 0.220088023326272 no 797 0.238247581360428 1153 16457355 SGTC_593 1203-0218 61.7 µM 0.711338862304496 0.220274867213458 no 798 0.238437137432671 1213 3666956 SGTC_548 1436-0017 110 µM 0.710083075252101 0.220658501864904 no 799 0.23882631051333 1225 9677137 SGTC_2396 5342950 42.78 µM 0.709863034077207 0.220725762375567 no 800 0.238894537847857 1166 1886677 SGTC_2427 5545055 42.75 µM 0.707754120865998 0.221370994192369 no 801 0.239548980920278 1203 5372858 SGTC_2344 7990960 76.95 µM 0.707212314486882 0.221536936351604 no 802 0.239717273483494 1166 140813 SGTC_228 caffeine 993.056 µM 0.706228557494615 0.221838418949272 no 803 0.240023006879333 1173 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1888 azatryptophan 97.5 µM 0.706057407890601 0.221890893452437 no 804 0.240076218699831 1138 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_590 k048-0076 22.4 µM 0.706017778660152 0.221903044793143 no 805 0.240088540670643 1164 6832814 SGTC_3212 9128307 49.47 µM 0.705317156499357 0.222117936296927 no 806 0.240306442995345 1126 27243542 SGTC_342 k048-0088 23.3 µM 0.704390120513629 0.222402454851155 no 807 0.24059492840377 1173 6820570 SGTC_3352 9151559 45.5865 µM 0.704066115784613 0.222501944822355 no 808 0.240695800259365 1162 17159339 SGTC_2184 6075246 200 µM 0.704008756560167 0.222519560380635 no 809 0.240713660209552 1183 2267320 SGTC_2570 licareol 100 µM 0.703910340304216 0.222549786792861 no 810 0.240744305774035 1143 443158 SGTC_2464 5717415 7.67 µM 0.7020372775983 0.22312550334999 no 811 0.241327958107162 1136 5285744 SGTC_1556 plumbagin 1.48 µM 0.701703049661851 0.22322832287294 no 812 0.241432185377421 1119 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2182 6325192 200 µM 0.700566816999617 0.223578067089055 no 813 0.24178669650277 1138 736248 SGTC_1659 st012954 42.1 µM 0.698866175357946 0.224102124094392 no 814 0.242317833885802 1160 24207262 SGTC_2763 lisinopril 49.32 µM 0.697911893917933 0.224396493650991 no 815 0.242616147838343 1161 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2635 hydroquinidine 100 µM 0.696862744758043 0.224720380414977 no 816 0.242944347352194 1172 442912 An experimental heart treatment. SGTC_2895 9054447 58.44 µM 0.696468162780594 0.224842261866454 no 817 0.243067844369672 1220 2697450 SGTC_2218 6965428 192.983 µM 0.693803983809998 0.225666173658598 no 818 0.24390257196987 1177 675684 SGTC_2797 7859098 81.82 µM 0.693171132325862 0.22586213718868 no 819 0.244101081028388 1228 972681 SGTC_2800 7887935 81.82 µM 0.692987093310818 0.22591914323701 no 820 0.244158825632581 1177 2961002 SGTC_624 k048-0052 28 µM 0.691577404403726 0.226356063814569 no 821 0.244601377819218 1164 6835531 SGTC_1105 epirubicin 18.1 µM 0.69090209585539 0.226565538672019 no 822 0.244813534477485 1172 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3055 9094636 49.47 µM 0.688053063866945 0.227450487412256 no 823 0.245709683021701 1243 25236176 SGTC_3335 9143315 29.6265 µM 0.688027176594694 0.227458537272651 no 824 0.245717833798964 1190 4899691 SGTC_1385 3091-4834 14.1 µM 0.687491338002969 0.227625196726142 no 825 0.245886578688214 1170 4072814 SGTC_231 b-estradiol 524 µM 0.686450284937556 0.227949187210936 no 826 0.246214602117892 1161 450 A steroid. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.686067226838895 0.228068465583864 no 827 0.24633535819205 1223 5282362 SGTC_3048 9093155 49.47 µM 0.6855487674641 0.228229961712618 no 828 0.246498849010023 1186 25236002 SGTC_1835 st008666 49.2 µM 0.684174232007348 0.228658429985882 no 829 0.246932575831132 1152 690455 SGTC_1319 1306-0155 43.7 µM 0.683121314207184 0.228986949353627 no 830 0.247265094082499 1252 3122360 SGTC_2656 pseudo-anisatin 100 µM 0.682365889461351 0.229222811409586 no 831 0.247503809521198 1236 6708809 A neurotoxin. SGTC_1702 st027038 51 µM 0.681515017614517 0.22948863744124 no 832 0.24777283378769 1225 5521182 SGTC_493 zm226600 134 µM 0.680479035325064 0.229812528029548 no 833 0.248100595971266 1245 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1354 1498-1681 81 µM 0.67932512627786 0.230173588478499 no 834 0.248465939704727 1265 5754243 SGTC_1374 2889-5571 141 µM 0.678407696647024 0.230460880341689 no 835 0.248756615205089 1218 2853281 SGTC_2160 5660466 132.927 µM 0.678094280130628 0.230559072220677 no 836 0.248855958580968 1173 2859134 SGTC_1742 st038235 28.8875 µM 0.675862690213533 0.231258894038266 no 837 0.249563913910216 1205 564103 YBR002C RER2 SGTC_2431 5490079 200 µM 0.674789464833861 0.231595876736031 no 838 0.249904767337227 1253 5722345 SGTC_1619 st003326 88.7 µM 0.674687794078768 0.231627814584857 no 839 0.24993707049724 1201 2849032 SGTC_1717 st033143 58.0435 µM 0.674490759476595 0.231689716080002 no 840 0.249999679274407 1245 674616 SGTC_2297 7971671 152.32 µM 0.674467167752248 0.231697128406271 no 841 0.250007176226256 1244 909016 SGTC_3344 9148862 3.898 µM 0.67429901373996 0.231749964844915 no 842 0.250060615475945 1264 4905352 SGTC_2066 5222451 176 µM 0.672220572684768 0.232403595285425 no 843 0.250721642943013 1245 2281147 SGTC_2925 9010536 32.5 µM 0.671895033136193 0.232506064121022 no 844 0.25082526130718 1237 2994177 SGTC_3123 9126162 49.47 µM 0.671714743938531 0.232562823868272 no 845 0.250882656627772 1288 25239884 SGTC_1868 st057644 42.7 µM 0.671614620164017 0.232594348773876 no 846 0.250914534174886 1242 688665 SGTC_2073 5212005 126 µM 0.671069276368033 0.232766097064985 no 847 0.25108819912491 1122 691789 SGTC_1082 camptothecin 424.86 nM 0.66889316537652 0.233452133538609 no 848 0.251781815166836 1180 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1846 st056244 14.8 µM 0.66708447890594 0.234023188968659 no 849 0.252359086850928 1246 5393182 SGTC_2793 7325131 81.82 µM 0.665695788408295 0.234462163900492 no 850 0.252802783014128 1221 4176441 SGTC_817 1391-0715 46 µM 0.665690024988742 0.234463986707149 no 851 0.252804625321725 1210 1353946 SGTC_1614 st002383 48.6 µM 0.664412216860699 0.234868314804157 no 852 0.253213257904323 1250 1947235 SGTC_692 k241-0027 77.8 µM 0.663767694034974 0.235072402876405 no 853 0.253419502734808 1305 3600480 SGTC_1227 3909-8010 46.6 µM 0.663587063006835 0.235129617238238 no 854 0.253477319805152 1234 15982272 SGTC_1521 st012942 49.4 µM 0.661019705135106 0.235943651490926 no 855 0.254299838334067 1290 24207259 SGTC_2748 diazoxide 86.69 µM 0.660005248804839 0.236265733602299 no 856 0.254625230522767 1209 3019 A potassium channel activatior. SGTC_2723 salbutamol 83.58 µM 0.655811549373964 0.237599766806852 no 857 0.255972692200468 1251 9884233 β2-adrenoceptor agonist SGTC_83 0170-0301 39.027 µM 0.655148941224223 0.237810922699806 no 858 0.256185932153096 1219 3089716 SGTC_2581 avocatin a 64 µM 0.654362085890923 0.238061806540159 no 859 0.256439277476281 1265 6710728 A skin care supplement. SGTC_2352 9027995 87.8 µM 0.653335037807517 0.238389492447471 no 860 0.256770154408031 1238 2997347 SGTC_782 0083-0095 30.5 µM 0.653210127878634 0.238429362556349 no 861 0.256810410922515 1267 3591729 An indicator and reagent. SGTC_1360 1598-0022 39.8 µM 0.651948106772533 0.238832392900969 no 862 0.257217324752788 1300 761525 SGTC_1809 st050081 57.6 µM 0.65078600273459 0.239203843722793 no 863 0.257592318511092 1326 5036894 SGTC_2840 9008771 71.43 µM 0.6492639536703 0.239690823208465 no 864 0.25808389028022 1240 2992978 SGTC_1293 1000-1278 195 µM 0.64867118758699 0.239880624956033 no 865 0.258275465756391 1328 678847 SGTC_2505 galangin 7.89 µM 0.647586571264825 0.240228127663437 no 866 0.25862619253068 1222 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.646589200221003 0.240547919621009 no 867 0.258948924750249 1295 4213774 SGTC_3173 9105693 49.47 µM 0.645491696703973 0.240900085239941 no 868 0.259304298714896 1315 17096658 SGTC_12 0849-0099 9.267 µM 0.645327626581292 0.240952755951961 no 869 0.259357446613356 1214 6071388 SGTC_46 0329-0187a 2.197 µM 0.644891623245046 0.241092754624443 no 870 0.25949871028325 1292 46494817 SGTC_1031 k035-0009 16 µM 0.640401992361792 0.24253692361252 no 871 0.260955643957067 1299 5180959 SGTC_1530 rhein 70.4 µM 0.639545403122625 0.242812991905026 no 872 0.261234093476644 1313 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1906 st060206 94.7 µM 0.638916467490463 0.243015798430387 no 873 0.261438637306732 1273 5133468 SGTC_2253 7938677 135.83 µM 0.638154408337275 0.243261654667733 no 874 0.261686586009541 1369 2301972 SGTC_1042 0350-0096 82 µM 0.638105937886921 0.243277296796184 no 875 0.261702360762516 1285 3122515 SGTC_1676 st018489 23.4 µM 0.638060748456093 0.24329188058098 no 876 0.261717068144134 1312 3696235 SGTC_520 3584-0023 682 µM 0.637855961026892 0.24335797664305 no 877 0.261783723709532 1258 1340790 SGTC_3007 9078383 71.4286 µM 0.63720779118335 0.243567240315121 no 878 0.261994751698986 1267 6496995 SGTC_3102 9121669 49.47 µM 0.634516000708951 0.244437332253278 no 879 0.262872063943995 1320 41905072 SGTC_250 brefeldin a 552.239 µM 0.634505231443285 0.244440816661419 no 880 0.262875576893191 1212 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_160 3453-0671 289.699 µM 0.631116637683476 0.245538527899428 no 881 0.263982131638855 1240 5322268 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.63066840971824 0.245683926263022 no 882 0.264128679302916 1290 7104 SGTC_393 acivicin 6.25 µM 0.629861128235899 0.245945912729298 no 883 0.2643927236365 1247 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2395 5646831 180.19 µM 0.62776435443246 0.246627076952319 no 884 0.265079160177549 1342 6808628 SGTC_1743 st037606 46.3785 µM 0.627295606265345 0.246779493963874 no 885 0.265232741496246 1333 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3046 9092212 49.47 µM 0.627252242333123 0.246793596622379 no 886 0.265246951599658 1319 25236637 SGTC_1490 4089-0339 670 nM 0.623753581984952 0.247932838409169 no 887 0.266394714044976 1270 742542 SGTC_1900 st060200 72.8 µM 0.621686225407969 0.248607332658872 no 888 0.26707410542823 1303 688945 SGTC_360 0957-0399 1.01 µM 0.620422047046888 0.249020263665858 no 889 0.26748998052999 1333 6752301 YPR165W RHO1 SGTC_2536 dehydroabietamide 32.04 µM 0.618292971322265 0.249716528623093 no 890 0.268191117121702 1373 3983547 SGTC_287 k060-0039 29.6 µM 0.618212451573321 0.249742881017678 no 891 0.268217651620874 1354 5861974 SGTC_3284 9108171 64.8615 µM 0.617795617456607 0.249879325530292 no 892 0.268355036360731 1296 8687505 SGTC_415 dibenzyl ketone 100 µM 0.617249756198703 0.250058064998388 no 893 0.26853500078021 1381 7593 SGTC_2477 5967686 25.23 µM 0.616962221071856 0.250152244169204 no 894 0.268629822320071 1293 776118 SGTC_25 0118-0223 35.662 µM 0.613445212229126 0.251305725017158 no 895 0.269790999391916 1353 5333628 SGTC_2676 harmalol 100 µM 0.61285741829113 0.251498778934391 no 896 0.269985310520693 1358 5459187 A monoamine oxidase inhibitor SGTC_3140 9094243 49.47 µM 0.611317709105594 0.252004849338313 no 897 0.270494634669893 1333 19291112 SGTC_622 1348-1566 26.3 µM 0.608808908460603 0.252830589599982 no 898 0.271325554045346 1373 7340407 SGTC_960 1222-0186 7.7 µM 0.608441966929228 0.252951483090758 no 899 0.271447192300926 1360 3126296 SGTC_2205 7238770 200 µM 0.605799162529685 0.253823085908939 no 900 0.272324062957786 1363 279867 SGTC_2941 9056145 11.23 µM 0.605225496990826 0.254012490132124 no 901 0.272514588336815 1235 2119517 SGTC_1966 st070145 16.1 µM 0.605217244561393 0.254015215335572 no 902 0.272517329610461 1260 3748532 SGTC_3295 9122362 53.5725 µM 0.605046207925869 0.254071700293379 no 903 0.272574147261737 1324 4730473 SGTC_192 3455-0609 60.9 µM 0.604729589843789 0.25417628100246 no 904 0.272679341974295 1354 3769639 SGTC_715 0868-0130 184 µM 0.604485965659982 0.254256766787629 no 905 0.272760298556628 1419 2876258 SGTC_2929 9013348 24.6 µM 0.602534069956167 0.254902093967133 no 906 0.273409345814304 1341 2995952 SGTC_1355 1499-0035 1.68 µM 0.602178818844385 0.255019637662647 no 907 0.273527556643334 1331 1548538 SGTC_1828 st055811 49 µM 0.601404957134503 0.255275787254179 no 908 0.273785148891403 1305 5877589 SGTC_2616 abietic acid 100 µM 0.60047192265783 0.25558480206642 no 909 0.274095883777392 1347 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1408 3909-7976 48.8 µM 0.600240600343152 0.255661444692097 no 910 0.27417294958373 1360 24152374 SGTC_2636 apigenin dimethyl ether 100 µM 0.59744026254482 0.25659021492214 no 911 0.275106739661849 1352 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2130 NSC 7 2.4545 µM 0.597355524278496 0.256618346890681 no 912 0.275135020560892 1358 21448 SGTC_1896 st058441 89 µM 0.596790974524608 0.25680581083107 no 913 0.275323472261406 1276 688759 SGTC_3194 9111903 49.47 µM 0.596783431554173 0.256808316026264 no 914 0.275325990601635 1395 17087251 SGTC_251 melphalan 456.522 µM 0.594085597565936 0.257705144378816 no 915 0.276227431646636 1432 460612 A DNA alkylator. SGTC_3027 9089541 49.47 µM 0.593819358639317 0.257793737003781 no 916 0.276316469875718 1334 9943819 SGTC_399 oxolinic acid 75 µM 0.593494519456172 0.257901850625744 no 917 0.276425124842808 1321 4628 A DNA gyrase inhibitor. SGTC_1212 0520-0165 585 µM 0.593326188681374 0.257957884060843 no 918 0.276481437790368 1534 5403258 SGTC_3022 9087993 49.47 µM 0.592970145761533 0.258076423345372 no 919 0.27660056600824 1398 17173644 SGTC_1309 pyrazolanthrone 13.4 µM 0.59199830808098 0.258400126217781 no 920 0.276925860680976 1402 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.591814342385375 0.258461425783377 no 921 0.276987458977742 1347 2724278 An inhibitor of dopamine biosynthesis. SGTC_465 cgp-37157 41 µM 0.589460526645202 0.259246409543332 no 922 0.277776192116537 1308 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2669 eugenol 100 µM 0.588922756348325 0.259425925542391 no 923 0.277956545753852 1356 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_66 0109-0187 42.4 µM 0.583601964567574 0.261205541968158 no 924 0.279744069067711 1347 759417 SGTC_1928 4'-methoxychalcone 40.3 µM 0.58329055158672 0.261309892564509 no 925 0.279848860984611 1485 641818 SGTC_2754 granisetron 64.02 µM 0.583173912088664 0.261348982513877 no 926 0.279888115619091 1410 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1667 st014849 34.6 µM 0.582140546962331 0.261695430212466 no 927 0.280236007791582 1380 5348460 SGTC_59 0330-0160 1.33 µM 0.577917690427041 0.26311363713182 no 928 0.281659845571115 1363 4293482 SGTC_2349 9023730 187.07 µM 0.577135544520478 0.2633767439149 no 929 0.281923947271392 1450 4126287 SGTC_734 2023-0417 80 µM 0.576838335438001 0.263476757560882 no 930 0.282024335039919 1393 3935732 SGTC_2791 5663188 71.43 µM 0.575739825111621 0.263846584754174 no 931 0.282395526195255 1422 54690634 SGTC_1690 st023502 41.2 µM 0.575245409940622 0.264013122108215 no 932 0.282562667764765 1411 24207482 SGTC_2523 spermine 47.74 µM 0.575044451176065 0.264080827776155 no 933 0.28263061730373 1363 1103 A DNA binding polyamine. SGTC_279 1273-0055 2.93 µM 0.573948416425037 0.264450252024057 no 934 0.283001354160937 1416 2847562 SGTC_1051 3253-3903 78 µM 0.573593538639405 0.264569921779065 no 935 0.283121442587606 1344 5509239 SGTC_2571 chrysanthemic acid 100 µM 0.572567030060248 0.26491622986834 no 936 0.283468944276548 1315 2743 An insecticide. SGTC_932 2857-0803 154 µM 0.57207009808091 0.265083960054184 no 937 0.283637242971137 1500 674898 SGTC_2060 5238662 140 µM 0.571984329794773 0.265112915008429 no 938 0.283666295432627 1368 790130 SGTC_1842 st055362 61.2 µM 0.570074661756303 0.265758025402551 no 939 0.284313529968277 1420 676032 SGTC_2156 5649887 115 µM 0.569068233758179 0.266098329624347 no 940 0.28465491751304 1453 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1714 st033236 13.627 µM 0.566906843389225 0.266829907188372 no 941 0.285388737240756 1469 2916566 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.566774464926792 0.266874747053551 no 942 0.285433710688367 1379 756377 SGTC_3106 9121286 49.47 µM 0.566696379131513 0.266901198432132 no 943 0.285460240660268 1410 15943471 SGTC_3042 9091578 49.47 µM 0.566037463783139 0.267124457178373 no 944 0.285684156615419 1347 25236497 SGTC_1225 1216-0074 20.6 µM 0.56140685327104 0.268696090820474 no 945 0.287260106577114 1370 4241466 SGTC_2957 9076800 11.52 µM 0.561184986262431 0.268771509161979 no 946 0.287335718429815 1351 16459615 SGTC_2849 9019321 12.99 µM 0.558609098643158 0.269647897689292 no 947 0.288214264535153 1392 16489627 SGTC_1849 st056239 19.2 µM 0.556377896067311 0.270408170088271 no 948 0.28897627311466 1311 5393181 SGTC_2967 9089538 49.85 µM 0.554094370635879 0.27118737899527 no 949 0.289757131262315 1478 728216 SGTC_2541 muurolladie-3-one 83.07 µM 0.553289247610319 0.271462378355327 no 950 0.290032681298279 1420 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_177 1327-0068 8.361 µM 0.552108631791025 0.271865882798012 no 951 0.290436964177719 1391 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2208 7283366 200 µM 0.548765311496556 0.273010161148903 no 952 0.291583259319124 1462 898663 SGTC_2158 5657123 3.6195 µM 0.548232935131277 0.273192591384436 no 953 0.291765985089636 1412 2858827 SGTC_1505 k297-0037 20.6 µM 0.547980966089054 0.273278955060321 no 954 0.291852486185425 1388 4089396 SGTC_3248 9135562 49.47 µM 0.546262652002409 0.273868276315202 no 955 0.29244270252714 1436 17650701 SGTC_1762 st045503 25.4615 µM 0.546005741885135 0.273956441408295 no 956 0.292530995142232 1415 4645554 SGTC_873 0591-4978 488 µM 0.545836798544076 0.274014426160394 no 957 0.292589062858305 1561 3305145 SGTC_3285 9112818 20.8695 µM 0.54289764729391 0.275024171493076 no 958 0.293600137964277 1437 17017947 YPR165W RHO1 SGTC_874 0599-0792 117 µM 0.540822435333652 0.275738212779224 no 959 0.294314988703683 1478 765305 SGTC_630 4356-0227 183 µM 0.539757408114154 0.276105022027003 no 960 0.294682171743422 1442 779312 SGTC_1909 st060837 51.5 µM 0.539690647482907 0.276128023234329 no 961 0.294705195440834 1389 678937 SGTC_3234 9132280 49.47 µM 0.538467089217797 0.276549745340269 no 962 0.295127310071083 1404 17612295 SGTC_619 1652-1634 108 µM 0.537314048727388 0.276947450942806 no 963 0.295525351436234 1417 5400454 SGTC_2419 paclitaxel 166.5 µM 0.536740291807399 0.277145454905759 no 964 0.295723510129043 1369 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1168 k815-0004 80.5 µM 0.536583172819758 0.277199688870193 no 965 0.295777785033747 1391 642433 SGTC_2263 7948595 193.29 µM 0.535086296738025 0.277716637247695 no 966 0.296295092583792 1424 2971371 SGTC_2435 5706476 10.6 µM 0.533894018057318 0.278128729052158 no 967 0.29670743048969 1470 5725375 SGTC_2159 5658611 73.75 µM 0.532569844127066 0.278586757597177 no 968 0.297165690789776 1445 793844 SGTC_1072 oxiconazole 14.9 nM 0.532253270003072 0.278696314204206 no 969 0.297275296321366 1454 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2887 9044784 58.44 µM 0.532227481188538 0.278705239846837 no 970 0.297284225839302 1412 6465546 SGTC_1419 3993-2473 62.6 µM 0.532004129671385 0.278782548788304 no 971 0.297361567649421 1471 704026 SGTC_3097 9117246 49.47 µM 0.531986869513325 0.278788523502947 no 972 0.29736754485225 1420 16423892 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.531107279936522 0.279093081572539 no 973 0.297672219873978 1501 6710655 SGTC_2052 5265182 7.135 µM 0.528465661845576 0.28000871364632 no 974 0.298588087029011 1541 1239884 SGTC_398 bronopol 33.3 µM 0.526627992263636 0.280646540525586 no 975 0.299225974604722 1456 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2787 5284540 71.43 µM 0.526404713742691 0.280724084932455 no 976 0.299303520634703 1466 736958 SGTC_506 n9-isopropylolomoucine 153 µM 0.526199788409718 0.280795264414417 no 977 0.299374700509362 1552 6610355 SGTC_91 0417-1751 58.384 µM 0.526088999447133 0.280833749874298 no 978 0.299413185744256 1478 6795624 SGTC_2071 5230951 39.92 µM 0.521847049145693 0.282309217807576 no 979 0.300888414133364 1463 1799272 SGTC_357 1325-0123 420 µM 0.519599380213768 0.283092528218115 no 980 0.301671415082455 1482 1098503 SGTC_2549 cedrol 20.94 µM 0.519380404678669 0.283168896699001 no 981 0.301747746651591 1506 6708665 A sedative which affects the nervous system. SGTC_2034 5197015 53.07 µM 0.519152483129255 0.283248395630215 no 982 0.301827205887441 1539 780676 SGTC_1931 st074438 57.1 µM 0.517827119655371 0.28371089379747 no 983 0.302289447440664 1416 2787313 SGTC_836 0330-0104 1.35 µM 0.515006099284446 0.284696518059719 no 984 0.303274378943529 1474 46494820 SGTC_2662 daunorubicin 22.37 µM 0.513656231896098 0.285168719934482 no 985 0.30374617875754 1419 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_11 0438-0307 1.3 µM 0.51321984033002 0.285321455410333 no 986 0.303898774478892 1544 4011476 SGTC_2773 thioridazine 9.09 µM 0.51265205727149 0.2855202357482 no 987 0.304097365833636 1461 5452 An antipsychotic. SGTC_3062 9077494 49.47 µM 0.510966321678852 0.286110798362327 no 988 0.304687319709422 1491 16459633 SGTC_2627 acetyl isogambogic acid 100 µM 0.510446453029337 0.286293040604338 no 989 0.304869359835187 1400 6857789 A caspase activator and apoptosis inducer. SGTC_610 4215-0184 155 µM 0.508415236242852 0.287005620438436 no 990 0.30558108493525 1498 5605015 SGTC_2100 5377183 190 µM 0.507938805369273 0.28717288073659 no 991 0.30574812975513 1566 2844202 SGTC_1214 0358-0031 63.7 µM 0.507273256290595 0.287406611871652 no 992 0.305981550335888 1664 4301366 SGTC_2740 felodipine 17.08 µM 0.506299424829993 0.287748769349964 no 993 0.306323233364444 1547 3333 L-type calcium channel blocker SGTC_2002 4023503 131 µM 0.505547305519631 0.288013159500159 no 994 0.306587240780085 1566 4736863 YCR052W RSC6 SGTC_203 k066-0004 30.888 µM 0.503630262523435 0.288687569747958 no 995 0.307260611216548 1531 6795412 SGTC_1773 st048542 73.5835 µM 0.5019948318507 0.289263496791013 no 996 0.307835578195805 1397 3237138 SGTC_1264 0783-0040 158 µM 0.50158370812061 0.289408361456123 no 997 0.307980190940211 1415 2855798 SGTC_2141 5621638 7.665 µM 0.501539822609443 0.289423827086085 no 998 0.307995629427841 1567 2856238 SGTC_452 diindolylmethane 8 µM 0.499076932333673 0.290292392329219 no 999 0.308862593805591 1496 3071 Inhibits expression of several cancer promoting factors. SGTC_2519 cryptotanshinone 88.04 µM 0.498626169539095 0.290451490835692 no 1000 0.309021382804856 1540 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.498402014261676 0.290530622517354 no 1001 0.30910035867225 1444 23665772 A membrane-active detergent. SGTC_1422 4031-0024 15.5 µM 0.49827429432236 0.290575714941538 no 1002 0.30914536175086 1446 782427 SGTC_1043 0916-0009 19.3 µM 0.498109491608297 0.290633904538906 no 1003 0.309203435455358 1650 3101130 SGTC_3222 9128301 49.47 µM 0.4976767957273 0.290786709510018 no 1004 0.30935593289361 1475 4911358 SGTC_3209 9113616 49.47 µM 0.497237805981046 0.290941775512452 no 1005 0.309510682076818 1625 16649353 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.495731108235551 0.291474285727905 no 1006 0.310042068029768 1587 23847180 SGTC_1771 st048882 4.1505 µM 0.495692856698836 0.291487810833911 no 1007 0.310055563849891 1422 4580403 SGTC_1897 st060201 15 µM 0.495678050514896 0.291493046132421 no 1008 0.310060787802706 1447 611878 SGTC_118 0083-0097 135.343 µM 0.494528814241302 0.291899536772094 no 1009 0.310466380972225 1523 5207356 SGTC_2522 biochanin a 4.94 µM 0.493018149189038 0.29243426783886 no 1010 0.310999881752915 1535 5280373 A possible chelator. SGTC_1093 fluphenazine 7.97 µM 0.492055280226169 0.292775332629637 no 1011 0.311340132405887 1524 6602611 An atypical antipsychotic. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.49129110492754 0.293046148090055 no 1012 0.311610285116915 1470 3256 An antibiotic and ribosome inhibitor. SGTC_1854 st056233 32.9 µM 0.491008469240155 0.293146340549992 no 1013 0.311710228729439 1551 5393174 SGTC_2743 auranofin 4.32 µM 0.490551013350466 0.293308539255334 no 1014 0.311872020403815 1517 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2515 chrysin 20.77 µM 0.489482358209153 0.293687610952523 no 1015 0.31225012070751 1563 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3336 9143619 71.43 µM 0.489019553160235 0.29385184677684 no 1016 0.312413926922943 1528 45595730 SGTC_2866 9034245 58.44 µM 0.487571272772351 0.294366072946554 no 1017 0.312926773836909 1587 6462273 SGTC_2063 5246145 200 µM 0.486091997720696 0.294891732600303 no 1018 0.31345097016888 1545 711240 SGTC_1420 4'-methoxyflavone 42 µM 0.484782482367546 0.295357428906749 no 1019 0.313915325074886 1549 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2485 5633444 17.78 µM 0.48377940286711 0.295714377692393 no 1020 0.314271217129139 1449 5724239 SGTC_1251 0490-5699 265 µM 0.483181301949968 0.295927307954569 no 1021 0.314483505231874 1603 3883818 SGTC_2078 5212016 200 µM 0.48195052630462 0.296365698469203 no 1022 0.314920545939505 1534 1899708 SGTC_882 0843-0131 351 µM 0.480199446444964 0.296989928984506 no 1023 0.31554279021195 1508 5425421 SGTC_925 2064-1272 59.6 µM 0.479762144048151 0.297145913737232 no 1024 0.315698266871049 1483 6815817 SGTC_1744 st037937 38.9 µM 0.477924030519915 0.297801973784554 no 1025 0.316352138519138 1573 1016152 SGTC_2928 9011484 9.79 µM 0.477873649195223 0.297819965201296 no 1026 0.316370068753899 1521 2994751 SGTC_2348 9022543 33.42 µM 0.477599998018345 0.29791769602855 no 1027 0.316467466147089 1543 3162678 YDL140C RPO21 SGTC_683 panaxydol 45 µM 0.477461266224354 0.297967247802336 no 1028 0.316516848159833 1556 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2038 4100038 30.985 µM 0.476206247321494 0.298415682009833 no 1029 0.316963724589985 1545 3596803 SGTC_247 mechlorethamine 29.705 µM 0.475113049473018 0.298806545593709 no 1030 0.317353198883192 1515 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2438 5259590 200 µM 0.474840839635921 0.298903908069766 no 1031 0.317450210733995 1615 1201127 SGTC_355 1311-2252 105 µM 0.47440389523458 0.299060221999378 no 1032 0.317605957940812 1483 5338538 SGTC_111 0083-0039 52.457 µM 0.473984869340991 0.29921016055589 no 1033 0.317755348491394 1475 759313 SGTC_1824 st053723 68.6 µM 0.473592279294025 0.299350670610523 no 1034 0.317895341094348 1470 675225 SGTC_2545 solidagenone 89.61 µM 0.472984824235019 0.299568140945474 no 1035 0.318112003113469 1448 6708572 An anti ulcer agent SGTC_2057 5236571 38.335 µM 0.472225765815232 0.299839986221179 no 1036 0.318382825257289 1617 54684039 YBR257W POP4 SGTC_259 usnic acid 108.925 µM 0.471389648248773 0.300139558260859 no 1037 0.318681253473103 1566 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2278 7948257 134.34 µM 0.470514483078226 0.300453265546535 no 1038 0.31899374462435 1623 1247028 SGTC_851 0394-0702 453 µM 0.470506069042351 0.300456282318054 no 1039 0.31899674960989 1612 762646 SGTC_2874 9043904 71.43 µM 0.467953591301292 0.301372079518164 no 1040 0.319908888953905 1518 4463428 SGTC_2406 ethylparaben 405.7 µM 0.467783061366598 0.301433308292524 no 1041 0.319969867489808 1354 8434 A possible steroid mimic. SGTC_888 0916-0002 6.97 µM 0.466987183701328 0.301719142186849 no 1042 0.320254523795324 1573 2802138 YIL048W NEO1 SGTC_2266 7929956 200 µM 0.46622828872203 0.301991807453352 no 1043 0.320526051304969 1507 2967153 SGTC_716 1683-5115 658 µM 0.46570597079363 0.302179536639483 no 1044 0.320712988973067 1539 723597 SGTC_1119 parthenolide 318.541 nM 0.464743404694973 0.30252563500051 no 1045 0.321057610630183 1634 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2279 7948423 32.93 µM 0.463306208139542 0.303042720991888 no 1046 0.321572448248802 1672 1247112 SGTC_2566 crystal violet carbinol 226 nM 0.463068744820096 0.303128195482895 no 1047 0.321657546230024 1436 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3257 9139206 32.98 µM 0.459635695413446 0.304365118133284 no 1048 0.322888866582323 1581 4910041 SGTC_451 chloral hydrate 100 µM 0.459112359735015 0.304553872427314 no 1049 0.323076740727842 1569 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_744 1594-0068 283 µM 0.457295392623745 0.305209611604077 no 1050 0.323729370451547 1547 668392 SGTC_1267 0828-0272 9.49 µM 0.456606168759036 0.305458514696272 no 1051 0.323977072244254 1657 745334 SGTC_1327 1436-0082 2.18 µM 0.453634284310282 0.306532796216594 no 1052 0.325046036517601 1536 15992205 SGTC_1181 1222-0449 220 µM 0.453240118133127 0.306675405260658 no 1053 0.325187923579688 1612 658318 SGTC_2341 7987486 176.74 µM 0.452297891506711 0.307016420776031 no 1054 0.325527197354656 1690 1258686 SGTC_2135 5326629 150.42 µM 0.452248725737196 0.307034219691948 no 1055 0.325544904770634 1509 5020077 SGTC_1170 0310-0127 64.8 µM 0.450752427785671 0.307576124522614 no 1056 0.326083995729367 1592 774975 SGTC_2374 9071832 200 µM 0.449993567258835 0.307851116940625 no 1057 0.326357539467909 1526 17381698 SGTC_323 4013-0906 34.3 µM 0.449565250609398 0.308006376048505 no 1058 0.326511974493187 1638 2910086 SGTC_1138 3761-0006 1.03 µM 0.449037293719318 0.308197800715392 no 1059 0.326702376997227 1572 12061087 SGTC_135 0933-0004 26.348 µM 0.447870336170653 0.308621096962595 no 1060 0.327123388966794 1502 21230617 YGL099W LSG1 SGTC_34 0469-0683 81.75 µM 0.44690182284684 0.308972603821018 no 1061 0.327472973892227 1624 3690923 SGTC_1357 1503-1303 39.5 µM 0.443794852297332 0.310101410493852 no 1062 0.328595455241414 1552 292895 SGTC_2852 9023854 51.95 µM 0.443564219416796 0.310185274278739 no 1063 0.328678839778397 1619 19798528 SGTC_3095 9117207 49.47 µM 0.443466907590572 0.31022066221289 no 1064 0.328714025098908 1664 17015229 SGTC_2093 5331342 194.4 µM 0.442953699199336 0.310407322089024 no 1065 0.328899612466386 1630 33839 SGTC_2735 sertaconazole 140 nM 0.441060029613692 0.311096494088745 no 1066 0.329584769540882 1634 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_685 1278-0033 54.9 µM 0.440806884152601 0.311188672778152 no 1067 0.329676404658331 1647 3590572 SGTC_3076 9116187 49.47 µM 0.439392219677781 0.31170401709224 no 1068 0.330188681534916 1683 27241210 SGTC_3321 9137793 26.8275 µM 0.438467879565297 0.312040941850227 no 1069 0.330523574754948 1563 4904192 SGTC_2851 9015922 71.43 µM 0.438229616274369 0.312127815049089 no 1070 0.330609920798007 1648 2996893 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.437564499631068 0.312370378567132 no 1071 0.330851005170114 1676 165506 SGTC_1434 4073-0095 163 µM 0.43738195734138 0.3124369647273 no 1072 0.330917183424364 1574 24133745 SGTC_2480 5767542 37.17 µM 0.4367937822585 0.312651555677815 no 1073 0.331130454330154 1635 2867358 SGTC_859 0439-0102 54.6 µM 0.436768764769786 0.312660684516368 no 1074 0.331139526828295 1653 610143 SGTC_3296 9122258 64.045 µM 0.435876012031033 0.312986523643416 no 1075 0.331463345103952 1580 4730474 SGTC_1901 st060216 58.6 µM 0.43434035811738 0.313547352221376 no 1076 0.332020650508613 1552 688792 SGTC_170 4197-0004 226 µM 0.43226685261046 0.314305291116161 no 1077 0.332773737878109 1631 218692 SGTC_1196 1588-0294 184 µM 0.431692282938047 0.314515455247345 no 1078 0.332982538460853 1549 6144269 SGTC_1508 1080-0625 72.9 µM 0.430902086317352 0.314804588856209 no 1079 0.333269783204113 1572 767111 SGTC_2728 chlorpromazine 9.18 µM 0.429733310754959 0.315232452994233 no 1080 0.333694824661734 1609 2726 A thorazine and dopamine antagonist. SGTC_2884 9058502 51.95 µM 0.428194301120946 0.315796230210446 no 1081 0.334254832514596 1545 6471554 SGTC_115 0527-0192 112.043 µM 0.427792881960738 0.315943350522345 no 1082 0.334400959845746 1585 4233931 SGTC_2226 7298446 200 µM 0.426771520224628 0.316317811513893 no 1083 0.334772876002163 1656 3283010 SGTC_232 clozapine 119 µM 0.426485761646368 0.316422612691584 no 1084 0.334876960472865 1602 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.426458835437933 0.316432488565161 no 1085 0.334886768707087 1566 16486 A toxic proline analog. SGTC_2255 7941087 197.44 µM 0.426220475185534 0.316519918973864 no 1086 0.334973599551488 1715 935561 SGTC_891 0929-0073 133 µM 0.424833604169131 0.317028825765499 no 1087 0.335478989441967 1644 5603632 SGTC_2163 5671233 125 µM 0.424597612256051 0.317115456559933 no 1088 0.33556501696917 1691 701023 SGTC_3103 9120822 49.47 µM 0.424595703586755 0.317116157258446 no 1089 0.33556571278282 1665 17141819 SGTC_910 3454-3003 490 µM 0.424490455170609 0.317154796401393 no 1090 0.335604082421107 1614 820824 SGTC_799 1310-0557 151 µM 0.423805418696522 0.317406337930269 no 1091 0.335853862987562 1612 5354492 SGTC_3186 9110464 49.47 µM 0.423214640573906 0.317623336069567 no 1092 0.336069332968905 1634 17018021 SGTC_2850 9015429 58.44 µM 0.422961432802032 0.317716360762142 no 1093 0.33616169999972 1543 6457570 SGTC_1130 3454-2858 15.9 µM 0.422663219224203 0.317825934662808 no 1094 0.336270497272327 1546 715628 YIL048W NEO1 SGTC_1851 st056236 18.9 µM 0.422455957025669 0.317902099304401 no 1095 0.336346120827716 1706 5393171 SGTC_767 0929-0023 86 µM 0.422393482506841 0.31792505893039 no 1096 0.336368917143161 1591 1204563 SGTC_1041 0206-0046 107 µM 0.422302383474887 0.31795853942946 no 1097 0.336402159329969 1598 50494 SGTC_815 1582-0027 36.9 µM 0.42197914077126 0.318077348822754 no 1098 0.336520121443032 1656 3128206 SGTC_2546 rhodinyl acetate 100 µM 0.421121250186131 0.318392761350833 no 1099 0.336833272513114 1720 6708682 SGTC_2955 9076254 12.21 µM 0.420937469415076 0.318460347425562 no 1100 0.336900371717739 1693 16459619 SGTC_2583 asiatic acid 100 µM 0.420414582540897 0.318652674097405 no 1101 0.337091308508893 1611 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2478 5763493 32.33 µM 0.420352748653047 0.318675420883202 no 1102 0.337113890479221 1654 1365576 YLR208W SEC13 SGTC_753 1322-0200 289 µM 0.419880806358177 0.318849056443985 no 1103 0.337286264926096 1606 5403907 SGTC_2404 5161160 200 µM 0.419114853928118 0.319130947951194 no 1104 0.337566097730578 1646 2831543 SGTC_1707 st032323 6.317 µM 0.418720379694733 0.319276166115629 no 1105 0.337710249874979 1604 3132057 YMR211W DML1 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.41768222147971 0.319658476736642 no 1106 0.338089736267894 1605 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1965 Pectolinarigenin 58.4 µM 0.414678350711295 0.320765756528006 no 1107 0.339188691405871 1584 5320438 An anti-inflammatory. SGTC_1873 rapamycin 2 nM 0.409868893902312 0.322541928873422 no 1108 0.340951062377104 1594 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_896 0964-0007 44.5 µM 0.405838580061407 0.324033484800215 no 1109 0.342430604726042 1685 6756758 SGTC_3239 9133757 49.47 µM 0.404588389939549 0.324496736641404 no 1110 0.342890047017649 1669 17036923 SGTC_3039 9090270 49.47 µM 0.404007552011379 0.324712055782937 no 1111 0.343103582880633 1729 17173750 SGTC_856 0433-0016 11.3 µM 0.403346650871164 0.324957125964024 no 1112 0.343346613664566 1619 3911780 SGTC_2496 diffractaic acid 79.83 µM 0.401558216843985 0.325620678722375 no 1113 0.344004592683787 1730 94870 An apoptosis inducer which activates caspases. SGTC_2458 5808907 16.39 µM 0.401032943096906 0.325815673275219 no 1114 0.344197934934 1696 2731747 SGTC_2719 novobiocin 32.65 µM 0.399118548535226 0.326526746737235 no 1115 0.344902927834948 1718 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2086 5274770 176.623 µM 0.398591754609896 0.326722527304323 no 1116 0.345097019040373 1633 689278 SGTC_1491 4138-0063 26.5 µM 0.398390155159311 0.326797463452428 no 1117 0.345171306841612 1706 23883227 SGTC_1751 st044839 27.194 µM 0.397601822797917 0.32709056002801 no 1118 0.345461858335686 1655 5291326 SGTC_886 0866-0150 153 µM 0.396347284284827 0.327557208765332 no 1119 0.345924424719286 1752 271463 SGTC_1174 0739-0097 51.1 µM 0.395672371413102 0.32780836660507 no 1120 0.346173370011547 1642 728447 SGTC_2152 5568786 200 µM 0.394854958444324 0.328112657853957 no 1121 0.346474966260166 1642 5399883 SGTC_1009 4106-0057 9.87 µM 0.392410199859329 0.329023427323168 no 1122 0.347377575398189 1695 2928005 SGTC_1591 genipin 88.4 µM 0.391978226408083 0.329184460322624 no 1123 0.347537150942273 1698 442424 A DNA cross-linking agent. SGTC_2143 5623677 140.463 µM 0.391259049426263 0.329452628647391 no 1124 0.347802882428098 1664 5375313 SGTC_1012 4112-3522 18 µM 0.385242165975916 0.331699644089412 no 1125 0.350029002839415 1768 3112398 SGTC_51 1013-0126 23.419 µM 0.384841080468538 0.33184964680072 no 1126 0.350177580468318 1785 1627850 SGTC_1925 st057770 10.1 µM 0.381550589740796 0.333081279496293 no 1127 0.35139736992688 1546 5989122 SGTC_1289 0976-0073 69.1 µM 0.381177970604455 0.333220864932147 no 1128 0.351535597156235 1679 3391136 SGTC_2444 5485484 36.41 µM 0.381158069820595 0.3332283205391 no 1129 0.351542980126687 1721 6790631 SGTC_1626 st003712 1.76 µM 0.380544235669011 0.333458319018115 no 1130 0.351770733291795 1696 24207035 SGTC_862 0452-0056 10.2 µM 0.379227148578704 0.333952031685362 no 1131 0.352259596475674 1679 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3300 9124615 50.48 µM 0.378296212604954 0.334301168359038 no 1132 0.352605279324894 1731 24824903 SGTC_270 tamoxifen 5.46 µM 0.37753581485094 0.334586453080304 no 1133 0.352887726868317 1791 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2309 7664088 163.95 µM 0.377411969327613 0.334632926281256 no 1134 0.352933736612587 1800 704922 SGTC_2963 9082507 9 µM 0.376033628182337 0.335150321536195 no 1135 0.353445947972285 1713 16459611 SGTC_761 k216-0224 480 µM 0.375388947949013 0.335392426063049 no 1136 0.353685611602024 1843 1340404 SGTC_3341 9147222 25.867 µM 0.374640036198627 0.335673759754491 no 1137 0.353964096732203 1688 1939759 SGTC_1075 aripiprazole 15.2 µM 0.373313400369122 0.336172345430265 no 1138 0.354457602070513 1652 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1578 josamycin 24.2 µM 0.372284410148115 0.336559266435874 no 1139 0.354840552345075 1607 5282165 A P450 substrate. SGTC_1946 st076057 65.1 µM 0.372013478618711 0.3366611709438 no 1140 0.354941406975335 1622 953009 SGTC_980 1473-0395 201 µM 0.370279880432582 0.337313506697096 no 1141 0.355586981614678 1635 768876 SGTC_129 0088-0017 176.636 µM 0.369831438005289 0.337482330865297 no 1142 0.355754044645307 1770 182446 SGTC_2755 lomerizine 42.69 µM 0.369643969335766 0.337552916496845 no 1143 0.355823892558963 1622 3949 A calcium channel blocker. SGTC_3171 9103192 49.47 µM 0.369199177509243 0.337720412209613 no 1144 0.355989634445418 1737 13018434 SGTC_2843 9000894 45.46 µM 0.368733226007772 0.337895910519808 no 1145 0.356163290211628 1631 2242070 SGTC_1653 st012112 65 µM 0.368645032375342 0.337929132179698 no 1146 0.356196162512858 1725 720429 SGTC_205 1486-1330 71.903 µM 0.367699620647735 0.338285338584817 no 1147 0.356548611722869 1700 4118834 SGTC_996 3970-0799 1.8 µM 0.366929847912574 0.338575475767087 no 1148 0.356835673289482 1786 6615648 YGL040C HEM2 SGTC_1172 0370-0043 85 µM 0.365744275389372 0.339022520625041 no 1149 0.357277952364181 1717 376585 SGTC_356 1634-0012 32.5 µM 0.365080709382684 0.339272831058513 no 1150 0.357525580120877 1835 735457 SGTC_300 r073-0011 5.04 µM 0.365012569450371 0.33929853882884 no 1151 0.357551011793758 1707 2735780 SGTC_2826 7992541 19.48 µM 0.362900803026733 0.34009563440306 no 1152 0.35833949342847 1715 2985066 SGTC_2620 irigenin 100 µM 0.35934605301246 0.34143900440994 no 1153 0.359668113263122 1777 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_675 1309-0189 238 µM 0.358736106952567 0.341669710811616 no 1154 0.359896257199936 1667 4246530 SGTC_3223 9129970 49.47 µM 0.358010108472129 0.341944390064497 no 1155 0.360167874401335 1698 17248386 SGTC_1912 st060209 90.8 µM 0.357663998817787 0.342075369034049 no 1156 0.360297388977087 1626 688787 SGTC_2531 methyl deoxycholate 70.07 µM 0.35604933518017 0.342686660351773 no 1157 0.360901809370644 1635 16667744 Haematoxylin. SGTC_41 0478-0632 82.643 µM 0.355721153311871 0.342810956326478 no 1158 0.361024700918365 1848 3750424 SGTC_2968 9090663 33.37 µM 0.354878514143976 0.34313017635713 no 1159 0.361340302717 1700 25236811 SGTC_2114 5491910 81.25 µM 0.354770657283904 0.343171044248528 no 1160 0.361380706208374 1764 2849228 SGTC_3326 9140064 16.379 µM 0.35425997609915 0.343364570635935 no 1161 0.36157202983861 1631 1868434 SGTC_478 N-arachidonylglycine 10 µM 0.353526172142676 0.343642722945322 no 1162 0.361847005666957 1776 5283389 SGTC_1177 0983-0204 23.6 µM 0.352127634773569 0.34417308038463 no 1163 0.362371272205677 1830 766818 SGTC_2847 9005661 71.43 µM 0.351758830210569 0.344312990667712 no 1164 0.362509568204422 1716 2991449 SGTC_940 3232-1287 54.8 µM 0.351190986447153 0.344528450433909 no 1165 0.362722535894814 1787 1585493 YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM 0.350981634471853 0.34460789862177 no 1166 0.362801063293702 1725 5322280 SGTC_2603 homopterocarpin 100 µM 0.350028495140738 0.344969697562339 no 1167 0.363158656351206 1692 101795 A weak amylase inhibitor. SGTC_3010 9080089 71.4286 µM 0.349854298043192 0.345035835784435 no 1168 0.36322402347108 1782 17027233 SGTC_1322 1348-1070 12 µM 0.349284060979451 0.345252373448351 no 1169 0.363438031669559 1765 6758089 SGTC_369 0957-0393 4.5 µM 0.348724020351477 0.345465088511832 no 1170 0.363648254670423 1640 6997992 SGTC_2555 cholic acid 100 µM 0.348648283441318 0.345493858711912 no 1171 0.363676687261963 1744 6708657 Influences liver metabolism. SGTC_2983 9022671 12.99 µM 0.34780091550109 0.345815809421418 no 1172 0.363994851034771 1853 6405161 SGTC_1298 1079-1278 263 µM 0.345757266430915 0.346592736073016 no 1173 0.364762571503234 1717 2840950 SGTC_125 0133-0007 11.75 µM 0.344920484684764 0.346911038866777 no 1174 0.365077075017688 1877 26541 SGTC_1117 retinoic acid 1.10837 µM 0.344274431514837 0.347156864496857 no 1175 0.365319955518017 1849 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_939 1165-0479 45.3 µM 0.343888847932816 0.347303611140775 no 1176 0.365464939513163 1809 1377347 SGTC_1574 spiramycin 23.7 µM 0.343510333900461 0.347447689501306 no 1177 0.365607283974317 1651 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1911 st060208 74.3 µM 0.342862369809803 0.347694383044244 no 1178 0.365851001115278 1796 688783 SGTC_2805 7950783 58.44 µM 0.342253632879604 0.347926200751354 no 1179 0.366080013175133 1743 1178958 YDL195W SEC31 SGTC_1972 st070201 17.4 µM 0.341199981349963 0.348327584074211 no 1180 0.366476518661506 1827 2829099 SGTC_2816 7982706 58.44 µM 0.339310460548491 0.34904781300392 no 1181 0.367187931608934 1697 2981853 SGTC_2950 9072895 21.46 µM 0.339108675959767 0.349124759466865 no 1182 0.367263931403382 1661 17332245 SGTC_2439 5492030 7.2 µM 0.338257996218082 0.349449217110776 no 1183 0.367584387077665 1838 5722370 SGTC_1891 st059073 26.2 µM 0.337654410519393 0.349679497397771 no 1184 0.367811817029943 1854 688754 SGTC_2716 st080858 38.6235 µM 0.336618535134919 0.350074833938495 no 1185 0.368202240924052 1799 5296050 SGTC_1994 st072947 40.9 µM 0.335425010448379 0.350530538052221 no 1186 0.368652252014531 1779 5286565 YDL195W SEC31 SGTC_2694 st077685 81.9 µM 0.333895173595085 0.351114965408652 no 1187 0.369229330954663 1680 2838096 SGTC_351 caspofungin 25 nM 0.333256434324579 0.351359080539856 no 1188 0.369470360949808 1786 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1765 st044815 90.4 µM 0.332898525595607 0.351495893899794 no 1189 0.369605441215862 1660 645695 SGTC_2375 9072683 200 µM 0.332877109844275 0.351504080845437 no 1190 0.36961352436072 1887 16798029 SGTC_654 1124-0271 80.9 µM 0.331701595437725 0.351953569320626 no 1191 0.370057297920668 1670 5403748 SGTC_2492 derrusnin 100 µM 0.329291789476109 0.352875667703236 no 1192 0.3709675747204 1707 1715307 Part of coumarin class of compounds. SGTC_2997 9067075 71.4286 µM 0.329132216111807 0.35293675812133 no 1193 0.371027877305605 1785 27209819 SGTC_844 0330-0132 15.3 µM 0.32823322709345 0.353280994228178 no 1194 0.371367663333581 1813 2828079 SGTC_2598 perillyl alcohol 100 µM 0.326157153712754 0.354076411662717 no 1195 0.372152728360303 1796 10819 An apoptosis inducer. SGTC_423 5-fluorouracil 457 µM 0.323525338463556 0.355085669121672 no 1196 0.373148710561335 1633 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1347 1493-0251 600 nM 0.323485465242172 0.355100967682571 no 1197 0.373163806693297 1854 3986378 SGTC_453 enantio-paf c16 10 µM 0.323432096203342 0.355121444685377 no 1198 0.373184012690587 1748 13871343 A lipid and platelet activating factor SGTC_2794 7785382 27.27 µM 0.322120540884033 0.355624802678772 no 1199 0.373680688791532 1924 2205081 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.32199587938127 0.355672659275284 no 1200 0.373727908096242 1731 6708784 An antioxidant flavonoid SGTC_1011 4112-3381 17.4 µM 0.321817369851741 0.355741191678205 no 1201 0.373795527265694 1785 2877139 SGTC_276 colchicine 750 µM 0.321291199993457 0.355943223055355 no 1202 0.373994862292809 1764 2833 A microtubule depolymerizer. SGTC_1367 1812-0510 76.9 µM 0.320938623684547 0.356078623041185 no 1203 0.374128451723563 1776 1142582 YDR527W RBA50 SGTC_1371 2421-0008 32.7 µM 0.320767884457437 0.356144198602406 no 1204 0.374193149411468 1739 2827552 SGTC_3202 9113761 49.47 µM 0.320648180043746 0.356190175836146 no 1205 0.374238510748278 1889 4798415 SGTC_3019 9081971 49.47 µM 0.318000261320497 0.357207747769187 no 1206 0.37524236934301 1865 16451803 SGTC_1831 st055328 12 µM 0.316344574699562 0.357844530567552 no 1207 0.375870490624468 1855 1103068 SGTC_3118 9124250 49.47 µM 0.316007088352393 0.357974377602158 no 1208 0.375998563948123 1740 1504786 SGTC_1073 triclabendazole 3.09 µM 0.315843802641949 0.358037207273694 no 1209 0.376060534451103 1766 50248 An antihelmetic and likely tubulin inhibitor. SGTC_202 3594-0513 34.79 µM 0.314661650468998 0.358492194698171 no 1210 0.376509282326435 1792 708429 SGTC_218 alverine citrate 93.75 µM 0.314620594773509 0.358507999852667 no 1211 0.376524870172624 1828 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_658 3253-0951 102 µM 0.313590113404269 0.358904782165245 no 1212 0.376916184702564 1779 1184878 SGTC_1450 4112-4260 37.6 µM 0.31343462503481 0.358964665510416 no 1213 0.37697524077645 1875 1633175 SGTC_897 1000-0139 31.4 µM 0.310954273479278 0.35992039279972 no 1214 0.377917691969805 1890 6151020 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.309905876976634 0.360324624065215 no 1215 0.37831626675412 1873 77254 SGTC_3164 9100705 49.47 µM 0.309340446179967 0.360542702634632 no 1216 0.378531283543721 1851 17174235 SGTC_1507 4075-3230 155 µM 0.309016956151984 0.360667488517948 no 1217 0.378654314255848 1867 659771 SGTC_3111 9122088 49.47 µM 0.308726081053747 0.360779705901554 no 1218 0.378764951260653 1865 16876704 SGTC_1641 st009299 47.1 µM 0.308674215361755 0.360799716547622 no 1219 0.378784679895126 1835 4046054 SGTC_2186 6124449 200 µM 0.308137979413884 0.361006627618729 no 1220 0.378988671442993 1837 3834182 YLR033W RSC58 SGTC_1272 0839-0021 27 µM 0.307877547716581 0.361107132020945 no 1221 0.37908775541586 1795 5027250 SGTC_291 SEC14.278 35.5 µM 0.307847796262538 0.361118614152763 no 1222 0.379099075174609 1854 1068044 SGTC_2173 5763948 167 µM 0.305086203661182 0.362184953433536 no 1223 0.380150249254314 1815 2867177 SGTC_3056 9094900 49.47 µM 0.303433423473806 0.362823657353709 no 1224 0.380779788664726 1680 25236784 SGTC_416 estradiol valerate 100 µM 0.303309446686906 0.362871582625312 no 1225 0.380827023832639 1796 13791 A steroid. SGTC_701 4424-0219 185 µM 0.301448924374693 0.363591055804317 no 1226 0.381536095986705 1908 2911779 SGTC_1495 4469-0029 237 µM 0.298461424382555 0.364747342969816 no 1227 0.382675507017992 1765 793680 SGTC_946 3434-1334 87.4 µM 0.298156720992684 0.364865345272762 no 1228 0.382791775977423 1852 4047976 SGTC_802 4112-3352 742 µM 0.297670270538171 0.365053759183093 no 1229 0.382977418014597 1893 704594 SGTC_1473 k844-0725 134 µM 0.296314478536807 0.365579061736409 no 1230 0.383494964954993 1825 54682906 SGTC_1475 4092-1048 11.7 µM 0.293308663880081 0.366744564859167 no 1231 0.384643115956262 1794 2881759 SGTC_3334 9142812 21.919 µM 0.291651135405112 0.367387797409474 no 1232 0.385276686923567 1857 45283678 SGTC_3110 9122132 49.47 µM 0.290813564492612 0.367712972974945 no 1233 0.385596955271278 1903 918317 SGTC_2575 plumbagin 510 nM 0.290367123816573 0.367886336290002 no 1234 0.38576769607045 1712 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_791 1348-1292 225 µM 0.290267969005435 0.367924844067241 no 1235 0.38580562073595 1881 5437054 SGTC_1270 0831-1170 17.3 µM 0.289908216545878 0.368064568728266 no 1236 0.38594322777687 1795 6764716 SGTC_2810 7959871 45.46 µM 0.289773229750168 0.368117000905972 no 1237 0.385994864577449 1855 2974535 SGTC_2324 6149169 200 µM 0.284056704721927 0.370339682924687 no 1238 0.388183462730917 1888 2888231 SGTC_3096 9117468 49.47 µM 0.283732929648343 0.370465702612346 no 1239 0.388307528570186 1872 41316311 SGTC_1560 lithocholic acid 53.1 µM 0.282519863997988 0.370937975365421 no 1240 0.388772458712116 1918 9903 A bile acid which acts as a detergent. SGTC_828 2074-0507 139 µM 0.282453678653874 0.370963748355729 no 1241 0.388797830075928 1907 X828 SGTC_63 0099-0242 26.702 µM 0.281402537953743 0.371373146700229 no 1242 0.389200835866229 1945 3898502 YLR359W ADE13 SGTC_1127 asiatic acid 681.4 nM 0.281314556079943 0.371407420494225 no 1243 0.38923457339949 1729 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_937 3122-0005 46.7 µM 0.280605173602546 0.371683801339574 no 1244 0.38950662372409 1945 759535 SGTC_3047 9092122 49.47 µM 0.280422169292793 0.371755111959867 no 1245 0.389576815223221 1769 17173831 SGTC_1985 st071382 65.5 µM 0.279669425075854 0.372048477297684 no 1246 0.389865568931862 1805 6123237 SGTC_2844 9010103 25.97 µM 0.27948208239893 0.372121501496661 no 1247 0.389937443292328 1814 2480525 SGTC_330 1488-0319 80.1 µM 0.27919704055552 0.372232616621856 no 1248 0.390046807334833 1839 6846614 SGTC_2287 7945887 168.79 µM 0.279191085455886 0.372234938154657 no 1249 0.390049092263345 1951 1245853 SGTC_1876 myriocin 605 nM 0.27879682595719 0.372388646389687 no 1250 0.390200375219603 1933 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1002 4049-0206 172 µM 0.276356704695517 0.373340417271159 no 1251 0.391137053452577 1778 4662749 SGTC_1036 k216-0215 33.5 µM 0.276264435532201 0.373376422127083 no 1252 0.39117248482643 1755 622330 SGTC_883 0850-0245 24.6 µM 0.276150942378112 0.373420710428958 no 1253 0.391216067454896 1910 6823229 YPR165W RHO1 SGTC_2949 9072542 2.23 µM 0.275931828802013 0.373506219595397 no 1254 0.391300213359309 1768 16457352 SGTC_429 1112-0049 25.5 µM 0.273488997227658 0.374459956562258 no 1255 0.392238674508205 1758 2836170 SGTC_1333 1482-0047 286 µM 0.27299154343052 0.374654268218766 no 1256 0.392429858068806 1935 3811116 SGTC_1242 0402-0103 60.1 µM 0.271742274024246 0.375142388677279 no 1257 0.392910096986158 1831 432868 SGTC_2157 5649910 96.377 µM 0.271738817330829 0.375143739570747 no 1258 0.39291142602031 1753 2858091 SGTC_43 0570-0105 72.5 µM 0.271657779293855 0.375175410088859 no 1259 0.392942583991848 1824 1114046 YDL195W SEC31 SGTC_3225 9130819 49.47 µM 0.270746830877319 0.375531476171835 no 1260 0.393292877837892 1909 4547121 SGTC_1142 3253-1408 9.78 µM 0.270586036036798 0.375594337719918 no 1261 0.393354718466952 1939 256655 SGTC_2857 9024691 58.44 µM 0.267964669474851 0.376619606190302 no 1262 0.394363257078467 1822 16478292 SGTC_264 promethazine 12.5 mM 0.267932263521909 0.376632286265878 no 1263 0.394375729318971 1968 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3134 9127454 49.47 µM 0.267861458297935 0.376659991996375 no 1264 0.394402980854943 1877 24262820 SGTC_1767 st044992 70.3 µM 0.267648957220751 0.376743146420485 no 1265 0.394484771436482 1780 9600693 SGTC_1852 st056254 31.4 µM 0.264749718899156 0.377878225677098 no 1266 0.395601136750113 1873 442583 SGTC_2749 bexarotene 57.39 µM 0.261172593651208 0.379280157439853 no 1267 0.396979705964451 1773 82146 An retinoic acid receptor inhibitor. SGTC_2357 9067248 200 µM 0.26097312674353 0.379358378607685 no 1268 0.397056615532624 1862 9150235 SGTC_1524 corynanthine 62.1 µM 0.26048348571301 0.379550412813796 no 1269 0.397245426126639 1879 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.258337571296243 0.380392377188824 no 1270 0.398073196193448 1977 6708630 An antioxidant. SGTC_1839 st053978 48 µM 0.257987403242885 0.380529821961201 no 1271 0.398208314497204 1963 3788398 SGTC_1315 1237-0019 3.69 µM 0.257492051186592 0.380724278790233 no 1272 0.39839947536405 1949 825140 SGTC_308 4092-1169 104 µM 0.257115912864637 0.380871956864867 no 1273 0.398544646855753 1881 2268590 YDL196W YDL196W SGTC_2035 5154463 94.595 µM 0.256240407387845 0.381215761855528 no 1274 0.398882604645521 1954 2769623 SGTC_6 0844-0013 19.835 µM 0.254571493081717 0.381871392594688 no 1275 0.399527039563413 1942 1584900 SGTC_1097 itavastatin 7.23 µM 0.252822936815743 0.382558674189071 no 1276 0.400202521181497 1864 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1339 1486-1321 22.7 µM 0.251979502934903 0.382890323888332 no 1277 0.40052845350506 1839 3469382 SGTC_3278 9139605 49.47 µM 0.251600986625735 0.383039189593918 no 1278 0.400674747967768 1937 7958859 SGTC_2512 diallyl trisulfide 49.23 µM 0.25073062454428 0.383381557558674 no 1279 0.401011190925031 1953 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1257 0669-0121 16 µM 0.24543198607004 0.38546780032837 no 1280 0.40306098246028 1949 4307855 SGTC_73 0327-0325 16.231 µM 0.243988577481985 0.386036693922764 no 1281 0.403619833239233 2024 53298 SGTC_1314 1222-0010 41.1 µM 0.2433464208483 0.386289867302615 no 1282 0.40386852314878 1892 3526027 SGTC_2389 9091542 195.52 µM 0.242458867563927 0.386639869200349 no 1283 0.404212312509695 1857 3626624 YOL127W RPL25 SGTC_2989 9073649 71.4286 µM 0.240714251363272 0.387328117865422 no 1284 0.404888296357952 2043 21367202 SGTC_957 1187-1561 14.1 µM 0.240168952216559 0.387543310399439 no 1285 0.405099640943932 1962 1538454 SGTC_2674 ligustilide 100 µM 0.23868184965573 0.388130344195227 no 1286 0.405676145956414 1905 5319022 A signalling regulator. SGTC_930 2810-3379 265 µM 0.238391942764172 0.388244814776932 no 1287 0.405788558029771 2012 1015764 SGTC_1607 st000305 50.6 µM 0.238167584538131 0.388333409941713 no 1288 0.405875558788513 1982 5457690 SGTC_911 3456-4043 236 µM 0.237076906382464 0.388764182495185 no 1289 0.406298563872215 1937 914281 SGTC_2293 7624732 200 µM 0.235749042040146 0.38928881837044 no 1290 0.406813706094954 1867 894453 SGTC_604 1000-0114 314 µM 0.23549257992491 0.389390169199624 no 1291 0.406913218651808 1992 1572745 SGTC_1461 k072-0203 53.8 µM 0.233378948993208 0.390225737376558 no 1292 0.40773357908415 1990 5418714 SGTC_1292 0kpi-0043 232 µM 0.231661106267292 0.390905215100795 no 1293 0.408400621157456 1876 3333905 SGTC_1351 1496-0003 46.5 µM 0.231502040872743 0.390968148917728 no 1294 0.408462400055918 1975 3891978 SGTC_1863 st057641 20.1 µM 0.229367999140398 0.391812752586265 no 1295 0.409291453089037 2063 3921635 SGTC_1273 0849-0096 14.1 µM 0.228813828179314 0.392032164053295 no 1296 0.409506809281078 1867 5286025 SGTC_2625 euphol 100 µM 0.2285222885392 0.392147606372846 no 1297 0.409620115369775 2024 6708538 A triterpene alcohol. SGTC_1772 st048439 82.2 µM 0.227848178176235 0.392414573356118 no 1298 0.409882135422844 1877 2927068 YDL195W SEC31 SGTC_432 NS 1619 61.3 µM 0.227315713582927 0.392625480365932 no 1299 0.410089127618102 1900 4552 A K+/calcium channel activator. SGTC_1139 k015-0024 46.9 µM 0.226067558620674 0.393119992851863 no 1300 0.410574437959742 2034 2766652 SGTC_2640 pentamidine 10.38 µM 0.225838683374007 0.393210690771747 no 1301 0.410663444614456 2039 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2150 5556613 200 µM 0.223961138398116 0.393954936423735 no 1302 0.411393771104605 1933 743190 SGTC_699 0375-0592 111 µM 0.222779571616942 0.394423500023367 no 1303 0.411853533981321 2078 762578 SGTC_2592 piperlongumine 83.33 µM 0.22275805774504 0.394432033009811 no 1304 0.411861906430253 1843 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2471 5466956 24.79 µM 0.222518289730713 0.394527134949782 no 1305 0.411955218497277 1948 724419 SGTC_895 0964-0006 13.7 µM 0.222193022502413 0.394656159472643 no 1306 0.412081812802859 2014 6738897 SGTC_225 nsc-122657 1.016 µM 0.221671911219386 0.394862894003718 no 1307 0.412284648861553 1969 275685 SGTC_1682 st012968 530 nM 0.219342786608601 0.3957872621269 no 1308 0.413191517200663 1828 24207270 SGTC_1513 0337-0559 19 µM 0.218331135922855 0.396188942585352 no 1309 0.413585558307709 1856 775073 SGTC_800 3448-7362 155 µM 0.218140408945839 0.396264683953436 no 1310 0.413659856825673 2036 15991913 SGTC_2558 carylophyllene oxide 100 µM 0.216300863537537 0.396995403586528 no 1311 0.414376617996063 2041 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1967 st070177 51.4 µM 0.212330054624406 0.398573951734427 no 1312 0.415924774874045 2000 5729214 SGTC_94 0334-0113 514.748 µM 0.211069740767894 0.399075323079257 no 1313 0.41641642583788 1833 6795178 SGTC_3136 9095672 49.47 µM 0.210688408648615 0.39922705544884 no 1314 0.416565210072773 2075 17217380 SGTC_339 3091-4833 71.4 µM 0.210241291540907 0.39940498311122 no 1315 0.416739676840119 1975 3240077 SGTC_2326 6164455 177.58 µM 0.208420529103499 0.400129760416382 no 1316 0.417450314183217 1904 2888790 SGTC_745 0469-0705 296 µM 0.207913228657693 0.400331759119651 no 1317 0.41764835995115 2043 3486736 SGTC_2686 alizarin 95.37 µM 0.206821326374154 0.400766627063012 no 1318 0.418074700097691 1889 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1785 bathophenanthroline 24 µM 0.206818675042782 0.400767683149015 no 1319 0.418075735444165 1872 72812 An iron chelator. SGTC_826 1683-5028 118 µM 0.206587027936123 0.400859956295592 no 1320 0.418166195967735 1933 722377 SGTC_3196 9111891 49.47 µM 0.206555234070695 0.400872621336292 no 1321 0.418178612129732 2026 18891510 SGTC_2813 7971799 71.43 µM 0.206483001954216 0.400901395283529 no 1322 0.418206820568129 1933 2234054 SGTC_1305 1181-0477 144 µM 0.204480983711656 0.401699120534381 no 1323 0.418988825427187 2060 6252086 SGTC_720 r052-1644 49.9 µM 0.203370849630453 0.40214164198257 no 1324 0.419422591162822 1946 1422863 YOR257W CDC31 SGTC_1427 4048-4900 550 nM 0.202333642347134 0.402555206749315 no 1325 0.419827950522975 2068 24132586 SGTC_2657 nystatin 74.44 µM 0.201162598112119 0.403022267287675 no 1326 0.420285718016098 2009 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_501 nsc-95397 161 µM 0.200831551190354 0.403154327518831 no 1327 0.420415145618931 2031 262093 SGTC_2933 9026794 32.47 µM 0.200365038915209 0.403340445925333 no 1328 0.420597549973908 1973 17586027 SGTC_2212 7123476 200 µM 0.200061011843064 0.403461751486187 no 1329 0.420716432470998 2033 1085715 SGTC_1951 sophoraflavanone G 9.2 µM 0.199986200354699 0.403491602389148 no 1330 0.420745686818818 1843 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_483 fpl-64176 144 µM 0.199592630276908 0.403648651993223 no 1331 0.420899595999986 2045 3423 SGTC_1741 st038134 10.228 µM 0.19881410448677 0.403959359478841 no 1332 0.421204081227015 2015 1272587 SGTC_1145 3546-0597 10.2 µM 0.198127796784292 0.404233313250498 no 1333 0.421472538605463 1961 875334 SGTC_2417 cerulenin 830 nM 0.197980505313537 0.404292113783164 no 1334 0.421530158169327 2085 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1228 0124-0032 52.5 µM 0.195988704840754 0.405087476356712 no 1335 0.422309503392327 2030 X1228 SGTC_447 ml7 120 µM 0.195843261320525 0.40514557003451 no 1336 0.422366424017918 2082 4216 Selective myosin light chain kinase inhibitor. SGTC_2311 7694451 200 µM 0.193609328822442 0.40603811884164 no 1337 0.423240896533465 1993 2163142 SGTC_558 k064-0027 21.3 µM 0.192205549336478 0.406599237327885 no 1338 0.4237905996029 2004 5088526 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.192174508337009 0.406611647202682 no 1339 0.423802756563047 1969 364106 SGTC_289 k017-0060 526 µM 0.191404706733243 0.406919436001438 no 1340 0.424104266399423 1978 5512909 SGTC_2670 beta-carotene 100 µM 0.191094200112548 0.40704360175408 no 1341 0.424225895774297 2047 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2315 7733312 200 µM 0.19092217459265 0.407112395544018 no 1342 0.42429328345613 1938 726316 SGTC_1632 st005650 90 µM 0.190522565215638 0.407272212213089 no 1343 0.424449831266624 1971 2759605 SGTC_628 1636-0253 16 µM 0.190460528895529 0.407297023921894 no 1344 0.424474135194387 2063 4456143 SGTC_711 k292-0785 179 µM 0.190328181173896 0.407349958239129 no 1345 0.424525985932737 2007 4146315 SGTC_1144 3486-0183 12.5 µM 0.1902183641952 0.40739388235597 no 1346 0.424569010645121 1972 6744069 SGTC_1428 4049-0204 61.7 µM 0.18984574912328 0.407542927984754 no 1347 0.424715002565158 2058 X1428 SGTC_2356 9061756 188.97 µM 0.189207960790529 0.407798073684504 no 1348 0.424964914275668 2072 20104043 SGTC_3162 9099653 49.47 µM 0.188871254781828 0.407932787900023 no 1349 0.425096861713818 2076 25237511 SGTC_208 k072-0098 12.366 µM 0.188686327485459 0.408006780922434 no 1350 0.425169334092435 2090 5948901 SGTC_2693 st077581 40.7 µM 0.188482813588532 0.408088214598715 no 1351 0.425249093419381 2125 25238761 SGTC_2765 myclobutanil 7.74 µM 0.186991173732481 0.408685197598235 no 1352 0.425833776615965 1968 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1711 st032263 62.8 µM 0.186953234468126 0.408700384392141 no 1353 0.425848649932023 2015 3958979 SGTC_1989 st071868 50.2 µM 0.186098773852009 0.40904245463422 no 1354 0.426183651721602 2085 16414057 SGTC_387 norethindrone acetate 66.7 µM 0.182393069264941 0.410526775388353 no 1355 0.427637132253314 1953 541197 SGTC_601 0986-0029 62.9 µM 0.182195632611068 0.410605894853077 no 1356 0.427714600152232 1986 24747981 SGTC_253 dyclonine 31.25 µM 0.18150528096542 0.410882570404358 no 1357 0.4279854941934 2013 3180 An oral anasthetic. SGTC_998 3996-0085 177 µM 0.180638036241178 0.411230203073454 no 1358 0.428325849185122 2064 715391 SGTC_121 0557-0495 61.343 µM 0.178909863016519 0.411923144193579 no 1359 0.429004239087558 2035 3104427 SGTC_1968 st069590 43.6 µM 0.178839077392867 0.41195153279248 no 1360 0.429032030285585 2082 6384066 SGTC_260 nsc-65238 3.989 µM 0.175848465102831 0.413151338083154 no 1361 0.43020649660124 2059 3246252 SGTC_321 4534-3890 65.3 µM 0.175809756322792 0.413166873023049 no 1362 0.430221702295458 2098 699746 SGTC_1889 st059080 5.18 µM 0.173558477371688 0.414070608744932 no 1363 0.431106233460961 2150 176925 Isolated from Daphnopsis sellowiana. SGTC_524 r073-0010 27.8 µM 0.172537079281482 0.414480781171916 no 1364 0.431507656689007 1919 2772106 SGTC_1459 k035-0031 35.7 µM 0.172155796707149 0.414633920329678 no 1365 0.431657524040387 1907 3877128 YMR208W ERG12 SGTC_84 0443-0269 128.823 µM 0.172084094840813 0.414662720272522 no 1366 0.431685708355056 2081 6150058 SGTC_757 1066-0008 322 µM 0.171030240053886 0.415086066942464 no 1367 0.432099993891368 2077 6842497 SGTC_2580 diallyl disulphide 81.36 µM 0.169866169165489 0.415553803411159 no 1368 0.432557693752323 1980 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1929 genistein trimethyl ether 50.5 µM 0.169791312787846 0.415583885628371 no 1369 0.432587129559923 2149 136420 SGTC_795 0685-0265 78 µM 0.169572967378082 0.415671634004186 no 1370 0.432672991761837 2144 302754 SGTC_2004 4023728 41.89 µM 0.169568606172976 0.415673386722601 no 1371 0.432674706795588 2122 360084 YDR527W RBA50 SGTC_35 0133-0054 64.071 µM 0.16933624165559 0.41576677378756 no 1372 0.432766085434105 1953 99677 SGTC_663 1486-0733 13.9 µM 0.168106842160965 0.41626094725018 no 1373 0.433249613344834 2005 722445 YPR165W RHO1 SGTC_3085 9117376 49.47 µM 0.166032571106509 0.417095027838818 no 1374 0.434065658932772 2019 16480349 SGTC_1237 0330-0133 46.1 µM 0.165852754091188 0.417167351299961 no 1375 0.43413641460698 2000 X1237 YHR072W ERG7 SGTC_491 tetrandrine 80.3 µM 0.165479439363344 0.417317509626423 no 1376 0.434283315868623 2097 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2128 5255449 168.493 µM 0.165366437185358 0.417362964854067 no 1377 0.43432778459592 2041 736008 SGTC_959 1222-0044 107 µM 0.164306443407804 0.417789401991451 no 1378 0.43474495476258 2155 6083612 SGTC_989 1501-0895 10.3 µM 0.164148382638491 0.417852998379307 no 1379 0.434807167248581 2129 2830112 SGTC_1959 st077091 55.8 µM 0.163913575946861 0.417947477764164 no 1380 0.434899589796161 2040 821356 YKL052C ASK1 SGTC_766 1391-0721 126 µM 0.163884244591069 0.41795928018166 no 1381 0.434911135196836 2095 1020919 YIL115C NUP159 SGTC_197 4544-0043 41.561 µM 0.163735711731293 0.418019048305021 no 1382 0.434969601514567 2118 896523 SGTC_3256 9138902 49.47 µM 0.163420773622462 0.418145782482533 no 1383 0.435093573880037 2118 17228773 SGTC_1879 gemcitabine 100 µM 0.159329952532178 0.419792736508335 no 1384 0.436704461734252 2074 60750 A nucleoside analog which inhibits DNA replication. SGTC_354 2783-3500 4.88 µM 0.1586473804586 0.420067675894812 no 1385 0.436973348641926 1963 6740761 SGTC_2257 7960413 200 µM 0.158300323520545 0.420207485071003 no 1386 0.437110076612294 2055 2974689 YIL048W NEO1 SGTC_1502 4534-4282 27.7 µM 0.156815960531747 0.420805562517961 no 1387 0.437694946897902 2026 3278949 SGTC_780 0109-0199 192 µM 0.156557826775426 0.420909588108699 no 1388 0.437796670968629 2147 610414 SGTC_2228 7354201 200 µM 0.156475926644262 0.420942594282044 no 1389 0.43782894662562 2087 753451 SGTC_714 4296-0578 26.1 µM 0.156387151711303 0.420978371663418 no 1390 0.437863932009712 2125 1589775 SGTC_1923 st058458 19.1 µM 0.156274056224968 0.42102395146985 no 1391 0.437908502603574 2153 3534982 SGTC_3169 9102970 49.47 µM 0.155146027253244 0.421478628176544 no 1392 0.438353098478089 2124 17027839 SGTC_676 falcarinol 140 µM 0.154931376838249 0.421565159590484 no 1393 0.438437708582197 2139 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1208 2323-2347 50.3 µM 0.154814534168978 0.421612263637221 no 1394 0.438483766374983 2154 5412760 SGTC_2664 lyso-paf C-16 73.48 µM 0.153494992098273 0.42214430258542 no 1395 0.439003969619333 2110 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1410 3909-8106 77.9 µM 0.153153389340454 0.422282059905377 no 1396 0.439138656925806 2130 1039210 SGTC_2959 9079155 11 µM 0.152814084644291 0.42241889990372 no 1397 0.439272445127168 2054 16189457 SGTC_1811 st050069 61.5 µM 0.152265850108338 0.422640020111863 no 1398 0.439488629239049 2162 3877702 SGTC_955 1216-0110 33 µM 0.151737378732063 0.42285319229452 no 1399 0.439697037271708 2048 3619719 SGTC_512 prima-1 270 µM 0.150368009655736 0.423405666618592 no 1400 0.440237139437056 2121 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2243 6634756 200 µM 0.149581585313411 0.423723019043053 no 1401 0.440547368750294 2132 885676 SGTC_3304 9125678 46.087 µM 0.148799606547033 0.424038626568921 no 1402 0.440855880556442 2036 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1353 1498-1206 8.11 µM 0.147970112566715 0.424373464541366 no 1403 0.44118317763582 2082 6756808 SGTC_3124 9127567 49.47 µM 0.147299158169672 0.424644345526579 no 1404 0.441447948457418 2150 17592030 SGTC_3071 9117417 49.47 µM 0.144469648037366 0.42578707924242 no 1405 0.442564811174526 2158 45595590 YGL055W OLE1 SGTC_2930 9013230 14.89 µM 0.144411687048006 0.425810494076477 no 1406 0.442587694307789 2120 2995857 SGTC_2795 7780010 54.55 µM 0.144190801529248 0.42589972886663 no 1407 0.442674902178988 2051 953673 SGTC_2917 7979103 53.79 µM 0.143794896041401 0.426059678872654 no 1408 0.442831216679368 2107 2980565 SGTC_2838 9002687 71.43 µM 0.143420927693625 0.426210777215155 no 1409 0.442978877960102 1963 6457060 SGTC_1727 st034309 9.9045 µM 0.142903619114673 0.426419808662393 no 1410 0.443183150135674 2170 870305 SGTC_831 k061-1017 217 µM 0.142606328140526 0.426539945859995 no 1411 0.443300549717106 2120 1240153 SGTC_554 4483-2211 187 µM 0.142597890654991 0.426543355601769 no 1412 0.44330388173511 2046 747107 SGTC_2425 5628681 7.85 µM 0.14250646595467 0.426580302342412 no 1413 0.443339986201877 2091 5714958 SGTC_2867 9039098 71.43 µM 0.140805700857475 0.427267736215605 no 1414 0.444011719652971 2116 6463460 SGTC_785 1270-0111 65.3 µM 0.14013617153707 0.427538414628011 no 1415 0.444276200904257 2196 6741994 SGTC_3078 9116413 49.47 µM 0.139408995409228 0.427832437225918 no 1416 0.444563482232228 2134 17177322 SGTC_3082 9117008 49.47 µM 0.139238965123224 0.427901192170979 no 1417 0.444630659334806 2021 41448529 SGTC_2475 5812728 15.03 µM 0.1391858736488 0.427922661156118 no 1418 0.444651635520427 2171 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2068 5226020 147 µM 0.13866774355704 0.428132192377817 no 1419 0.444856354351075 2051 1810509 SGTC_621 3584-0052 32.1 µM 0.136993475825137 0.428809402599512 no 1420 0.445517976014667 2162 2273927 SGTC_3067 9117431 49.47 µM 0.13633898035957 0.429074190971806 no 1421 0.445776654850866 2038 17150885 SGTC_673 1082-0474 110 µM 0.13449001571583 0.429822396256283 no 1422 0.446507552834837 2104 3098046 SGTC_1004 4084-0029 199 µM 0.134139661517365 0.429964199695907 no 1423 0.446646068837578 2169 716894 YLR208W SEC13 SGTC_881 0833-0569 170 µM 0.13226075362627 0.430724828377122 no 1424 0.447389024339142 1954 5418700 SGTC_2261 9010538 184.68 µM 0.130439519634823 0.431462354617425 no 1425 0.448109350758417 2017 6457250 SGTC_1872 amphotericin b 148 nM 0.129986390570789 0.431645890825107 no 1426 0.448288597041983 2151 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1977 st070720 65.3 µM 0.127436400891235 0.432679017289174 no 1427 0.449297503672646 2040 682188 SGTC_1573 oleylamine 1.06 µM 0.127194575402223 0.432777016720648 no 1428 0.449393199356235 2091 5356789 An amine of the fatty acid oleic acid. SGTC_2560 caryophyllene 100 µM 0.126792047518015 0.432940149733122 no 1429 0.449552495049563 2213 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2607 solasodine 47.35 µM 0.126760179135253 0.432953065563706 no 1430 0.449565106936256 2065 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3317 9138495 8.753 µM 0.126605649076917 0.433015695551214 no 1431 0.449626262804068 2198 17020139 SGTC_2972 9093619 59.92 µM 0.124846521880156 0.43372877612623 no 1432 0.450322528176368 1965 25236256 SGTC_112 phenothiazine 287.218 µM 0.12464082159064 0.433812173019877 no 1433 0.450403954709306 2189 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3286 9117135 37.221 µM 0.124402951943629 0.433908615982359 no 1434 0.45049811809662 2054 3438150 SGTC_2814 7977482 42.97 µM 0.123788373129143 0.434157811841913 no 1435 0.45074141895145 2149 6456762 SGTC_2499 avocadenofuran 51.48 µM 0.122678478281191 0.434607911813847 no 1436 0.451180853479072 2167 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2397 5161689 200 µM 0.122158807138342 0.434818685245178 no 1437 0.451386624599989 2142 2259942 SGTC_1085 doxorubicin 7.67 µM 0.121959987040927 0.434899329596095 no 1438 0.451465353680626 2197 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3153 9100258 49.47 µM 0.121424136372854 0.435116691972232 no 1439 0.451677550130082 2049 25236848 SGTC_2087 5276107 200 µM 0.120388332683551 0.43553691073755 no 1440 0.452087766675467 2177 144405 SGTC_3337 9144342 33.5465 µM 0.12015179098865 0.435632884380048 no 1441 0.452181453120264 2161 17682949 SGTC_275 trichlorophene 5.69 µM 0.120097448157588 0.435654933795756 no 1442 0.452202976918254 2107 62616 SGTC_2552 juarezic acid 87.02 µM 0.117501686769623 0.436708386746708 no 1443 0.45323125372777 2228 1549512 SGTC_1845 st056753 3.01 µM 0.117446577170712 0.436730757089877 no 1444 0.453253088096831 2151 5375839 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.117378955626877 0.436758206616016 no 1445 0.453279879879289 2087 2724 A muscle relaxant with antifungal properties. SGTC_3040 9091894 49.47 µM 0.117304440251251 0.436788454899057 no 1446 0.453309403257105 2159 25236966 SGTC_313 3474-0040 5.03 µM 0.117037442648156 0.436896841188937 no 1447 0.453415191208321 2152 1043375 YIL048W NEO1 SGTC_3092 9117248 49.47 µM 0.116854008849864 0.436971307932005 no 1448 0.453487872000585 2224 17141857 SGTC_102 gallobenzophenone 83.616 µM 0.115337114834072 0.437587191234275 no 1449 0.454088960630882 2196 70837 SGTC_2682 pyrogallin 40.03 µM 0.113331943380718 0.438401554883952 no 1450 0.454883696610322 2203 822798 An ATP competetive kinase inhibitor. SGTC_3315 9136395 68.55 µM 0.111914064085475 0.438977558254187 no 1451 0.455445772566348 2213 16876844 SGTC_2049 5262831 67.185 µM 0.108502959516207 0.440363822418732 no 1452 0.456798366510936 2127 763417 SGTC_2346 9031566 143.75 µM 0.108003810031853 0.440566737230935 no 1453 0.456996334961539 2175 4771086 SGTC_1211 1056-0033 32.3 µM 0.107884292563805 0.440615325925025 no 1454 0.457043738555317 2220 6741922 SGTC_2465 5809242 33.21 µM 0.10732363955228 0.440843266017024 no 1455 0.457266115600618 2160 2731748 SGTC_337 1315-0038 354 µM 0.107275091894246 0.440863004562959 no 1456 0.457285372142578 2108 1626437 SGTC_579 4491-1009 110 µM 0.107187069876064 0.440898793000705 no 1457 0.457320286537424 2258 1271041 SGTC_2235 salicylic acid 500 µM 0.106759226662937 0.441072754529924 no 1458 0.457489997477281 2227 338 A COX inhibitor and kinase inhibitor. SGTC_1278 0874-0585 172 µM 0.105209419468175 0.441703002823708 no 1459 0.458104818276015 2142 766306 SGTC_89 0302-0250 142.109 µM 0.104193765050535 0.442116111447912 no 1460 0.458507790905501 2241 4203518 YLR208W SEC13 SGTC_1713 st033146 12.748 µM 0.103112625905874 0.442555924586858 no 1461 0.458936792207537 2219 674619 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.101681727516055 0.443138130425307 no 1462 0.459504653146001 2214 6312947 SGTC_1796 st049173 110.4 µM 0.10073215815941 0.44352456032472 no 1463 0.459881541341573 2226 94134 SGTC_1160 4092-0570 10.5 µM 0.100462885356074 0.44363415143465 no 1464 0.459988423460793 2121 4994975 SGTC_2411 st077133 39.94 µM 0.10001061789708 0.443818229081223 no 1465 0.460167947923914 2218 1403142 YNL221C POP1 SGTC_1381 2324-0066 62.1 µM 0.0989211418224114 0.444261707081571 no 1466 0.460600441244026 2147 10885928 SGTC_2762 leflunomide 42.06 µM 0.0989076152373336 0.444267213601807 no 1467 0.460605811236213 2144 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_488 nitrendipine 139 µM 0.0986867861716339 0.444357112144689 no 1468 0.460693480377018 2252 4507 Dihydropyridine L-type calcium channel blocker. SGTC_277 nystatin 15.5 µM 0.0986457401825409 0.444373822102232 no 1469 0.460709775845701 2232 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_262 fenpropimorph 62.5 µM 0.0976819737139237 0.44476620296322 no 1470 0.461092414992599 2217 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1240 0356-0016 42.1 µM 0.0959863056005275 0.445456696097799 no 1471 0.461765724443514 2162 4305613 SGTC_1504 k297-0033 30 µM 0.095978741124082 0.445459776801127 no 1472 0.461768728364052 2158 4388117 SGTC_943 3253-1379 105 µM 0.0953997396962434 0.445695590272927 no 1473 0.461998661414423 2200 668464 SGTC_717 1532-0246 73.2 µM 0.0947401767830491 0.445964237919866 no 1474 0.462260602512831 2142 9561992 SGTC_2508 celastrol 40.54 µM 0.0947104929982865 0.445976329055003 no 1475 0.462272391619617 2235 122724 Celastrol is a natural product and antioxidant. SGTC_1175 0741-0056 27.6 µM 0.0944560289119659 0.446079982306539 no 1476 0.462373455033381 2220 765927 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0939311969236865 0.446293778690509 no 1477 0.462581905913414 2230 2346 DNA damaging agent; causes G2/M arrest. SGTC_2711 st079103 59.1 µM 0.0924647091717812 0.446891252020438 no 1478 0.463164414534338 2207 54693780 SGTC_2597 laccaic acid a 100 µM 0.0914518476569972 0.447303980384881 no 1479 0.463566782919025 2174 5491415 A textile dye. SGTC_2281 7943571 200 µM 0.0904326964552601 0.447719329322064 no 1480 0.463971687558031 2281 1244024 SGTC_2697 mebhydrolin 72.4 µM 0.0903037921037885 0.447771867608284 no 1481 0.46402290340136 2216 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1634 st006576 41 µM 0.0898222566941571 0.447968137855766 no 1482 0.464214230697106 2240 3915356 SGTC_24 0417-1663 219 µM 0.0885600694895707 0.44848265629822 no 1483 0.464715771637959 2152 4329390 SGTC_327 1273-0057 3.96 µM 0.0884843162097745 0.448513539157669 no 1484 0.464745874646501 2242 3108138 SGTC_318 1488-0629 67.2 µM 0.0874449803031754 0.448937283786146 no 1485 0.46515890858672 2138 3662576 SGTC_2889 9059656 51.95 µM 0.0871437625093823 0.449060103328368 no 1486 0.465278620110478 2201 3949838 SGTC_3105 9121040 49.47 µM 0.0866948453616521 0.449243155349835 no 1487 0.465457036898729 2260 41448907 SGTC_2204 7233102 200 µM 0.084084533370993 0.450307758086727 no 1488 0.466494610836886 2208 2172480 SGTC_3086 9117350 49.47 µM 0.0832556301388086 0.450645897326063 no 1489 0.466824139887904 2267 2679265 SGTC_2909 7941780 10.49 µM 0.0830106806671208 0.450745827834491 no 1490 0.466921523491427 2257 1243215 SGTC_2140 5586273 200 µM 0.0820448771999736 0.451139871017036 no 1491 0.467305513439135 2267 854421 SGTC_2493 resveratrol 26.09 µM 0.0793429103628133 0.452242515111378 no 1492 0.468379938163652 2255 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_105 0111-0055 734.78 µM 0.0787958930670721 0.452465792208209 no 1493 0.468597485374959 2195 5179370 SGTC_3083 9117465 49.47 µM 0.0785545134070544 0.452564321390488 no 1494 0.468693484359842 2105 16420915 SGTC_1321 1326-2144 215 µM 0.0778338642181613 0.452858501788563 no 1495 0.468980104199359 2262 3513030 SGTC_3023 9089636 49.47 µM 0.0766461754070662 0.453343391538965 no 1496 0.46945251215266 2292 17249241 SGTC_2798 7813637 45.45 µM 0.0764385357688019 0.453428170347079 no 1497 0.469535106080727 2218 956368 SGTC_1302 1159-0335 255 µM 0.0760498882047836 0.453586859995041 no 1498 0.469689704018733 2227 649284 SGTC_838 0109-0203 71.4 µM 0.0734437404643386 0.45465117285864 no 1499 0.470726505848841 2285 759422 SGTC_438 sphingosine 6.67 µM 0.0733488858753025 0.454689916282523 no 1500 0.470764245565579 2226 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2911 7942208 15.64 µM 0.0732228518849369 0.454741395621706 no 1501 0.470814391011053 2175 1243384 SGTC_1402 3909-7673 35.9 µM 0.0723966329553256 0.455078888484061 no 1502 0.471143132138892 2273 5328014 SGTC_1326 1431-2094 10.8 µM 0.0720445474508769 0.455222717792299 no 1503 0.47128322809818 2268 616278 SGTC_2513 baicalein 25.65 µM 0.0719622595248387 0.455256333813164 no 1504 0.471315971242671 2210 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3243 9134147 49.47 µM 0.0719551812625526 0.455259225418967 no 1505 0.471318787759279 2292 24282180 SGTC_1071 trifluoperazine 6.31 µM 0.0707317176788605 0.455759069224531 no 1506 0.47180563849531 2239 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_280 3448-3607 3.04 µM 0.0704195315191986 0.455886623554363 no 1507 0.471929872966751 2285 626179 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.070277773103167 0.455944545304116 no 1508 0.471986286625903 2205 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3220 9131269 49.47 µM 0.069745816519502 0.456161908330023 no 1509 0.472197987118651 2295 17722206 SGTC_1084 voriconazole 435 nM 0.0690797667437087 0.456434081727477 no 1510 0.472463063174166 2278 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1898 st060199 18.6 µM 0.0681595011116807 0.456810171048207 no 1511 0.472829332696946 2281 688866 SGTC_2040 5100729 123 µM 0.0678359972203381 0.456942388125931 no 1512 0.472958094055606 2238 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_114 0364-0001 490.298 µM 0.0671291363907603 0.457231300979603 no 1513 0.473239449359631 2151 4003655 SGTC_42 0133-0086 60.653 µM 0.0656624881519939 0.45783083112816 no 1514 0.473823269024613 2293 162923 Model of phenazepam hydroxylation. SGTC_1699 st031318 29.054 µM 0.064590006493428 0.458269296381319 no 1515 0.474250220879185 2255 5340658 SGTC_2303 7774051 200 µM 0.0600219814108794 0.460137415419029 no 1516 0.476069063808051 2278 2953184 SGTC_2919 7978188 46.38 µM 0.0593438542733664 0.460414815287335 no 1517 0.476339115991182 2303 2980291 SGTC_394 menadione 8.33 µM 0.0591400540200352 0.460498187147576 no 1518 0.476420277980387 2317 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1921 5740136 50 µM 0.0587517026702275 0.460657061109023 no 1519 0.476574938825402 2290 1774243 SGTC_2467 5474540 200 µM 0.0576740275579797 0.461097969217679 no 1520 0.477004141128032 2290 5413519 SGTC_1930 st074634 34.3 µM 0.0570536851580279 0.461351790987628 no 1521 0.477251215088869 2311 684253 YOR116C RPO31 SGTC_1833 st055984 71 µM 0.0569296140243698 0.461402558320037 no 1522 0.477300631990391 2191 676288 SGTC_344 k064-0035 6.43 µM 0.055110924481016 0.462146800082337 no 1523 0.478025046447905 2239 5088750 SGTC_1284 0929-0043 16 µM 0.0550257202003465 0.462181670537668 no 1524 0.478058986536889 2228 1239883 SGTC_21 0849-0113 22.993 µM 0.0549513311249416 0.462212115031328 no 1525 0.478088618650505 2287 1560156 SGTC_3203 9113543 49.47 µM 0.0525279300644224 0.463204036886761 no 1526 0.4790540205379 2251 17018012 SGTC_2151 5563267 85.4165 µM 0.0517285810410269 0.463531268779939 no 1527 0.479372481671609 2237 5310824 SGTC_1259 0671-0132 43 µM 0.0511916700003916 0.463751079520658 no 1528 0.479586394759985 2257 X1259 SGTC_1980 st071811 45.7 µM 0.0510347758894418 0.463815313875134 no 1529 0.479648904745376 2275 4974850 SGTC_3017 9080681 49.47 µM 0.0510018129570002 0.463828809419968 no 1530 0.479662037949698 2247 16451914 SGTC_1256 0570-0116 285 µM 0.0504388656337121 0.464059295352063 no 1531 0.479886332744906 2259 410638 SGTC_3259 9138485 49.47 µM 0.0503876133781263 0.464080280018512 no 1532 0.479906753470546 2313 17646153 SGTC_1376 2910-0861 41.3 µM 0.0489800652955207 0.464656623792611 no 1533 0.480467591229316 2320 1112859 SGTC_1527 coumarin 137 µM 0.0484127196617915 0.464888953857099 no 1534 0.480693661184005 2278 323 A hepatotoxic, DNA x-linker. SGTC_271 rotenone 740 µM 0.047622015819418 0.4652127698558 no 1535 0.481008742923469 2259 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3280 9140961 49.47 µM 0.0475122404884448 0.465257727841806 no 1536 0.481052487427463 2291 4901226 SGTC_4 0960-0234 25.671 µM 0.0468440200604998 0.465531404014425 no 1537 0.481318772293659 2231 6821112 SGTC_1875 nocodazole 6 µM 0.0465783051636756 0.465640234671215 no 1538 0.481424661615498 2329 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3230 9131665 49.47 µM 0.0462983423533243 0.465754903722821 no 1539 0.481536230252361 2304 15943720 SGTC_1192 1488-0095 21.4 µM 0.0449767700417872 0.466296240433654 no 1540 0.482062912516696 2250 915875 SGTC_2839 9003951 25.97 µM 0.044078300786129 0.466664303178556 no 1541 0.482420994717329 2362 2990634 SGTC_1697 st025554 27.742 µM 0.0437527563704288 0.466797671245708 no 1542 0.482550742973451 2322 1269519 SGTC_2377 9073351 62.6 µM 0.04361004644044 0.46685613740122 no 1543 0.482607621708259 2303 7337946 YHR072W ERG7 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0434817635819429 0.466908693608521 no 1544 0.482658750664805 2338 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1359 1582-0056 520 nM 0.0419381306765005 0.467541149587834 no 1545 0.483274009620083 2300 3661189 SGTC_1394 3474-0001 65.7 µM 0.0411033713462326 0.467883200722964 no 1546 0.48360674346554 2286 5017666 YIL048W NEO1 SGTC_2750 bromebric acid 70.15 µM 0.0392055288756984 0.468660948846576 no 1547 0.484363262810942 2294 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0382994566876575 0.469032305460176 no 1548 0.484724461985192 2338 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1120 ficusin 1.78878 µM 0.0379931947126305 0.469157834028875 no 1549 0.48484655397251 2278 6199 A DNA cross-linker. SGTC_2456 5770359 74.46 µM 0.0378737797911256 0.469206779833581 no 1550 0.484894159370376 2331 3118787 SGTC_2370 9071495 200 µM 0.0377361846431843 0.46926317792903 no 1551 0.484949012679783 2207 21791103 SGTC_2511 berberine 10.47 µM 0.0372613408790075 0.469457813678206 no 1552 0.485138314791058 2327 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_952 1185-0122 232 µM 0.0369892843578863 0.469569331385417 no 1553 0.48524677486924 2336 678600 SGTC_812 4251-0442 148 µM 0.0367309941266176 0.469675208411547 no 1554 0.485349747785956 2337 5723007 SGTC_293 4049-0273 38.5 µM 0.0354914856955164 0.470183331146179 no 1555 0.485843917765183 2299 1380311 SGTC_2902 5787006 60.46 µM 0.0351306267142335 0.470331270445782 no 1556 0.485987789946331 2320 591003 SGTC_1752 st044819 83.042 µM 0.034593191626451 0.47055160723015 no 1557 0.486202065273621 2317 441209 YML126C ERG13 SGTC_1806 st050005 60.3 µM 0.0340773691575378 0.470763091787605 no 1558 0.486407727398916 2302 5194765 SGTC_2368 9071271 200 µM 0.0324803429704839 0.471417916328431 no 1559 0.487044495897656 2313 27209959 SGTC_1098 clofazimine 15.1 µM 0.0323553963889079 0.471469151136419 no 1560 0.487094316186401 2328 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1553 gossypol 38.6 µM 0.0322727795256726 0.471503028746195 no 1561 0.487127258342615 2334 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2653 dihydrofissinolide 100 µM 0.0300202188609619 0.472426785281409 no 1562 0.488025464058789 2317 6857746 SGTC_2784 7567673 72.73 µM 0.0296173720545747 0.472592005210414 no 1563 0.488186105247513 2353 3471247 SGTC_2101 5377231 179.231 µM 0.0290391265605827 0.472829169799144 no 1564 0.488416692629547 2316 2844213 SGTC_3 0833-0587 95.581 µM 0.0283758530598967 0.473101220069361 no 1565 0.488681191455754 2278 5382644 SGTC_2008 4012253 172 µM 0.0277527652176804 0.473356799100368 no 1566 0.488929669665735 2342 603940 SGTC_2781 5567276 71.43 µM 0.0270240315217128 0.473655726001101 no 1567 0.489220283323145 2345 2853274 SGTC_3340 9146634 11.102 µM 0.0265919746441841 0.473832962948813 no 1568 0.489392587151952 2318 4907387 SGTC_364 0083-0097 67.7 µM 0.0265132605150981 0.473865253358125 no 1569 0.489423978478057 2331 5207356 SGTC_2952 9073731 13.78 µM 0.0262764950117721 0.473962381237263 no 1570 0.489518401350209 2351 16457353 SGTC_2414 st077232 92.9 µM 0.0262176635360569 0.473986515806184 no 1571 0.489541863630205 2324 729801 SGTC_1826 st055655 41.6 µM 0.0261666249562542 0.474007453555191 no 1572 0.489562218094549 2265 676168 SGTC_633 0437-0093 97.7 µM 0.0250610558924634 0.474461012845144 no 1573 0.490003131657006 2365 2831118 SGTC_1054 3429-0080 167 µM 0.0248659006351247 0.474541078669752 no 1574 0.490080963085189 2359 1162877 SGTC_76 0433-0009 400.328 µM 0.0221027405572022 0.475674821781168 no 1575 0.491183000181329 2241 2841569 SGTC_390 dec-rvkr-cmk 16.7 µM 0.0217773695100153 0.475808336844279 no 1576 0.491312773210376 2348 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1611 st001856 99.4 µM 0.0205437836160945 0.476314559774044 no 1577 0.491804792580689 2352 647478 SGTC_1673 st016611 27.3 µM 0.0174853245221751 0.477569813582642 no 1578 0.4930247201964 2351 5226799 SGTC_1146 3579-1023 7 µM 0.0169428118105709 0.477792495429366 no 1579 0.493241119387533 2375 X1146 SGTC_110 0850-0284 111.64 µM 0.0165852798300213 0.477939253171058 no 1580 0.493383733969284 2374 3906265 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0165504662514435 0.47795354341559 no 1581 0.493397620671668 2381 688664 SGTC_2330 7979373 200 µM 0.0156650845107311 0.478316983545172 no 1582 0.493750791050959 2361 1863007 SGTC_2251 lansoprazole 556 µM 0.0146720302759532 0.478724643570038 no 1583 0.494146916781726 2353 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_295 k015-0027 31 µM 0.014162661814961 0.478933753763189 no 1584 0.494350104276563 2356 3887424 SGTC_2564 betulinic acid 100 µM 0.013562774049844 0.479180032128521 no 1585 0.494589401871369 2381 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2123 5259487 200 µM 0.0131441385581794 0.47935190376675 no 1586 0.494756398378214 2380 2173474 SGTC_2115 tiliquinol 12.7705 µM 0.0128100510094137 0.479489066834027 no 1587 0.494889668803978 2363 71208 A bioactive hydroxyquinoline. SGTC_1675 st018485 24.5 µM 0.0122884982994779 0.479703200494232 no 1588 0.495097721845883 2318 3323024 SGTC_1693 xanthone 101.9 µM 0.0122674019097217 0.479711862153112 no 1589 0.495106137453378 2365 7020 An insecticide. SGTC_688 0527-0193 473 µM 0.0120276258047994 0.479810308998007 no 1590 0.495201787221832 2379 4007154 SGTC_1775 st081588 35.1725 µM 0.0110192352009114 0.480224345621889 no 1591 0.495604050142817 2379 1426443 YGL099W LSG1 SGTC_3149 9097855 49.47 µM 0.01028438305101 0.480526083143254 no 1592 0.495897197097811 2382 25236625 YMR079W SEC14 SGTC_646 4092-0839 27.3 µM 0.00914832944138584 0.480992579828036 no 1593 0.496350395497936 2376 877796 SGTC_2981 9013952 38.96 µM 0.00871957899615485 0.481168644042794 no 1594 0.496521435351014 2370 2996344 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.00839196367791655 0.481303180103732 no 1595 0.496652130168985 2354 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1109 tnp00067 928.257 nM 0.00804635792474434 0.481445106290146 no 1596 0.496790002258563 2377 676295 SGTC_909 3448-9333 149 µM 0.0064669502243778 0.482093734272277 no 1597 0.497420078112934 2387 3344074 SGTC_3185 9108267 49.47 µM 0.00646099321958208 0.482096180773848 no 1598 0.497422454564363 2387 4910486 SGTC_492 tmb-8 126 µM 0.00613805738512533 0.482228809342983 no 1599 0.497551284765749 2391 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2969 9091408 28.7 µM 0.00532364536377127 0.482563294090413 no 1600 0.497876182810455 2391 4286311 SGTC_131 0141-0277 33.849 µM 0.0047420207265467 0.48280217894754 no 1601 0.498108214527664 2393 1547771 SGTC_1391 3442-0225 151 µM 0.00392491688288839 0.483137790228971 no 1602 0.498434188728569 2396 5227075 SGTC_2181 6316240 54.2555 µM 0.00387140458123672 0.483159769901446 no 1603 0.498455536886016 2390 12779990 SGTC_2671 danthron 100 µM 0.00369239473135694 0.483233296878097 no 1604 0.498526950972935 2396 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1605 st000082 49.1 µM 0.00357829108216538 0.483280164408859 no 1605 0.498572471442127 2383 1114022 SGTC_2441 5730946 39.09 µM 0.00301600942926904 0.483511122283223 no 1606 0.498796788144707 2393 1774275 SGTC_987 1497-1013 404 µM 0.00217148427152818 0.483858022392562 no 1607 0.499133703793675 2399 1676435 SGTC_690 glyoxal 20.3 µM 0.00175664523629635 0.484028427617944 no 1608 0.499299200303997 2401 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1463 k081-0032 34.1 µM 0.00131683466229941 0.484209093695548 no 1609 0.499474659128739 2386 977755 SGTC_1950 st077106 7.18 µM 0.00126076516773824 0.48423212624426 no 1610 0.49949702760218 2398 13831864 SGTC_1038 k292-0204 154 µM 9.56161230672244e-05 0.484710764646518 no 1611 0.499961854685879 2387 4454212 SGTC_1106 tegaserod maleate 11.7 µM -0.000283432837087325 0.484866481172302 no 1612 0.499886926659146 2406 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2434 5670830 169.91 µM -0.00130200121310671 0.485284929062078 no 1613 0.499480576813713 2408 1549830 SGTC_612 0302-0167 22.4 µM -0.00136266738199886 0.485309852431386 no 1614 0.499456374535436 2407 235821 SGTC_3311 9131146 2.8755 µM -0.00175440546859949 0.485470790838185 no 1615 0.499300093840653 2414 4900406 YPR165W RHO1 SGTC_1124 fisetin 1.16336 µM -0.00233574818302254 0.485709629182468 no 1616 0.49906817214072 2414 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1489 4065-0444 182 µM -0.00248825663665441 0.485772286477618 no 1617 0.499007330247489 2414 2877968 SGTC_1076 itraconazole 331 nM -0.00276054191876196 0.485884154324464 no 1618 0.498898704510539 2416 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1715 st032160 10.2275 µM -0.00347485400517786 0.486177633229768 no 1619 0.498613736608878 2413 5289825 SGTC_1719 st032227 49.2 µM -0.00350031013345537 0.486188092154038 no 1620 0.498603581144775 2417 3125804 SGTC_1893 st059353 36.1 µM -0.00413637558837767 0.486449429557579 no 1621 0.498349829595804 2423 3112488 SGTC_505 gw-5074 63.9 µM -0.00448650107085507 0.486593286558336 no 1622 0.498210151036325 2423 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2025 5147754 141 µM -0.00598400122489025 0.487208587940496 no 1623 0.497612743152682 2424 315777 YLR208W SEC13 SGTC_894 0960-0238 55.9 µM -0.00637835000470396 0.48737062533548 no 1624 0.497455423757584 2404 6741907 YDL195W SEC31 SGTC_193 1273-0060 1.558 µM -0.00667511913454618 0.48749256875697 no 1625 0.497337032526263 2418 2847393 YHR072W ERG7 SGTC_1539 benzyladenosine 56 µM -0.00689347294374735 0.487582291810029 no 1626 0.497249923964541 2421 92208 A nucleotide analog. SGTC_514 4466-0038 2.65 nM -0.00869453541769363 0.488322384083649 no 1627 0.496531425914601 2452 5722064 SGTC_2032 5185112 25.99 µM -0.00901219995207276 0.488452922982448 no 1628 0.496404701067964 2418 5718189 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0101182032266696 0.488907425991317 no 1629 0.495963489806303 2432 6708760 SGTC_880 0833-0487 87.2 µM -0.0102137804916861 0.488946703372096 no 1630 0.495925361964514 2425 76075 SGTC_2259 7964009 200 µM -0.0114297262708272 0.489446404292174 no 1631 0.495440298216243 2472 313134 SGTC_649 1123-0311 367 µM -0.012034238724753 0.489694838877494 no 1632 0.495199149239388 2431 693629 YIL048W NEO1 SGTC_1730 st033808 45.1 µM -0.0128335810458045 0.490023348204403 no 1633 0.494880282449187 2452 1045166 SGTC_1926 methyl fluorone black 53.6 µM -0.0144241648044948 0.490677057515297 no 1634 0.494245790334184 2431 72721 Reacts with homocysteine. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0145316752824553 0.490721243851628 no 1635 0.494202904353864 2438 6708514 SGTC_3355 9151058 44.0485 µM -0.0149122955019224 0.490877678008969 no 1636 0.494051075310825 2430 17015728 SGTC_1415 3966-0071 78.1 µM -0.0149466260532625 0.49089178786701 no 1637 0.494037380928634 2442 2893185 SGTC_2198 6589944 200 µM -0.0150418595772482 0.490930928908971 no 1638 0.493999392520075 2441 5290268 SGTC_2145 5634607 200 µM -0.0156864638539492 0.491195863974183 no 1639 0.493742262974888 2431 308662 SGTC_2440 5628896 157.78 µM -0.01579898626146 0.49124211155777 no 1640 0.493697378591332 2441 5522048 SGTC_3038 9091290 49.47 µM -0.0164527506535988 0.491510816110997 no 1641 0.493436598247869 2447 25236843 SGTC_85 0868-0259 160.055 µM -0.016668532647937 0.49159950580076 no 1642 0.49335052549089 2486 83173 SGTC_489 paxilline 115 µM -0.0168102494440172 0.491657753790961 no 1643 0.493293996589596 2461 105008 A toxic potassium channel blocker. SGTC_2898 9056270 58.44 µM -0.0172166576930674 0.491824795408943 no 1644 0.493131886620741 2436 19154699 SGTC_549 1661-1316 519 µM -0.0182523378656216 0.492250486321328 no 1645 0.49271877499887 2438 2857282 SGTC_2059 5238311 157 µM -0.0192791638662982 0.492672546658157 no 1646 0.492309202833041 2438 703021 SGTC_1983 st071813 46.9 µM -0.0219548751182048 0.493772392147762 no 1647 0.491241975645501 2487 11838595 SGTC_1159 4092-0538 61.2 µM -0.0223274709519092 0.493925550828086 no 1648 0.491093367845375 2437 717301 SGTC_2129 girgensonine 121.053 µM -0.0228355602718173 0.494134406694771 no 1649 0.490890721209487 2473 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2875 9039966 71.43 µM -0.0228810019398424 0.494153086086005 no 1650 0.490872597342309 2518 6463691 SGTC_1755 st041960 45.185 µM -0.0236916759238837 0.494486326332578 no 1651 0.490549272897109 2465 2257073 SGTC_2539 epi(13)torulosol 80 µM -0.0239163644213293 0.494578688751839 no 1652 0.490459660547928 2471 6708597 SGTC_797 k781-0471 270 µM -0.0243275346125647 0.494747708716407 no 1653 0.49029567509128 2503 23738129 SGTC_2639 lactacystin 53 µM -0.0253074513845087 0.495150527406527 no 1654 0.489904865245289 2472 3870 A proteasome inhibitor. SGTC_841 0251-0215 91.2 µM -0.0261417094203991 0.495493473433331 no 1655 0.489572154556188 2495 3888614 SGTC_2300 7976697 71.57 µM -0.026467520832811 0.495627408607685 no 1656 0.48944221956983 2464 2236109 SGTC_798 1287-0182 476 µM -0.0267239405925549 0.495732818476993 no 1657 0.489339959058925 2445 1649755 SGTC_2312 7706453 155.7 µM -0.0267462341499815 0.495741982999313 no 1658 0.489331068394222 2463 976098 SGTC_2645 abamectin 100 µM -0.0268883093859345 0.495800387892647 no 1659 0.489274408953088 2453 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1726 st035556 14.5795 µM -0.028611602455525 0.49650881334798 no 1660 0.488587179226137 2638 5919439 SGTC_196 k015-0023 18.111 µM -0.0292908690871527 0.496788054997589 no 1661 0.488316304596154 2449 5211998 SGTC_2200 6600604 21.907 µM -0.0294007571483428 0.496833229344371 no 1662 0.488272484474953 2459 2904777 SGTC_3322 9139058 2.11 µM -0.0296085238425557 0.496918641141929 no 1663 0.488189633625989 2556 4908926 YPR165W RHO1 SGTC_3299 9121982 43.1275 µM -0.0296656061937753 0.496942107421827 no 1664 0.488166871061635 2483 17594604 YPL160W CDC60 SGTC_1812 st052057 4.327 µM -0.0299493366987612 0.497058747822479 no 1665 0.488053729240927 2448 3645418 SGTC_2088 5278280 127.392 µM -0.0305721991300448 0.497314804779736 no 1666 0.48780535683132 2486 791502 SGTC_425 3825-7017 13.1 µM -0.032775110475898 0.498220423468743 no 1667 0.486926963254714 2632 3397440 SGTC_3261 9137475 49.47 µM -0.0328441953885068 0.498248824506531 no 1668 0.486899417192433 2459 17027690 SGTC_1480 1070-0044 41.2 µM -0.0331130941963802 0.498359369785694 no 1669 0.486792200409006 2543 3124987 SGTC_187 1488-2104 32.728 µM -0.0333563082777577 0.49845935608899 no 1670 0.486695225600324 2520 2852859 SGTC_1383 3049-0032 20.7 µM -0.0335416793400348 0.498535562955951 no 1671 0.486621314604803 2477 712864 SGTC_1 0258-0098 57.368 µM -0.0344113329150593 0.498893082070625 no 1672 0.48627457323275 2434 6790032 YDR047W HEM12 SGTC_1604 st002052 72.4 µM -0.0344770420408808 0.498920095474244 no 1673 0.486248374629905 2554 6254834 YHR062C RPP1 SGTC_2024 5144227 134 µM -0.0352501415935184 0.499237921533121 no 1674 0.485940139921029 2489 3475211 SGTC_408 cantharidin 100 µM -0.0357006252095554 0.499423118399704 no 1675 0.48576053601306 2510 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2239 6685329 187.64 µM -0.0358076794881841 0.499467129158715 no 1676 0.485717854824707 2590 805680 SGTC_1207 2099-0101 141 µM -0.0364695934891532 0.499739246734706 no 1677 0.485453961727152 2472 5837381 SGTC_2764 methyldopa 94.69 µM -0.0368573039909681 0.499898637357133 no 1678 0.485299391538588 2490 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2796 7949634 45.45 µM -0.0373504240584736 0.499898637357133 no 1679 0.485102800466064 2471 2971588 SGTC_2948 9070189 9.45 µM -0.0383784585193365 0.499476004976013 no 1680 0.484692967968966 2485 6473636 YDL196W YDL196W SGTC_2170 morpholine 200 µM -0.0396464539426288 0.498954723773448 no 1681 0.484187495820655 2507 121171 Reacts with secondary amines. SGTC_2252 omeprazole 400 µM -0.0404606228098802 0.498620014517876 no 1682 0.483862949881761 2545 4594 A proton pump inhibitor. SGTC_2717 st081029 62.2815 µM -0.0422813998484092 0.497871487027427 no 1683 0.483137186397995 2478 5292846 SGTC_3074 9116018 49.47 µM -0.0424534591081866 0.497800753240408 no 1684 0.483068606262889 2472 17027303 SGTC_2474 5321570 43.32 µM -0.0425521542096963 0.497760179585989 no 1685 0.48302926816201 2598 2841384 SGTC_1417 3966-0327 90.4 µM -0.0428975003673909 0.497618207622108 no 1686 0.482891620667981 2480 651118 SGTC_1230 0170-0365 3.77 µM -0.0431805741143899 0.497501836098992 no 1687 0.482778795127301 2539 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1805 st050013 60.3 µM -0.043279083578715 0.497461338940369 no 1688 0.48273953224172 2522 4037144 SGTC_472 calcifediol 10 µM -0.0438484350643589 0.497227279545052 no 1689 0.482512609294256 2540 5283731 A vitamin D metabolite. SGTC_3327 9140648 26.9345 µM -0.0438940273912574 0.497208536659783 no 1690 0.482494438082741 2488 8029710 SGTC_1922 5578187 25 µM -0.0439231828560139 0.49719655092839 no 1691 0.482482817942162 2496 1350412 SGTC_1148 3909-7663 27.7 µM -0.0444454515274166 0.496981848152668 no 1692 0.482274666171524 2593 4084526 SGTC_3215 9129942 49.47 µM -0.0444624000505944 0.496974880689949 no 1693 0.482267911366595 2492 17682944 SGTC_517 1365-0151 113 µM -0.0457869504854446 0.496430366902994 no 1694 0.481740029953496 2611 768657 SGTC_3065 9113888 49.47 µM -0.045863643361675 0.496398839170631 no 1695 0.481709466030897 2550 16648368 SGTC_1464 k208-0027 110 µM -0.0459206313108456 0.496375411966157 no 1696 0.481686755056758 2479 X1464 SGTC_2229 7354935 190 µM -0.0464828853854354 0.496144275340791 no 1697 0.481462687412365 2486 318112 SGTC_1040 k898-0338 155 µM -0.0482592614502074 0.495414035046332 no 1698 0.480754810677221 2490 20969351 SGTC_770 0389-1121 67.2 µM -0.048461447013471 0.495330920665701 no 1699 0.480674244573725 2644 6753108 SGTC_2490 carminic acid 95.39 µM -0.0507645951651144 0.494384158401078 no 1700 0.479756551724265 2490 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_786 4544-0069 423 µM -0.0513314639622056 0.494151138529203 no 1701 0.479530698264397 2610 748821 YLR208W SEC13 SGTC_2421 5690543 90.72 µM -0.0518102273275396 0.493954337260156 no 1702 0.479339953134507 2536 3397993 SGTC_449 xestospongin c 11.1929 µM -0.0523173999063082 0.493745859658394 no 1703 0.479137894591257 2553 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1032 k061-1018 98.7 µM -0.0529935149361738 0.493467939491625 no 1704 0.478868537393006 2679 4005393 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0539167599514215 0.493088440564516 no 1705 0.47850074178895 2493 1377 SGTC_893 0958-0369 48.9 µM -0.0557704490754427 0.492326502766937 no 1706 0.477762338256487 2637 6819948 SGTC_1215 3852-0577 11.2 µM -0.0565874642887087 0.49199068669536 no 1707 0.477436910296178 2607 2884876 SGTC_3251 9135047 49.47 µM -0.0566283640118532 0.491973875914051 no 1708 0.477420619789387 2586 17682963 SGTC_1169 aniline yellow 25.8 µM -0.0574536573982824 0.491634663339496 no 1709 0.477091910565141 2543 6051 A DNA damaging agent. SGTC_2308 7584454 197.62 µM -0.0576185620076765 0.491566884866982 no 1710 0.477026231945694 2525 893577 SGTC_1176 0848-0131 83.3 µM -0.0584469327614465 0.49122641475777 no 1711 0.476696315851261 2547 6769040 SGTC_1572 epiandrosterone 68.9 µM -0.0588323710504016 0.491067997257955 no 1712 0.476542812368481 2531 441302 A steroid. SGTC_10 0279-0212 42.575 µM -0.059161935277963 0.490932545456306 no 1713 0.476411563879417 2518 39851 YBR002C RER2 SGTC_627 1391-0720 175 µM -0.0603687173612756 0.490436563752247 no 1714 0.475930986564814 2561 997839 SGTC_1089 terbinafine 2.25 µM -0.060630548148447 0.490328954468169 no 1715 0.475826722183044 2543 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2288 7946289 167.31 µM -0.0607947334126046 0.490261476670654 no 1716 0.47576134234638 2537 1246052 SGTC_2302 7771753 200 µM -0.0609219842168757 0.490209178600015 no 1717 0.475710670544902 2559 2203047 SGTC_1088 bifonazole 369 nM -0.0609398448204889 0.490201838187487 no 1718 0.475703558409401 2483 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2994 9053520 71.4286 µM -0.0620077684841798 0.489762945353368 no 1719 0.475278322776337 2552 4647384 SGTC_1024 4507-0395 26 µM -0.0632587449997894 0.489248837678009 no 1720 0.474780233327409 2668 4201836 SGTC_2977 9011197 71.43 µM -0.0643065078810167 0.488818257422047 no 1721 0.474363085821506 2693 2704722 SGTC_2543 pimpinellin 60.67 µM -0.0649649021583525 0.488547695609908 no 1722 0.474100972609014 2521 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_968 1309-0633 340 µM -0.0657962663569872 0.488206060749871 no 1723 0.473770014406149 2520 3761976 SGTC_428 3448-4153 16.5 µM -0.0658011594844036 0.488204050028444 no 1724 0.473768066551896 2498 3834874 SGTC_3051 9093778 49.47 µM -0.066456234557445 0.487934864285241 no 1725 0.473507300203081 2527 17217378 SGTC_383 2324-0395 7.37 µM -0.0665184442677414 0.48790930113706 no 1726 0.473482536913811 2607 3146421 SGTC_2290 7904846 200 µM -0.0667442171540365 0.4878165272001 no 1727 0.473392666286337 2570 2962154 SGTC_3016 9080866 49.47 µM -0.0680190299950088 0.487292697336659 no 1728 0.472885242810401 2528 17066299 SGTC_1244 0416-0015 52.5 µM -0.0685194384512004 0.487087081805992 no 1729 0.472686073396328 2558 96201 SGTC_385 1494-0393 12.4 µM -0.07043476743513 0.486300114132813 no 1730 0.471923809771041 2569 3090647 SGTC_362 0310-0100 9.03 µM -0.070477122627816 0.486282711882578 no 1731 0.471906954381263 2599 790235 SGTC_1509 1326-1131 80 µM -0.0708245667475916 0.486139960374634 no 1732 0.471768689740347 2519 768313 SGTC_1484 3473-2379 286 µM -0.0714239715105734 0.485893692054796 no 1733 0.471530165910182 2519 671917 SGTC_1991 st073000 8.92 µM -0.0720566965494842 0.485633739778429 no 1734 0.471278393873312 2695 4301969 YIL048W NEO1 SGTC_1053 3366-3204 134 µM -0.0720869109013677 0.485621326497792 no 1735 0.471266371356005 2572 3632071 YPR165W RHO1 SGTC_2227 7312221 64.1025 µM -0.0722917555798143 0.485537168367582 no 1736 0.471184862812667 2547 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2708 st078559 56 µM -0.0740634114839765 0.484809330759388 no 1737 0.470479964338163 2532 17250902 SGTC_485 niflumic acid 177 µM -0.0741673544567661 0.484766630107482 no 1738 0.470438610826982 2638 4488 A COX2 inhibitor. SGTC_3211 9128781 49.47 µM -0.0742147668275925 0.48474715276273 no 1739 0.470419748012571 2666 17194361 SGTC_2774 tamoxifen 10.92 µM -0.0748528460316933 0.484485028771385 no 1740 0.470165897331141 2527 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_278 4092-0821 23.9 µM -0.0749539982104898 0.484443475901956 no 1741 0.470125656494829 2615 877900 SGTC_1288 0973-0013 65.5 µM -0.0764856082780225 0.483814318138749 no 1742 0.469516381682251 2614 4315430 SGTC_1554 st069299 38.7 µM -0.0766760940364943 0.483736072813929 no 1743 0.469440611367876 2601 24207999 SGTC_1254 0550-0035 264 µM -0.0766927466972131 0.483729232474814 no 1744 0.469433987422152 2619 15121435 SGTC_1522 st012842 45.6 µM -0.0775448250672487 0.483379234482219 no 1745 0.469095066677194 2539 3491067 YOR116C RPO31 SGTC_2037 5169046 200 µM -0.0776625473277997 0.483330880124776 no 1746 0.469048243495008 2621 5718022 SGTC_3277 9138724 49.47 µM -0.0776724903931357 0.483326796027066 no 1747 0.469044288731902 2586 15943418 SGTC_2612 dictamnine 15.46 µM -0.0778767746441471 0.483242886995256 no 1748 0.468963037219954 2625 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_985 1493-0307 8.71 µM -0.078041275919425 0.483175319218947 no 1749 0.468897609829604 2567 3278274 SGTC_2116 5511452 16.8835 µM -0.0796019111619177 0.482534323251865 no 1750 0.468276937577499 2639 870744 SGTC_1781 st038725 66.3 µM -0.0797554759523803 0.482471252366828 no 1751 0.468215868253103 2552 4270275 YIL048W NEO1 SGTC_737 1950-0117 57.9 µM -0.0810118754583611 0.481955250771839 no 1752 0.467716254149197 2542 5393513 SGTC_181 1447-1644 8.07 µM -0.0814757673498011 0.481764738587932 no 1753 0.467531797824836 2549 534600 SGTC_82 0054-0107 293.755 µM -0.0823850082819906 0.481391341560655 no 1754 0.467170278589731 2639 3104697 SGTC_2084 5306078 60.6385 µM -0.0827112043279883 0.481257386931779 no 1755 0.467040587818225 2605 679340 SGTC_1414 3917-0015 5.4 µM -0.0831547126215308 0.481075260626689 no 1756 0.466864261030361 2561 6618702 SGTC_324 1315-0088 19.6 µM -0.0831715172645081 0.481068359891713 no 1757 0.466857580090798 2535 6787421 SGTC_1961 st076550 68.7 µM -0.0847638702676772 0.480414494846526 no 1758 0.466224558739074 2646 1579337 SGTC_179 1273-0063 6.77 µM -0.0851474671871627 0.480256986943914 no 1759 0.466072076970232 2567 3108139 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0854353540254076 0.480138780374476 no 1760 0.465957643726229 2622 688761 SGTC_890 0929-0006 47.2 µM -0.0854666005140662 0.480125950645757 no 1761 0.465945223608705 2557 1378169 SGTC_173 1273-0061 2.693 µM -0.0859162074462796 0.479941345469694 no 1762 0.465766513736152 2646 2847414 YPL266W DIM1 SGTC_1028 k015-0029 4.8 µM -0.0859323544025633 0.47993471573243 no 1763 0.465760095768244 2556 4588309 SGTC_2258 7960471 200 µM -0.0861030439647411 0.479864633083799 no 1764 0.46569225193975 2624 2974708 SGTC_3107 9121808 49.47 µM -0.0862273434102463 0.479813597933088 no 1765 0.465642847376994 2551 662681 SGTC_2937 9044753 11.33 µM -0.0871499832559907 0.479434788754595 no 1766 0.465276147797573 2568 6465530 YGL099W LSG1 SGTC_2821 7996764 71.43 µM -0.0892334370581718 0.478579451865308 no 1767 0.46444819621634 2635 2987135 SGTC_144 4161-2749 112.381 µM -0.089797546531406 0.478347880314364 no 1768 0.46422404894971 2552 797501 YMR168C CEP3 SGTC_2146 5545642 200 µM -0.0898909144965641 0.478309552704231 no 1769 0.464186950552214 2571 825326 SGTC_1660 st012960 28.1 µM -0.090484554620791 0.478065867756061 no 1770 0.463951083614496 2628 24207266 SGTC_80 0159-0065 512.242 µM -0.0913608566046238 0.477706167185587 no 1771 0.463602931767064 2549 1548079 SGTC_2108 5365811 200 µM -0.0923484786959537 0.477300794211221 no 1772 0.463210586234391 2641 780283 SGTC_1563 conessine 56.1 µM -0.0923499687319938 0.477300182638306 no 1773 0.463209994325416 2621 441082 An anti-amoebic, histamine inhibitor. SGTC_1716 st033144 30.6155 µM -0.0931055473575802 0.476990068586172 no 1774 0.462909855214005 2608 674617 SGTC_1206 3978-0017 132 µM -0.0950257556394577 0.476202015766555 no 1775 0.462147184721353 2837 3873677 SGTC_3183 9108214 49.47 µM -0.0950963124463907 0.476173061031144 no 1776 0.462119163522546 2563 4974831 SGTC_2245 6637752 200 µM -0.0955205422925573 0.475998970451329 no 1777 0.461950687235605 2698 681890 SGTC_934 2950-0684 338 µM -0.096841533024769 0.475456906915211 no 1778 0.461426120168915 2768 1121253 SGTC_1557 sumaresinolic acid 42.3 µM -0.0991616009162847 0.474504986410443 no 1779 0.460504981287609 2566 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1382 3002-2117 298 µM -0.0994479932775553 0.474387490019531 no 1780 0.460391289234451 2614 1497314 SGTC_1132 3456-3614 2.5 µM -0.0999334565609755 0.474188327148854 no 1781 0.460198577398476 2771 3125502 SGTC_3264 9137442 49.47 µM -0.100485007057725 0.473962059617252 no 1782 0.459979642612129 2645 17015726 SGTC_1938 st074717 56.4 µM -0.101047216338024 0.473731428081765 no 1783 0.459756489371187 2552 17250979 SGTC_875 0709-0210 25.7 µM -0.101188886136878 0.473673313167465 no 1784 0.459700259505965 2577 6251364 SGTC_779 1360-0071 233 µM -0.101202828459116 0.473667593863978 no 1785 0.459694725731392 2766 7566 SGTC_616 4092-0450 108 µM -0.101282043198871 0.473635099155228 no 1786 0.459663285169457 2637 787165 SGTC_1379 2144-0755 36.5 µM -0.102111487692372 0.473294862987747 no 1787 0.459334091409268 2629 5392327 SGTC_2388 9080168 200 µM -0.102284463659257 0.473223911102375 no 1788 0.459265443414825 2583 15943073 SGTC_3003 9075612 71.4286 µM -0.102585181321777 0.473100563706224 no 1789 0.459146102187905 2680 6501993 SGTC_1782 st039423 80.636 µM -0.103209186355714 0.472844619586301 no 1790 0.458898474596236 2628 2068169 SGTC_90 0870-0863 4.608 µM -0.104026053836038 0.472509587281327 no 1791 0.458574336381795 2589 1738164 SGTC_378 3970-0959 8.33 µM -0.105642802024732 0.471846547239342 no 1792 0.457932881819957 2692 6615653 SGTC_2274 7947094 46.08 µM -0.106199983442812 0.471618061122394 no 1793 0.457711842042041 2582 2971028 SGTC_3075 9116269 49.47 µM -0.1066033213525 0.471452668191513 no 1794 0.457551841772403 2716 17015205 YNL244C SUI1 SGTC_1516 st013856 110 µM -0.110095207608347 0.470020992535964 no 1795 0.456166934414481 2742 5281404 A mutagen and neurotoxin. SGTC_1753 st043925 64 µM -0.110161796823409 0.469993694620204 no 1796 0.456140529769219 2622 670181 SGTC_2729 fluphenazine 10.66 µM -0.110842671026011 0.46971458176085 no 1797 0.45587055361418 2618 3372 An atypical antipsychotic. SGTC_541 4513-1321 94 µM -0.11142811314077 0.469474601564423 no 1798 0.455638433904515 2620 747515 SGTC_2611 pyromycin 23.93 µM -0.111931225108689 0.469268378401983 no 1799 0.45543896905504 2654 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2701 st077767 14.721 µM -0.112249741927853 0.469137824156572 no 1800 0.45531269499742 2622 5721188 SGTC_3197 9113331 49.47 µM -0.112449827608331 0.469055814374872 no 1801 0.455233374553097 2723 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_53 0973-0023 39.979 µM -0.114912957429484 0.468046351815487 no 1802 0.45425705729507 2600 674768 SGTC_1418 3966-3099 2.4 µM -0.115504439930059 0.467803975351047 no 1803 0.454022650738637 2623 740335 SGTC_1658 st012944 20 µM -0.11576099979486 0.467698846491214 no 1804 0.453920980153497 2660 24207260 SGTC_2148 5546263 113.568 µM -0.115834489340903 0.46766873357476 no 1805 0.453891857973789 2612 792097 SGTC_2880 9042983 58.44 µM -0.117589891501807 0.466949499185862 no 1806 0.453196307393624 2742 6464714 SGTC_2119 5528445 120.635 µM -0.117738599007194 0.466888574738369 no 1807 0.453137390942709 2729 791935 SGTC_1827 berberine 7.24 µM -0.117838299308947 0.466847728641218 no 1808 0.45309789124138 2620 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2775 cyproheptadine 69.59 µM -0.118167557553491 0.466712837708316 no 1809 0.452967447569893 2602 2913 A selective serotonin reuptake inhibitor. SGTC_598 3937-0236 20.2 µM -0.11889833247999 0.466413466596473 no 1810 0.452677951439738 2678 1379313 SGTC_3289 9119912 71.43 µM -0.119840407144971 0.466027561958718 no 1811 0.452304786156259 2707 17014829 SGTC_1406 3909-7906 11.9 µM -0.121554378466746 0.465325545338837 no 1812 0.451625973089394 2658 X1406 SGTC_141 0443-0274 32.331 µM -0.121718465737919 0.465258343309755 no 1813 0.451560994216563 2662 1627241 SGTC_1049 3226-0134 66 µM -0.122161260824291 0.465077001296722 no 1814 0.451385652997681 2588 5702385 SGTC_1571 st070080 73.4 µM -0.12217319871106 0.465072112362536 no 1815 0.451380925877596 2740 4315245 SGTC_964 1287-0107 19.4 µM -0.12284128581667 0.464798518436521 no 1816 0.451116390234447 2737 51516812 YPR165W RHO1 SGTC_1821 st053465 65.6 µM -0.122881199992425 0.464782173374843 no 1817 0.4511005865111 2706 675086 SGTC_65 0798-0905 34.986 µM -0.123177198084751 0.464660962479368 no 1818 0.450983390671204 2941 3602145 SGTC_2745 rifampicin 24.3 µM -0.123201716789337 0.46465092224354 no 1819 0.450973683063045 2711 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_845 0330-0138 4.51 µM -0.125452806389255 0.46372921371336 no 1820 0.450082542414662 2616 9039800 SGTC_1810 st050138 53 µM -0.127337979598402 0.462957479180186 no 1821 0.449336450795017 2616 3444541 SGTC_3174 9107204 49.47 µM -0.128376782554196 0.462532283149565 no 1822 0.448925401974236 2728 3938802 SGTC_2899 9053889 58.44 µM -0.129310512508248 0.462150131431513 no 1823 0.448555976747584 2630 6470052 SGTC_454 lyso-paf C-16 6.67 µM -0.130085413378672 0.461833010896432 no 1824 0.44824942524572 2694 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1115 galangin 695.678 nM -0.1301262391988 0.461816304003448 no 1825 0.448233275368758 2639 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3045 9092950 49.47 µM -0.130994736358157 0.461460910395534 no 1826 0.447889735651443 2649 44120432 SGTC_3176 9106582 49.47 µM -0.130996143756826 0.461460334505491 no 1827 0.447889178977367 2632 17018027 SGTC_667 1498-1044 59 µM -0.131880516339008 0.461098476265922 no 1828 0.44753939985918 2680 6739982 SGTC_124 0136-0217 7.121 µM -0.132427456161821 0.460874701300955 no 1829 0.447323099520285 2665 3976905 SGTC_731 3966-0296 387 µM -0.132625440970558 0.460793700844468 no 1830 0.447244805585434 2652 660956 SGTC_2335 9018011 154.17 µM -0.135038537254325 0.459806575523284 no 1831 0.446290702525601 2759 6458208 SGTC_3231 9132313 49.47 µM -0.135540194345035 0.459601393551012 no 1832 0.446092393479985 2691 4905967 SGTC_1070 indatraline 8.81 µM -0.137838894196622 0.458661344397812 no 1833 0.445183872305042 2675 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1529 apigenin 74 µM -0.138275643042316 0.458482762715412 no 1834 0.445011287306488 2847 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1029 k015-0030 64.7 µM -0.13848001459628 0.45839920036525 no 1835 0.444930531736855 2761 2208316 SGTC_1469 k284-2957 126 µM -0.139409904174993 0.458019015345031 no 1836 0.44456312319311 2681 23884841 SGTC_2822 7994718 71.43 µM -0.139487662184756 0.457987225745926 no 1837 0.44453240239002 2630 1018011 SGTC_529 4076-0302 30.3 µM -0.140118596550115 0.457729292492349 no 1838 0.444283143809574 2680 5816522 SGTC_850 0388-0143 75.9 µM -0.140701458704603 0.457491027530225 no 1839 0.444052896340802 2678 67273 SGTC_2518 prenyletin 46.28 µM -0.141012925594111 0.457363710979303 no 1840 0.443929865615005 2696 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1656 st012921 11 µM -0.142720803513977 0.45666566954532 no 1841 0.443255343042664 2762 6732821 SGTC_215 1287-0124 461.5 µM -0.143950533550052 0.456163138701249 no 1842 0.442769765598353 2734 5560863 SGTC_1010 4112-3296 15.2 µM -0.144804856261269 0.455814059794779 no 1843 0.442432473949813 2800 704384 SGTC_376 3970-0862 59.1 µM -0.145925118379473 0.455356368948732 no 1844 0.441990251119129 2761 3135186 SGTC_48 0382-0018 55 µM -0.146592320428057 0.455083807043892 no 1845 0.441726907803481 2896 762596 SGTC_2207 7258803 200 µM -0.149363936576937 0.453951788626187 no 1846 0.440633233456548 2753 3666799 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.150768925048307 0.453378087779512 no 1847 0.440079000112964 2806 61125 An anti-inflammatory. SGTC_1274 0865-0114 173 µM -0.151094720649214 0.453245069071645 no 1848 0.439950498501024 2733 870624 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.151276842947734 0.453170712854597 no 1849 0.439878667846625 2670 442882 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.151842271064538 0.452939872431659 no 1850 0.43965567058823 2660 66535 A nucleotide analog. SGTC_1763 st044482 94.5 µM -0.152475362812762 0.452681426680246 no 1851 0.4394060104237 2803 88505 SGTC_1847 st056231 15 µM -0.152766234988595 0.452562691239911 no 1852 0.439291312855606 2671 5393180 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.152849714862078 0.452528615131486 no 1853 0.439258395768279 2779 5379071 SGTC_1421 4029-0249 71.4 µM -0.156251140431444 0.451140468692413 no 1854 0.437917533745452 2820 2894095 SGTC_1193 1488-0126 41.5 µM -0.156317627700251 0.451113340652784 no 1855 0.437891331121802 2700 1384710 SGTC_540 1187-0821 17.3 µM -0.156384910886576 0.451085888096487 no 1856 0.437864815104401 2695 847520 SGTC_2772 vinpocetine 57.06 µM -0.156710750468262 0.450952943937963 no 1857 0.437736407061286 2839 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2338 7999974 200 µM -0.157812680578794 0.450503391862468 no 1858 0.437302203108505 2790 315925 SGTC_162 k030-0015 37.8 µM -0.157826158826381 0.450497893562465 no 1859 0.437296892613361 2784 1809920 YMR134W ERG29 SGTC_3262 9137218 49.47 µM -0.159233905054308 0.449923671784141 no 1860 0.436742296133824 2634 17650664 SGTC_2373 9071805 200 µM -0.159597046723155 0.44977556271854 no 1861 0.436599252767557 2692 10149009 SGTC_3155 9099265 49.47 µM -0.159635000676828 0.449760083420553 no 1862 0.436584302988681 2804 25236499 SGTC_563 tetrahydrosecaminediol 614 µM -0.160862265638136 0.449259591917017 no 1863 0.436100941422795 2815 334274 A psychoactive constituent of the cannabis plant. SGTC_694 1315-0438 43.2 µM -0.160898095230043 0.449244981443042 no 1864 0.436086831272858 2736 6793154 SGTC_1874 staurosporine 7.6 µM -0.162878293658044 0.448437610146911 no 1865 0.435307130868616 2808 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1248 0469-0687 58.6 µM -0.163676284222103 0.448112311672524 no 1866 0.434992994094533 2798 4017482 SGTC_1935 st074532 41.6 µM -0.164660599087693 0.447711106734492 no 1867 0.434605565476569 2832 2829742 SGTC_2018 5133068 143 µM -0.165663863423168 0.447302233073487 no 1868 0.434210742918945 2689 785362 SGTC_1534 6-azauridine 81.6 µM -0.165776347502366 0.447256394423542 no 1869 0.434166480252272 2672 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1492 4158-0558 28.5 µM -0.165874397374396 0.447216438465782 no 1870 0.434127898142685 2805 3967268 SGTC_2214 7179297 48.276 µM -0.166306148940491 0.447040503285431 no 1871 0.433958013639325 2689 769744 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.167245012727063 0.446657960100838 no 1872 0.43358863405823 2821 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_855 0428-0020 25 µM -0.168259336993261 0.446244726078219 no 1873 0.433189631052018 2717 6812414 SGTC_2790 5423970 71.43 µM -0.168284128767184 0.446234626679679 no 1874 0.433179879605058 2848 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1892 st058411 7.36 µM -0.169396077589169 0.445781689233799 no 1875 0.43274255427658 2844 3934738 SGTC_837 0091-0265 12.5 µM -0.169523543820679 0.44572977208207 no 1876 0.432692427534936 2709 759367 SGTC_2751 anetholtrithion 17.25 µM -0.170184379686637 0.445460627764659 no 1877 0.432432567862928 2839 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1136 pergolide 1.05886 µM -0.170186216387277 0.445459879750732 no 1878 0.432431845660075 2720 47811 A dopamine receptor agonist. SGTC_3191 9110352 49.47 µM -0.170486551297516 0.4453375680955 no 1879 0.43231375502296 2666 17122424 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.171387066832936 0.444970863589283 no 1880 0.43195971174701 2927 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2872 9044037 25.97 µM -0.171497336154506 0.444925963365832 no 1881 0.431916362427593 2688 6465195 SGTC_567 1080-0542 68.4 µM -0.172297608129952 0.444600124307021 no 1882 0.431601782335163 2713 5950415 SGTC_1997 st073024 93.8 µM -0.172417261085126 0.444551409573331 no 1883 0.431554751500836 2713 686268 SGTC_2961 9083290 32.55 µM -0.172439497283853 0.444542356562832 no 1884 0.43154601143932 2703 17741490 SGTC_1345 1488-0192 31.4 µM -0.174201600285091 0.443825044975779 no 1885 0.430853513960902 2788 658348 SGTC_2466 5983409 37.09 µM -0.17473807111838 0.443606696472245 no 1886 0.430642725771165 2754 2879657 SGTC_2828 7998861 71.43 µM -0.174782187312345 0.443588741541367 no 1887 0.43062539267338 2775 2988188 SGTC_134 0269-0018 6.916 µM -0.174882652176888 0.443547853593678 no 1888 0.430585920879465 2804 4378915 SGTC_750 4073-0104 132 µM -0.175450737084768 0.443316661436762 no 1889 0.430362738192183 2790 22330957 SGTC_1696 st025591 34.7925 µM -0.176434614227805 0.442916300997696 no 1890 0.429976256480256 2733 2787147 SGTC_508 roscovitine 141 µM -0.176991021987509 0.442689912672437 no 1891 0.429757720832145 2721 160355 A CDKinase inhibitor. SGTC_2104 5389443 200 µM -0.177415919638812 0.442517045099267 no 1892 0.429590851803697 2883 2244536 SGTC_2213 7173844 200 µM -0.178506188115965 0.442073524740267 no 1893 0.429162730915527 2741 892728 SGTC_3142 9086498 49.47 µM -0.178874741320411 0.441923613978875 no 1894 0.429018028199638 2848 25236367 SGTC_1424 4048-1941 275 µM -0.179925687488235 0.441496182395034 no 1895 0.428605454294624 2836 X1424 SGTC_1663 st014140 55.4 µM -0.180113520836535 0.441419795629038 no 1896 0.428531724052131 2728 4207120 SGTC_1943 st076331 65.2 µM -0.180687394624332 0.441186430118971 no 1897 0.428306476781083 2785 24208415 SGTC_756 0508-1999 28.3 µM -0.182306694966594 0.440528052740725 no 1898 0.42767102245326 2741 6753853 SGTC_1143 3454-2408 5.08 µM -0.182532245289615 0.440436361178557 no 1899 0.427582525658921 2698 X1143 SGTC_2455 5377712 9.75 µM -0.183620074696823 0.439994177627419 no 1900 0.427155756780122 2809 2243908 SGTC_266 formosanin C 406 nM -0.183976711366009 0.43984922734628 no 1901 0.427015862350056 2841 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2332 7982454 138.89 µM -0.184278834457701 0.439726439698628 no 1902 0.426897358616432 2784 2981748 SGTC_537 1334-0398 209 µM -0.184718772566191 0.439547652198977 no 1903 0.426724810590443 2835 5846986 SGTC_2372 9071633 200 µM -0.18493548437465 0.43945958669932 no 1904 0.426639819253715 2745 21321366 SGTC_1561 5-methoxyflavone 52.9 µM -0.185183807516019 0.439358678938965 no 1905 0.426542434582802 2727 94525 SGTC_413 propylparaben 100 µM -0.18579058989434 0.439112125473334 no 1906 0.426304492116016 2719 7175 A pharmaceutical preservative. SGTC_2317 5986382 200 µM -0.186660321874682 0.438758769092843 no 1907 0.425963483899696 2798 877883 SGTC_515 4092-1064 102 µM -0.186682257847395 0.438749857533518 no 1908 0.425954883864805 2937 717353 SGTC_1956 st077085 54 µM -0.188474799643695 0.438021737020431 no 1909 0.425252234234836 2782 24208685 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.189437307489486 0.437630858087745 no 1910 0.424875043324747 2887 5377381 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.190466540827872 0.43721294896006 no 1911 0.424471779891095 2730 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_921 1561-0023 372 µM -0.191510606476073 0.436789088899858 no 1912 0.42406278578178 2710 24050882 SGTC_1405 3909-7894 12 µM -0.191596200048213 0.436754343629024 no 1913 0.424029259646179 2843 7104060 SGTC_3345 9148410 3.559 µM -0.192506997902669 0.436384650831392 no 1914 0.423672543447593 2864 4903596 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.194846094877119 0.435435466841252 no 1915 0.422756717648819 2695 4000243 SGTC_1704 st028805 70.8 µM -0.195264461673835 0.435265736497367 no 1916 0.42259295850209 2802 2876101 SGTC_332 4112-0506 40.9 µM -0.195363068053654 0.435225733875753 no 1917 0.422554363464955 2758 2790355 SGTC_145 3737-0113 38.366 µM -0.195407137724827 0.435207855912369 no 1918 0.422537114612536 2879 6849351 SGTC_1992 st073643 23.3 µM -0.195867909001768 0.435020940467985 no 1919 0.422356777812757 2733 3161292 SGTC_2371 9071574 200 µM -0.196093263129145 0.434929529101957 no 1920 0.42226858457117 2774 45596039 SGTC_2886 9058944 51.95 µM -0.19727908524413 0.434448576378647 no 1921 0.421804572639892 2745 4949929 SGTC_446 go6976 132 µM -0.198111713156671 0.434110932165163 no 1922 0.421478830344977 2893 3501 A protein kinase C inhibitor. SGTC_1689 st020265 53.493 µM -0.19826984303894 0.434046813339453 no 1923 0.421416972532228 2887 5758320 YPR016C TIF6 SGTC_774 k060-0086 136 µM -0.198991436853905 0.433754242065429 no 1924 0.42113472152324 2737 5911235 SGTC_456 gingerol 170 µM -0.202123463109541 0.432484780050765 no 1925 0.419910102749747 2941 442793 A herb. SGTC_1705 st027868 56.3335 µM -0.202293611448063 0.432415835948627 no 1926 0.419843597029981 2841 292948 SGTC_1735 st034310 56.75 µM -0.202981906196492 0.432136959955312 no 1927 0.419574587292753 2969 871153 SGTC_2443 5493264 126.67 µM -0.203014061262413 0.432123932531043 no 1928 0.419562020882696 2937 5340055 SGTC_1587 estradiol valerate 56.1 µM -0.204442222081445 0.431545396724353 no 1929 0.419003969209487 2904 13791 A steroid. SGTC_3265 9137266 49.47 µM -0.204694709694956 0.431443131374987 no 1930 0.418905326973403 2735 17224265 SGTC_310 1273-0058 1.06 µM -0.20632569850151 0.430782641105104 no 1931 0.418268252935218 2861 2734232 SGTC_2120 5538279 151.968 µM -0.20678145180483 0.430598112359893 no 1932 0.418090271200615 2796 2058197 SGTC_2644 guaiazulene 100 µM -0.207517739293019 0.430300030904321 no 1933 0.417802770119934 2875 3515 A coloring agent. SGTC_2624 nerol 100 µM -0.208337837172374 0.429968066088117 no 1934 0.417482594980878 2749 637566 A natural product oil. SGTC_671 0560-0003 407 µM -0.208614072044105 0.429856260984813 no 1935 0.41737476218509 2835 3238678 SGTC_3330 9141424 71.43 µM -0.209128165350942 0.429648198489298 no 1936 0.417174094011952 2901 27261020 SGTC_1559 coumarin 343 70.1 µM -0.20934025488578 0.429562367858571 no 1937 0.417091314506893 2925 108770 A hepatotoxic, DNA x-linker. SGTC_933 2914-0560 114 µM -0.210255959061879 0.429191829300819 no 1938 0.416733953258216 2981 463887 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.210293649460008 0.429176579262529 no 1939 0.41671924573582 2768 15053 SGTC_644 1498-1197 63.3 µM -0.211047753573931 0.42887148091557 no 1940 0.416425004249416 2891 6741615 SGTC_1107 amlodipine 47 µM -0.211201059759848 0.428809460900297 no 1941 0.416365191918334 2831 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_986 1493-0483 84 µM -0.211973797472923 0.428496876660214 no 1942 0.416063738198796 2810 40079 SGTC_2299 7976368 114.88 µM -0.212396204320576 0.428326025568231 no 1943 0.415898973371853 2929 2979718 SGTC_2413 inermin 26.06 µM -0.212695193601555 0.428205101353742 no 1944 0.41578235797084 3087 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_773 4358-1457 44.6 µM -0.212793013152703 0.42816554035372 no 1945 0.415744206820659 2906 1186886 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.214214199890887 0.427590853781739 no 1946 0.415190011591342 2911 521171 SGTC_1320 1313-0481 95.3 µM -0.214753710380937 0.427372731589889 no 1947 0.414979672278909 2935 6813365 YLR208W SEC13 SGTC_1646 st011709 75.6 µM -0.215672404525939 0.427001357901226 no 1948 0.414621556493396 2853 5757843 SGTC_2265 7929201 200 µM -0.215793404021904 0.426952449778172 no 1949 0.414574395011249 2753 1265108 SGTC_1519 esterone 74 µM -0.217532429061265 0.426249658440918 no 1950 0.413896718636936 2783 698 A steroid. SGTC_2861 9024595 19.48 µM -0.21863298696427 0.425805011347961 no 1951 0.413467977254192 2838 16482810 SGTC_958 1222-0007 33 µM -0.219701286302344 0.42537348756286 no 1952 0.413051901408931 2957 7312461 SGTC_534 k292-0788 63.4 µM -0.219822159064008 0.42532466840998 no 1953 0.413004830635129 2843 4146317 SGTC_2695 st077686 51.995 µM -0.220743512319924 0.424952581841572 no 1954 0.412646074564365 2847 2876092 SGTC_2328 6201408 200 µM -0.222432537363046 0.42427064647298 no 1955 0.411988592509121 2918 2890418 SGTC_482 fipronil 114 µM -0.223853029323072 0.423697305361377 no 1956 0.411435832693517 2779 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1241 0364-0022 50.8 µM -0.224445603129142 0.423458177492845 no 1957 0.411205294758177 2862 4563895 SGTC_3324 9138759 60.749 µM -0.225282017002368 0.423120698136513 no 1958 0.410879944237327 2931 45595710 SGTC_1147 3809-1045 12.3 µM -0.225619906075863 0.422984381387181 no 1959 0.410748528607039 2810 325925 SGTC_1555 citronellol 128 µM -0.226018673384383 0.422823516005357 no 1960 0.41059344841598 2870 8842 A terpine precursor. SGTC_902 1120-0002 2.07 µM -0.226589112307359 0.422593419530715 no 1961 0.410371629615889 2787 3280475 SGTC_518 1021-0119 62.6 µM -0.227420831541345 0.422257978437383 no 1962 0.410048261699331 2853 1097762 SGTC_1914 st062367 72.6 µM -0.22782806155673 0.422093758845413 no 1963 0.409889955173565 2822 978205 SGTC_3094 9117742 49.47 µM -0.228289879542762 0.421907542496595 no 1964 0.409710445902644 2771 17149698 SGTC_1187 1391-0724 117 µM -0.228339663178911 0.421887469554142 no 1965 0.409691096065794 2831 6997986 SGTC_2436 5633522 8.09 µM -0.228644219604753 0.421764675719911 no 1966 0.409572726273646 2945 5724242 SGTC_709 3807-1509 243 µM -0.228893452260314 0.421664193486183 no 1967 0.409475864912063 2773 1886677 YPL242C IQG1 SGTC_2006 4011487 200 µM -0.229067343732749 0.421594089306697 no 1968 0.409408287293813 2957 45595294 SGTC_2576 guaiol 23.12 µM -0.231124883328715 0.420764783449839 no 1969 0.408608892154314 2958 227829 SGTC_311 1315-0136 58 µM -0.233908723142482 0.419643297329498 no 1970 0.407527920483219 2982 6759207 SGTC_2831 7999036 19.48 µM -0.234207009843257 0.419523169325025 no 1971 0.407412136640493 3107 2988270 SGTC_1643 st009866 20.2 µM -0.234257551831578 0.419502815462007 no 1972 0.407392518914817 2914 3156273 YOR207C RET1 SGTC_1499 4480-0877 67.3 µM -0.235000736976581 0.419203550813041 no 1973 0.407104080606596 2810 2861909 SGTC_898 1000-0849 28.3 µM -0.235509311409717 0.4189987857677 no 1974 0.406906726309465 2814 6751807 SGTC_1588 farnesol 29.9 µM -0.236912066372055 0.418434114698716 no 1975 0.406362504415607 2833 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_741 4582-0002 126 µM -0.238240925212553 0.417899345073083 no 1976 0.40584711851587 2815 2912688 SGTC_747 3448-8087 38.7 µM -0.239856114282115 0.417249552657586 no 1977 0.405220901759938 2891 5168703 SGTC_2946 9065502 71.43 µM -0.240049823387991 0.417171638400981 no 1978 0.40514581604467 2841 16489101 SGTC_587 k089-0003 57 µM -0.240084359881628 0.417157747370657 no 1979 0.405132429341493 2813 9659696 SGTC_1688 st021091 57.6 µM -0.24034000645413 0.417054926185942 no 1980 0.405033341530948 2919 3656366 SGTC_1470 k295-0292 231 µM -0.241060462241033 0.416765189035869 no 1981 0.404754127899173 2935 5045612 SGTC_2403 6032726 181.2 µM -0.241332449467993 0.416655818908586 no 1982 0.404648731475534 2907 2881040 SGTC_402 epigallocatechin gallate 10 µM -0.241374959617412 0.41663872552516 no 1983 0.404632259202937 2855 65064 An antioxidant. SGTC_749 1000-0129 128 µM -0.242375410879022 0.416236488414549 no 1984 0.404244642852191 2991 708470 SGTC_640 3381-0960 37.1 µM -0.243717979043759 0.415696839162376 no 1985 0.403724623957045 2888 1745025 SGTC_2940 9060638 45.86 µM -0.243995876516056 0.415585157271717 no 1986 0.403617006744359 2951 4027022 SGTC_2358 9037157 4 µM -0.244909655403603 0.415217974436522 no 1987 0.403263192698288 2938 2388925 SGTC_1547 harmine 94.2 µM -0.245048780029669 0.415162076616652 no 1988 0.403209330754341 2862 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2459 5811157 9.22 µM -0.245798003246244 0.414861081500789 no 1989 0.402919301416507 2823 2870684 YBR192W RIM2 SGTC_1286 0929-0070 131 µM -0.245864988719844 0.414834172992801 no 1990 0.402893373488521 2938 1420408 SGTC_592 k241-0073 46.5 µM -0.247196247035949 0.414299480759965 no 1991 0.402378174814566 2961 4230158 SGTC_1834 st055981 52.8 µM -0.247460005393859 0.414193562550686 no 1992 0.40227612008476 2993 471719 YDL150W RPC53 SGTC_329 k048-0121 21.3 µM -0.248879530740315 0.413623626993118 no 1993 0.401726984651024 2922 6832902 SGTC_2720 fluspirilene 36.88 µM -0.249193983847797 0.413497399498894 no 1994 0.401605366433569 2940 3396 An atypical antipsychotic. SGTC_2926 9010726 65.15 µM -0.249970649194176 0.413185669500527 no 1995 0.401305023379527 2962 2994293 SGTC_2885 9057732 51.95 µM -0.250710877544234 0.41288861514113 no 1996 0.401018825082662 3009 6471414 SGTC_317 4495-0002 170 µM -0.251326423154898 0.412641634059911 no 1997 0.400780873952555 2893 15991618 SGTC_1761 st044296 37 µM -0.251686859964603 0.412497028699236 no 1998 0.400641557174004 2822 1826700 SGTC_2495 cafestol 54.53 µM -0.252962423523614 0.411985374792287 no 1999 0.400148625334497 3064 16667697 An anti-infammatory. SGTC_2345 9052315 157.45 µM -0.253737089238517 0.41167471392259 no 2000 0.399849339227771 2942 6469265 SGTC_2605 digitonin 300 nM -0.253847055895673 0.411630618948136 no 2001 0.399806859224185 2950 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_995 3931-2021 34.6 µM -0.254676087211525 0.411298225827938 no 2002 0.399486643503279 2959 730143 SGTC_636 0kpi-0074 126 µM -0.257052609298091 0.410345732933264 no 2003 0.398569080400653 2950 616434 SGTC_719 2810-4230 27.3 µM -0.257775378259742 0.410056156922071 no 2004 0.398290133880237 2839 721079 SGTC_1784 st039334 36.3 µM -0.257894093133998 0.410008598718246 no 2005 0.398244321851437 3096 3496984 SGTC_510 ag-490 170 µM -0.257904114691826 0.410004584056215 no 2006 0.398240454599936 2930 5328779 SGTC_647 0140-0236 81 µM -0.258249476947444 0.409866236808866 no 2007 0.398107187747373 2898 990837 SGTC_2801 7907800 81.82 µM -0.258466352000579 0.409779365456292 no 2008 0.398023507039908 2964 6620925 SGTC_420 mitomycin C 81.9 mM -0.258569067483185 0.409738223343982 no 2009 0.397983876159427 2868 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1940 st075990 51.1 µM -0.258945254013189 0.409587552421019 no 2010 0.397838740492642 3114 1084979 SGTC_2144 5628481 200 µM -0.259309127533147 0.409441825830945 no 2011 0.397698368730677 2865 2818399 SGTC_1756 st041558 35.5 µM -0.259424631401787 0.409395570656025 no 2012 0.397653813484721 3058 3955792 SGTC_2000 st075254 36.4 µM -0.259687566276689 0.409290279332347 no 2013 0.397552392181761 2874 17234175 SGTC_1497 4476-2978 41.3 µM -0.260936366185056 0.408790291373082 no 2014 0.397070789943199 2951 1528379 SGTC_70 0141-0289 43.283 µM -0.261817687773471 0.408437521725442 no 2015 0.396731000871604 2956 352408 SGTC_2995 9067767 71.4286 µM -0.262668906169705 0.408096872008711 no 2016 0.396402892355401 2946 11673567 SGTC_3041 9091929 49.47 µM -0.262817788411806 0.408037297843399 no 2017 0.396345512109004 3042 25236887 SGTC_1770 st043884 66.3 µM -0.263432855573682 0.407791205661017 no 2018 0.39610848477858 2851 670149 SGTC_1777 st045864 34.765 µM -0.26397862051159 0.407572872184116 no 2019 0.395898196474973 2888 4691462 SGTC_2271 7849410 118.62 µM -0.264130835551312 0.407511983614701 no 2020 0.395839552005574 2878 972430 SGTC_1627 st003713 25.6 µM -0.26418830462128 0.407488995603591 no 2021 0.39581741129067 2942 16195070 YER133W GLC7 SGTC_99 0109-0120 622.8 µM -0.264976775847433 0.407173634058336 no 2022 0.395513676355808 3055 759414 SGTC_976 1348-1067 47.6 µM -0.265409061147969 0.407000760233356 no 2023 0.395347178304463 2893 5310671 YGL099W LSG1 SGTC_2830 7992007 71.43 µM -0.26817712587263 0.405894223173388 no 2024 0.394281490609695 2749 1952075 SGTC_1062 mesoridazine 14.2 µM -0.268805708873777 0.405643050770753 no 2025 0.394039599972278 2863 4078 A neuroleptic. SGTC_2340 7987427 183.45 µM -0.269659091412987 0.405302114005933 no 2026 0.393711267639118 3020 2239331 SGTC_2915 7971052 15.16 µM -0.2704996960647 0.404966352400372 no 2027 0.393387925357874 2905 5741558 SGTC_397 arbidol 50 µM -0.271335612279938 0.404632532851969 no 2028 0.39306645940436 3034 131410 A RNA synthesis inhibitor. SGTC_813 k007-0158 173 µM -0.271646408344012 0.404508435465541 no 2029 0.392946956015063 2957 6523916 SGTC_1723 st034307 2.5525 µM -0.272729280341065 0.404076131925725 no 2030 0.392530662591247 2955 867466 SGTC_693 4161-2696 114 µM -0.273715119320151 0.403682667684061 no 2031 0.392151778898711 2994 805759 SGTC_877 0771-0151 33.1 µM -0.274854938605833 0.403227868913019 no 2032 0.391713843991495 2984 6166523 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.275453498238267 0.402989090273818 no 2033 0.391483923700594 2836 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1920 st075728 45.7 µM -0.277307786697318 0.402249603691299 no 2034 0.390771890510136 3099 3400306 SGTC_2842 9000675 19.48 µM -0.277328022172922 0.40224153574774 no 2035 0.39076412225062 2954 2989072 SGTC_2384 9036245 200 µM -0.278919850197997 0.401607000003646 no 2036 0.390153167289198 2943 6462766 SGTC_1672 st016598 6.51 µM -0.279376456639816 0.401425034973951 no 2037 0.38997796846711 2937 4665860 YNL267W PIK1 SGTC_20 0481-0013 4.944 µM -0.279650325688633 0.401315903994483 no 2038 0.389872896274338 2919 182045 SGTC_245 methotrexate 289.6 µM -0.280321267429955 0.4010485805551 no 2039 0.389615517781591 2981 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1636 st007707 68.9 µM -0.280540164039828 0.400961375554608 no 2040 0.389531557798874 3099 403051 SGTC_2178 5812956 200 µM -0.281448071831468 0.400599731953455 no 2041 0.38918337577143 2851 5403383 SGTC_1947 st076332 61.6 µM -0.282296350483522 0.400261917180976 no 2042 0.388858141860816 2993 24208416 SGTC_1853 st056710 91.2 µM -0.282972389710032 0.399992747691103 no 2043 0.388599001083074 3067 269167 SGTC_2107 5363541 170.161 µM -0.282996114366136 0.399983302424468 no 2044 0.388589907797678 2968 244052 SGTC_1182 1222-0449 220 µM -0.283482056932013 0.399789851716897 no 2045 0.388403667137812 2975 658318 SGTC_2739 tacrine 100.86 µM -0.28393336528653 0.399610210698807 no 2046 0.388230723241159 3003 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1412 3909-8563 178 µM -0.286444910562744 0.398610891921164 no 2047 0.387268690683575 3008 23767530 SGTC_502 l-744,832 89.3 µM -0.286469976078709 0.398600921940481 no 2048 0.387259092963588 3023 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2015 5119600 184 µM -0.286761485162991 0.39848497706695 no 2049 0.387147477640492 3101 2828786 SGTC_2954 9074818 52.69 µM -0.287218700828079 0.398303142081165 no 2050 0.386972434056115 3083 16648742 SGTC_1700 st030840 7.9285 µM -0.287638678153951 0.398136136263579 no 2051 0.386811667305902 3024 5499307 SGTC_3346 9158254 43.5805 µM -0.287773118093415 0.398082679575712 no 2052 0.386760207981572 2998 17639500 SGTC_335 4077-0256 27.6 µM -0.288450186178652 0.397813489440158 no 2053 0.386501078173886 2998 3121989 SGTC_2298 7976326 193.81 µM -0.289652055150625 0.39733576776495 no 2054 0.386041219488194 2900 2235818 SGTC_152 4469-0003 551.229 µM -0.290248573588554 0.397098719354685 no 2055 0.385813039209609 2893 697280 SGTC_2125 5246583 200 µM -0.291135233003173 0.396746443080317 no 2056 0.385473947201957 3063 835267 SGTC_2051 5263410 176 µM -0.292117759705514 0.396356176447936 no 2057 0.385098294164507 2975 227584 SGTC_2812 7970281 58.44 µM -0.292334780983248 0.396269988030632 no 2058 0.385015334147305 3068 2233435 SGTC_588 3970-1144 52.9 µM -0.292395779649719 0.39624576376774 no 2059 0.38499201733308 3037 1888707 SGTC_1441 4106-0040 13 µM -0.292799200430984 0.396085564271988 no 2060 0.384837819724187 2922 2904180 SGTC_1622 st003707 19.4 µM -0.294650299915051 0.395350712979523 no 2061 0.384130516629662 3053 10140899 SGTC_561 1550-0330 72.9 µM -0.295732799103397 0.394921153575551 no 2062 0.383717073443805 2935 6812934 SGTC_136 0097-0015 404.482 µM -0.295972436712891 0.394826077364698 no 2063 0.383625565581025 2960 4861337 SGTC_1014 4130-3005 69.3 µM -0.296227658173272 0.394724825149002 no 2064 0.383528114015999 2915 743608 SGTC_148 3253-0744 288.01 µM -0.296400438928126 0.394656283090709 no 2065 0.383462145081898 2909 6893655 SGTC_100 0086-0128 49.5915 µM -0.297249355202363 0.394319565742059 no 2066 0.383138071856625 2969 93297 SGTC_2687 chenodiol 100 µM -0.297651154893852 0.394160221913586 no 2067 0.382984713586613 3024 5702181 A cholesterol synthesis inhibitor. SGTC_2050 5263056 171 µM -0.297736792119228 0.394126262595356 no 2068 0.382952030076262 3094 763468 YGL055W OLE1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.297895757117326 0.394063227388527 no 2069 0.382891363176578 2903 2333 A French combination drug. SGTC_2525 harmine 47.85 µM -0.297943891208896 0.394044141077343 no 2070 0.382872994000506 2976 5280953 A monoamine oxidase inhibitor SGTC_1282 0886-0010 32.4 µM -0.298488250937959 0.393828307230947 no 2071 0.382665271026137 3097 2836211 YNL267W PIK1 SGTC_2236 dapsone 200 µM -0.300713769718193 0.39294624845807 no 2072 0.381816383904203 2966 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2225 6654152 15.4 µM -0.300748037536441 0.392932671085843 no 2073 0.381803317444763 2997 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1372 2752-0194 270 µM -0.301120760663999 0.392785001567539 no 2074 0.381661205290601 2899 823334 SGTC_174 3553-0389 74.3 µM -0.301279279908138 0.39272220235821 no 2075 0.381600769787025 3074 738071 SGTC_1662 st014054 52 µM -0.301474648161785 0.392644808834801 no 2076 0.381526289559636 2952 2838777 SGTC_2202 7226349 200 µM -0.301489233595907 0.392639031105531 no 2077 0.381520729331415 2926 844334 SGTC_1386 3228-0095 33.8 µM -0.301542377907188 0.392617979245111 no 2078 0.381500469976788 3067 870181 SGTC_710 3448-4187 58 µM -0.30276438165129 0.392133998183936 no 2079 0.381034714726844 2979 3946412 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.30288547329504 0.392086048269122 no 2080 0.380988571155911 3007 676296 Flavone; oxidizing agent. SGTC_1239 0337-0584 35.4 µM -0.30435421781302 0.391504584946118 no 2081 0.380429021583366 3114 914301 YML130C ERO1 SGTC_2862 9027634 71.43 µM -0.30435824924582 0.391502989269454 no 2082 0.380427486066639 2899 5012562 SGTC_2608 thymoquinone 42.66 µM -0.30452653820278 0.39143638064487 no 2083 0.380363388822874 3019 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_566 0958-0068 16.5 µM -0.30503164027745 0.391236480799865 no 2084 0.380171027239546 3115 6815365 SGTC_696 1560-0013 611 µM -0.30611265907051 0.390808752006694 no 2085 0.379759434873942 3148 1650269 SGTC_2191 5911152 200 µM -0.306559431986267 0.390632015046146 no 2086 0.379589368121746 2992 2875902 SGTC_3273 9137859 49.47 µM -0.308005124293656 0.390060274904471 no 2087 0.37903921657491 3018 2377234 SGTC_474 dl-dihydrosphingosine 5 µM -0.308273059762783 0.389954338280256 no 2088 0.378937281837545 3090 3058739 A sphingolipid protein kinase C inhibitor. SGTC_358 0075-0058 9.45 µM -0.309285584347705 0.389554079046932 no 2089 0.378552147896202 2976 1069125 SGTC_1531 st059297 52.4 µM -0.313334970813206 0.387954498365351 no 2090 0.377013091983159 3064 7566702 SGTC_1301 naphtanilide LB 4.81 µM -0.314127529205944 0.387641644903836 no 2091 0.376712090865074 3077 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2617 dihydrotanshinone i 20.83 µM -0.31490763235107 0.387333779233007 no 2092 0.376415893223976 2960 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2262 9014885 67.46 µM -0.315721989461142 0.387012470903561 no 2093 0.376106767302461 2942 6457424 SGTC_1388 3346-4487 254 µM -0.316254086910617 0.386802571216279 no 2094 0.375904828663384 3042 3345614 SGTC_1976 st070609 63.5 µM -0.318281417569705 0.386003141726935 no 2095 0.375135739307743 2900 682556 SGTC_2770 toltrazuril 17.5 µM -0.319040913107447 0.385703777171874 no 2096 0.374847744220209 3013 68591 Kills coccidiodes. SGTC_2176 5809774 33.9695 µM -0.319104051255854 0.385678893552196 no 2097 0.374823805840903 3086 2870539 SGTC_175 3793-3120 23.7 µM -0.319899229922092 0.385365542922205 no 2098 0.374522360828097 2967 5322297 SGTC_3012 9080433 71.4286 µM -0.321845275039516 0.384598994201044 no 2099 0.373784956561919 3077 17688859 SGTC_521 r062-0005 13.8 µM -0.322091112487506 0.384502190656267 no 2100 0.373691835513507 2950 2832033 SGTC_1152 3909-8331 15.9 µM -0.323129409721244 0.384093419301653 no 2101 0.373298619107651 3008 16001939 SGTC_2367 9070478 135.38 µM -0.323418217563811 0.383979740291123 no 2102 0.373189267325273 2934 572802 SGTC_1488 4013-0813 75.9 µM -0.32471219353885 0.383470535011999 no 2103 0.37269945261167 2983 2910057 SGTC_13 0199-0087 65 µM -0.324749743459416 0.383455761371531 no 2104 0.372685241735078 2975 4589825 SGTC_469 w7 172 µM -0.325789505980841 0.383046744592685 no 2105 0.372291809483826 2998 45115570 A P450 inhibitor. SGTC_1615 st002656 86.5 µM -0.326734607442594 0.382675078207004 no 2106 0.371934311308771 2976 1584458 SGTC_113 0099-0221 2.5 µM -0.327980102215942 0.38218544551538 no 2107 0.371463353680637 3168 89219 SGTC_2497 7-hydroxyflavone 100 µM -0.329452428302225 0.381606883171952 no 2108 0.370906872698835 3147 5281894 SGTC_608 k048-0125 159 µM -0.329604122928231 0.381547288554986 no 2109 0.370849553450791 3107 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2993 9054257 71.4286 µM -0.330030787606568 0.381379684505682 no 2110 0.370688349539846 2956 6470217 YGL055W OLE1 SGTC_1620 st003704 16.5 µM -0.330187968469257 0.381317945723452 no 2111 0.370628968647371 3096 2834414 SGTC_3226 9131256 49.47 µM -0.33067510198249 0.381126624636766 no 2112 0.370444955501825 2990 17178073 SGTC_1878 temozolomide 1 mM -0.331232001075882 0.380907938798555 no 2113 0.37023462494121 3097 5394 DNA alkylating agent. SGTC_1769 st044406 64.4 µM -0.332295134559142 0.380490568051147 no 2114 0.369833206717747 2973 670903 SGTC_2833 9001315 45.46 µM -0.334427291079549 0.379653933998089 no 2115 0.369028574221534 2963 2989378 SGTC_2447 5741742 33.78 µM -0.335098757851391 0.379390574448734 no 2116 0.368775294919582 3083 1776504 SGTC_1881 5652484 16 µM -0.335563868101427 0.379208183882241 no 2117 0.368599887323113 3135 2255129 SGTC_1026 k007-1105 30.6 µM -0.335655559524142 0.379172230738736 no 2118 0.368565310854078 2980 7066794 SGTC_2359 9039622 200 µM -0.335767014898404 0.379128529355282 no 2119 0.368523282910846 2963 6463596 SGTC_2216 7189485 200 µM -0.336054085671261 0.379015976712179 no 2120 0.368415040604047 3105 731273 SGTC_2412 st077135 33.4 µM -0.336596367338131 0.378803390813137 no 2121 0.368210597508789 3252 13258915 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.337750366428181 0.378351120820408 no 2122 0.367775657923741 3198 551469 SGTC_3070 9117005 49.47 µM -0.339778074371036 0.377556834790435 no 2123 0.367011830362454 3068 8779016 SGTC_133 0724-0033 378.92 µM -0.340145646748885 0.377412906054595 no 2124 0.366873423908558 2925 280309 SGTC_1300 1094-0077 113 µM -0.340387118433979 0.377318363289006 no 2125 0.366782509083547 3007 5532636 SGTC_2082 5219693 150 µM -0.340932795050159 0.377104743065142 no 2126 0.366577087704918 2992 2834649 SGTC_2681 menadione 3.18 µM -0.341055695957481 0.377056635287851 no 2127 0.366530826609892 3088 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2323 6148992 148.28 µM -0.342940812064102 0.376318973474673 no 2128 0.365821493940219 3023 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.343286557791741 0.376183729181372 no 2129 0.365691446205178 3036 688664 SGTC_2072 5231554 129 µM -0.344278479169836 0.375795806772054 no 2130 0.36531843365382 3132 789545 SGTC_2420 aureobasidin a 50 nM -0.344308552297963 0.375784047676855 no 2131 0.36530712662588 3272 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_605 1315-0399 119 µM -0.345557536153123 0.375295776146807 no 2132 0.364837631653159 3150 24020461 SGTC_1856 st057054 55.7 µM -0.345738662476632 0.375224984087706 no 2133 0.36476956279117 3232 1266018 SGTC_1855 st056195 39.6 µM -0.346138492929765 0.375068727805715 no 2134 0.36461931809072 3199 4028379 SGTC_61 0978-8327 98.565 µM -0.346812828262774 0.374805239730508 no 2135 0.364365969524572 3120 6150059 YHR072W ERG7 SGTC_2031 5180455 200 µM -0.347013683919473 0.374726769189958 no 2136 0.36429051926799 3011 29949 SGTC_556 4058-0063 51.5 µM -0.348406953691507 0.374182587745773 no 2137 0.363767290501507 3065 6615692 SGTC_1404 3909-7820 48.3 µM -0.350421863323027 0.373396050532311 no 2138 0.363011060375495 3123 23741373 SGTC_2074 5212007 75.395 µM -0.35065048800723 0.373306838172233 no 2139 0.362925287279994 3128 758611 SGTC_2089 5281248 129.67 µM -0.351293706329385 0.373055882362451 no 2140 0.362684008036704 3040 2737878 SGTC_863 0466-0191 129 µM -0.351464421608847 0.372989285725202 no 2141 0.362619979749143 3149 765160 YPR165W RHO1 SGTC_2709 st078560 56 µM -0.351598058540993 0.372937156131176 no 2142 0.362569860706884 3197 17250903 SGTC_2869 9037858 32.47 µM -0.353224489523173 0.372302898578204 no 2143 0.361960074857522 2981 27187042 SGTC_949 1165-0505 146 µM -0.35347476430942 0.372205329882587 no 2144 0.361866272222802 3028 6244267 SGTC_372 0155-0182 15.9 µM -0.353663211479335 0.372131869867095 no 2145 0.36179564796695 2990 771486 SGTC_1564 D-Arginine 115 µM -0.354225607955996 0.37191266552252 no 2146 0.361584906900147 3066 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_155 k072-0202 43.6 µM -0.354509127537266 0.37180217429857 no 2147 0.36147868242567 3103 5857737 SGTC_2626 ethyl orsellinate 100 µM -0.355080013476039 0.371579724755227 no 2148 0.361264824628695 3003 75653 A natural product. SGTC_3338 9144300 39.5675 µM -0.355768966618666 0.371311326633851 no 2149 0.361006795771991 3088 4901274 SGTC_1337 1486-1011 40.3 µM -0.355881605168818 0.371267451548918 no 2150 0.360964616046369 3077 X1337 SGTC_1792 st045773 43.6 µM -0.35674393052147 0.37093161314971 no 2151 0.360641757372845 3009 2919270 SGTC_3253 9135987 49.47 µM -0.359270526476107 0.369948180130864 no 2152 0.359696360462409 3137 4182430 SGTC_1056 3448-1962 115 µM -0.359381201658429 0.369905121145586 no 2153 0.359654967803088 3108 715507 SGTC_1613 st002381 52.1 µM -0.360992519492921 0.369278411185912 no 2154 0.359052519571325 3105 551167 SGTC_609 0986-0026 86.3 µM -0.362785717207396 0.368581368711608 no 2155 0.358382481039378 3053 2848610 SGTC_2016 5121758 140 µM -0.363102969513099 0.368458092979146 no 2156 0.358263983222277 3021 2795203 SGTC_2864 9034755 47.6 µM -0.363909015032747 0.368144946242409 no 2157 0.357962976271431 3109 4930451 SGTC_575 k072-0246 11.9 µM -0.36417243714547 0.368042626367569 no 2158 0.357864623927602 3074 6796779 SGTC_580 1123-0028 41 µM -0.365662250952806 0.367464121019941 no 2159 0.357308558767258 3048 1677248 YPR107C YTH1 SGTC_33 0986-0033 35.816 µM -0.366387948450739 0.367182436305149 no 2160 0.357037805617447 3097 2848082 SGTC_3208 9114115 49.47 µM -0.368394089246568 0.366404110598495 no 2161 0.356289702074508 3116 650895 SGTC_2080 5212524 12.4 µM -0.36884717190884 0.366228403289898 no 2162 0.356120820882636 3165 260183 SGTC_919 tnp00227 403.569 nM -0.369018861942057 0.366161828518014 no 2163 0.356056832829333 3055 1269246 A methoxyflavone. YNL221C POP1 SGTC_3157 9099274 49.47 µM -0.369256721829257 0.366069602286488 no 2164 0.355968190287267 3203 17217662 SGTC_2799 7812892 81.82 µM -0.370310936162445 0.365660941345982 no 2165 0.355575413119735 3210 20205235 SGTC_771 0250-0039 27.3 µM -0.371032206838082 0.365381432141622 no 2166 0.355306771768039 3068 3005115 SGTC_2231 micatex 6.853 µM -0.371253896282757 0.365295536667779 no 2167 0.355224216714425 3113 20737 An antifungal of unknown mechanism. SGTC_721 1187-1332 279 µM -0.371711331599657 0.365118320795784 no 2168 0.355053893603782 2991 25730 SGTC_1006 4099-6547 255 µM -0.372205522101595 0.364926897896214 no 2169 0.354869917478243 3155 3146833 SGTC_842 0271-0008 11.1 µM -0.372254639102997 0.36490787444202 no 2170 0.35485163415976 3190 1221709 SGTC_3006 9075424 71.4286 µM -0.373222504720888 0.364533079320839 no 2171 0.354491423990415 3086 7465181 SGTC_2732 terfenadine 20 µM -0.374114211862066 0.364187890284853 no 2172 0.3541596728274 3064 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_687 k029-0044 34.9 µM -0.375166926780413 0.363780515262146 no 2173 0.353768162696719 3189 5829338 SGTC_2393 9031399 185.94 µM -0.375192197504611 0.363770737997816 no 2174 0.353758766282089 3199 1526623 YDL150W RPC53 SGTC_1540 guanosine 70.6 µM -0.375917708843406 0.363490074907771 no 2175 0.353489037380156 3101 6802 Guanosine is a purine nucleoside SGTC_2401 5128683 200 µM -0.376086419232794 0.363424820012141 no 2176 0.353426325164084 3060 708373 SGTC_849 0386-0493 241 µM -0.3762428628341 0.363364313285245 no 2177 0.353368176255063 3046 726119 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.37803439120875 0.362671658286976 no 2178 0.352702522961207 3221 16725076 SGTC_762 1165-0429 115 µM -0.378171910551167 0.362618507995285 no 2179 0.352651445412072 3186 5967793 SGTC_3139 9095020 49.47 µM -0.378220796195143 0.362599614663695 no 2180 0.352633288905232 2970 25236292 SGTC_758 0868-0029 16 µM -0.378637632008939 0.362438529483957 no 2181 0.352478486493932 3174 762687 SGTC_3005 9076496 71.4286 µM -0.378896635004926 0.362338450674505 no 2182 0.352382311554118 3176 21368410 SGTC_1332 1480-0653 17.5 µM -0.37964885462075 0.362047846224338 no 2183 0.352103045238512 3213 5749438 SGTC_128 0906-2981 13.371 µM -0.380129541982304 0.361862184256365 no 2184 0.351924628750072 3238 6740226 SGTC_1832 st054113 55 µM -0.38092353431409 0.36155558175167 no 2185 0.351629994421078 3206 1251267 SGTC_2482 5981709 142.65 µM -0.381755778993103 0.361234303386499 no 2186 0.351321261071436 3097 877755 SGTC_1924 st058459 75.1 µM -0.381810330738439 0.361213247735275 no 2187 0.351301027725685 3144 688683 SGTC_1648 st011736 69.8 µM -0.382140958809181 0.361085642313751 no 2188 0.351178406166657 3216 2855514 SGTC_371 0195-0006 7.36 µM -0.382234779284249 0.361049435253195 no 2189 0.351143613355157 3015 3928593 SGTC_600 1495-0418 41.6 µM -0.38270070276121 0.360869645195221 no 2190 0.350970846663578 3075 5377768 SGTC_2192 5915882 198.485 µM -0.382724931071697 0.36086029684092 no 2191 0.350961863530461 3110 2876149 SGTC_2776 terbinafine 19.92 µM -0.382819376769798 0.360823856304982 no 2192 0.350926846684753 3137 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_349 k015-0014 24 µM -0.38528507585362 0.359872949175334 no 2193 0.350013108715324 3016 2196908 SGTC_2673 kobusone 100 µM -0.385561881232411 0.359766252027182 no 2194 0.349910584348978 3100 6710676 An epoxy ketone and protein crosslinker. SGTC_1942 st076330 65.2 µM -0.38556728435319 0.359764169453902 no 2195 0.349908583226721 3209 24208414 SGTC_1022 4477-0945 21.3 µM -0.385679749223506 0.359720822056114 no 2196 0.34986693121671 3072 4648966 SGTC_864 0469-0573 172 µM -0.386097069453718 0.359559989861851 no 2197 0.3497123900683 3098 689425 SGTC_1738 st035555 74 µM -0.386112538586948 0.359554028647849 no 2198 0.349706662049906 3183 5331140 SGTC_2876 9059903 25.97 µM -0.387787702451162 0.358908686900768 no 2199 0.349086573408178 3179 6916095 SGTC_304 1310-0298 97 µM -0.388347224958193 0.358693225488142 no 2200 0.348879546861159 3142 1550234 SGTC_917 harmaline 728.087 nM -0.389067686210705 0.358415855872668 no 2201 0.348613038307118 3172 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_389 tpck 16.7 µM -0.389439845501945 0.358272607903821 no 2202 0.348475400702208 3161 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_724 3910-0327 137 µM -0.392385891165146 0.357139349742295 no 2203 0.347386554567965 3176 2885483 SGTC_1915 st067105 30.6 µM -0.392552554489259 0.357075276742955 no 2204 0.347324994022193 3141 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.392712063326348 0.357013958030177 no 2205 0.347266079905948 3081 5355888 SGTC_948 3448-0295 75.3 µM -0.394434817900417 0.356351928857546 no 2206 0.346630021036526 3108 678569 SGTC_3141 9094609 49.47 µM -0.394444233017579 0.356348311953913 no 2207 0.346626546063199 3036 25236309 YDL196W YDL196W SGTC_3221 9128209 49.47 µM -0.394517365856629 0.356320217742899 no 2208 0.346599554309075 3119 16460723 SGTC_132 0417-1715 25.805 µM -0.39647517954901 0.355568407739472 no 2209 0.345877257355216 3267 6769098 SGTC_341 1486-1430 230 µM -0.397708721964939 0.355095009612126 no 2210 0.345422453732783 3044 2054753 YPL210C SRP72 SGTC_3159 9100096 49.47 µM -0.397906557759298 0.355019106705631 no 2211 0.345349532972832 3030 25236875 SGTC_2103 5378138 10 µM -0.39835511621267 0.354847031304771 no 2212 0.345184219024716 3169 244142 SGTC_988 1497-1057 103 µM -0.398690913319352 0.354718232639498 no 2213 0.345060482031004 3220 3533044 SGTC_54 0159-0055 9 µM -0.399698843239487 0.354331729839803 no 2214 0.344689172110796 3330 3319099 SGTC_827 3253-0474 693 µM -0.401747199110566 0.353546725710716 no 2215 0.34393504224692 3230 5402065 SGTC_1986 st071812 45 µM -0.403035985704271 0.353053134829347 no 2216 0.343460875834266 3191 11838594 SGTC_3260 9137109 49.47 µM -0.403134175887111 0.353015539207325 no 2217 0.343424760089457 3158 17478346 SGTC_2009 4012297 12.05 µM -0.405992973643942 0.351921576662717 no 2218 0.342373881558276 3203 45595307 SGTC_2707 st078556 66.6 µM -0.407658393073055 0.351284842423469 no 2219 0.341762243877634 3170 17250899 SGTC_2733 amorolfine 100 µM -0.408772445362409 0.35085914328774 no 2220 0.341353331512372 3184 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.410132030135126 0.350339875431591 no 2221 0.340854548850699 3148 4620898 SGTC_617 3770-0098 35 µM -0.412878443386777 0.34929178821235 no 2222 0.339847837717254 3157 5962639 SGTC_299 1273-0059 1.44 µM -0.413906954881856 0.348899582360574 no 2223 0.339471125120466 3226 2848077 SGTC_1401 3807-4679 7.6 µM -0.414039330785692 0.348849114712313 no 2224 0.339422651477005 3186 3291456 SGTC_1188 1403-0014 4.57 µM -0.415027009653282 0.348472651566819 no 2225 0.339061065383107 3150 9614867 SGTC_860 0443-0016 25.1 µM -0.415098005782323 0.348445596464086 no 2226 0.339035079631337 3179 5337942 SGTC_1431 4049-0260 9.09 µM -0.415221827358651 0.348398412560884 no 2227 0.33898976072894 3143 3854841 SGTC_2336 9001819 198.65 µM -0.41528282641874 0.348375168898159 no 2228 0.338967435828328 3346 2989602 SGTC_2903 5923464 63.88 µM -0.417303368612249 0.347605564531574 no 2229 0.338228262438068 3227 2876576 SGTC_2133 5320837 200 µM -0.41748078445278 0.347538018537976 no 2230 0.338163388254835 3269 2841355 SGTC_306 1672-3436 11.6 µM -0.418181446349119 0.347271308936965 no 2231 0.337907229987843 3228 6797378 SGTC_2819 7996655 46.38 µM -0.418931683561298 0.346985812133428 no 2232 0.337633030448302 3146 6456960 SGTC_1393 3470-5649 58.2 µM -0.419433404547592 0.346794934646559 no 2233 0.337449707633059 3185 4108395 SGTC_1202 1988-0068 29.6 µM -0.420391328450482 0.346430604828813 no 2234 0.337099800922029 3135 2850480 SGTC_3268 9137683 49.47 µM -0.421325099504303 0.346075597823692 no 2235 0.336758852264146 3126 1953228 SGTC_1308 1187-1617 41.4 µM -0.42216740421939 0.34575548107147 no 2236 0.336451415833832 3118 2882570 SGTC_3108 9121785 49.47 µM -0.423152387329147 0.345381279433092 no 2237 0.336092041257225 3211 17140271 SGTC_2134 5324836 1.464 µM -0.423604350104841 0.345209626310444 no 2238 0.335927191143391 3122 699272 SGTC_809 3998-0021 90 µM -0.424021548844012 0.345051204647581 no 2239 0.335775048967134 3278 715485 SGTC_2272 7805186 180 µM -0.424090193312791 0.345025141084049 no 2240 0.335750018585975 3276 2956062 YPR165W RHO1 SGTC_104 0074-0074 590.992 µM -0.424470995856559 0.344880567825639 no 2241 0.335611176747397 3166 3943124 SGTC_2914 7968218 45.32 µM -0.424607373109654 0.344828797144378 no 2242 0.335561458616572 3211 2977111 SGTC_1454 4239-0054 42.6 µM -0.426271538026442 0.344197291535027 no 2243 0.334954997428999 3326 1340767 SGTC_1313 1220-0047 237 µM -0.429052276607775 0.343143046011594 no 2244 0.333942590676759 3216 3528706 SGTC_199 4063-0024 41.6 µM -0.431066604300221 0.342380126682426 no 2245 0.333209971127207 3268 306215 SGTC_2390 9097792 176.6 µM -0.431100513240128 0.342367289286522 no 2246 0.333197643736872 3190 4497149 SGTC_2825 7998094 58.44 µM -0.431291218162932 0.34229509476923 no 2247 0.333128317470749 3183 2987815 SGTC_1747 st037496 66.6 µM -0.432626013298312 0.341789947351862 no 2248 0.332643243990091 3149 723305 SGTC_257 daunorubicin 18.5 µM -0.43451687463019 0.341074843896719 no 2249 0.331956571823482 3278 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1525 8-methoxypsoralen 92.5 µM -0.43616655048977 0.340451420033678 no 2250 0.331357947474941 3374 4114 Related to psoralen; DNA damaging agent. SGTC_550 4123-0385 25.7 µM -0.436242868813987 0.34042258934603 no 2251 0.33133026395573 3165 5731123 SGTC_908 3448-7491 47.7 µM -0.436478923428689 0.34033342116316 no 2252 0.331244643926204 3154 1203031 SGTC_1149 3909-7961 23.3 µM -0.436952494370065 0.340154559566408 no 2253 0.331072900289814 3201 735261 SGTC_297 0986-0032 24 µM -0.43716247762423 0.340075263123229 no 2254 0.330996759842354 3171 2847425 SGTC_1778 st046819 58.9 µM -0.437792632371861 0.339837338862073 no 2255 0.330768306141382 3175 671715 SGTC_119 0121-0043 24.815 µM -0.438164134373631 0.339697102658808 no 2256 0.330633652860834 3267 1092378 SGTC_928 2764-0428 58.7 µM -0.438714899292698 0.33948923833712 no 2257 0.330434064923953 3259 662578 SGTC_165 k038-0023 64.381 µM -0.439459249610411 0.339208390487195 no 2258 0.330164401527933 3172 46368543 SGTC_2027 5150920 200 µM -0.439885528982946 0.339047592925271 no 2259 0.330010008652782 3212 786715 SGTC_441 propafenone 146 µM -0.440831220014005 0.338690971909109 no 2260 0.329667594972412 3147 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1512 0259-0544 12.2 µM -0.441083202247645 0.338595973540711 no 2261 0.329576381882434 3185 18476 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.441542646069967 0.338422787709648 no 2262 0.329410097480469 3237 1241132 A phosphatase inhibitor. SGTC_190 3970-0790 3.722 µM -0.44327696323681 0.337769350791474 no 2263 0.328782708206565 3257 2832352 SGTC_1258 0671-0043 57.1 µM -0.444665348799411 0.337246602237909 no 2264 0.328280807103735 3231 4298767 SGTC_1201 1889-3372 45.9 µM -0.445389557726284 0.336974050983576 no 2265 0.328019128602439 3161 5392199 SGTC_651 3253-0966 34.4 µM -0.446552387900061 0.336536606561621 no 2266 0.327599139617351 3198 781462 SGTC_2835 9006588 71.43 µM -0.446663026666928 0.336494996938695 no 2267 0.327559190651486 3350 2345538 SGTC_2021 4019055 173 µM -0.447151836737697 0.336311186585686 no 2268 0.327382716865633 3340 44827708 YER133W GLC7 SGTC_3258 9138477 49.47 µM -0.447962904753923 0.336006281856403 no 2269 0.327089984266161 3225 4970355 SGTC_832 4083-0019 164 µM -0.448207697995901 0.335914277938958 no 2270 0.327001653790119 3301 1990758 SGTC_806 3966-4455 5.86 µM -0.449270919896628 0.335514787182951 no 2271 0.32661811642361 3187 714982 SGTC_361 000s-0510 1.45 µM -0.451307710199514 0.334750011122595 no 2272 0.325883894330363 3247 660 SGTC_3303 9125618 40.5795 µM -0.452685145834154 0.334233198222661 no 2273 0.325387738608837 3246 22695467 SGTC_1439 4092-1168 46 µM -0.452791165412567 0.334193432756013 no 2274 0.325349562903524 3264 2886240 SGTC_220 paclitaxel 373.376 µM -0.453053188264249 0.334095162090638 no 2275 0.325255221143345 3268 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_484 loperamide 105 µM -0.453086397251131 0.334082707999423 no 2276 0.325243264992312 3206 3955 An opioid-receptor agonist. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.453806672170165 0.333812634237426 no 2277 0.324983990441804 3205 4174840 SGTC_2400 5203494 178.7 µM -0.454564649046835 0.333528516719706 no 2278 0.324711235969923 3275 6777674 SGTC_3114 9122766 49.47 µM -0.458612886968442 0.332012708481412 no 2279 0.323256090346954 3256 17176985 SGTC_1141 3253-0389 52.6 µM -0.459063337538619 0.331844212594657 no 2280 0.323094341694488 3278 5402031 SGTC_2424 5537928 59.2 µM -0.459956394763359 0.331510255493078 no 2281 0.322773759903365 3204 5382802 SGTC_445 e6 berbamine 66 µM -0.46077194771747 0.331205397933177 no 2282 0.322481114919746 3290 6610268 A calcium/calmodulin antagonist. SGTC_2888 9058547 12.99 µM -0.460953360504582 0.331137600172786 no 2283 0.322416033486875 3189 16476514 SGTC_1581 himbacine 57.9 µM -0.46105245927402 0.331100567223595 no 2284 0.322380484322551 3202 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2423 st077119 87.2 µM -0.461458581757681 0.330948817583503 no 2285 0.322234815175837 3264 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1375 2910-0797 186 µM -0.464214406178217 0.329919825031552 no 2286 0.321247070410106 3226 742508 SGTC_742 0kpi-0133 140 µM -0.464362444249179 0.329864585668573 no 2287 0.321194046175164 3342 2728852 SGTC_19 0279-0214 38.434 µM -0.465776009648986 0.329337310701768 no 2288 0.320687919414695 3265 3566274 YBR002C RER2 SGTC_2521 angolensin 13.4 µM -0.4658932648635 0.329293588478453 no 2289 0.320645951164213 3337 821428 A flavenoid. SGTC_818 4072-2707 53.5 µM -0.466719292147788 0.328985644902413 no 2290 0.320350362607381 3166 882871 SGTC_664 1222-0054 14.9 µM -0.467054539718373 0.328860697453239 no 2291 0.320230428913082 3250 6813991 SGTC_2922 7999257 32.47 µM -0.467358304337781 0.328747500277528 no 2292 0.320121774354041 3306 2988377 SGTC_1482 3346-2049 8.48 µM -0.467447454475795 0.328714281668259 no 2293 0.320089888877249 3311 3826804 SGTC_363 0455-0021 3.06 µM -0.46779476382846 0.328584882172137 no 2294 0.319965682737701 3229 4597466 SGTC_3034 9090421 49.47 µM -0.46914878260469 0.328080602220374 no 2295 0.31948164599107 3279 17173761 SGTC_1279 0874-0590 65.2 µM -0.469301965983715 0.328023571528997 no 2296 0.319426905099025 3274 3523074 SGTC_109 0132-0036 33.701 µM -0.470919018158623 0.327421782299846 no 2297 0.318849283159912 3252 67274 A color developer. SGTC_1220 1838-0075 193 µM -0.470980279679344 0.327398992503068 no 2298 0.318827408768604 3245 5529645 SGTC_427 1354-0053 47.3 µM -0.471808950715207 0.327090783193693 no 2299 0.318531580752475 3397 6813657 SGTC_1728 st035614 33.7865 µM -0.471859751463915 0.327071892600399 no 2300 0.318513449107876 3273 15945546 SGTC_3000 9075062 71.4286 µM -0.472237736444357 0.326931350308522 no 2301 0.31837855353911 3224 17057871 SGTC_143 4032-1194 15.74 µM -0.47250361861308 0.326832504763251 no 2302 0.318283679731093 3221 1806963 SGTC_923 1900-2434 73.3 µM -0.472847843082678 0.32670455238271 no 2303 0.318160869016761 3257 5910570 SGTC_1363 1636-0063 10.4 µM -0.474746257925001 0.325999255184459 no 2304 0.317483921293821 3261 6072185 SGTC_2699 st077704 54.6 µM -0.478410319955365 0.324639747110278 no 2305 0.316179094929103 3306 645852 SGTC_2095 5432005 200 µM -0.479576346035853 0.324207595038416 no 2306 0.315764334592703 3224 783734 SGTC_2142 5622915 118.518 µM -0.480153951207095 0.323993610901852 no 2307 0.315558963876816 3271 5322196 SGTC_2780 5215298 71.43 µM -0.480719952231707 0.323783982130468 no 2308 0.315357774323959 3371 2834131 SGTC_726 3448-4391 34.2 µM -0.480787226382725 0.323759069640325 no 2309 0.315333864831913 3440 1356692 SGTC_249 wiskostatin 11.211 µM -0.481369937577161 0.323543317182868 no 2310 0.315126799399862 3351 2775510 A n-wasp and actin depolymerizer. SGTC_2730 imipramine 71.33 µM -0.481584443576524 0.32346390992776 no 2311 0.315050589678625 3351 3696 A tricyclic antidepressant. SGTC_1616 st002734 56.1 µM -0.482664669574074 0.32306414694 no 2312 0.314666926533767 3218 4026101 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.483940334470719 0.322592320278849 no 2313 0.314214107043505 3284 16623 A steroid. SGTC_156 3474-0145 5.642 µM -0.484319988983823 0.322451953611647 no 2314 0.314079395992916 3354 2265471 SGTC_392 N-ethylmaleimide 8.33 µM -0.484495047923452 0.322387238974763 no 2315 0.314017288983292 3232 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_39 0986-0283 58.349 µM -0.485592668407101 0.321981600587841 no 2316 0.31362799781227 3424 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_596 1155-0152 116 µM -0.48711316547896 0.321420033572409 no 2317 0.313089068511619 3299 280313 SGTC_2584 androsterone 48.74 µM -0.492546258555123 0.319416763025124 no 2318 0.311166614391089 3362 2754130 A steroid. SGTC_1158 4092-0494 91.8 µM -0.492636845104098 0.319383406698672 no 2319 0.31113460453097 3392 1148199 SGTC_691 1548-0686 185 µM -0.49321345810159 0.319171117048926 no 2320 0.310930884800225 3281 46495133 SGTC_974 1326-0144 138 µM -0.493814925384761 0.318949740050542 no 2321 0.310718445676967 3285 5411856 SGTC_1969 st069479 40.1 µM -0.494446075135074 0.318717507503177 no 2322 0.310495590498807 3377 3895485 SGTC_3178 9107506 49.47 µM -0.496419907242944 0.317991692558082 no 2323 0.309799091340634 3388 8897194 SGTC_3293 9120939 62.045 µM -0.49687863457105 0.317823109885603 no 2324 0.309637319461692 3376 934087 SGTC_821 1114-0266 29.2 µM -0.496951408473011 0.317796368885416 no 2325 0.309611658865359 3340 3123235 SGTC_713 1488-1073 324 µM -0.497436967366276 0.317617973063961 no 2326 0.309440471097133 3350 3312542 SGTC_2481 5478948 45.16 µM -0.498549237629586 0.31720948120061 no 2327 0.3090484869685 3380 77792 SGTC_97 0535-0701 19.132 µM -0.500303861078677 0.316565531678015 no 2328 0.308430567903951 3338 2832013 YGL099W LSG1 SGTC_2188 6126565 140.678 µM -0.50300057325223 0.315576917715539 no 2329 0.307481934560473 3370 874518 SGTC_1059 3448-6867 171 µM -0.503803737633465 0.31528273234961 no 2330 0.30719965046811 3367 3934407 SGTC_2223 6903751 107.57 µM -0.504223802498718 0.315128916398076 no 2331 0.307052057884917 3346 5598863 SGTC_678 1218-2179 85.9 µM -0.505858319340995 0.314530707415569 no 2332 0.306478057149455 3332 6820081 YOR116C RPO31 SGTC_2710 st078562 53.7235 µM -0.506206408903629 0.31440337457904 no 2333 0.306355878184364 3300 17250908 SGTC_224 benfluorex 43.875 µM -0.507260544997892 0.314017901241415 no 2334 0.305986009192642 3390 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1736 st036774 51 µM -0.507836233342455 0.313807470853033 no 2335 0.305784098553575 3465 1272247 SGTC_1686 st019653 115.5 µM -0.508156021643824 0.313690605329976 no 2336 0.305671964994845 3386 97252 SGTC_230 MPP+ 141.667 µM -0.508404722248555 0.313599731479666 no 2337 0.305584770885172 3349 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1235 benzylparaben 21.5 µM -0.508605320301427 0.31352644228089 no 2338 0.305514449499658 3360 7180 SGTC_3241 9133421 49.47 µM -0.509025861082243 0.31337282013247 no 2339 0.305367048573194 3353 17018221 SGTC_2591 skatole 100 µM -0.510055918136945 0.312996680515142 no 2340 0.305006143507592 3386 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_547 1120-0019 610 nM -0.511370905298356 0.312516777461257 no 2341 0.304545681891077 3336 3676939 SGTC_292 k038-0015 474 µM -0.512837966587537 0.311981750119159 no 2342 0.304032334660035 3388 46368540 SGTC_374 0880-0231 82.3 µM -0.516985204906225 0.310471427476526 no 2343 0.302583243437407 3351 6833587 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.517347398350387 0.310339676586236 no 2344 0.302456836114268 3380 688662 SGTC_1290 0986-0249 10.2 µM -0.517590814106154 0.310251145743381 no 2345 0.302371896104704 3340 53329 SGTC_530 4358-1714 28 µM -0.518164205446633 0.310042645520215 no 2346 0.302171853303338 3377 1564641 SGTC_2305 7443522 69.23 µM -0.518981335717429 0.309745620919753 no 2347 0.301886878399527 3363 5415886 SGTC_2244 6635614 200 µM -0.520461310007913 0.309207970567749 no 2348 0.301371043749328 3154 836499 SGTC_830 4076-0286 57.8 µM -0.520850219662564 0.309066753778796 no 2349 0.301235557884555 3402 6866659 SGTC_2947 9072639 7.68 µM -0.521846461311739 0.308705137702309 no 2350 0.300888618792115 3404 16488146 SGTC_936 3005-4620 401 µM -0.522466111182596 0.308480310517611 no 2351 0.300672917950403 3460 777207 SGTC_226 1,3-diallylurea 8.28947 mM -0.523327899837203 0.308167747636463 no 2352 0.300373044406503 3355 74537 YKL182W FAS1 SGTC_171 k064-0041 9.68 µM -0.52342002772614 0.308134341915506 no 2353 0.300340994988555 3307 53325 SGTC_1797 st048695 56.8 µM -0.523802256802172 0.307995762014944 no 2354 0.300208041779784 3391 592262 YIL048W NEO1 SGTC_1815 st051655 58.2 µM -0.524115425919088 0.307882240700228 no 2355 0.300099129979347 3379 5984156 SGTC_1515 3460-0031 42.1 µM -0.524255839963116 0.30783134769464 no 2356 0.300050303552863 3365 2876596 SGTC_935 2996-0153 430 µM -0.524858230109012 0.307613053621377 no 2357 0.299840874143882 3432 23738523 SGTC_578 3460-0051 92 µM -0.526304019031051 0.307089406777137 no 2358 0.299338495521692 3460 2876744 SGTC_1219 1469-0211 33.1 µM -0.527508152601985 0.306653584543627 no 2359 0.298920378240348 3380 6822282 SGTC_31 0508-1974 57.237 µM -0.52755844677685 0.306635387088627 no 2360 0.298902920117411 3401 6810525 SGTC_1671 st016596 74.5 µM -0.528694680274045 0.306224401804082 no 2361 0.298508634045798 3431 2829167 SGTC_382 3229-0966 23.2 µM -0.529576884710902 0.305905469027344 no 2362 0.298202662251485 3456 5722370 SGTC_2848 9016370 25.97 µM -0.529918233822776 0.305782104643515 no 2363 0.29808431170339 3464 7894410 SGTC_3242 9133940 49.47 µM -0.531456441961425 0.305226466094555 no 2364 0.297551258977414 3455 17248444 SGTC_95 0471-0001 561.058 µM -0.531573369123555 0.305184247461592 no 2365 0.297510756683433 3363 4015405 SGTC_2224 6650123 117.647 µM -0.533138670971518 0.304619317158368 no 2366 0.296968795768554 3375 2908370 SGTC_1449 4112-4002 201 µM -0.533345920428556 0.304544554006846 no 2367 0.296897072805166 3372 2059539 SGTC_1398 3558-0053 112 µM -0.534095724540983 0.304274137957176 no 2368 0.296637653814065 3291 4532369 SGTC_2075 5212009 200 µM -0.53545925858769 0.303782655132342 no 2369 0.296166161358606 3410 780898 SGTC_401 neomycin 50 µM -0.536188794990626 0.303519840892272 no 2370 0.295914038368337 3378 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_411 enrofloxacin 100 µM -0.536226821744132 0.303506144604323 no 2371 0.295900899274985 3488 71188 A bacterial gyrase inhibitor. SGTC_56 0957-0365 83.25 µM -0.536654483432468 0.303352130546416 no 2372 0.295753151054859 3433 6752360 SGTC_615 k087-0205 167 µM -0.537746425573651 0.302959047308211 no 2373 0.295376061600817 3347 9642773 SGTC_1732 st034308 51.822 µM -0.538404045319389 0.302722423837252 no 2374 0.295149067087959 3337 830119 SGTC_1253 0550-0034 176 µM -0.539154681657066 0.302452432542177 no 2375 0.294890063699126 3413 5969915 SGTC_1910 st062352 60.4 µM -0.539363907102592 0.302377196906629 no 2376 0.294817890156759 3338 2245730 SGTC_2011 4012611 177 µM -0.539567036473462 0.302304161397936 no 2377 0.294747827282757 3338 2049887 SGTC_2470 5664817 21.68 µM -0.540383219891031 0.302010781093145 no 2378 0.29446638877361 3434 2859561 SGTC_2779 methotrexate 400 µM -0.541689003166868 0.301541678366972 no 2379 0.294016383307038 3471 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_997 3996-0078 137 µM -0.541975341359075 0.301438855194061 no 2380 0.293917746546663 3364 735687 SGTC_2268 7933382 153.85 µM -0.542516163046875 0.30124469083699 no 2381 0.293731487978939 3439 935025 YOR257W CDC31 SGTC_1813 st051246 8.6015 µM -0.542564354079223 0.301227392155015 no 2382 0.293714893675776 3393 5291959 SGTC_3288 9119690 36.221 µM -0.544312941320899 0.300600021144275 no 2383 0.293113071480182 3366 17595618 YKL019W RAM2 SGTC_2154 5570129 200 µM -0.545743772305598 0.300087096352728 no 2384 0.292621039303249 3448 673366 SGTC_1100 amiodarone 5.07 µM -0.545943246921847 0.300015620076193 no 2385 0.292552474736025 3450 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_536 3852-0578 10.6 µM -0.546592039361512 0.299783196325958 no 2386 0.292329519696321 3471 2869208 SGTC_650 1328-0195 38 µM -0.546848493471909 0.29969134655839 no 2387 0.292241412018173 3426 2780821 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.547396159626681 0.299495241062694 no 2388 0.292053296556411 3374 689007 SGTC_1902 st060212 70.5 µM -0.547897890948142 0.299315634750088 no 2389 0.291881008540499 3477 688944 SGTC_2768 sulfasalazine 50.2 µM -0.548103798203188 0.299241939635588 no 2390 0.29181031636804 3498 5384001 An antioxidant and salicylic acid derivative. SGTC_1171 0368-0077 21.4 µM -0.549540772014077 0.298727869739449 no 2391 0.291317196089285 3366 3239779 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.549963666243485 0.298576658022798 no 2392 0.291172147351373 3460 688798 SGTC_2076 5212012 200 µM -0.550025248858578 0.298554641205957 no 2393 0.291151027907574 3374 604802 SGTC_3100 9120536 49.47 µM -0.55063256468364 0.298337555184359 no 2394 0.290942790364123 3368 16421196 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.551164219876695 0.298147573183975 no 2395 0.290760552626538 3445 229346 A bile salt which induces apoptosis. SGTC_2112 5488546 200 µM -0.551877957644387 0.297892612373443 no 2396 0.290515985621871 3353 600757 SGTC_748 act1.228 77.9 µM -0.552017343329547 0.297842832740048 no 2397 0.290468235426145 3413 4421505 YNR035C ARC35 SGTC_1905 st060207 84.5 µM -0.553735093460671 0.297229674182983 no 2398 0.289880077216785 3379 1948547 SGTC_2747 doxorubicin 7.63 µM -0.556490124734751 0.296247460097945 no 2399 0.288937921734107 3371 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1442 4112-3290 3 µM -0.55728851370613 0.295963099728675 no 2400 0.288665161129837 3427 704353 SGTC_3101 9120531 49.47 µM -0.557877168146657 0.295753520320801 no 2401 0.288464131669196 3531 24824904 SGTC_2079 5212404 121 µM -0.557995300419976 0.295711469750092 no 2402 0.288423796652084 3476 758462 SGTC_81 0411-0046 9.971 µM -0.558101025870774 0.295673837863582 no 2403 0.288387700067988 3399 12925265 SGTC_1945 st075991 56.6 µM -0.55863716787087 0.295483037524326 no 2404 0.288204684268353 3379 1084980 SGTC_2316 5844804 197.44 µM -0.559170573381884 0.29529326724991 no 2405 0.288022656975985 3434 776813 SGTC_2649 anisomycin 9.56 µM -0.559863025535411 0.295046996479344 no 2406 0.287786435204861 3441 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2053 5265679 138 µM -0.560749609761364 0.294731820773895 no 2407 0.287484121272054 3400 764595 SGTC_866 0495-0101 262 µM -0.561364033884123 0.294513487575947 no 2408 0.28727469860908 3344 635694 SGTC_2361 9034121 116 µM -0.561480408242681 0.294472142813823 no 2409 0.287235041261774 3377 6496917 SGTC_1338 1486-1223 76 µM -0.561708039888873 0.294391278996797 no 2410 0.287157477823129 3433 3444526 SGTC_1982 st072467 71.9 µM -0.56210856272564 0.294249022245513 no 2411 0.287021027341316 3325 3163533 SGTC_3254 9136651 49.47 µM -0.562770036473898 0.29401415111998 no 2412 0.286795743129422 3412 16454030 SGTC_793 0488-0545 106 µM -0.562838888741903 0.293989708555411 no 2413 0.286772298294745 3342 292548 SGTC_526 4469-0568 170 µM -0.56292494514445 0.293959159841745 no 2414 0.286742996570413 3459 2901964 SGTC_2528 xanthyletin 44.79 µM -0.565892248251709 0.292906711458836 no 2415 0.285733515728917 3411 65188 An natural product with antifungal activity of unknown mechanism. SGTC_44 0929-0055 61.211 µM -0.565926889058812 0.292894435328741 no 2416 0.285721740865624 3360 1379590 SGTC_1603 st002045 67.8 µM -0.566350488872956 0.292744337866602 no 2417 0.285577772422711 3486 5887985 SGTC_907 3448-6986 75.5 µM -0.568424481430927 0.292009959825717 no 2418 0.284873385461017 3532 590582 SGTC_2788 5282734 71.43 µM -0.568743413846543 0.291897105483915 no 2419 0.284765140498708 3510 743706 SGTC_1102 cgs 12066b 26.1 µM -0.570149718127871 0.291399726678001 no 2420 0.284288078155633 3431 6438352 A 5-HT1B full agonist. SGTC_2284 7945075 39.21 µM -0.570562339344062 0.291253866719977 no 2421 0.284148176672599 3476 1245402 SGTC_1037 k284-1091 78.7 µM -0.571827888313557 0.290806712896887 no 2422 0.283719290836236 3482 3334711 SGTC_3207 9114163 49.47 µM -0.572026388711255 0.290736606287436 no 2423 0.283652048554414 3572 849233 SGTC_2978 9011784 42.97 µM -0.572600022801087 0.29053405394371 no 2424 0.283457772137634 3436 2994934 SGTC_1645 Cervolide 78 µM -0.57282678460531 0.290454001718267 no 2425 0.283380990824658 3438 23173 A fragrance. SGTC_1045 1348-1485 165 µM -0.572963600314632 0.290405707564488 no 2426 0.283334669990193 3469 6810614 SGTC_872 0588-0139 234 µM -0.574386898250543 0.289903525155434 no 2427 0.282853008429007 3479 2047100 SGTC_298 1391-0729 10 µM -0.575604428031198 0.289474267423275 no 2428 0.282441293687613 3439 3237558 SGTC_868 0527-0199 213 µM -0.576064479581247 0.289312147342898 no 2429 0.282285799655789 3373 2849450 SGTC_1154 4088-0362 150 µM -0.576817064123897 0.28904703199252 no 2430 0.282031520472893 3482 6618304 SGTC_1955 wogonin 32.4 µM -0.577307393624412 0.288874363562004 no 2431 0.281865909969329 3565 5281703 A flavanone. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.578342053479563 0.288510169806379 no 2432 0.281516603825432 3359 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3195 9113082 49.47 µM -0.579566883660859 0.288079317175687 no 2433 0.28110336538137 3481 17018038 SGTC_811 0416-0114 265 µM -0.580353151617189 0.287802895595626 no 2434 0.280838245452771 3495 6612453 SGTC_982 1491-0518 27.5 µM -0.580450701140234 0.287768609672517 no 2435 0.280805361379476 3399 3091256 SGTC_878 0828-0289 13.7 µM -0.580713931262891 0.287676101292496 no 2436 0.280716635448383 3498 745350 YLR208W SEC13 SGTC_2217 6934799 96.0675 µM -0.580950163298154 0.287593092963083 no 2437 0.280637021201805 3469 675606 SGTC_572 0960-0087 17.7 µM -0.582168824607232 0.28716505395368 no 2438 0.280226485067154 3435 6796365 SGTC_1668 st014914 51.6 µM -0.582254320141889 0.287135036078462 no 2439 0.280197694711514 3503 2839556 SGTC_1019 4262-0212 3.4 µM -0.582302376472839 0.287118163931987 no 2440 0.280181512520562 3518 4677213 SGTC_2446 5162541 200 µM -0.584274844209559 0.286426053583372 no 2441 0.27951770697441 3436 1549321 SGTC_1203 3992-3522 103 µM -0.584759923845193 0.286255967547613 no 2442 0.279354577493176 3665 5322312 SGTC_1262 0737-0114 49.6 µM -0.58493623424077 0.286194158788191 no 2443 0.279295296787733 3542 765919 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.585265315059764 0.286078810586794 no 2444 0.279184666558002 3554 94937 An inhibitor of serotonin biosynthesis. SGTC_698 k064-0052 127 µM -0.585515017685865 0.285991300480497 no 2445 0.2791007358666 3545 5088751 SGTC_69 0096-0274 206.684 µM -0.586400980990423 0.285680910874787 no 2446 0.278803042617891 3641 6741392 SGTC_433 pimozide 108 µM -0.586585032143525 0.285616450251761 no 2447 0.27874121883249 3362 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2473 5854593 8.94 µM -0.586886756764667 0.285510791578771 no 2448 0.278639882327626 3450 2872951 SGTC_3125 9127534 49.47 µM -0.587617394459946 0.285255012177611 no 2449 0.278394566454045 3428 1639235 SGTC_2354 9060492 162 µM -0.589275374206631 0.284674997030816 no 2450 0.277838280794534 3514 6471895 SGTC_3172 9105863 49.47 µM -0.590197316622309 0.284352715400571 no 2451 0.277529185467555 3473 2348785 SGTC_146 3448-8650 53.125 µM -0.591343590005402 0.283952258157753 no 2452 0.277145114253021 3489 2891488 YIL048W NEO1 SGTC_2174 5790901 200 µM -0.591579886665847 0.283869740114619 no 2453 0.277065972861192 3492 786020 SGTC_1465 k213-0056 144 µM -0.59179202230133 0.283795669213001 no 2454 0.276994932996691 3418 24048857 YMR208W ERG12 SGTC_3152 9099253 49.47 µM -0.591940259970492 0.283743914907294 no 2455 0.276945296540871 3512 25236131 SGTC_3131 9127911 49.47 µM -0.592092729658692 0.283690687789704 no 2456 0.276894247563551 3575 45595681 SGTC_1328 1441-0025 69.2 µM -0.593406068069136 0.283232399907762 no 2457 0.276454714442655 3472 4562601 SGTC_1687 st020778 55.3625 µM -0.59377734113792 0.283102909026275 no 2458 0.276330523066305 3509 4259299 SGTC_1830 st055982 50.3 µM -0.594529080623668 0.28284080788206 no 2459 0.276079148966258 3495 455313 An antimicrobial agent. SGTC_188 3229-0966 278.469 µM -0.594607788083666 0.28281337251676 no 2460 0.276052836479812 3550 5722370 SGTC_414 piperonyl butoxide 100 µM -0.594882646873919 0.282717573947596 no 2461 0.275960958811157 3417 5794 A potent inhibitor of cytochrome P450. SGTC_2171 5739187 198.077 µM -0.595466268631962 0.282514211654474 no 2462 0.275765920064728 3421 2262761 SGTC_3301 9125354 19.7965 µM -0.597619982291098 0.281764362040183 no 2463 0.275046763989763 3504 41905162 SGTC_992 3909-8734 162 µM -0.597648477409085 0.281754447445959 no 2464 0.275037255254245 3474 4288319 SGTC_78 0336-0123 156.75 µM -0.602093685416494 0.280209844270501 no 2465 0.273555888793247 3374 6765896 SGTC_892 0929-0076 29 µM -0.602227800821418 0.280163306209371 no 2466 0.273511256246253 3492 5751038 SGTC_219 mitoxanthrone 164.414 µM -0.602732586297868 0.279988179173231 no 2467 0.273343299949342 3478 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1958 st076513 41.9 µM -0.60520506518136 0.279131160662022 no 2468 0.272521375354833 3448 732122 YGL099W LSG1 SGTC_3168 9103419 49.47 µM -0.605260349943529 0.279112012268229 no 2469 0.272503011111559 3487 16649256 SGTC_3306 9127676 59.7925 µM -0.606474507377101 0.27869163861236 no 2470 0.272099852765811 3487 41905287 SGTC_746 1095-0025 46.6 µM -0.609012167045954 0.277814029887564 no 2471 0.27125818710272 3559 6749286 SGTC_1126 isoteolin 1.0172 µM -0.609277268704549 0.277722426649581 no 2472 0.271170335751891 3521 133323 SGTC_729 4092-0585 94.1 µM -0.609462326946937 0.277658490360983 no 2473 0.271109018190177 3472 2169061 SGTC_126 0417-1624 672.48 µM -0.609475283095229 0.277654014374485 no 2474 0.27110472553355 3622 41912 YDL195W SEC31 SGTC_1850 st056238 17 µM -0.609519773654847 0.277638644400093 no 2475 0.271089985091569 3535 5393177 SGTC_3032 9089427 49.47 µM -0.61035610716434 0.277349797001555 no 2476 0.27081296867466 3514 17173707 SGTC_1336 1486-0901 104 µM -0.610862686172218 0.277174909543144 no 2477 0.270645244662821 3492 5006114 SGTC_3130 9127414 49.47 µM -0.612966755411068 0.276449094756161 no 2478 0.269949160887343 3549 1494646 SGTC_2405 ticlatone 3.52 µM -0.613457719453008 0.276279867165726 no 2479 0.269786865552961 3406 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1479 0549-0158 134 µM -0.613849584729637 0.276144833846558 no 2480 0.269657363833454 3551 5440202 SGTC_3179 9107801 49.47 µM -0.61605670337654 0.27538488586941 no 2481 0.268928548182953 3526 4818259 SGTC_222 nsc-310342 10.666 µM -0.618155598619149 0.274663156933104 no 2482 0.268236387753873 3517 432556 SGTC_1312 1218-2183 165 µM -0.61922577853608 0.274295522849885 no 2483 0.267883815910223 3569 6744073 SGTC_843 0310-0051 143 µM -0.619398613302486 0.274236172497365 no 2484 0.267826897223613 3524 2065037 SGTC_2924 9010168 62.78 µM -0.620078682412733 0.274002702707234 no 2485 0.267602993112498 3550 2993929 SGTC_1162 k048-0130 20.1 µM -0.622212066645482 0.273270943445197 no 2486 0.266901216314661 3538 6797406 SGTC_8 0354-0001 70 µM -0.622503158918951 0.273171172744217 no 2487 0.26680553363719 3581 4993152 SGTC_2658 polymyxin b sulfate 77.05 µM -0.623483359539238 0.2728353457152 no 2488 0.266483467020889 3527 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3305 9127027 53.8275 µM -0.626553817159516 0.271784701961695 no 2489 0.265475874621679 3497 41905295 SGTC_620 0109-0052 432 µM -0.627168543207916 0.27157459825046 no 2490 0.265274380399599 3578 493037 SGTC_545 4218-0007 221 µM -0.627902725276707 0.271323772378139 no 2491 0.265033832793807 3540 2840508 SGTC_2962 9082311 13.18 µM -0.628148038171868 0.271239989451022 no 2492 0.264953483119074 3519 16459453 SGTC_3343 9148379 18.9835 µM -0.628794923764973 0.271019117276289 no 2493 0.264741661879972 3603 1955036 SGTC_471 1-acyl-paf 4 µM -0.630645482600654 0.270387759598126 no 2494 0.264136176414011 3520 16759367 SGTC_1236 0330-0013 258 µM -0.634234971152417 0.26916522847237 no 2495 0.262963744029302 3522 4617066 SGTC_252 miconazole 1.30953 nM -0.634496392198467 0.269076300467942 no 2496 0.262878460284882 3521 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1281 0884-0031 11.8 µM -0.634816991018807 0.268967262000036 no 2497 0.262773890205079 3580 1548255 SGTC_2138 5575593 77.673 µM -0.634843528832855 0.268958237251093 no 2498 0.262765235289813 3562 762213 SGTC_1023 4482-3888 16 µM -0.635068237318148 0.268881826438003 no 2499 0.262691955788138 3593 3303168 SGTC_1904 st060225 78 µM -0.635362928341655 0.268781634994091 no 2500 0.262595870186699 3565 66595 SGTC_2147 5545932 89.7195 µM -0.636909120186071 0.268256255655565 no 2501 0.262092020894931 3570 797404 SGTC_1164 k060-0068 93.7 µM -0.638576802826183 0.267690174784227 no 2502 0.26154913798746 3612 5963676 SGTC_2809 7964133 12.99 µM -0.639066226081011 0.267524158507541 no 2503 0.261389925029532 3557 1253665 SGTC_3058 9093861 49.47 µM -0.639402640393641 0.267410074200418 no 2504 0.26128051587047 3618 17217477 SGTC_1128 3448-9350 235 µM -0.639743568575499 0.267294484197712 no 2505 0.261169662711799 3528 619386 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.639897742564333 0.267242220553918 no 2506 0.261119540814078 3571 4330530 SGTC_914 3820-6779 408 µM -0.641104147046593 0.266833438050164 no 2507 0.260727510011961 3548 2893481 SGTC_2449 5812982 45.77 µM -0.641789247836421 0.266601436733688 no 2508 0.260505015933337 3563 776185 SGTC_315 k915-0449 187 µM -0.642966518511341 0.266203006246505 no 2509 0.260122912701886 3594 20970215 YNL149C PGA2 SGTC_3018 9082602 49.47 µM -0.643393231003397 0.266058665951402 no 2510 0.25998448727419 3582 17332089 SGTC_500 h-89 112 µM -0.644209220077528 0.265782758896601 no 2511 0.259719886439324 3625 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3028 9087778 49.47 µM -0.644892187564908 0.265551941435076 no 2512 0.259498527419763 3531 17217395 SGTC_1378 2093-0007 380 nM -0.645030686509659 0.26550514637634 no 2513 0.259453649920229 3579 3618014 SGTC_1590 st077108 57.8 µM -0.645715265600071 0.26527390702127 no 2514 0.25923188619837 3573 5489485 SGTC_1628 st004252 77.7 µM -0.646614810255821 0.26497021141699 no 2515 0.258940635175674 3578 692968 SGTC_1247 0448-0043 5.84 µM -0.646856096583246 0.264888780710763 no 2516 0.258862541240367 3601 3089013 YGL099W LSG1 SGTC_301 4119-0100 24.5 µM -0.648066420082101 0.264480505742465 no 2517 0.258470995889247 3591 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1546 5-methoxyflavanone 78.7 µM -0.648211226111311 0.26443168019539 no 2518 0.25842417101248 3626 147795 SGTC_2165 5727197 32.143 µM -0.648260022702745 0.264415228044675 no 2519 0.258408393002185 3733 1361712 SGTC_2973 9094665 17.96 µM -0.649015647977473 0.264160529616885 no 2520 0.258164130978361 3612 25237061 YIL048W NEO1 SGTC_1425 4048-4433 7.33 µM -0.650222910402382 0.263753857456482 no 2521 0.257774122123218 3645 23734946 SGTC_2023 5144124 124 µM -0.65269338588531 0.262922662258053 no 2522 0.256976983675051 3577 2830192 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.653498351020069 0.262652120083939 no 2523 0.256717526071906 3572 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2685 mycophenolic acid 18.85 µM -0.653856448165205 0.262531812366453 no 2524 0.256602147494734 3562 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_768 0384-0033 77.3 µM -0.654602837773413 0.262281143091471 no 2525 0.256361748272457 3579 3965305 YMR134W ERG29 SGTC_1223 0764-0573 147 µM -0.655637994697506 0.261933696543319 no 2526 0.256028536456036 3628 1609797 SGTC_1122 capsaicin 818.572 nM -0.658154337486405 0.261090080749142 no 2527 0.255219481470176 3626 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1013 4112-3890 241 µM -0.658445259930772 0.260992637774828 no 2528 0.255126030317383 3560 705171 SGTC_3052 9092717 49.47 µM -0.658806114332837 0.260871797438875 no 2529 0.255010140241 3603 25237534 SGTC_3150 9097574 49.47 µM -0.660656586272548 0.26025257714945 no 2530 0.254416285558595 3588 17217476 SGTC_1116 jasmonic acid  1.58368 µM -0.663586434777492 0.259273718149126 no 2531 0.253477520903297 3658 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1649 st011737 51.3 µM -0.664830842526223 0.258858539373569 no 2532 0.253079346597055 3592 1761035 SGTC_3313 9133968 57.047 µM -0.664894111075871 0.258837439923433 no 2533 0.253059111293699 3601 1494643 SGTC_2098 5376439 882.5 nM -0.666428914032756 0.258325870732396 no 2534 0.252568493170309 3665 2844116 SGTC_3126 9127922 49.47 µM -0.66733280198759 0.258024838802733 no 2535 0.252279789206206 3652 45595682 SGTC_2594 a-mangostin 100 µM -0.66743961203721 0.257989278679684 no 2536 0.252245685321066 3632 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1804 st050076 49.1 µM -0.667611430883419 0.257932080601569 no 2537 0.252190829571356 3637 3895976 SGTC_166 k072-0058 166.424 µM -0.667880868906427 0.257842398585233 no 2538 0.252104820102052 3643 5846229 SGTC_1720 st037298 9.481 µM -0.667974157215084 0.257811351492054 no 2539 0.252075044400519 3614 597396 SGTC_2398 5228213 48.84 µM -0.668013980752366 0.25779809849214 no 2540 0.252062334114923 3649 80771 YMR134W ERG29 SGTC_167 3672-0051 66.205 µM -0.668515155294508 0.257631341274162 no 2541 0.251902405569802 3598 3237971 SGTC_2601 securinine 100 µM -0.669133825301149 0.257425566732106 no 2542 0.251705057231523 3595 442872 A GABA receptor antagonist. SGTC_3354 9151612 71.43 µM -0.669380607815269 0.257343508745568 no 2543 0.251626359345524 3619 27261949 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.669438985389802 0.257324099527866 no 2544 0.251607744888332 3679 65057 A dermal irritant. YDR527W RBA50 SGTC_1471 k673-0312 37 µM -0.670623693801253 0.256930375332819 no 2545 0.251230142260498 3630 24099884 SGTC_2663 amphotericin b 100 µM -0.671925653898122 0.256498045682692 no 2546 0.250815513835026 3613 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_854 0422-0053 192 µM -0.673097063518285 0.256109390832472 no 2547 0.250442770982739 3638 3596728 SGTC_1027 k015-0025 8.67 µM -0.67397387283581 0.255818680731841 no 2548 0.250163962256207 3614 3598955 SGTC_312 4092-0653 6.84 µM -0.674490759476595 0.255647385358477 no 2549 0.249999679274407 3634 1148278 SGTC_1125 tnp00248 1.32998 µM -0.674839330155055 0.255531903441334 no 2550 0.249888924776643 3722 24207736 SGTC_1271 0832-2808 169 µM -0.675286152566633 0.255383910463743 no 2551 0.249746989971138 3652 3663794 SGTC_195 4234-0266 16.654 µM -0.675383643594673 0.255351626212237 no 2552 0.24971602727257 3631 2303354 SGTC_57 miconazole 162.5 nM -0.676003940582917 0.255146264218024 no 2553 0.249519071581622 3583 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_40 0327-0103 19.753 µM -0.677921656318066 0.254511911955958 no 2554 0.248910684027155 3574 409036 SGTC_1277 0873-0036 22 µM -0.678783770571829 0.254227006662125 no 2555 0.248637439238543 3668 5965735 SGTC_2647 atorvastatin 60.16 µM -0.678954361803948 0.254170650729333 no 2556 0.24858338974894 3621 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2958 9077254 16.72 µM -0.679751278541992 0.253907470872104 no 2557 0.248330980561698 3662 16457351 SGTC_1957 st077035 62.4 µM -0.680285817584829 0.253731020797563 no 2558 0.2481617514274 3707 705593 SGTC_3036 9090181 49.47 µM -0.682134571261037 0.253121248376442 no 2559 0.247576931064282 3658 25236586 SGTC_3049 9092223 49.47 µM -0.682579583321847 0.252974585716711 no 2560 0.24743626942899 3612 8623917 SGTC_1307 1187-1599 12.2 µM -0.682963446264243 0.25284811190856 no 2561 0.24731497043033 3649 1538471 SGTC_1724 st037281 8.293 µM -0.683451170322409 0.252687466330946 no 2562 0.247160897642376 3663 574124 YDL195W SEC31 SGTC_1963 st076565 50.3 µM -0.684378993461068 0.252382010250111 no 2563 0.246867938644755 3668 4914280 SGTC_380 3970-0968 6 µM -0.684437588084191 0.252362726381196 no 2564 0.246849443707194 3618 2891601 SGTC_2409 alverine citrate 63.97 µM -0.685843836280815 0.251900154113951 no 2565 0.246405794973546 3739 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1456 k015-0012 13 µM -0.688416370976922 0.251055102308535 no 2566 0.245595308715184 3716 2989616 SGTC_1455 4262-0120 131 µM -0.689623171694411 0.250659197847173 no 2567 0.245215595825342 3721 1529587 SGTC_2172 5754775 163.918 µM -0.689660815807226 0.250646853595853 no 2568 0.245203756401066 3596 2263357 SGTC_3021 9087658 49.47 µM -0.689763730161607 0.250613107581137 no 2569 0.245171390446405 3630 25237042 SGTC_1224 0823-0416 294 µM -0.689874586969033 0.250576759898076 no 2570 0.245136529207598 3695 3598164 SGTC_331 k048-0133 24.5 µM -0.691814052764963 0.249941300785016 no 2571 0.24452705520221 3633 6813582 SGTC_201 4262-0159 12.803 µM -0.691984031466332 0.249885648655965 no 2572 0.244473678601175 3640 1341029 SGTC_1335 1486-0900 202 µM -0.692812736540033 0.249614419471519 no 2573 0.244213539102335 3686 X1335 SGTC_2789 5281112 71.43 µM -0.692993999076122 0.249555114403499 no 2574 0.244156658727039 3678 765948 SGTC_87 0100-0052 35.5 µM -0.694023171752273 0.249218533971217 no 2575 0.243833838725765 3733 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2468 5987765 72.9 µM -0.69464911640682 0.249013943275655 no 2576 0.243637611741182 3690 26772094 SGTC_1575 cyproterone acetate 48 µM -0.695680228472635 0.248677118122335 no 2577 0.243314555103296 3635 9880 An androgen receptor antagonist and liver toxin. SGTC_496 calpeptin 138 µM -0.69665969791733 0.248357387513546 no 2578 0.243007893098513 3629 73364 A calpain inhibitor. SGTC_1655 st012546 55.1 µM -0.697458817838772 0.248096691254856 no 2579 0.242757851656409 3635 720985 YLR208W SEC13 SGTC_2237 6667747 47.222 µM -0.697893288892543 0.247955015388607 no 2580 0.242621965853584 3619 729940 YDL015C TSC13 SGTC_642 0335-0876 158 µM -0.698272529843287 0.247831384704757 no 2581 0.242503387571999 3688 6812350 SGTC_3316 9136639 10.545 µM -0.698945244035932 0.247612164170033 no 2582 0.242293125475406 3687 4903665 SGTC_2883 9059145 45.46 µM -0.699095592381093 0.247563183613903 no 2583 0.242246146432974 3669 16476510 SGTC_2322 7413319 38.22 µM -0.701238201364384 0.246865726271637 no 2584 0.24157718658251 3722 1840400 SGTC_2897 9048598 12.99 µM -0.701501934759726 0.246779949115285 no 2585 0.241494913811222 3674 6467404 SGTC_1131 3454-3128 32.3 µM -0.703330548847383 0.246185646283537 no 2586 0.240924888515899 3742 710982 SGTC_1039 k821-0043 94 µM -0.704451282607579 0.245821785512102 no 2587 0.240575889492966 3645 15992768 SGTC_470 aa-861 153 µM -0.706352586630308 0.245205163332483 no 2588 0.239984449219318 3673 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1423 4048-0112 5.59 µM -0.706860161249207 0.245040689825434 no 2589 0.239826691740438 3687 X1423 SGTC_3353 9151644 39.2805 µM -0.707537663712791 0.244821245731504 no 2590 0.239616207771036 3709 4909158 SGTC_1907 st060210 83.7 µM -0.708650207573249 0.244461120648554 no 2591 0.239270785594638 3704 688793 SGTC_967 1306-0166 352 µM -0.709340426479715 0.24423784365853 no 2592 0.239056623521355 3667 4437607 SGTC_659 k018-0002 107 µM -0.709670986479322 0.244130950672741 no 2593 0.238954094030227 3667 6797879 YHR007C ERG11 SGTC_2033 5192550 145 µM -0.709824662903029 0.244081265013071 no 2594 0.238906436544013 3685 182073 SGTC_2028 5153890 36.43 µM -0.710810124949514 0.243762781506863 no 2595 0.238600952771134 3665 2830968 YPR165W RHO1 SGTC_781 4335-2806 94.4 µM -0.711947511209353 0.243395477884682 no 2596 0.23824863987746 3800 845254 SGTC_274 sirtinol 40.1 µM -0.712448112355499 0.243233910293344 no 2597 0.238093665736787 3706 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1350 1495-0454 146 µM -0.712972041068958 0.243064875907355 no 2598 0.237931529124353 3704 1069057 SGTC_2301 7769476 200 µM -0.713055696442133 0.243037892174589 no 2599 0.237905646477525 3716 977820 SGTC_3246 9135460 32.98 µM -0.713841284153463 0.242784573423545 no 2600 0.237662664033351 3624 41446951 SGTC_2614 arthonioic acid 13.39 µM -0.714799424456249 0.242475807306982 no 2601 0.237366495433911 3657 6710684 SGTC_481 bay k-8644 50 µM -0.715813760675452 0.242149163663409 no 2602 0.237053177201347 3677 2303 A calcium channel antagonist. SGTC_2980 9014342 25.29 µM -0.71811822489816 0.24140795147916 no 2603 0.236342196896395 3705 2996599 SGTC_3161 9100388 49.47 µM -0.718167935509415 0.241391976056782 no 2604 0.236326872974324 3722 25236368 SGTC_568 1193-0097 7.48 µM -0.71824792745879 0.241366270373239 no 2605 0.236302215596793 3601 3646150 SGTC_172 1112-0046 2.638 µM -0.718708376593678 0.241218332408874 no 2606 0.236160310510408 3662 2802135 YIL048W NEO1 SGTC_448 monastrol 171 µM -0.719378370926429 0.24100315760514 no 2607 0.235953909893014 3633 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1485 3909-9022 254 µM -0.719771034370013 0.240877098682197 no 2608 0.235832990946856 3730 714516 SGTC_681 1642-0006 26.6 µM -0.722648043721609 0.239954571559544 no 2609 0.234948071769594 3721 4446530 SGTC_1523 st012844 44.7 µM -0.723616383973383 0.239644502471784 no 2610 0.234650639993663 3800 4274103 SGTC_867 0518-0118 155 µM -0.724946534415422 0.239218936070771 no 2611 0.234242415625666 3737 6848158 SGTC_1708 st033234 31.827 µM -0.726489686254884 0.238725740177809 no 2612 0.233769313968755 3804 674664 SGTC_17 0960-0276 49.807 µM -0.726496619866594 0.23872352543115 no 2613 0.233767189448183 3708 6821114 SGTC_906 1165-0455 526 µM -0.728262050180551 0.238159974517667 no 2614 0.233226594223346 3698 3252859 SGTC_2643 anethole 100 µM -0.728331885709116 0.238137697004181 no 2615 0.2332052240514 3721 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1548 st061468 90.8 µM -0.728937541930825 0.237944540746966 no 2616 0.233019934504354 3720 390799 SGTC_2381 9035592 200 µM -0.729228559795798 0.237851759710454 no 2617 0.232930931949587 3719 4749657 SGTC_901 1112-0062 60.1 µM -0.729473818349483 0.237773582864419 no 2618 0.232855938718119 3721 1908457 SGTC_2556 citropten 84.59 µM -0.730005864053934 0.237604040276473 no 2619 0.232693300089117 3761 2775 A potential DNA crosslinker. SGTC_775 4577-0580 57.3 µM -0.730404596167222 0.237477023124079 no 2620 0.23257145488495 3778 2006902 SGTC_1789 tunicamycin 25 nM -0.730620463509954 0.23740827357489 no 2621 0.232505504596511 3700 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3267 9137951 49.47 µM -0.73078246557886 0.237356686245836 no 2622 0.232456017683188 3717 16643986 SGTC_3025 9087895 49.47 µM -0.731237639327861 0.237211775378625 no 2623 0.232317006716594 3743 17173641 SGTC_2998 9066762 71.4286 µM -0.731539778715195 0.237115611962418 no 2624 0.232224758292338 3749 4945196 SGTC_643 k048-0106 28.4 µM -0.731573817706412 0.237104779544843 no 2625 0.232214366872393 3747 6763920 SGTC_2618 avocadyne 43.43 µM -0.733233429031476 0.236576962151592 no 2626 0.231708034866507 3664 3015189 SGTC_2906 7926292 26.41 µM -0.736343726865519 0.235589516624258 no 2627 0.230760770779407 3698 2966319 SGTC_632 0781-2353 4.65 µM -0.737883565701285 0.235101497162125 no 2628 0.230292603252313 3791 6811515 YHR007C ERG11 SGTC_991 3996-0057 64.7 µM -0.739337616944607 0.234641179321855 no 2629 0.229851006330491 3753 715343 SGTC_466 geldanamycin 89.2 µM -0.739495091955793 0.234591356430358 no 2630 0.2298032094689 3628 5288382 HSP90 inhibitor. SGTC_2859 9028643 45.46 µM -0.741195246843293 0.23405382395857 no 2631 0.229287532487906 3696 17151580 SGTC_3310 9130229 44.1445 µM -0.743112900409939 0.233448345165714 no 2632 0.22870666498521 3803 7761258 SGTC_1817 st052116 64.4 µM -0.744332344883371 0.233063770882126 no 2633 0.228337718925478 3738 4361398 SGTC_2587 piperic acid 92.2 µM -0.745212726000907 0.232786345282051 no 2634 0.228071565404331 3760 5370536 SGTC_457 grayanotoxin iii 135 µM -0.745686952185686 0.232636983256181 no 2635 0.227928271453261 3687 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_439 amiodarone 34.4 µM -0.745819690653326 0.232595185563871 no 2636 0.227888171777768 3667 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2934 9036370 36.88 µM -0.748505128964464 0.23175047165049 no 2637 0.227077766278538 3763 6462800 SGTC_2321 7390090 138.78 µM -0.751061121888245 0.230948065337814 no 2638 0.226307936035429 3758 649046 SGTC_1007 4101-0031 70 µM -0.751307948396214 0.230870660967435 no 2639 0.226233673391209 3702 1146276 SGTC_973 1325-0077 65.9 µM -0.751673692981479 0.230755990733236 no 2640 0.226123657208237 3791 2835149 SGTC_421 streptovitacin 30 mM -0.753087261900387 0.230313100123034 no 2641 0.225698739223664 3851 91467 include heat shock SGTC_353 1988-1175 58.3 µM -0.753299739003858 0.230246569239356 no 2642 0.225634907808133 3628 2788357 SGTC_531 3788-1495 174 µM -0.75397907113075 0.230033928732407 no 2643 0.225430894458466 3729 2896655 SGTC_1390 3413-2614 145 µM -0.754640893276773 0.229826874819731 no 2644 0.225232240076142 3809 3421432 SGTC_682 0kpi-0099 17 µM -0.754927394463126 0.229737274061181 no 2645 0.225146273842215 3781 1714895 YML126C ERG13 SGTC_1606 st000094 49.2 µM -0.7574494659573 0.228949362720988 no 2646 0.224390315141011 3774 1242210 SGTC_1066 ketoconazole 628 nM -0.758944484359829 0.228483026115862 no 2647 0.223942883443071 3814 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1678 st019265 80.2 µM -0.759086246943812 0.228438834254732 no 2648 0.223900482821647 3756 5367020 SGTC_1684 st024538 14.6195 µM -0.759115725974165 0.228429645315954 no 2649 0.223891666334676 3751 6732859 SGTC_777 1315-0167 517 µM -0.759502195472314 0.228309197722905 no 2650 0.223776100615881 3815 4221767 SGTC_3002 9075603 71.4286 µM -0.759677601995087 0.228254542074278 no 2651 0.223723660108917 3744 20105405 SGTC_2769 toremifene 3.73 µM -0.759754327258717 0.228230637242369 no 2652 0.223700724095128 3779 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2724 maprotiline 69.64 µM -0.761139060799285 0.227799446075014 no 2653 0.22328700598169 3722 4011 A tricyclic antidepressant. SGTC_565 1418-0001 44.5 µM -0.76202828924752 0.227522791782157 no 2654 0.223021560154121 3800 2862145 SGTC_1487 3970-0795 2.82 µM -0.763392905910633 0.227098604242168 no 2655 0.222614554718046 3838 3765103 SGTC_2127 5253358 187.912 µM -0.763780488736884 0.226978206477599 no 2656 0.222499032980844 3724 20612 SGTC_3050 9093513 49.47 µM -0.764306408284848 0.226814893712765 no 2657 0.222342333706765 3782 25236664 SGTC_2824 7998404 51.95 µM -0.76510999215926 0.226565486467328 no 2658 0.222103025160966 3769 837851 SGTC_816 0325-0417 81.3 µM -0.766440716834778 0.226152811907578 no 2659 0.221707056752631 3807 68101 SGTC_269 exalamide 29 µM -0.768119172151411 0.225632907954524 no 2660 0.221208193828456 3743 3316 A derivative of salicylamide. SGTC_2177 5811945 192 µM -0.768541646354102 0.225502152577172 no 2661 0.221082729179022 3812 5343475 SGTC_2722 naftopidil 47.16 µM -0.76948475719191 0.225210415433045 no 2662 0.22080279496866 3723 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3204 9114183 49.47 µM -0.769911919723114 0.225078349508527 no 2663 0.220676071376672 3803 17027248 SGTC_3250 9135583 49.47 µM -0.770971880695587 0.224750830776725 no 2664 0.220361799501752 3818 7699353 SGTC_1435 4092-0789 56.7 µM -0.772096849885643 0.224403520891377 no 2665 0.220028533913409 3789 2248285 SGTC_1625 st003711 30.1 µM -0.774914021727342 0.223535117946246 no 2666 0.219195233037904 3818 24207034 YER133W GLC7 SGTC_1685 st024049 53.0905 µM -0.775199226826622 0.223447309168063 no 2667 0.219110972499353 3804 1941139 SGTC_848 0368-0089 85.6 µM -0.775706246436142 0.223291256730411 no 2668 0.21896122542955 3790 762535 SGTC_3291 9121177 71.43 µM -0.775970092160072 0.223210073826433 no 2669 0.21888332249784 3798 17015612 SGTC_2453 5731132 22.18 µM -0.776172206981009 0.223147896320668 no 2670 0.218823656983281 3816 1362040 SGTC_972 1319-0219 195 µM -0.77728588514104 0.222805467336532 no 2671 0.218495060364847 3772 23903702 SGTC_1173 0443-0020 122 µM -0.777594001532798 0.222710781935945 no 2672 0.218404199203734 3799 5331295 SGTC_296 1222-0039 74.9 µM -0.778592754448655 0.222404018870534 no 2673 0.218109824277395 3781 5984176 SGTC_3121 9125696 49.47 µM -0.779367182038654 0.222166322434269 no 2674 0.217881725054045 3857 1235365 SGTC_733 4069-0007 56.1 µM -0.779845610025689 0.222019550162618 no 2675 0.217740878067553 3811 5717425 YNL287W SEC21 SGTC_2704 st078022 71.1 µM -0.78035522587075 0.2218632709779 no 2676 0.217590907309552 3816 54697681 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.780375970047244 0.221856910883925 no 2677 0.217584803935205 3857 6708561 SGTC_1395 3486-0190 4.35 µM -0.781783552607831 0.221425594181137 no 2678 0.217170894309858 3793 6748079 SGTC_2099 5377090 177.372 µM -0.781879565864952 0.221396190917513 no 2679 0.217142677512543 3821 2243829 SGTC_533 1222-0222 6.71 µM -0.782988349852334 0.221056796816885 no 2680 0.216816976707288 3890 3982874 SGTC_2680 butyl paraben 22.24 µM -0.784644400174963 0.220550441661401 no 2681 0.216331045001768 3847 7184 An antifungal and steroid mimetic. SGTC_834 0312-0008 75.7 µM -0.7853585595182 0.220332285036827 no 2682 0.216121685285246 3793 6385573 YIL048W NEO1 SGTC_2306 7482397 179.52 µM -0.786292692845238 0.2200471190481 no 2683 0.215848016196291 3789 891448 SGTC_431 k089-0097 107 µM -0.787364151706005 0.219720292097072 no 2684 0.215534362849282 3743 5499420 SGTC_191 3914-0123 66.505 µM -0.787592076262432 0.219650804266539 no 2685 0.21546767550078 3763 3144412 SGTC_2714 st079313 56.9 µM -0.788219819464649 0.219459488152239 no 2686 0.21528406902689 3793 2939799 SGTC_1712 st032288 53.4 µM -0.788696311629522 0.219314332466227 no 2687 0.215144762089334 3776 2883011 SGTC_2426 5582046 32.21 µM -0.792482141432014 0.218163002668455 no 2688 0.214039800385005 3807 2251934 SGTC_1387 3342-1166 1.8 µM -0.795073525130518 0.217376934756016 no 2689 0.213285366989823 3826 3418228 SGTC_3199 9111318 49.47 µM -0.795631220153049 0.217207978168249 no 2690 0.213123207391993 3790 8548020 SGTC_1478 0453-0656 35.7 µM -0.795813346669149 0.217152818435017 no 2691 0.213070266498235 3838 5258496 SGTC_3281 9140613 49.47 µM -0.79702718558053 0.216785395966197 no 2692 0.212717621424397 3826 16013766 SGTC_1416 3966-0321 25.3 µM -0.799162655488104 0.216139874032626 no 2693 0.212098051451438 3848 582530 YLR208W SEC13 SGTC_2206 7254556 146.969 µM -0.800409129445902 0.215763597909325 no 2694 0.211736896636351 3836 4398905 SGTC_1565 sinapyl alcohol 95.1 µM -0.802195201344951 0.215225094424996 no 2695 0.21122002587938 3860 5280507 A phenol propionate derived from cinnamic acid. SGTC_2433 5607874 27.82 µM -0.803897187116306 0.214712669617263 no 2696 0.210728177361773 3839 2252428 SGTC_2476 5806916 10.51 µM -0.806470377392429 0.213939294918159 no 2697 0.209985840843671 3751 2870194 SGTC_3200 9114385 49.47 µM -0.806612534715283 0.213896616728126 no 2698 0.209944874892679 3872 17018030 YLR208W SEC13 SGTC_1343 1487-0095 224 µM -0.806658771049709 0.213882736815727 no 2699 0.209931551825904 3807 4560101 YGL055W OLE1 SGTC_147 4466-0538 29.23 µM -0.806856429045559 0.213823406804012 no 2700 0.209874601990647 3872 6742687 YHR072W ERG7 SGTC_2706 st078239 82.5 µM -0.808449954835388 0.213345436353693 no 2701 0.209415802209199 3819 15434492 SGTC_3088 9117578 49.47 µM -0.810046933397588 0.212867055760007 no 2702 0.208956600929271 3893 678341 SGTC_1432 4049-0298 68.4 µM -0.810837861695203 0.212630362387409 no 2703 0.208729394193368 3850 741646 SGTC_899 1083-0020 478 µM -0.81275330325516 0.212057784158261 no 2704 0.208179756767332 3923 767123 SGTC_2155 5570423 76 µM -0.815920928142074 0.211112874887707 no 2705 0.207272680806655 3800 797402 SGTC_2386 9075165 157.42 µM -0.815973991776009 0.211097066936077 no 2706 0.207257505520835 3816 16452277 SGTC_3182 9108849 49.47 µM -0.815999157126554 0.211089570280737 no 2707 0.20725030889349 3883 17133045 SGTC_2362 9071156 126 µM -0.816713586088733 0.21087680990779 no 2708 0.20704606268586 3877 653133 SGTC_3031 9088762 49.47 µM -0.817872751673596 0.210531872499402 no 2709 0.206714925387472 3828 205253 SGTC_752 1896-0090 130 µM -0.818555728910128 0.210328791428467 no 2710 0.206519967081685 3831 772567 SGTC_1739 st037196 92.5 µM -0.820201697646806 0.209839840826469 no 2711 0.206050567177471 3906 612214 SGTC_2105 5350118 200 µM -0.824447286410667 0.208581737042512 no 2712 0.204842728017997 3865 2133313 SGTC_3160 9100216 49.47 µM -0.825510354130104 0.208267413619285 no 2713 0.204540953379978 3770 17191039 SGTC_706 4262-0057 46.9 µM -0.826600895371657 0.207945257505079 no 2714 0.204231654856066 3855 883298 SGTC_3163 9099914 49.47 µM -0.827422796921049 0.207702654624958 no 2715 0.20399873189042 3878 16268368 SGTC_1444 4112-3581 28 µM -0.828700828447907 0.207325746964489 no 2716 0.203636858440038 3900 2877249 SGTC_2588 indole-3-carbinol 100 µM -0.829542955229023 0.207077614305302 no 2717 0.203398620368067 3920 3712 Induces cell cycle arrest. SGTC_3279 9140807 49.47 µM -0.832059397208016 0.206337192329561 no 2718 0.202687709288859 3918 45595718 SGTC_217 ketoconazole 989 nM -0.834424633148822 0.205642692676856 no 2719 0.202020870495817 3774 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3255 9139072 49.47 µM -0.834768354849185 0.2055418819359 no 2720 0.201924073289764 3882 17646060 SGTC_2282 7944268 200 µM -0.83593877441828 0.205198827652875 no 2721 0.201594673812718 3879 2970414 SGTC_1596 piperlongumine 63 µM -0.836097371140894 0.20515236855698 no 2722 0.201550063591771 3921 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2990 9074105 71.4286 µM -0.836697636488778 0.204976584297675 no 2723 0.201381274007785 3823 6502001 SGTC_1988 st071872 53.4 µM -0.838204065604337 0.204535829694391 no 2724 0.20095805204351 3910 16414116 SGTC_1323 1348-1351 11.2 µM -0.838338727302664 0.204496457535208 no 2725 0.200920245670199 3835 6989654 SGTC_1466 k213-0079 57.5 µM -0.839067126989154 0.204283567465352 no 2726 0.200715820891462 3835 3657981 SGTC_754 3474-0146 171 µM -0.839512508320352 0.204153460477877 no 2727 0.200590886515818 3866 24762078 SGTC_1186 1319-0216 26 µM -0.839675098603218 0.204105976103836 no 2728 0.200545289784905 3954 4565136 SGTC_2081 5214970 32.255 µM -0.840837559923189 0.203766671826599 no 2729 0.200219471126324 3801 2063512 SGTC_861 0443-0273 110 µM -0.842275491900157 0.203347427517311 no 2730 0.199816883015513 3920 6149169 SGTC_2240 6690706 185.951 µM -0.846812667431952 0.202027944324008 no 2731 0.198549773216157 3773 805876 SGTC_122 0236-0016 402.397 µM -0.847194616039879 0.201917101891033 no 2732 0.198443326989262 3921 6808838 SGTC_463 ikarugamyin 104 µM -0.849923923501443 0.201126110178887 no 2733 0.197683691923247 3944 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2488 5268135 45.7 µM -0.850738653021055 0.200890350737253 no 2734 0.197457273212033 3972 1270356 YLR208W SEC13 SGTC_825 1988-2224 89.6 µM -0.851082296751081 0.200790959803759 no 2735 0.197361819389251 3895 1180859 SGTC_707 0865-0008 204 µM -0.853845195036546 0.199992928959328 no 2736 0.196595384559147 3909 723043 SGTC_2048 5246248 200 µM -0.858321125210254 0.198704163221471 no 2737 0.195357583772967 3902 677046 SGTC_1960 st011366 51.8 µM -0.8595374226025 0.198354818881905 no 2738 0.195022041381861 3910 3972846 SGTC_2070 5230947 200 µM -0.859917104826029 0.198245842694145 no 2739 0.194917369488743 3986 2835538 SGTC_2363 9053361 176 µM -0.860221585077712 0.198158477052471 no 2740 0.194833454180346 3979 6469797 YMR079W SEC14 SGTC_3177 9107506 49.47 µM -0.860350954574318 0.19812136362298 no 2741 0.194797806365213 3837 8897194 SGTC_1269 0831-0796 3.05 µM -0.861585577316162 0.197767387112179 no 2742 0.194457805214149 3964 927758 SGTC_1494 4358-1428 177 µM -0.864683204480734 0.196880955645083 no 2743 0.193606345197126 3927 1564571 SGTC_924 2046-0044 21.3 µM -0.86721885503891 0.196157135601134 no 2744 0.192911053600988 3927 3623589 SGTC_1157 4092-0394 27.6 µM -0.86803208809838 0.19592533446848 no 2745 0.192688383298114 4027 3659885 SGTC_1121 fusaric acid 630.51 nM -0.86828375668275 0.195853633415906 no 2746 0.192619506080983 3918 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_929 2805-0021 398 µM -0.868673912501552 0.195742508462121 no 2747 0.192512757120212 3992 3098024 SGTC_14 0354-0009 295 µM -0.869447519051193 0.19552228151455 no 2748 0.192301200724913 4005 1713507 SGTC_1118 chelidonine 707.474 nM -0.869476004285445 0.195514175335223 no 2749 0.192293413648839 3900 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.86948089506636 0.195512783562841 no 2750 0.192292076663855 3911 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_50 0929-0078 56.389 µM -0.870156651909295 0.195320540894459 no 2751 0.192107400758774 3811 1377751 SGTC_645 0845-0943 5.41 µM -0.872090168291745 0.194771119262455 no 2752 0.191579594640844 3935 1885106 SGTC_2836 9010338 19.48 µM -0.872100367993132 0.194768223443916 no 2753 0.191576812711119 3940 2994051 SGTC_424 splitomicin 100 mM -0.872211246356439 0.194736745425868 no 2754 0.191546572656271 4028 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.872449688607117 0.194669062906731 no 2755 0.191481551780147 3930 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2524 avocatin b 10.57 µM -0.874929785721788 0.193965929145448 no 2756 0.190806055584646 3892 6710748 SGTC_2432 5630864 12.22 µM -0.876113181020558 0.193630970163 no 2757 0.190484253897676 3984 5714970 SGTC_1443 4112-3303 14 µM -0.87668819972907 0.1934683390508 no 2758 0.190328008949664 3955 704433 SGTC_3053 9095903 49.47 µM -0.877742044750972 0.193170499062501 no 2759 0.190041861009314 4036 17174018 SGTC_2162 5663267 200 µM -0.8778511817014 0.193139670540582 no 2760 0.190012242439029 3903 6456493 SGTC_1216 1165-0504 9.65 µM -0.878101117671285 0.193069081052115 no 2761 0.189944423250532 3961 6304004 SGTC_2254 7938975 95.19 µM -0.878722295114162 0.192893709964398 no 2762 0.189775933540713 4002 2969277 SGTC_1978 st071761 42 µM -0.879209860979818 0.192756128335517 no 2763 0.189643749371469 3966 5147680 SGTC_2736 butenafine 14.65 µM -0.880412102480147 0.192417135389096 no 2764 0.189318051303044 3884 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_884 0851-0618 334 µM -0.882235950109003 0.191903566239134 no 2765 0.188824612400657 3969 9642473 SGTC_2232 chlorophetanol 41.5365 µM -0.882454243699224 0.191842154190016 no 2766 0.188765606589561 4007 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2807 7945238 51.95 µM -0.88357971132971 0.191525719858001 no 2767 0.188461567625728 4009 17148797 SGTC_3216 9129716 49.47 µM -0.886251847604672 0.190775708969688 no 2768 0.187740915185734 3922 8056934 SGTC_2943 9068529 45.32 µM -0.888292511037551 0.190204154356407 no 2769 0.187191713515037 3946 3270634 SGTC_2600 tangeritin 87.95 µM -0.890956080189127 0.189459719307305 no 2770 0.186476366328684 3896 68077 A bioactive flavone. SGTC_2304 7443016 91.4 µM -0.892433382498453 0.189047605453557 no 2771 0.186080342397882 3890 939854 SGTC_3098 9119039 49.47 µM -0.892565435149742 0.189010794448103 no 2772 0.186044968132622 3946 17161528 SGTC_2757 clomiphene 4.22 µM -0.892609716513076 0.188998451561047 no 2773 0.186033106974089 4032 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2641 levomentholum 100 µM -0.893588991893267 0.188725617474315 no 2774 0.18577091915317 3919 16666 SGTC_1334 1486-0610 236 µM -0.894755381596213 0.188400968766944 no 2775 0.18545893323934 4039 3742339 SGTC_1477 0139-0234 16 µM -0.895347637163083 0.188236254426462 no 2776 0.1853006412907 3976 620880 SGTC_999 SEC7.066 22.7 µM -0.897498848209542 0.187638721184156 no 2777 0.184726393867756 3953 740511 YDR170C SEC7 SGTC_1090 efavirenz 20.7 µM -0.89751051409016 0.187635483997437 no 2778 0.184723282779659 4005 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2648 atorvastatin 78.68 µM -0.899125888031845 0.187187564131819 no 2779 0.184292805131303 3975 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_346 4513-0042 7.16 µM -0.899370642866097 0.187119754882107 no 2780 0.184227635422122 3957 2827372 SGTC_2622 2-methoxyxanthone 59.94 µM -0.899396866254117 0.18711249060193 no 2781 0.184220653895666 3984 71034 A hepatoprotective. SGTC_3266 9136860 49.47 µM -0.899565822934046 0.187065691195912 no 2782 0.184175676031009 3844 4871271 YPR165W RHO1 SGTC_2778 tioconazole 65.09 nM -0.903565207347124 0.185960014508721 no 2783 0.183112998595981 3882 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3099 9120367 49.47 µM -0.906072653233699 0.185268872785809 no 2784 0.182448699356407 3995 24824940 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.90623495113748 0.18522419271207 no 2785 0.182405753607375 4010 5024745 SGTC_3081 9117243 49.47 µM -0.907095459595522 0.184987409403555 no 2786 0.182178159455126 3988 45595589 SGTC_1570 verbenone 133 µM -0.907733069932171 0.1848120816097 no 2787 0.182009633718287 4010 29025 A natural terpanoid with antifungal properties. SGTC_1612 st002233 45.4 µM -0.907994043445394 0.184740349852144 no 2788 0.181940684362033 3973 1035021 SGTC_3008 9078912 71.4286 µM -0.910950092530801 0.183929052412783 no 2789 0.181160835160277 3967 16648731 SGTC_1411 3909-8223 150 µM -0.91148258812378 0.183783143422822 no 2790 0.181020577876569 3994 X1411 SGTC_1078 idebenone 36.1 µM -0.911773816695745 0.183703374460458 no 2791 0.180943898184222 4036 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.912233973109147 0.18357737929381 no 2792 0.180822781747001 3982 5106787 A p450 inhibitor. SGTC_900 1112-0045 141 µM -0.914738541628729 0.182892549452427 no 2793 0.180164452880661 3884 56211 YIL048W NEO1 SGTC_2275 7947463 200 µM -0.914924009038997 0.182841900163755 no 2794 0.180115762449951 3976 1225414 SGTC_209 4077-0173 175.592 µM -0.914961708804053 0.182831605806993 no 2795 0.180105866207727 3960 15993494 SGTC_1760 st045453 10.4495 µM -0.915678842821378 0.182635852969954 no 2796 0.179917682510857 4037 3323419 YIL048W NEO1 SGTC_1008 4106-0037 6 µM -0.918286592512866 0.181925131126521 no 2797 0.179234422339994 3932 2905394 SGTC_234 nsc-17383 10.7 µM -0.919875986974758 0.181492803604979 no 2798 0.178818784367487 3978 408974 SGTC_2058 5236698 133 µM -0.920549568153898 0.181309778524804 no 2799 0.17864282128618 4000 766665 SGTC_1151 3909-8316 15.3 µM -0.922170420761793 0.180869835292328 no 2800 0.178219844659472 4044 800431 SGTC_444 curcumin 90.4 µM -0.922255638310945 0.180846723473432 no 2801 0.178197623823202 3956 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_656 4090-1979 187 µM -0.9230795162283 0.180623375326854 no 2802 0.17798288423123 4060 22330961 SGTC_1610 st001799 48.1 µM -0.92455690849724 0.180223296955523 no 2803 0.177598218302154 3909 621897 SGTC_918 glabranin 770.725 nM -0.924714059875745 0.180180773055831 no 2804 0.177557331978896 4017 124049 Also referred to as licorice root. SGTC_1068 loratadine 26.9 µM -0.925372068723138 0.180002789551001 no 2805 0.177386201293636 4037 3957 A H1 histamine antagonist. SGTC_350 k064-0020 19.8 µM -0.926608030784422 0.179668775176557 no 2806 0.17706504188037 4011 2790705 SGTC_2175 5807670 165.306 µM -0.926742693259589 0.179632406661486 no 2807 0.17703007262291 3994 241186 SGTC_1501 4491-0275 38.4 µM -0.92891232530603 0.179047088409314 no 2808 0.176467262470425 3927 5104718 SGTC_805 3852-0218 479 µM -0.929352605277076 0.178928457333134 no 2809 0.176353190596922 3947 6615355 SGTC_1025 k007-0731 70 µM -0.92982916872456 0.178800105631361 no 2810 0.176229770652286 3971 6256118 SGTC_1448 4255-0083 152 µM -0.930169361917771 0.178708517669414 no 2811 0.176141701192317 4078 5399660 SGTC_853 0419-0306 21 µM -0.930500510943428 0.178619392985001 no 2812 0.17605599985571 4027 762713 SGTC_2596 sinensetin 100 µM -0.930763983799026 0.178548502506766 no 2813 0.17598783196629 4034 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_164 4100-3994 89.624 µM -0.93120228011253 0.178430612980165 no 2814 0.175874469328276 3941 4615967 SGTC_1150 3909-7983 10.9 µM -0.932815591491799 0.177997099633536 no 2815 0.175457594824053 3982 23965914 SGTC_18 0111-0177 500 nM -0.933530550105161 0.177805195462474 no 2816 0.175273052260872 4059 721752 SGTC_2896 9052656 71.43 µM -0.934003704443441 0.177678266490744 no 2817 0.175150991059022 3885 6469436 SGTC_108 0509-0257 621.132 µM -0.934114193319439 0.177648634843446 no 2818 0.175122495642432 3980 536624 SGTC_2110 5483698 200 µM -0.935473163375205 0.177284432221118 no 2819 0.174772253683653 3997 2848765 YHR062C RPP1 SGTC_395 anisomycin 6.25 µM -0.937736476254324 0.176678914026958 no 2820 0.17418992674459 4038 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1246 0422-0085 105 µM -0.939515046715387 0.176204000672397 no 2821 0.173733185283611 4063 264295 SGTC_256 clotrimazole 625 nM -0.939568330728494 0.17618978526747 no 2822 0.173719513576557 3943 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1310 1188-0297 994 nM -0.940722096011532 0.175882155393915 no 2823 0.173423646294788 3910 1588352 SGTC_3138 9097216 49.47 µM -0.944561788542167 0.174860825110936 no 2824 0.172441321447957 3994 25237486 SGTC_2376 9072922 81.32 µM -0.945105181002691 0.174716591304583 no 2825 0.172302590264215 4067 17087968 SGTC_2310 7668677 200 µM -0.946882147233915 0.174245454939234 no 2826 0.171849418025371 4041 2197143 SGTC_3087 9117406 49.47 µM -0.948484485386896 0.173821311528041 no 2827 0.171441433678155 4062 42546093 SGTC_1153 4055-0057 267 µM -0.94885868088568 0.17372235558709 no 2828 0.171346245955978 4075 882706 SGTC_1970 st070122 35.8 µM -0.952507183390665 0.172759388535063 no 2829 0.170419912304525 4066 102928 SGTC_1822 st052468 42 µM -0.95492833969227 0.172122242713689 no 2830 0.169806968550794 4041 2873678 SGTC_1865 st057639 52.2 µM -0.954984387415329 0.172107511109121 no 2831 0.169792796182644 4017 688818 SGTC_1047 2043-3044 82 µM -0.955291008916667 0.172026932843008 no 2832 0.169715276525287 4030 669592 SGTC_1123 mangostin 811.285 nM -0.959201832493312 0.171001305277202 no 2833 0.168728538752858 4057 5281650 An antioxidant. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.959822724647218 0.170838834616018 no 2834 0.168572221602154 4040 6857784 SGTC_2010 4012422 159 µM -0.960195591727902 0.170741312887727 no 2835 0.1684783925363 4036 952393 SGTC_2873 9040596 71.43 µM -0.960240534432942 0.170729560729518 no 2836 0.168467085326478 4041 6463863 SGTC_1725 st036284 20.55 µM -0.960555554445768 0.1706472000473 no 2837 0.168387842615444 4142 707914 SGTC_1871 st057448 67.3 µM -0.960653002516497 0.17062172780308 no 2838 0.168363334585785 4088 691747 SGTC_2486 5283202 22.39 µM -0.964156197442236 0.169707634063274 no 2839 0.167483810641175 4099 1377751 SGTC_2319 6033012 152.6 µM -0.967216799785968 0.168911602365146 no 2840 0.166717832790619 4004 847246 SGTC_504 lovastatin 124 µM -0.968520980777284 0.168573128117997 no 2841 0.166392122959047 4070 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3057 9095946 49.47 µM -0.971073897200848 0.167911832477548 no 2842 0.165755740588364 4077 24540043 SGTC_258 haloperidol 50.781 µM -0.97129629740832 0.167854302139853 no 2843 0.16570037602629 4068 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2047 4141938 200 µM -0.973657813924932 0.167244209514299 no 2844 0.165113235067214 4053 3807862 SGTC_309 k408-0051 1.48 µM -0.975429087155337 0.166787544263865 no 2845 0.164673730592737 4003 3640463 SGTC_3190 9110366 49.47 µM -0.975587484346976 0.166746745919116 no 2846 0.164634464592574 4059 17123768 SGTC_325 2810-4341 181 µM -0.975901699957278 0.166665832502084 no 2847 0.164556589815123 4061 774970 SGTC_1184 1269-1718 139 µM -0.976477853128505 0.166517533584431 no 2848 0.164413858810272 4138 5403821 SGTC_2502 avocadyne acetate 18.59 µM -0.976789147805278 0.166437443361855 no 2849 0.164336774871132 3994 3952079 SGTC_887 0885-0007 9.62 µM -0.977088302704337 0.16636049991254 no 2850 0.164262719110872 4143 5719458 SGTC_3112 9123419 49.47 µM -0.98849013695515 0.163445044426721 no 2851 0.161456331248302 4115 17015854 SGTC_1657 st012939 43.4 µM -0.993278953322013 0.162230497732296 no 2852 0.160287015631915 4103 24207257 SGTC_889 0919-1524 82.7 µM -0.996365862926407 0.161450713883294 no 2853 0.159536206556541 4120 3905452 SGTC_2168 5727979 200 µM -0.997276118381865 0.161221241749605 no 2854 0.159315251193645 3982 695210 SGTC_178 4092-0806 87.505 µM -0.997478611467449 0.161170222914821 no 2855 0.159266125293015 3979 2169044 SGTC_1178 0988-0033 191 µM -0.998724274961568 0.160856605417151 no 2856 0.158964138943817 4139 5392207 SGTC_2713 st079149 53.4 µM -0.998859898816162 0.160822483813742 no 2857 0.158931282301391 4114 3103253 SGTC_3342 9147791 14.508 µM -1.00085104656936 0.160322075005752 no 2858 0.15844941320377 3985 1838168 SGTC_2280 7785178 200 µM -1.00133316816637 0.160201062955529 no 2859 0.158332881296075 4080 2954328 SGTC_2131 toluylene red 5.2905 µM -1.00258896128332 0.159886140493197 no 2860 0.158029612024145 4085 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_625 k213-0058 121 µM -1.00377614454574 0.159588796323793 no 2861 0.157743262658398 4157 3655420 SGTC_743 1275-0778 158 µM -1.00390769389952 0.159555870510859 no 2862 0.157711553857839 4085 2849257 YMR203W TOM40 SGTC_3132 9126706 49.47 µM -1.00552226119831 0.159152118670288 no 2863 0.157322717862822 4183 850858 SGTC_336 4111-0029 111 µM -1.0059981177402 0.159033249910182 no 2864 0.1572082377508 4098 3131175 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.00757837023787 0.158638920954947 no 2865 0.156828458522398 4085 390807 SGTC_1057 3448-5381 134 µM -1.00917993043589 0.158239929671756 no 2866 0.156444174942236 4092 5497911 SGTC_2094 5332512 191.667 µM -1.00986945089955 0.158068354727038 no 2867 0.156278920263332 4130 755774 SGTC_285 1486-1325 46 µM -1.01327624142549 0.15722242819541 no 2868 0.155464116258996 4151 22310230 SGTC_1458 k015-0034 6.33 µM -1.01352469070384 0.15716085342056 no 2869 0.155404804360918 4132 3598957 SGTC_3145 9085516 49.47 µM -1.01465617719965 0.156880630472008 no 2870 0.155134875271039 4145 25236195 SGTC_2286 7945697 125 µM -1.01499091161368 0.156797793494311 no 2871 0.155055079901476 4137 1245733 SGTC_2938 9059746 27.26 µM -1.01584758775214 0.156585922326364 no 2872 0.154850985367742 4104 6471769 SGTC_3077 9117319 49.47 µM -1.01597637401496 0.156554087509013 no 2873 0.154820318677929 4077 17154678 SGTC_1677 st019204 53.9 µM -1.01630770419979 0.156472205222522 no 2874 0.154741440503958 4129 3945625 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.01817132418441 0.156012170606218 no 2875 0.154298272269037 4066 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2630 antimycin a 100 µM -1.01947261483079 0.155691476058231 no 2876 0.153989323884516 4056 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_660 4031-1742 102 µM -1.025481960416 0.154216155372712 no 2877 0.152567916511839 4007 6738706 SGTC_1870 st057514 26.5 µM -1.02699630881949 0.15384583957214 no 2878 0.152211101090905 4106 5393161 SGTC_591 4299-0174 154 µM -1.02742052996691 0.153742206977294 no 2879 0.152111244227751 4129 5509088 SGTC_3269 9137823 49.47 µM -1.0284285854928 0.153496135434798 no 2880 0.151874133899391 4031 17682936 SGTC_903 1134-0042 114 µM -1.03127052073669 0.152803809440626 no 2881 0.151206989202565 4145 701009 SGTC_139 0099-0334 718.624 µM -1.03140077627451 0.152772127502041 no 2882 0.151176458492834 4156 97690 SGTC_2904 7225135 42.03 µM -1.03173238227137 0.152691490935471 no 2883 0.151098751583933 4227 4446116 SGTC_597 k018-0003 82.8 µM -1.03189957550723 0.152650845296226 no 2884 0.151059582427784 4185 6786234 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.03256461570009 0.152489241254927 no 2885 0.150903847185961 4110 140250 A respiratory chain inhibitor. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.03282678914569 0.152425564604684 no 2886 0.150842482314159 4101 688667 SGTC_1908 st060353 56.5 µM -1.03527688076079 0.151831339845741 no 2887 0.150269811771491 4193 4227716 SGTC_3349 9149703 23.001 µM -1.03596097859863 0.151665699720288 no 2888 0.150110173711192 4145 4910494 SGTC_379 3970-0972 5.9 µM -1.03831045274588 0.151097738086696 no 2889 0.149562771928748 4138 2898042 YBL034C STU1 SGTC_2533 agelasine 13.65 µM -1.03959207845303 0.15078851533224 no 2890 0.149264729384921 4198 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_653 0203-0016 55.2 µM -1.0406330772891 0.150537659849164 no 2891 0.149022936784973 4178 295302 SGTC_2760 etidronate 98.04 µM -1.04167218904284 0.150287536484875 no 2892 0.148781843577418 4086 3305 A chelator and antioxidant. SGTC_3325 9138760 55.175 µM -1.04176168647953 0.150266006623976 no 2893 0.148761090711325 4067 43844959 SGTC_2234 tolnaftate 200 µM -1.04223672126341 0.15015176476977 no 2894 0.148650970970386 4168 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3024 9090631 49.47 µM -1.04261505523049 0.150060820072739 no 2895 0.14856330683077 4112 25236383 SGTC_2378 9074213 121.43 µM -1.04389726949899 0.149752871959591 no 2896 0.148266460819931 4104 657714 SGTC_248 streptozotocin 5.23457 mM -1.0443545613476 0.149643146693898 no 2897 0.148160689034085 4162 5300 DNA alkylating agent. SGTC_2892 9047358 58.44 µM -1.05203115699111 0.14780918885663 no 2898 0.146392627536251 4155 6466771 SGTC_1155 4088-0394 48.2 µM -1.05727192852164 0.146565835501068 no 2899 0.145193750418964 4109 2326248 SGTC_2572 astragaloside iv 100 µM -1.05793842645061 0.146408215977259 no 2900 0.145041757467845 4200 45006101 An anti-inflammatory agent. SGTC_1205 4161-2785 76 µM -1.05801332208327 0.146390511088455 no 2901 0.145024684428522 4219 3498106 SGTC_2881 9058953 51.95 µM -1.05973500934739 0.145983910622626 no 2902 0.144632585456002 4105 17122249 SGTC_2634 4'-methoxyflavone 100 µM -1.05990228869297 0.145944445755021 no 2903 0.144594527170047 4172 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2504 purpurogallin 52.29 µM -1.05996336746628 0.145930037719224 no 2904 0.144580632614675 4053 5281571 An antioxidant. SGTC_1167 k781-0610 148 µM -1.06197722589648 0.145455518526008 no 2905 0.14412301209511 4191 4525169 SGTC_3120 9124077 49.47 µM -1.06416948028027 0.144940145445348 no 2906 0.143625965035894 4277 18774327 YGL155W CDC43 SGTC_819 1013-0258 27.7 µM -1.06514199140394 0.144711913699404 no 2907 0.143405839705495 4161 5753198 SGTC_3236 9132701 49.47 µM -1.06520555990225 0.14469700369167 no 2908 0.143391459078996 4147 24282524 SGTC_2185 6113692 200 µM -1.06542858117648 0.144644702177241 no 2909 0.143341014342831 4164 874150 SGTC_1218 1348-1416 30.7 µM -1.06624583941743 0.144453152876449 no 2910 0.143156262761246 4104 6787668 SGTC_2863 9028737 58.44 µM -1.0672613434685 0.14421537690433 no 2911 0.14292691941012 4137 6460917 SGTC_1964 st076914 61 µM -1.06874857247128 0.143867624956153 no 2912 0.142591489131171 4200 24208661 SGTC_2334 9017922 200 µM -1.07359650548432 0.142737984864952 no 2913 0.141501782255961 4225 3163164 SGTC_3283 9109332 35.8195 µM -1.07420053934914 0.142597657299971 no 2914 0.141366405359408 4005 17027281 SGTC_1583 clindamycin 39.6 µM -1.07778503999114 0.141766835265155 no 2915 0.140564848619303 4141 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1368 1852-0141 284 µM -1.07885674885896 0.141519070556951 no 2916 0.140325796111642 4192 2838987 SGTC_370 0180-0345 38.7 µM -1.07968029899674 0.141328876294507 no 2917 0.140142284924753 4032 3989527 SGTC_430 0958-0115 16.4 µM -1.08092804749035 0.141041046059294 no 2918 0.139864560616325 4128 6833180 SGTC_669 0108-0021 26.2 µM -1.08178896725824 0.14084268129471 no 2919 0.13967315502783 4072 17201 SGTC_1665 st014639 11.4 µM -1.08771876038581 0.139481538584683 no 2920 0.138359641564852 4228 981133 YIL048W NEO1 SGTC_2221 6807166 181.081 µM -1.08980428933651 0.139004953770413 no 2921 0.137899682053494 4150 674925 SGTC_2987 9018338 71.43 µM -1.09005187807567 0.138948448527471 no 2922 0.137845146169153 4213 5055682 SGTC_1185 1319-0113 81.3 µM -1.09121849316166 0.138682411550023 no 2923 0.137588376187963 4258 4672763 SGTC_1917 st066507 28.5 µM -1.09145714092793 0.138628032666942 no 2924 0.137535890473067 4139 3156428 SGTC_1114 scopoletin 1.73284 µM -1.09319395270955 0.138232715912931 no 2925 0.137154325806275 4220 5280460 A coumarin with genotoxic properties. SGTC_2956 9076196 2.52 µM -1.09334028655904 0.138199443918974 no 2926 0.13712221040771 4204 16423868 SGTC_3144 9087057 49.47 µM -1.09645421031179 0.137492723865912 no 2927 0.136440025721837 4092 17249618 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.09661808003244 0.137455601300311 no 2928 0.136404190278748 4227 279621 SGTC_412 gemfibrozil 100 µM -1.09686521673431 0.137399628620606 no 2929 0.136350157980794 4111 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2621 lithochol-11-enic acid 100 µM -1.09831036349685 0.137072636603834 no 2930 0.136034494040608 4152 6708711 SGTC_1503 4585-0012 61.3 µM -1.1029508222688 0.136026241052858 no 2931 0.135024260997405 4236 2922052 SGTC_307 1501-1223 22.3 µM -1.10352194860552 0.135897834433734 no 2932 0.134900282685161 4231 2830329 SGTC_98 0074-0023 107.663 µM -1.10717696129621 0.135078041492437 no 2933 0.13410871315162 4218 3563821 SGTC_365 0121-0052 13.6 µM -1.10835316296562 0.134814950721364 no 2934 0.133854662067649 4227 3101739 SGTC_3270 9137563 49.47 µM -1.10837573029969 0.134809906338609 no 2935 0.133849790922469 4180 17015724 SGTC_971 1315-0384 26.7 µM -1.10946027972338 0.134567634144968 no 2936 0.13361583521593 4241 6769120 SGTC_1437 4092-1038 11.6 µM -1.10970194391711 0.134513690703624 no 2937 0.133563742481806 4229 3977136 SGTC_60 0986-0278 202 µM -1.11062908084093 0.134306876151846 no 2938 0.133364019961706 4160 3110598 SGTC_638 3970-0837 4.09 µM -1.11074264604343 0.134281558412859 no 2939 0.133339570038706 4177 4118451 YLR208W SEC13 SGTC_648 0375-0473 33.3 µM -1.1139480503521 0.133568310972469 no 2940 0.132650736948511 4177 1713139 SGTC_26 0302-0163 425.158 µM -1.11975447005481 0.132282944863618 no 2941 0.131409203091917 4269 3100915 SGTC_2122 5258151 111.688 µM -1.12233417468595 0.131714620547463 no 2942 0.130860190411285 4216 2173356 SGTC_345 1362-0200 395 µM -1.1224365347602 0.131692104817922 no 2943 0.130838438888648 4203 1419823 SGTC_2407 paclitaxel 400 µM -1.12459842812549 0.131217182279406 no 2944 0.130379620058286 4314 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_677 0929-0063 136 µM -1.12586735334073 0.130938977643763 no 2945 0.130110834873935 4207 1539583 SGTC_2117 5521686 200 µM -1.12590869354998 0.130929920898882 no 2946 0.13010208459864 4178 803312 SGTC_1232 0279-0259 161 µM -1.127446535788 0.130593320490091 no 2947 0.129776866562316 4215 1560000 SGTC_2882 9058044 58.44 µM -1.1276337220484 0.130552390350076 no 2948 0.129737319466451 4257 18076804 SGTC_2846 9008642 19.48 µM -1.12799670724482 0.130473045303316 no 2949 0.129660654875807 4266 2992898 SGTC_3331 9141060 1.957 µM -1.13030842551553 0.129968508660578 no 2950 0.129173142763405 4179 4906567 YPR165W RHO1 SGTC_1342 1486-1464 234 µM -1.1325554772861 0.129479381581715 no 2951 0.128700487304116 4246 3253938 SGTC_38 0929-0051 58.268 µM -1.13414847583218 0.129133399081442 no 2952 0.128366136236131 4214 1379719 SGTC_2567 aureobasidin a 60 nM -1.1348446053657 0.128982408506283 no 2953 0.128220216600879 4373 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1843 st055809 45.5 µM -1.13542488014245 0.128856640439801 no 2954 0.128098669995438 4286 16413835 SGTC_970 1315-0089 19.5 µM -1.13618036800522 0.128693024402708 no 2955 0.127940542539705 4180 6811083 YLR033W RSC58 SGTC_2975 9084847 53.72 µM -1.13632556945236 0.128661594641457 no 2956 0.127910166682213 4282 27211724 SGTC_3319 9138450 16.7555 µM -1.13728920830211 0.1284531439546 no 2957 0.127708702311467 4165 2029690 SGTC_3297 9117502 71.43 µM -1.14016305707241 0.127832876477092 no 2958 0.12710918766124 4247 7453720 SGTC_2675 theaflavin digallate 100 µM -1.15042157160435 0.125635754089914 no 2959 0.124985139797853 4178 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1984 st072354 53.1 µM -1.15336419469904 0.125010408072785 no 2960 0.124380465689377 4128 5762938 SGTC_2019 4016004 108 µM -1.15383920036604 0.124909667301074 no 2961 0.124283049757772 4282 45595336 SGTC_2659 sanguinarine 24.21 µM -1.15651756230509 0.124342693011944 no 2962 0.123734760116235 4192 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_870 0573-2213 57.6 µM -1.16146732868577 0.123299633994328 no 2963 0.122725951090631 4236 3916321 SGTC_1885 st057546 99.9 µM -1.1628919505698 0.123000564402589 no 2964 0.122436671850045 4277 702008 SGTC_460 trequinsin 123 µM -1.16494799252519 0.12256983855539 no 2965 0.122020022612078 4326 5537 A vasodilator. SGTC_2942 9052777 62.25 µM -1.16682803301609 0.122176910956298 no 2966 0.121639911852108 4316 6469503 SGTC_2916 7875993 68.79 µM -1.16721533430459 0.12209607514705 no 2967 0.121561709902571 4092 1299250 SGTC_2260 7964312 200 µM -1.16723086942127 0.122092833509918 no 2968 0.121558573866403 4310 231951 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.16869520604323 0.121787548808173 no 2969 0.121263227062678 4270 115019 SGTC_2289 7946404 165.07 µM -1.16923144817234 0.121675887395121 no 2970 0.121155196990592 4253 1246120 YPR165W RHO1 SGTC_495 decylubiquinone 155 µM -1.17129784704985 0.121246275102745 no 2971 0.120739538262512 4291 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_808 0711-0032 135 µM -1.17199920692986 0.121100702454344 no 2972 0.120598687279247 4238 4252555 SGTC_2806 7952793 58.44 µM -1.17207641110772 0.121084685647347 no 2973 0.12058318977915 4315 2972490 SGTC_1749 st037932 54.2 µM -1.17227283158706 0.121043942901687 no 2974 0.120543767841281 4295 594497 SGTC_2893 9048488 25.97 µM -1.17229172788522 0.121040023823755 no 2975 0.120539975799382 4312 6467338 SGTC_2366 9070441 60.58 µM -1.17360485749561 0.12076790035666 no 2976 0.120276667331195 4237 6837235 SGTC_1710 st031758 61.5 µM -1.17473496572875 0.120534049929566 no 2977 0.120050382915418 4299 5394341 SGTC_487 nimodipine 119 µM -1.17521035507089 0.120435774159815 no 2978 0.119955284222042 4233 4497 L-type voltage-gated calcium channels inhibitor SGTC_314 1671-0008 2.74 µM -1.17660242794565 0.120148319863519 no 2979 0.119677114129857 4150 3913060 SGTC_2242 6630449 61.2675 µM -1.17713452961315 0.120038572033728 no 2980 0.11957090752085 4314 691249 YDR170C SEC7 SGTC_1055 3448-0672 86 µM -1.17742277465028 0.119979149999498 no 2981 0.119513402060983 4261 748378 SGTC_732 3970-1727 52.7 µM -1.17772236885028 0.119917410300741 no 2982 0.119453653101289 4339 1275699 SGTC_956 1185-0240 191 µM -1.1801102288218 0.119426126063784 no 2983 0.11897818843343 4249 1416193 SGTC_120 rhodamine 6G 52.259 µM -1.18059225299195 0.119327125731046 no 2984 0.118882371329878 4271 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_404 fumagillin 50 µM -1.18111206587411 0.11922042909898 no 2985 0.118779103648558 4271 12015870 A methionine aminopeptidase binder. SGTC_2391 6285546 200 µM -1.18222809376941 0.118991581089082 no 2986 0.118557604103181 4268 846083 SGTC_990 3985-0011 41.3 µM -1.18286088993773 0.118861960442223 no 2987 0.118432141955981 4244 5399565 YGL099W LSG1 SGTC_965 1291-5240 308 µM -1.18513729015274 0.118396492146931 no 2988 0.117981584659964 4292 2834598 SGTC_2109 5483026 200 µM -1.18523406732257 0.118376732170711 no 2989 0.117962456912301 4288 759335 SGTC_2868 9035608 32.47 µM -1.18628207635497 0.118162898845505 no 2990 0.117755461244105 4256 6462614 SGTC_206 4546-0025 72.014 µM -1.18869410214244 0.117671792896341 no 2991 0.117280031160151 4325 6620745 YIL048W NEO1 SGTC_123 0083-0120 66.675 µM -1.19027480985007 0.117350733988724 no 2992 0.116969199084581 4252 16001701 SGTC_1065 prochlorperazine maleate 2.48 µM -1.19056801975835 0.117291248146178 no 2993 0.116911606221285 4318 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_661 1304-0007 33.6 µM -1.1910941287478 0.117184565749001 no 2994 0.11680831725651 4274 3117130 SGTC_835 0312-0010 67.2 µM -1.19126143204579 0.117150655026731 no 2995 0.116775484800592 4277 1626196 SGTC_2858 9025781 8.96 µM -1.1913408394337 0.117134562368441 no 2996 0.116759903777902 4159 4894980 YPL153C RAD53 SGTC_2553 4-methylesculetin 85.09 µM -1.19212353546784 0.116976025408227 no 2997 0.116606404925909 4302 5319502 SGTC_1296 1068-0102 11.9 µM -1.19289509858071 0.116819892340892 no 2998 0.116455229531437 4265 767053 SGTC_3165 9101544 49.47 µM -1.19355673383825 0.116686121914276 no 2999 0.116325703501465 4280 5002184 SGTC_255 tunicamycin 200.472 nM -1.19393535902003 0.116609619775623 no 3000 0.116251627367099 4202 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2979 9012552 45.46 µM -1.19499251851826 0.116396206444543 no 3001 0.11604497658869 4288 17100905 SGTC_2734 clemastine 41.6 µM -1.19539876217451 0.11631427003315 no 3002 0.115965634536659 4329 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1953 st076800 12.1 µM -1.19958043515253 0.115473234870297 no 3003 0.115151164375385 4274 297591 SGTC_1802 st050112 57.9 µM -1.20220073448213 0.114948436841674 no 3004 0.114642882415321 4284 4662563 SGTC_1859 st055998 20 µM -1.20329985564816 0.114728808758585 no 3005 0.11443015245858 4256 676301 SGTC_2804 7954240 19.48 µM -1.20611378675594 0.114167885885232 no 3006 0.113886809832287 4306 828705 SGTC_3080 9117754 49.47 µM -1.20660231492936 0.11407070307475 no 3007 0.113792667412381 4294 9550191 SGTC_689 0833-0039 98 µM -1.20836307623105 0.113720924178931 no 3008 0.113453817982799 4241 5374726 SGTC_3113 9123498 49.47 µM -1.2133056089249 0.112743166621166 no 3009 0.112506499628081 4402 8897275 SGTC_3348 9149464 3.537 µM -1.21411551817667 0.112583520285239 no 3010 0.11235180747695 4234 1951442 SGTC_479 n-linoleoylglycine 10 µM -1.2157242238707 0.112266897135475 no 3011 0.112044996579208 4343 6433346 An anti-infammatory. SGTC_552 k242-0005 476 µM -1.21881023538022 0.111661295083318 no 3012 0.111458112883804 4372 4088318 SGTC_3054 9094397 49.47 µM -1.22131441088023 0.111171593583277 no 3013 0.110983499579672 4296 2598354 SGTC_2815 7968870 71.43 µM -1.22462064138028 0.110527405138583 no 3014 0.110359093512594 4249 2977326 YHR190W ERG9 SGTC_320 4092-0846 5.34 µM -1.22483466802497 0.110485796432546 no 3015 0.110318759985181 4260 1359356 SGTC_182 3448-4371 550.524 µM -1.2248371356454 0.110485316770415 no 3016 0.110318295021382 4170 3491403 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.22941887602034 0.109597279869842 no 3017 0.109457398306838 4322 2374 Ca(2+)-ATPase inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM -1.2299516738565 0.109494346119113 no 3018 0.109357601060304 4331 270010 SGTC_3014 9081533 49.47 µM -1.23381913249483 0.108749253979108 no 3019 0.108635154209941 4357 21367265 SGTC_1198 1612-1005 86.7 µM -1.23811570834335 0.107925772697359 no 3020 0.107836580071392 4390 6998509 SGTC_1297 1068-0111 14.1 µM -1.2387356170866 0.107807332730005 no 3021 0.107721711950758 4310 767057 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.24425907710664 0.106756150377974 no 3022 0.106702113572826 4370 368090 SGTC_528 3492-0019 172 µM -1.24836084651917 0.105980333087715 no 3023 0.105949470342487 4328 2869262 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.25246446645201 0.105208250910546 no 3024 0.10520033420196 4318 803109 SGTC_3206 9114350 49.47 µM -1.25282378922387 0.105140839848647 no 3025 0.105134921014263 4193 17087243 SGTC_27 0485-0001 32.618 µM -1.25409401896412 0.104902787860362 no 3026 0.104903917030987 4312 2054479 SGTC_2479 5617353 43.85 µM -1.255175369494 0.104700441156558 no 3027 0.1047075523758 4348 2731746 SGTC_1630 st005209 31.3 µM -1.25530572433072 0.104676067735038 no 3028 0.104683898965642 4319 3367314 SGTC_879 0831-1030 162 µM -1.25556168183214 0.104628221398467 no 3029 0.104637465706349 4338 1549252 SGTC_2220 6782180 200 µM -1.25668043462892 0.104419277997411 no 3030 0.104434687822866 4252 833803 SGTC_1361 1608-0041 5.61 µM -1.25716614402509 0.104328658872652 no 3031 0.104346739984785 4306 X1361 SGTC_516 3992-2719 87.3 µM -1.25728655673444 0.104306202212206 no 3032 0.104324945051911 4229 5350887 YDR037W KRS1 SGTC_1801 st050089 28.441 µM -1.25825999538057 0.104124787036604 no 3033 0.10414887191108 4372 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2756 carbadox 75.1 µM -1.26136973062549 0.103546773161469 no 3034 0.103587834365109 4272 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1324 1418-0026 34.4 µM -1.26354328469979 0.103144154387908 no 3035 0.103197000608039 4383 1372513 SGTC_153 4077-0274 519.67 µM -1.26591995054009 0.102705214732304 no 3036 0.102770871465156 4386 3121976 SGTC_204 PMA1.184 62.41 µM -1.26894317738851 0.102148827466739 no 3037 0.102230665574519 4300 2252213 YGL008C PMA1 SGTC_2203 7227154 166.4 µM -1.26899939241768 0.102138502596965 no 3038 0.102220640378258 4361 896304 SGTC_96 0929-0093 37.281 µM -1.27087441889888 0.101794556181433 no 3039 0.101886664173905 4350 6991579 SGTC_2752 diclazuril 33.15 µM -1.27476173346646 0.10108417219254 no 3040 0.101196794442037 4275 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2585 alliin 100 µM -1.2748624413062 0.101065816562743 no 3041 0.101178967477243 4407 87310 A garlic compound which reacts with lipids. SGTC_3073 9114972 49.47 µM -1.27690111914125 0.100694756849893 no 3042 0.100818579497144 4343 41905075 SGTC_227 fluconazole 33.516 µM -1.27829771408653 0.100441136751043 no 3043 0.100572236772832 4348 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_613 3914-0030 117 µM -1.27858392149879 0.100389219399549 no 3044 0.100521807451804 4061 1145395 SGTC_2623 humulene 100 µM -1.28046352366264 0.1000487505263 no 3045 0.100191082687816 4347 6187145 An anti-inflammatory. SGTC_1790 st045711 43.5 µM -1.28440629305632 0.0993373028187825 no 3046 0.099499916094819 4340 585119 SGTC_235 0330-0087 5 mM -1.28476248275565 0.0992732132718158 no 3047 0.0994376481728131 4406 46494818 YHR062C RPP1 SGTC_1944 st076371 56.9 µM -1.28549534075441 0.099141444547903 no 3048 0.0993096219282611 4318 24208455 SGTC_1299 1079-1439 3.74 µM -1.28638618115775 0.0989814427034468 no 3049 0.0991541593639483 4330 323161 SGTC_1617 st002906 78 µM -1.28797496624835 0.0986965535967158 no 3050 0.0988773387951015 4346 5150859 SGTC_101 0490-5701 117.494 µM -1.29200696481295 0.0979762606270243 no 3051 0.098177366311733 4219 4661669 SGTC_581 0958-0271 211 µM -1.29292994256304 0.0978119192568188 no 3052 0.098017645196141 4371 4591145 SGTC_2460 5552655 174.22 µM -1.293481500483 0.0977138077784344 no 3053 0.0979222891431351 4376 5401989 SGTC_2137 5261020 140 µM -1.29526650583926 0.0973967844933439 no 3054 0.0976141546907784 4331 763655 SGTC_1995 st072814 61.1 µM -1.29896539337055 0.0967422518702523 no 3055 0.0969779029214572 4336 5769371 SGTC_1067 clotrimazole 1.36 µM -1.29908912855976 0.0967204124192882 no 3056 0.0969566717752118 4403 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2629 bisabolol 100 µM -1.30326719233989 0.0959851016237329 no 3057 0.0962417787789032 4396 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3115 9123671 49.47 µM -1.30358747992278 0.0959289032983262 no 3058 0.0961871358756407 4510 3286988 SGTC_3093 9117344 49.47 µM -1.30380555522704 0.0958906532015739 no 3059 0.0961499440275933 4372 24824913 SGTC_2761 levamisole 97.89 µM -1.30595371992613 0.095514467515604 no 3060 0.0957841482123528 4372 26879 An alkaline phosphatase inhibitor. SGTC_3198 9112019 49.47 µM -1.30671088219 0.0953821328057754 no 3061 0.0956554607071824 4415 45595555 SGTC_657 3534-0529 86.7 µM -1.30796530936746 0.0951631846441799 no 3062 0.0954425379665205 4404 1049549 SGTC_3044 9093193 49.47 µM -1.30875855666693 0.0950249221396296 no 3063 0.0953080747017108 4390 25236277 SGTC_776 4476-4378 112 µM -1.30924128328941 0.094940855647252 no 3064 0.0952263160551187 4424 2892008 SGTC_1768 st044301 37.178 µM -1.31351674055114 0.0941986783471995 no 3065 0.09450444184755 4378 3931349 SGTC_2820 7989630 71.43 µM -1.3136917273123 0.0941683937929895 no 3066 0.0944749830160422 4397 2984098 SGTC_755 1995-0008 37.3 µM -1.31510400450414 0.0939242371150009 no 3067 0.0942374754778802 4338 689533 SGTC_1377 2944-0135 198 µM -1.31647385066956 0.0936878626372062 no 3068 0.0940075247642275 4380 1894137 SGTC_2149 5554786 194.827 µM -1.3194559943073 0.0931747967442998 no 3069 0.0935083563042774 4415 745063 YPR165W RHO1 SGTC_254 nsc-64875 3.808 µM -1.3196271314928 0.0931454163966366 no 3070 0.0934797698783042 4373 56993 SGTC_1291 0993-0025 5.79 µM -1.32014766711275 0.0930560943978437 no 3071 0.0933928602849446 4362 4353356 SGTC_334 1502-1024 68.5 µM -1.32260977081131 0.0926344642794595 no 3072 0.0929825916217155 4395 3296216 SGTC_2996 9066192 71.4286 µM -1.32677929757947 0.0919236669833333 no 3073 0.0922908503280726 4391 6472854 SGTC_569 4130-2812 160 µM -1.32798065383004 0.0917196180837512 no 3074 0.0920922490634977 4240 743552 SGTC_1838 st055369 84.5 µM -1.33149144245175 0.0911252383193422 no 3075 0.0915136794625242 4369 676036 SGTC_15 0266-0086 27.098 µM -1.33227270483722 0.0909933593098125 no 3076 0.0913852965102813 4456 1712902 YIL048W NEO1 SGTC_213 1246-0773 967 nM -1.33343102110967 0.0907980933137083 no 3077 0.0911951989897767 4411 6251622 SGTC_3122 9126309 49.47 µM -1.33791092963409 0.0900458082831043 no 3078 0.0904627369243537 4480 17591206 SGTC_2702 st077768 96.8 µM -1.34073269256734 0.0895743490630156 no 3079 0.0900036280433069 4369 6484119 SGTC_2036 5160441 105 µM -1.34085931438248 0.089553236246389 no 3080 0.089983066976717 4359 134534 YIL048W NEO1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.34542687271314 0.088794117655729 no 3081 0.0892437109746455 4410 5357218 A potent inhibitor of glutathione S-transferases. SGTC_544 k015-0020 52.4 µM -1.34738352048229 0.0884703968503771 no 3082 0.0889283726572873 4419 3008304 SGTC_2347 9049783 174.81 µM -1.34912591200593 0.088182864897297 no 3083 0.088648263305867 4404 6467988 YPL169C MEX67 SGTC_1316 1272-0050 65.9 µM -1.34912929759055 0.0881823068821429 no 3084 0.088647719674872 4371 7340392 SGTC_303 1348-1668 34.2 µM -1.35269059797133 0.0875967866206731 no 3085 0.0880772476728496 4411 5380509 SGTC_2984 9022109 38.96 µM -1.35333516748509 0.0874911224658101 no 3086 0.0879742895610249 4426 6459207 SGTC_3181 9108277 49.47 µM -1.35456859861374 0.0872891915640403 no 3087 0.0877775218759804 4366 17097298 SGTC_3146 9095609 49.47 µM -1.35642082700281 0.0869866082864211 no 3088 0.0874826551859198 4447 17173999 SGTC_1304 1165-0502 251 µM -1.35787598581599 0.0867494410747618 no 3089 0.0872515192588904 4392 767425 SGTC_2665 lovastatin 100 µM -1.36333510960794 0.0858639988151688 no 3090 0.0863884608467336 4430 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_555 4296-0685 37 µM -1.36385924022164 0.0857793446651083 no 3091 0.0863059356414768 4392 2908540 YHR072W ERG7 SGTC_62 0180-0423 3.232 µM -1.36551302183626 0.0855126462245527 no 3092 0.0860459315729344 4385 30102 YGL099W LSG1 SGTC_804 1595-0054 20.9 µM -1.36567685050758 0.0854862601026386 no 3093 0.08602020671144 4384 761523 Stimulates phospholipase C. SGTC_92 0063-0024 660.874 µM -1.36734686510656 0.0852176366066241 no 3094 0.0857583043190814 4512 3594437 SGTC_738 1315-0003 72.4 µM -1.36956214141105 0.084862283794254 no 3095 0.0854118121568241 4433 6251474 SGTC_347 4534-1311 26.2 µM -1.37055260661123 0.0847037629935476 no 3096 0.0852572327954142 4419 2862016 SGTC_2932 9016711 44.54 µM -1.37091479587345 0.0846458512389759 no 3097 0.0852007592147049 4408 7117328 SGTC_1511 0906-3109 28.5 µM -1.37472937177237 0.0840377271643771 no 3098 0.0846076808516696 4410 2882180 SGTC_375 3970-0961 9.27 µM -1.37529207928181 0.0839482980217192 no 3099 0.0845204555711943 4380 2898222 SGTC_47 0149-0135 24.25 µM -1.37828897491269 0.0834732153186223 no 3100 0.0840570428950102 4435 5239155 SGTC_509 pifithrin 175 µM -1.38076086607643 0.0830828818893081 no 3101 0.0836762498709502 4500 4817 A p53 inhibitor. SGTC_1191 1487-1166 10.6 µM -1.38100311771451 0.0830447021968675 no 3102 0.0836390010257156 4451 3955771 SGTC_2506 ethyl hematommate 54.16 µM -1.38108293082396 0.0830321262663097 no 3103 0.0836267316139183 4461 3940691 An allergen. SGTC_1857 st056007 79.3 µM -1.38434071305335 0.0825200281617441 no 3104 0.0831270766320854 4392 619834 SGTC_1165 k072-0275 30.3 µM -1.39096099606659 0.081486701542869 no 3105 0.0821186273060859 4398 6153523 YGL055W OLE1 SGTC_343 4130-2827 29.8 µM -1.39245321194866 0.0812551425048208 no 3106 0.0818926002553989 4413 1118244 SGTC_1189 1431-2119 7.28 µM -1.3937271787485 0.0810578440475421 no 3107 0.0817000028244981 4415 3107275 SGTC_2894 9048625 32.47 µM -1.39563226628649 0.0807634792019719 no 3108 0.0814126303819383 4449 4092861 SGTC_400 oxethazaine 37.5 µM -1.39964528888626 0.0801460485552253 no 3109 0.0808097824180272 4465 4621 A local anesthetic. SGTC_574 1315-0397 40 µM -1.40154178906486 0.0798555036712834 no 3110 0.0805260601201216 4418 6794277 SGTC_1303 1160-0052 261 µM -1.4042036616141 0.0794490479210805 no 3111 0.0801291059113733 4384 3562476 SGTC_2005 4024620 188 µM -1.40551738921832 0.0792490256889273 no 3112 0.0799337410559638 4397 236743 SGTC_2727 riluzole 51.77 µM -1.414003645723 0.0779661219893035 no 3113 0.0786804160249091 4482 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_722 3534-0461 190 µM -1.4150645002494 0.0778068625326519 no 3114 0.0785247927454877 4466 658262 SGTC_2792 7535235 81.82 µM -1.41510728486761 0.0778004447290649 no 3115 0.0785185213049721 4421 1281891 SGTC_2041 5107442 45.335 µM -1.4172312611548 0.0774823475997877 no 3116 0.0782076623871009 4472 793005 SGTC_1754 st042065 16.137 µM -1.4235534778782 0.0765413464534384 no 3117 0.0772878855311724 4201 1126236 YIL048W NEO1 SGTC_1460 k062-0059 9.15 µM -1.4301529436711 0.0755683789942992 no 3118 0.0763365638239997 4349 1373085 SGTC_2568 diosmetin 100 µM -1.43189432993532 0.0753132223598303 no 3119 0.0760870326001068 4465 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3090 9117696 49.47 µM -1.4321457049859 0.075276443936732 no 3120 0.0760510632620939 4410 7923821 SGTC_723 4182-0001 115 µM -1.43387697652467 0.0750235151708486 no 3121 0.0758036865665548 4466 744821 YLR208W SEC13 SGTC_3320 9137005 35.139 µM -1.43421671666414 0.0749739572632881 no 3122 0.0757552140328348 4504 4908713 SGTC_1311 1190-0148 100 µM -1.43672916610368 0.0746082409515531 no 3123 0.0753974821083459 4497 1961333 SGTC_3228 9131799 49.47 µM -1.44105046311879 0.0739824127599491 no 3124 0.0747852134187209 4494 17015818 SGTC_2544 sphondin 68.51 µM -1.44148013289006 0.0739204060895356 no 3125 0.0747245430399347 4424 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_942 3253-1115 227 µM -1.44282890368813 0.0737260197334927 no 3126 0.074534337427443 4487 46497897 SGTC_1518 st038567 90.8 µM -1.44358830521804 0.0736167460017428 no 3127 0.074427408261227 4408 77966 SGTC_1973 st070275 50.2 µM -1.44520277097588 0.0733848447097846 no 3128 0.0742004691542346 4419 17118334 SGTC_1190 1486-1332 13 µM -1.44562024306587 0.0733249701820028 no 3129 0.074141872830828 4456 4150046 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.44655067425154 0.0731916606821877 no 3130 0.0740114048226708 4487 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1899 st063254 59.6 µM -1.44889208518321 0.0728570105956204 no 3131 0.0736838609169445 4427 3093813 SGTC_1087 pterostilbene 9.05 µM -1.45202650719963 0.0724108533297274 no 3132 0.0732471174873696 4475 5281727 Similar to reservatol, lowers cholesterol. SGTC_2742 clothiapine 36.27 µM -1.45239243325832 0.0723589037391017 no 3133 0.0731962595304861 4506 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1233 0325-0408 14.2 µM -1.45267231938908 0.0723191882963769 no 3134 0.0731573780070095 4500 12874 SGTC_1030 k029-0042 36.7 µM -1.45458829344922 0.0720477627285344 no 3135 0.0728916369079338 4450 6080581 SGTC_3245 9134821 49.47 µM -1.45661960000858 0.071760852274057 no 3136 0.0726107071336336 4488 17014901 SGTC_1266 0828-0227 32.9 µM -1.45663018320271 0.071759359756522 no 3137 0.0726092456520386 4443 3913820 SGTC_410 α-linolenic acid 100 µM -1.45732969429597 0.0716607624996956 no 3138 0.0725126969204383 4498 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1979 st071809 45.3 µM -1.46275520208491 0.0708995538978849 no 3139 0.0717671875859218 4516 4976333 SGTC_2865 9030313 51.95 µM -1.46637301610075 0.0703954301242985 no 3140 0.0712733467179051 4465 42562754 SGTC_3214 9129694 49.47 µM -1.46663014539093 0.0703597056493591 no 3141 0.0712383474529556 4491 17158655 SGTC_2731 amoxapine 43.43 µM -1.46806021628001 0.0701612718556459 no 3142 0.0710439334502133 4638 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2951 9072950 58.06 µM -1.4714245251085 0.0696961447904851 no 3143 0.0705881724650965 4401 16488155 SGTC_1365 1672-3266 55.4 µM -1.47711869228208 0.068914320408429 no 3144 0.0698219118878676 4500 6415873 SGTC_2030 5175110 200 µM -1.4776719312734 0.0688387209990429 no 3145 0.0697478053981668 4473 2831986 SGTC_1701 st028638 40.4 µM -1.47999542338279 0.0685219167156965 no 3146 0.0694372340177083 4495 3490878 SGTC_1213 1315-0166 115 µM -1.48212564383592 0.0682324540309061 no 3147 0.0691534333002325 4481 768401 SGTC_993 3909-8757 62.7 µM -1.48344994226116 0.068052979465231 no 3148 0.0689774533899179 4438 4288324 YLR208W SEC13 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.4914766958911 0.0669729486976983 no 3149 0.0679181925700616 4483 688751 SGTC_783 0848-0141 92.7 µM -1.49544806993505 0.0664435109923703 no 3150 0.0673987715587877 4423 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_486 niguldipine 82 µM -1.49942684845939 0.0659163414126026 no 3151 0.0668814663935885 4579 1236 A calcium channel blocker. SGTC_2418 pentamidine 31.67 µM -1.50091747547473 0.0657196770209693 no 3152 0.0666884537976157 4441 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1403 3909-7815 62.9 µM -1.50247429836127 0.0655147650656533 no 3153 0.0664873303800254 4490 6615483 SGTC_2183 6420625 130.508 µM -1.50253154354621 0.0655072398017566 no 3154 0.0664799439282104 4529 2897619 SGTC_1990 st072050 59.8 µM -1.50479976845258 0.0652096055537721 no 3155 0.0661877816604003 4484 17233948 SGTC_198 3454-2873 16.191 µM -1.50736891879206 0.0648737526544471 no 3156 0.0658580605073251 4498 710957 SGTC_2540 epiandrosterone 100 µM -1.50865219766592 0.0647064993546178 no 3157 0.0656938437355574 4528 441302 A steroid. SGTC_1602 st001878 87.6 µM -1.5092505599264 0.0646286277015939 no 3158 0.065617381978251 4484 595405 YLR310C CDC25 SGTC_2267 7931562 200 µM -1.51071139473573 0.0644388185167608 no 3159 0.0654309989881677 4449 934880 SGTC_3135 9127742 49.47 µM -1.51594376751734 0.0637625181743822 no 3160 0.0647667859786251 4557 3643468 SGTC_686 1319-0111 510 µM -1.51626919582288 0.0637206386368081 no 3161 0.0647256487211597 4513 4562600 SGTC_2097 5376186 200 µM -1.51889200089378 0.063383889295912 no 3162 0.0643948414095194 4476 742755 SGTC_2270 7924575 90.91 µM -1.52209383144666 0.0629746769153838 no 3163 0.0639927857055437 4480 1262135 SGTC_290 2043-6722 48.1 µM -1.53065970886983 0.0618900242161579 no 3164 0.0629267582516272 4529 773758 YLR208W SEC13 SGTC_233 rapamycin 362 pM -1.5347800507821 0.0613735070890995 no 3165 0.0624189323205359 4508 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1722 st034304 3.6505 µM -1.53617270845035 0.0611996900341574 no 3166 0.0622480138072424 4460 4036148 YLR033W RSC58 SGTC_2343 7990716 14.84 µM -1.54113556714808 0.0605834040536961 no 3167 0.0616418975590945 4519 6456862 SGTC_2194 5927483 104.545 µM -1.54357075679185 0.0602827839861281 no 3168 0.0613461769606672 4551 760979 SGTC_2197 6588183 93.1375 µM -1.54453479517619 0.0601640981654893 no 3169 0.0612294143220376 4534 884136 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.54713816109672 0.0598445035070964 no 3170 0.0609149668246611 4498 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_130 0136-0219 337.655 µM -1.55441331612137 0.0589584387998912 no 3171 0.0600429294617444 4415 234244 SGTC_3232 9132874 49.47 µM -1.55526149928991 0.0588558092989817 no 3172 0.0599419013875851 4499 3784940 SGTC_2900 5328528 85.29 µM -1.56576684779343 0.0575962599017348 no 3173 0.0587016050508853 4521 795359 SGTC_2677 mitomycin C 100 µM -1.56603111576579 0.0575648507461494 no 3174 0.058670666429217 4596 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_333 3486-0131 40.1 µM -1.57586702411355 0.056405372763169 no 3175 0.0575282260020044 4537 6744690 SGTC_637 1181-0519 7.26 µM -1.57625368542992 0.0563601711115718 no 3176 0.0574836753177315 4538 6252091 YGR060W ERG25 SGTC_3187 9109394 49.47 µM -1.58244145202058 0.0556406839454233 no 3177 0.0567744140427051 4543 17098090 SGTC_1287 0971-0001 34.6 µM -1.58484045314634 0.0553636961268495 no 3178 0.0565012943245375 4523 4665869 SGTC_2273 7815444 169.05 µM -1.58508227220466 0.0553358363004819 no 3179 0.056473821427306 4473 2824616 SGTC_764 1951-2361 146 µM -1.58693286303761 0.0551229972548443 no 3180 0.0562639254803968 4538 5438930 SGTC_1265 0819-1001 68.8 µM -1.58703201986114 0.0551116113696746 no 3181 0.0562526963929452 4478 3106768 SGTC_140 0062-0056 502.533 µM -1.58763965663786 0.0550418788069756 no 3182 0.0561839227032067 4447 3758964 SGTC_45 0kpi-0036 14.9 µM -1.59838112214865 0.0538206580449505 no 3183 0.0549790916624056 4519 2795021 SGTC_2918 7977171 22.06 µM -1.59937657631445 0.0537085776780358 no 3184 0.054868476870241 4529 2236483 SGTC_979 1426-2828 121 µM -1.60099958776214 0.053526235760532 no 3185 0.0546885052253609 4607 747872 SGTC_3175 9106517 49.47 µM -1.60288331580018 0.0533152182457044 no 3186 0.054480208926014 4569 41468073 SGTC_2437 5741531 144.16 µM -1.6029004157892 0.053313305708367 no 3187 0.0544783209447927 4556 2262990 SGTC_2450 5739737 12.93 µM -1.60716035180088 0.0528385475754729 no 3188 0.0540095984909093 4564 2262825 SGTC_3104 9120930 49.47 µM -1.60767843256802 0.0527810383606306 no 3189 0.0539528122485424 4578 17014836 SGTC_1486 3970-0793 4.53 µM -1.61769905074391 0.0516784455955984 no 3190 0.0528637353412996 4587 2844330 SGTC_1058 3448-5425 97.3 µM -1.62200916597752 0.0512098604750572 no 3191 0.0524006927791843 4494 7279705 SGTC_1035 k081-0041 55.2 µM -1.62353772541877 0.0510444935995616 no 3192 0.0522372527993747 4568 731709 SGTC_833 3852-0053 558 µM -1.6338809331647 0.0499366565598278 no 3193 0.0511419270117758 4606 3123681 SGTC_1134 3477-0009 42.5 µM -1.63583944567824 0.0497290600561467 no 3194 0.0509365970289957 4576 3973534 SGTC_3213 9129884 49.47 µM -1.63828192580675 0.0494711298418734 no 3195 0.0506814481310782 4532 17190742 SGTC_2964 9083345 53.42 µM -1.63896306945624 0.0493993906094954 no 3196 0.0506104756027327 4527 17741579 SGTC_1021 4476-0760 85.3 µM -1.64574910816543 0.0486891998143349 no 3197 0.0499077119677387 4582 746768 SGTC_2517 totarol 10 µM -1.64875440377391 0.0483773002295639 no 3198 0.0495989797931444 4572 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_623 k072-0108 16.9 µM -1.65239207026834 0.0480019111531831 no 3199 0.0492273255031285 4542 5382803 SGTC_2837 9008476 45.46 µM -1.65661263924645 0.0475692950617833 no 3200 0.0487989076711811 4528 2992805 SGTC_1787 fluconazole 80 µM -1.65723287235602 0.0475059840515599 no 3201 0.0487362014680676 4222 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_32 0928-0142 34.1 µM -1.65728085399991 0.047501089084299 no 3202 0.0487313531598138 4581 2244242 SGTC_2003 4023581 200 µM -1.65885855738277 0.0473403606882042 no 3203 0.0485721486521975 4578 16641307 SGTC_1238 0333-0287 48.8 µM -1.65977864512503 0.0472468282074447 no 3204 0.0484794956407276 4573 7226 SGTC_1791 st048313 56.1 µM -1.67027219506393 0.0461905399767059 no 3205 0.0474327608975724 4588 1204976 SGTC_2294 7971431 200 µM -1.67060472673606 0.0461573796751255 no 3206 0.0473998891267645 4563 5741572 SGTC_1179 1021-1431 9.29 µM -1.67368559596132 0.0458510614932986 no 3207 0.0470962030550669 4592 2840958 SGTC_543 3844-1095 191 µM -1.67408119073375 0.0458118477496648 no 3208 0.0470573219245344 4586 4230703 SGTC_1759 st043059 70 µM -1.67761358471657 0.0454628891455122 no 3209 0.0467112795367068 4593 669426 SGTC_286 k060-0067 22.9 µM -1.67967882579831 0.0452598600922433 no 3210 0.0465099108492439 4617 5985051 SGTC_1447 4239-0816 81.9 µM -1.68222968910449 0.0450100982128657 no 3211 0.0462621545778629 4602 1341554 SGTC_2383 9036125 200 µM -1.68361963338435 0.0448744726669945 no 3212 0.0461276009492308 4543 79580 SGTC_2090 5301565 104.445 µM -1.68440869500984 0.0447976255200525 no 3213 0.0460513557779952 4594 2056344 SGTC_2249 haloperidol 116.36 µM -1.68919907730992 0.0443333592420132 no 3214 0.0455906428858543 4515 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2385 9074692 200 µM -1.70040141642586 0.0432627993485747 no 3215 0.0445277227935509 4595 17046906 SGTC_154 3389-1638 511.116 µM -1.70399560015803 0.0429237758785335 no 3216 0.0441909546153039 4587 5238686 SGTC_221 trifluoperazine 10.304 µM -1.71242955841411 0.0421366639370582 no 3217 0.0434087678611113 4584 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1669 st015249 58.4 µM -1.7150158539986 0.0418976478217927 no 3218 0.0431711601349833 4692 722793 SGTC_2654 protoveratrine a 100 µM -1.7201110322648 0.0414299816316979 no 3219 0.0427061303677711 4607 5702278 A heart drug and vasodilator. SGTC_2526 patulin 37.61 µM -1.72437023598264 0.0410423003500758 no 3220 0.0423205135975233 4584 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_983 1491-0821 12.2 µM -1.72976188755936 0.0405557663688447 no 3221 0.0418364132041753 4609 46495113 SGTC_589 1227-0070 34.1 µM -1.73052153224882 0.0404875950871735 no 3222 0.0417685687832275 4643 2841384 SGTC_2507 purpurin 79.67 µM -1.73173104501928 0.0403792442027232 no 3223 0.0416607302157426 4581 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_169 k015-0017 16.025 µM -1.74458460422489 0.0392422792148403 no 3224 0.0405286013382718 4567 1840002 SGTC_2931 9014674 55.67 µM -1.74835046178644 0.0389141486511378 no 3225 0.0402016801450266 4558 2996810 SGTC_1364 1653-0028 37.6 µM -1.76323810294843 0.0376387540286974 no 3226 0.0389301699334735 4625 5718652 SGTC_3037 9091026 49.47 µM -1.77607834242048 0.0365663552778697 no 3227 0.0378600026814255 4493 25236398 YIL048W NEO1 SGTC_2945 9067681 61.76 µM -1.78311962508883 0.0359889717116351 no 3228 0.0372834162218977 4649 16456930 SGTC_194 1486-1323 56.904 µM -1.78519791686481 0.035819986720734 no 3229 0.0371146098763755 4692 5178754 SGTC_1721 st082152 9.2685 µM -1.78874860815642 0.0355327860931667 no 3230 0.0368276554264745 4573 5296051 SGTC_2726 cimetidine 79.27 µM -1.78886220100127 0.0355236292966125 no 3231 0.0368185052826371 4653 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2655 perillic acid 100 µM -1.79315200383701 0.0351792389688273 no 3232 0.0364743110970946 4669 5702197 An apoptosis inducer. SGTC_2683 piperine 63.03 µM -1.79565946322279 0.0349792089062884 no 3233 0.03627434628677 4667 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2256 7954252 200 µM -1.79991037331906 0.0346422301343973 no 3234 0.0359373957243768 4637 2972920 SGTC_2992 9074591 71.4286 µM -1.8175990750152 0.0332685216041424 no 3235 0.0345627165606216 4586 17741321 SGTC_947 3447-0010 211 µM -1.81869364456987 0.0331850124317469 no 3236 0.0344790909388808 4581 748350 SGTC_2971 9092186 9.93 µM -1.82381150615684 0.0327968380601526 no 3237 0.0340902868863225 4592 25236400 SGTC_950 1165-0508 94.1 µM -1.82387877619604 0.0327917608629035 no 3238 0.0340852004834677 4619 6148369 SGTC_1971 st069429 63.5 µM -1.83562627280138 0.0319150058699368 no 3239 0.0332064743707306 4637 1246522 YGL099W LSG1 SGTC_2350 9023895 38.85 µM -1.83953282664284 0.0316277717699543 no 3240 0.0329184271086298 4596 2997209 SGTC_1683 st010134 710 nM -1.84125213684354 0.0315020361581437 no 3241 0.0327923091106476 4610 3818134 SGTC_2715 st079500 56.4 µM -1.84323480160586 0.0313575543285411 no 3242 0.0326473678708743 4646 28246688 SGTC_789 1309-1135 70.6 µM -1.84521986695955 0.0312134469310214 no 3243 0.0325027808210447 4621 3092424 SGTC_1629 st005085 44.9 µM -1.8717835035176 0.0293372019671402 no 3244 0.0306182807136998 4613 24207091 SGTC_2679 rapamycin 1 nM -1.88143533107129 0.028679095909489 no 3245 0.0299563622627931 4506 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1862 st057513 3.81 µM -1.88487139597799 0.0284477924093443 no 3246 0.0297236013975169 4656 5393163 SGTC_1745 st081495 74 µM -1.88512248048917 0.0284309513335325 no 3247 0.0297066517959808 4521 13842402 YBL026W LSM2 SGTC_1913 st060213 96.1 µM -1.88756680875496 0.0282674351371912 no 3248 0.0295420647359084 4630 688959 SGTC_954 1189-0853 2.85 µM -1.88935458900194 0.0281483357436297 no 3249 0.0294221657089259 4603 2828194 SGTC_1746 st038117 42 µM -1.88978850671129 0.0281194918495573 no 3250 0.0293931256541533 4659 2898218 SGTC_577 r071-0003 38.6 µM -1.89641211087659 0.0276822461736868 no 3251 0.0289527858385261 4631 4568517 YMR134W ERG29 SGTC_348 k064-0012 10.7 µM -1.90415991352893 0.0271779937400556 no 3252 0.0284446803467967 4639 5066323 SGTC_2195 6536160 144.242 µM -1.91320689731027 0.0265989084287968 no 3253 0.0278607854433785 4679 3834386 SGTC_1864 st057645 30.4 µM -1.91507084712628 0.0264808890987301 no 3254 0.0277417345456694 4696 688666 SGTC_3290 9121031 71.43 µM -1.92132221637406 0.0260882625869275 no 3255 0.0273455489961158 4669 17014854 SGTC_3247 9135149 49.47 µM -1.92336981286237 0.0259607235233175 no 3256 0.0272168113249195 4686 8934436 YOR116C RPO31 SGTC_1462 k081-0014 26.5 µM -1.92779508952932 0.0256868665625084 no 3257 0.0269403093766213 4098 3270634 SGTC_1080 nisoldipine 24.4 µM -1.92877563652711 0.0256265140961108 no 3258 0.0268793608347661 4696 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3276 9139060 49.47 µM -1.92877832044326 0.0256263490646797 no 3259 0.0268791941668333 4704 4870619 SGTC_3035 9091303 49.47 µM -1.93484804993549 0.0252553967324034 no 3260 0.0265044723654957 4698 25237002 SGTC_3129 9127257 49.47 µM -1.93690047185333 0.0251309850285972 no 3261 0.0263787553879863 4619 837894 SGTC_2976 9009005 19.48 µM -1.94158973523472 0.02484866234007 no 3262 0.0260933932600857 4629 2993148 SGTC_1234 0326-0494 15.5 µM -1.94198965702817 0.0248247081590333 no 3263 0.0260691762111921 4702 1547813 SGTC_2777 climbazole 1.536 µM -1.9468739146661 0.0245337144015427 no 3264 0.0257749263332679 4456 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_229 benomyl 22.8748 µM -1.94708404728364 0.0245212596467113 no 3265 0.0257623296097832 4695 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2939 9044578 71.43 µM -1.95490494141568 0.0240614681742215 no 3266 0.025297145609551 4611 2653634 SGTC_1670 st016595 4.04 µM -1.96448808592475 0.0235079703075863 no 3267 0.0247367582955883 4697 597879 SGTC_3351 9150312 21.596 µM -1.97705373151974 0.0227984759293452 no 3268 0.0240177784819962 4609 4904905 SGTC_2026 5148700 152 µM -1.97717741745318 0.0227915829315422 no 3269 0.0240107896459248 4675 79838 SGTC_1814 st052110 31.539 µM -1.98421839047569 0.0224020759053108 no 3270 0.0236157496305132 4631 674163 SGTC_2537 larixol 68.93 µM -1.99299946995225 0.0219241873356698 no 3271 0.0231307525619076 4656 6708759 SGTC_2823 7987624 58.44 µM -1.99925493628817 0.0215890238335176 no 3272 0.0227903886407231 4617 2239440 SGTC_338 4055-0136 114 µM -1.99976794451578 0.0215617303568351 no 3273 0.0227626637557941 4673 2900563 SGTC_2923 7992654 58.14 µM -2.0140806948402 0.0208119253613387 no 3274 0.0220005310099714 4645 2985126 SGTC_2970 9090938 41.86 µM -2.01445231560995 0.0207927549913857 no 3275 0.0219810332301169 4686 17217104 SGTC_3298 9116858 71.43 µM -2.01530388126717 0.0207488826381174 no 3276 0.0219364092543287 4712 2506942 SGTC_2314 7727897 200 µM -2.02475854339393 0.020267026006356 no 3277 0.0214460819497447 4653 900724 SGTC_1356 1502-0781 85.8 µM -2.03157474624403 0.0199255527720084 no 3278 0.0210983627164177 4705 567702 SGTC_1197 1601-0112 267 µM -2.06415654887728 0.0183599717559725 no 3279 0.0195014378891894 4679 7350313 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -2.06612848452699 0.0182686790616815 no 3280 0.019408174643696 4746 688801 SGTC_1349 flufenamic acid 69 µM -2.07461331411056 0.0178802654519587 no 3281 0.0190111935773797 4650 3371 A non-steroidal anti-inflammatory. SGTC_1803 st050068 52.4 µM -2.08011146005545 0.0176323534184513 no 3282 0.018757655349336 4697 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1631 benzylvanillin 81.9 µM -2.08392431996713 0.0174621588714115 no 3283 0.0185835258869616 4703 75506 SGTC_1841 st054148 70 µM -2.08905470433454 0.0172353689425223 no 3284 0.0183513995537575 4719 675442 SGTC_2803 7707263 71.43 µM -2.0914630978996 0.0171297762018949 no 3285 0.0182432855373289 4669 2199229 SGTC_2725 haloperidol 53.21 µM -2.10567412180278 0.0165179036498449 no 3286 0.0176163346058312 4689 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3217 9129673 49.47 µM -2.10716328547457 0.0164548823817105 no 3287 0.0175517140957375 4672 17248312 SGTC_1866 st057638 64 µM -2.12796490259315 0.0155958560748978 no 3288 0.0166699968309874 4728 688802 SGTC_1250 0485-0349 40.2 µM -2.12884591432321 0.015560339414239 no 3289 0.0166335053903534 4681 6842794 YDL195W SEC31 SGTC_2692 st077426 47.7 µM -2.13175452866904 0.0154435754618582 no 3290 0.0165135157661468 4691 25238571 SGTC_2189 6047310 154.431 µM -2.1330427301377 0.0153921024897652 no 3291 0.016460610543069 4737 711535 SGTC_977 1348-1378 135 µM -2.14000436010579 0.0151164767322422 no 3292 0.0161772071917781 4698 X977 SGTC_1837 st055472 66.5 µM -2.14037631443485 0.0151018703822156 no 3293 0.0161621835478356 4732 676091 SGTC_1050 3232-1156 69.3 µM -2.14556605306155 0.0148993351764223 no 3294 0.015953808126111 4699 700529 SGTC_2333 9017922 200 µM -2.15074064950719 0.0146997205099643 no 3295 0.0157483379853887 4685 3163164 SGTC_2927 9011802 47.9 µM -2.1542177739163 0.0145668834539245 no 3296 0.0156115488160445 4671 43912568 SGTC_2250 alverine citrate 130 µM -2.16547472272038 0.0141438950977832 no 3297 0.0151756745602936 4589 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2222 6885208 172.143 µM -2.17941213376868 0.0136348854344084 no 3298 0.0146505327752774 4751 609514 SGTC_3116 9124943 49.47 µM -2.20348783893192 0.0127928087042365 no 3299 0.0137801915891109 4721 41905195 YPL160W CDC60 SGTC_1064 honokiol 6.76 µM -2.22426262943212 0.0121027240131611 no 3300 0.0130653897334504 4722 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3210 9128157 49.47 µM -2.22953047958092 0.011932955640128 no 3301 0.0128893148235075 4662 17590849 SGTC_1800 st050079 29.0735 µM -2.25207657173515 0.0112294884475803 no 3302 0.0121587167732513 4602 3645560 SGTC_3312 9133330 71.43 µM -2.25338766557839 0.0111897134740051 no 3303 0.0121173582790647 4734 17617324 SGTC_1887 st057648 70.8 µM -2.26258811734074 0.0109140271390285 no 3304 0.0118305456535922 4737 688672 SGTC_1932 st074806 40.9 µM -2.26741544019268 0.0107717575019632 no 3305 0.011682429577218 4739 17251235 SGTC_1860 st056228 74.6 µM -2.26887881595073 0.0107289494013225 no 3306 0.0116378481497361 4733 688679 SGTC_75 0159-0059 199.013 µM -2.26961125265254 0.010707579125358 no 3307 0.0116155901391548 4719 5377270 SGTC_2802 7925815 54.55 µM -2.27418337062917 0.0105750146394769 no 3308 0.0114774818304602 4703 1262923 SGTC_2067 5224629 34.075 µM -2.27657914606814 0.010506123862321 no 3309 0.011405684681876 4717 2835000 SGTC_1476 4112-3294 3.34 µM -2.28830049438104 0.0101746831806063 no 3310 0.0110600138745988 4730 704369 SGTC_679 0422-0091 41.4 µM -2.30163684653268 0.00980870188569709 no 3311 0.0106778301994259 4747 627384 YHR062C RPP1 SGTC_1358 1509-0022 2.48 µM -2.30654320435006 0.00967698215036095 no 3312 0.0105401494599669 4750 3258434 SGTC_1933 st074711 15.9 µM -2.30686864294871 0.00966830010314124 no 3313 0.0105310720474799 4735 17250958 SGTC_3252 9135871 49.47 µM -2.32540700064921 0.00918483935470886 no 3314 0.0100251037512356 4748 17682838 SGTC_2753 fluvastatin 17.09 µM -2.33981814950668 0.00882376335142648 no 3315 0.00964656570133974 4716 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1366 1683-0113 21.9 µM -2.35808680062782 0.0083839602384526 no 3316 0.00918469857816911 4753 708623 SGTC_1840 st055363 71 µM -2.36883236356148 0.00813435959865487 no 3317 0.00892216968898449 4745 676033 SGTC_407 eburnamonine 100 µM -2.43628233921935 0.00671163793935542 no 3318 0.00741954851877451 4681 3195 SGTC_1774 st048371 48.465 µM -2.45079061205776 0.00643605579539689 no 3319 0.00712714226513706 4752 4242727 SGTC_2856 9022925 19.48 µM -2.45968178784984 0.00627216082923925 no 3320 0.00695301260238341 4736 4944862 SGTC_3333 9141820 12.094 µM -2.49661473601798 0.00563024304815138 no 3321 0.00626925493906675 4732 1939433 SGTC_1934 st074720 32.6 µM -2.50186904971997 0.00554382678698189 no 3322 0.00617698050112052 4716 17250992 SGTC_3294 9122953 26.2835 µM -2.50536340928211 0.00548701035055987 no 3323 0.00611628179216349 4741 16459826 SGTC_1927 st060202 13.8 µM -2.50899894638822 0.00542844820613215 no 3324 0.0060536922762138 4733 688887 SGTC_1818 st052136 56.3 µM -2.53896211268455 0.00496656891053937 no 3325 0.0055590931408271 4559 674169 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.55696779739077 0.00470616394155496 no 3326 0.00527944959182302 4765 75037 A free radical scavenger. SGTC_2783 7738165 71.43 µM -2.57118607852026 0.00450921364140094 no 3327 0.00506754270423069 4741 17201110 SGTC_2442 5158906 48.48 µM -2.61480747759105 0.00395009024605964 no 3328 0.00446388812753942 4761 1893835 SGTC_820 1582-0060 59.9 µM -2.64891615905651 0.0035570532658451 no 3329 0.00403751807665574 4777 3848840 SGTC_2529 gangaleoidin 93.61 µM -2.65341305510684 0.00350794422339671 no 3330 0.00398411478792912 4765 4565183 SGTC_2561 acetosyringone 100 µM -2.67141598960956 0.00331738184615883 no 3331 0.00377659884046204 4763 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_302 1094-0063 18.9 µM -2.70254766803654 0.00300970616287331 no 3332 0.00344051585170236 4782 5440289 SGTC_559 1550-0661 158 µM -2.71543317441347 0.00289006382793915 no 3333 0.00330945664394921 4786 5830875 SGTC_72 0744-0168 198.391 µM -2.78503298905895 0.00231489957896313 no 3334 0.00267611387236255 4739 677577 SGTC_2593 nobiletin 86.24 µM -2.78598918682964 0.00230777648339931 no 3335 0.00266823259117017 4760 72344 An anti-infammatory. SGTC_2721 ifenprodil 61.44 µM -2.86203396596102 0.00180095723440142 no 3336 0.0021046589705394 4775 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1111 tnp00062 510.699 nM -2.87575114806406 0.00172113536317035 no 3337 0.0020153367403095 4761 676306 SGTC_1884 5633444 25 µM -2.93237667125098 0.00142458406826701 no 3338 0.00168189246894307 4758 5724239 SGTC_2854 9024559 71.43 µM -2.93636444433828 0.00140557060246966 no 3339 0.0016604196166149 4774 3163529 SGTC_1263 0774-1208 64.8 µM -2.94537499109334 0.00136345934267662 no 3340 0.00161281731919924 4775 906585 SGTC_2853 9015042 58.44 µM -2.97407240479641 0.00123690575623773 no 3341 0.00146937861193401 4762 6457456 SGTC_1352 1496-0991 99 µM -3.08566709763404 0.000840354973549691 yes 3342 0.00101548035299245 4802 3000039 SGTC_2445 5742597 35.57 µM -3.22477098357363 0.000510147734712958 yes 3343 0.000630367389870146 4800 1774255 SGTC_1883 5-benzylidenerhodanine 20 µM -3.24183003691815 0.000479222688686402 yes 3344 0.000593824145579399 4801 1273210 SGTC_1680 diphenhydramine 100 µM -3.27280157372954 0.000427472108106705 yes 3345 0.000532436028544104 4780 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3072 9116419 49.47 µM -3.27777082241753 0.000419668400574441 yes 3346 0.000523151535685179 4790 17170162 SGTC_511 blebbistatin 171 µM -3.38676844272177 0.00027842294577895 yes 3347 0.000353605254521459 4807 3476986 A myosin inhibitor. SGTC_68 0986-0284 82.829 µM -3.62824982783021 0.000107523131835429 yes 3348 0.000142674535292964 4774 423278 YIL048W NEO1 SGTC_2688 kanamycin b 96.69 µM -3.68505614256807 8.52320119312792e-05 yes 3349 0.00011432611638233 4785 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1936 st074407 74.3 µM -3.73722371074801 6.86592812131998e-05 yes 3350 9.30316833621825e-05 4795 809813 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -3.82052287662249 4.8337675659423e-05 yes 3351 6.65845259491833e-05 4786 6728940 SGTC_2276 7947513 42.08 µM -3.85026743271964 4.25720279793986e-05 yes 3352 5.8994460468637e-05 4799 2105100 SGTC_1108 betulinic acid 729.144 nM -4.12395867333301 1.26853415275732e-05 yes 3353 1.86207871343507e-05 4781 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2696 st077691 74.316 µM -4.52010924953499 1.92141040136402e-06 yes 3354 3.09038636048989e-06 4803 757133 SGTC_77 0828-0286 12.516 µM -5.03486777133669 1.3013053520304e-07 yes 3355 2.39089396807895e-07 4801 745345 SGTC_1112 tnp00069 1.16933 µM -5.5517774040186 6.62403139249342e-09 yes 3356 1.41389765830055e-08 4802 145826