SGTCid condition conc unit RHO1|YPR165W.score RHO1|YPR165W.strain.pval RHO1|YPR165W.strain.significant RHO1|YPR165W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3285 9112818 20.8695 µM 34.5447274037961 2.44401762458727e-145 yes 1 8.55203239740818e-262 1 17017947 YPR165W RHO1
SGTC_2289 7946404 165.07 µM 32.643797528444 5.27153006244864e-130 yes 2 4.9068077992912e-234 1 1246120 YPR165W RHO1
SGTC_863 0466-0191 129 µM 29.4473197846721 3.57443493967041e-106 yes 3 6.81237068075271e-191 1 765160 YPR165W RHO1
SGTC_3311 9131146 2.8755 µM 25.907649861529 1.21924601559028e-82 yes 4 2.73046499772663e-148 1 4900406 YPR165W RHO1
SGTC_586 0957-0265 8.15 µM 25.3768945221868 2.26964570592705e-79 yes 5 2.26907199899225e-142 2 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3350 9150499 3.57 µM 24.9239261715818 1.23947922207701e-76 yes 6 2.04774608338037e-137 1 4910996 YPR165W RHO1
SGTC_663 1486-0733 13.9 µM 24.6214559935513 7.82895350836105e-75 yes 7 3.72160572032165e-134 1 722445 YPR165W RHO1
SGTC_964 1287-0107 19.4 µM 24.5433322584409 2.26557377249076e-74 yes 8 2.54773869884297e-133 1 51516812 YPR165W RHO1
SGTC_3331 9141060 1.957 µM 24.5060824456182 3.75575443828534e-74 yes 9 6.36147837564212e-133 1 4906567 YPR165W RHO1
SGTC_3322 9139058 2.11 µM 23.1413676667819 2.44424415278134e-66 yes 10 8.879615608798e-119 1 4908926 YPR165W RHO1
SGTC_2028 5153890 36.43 µM 21.6574326977818 2.38934841400894e-58 yes 11 2.58634621758255e-104 1 2830968 YPR165W RHO1
SGTC_951 1171-0579 82.7 µM 21.5872393252684 5.53578191174906e-58 yes 12 1.18369197228116e-103 1 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2619 obliquin 87.91 µM 21.4639511610492 2.40567978728957e-57 yes 13 1.69148601739566e-102 2 6708593 A bioactive alkalod. YER133W GLC7
SGTC_360 0957-0399 1.01 µM 20.9517862218286 9.83878352878975e-55 yes 14 9.03619828083513e-98 1 6752301 YPR165W RHO1
SGTC_883 0850-0245 24.6 µM 18.3792555735003 1.45351604135112e-42 yes 15 9.62967465373676e-76 1 6823229 YPR165W RHO1
SGTC_2272 7805186 180 µM 17.7974745559153 4.95777696234175e-40 yes 16 3.69641596435598e-71 1 2956062 YPR165W RHO1
SGTC_905 2-aminofluorene 215 µM 17.551328720907 5.52818134740977e-39 yes 17 2.90523124186965e-69 1 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3266 9136860 49.47 µM 17.4466887969512 1.52552452521577e-38 yes 18 1.8238765131297e-68 1 4871271 YPR165W RHO1
SGTC_2124 5246320 200 µM 16.4784566994549 1.37559213113729e-34 yes 19 2.62028022670997e-61 1 579342
SGTC_450 aminopyrene 156 nM 16.1530430431041 2.61530017914163e-33 yes 20 5.40474454234576e-59 1 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2912 7964298 10.93 µM 16.1403450684518 2.93034374152008e-33 yes 21 6.63984082938052e-59 3 2975850
SGTC_2149 5554786 194.827 µM 15.8422912902212 4.12426417438003e-32 yes 22 7.94614255318686e-57 1 745063 YPR165W RHO1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 15.2633037999207 6.10509816790136e-30 yes 23 6.71370619097837e-53 1 6708739 YPR165W RHO1
SGTC_1874 staurosporine 7.6 µM 15.0870138888555 2.69555801268284e-29 yes 24 9.85828095371628e-52 1 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1053 3366-3204 134 µM 14.3252549339113 1.35647576115028e-26 yes 25 7.60843359846333e-47 1 3632071 YPR165W RHO1
SGTC_138 0850-0259 40.9225 µM 14.1359417938942 6.05920326080816e-26 yes 26 1.14031161112833e-45 6 6813004
SGTC_2399 5884133 200 µM 12.9093508075422 6.12704989403554e-22 yes 27 1.99323880375893e-38 1 722445
SGTC_58 0957-0393 9 µM 12.769439192997 1.6646846417097e-21 yes 28 1.21449097416628e-37 4 6997992
SGTC_3356 9151811 4.48 µM 12.4611565942807 1.45002033949593e-20 yes 29 6.07971133837817e-36 1 1859254 YPR165W RHO1
SGTC_304 1310-0298 97 µM 11.1213196284004 9.65717935041417e-17 yes 30 4.93998449050048e-29 1 1550234
SGTC_483 fpl-64176 144 µM 10.7572602803136 8.91743159779734e-16 yes 31 2.7387216207044e-27 1 3423
SGTC_2180 6301957 200 µM 10.7368641014443 1.00785227467107e-15 yes 32 3.41629477899326e-27 1 845462
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 10.6918218699601 1.31958822896058e-15 yes 33 5.55827699149416e-27 1 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_514 4466-0038 2.65 nM 10.6916269705423 1.32112476249754e-15 yes 34 5.56997129633803e-27 1 5722064
SGTC_2109 5483026 200 µM 10.3527551509346 9.68484105006872e-15 yes 35 2.03306517083459e-25 8 759335
SGTC_2009 4012297 12.05 µM 10.1447860866088 3.18858331767671e-14 yes 36 1.74771685436586e-24 1 45595307
SGTC_642 0335-0876 158 µM 9.96404105509689 8.81168361391241e-14 yes 37 1.09488393722497e-23 1 6812350
SGTC_268 camptothecin 39.6153 µM 9.6550310616784 4.80766371478913e-13 yes 38 2.34008710738943e-22 7 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1672 st016598 6.51 µM 9.47501313491688 1.26131898542383e-12 yes 39 1.3336357412162e-21 2 4665860 YNL267W PIK1
SGTC_1162 k048-0130 20.1 µM 9.37500369160117 2.13913984710965e-12 yes 40 3.45866745233757e-21 1 6797406
SGTC_354 2783-3500 4.88 µM 8.96744624259484 1.74091718524608e-11 yes 41 1.51734264748439e-19 4 6740761
SGTC_1374 2889-5571 141 µM 8.93496016477662 2.04962155251474e-11 yes 42 2.0366246829017e-19 15 2853281
SGTC_1510 1123-0200 71.5 µM 8.60380644199635 1.04761658323415e-10 yes 43 3.85574929298882e-18 3 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2007 4011539 71.82 µM 8.55939501172269 1.2979675631428e-10 yes 44 5.67306687225638e-18 1 45595301
SGTC_2533 agelasine 13.65 µM 8.54316666618177 1.40331050712236e-10 yes 45 6.52964188318699e-18 4 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2620 irigenin 100 µM 8.31170013566308 4.20531568550128e-10 yes 46 4.71702866209009e-17 2 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2367 9070478 135.38 µM 8.13955737186509 9.33534988381404e-10 yes 47 1.98362788213372e-16 2 572802
SGTC_3351 9150312 21.596 µM 7.91214178955476 2.61226177135562e-09 yes 48 1.26499002065109e-15 3 4904905
SGTC_3344 9148862 3.898 µM 7.86256940258114 3.25702997001902e-09 yes 49 1.88166465707613e-15 1 4905352
SGTC_1880 MG-132 525 µM 7.77181130251172 4.86108515487414e-09 yes 50 3.86858265426728e-15 4 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2210 7115885 190.385 µM 7.67782708572248 7.32480118415313e-09 yes 51 8.09048483931911e-15 1 2927039
SGTC_2022 5136654 200 µM 7.65765197907648 7.99374613326487e-09 yes 52 9.46815981805691e-15 1 1713771
SGTC_3122 9126309 49.47 µM 7.65277057914471 8.16430482241962e-09 yes 53 9.83473265446324e-15 1 17591206
SGTC_457 grayanotoxin iii 135 µM 7.46666706182488 1.80854637171395e-08 yes 54 4.11257643157557e-14 4 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_721 1187-1332 279 µM 7.37567279741613 2.65015965614375e-08 yes 55 8.17585805599999e-14 1 25730
SGTC_91 0417-1751 58.384 µM 7.24513537733793 4.54939959469421e-08 yes 56 2.16003739467372e-13 3 6795624
SGTC_2756 carbadox 75.1 µM 7.12764309504794 7.34152827337082e-08 yes 57 5.105105306964e-13 7 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2584 androsterone 48.74 µM 7.10443115699427 8.06242467570335e-08 yes 58 6.04095631634009e-13 7 2754130 A steroid.
SGTC_643 k048-0106 28.4 µM 7.07873220316434 8.94040154286363e-08 yes 59 7.27396009738259e-13 6 6763920
SGTC_255 tunicamycin 200.472 nM 7.05020734317849 1.00231596431031e-07 yes 60 8.9325690230768e-13 8 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2140 5586273 200 µM 6.87151271484825 2.03102331240839e-07 yes 61 3.1762314163354e-12 2 854421
SGTC_1959 st077091 55.8 µM 6.80671781640566 2.61272724150768e-07 yes 62 4.99252541870881e-12 10 821356 YKL052C ASK1
SGTC_2417 cerulenin 830 nM 6.68021781304894 4.24449297290773e-07 yes 63 1.19293686749996e-11 4 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2648 atorvastatin 78.68 µM 6.59715453511294 5.81001960154432e-07 yes 64 2.09561918524168e-11 4 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_673 1082-0474 110 µM 6.53043693482924 7.45655778127384e-07 yes 65 3.27890483249512e-11 25 3098046
SGTC_598 3937-0236 20.2 µM 6.50118751261728 8.31225962546576e-07 yes 66 3.98442130403961e-11 1 1379313
SGTC_430 0958-0115 16.4 µM 6.47508521843184 9.15494926686359e-07 yes 67 4.73792227005819e-11 2 6833180
SGTC_3321 9137793 26.8275 µM 6.44501890121648 1.02274155291399e-06 yes 68 5.77930054371869e-11 7 4904192
SGTC_574 1315-0397 40 µM 6.38662919085129 1.26648152346186e-06 yes 69 8.47910868214034e-11 2 6794277
SGTC_837 0091-0265 12.5 µM 6.36954116057743 1.34777555559707e-06 yes 70 9.47972678444224e-11 1 759367
SGTC_1239 0337-0584 35.4 µM 6.33696585413579 1.51682953917033e-06 yes 71 1.17166949109067e-10 13 914301 YML130C ERO1
SGTC_1493 4348-0038 111 µM 6.28665908853025 1.81847711881943e-06 yes 72 1.62185299350262e-10 13 800424
SGTC_3304 9125678 46.087 µM 6.07849356425463 3.79698210062312e-06 yes 73 6.06584253908719e-10 20 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1773 st048542 73.5835 µM 6.04572521689093 4.25458750352218e-06 yes 74 7.43697065405776e-10 10 3237138
SGTC_871 0574-0004 149 µM 5.98614053209807 5.22497571173215e-06 yes 75 1.07439363658655e-09 16 9551173
SGTC_582 0987-0078 156 µM 5.93357590394483 6.25344347025782e-06 yes 76 1.4820343540153e-09 4 1625765
SGTC_1115 galangin 695.678 nM 5.86957134198153 7.76744119384693e-06 yes 77 2.18461657463067e-09 2 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2304 7443016 91.4 µM 5.78596542516291 1.02766689176181e-05 yes 78 3.60485216817516e-09 2 939854
SGTC_3279 9140807 49.47 µM 5.77503710647888 1.06567505027274e-05 yes 79 3.84680640849216e-09 2 45595718
SGTC_2890 9046729 58.44 µM 5.77256834074376 1.07444471104695e-05 yes 80 3.90361314353746e-09 10 903329
SGTC_1124 fisetin 1.16336 µM 5.75662825542022 1.13274332440701e-05 yes 81 4.29052958497207e-09 4 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2475 5812728 15.03 µM 5.74034076924971 1.19541508892039e-05 yes 82 4.72431131474531e-09 8 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2248 tofa 1.1 µM 5.72484897740564 1.25807588095071e-05 yes 83 5.17628964399132e-09 17 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_486 niguldipine 82 µM 5.70832524658902 1.32834885946847e-05 yes 84 5.70466194166669e-09 1 1236 A calcium channel blocker.
SGTC_2057 5236571 38.335 µM 5.64708727148319 1.62273627255633e-05 yes 85 8.15945008491842e-09 8 54684039 YBR257W POP4
SGTC_2536 dehydroabietamide 32.04 µM 5.55837386340325 2.16103635467808e-05 yes 86 1.36149817420127e-08 2 3983547
SGTC_1707 st032323 6.317 µM 5.54916339790838 2.22574616606563e-05 yes 87 1.43519907993701e-08 19 3132057 YMR211W DML1
SGTC_2700 st077718 96.8 µM 5.48707188304412 2.71237446600881e-05 yes 88 2.04325435849418e-08 2 904970
SGTC_2582 agaric acid 100 µM 5.48544504283787 2.72638841653763e-05 yes 89 2.06214882436715e-08 18 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2567 aureobasidin a 60 nM 5.47200481851922 2.84481842028214e-05 yes 90 2.2248636590231e-08 22 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2160 5660466 132.927 µM 5.45127911848889 3.03703991668005e-05 yes 91 2.50044039460757e-08 6 2859134
SGTC_500 h-89 112 µM 5.41567625707289 3.3962512725609e-05 yes 92 3.05287452735362e-08 3 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2471 5466956 24.79 µM 5.36526565542584 3.97415980181005e-05 yes 93 4.04150816233966e-08 10 724419
SGTC_624 k048-0052 28 µM 5.18004977621462 6.99845120853045e-05 yes 94 1.10913349948828e-07 3 6835531
SGTC_393 acivicin 6.25 µM 5.12731982964533 8.19475015712175e-05 yes 95 1.4694800445864e-07 5 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1309 pyrazolanthrone 13.4 µM 5.10967719615069 8.63623749392097e-05 yes 96 1.61354852161674e-07 5 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2111 5486399 200 µM 5.09543375561285 9.00888385167128e-05 yes 97 1.73971837421497e-07 19 689674
SGTC_850 0388-0143 75.9 µM 5.08194933927024 9.3755585050071e-05 yes 98 1.86790530029438e-07 1 67273
SGTC_591 4299-0174 154 µM 5.07280317241826 9.63220047756345e-05 yes 99 1.95998951472713e-07 1 5509088
SGTC_2354 9060492 162 µM 5.02956517927887 0.000109373697621857 yes 100 2.45796686589497e-07 3 6471895
SGTC_2003 4023581 200 µM 4.98353685864047 0.000125081858138389 yes 101 3.12162071360077e-07 3 16641307
SGTC_2610 ononetin 44.17 µM 4.90620188750066 0.000156326344089428 yes 102 4.64284736927615e-07 2 259632
SGTC_690 glyoxal 20.3 µM 4.90203116718712 0.000158203499238197 yes 103 4.74253913922178e-07 19 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3159 9100096 49.47 µM 4.88235557228544 0.000167347110422785 yes 104 5.24130065478732e-07 1 25236875
SGTC_2743 auranofin 4.32 µM 4.85796670610203 0.000179367563793882 yes 105 5.92986726193607e-07 8 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_974 1326-0144 138 µM 4.80090463533468 0.00021071779286998 yes 106 7.89752390378019e-07 3 5411856
SGTC_916 4466-0038 42 nM 4.79878680294032 0.000211974409899009 yes 107 7.9814800742678e-07 20 5722064 YGL116W CDC20
SGTC_1394 3474-0001 65.7 µM 4.70396466982002 0.000275966916337711 yes 108 1.27578710404314e-06 2 5017666 YIL048W NEO1
SGTC_1928 4'-methoxychalcone 40.3 µM 4.67371958794349 0.000299898386163679 yes 109 1.47896563392223e-06 1 641818
SGTC_1652 st011932 78 µM 4.67150632461411 0.00030172338448755 yes 110 1.49499445474693e-06 28 1551076
SGTC_1377 2944-0135 198 µM 4.62579175692879 0.0003418090630684 yes 111 1.86585046727452e-06 4 1894137
SGTC_2278 7948257 134.34 µM 4.57221431325601 0.000395071226379851 yes 112 2.41298480537026e-06 3 1247028
SGTC_181 1447-1644 8.07 µM 4.56738529280419 0.000400232278498847 yes 113 2.46922883334534e-06 9 534600
SGTC_2662 daunorubicin 22.37 µM 4.55051816518608 0.000418754142229542 yes 114 2.67569833637091e-06 14 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_102 gallobenzophenone 83.616 µM 4.53084870963303 0.000441356231061589 yes 115 2.93735996027396e-06 3 70837
SGTC_1058 3448-5425 97.3 µM 4.47912314220207 0.000506302933973655 yes 116 3.74751441105141e-06 6 7279705
SGTC_3165 9101544 49.47 µM 4.457983305301 0.000535307927363419 yes 117 4.13671719130671e-06 1 5002184
SGTC_2495 cafestol 54.53 µM 4.43854454931151 0.00056332800762726 yes 118 4.52846199362306e-06 7 16667697 An anti-infammatory.
SGTC_397 arbidol 50 µM 4.40720282307291 0.000611375205674739 yes 119 5.23570624915397e-06 4 131410 A RNA synthesis inhibitor.
SGTC_2041 5107442 45.335 µM 4.3849654954049 0.000647730743110174 yes 120 5.80020823660108e-06 26 793005
SGTC_369 0957-0393 4.5 µM 4.27709505243956 0.000854103928743315 yes 121 9.46739839001483e-06 6 6997992
SGTC_2024 5144227 134 µM 4.26823307061654 0.000873499553177417 yes 122 9.85137046154934e-06 3 3475211
SGTC_566 0958-0068 16.5 µM 4.25044605528593 0.0009136563667063 yes 123 1.06672607883313e-05 18 6815365
SGTC_3092 9117248 49.47 µM 4.24363509365123 0.000929477201980827 yes 124 1.0996393633669e-05 2 17141857
SGTC_351 caspofungin 25 nM 4.23855654738823 0.000941437268114476 yes 125 1.12480761537202e-05 28 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3154 9100113 49.47 µM 4.19724948023993 0.00104409511422867 no 126 1.35088129421936e-05 7 25237525
SGTC_71 0417-1750 47.813 µM 4.19286165104529 0.00105558274145493 no 127 1.37728724158748e-05 8 6811472
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 4.18110466363803 0.00108693705701016 no 128 1.45048142048806e-05 7 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1826 st055655 41.6 µM 4.17555219433036 0.00110203957927499 no 129 1.48632041714639e-05 2 676168
SGTC_855 0428-0020 25 µM 4.16905416558852 0.00111995810628062 no 130 1.52933149671138e-05 6 6812414
SGTC_755 1995-0008 37.3 µM 4.14916636822004 0.0011764711135068 no 131 1.66844118539666e-05 3 689533
SGTC_72 0744-0168 198.391 µM 4.11227673098838 0.00128826077558664 no 132 1.95888144669479e-05 7 677577
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 4.09133633107076 0.00135595956692074 no 133 2.14447293072739e-05 8 688788
SGTC_3288 9119690 36.221 µM 4.07804479100074 0.00140060048885265 no 134 2.27080092349976e-05 17 17595618 YKL019W RAM2
SGTC_3232 9132874 49.47 µM 4.06641337969668 0.00144076256450971 no 135 2.38711094440379e-05 8 3784940
SGTC_2552 juarezic acid 87.02 µM 4.05627320607441 0.00147663032143258 no 136 2.49309660025555e-05 1 1549512
SGTC_1464 k208-0027 110 µM 4.05370373201359 0.00148584751984607 no 137 2.52065277585889e-05 5 X1464
SGTC_2810 7959871 45.46 µM 4.05081607155157 0.00149626874106049 no 138 2.55196578940385e-05 17 2974535
SGTC_419 nsc-638432 893 µM 4.04928940704772 0.0015018051959079 no 139 2.56866915321232e-05 4 368090
SGTC_1632 st005650 90 µM 4.00820378901356 0.00165800316618826 no 140 3.05911575988754e-05 7 2759605
SGTC_590 k048-0076 22.4 µM 3.99761009133298 0.00170060871248455 no 141 3.19926172125478e-05 10 6832814
SGTC_109 0132-0036 33.701 µM 3.99701221369624 0.00170304270239666 no 142 3.20734962647461e-05 2 67274 A color developer.
SGTC_1929 genistein trimethyl ether 50.5 µM 3.97039384649375 0.0018146749974308 no 143 3.58769603154367e-05 5 136420
SGTC_1927 st060202 13.8 µM 3.94652163366821 0.00192040755361095 no 144 3.96473800725697e-05 7 688887
SGTC_3146 9095609 49.47 µM 3.94649996726073 0.00192050600726699 no 145 3.96509663187236e-05 5 17173999
SGTC_666 0272-0154 136 µM 3.92471451653524 0.00202185321789516 no 146 4.34163260911096e-05 14 6870312
SGTC_154 3389-1638 511.116 µM 3.91036740303268 0.00209122305144031 no 147 4.60779195238227e-05 6 5238686
SGTC_997 3996-0078 137 µM 3.90084133335297 0.00213846803232461 no 148 4.7929482466245e-05 6 735687
SGTC_3087 9117406 49.47 µM 3.88091915103763 0.0022404155756629 no 149 5.20312165008919e-05 3 42546093
SGTC_1240 0356-0016 42.1 µM 3.8693237582424 0.00230176055492547 no 150 5.45688195907514e-05 7 4305613
SGTC_2749 bexarotene 57.39 µM 3.84525927828758 0.00243395209386454 no 151 6.02125177821129e-05 3 82146 An retinoic acid receptor inhibitor.
SGTC_1545 lovastatin 49.4 µM 3.79278728357465 0.0027462971549838 no 152 7.44828784032042e-05 7 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2443 5493264 126.67 µM 3.77519498268875 0.00285884822660353 no 153 7.99412766984882e-05 7 5340055
SGTC_496 calpeptin 138 µM 3.76110167124434 0.0029519966097179 no 154 8.45833234883313e-05 5 73364 A calpain inhibitor.
SGTC_2647 atorvastatin 60.16 µM 3.73913813494472 0.00310262385303278 no 155 9.23261228096251e-05 6 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_777 1315-0167 517 µM 3.7107793327062 0.00330733327185998 no 156 0.000103311080066987 4 4221767
SGTC_801 0866-0028 10.1 µM 3.70212894193424 0.00337215034327715 no 157 0.000106898954044172 10 6849771
SGTC_22 0964-0034 14.468 µM 3.66230064660778 0.00368555292501496 no 158 0.000124980128579363 29 138402
SGTC_1250 0485-0349 40.2 µM 3.65110989437825 0.00377819273274134 no 159 0.000130554738387187 14 6842794 YDL195W SEC31
SGTC_1454 4239-0054 42.6 µM 3.6484338066731 0.0038006530737449 no 160 0.000131921930464854 7 1340767
SGTC_2505 galangin 7.89 µM 3.64266011949141 0.00384951967198454 no 161 0.00013491751202265 8 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_907 3448-6986 75.5 µM 3.63524704275511 0.00391308680983675 no 162 0.000138857189103961 8 590582
SGTC_2541 muurolladie-3-one 83.07 µM 3.61837676130389 0.00406126751689927 no 163 0.000148228304795089 23 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1817 st052116 64.4 µM 3.60741206056933 0.00416024994116573 no 164 0.000154633152765238 2 4361398
SGTC_2087 5276107 200 µM 3.60144777780151 0.00421499316486546 no 165 0.000158224997079322 8 144405
SGTC_557 1315-0110 16.2 µM 3.57615989593586 0.00445432258806267 no 166 0.000174339216191714 7 6833801
SGTC_1399 3562-5772 25 µM 3.57187348918719 0.00449607192337663 no 167 0.000177218313740589 11 23847490
SGTC_257 daunorubicin 18.5 µM 3.54245168164096 0.00479219216115417 no 168 0.000198213020247757 21 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1562 morin hydrate 59.1 µM 3.54180477396059 0.0047988940114315 no 169 0.000198699737980872 10 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1727 st034309 9.9045 µM 3.52040099282517 0.00502539866907039 no 170 0.000215447413244588 20 870305
SGTC_1373 2887-0003 58.5 µM 3.51850668233649 0.00504589657455013 no 171 0.000216991442972021 17 776948
SGTC_1213 1315-0166 115 µM 3.51501262788638 0.00508390034236015 no 172 0.00021986653903774 22 768401
SGTC_2931 9014674 55.67 µM 3.49948869869847 0.00525584830095416 no 173 0.000233075682305141 8 2996810
SGTC_839 0122-0028 230 µM 3.45979235004926 0.0057192869379757 no 174 0.000270296046123975 46 759448
SGTC_2150 5556613 200 µM 3.45754864075951 0.00574653254770557 no 175 0.000272556913821598 10 743190
SGTC_1844 rapamycin 4 nM 3.45513926014151 0.00577591813051402 no 176 0.000275004328786225 66 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2699 st077704 54.6 µM 3.42931703530587 0.00609932642409967 no 177 0.000302551128590084 8 645852
SGTC_655 k060-0012 42 µM 3.42037338108247 0.00621502524052637 no 178 0.000312676197421089 12 5994525
SGTC_2276 7947513 42.08 µM 3.41528347796921 0.00628173458466759 no 179 0.000318578316692124 7 2105100
SGTC_841 0251-0215 91.2 µM 3.40745724635645 0.00638554386324881 no 180 0.000327855900411932 7 3888614
SGTC_1419 3993-2473 62.6 µM 3.40279430868921 0.00644811354339996 no 181 0.000333502374042392 10 704026
SGTC_1870 st057514 26.5 µM 3.39314771841135 0.00657928077625233 no 182 0.000345471836918763 13 5393161
SGTC_894 0960-0238 55.9 µM 3.36686585517929 0.00694868749281203 no 183 0.000380138305294305 12 6741907 YDL195W SEC31
SGTC_2049 5262831 67.185 µM 3.3661314739906 0.00695926752229239 no 184 0.000381151829220507 16 763417
SGTC_3088 9117578 49.47 µM 3.35225767675543 0.00716183318444639 no 185 0.000400776884810033 5 678341
SGTC_3020 9089140 49.47 µM 3.34915831471526 0.00720779014216661 no 186 0.00040528732656906 14 17217859
SGTC_527 4476-4215 268 µM 3.325422881816 0.00756844264082844 no 187 0.000441422597236075 7 4418754
SGTC_769 0302-0231 76 µM 3.31805102161881 0.0076836447320102 no 188 0.000453239623004984 23 571869 YER009W NTF2
SGTC_1633 st005664 67.9 µM 3.30633563586055 0.0078699011302568 no 189 0.000472623942016695 11 2063822
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 3.30217386417298 0.00793701647725605 no 190 0.000479692913880845 18 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2005 4024620 188 µM 3.28583559982301 0.00820538872067726 no 191 0.000508401681809444 7 236743
SGTC_3335 9143315 29.6265 µM 3.28523876210407 0.00821534151970147 no 192 0.000509479921265009 10 4899691
SGTC_3078 9116413 49.47 µM 3.28248758247223 0.00826135712149854 no 193 0.000514477586952431 11 17177322
SGTC_2141 5621638 7.665 µM 3.28230411525874 0.00826443378810069 no 194 0.000514812473390528 3 2856238
SGTC_60 0986-0278 202 µM 3.2807531744681 0.00829048263780486 no 195 0.000517651508686081 6 3110598
SGTC_2587 piperic acid 92.2 µM 3.27200134782635 0.00843882977740913 no 196 0.00053394533483064 14 5370536
SGTC_2136 5328288 199.296 µM 3.25353434966695 0.0087595178365395 no 197 0.000569894722050687 15 262395
SGTC_1119 parthenolide 318.541 nM 3.2431489254873 0.00894451908989127 no 198 0.00059108200785852 14 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2401 5128683 200 µM 3.23638151485502 0.00906690472581073 no 199 0.000605277352412987 21 708373
SGTC_641 4092-0595 30 µM 3.23561762043328 0.00908081110495185 no 200 0.000606899327643101 17 786260
SGTC_2161 5662504 8.5105 µM 3.2285444647144 0.00921046458796789 no 201 0.000622109573009459 15 2859334
SGTC_2320 7373003 200 µM 3.22699616747864 0.00923906062928266 no 202 0.000625485678587287 18 5415828
SGTC_2107 5363541 170.161 µM 3.20462490977311 0.00966099891159571 no 203 0.000676192975173219 17 244052
SGTC_2420 aureobasidin a 50 nM 3.20226539788437 0.00970646784899361 no 204 0.000681756563253752 6 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_469 w7 172 µM 3.20125113244894 0.00972607062692103 no 205 0.000684161091645935 7 45115570 A P450 inhibitor.
SGTC_2166 5933061 31.504 µM 3.19421332919677 0.00986304586894952 no 206 0.000701062317557302 5 2877375
SGTC_1682 st012968 530 nM 3.18799770093037 0.0099854171454472 no 207 0.000716308377918992 11 24207270
SGTC_1749 st037932 54.2 µM 3.16252898327098 0.0105007819971336 no 208 0.000782025827839116 20 594497
SGTC_922 1866-0035 480 µM 3.15514591513347 0.0106544486083254 no 209 0.000802089271004559 21 3156169
SGTC_170 4197-0004 226 µM 3.13505814629897 0.0110824962687975 no 210 0.000859100255427818 16 218692
SGTC_580 1123-0028 41 µM 3.10645143400045 0.0117178559244572 no 211 0.000946737042569014 34 1677248 YPR107C YTH1
SGTC_96 0929-0093 37.281 µM 3.10479055416624 0.0117556963885497 no 212 0.000952069031586228 13 6991579
SGTC_1101 ebselen 5.29 µM 3.0941582596197 0.0120004576150592 no 213 0.000986860858844836 14 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_783 0848-0141 92.7 µM 3.08479532492605 0.0122196446729913 no 214 0.00101846137040835 28 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3244 9134489 49.47 µM 3.06813037785356 0.0126183626594677 no 215 0.00107701308595647 14 16584271
SGTC_65 0798-0905 34.986 µM 3.06576093206274 0.0126759575248063 no 216 0.00108558419360313 18 3602145
SGTC_145 3737-0113 38.366 µM 3.05981413358776 0.0128215111900047 no 217 0.00110737195400091 75 6849351
SGTC_667 1498-1044 59 µM 3.0441406342851 0.0132120809509172 no 218 0.00116673015055398 17 6739982
SGTC_1483 3453-0561 55.9 µM 3.03856989854189 0.0133533536944654 no 219 0.00118851976861111 13 4546991
SGTC_831 k061-1017 217 µM 3.01236339292283 0.0140355828249442 no 220 0.00129611039388496 23 1240153
SGTC_1232 0279-0259 161 µM 2.98891629338543 0.0146712328470891 no 221 0.00139984410475471 19 1560000
SGTC_2262 9014885 67.46 µM 2.98630371085978 0.0147435703092836 no 222 0.00141186025312942 4 6457424
SGTC_3265 9137266 49.47 µM 2.97123365260583 0.0151668481111641 no 223 0.00148303013299806 6 17224265
SGTC_3014 9081533 49.47 µM 2.95010714777999 0.01577778691297 no 224 0.00158831871188382 20 21367265
SGTC_1005 4092-0690 4.4 µM 2.94491077114449 0.0159312508830075 no 225 0.00161523906021183 26 1529343
SGTC_2255 7941087 197.44 µM 2.94249598983198 0.0160030007500037 no 226 0.00162789001312231 15 935561
SGTC_1730 st033808 45.1 µM 2.93686053285134 0.0161715240790488 no 227 0.00165776587796921 9 1045166
SGTC_3110 9122132 49.47 µM 2.91097327147632 0.0169653294469845 no 228 0.00180152419148867 22 918317
SGTC_2231 micatex 6.853 µM 2.91088556543516 0.0169680744921294 no 229 0.00180202994655318 17 20737 An antifungal of unknown mechanism.
SGTC_717 1532-0246 73.2 µM 2.90867369150415 0.0170374279137737 no 230 0.00181482744366383 22 9561992
SGTC_1951 sophoraflavanone G 9.2 µM 2.90616622590195 0.0171163425296439 no 231 0.00182943510022072 15 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1579 chlormadinone acetate 49.4 µM 2.9022965800935 0.017238740443095 no 232 0.00185218826720419 15 45114258 A steroidal progestin.
SGTC_1059 3448-6867 171 µM 2.8987796044014 0.0173506311866261 no 233 0.00187309061308936 21 3934407
SGTC_2339 9000433 200 µM 2.89173494010815 0.0175766199535282 no 234 0.00191560511195161 17 2988954
SGTC_3089 9117425 49.47 µM 2.87484512490188 0.0181286897348441 no 235 0.00202112862009479 10 9401657
SGTC_2873 9040596 71.43 µM 2.86550825577805 0.0184401750696502 no 236 0.00208170208376562 26 6463863
SGTC_2069 5228469 200 µM 2.83134171921727 0.0196191421157801 no 237 0.00231765846130348 14 2835210
SGTC_1613 st002381 52.1 µM 2.82151996121089 0.0199696765912102 no 238 0.00238983314322021 19 551167
SGTC_237 nikkomycin 200 µM 2.81330172263739 0.0202670516712311 no 239 0.00245178082856854 21 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2445 5742597 35.57 µM 2.80907569544171 0.0204214255665373 no 240 0.00248419816186293 25 1774255
SGTC_1679 SEC14.276 6.7 µM 2.79690486803301 0.0208715957370181 no 241 0.00257973612590873 45 1005053 YMR079W SEC14
SGTC_209 4077-0173 175.592 µM 2.79248482696831 0.0210371488487361 no 242 0.00261524602946394 4 15993494
SGTC_151 3013-0144 2.285 µM 2.79094497597645 0.0210950845159116 no 243 0.00262772028576395 30 906558 YHR107C CDC12
SGTC_1385 3091-4834 14.1 µM 2.78865805542976 0.0211813771647875 no 244 0.00264634572130136 17 4072814
SGTC_2400 5203494 178.7 µM 2.78395712957014 0.021359695765901 no 245 0.00268500657107285 38 6777674
SGTC_1991 st073000 8.92 µM 2.78143862169673 0.0214557505235293 no 246 0.00270592815619258 37 4301969 YIL048W NEO1
SGTC_1271 0832-2808 169 µM 2.77285614555389 0.0217858290946993 no 247 0.00277833392809642 30 3663794
SGTC_1468 k284-1086 134 µM 2.77191272359725 0.0218223730040217 no 248 0.0027863987984216 30 15996457
SGTC_2370 9071495 200 µM 2.77162172377855 0.0218336554661525 no 249 0.00278889067821651 25 21791103
SGTC_789 1309-1135 70.6 µM 2.76789377533717 0.0219786294914838 no 250 0.00282099207940954 15 3092424
SGTC_2380 9035439 200 µM 2.76063182430094 0.0222633695334248 no 251 0.00288448354240008 18 6462575
SGTC_1941 st076221 61.8 µM 2.74964117368175 0.0227002273543561 no 252 0.00298302785499019 30 2828568
SGTC_2387 9077560 195.08 µM 2.74761794006841 0.0227814294977683 no 253 0.00300149572883346 31 5303272
SGTC_1740 st038286 13.222 µM 2.74562044519187 0.022861838607123 no 254 0.00301982965390649 28 716786
SGTC_1631 benzylvanillin 81.9 µM 2.73369246242131 0.0233469920622211 no 255 0.00313142548605809 18 75506
SGTC_233 rapamycin 362 pM 2.73309771860102 0.023371407482196 no 256 0.00313708573548977 10 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2563 tomatine 8.54 µM 2.72006773869931 0.0239117298748263 no 257 0.00326342721836926 35 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2694 st077685 81.9 µM 2.71821595310164 0.0239893645011391 no 258 0.00328174920569373 19 2838096
SGTC_546 peri-Naphthalide 147 µM 2.7088871525444 0.0243836953317988 no 259 0.00337546486095262 55 223824 A penicillin ester.
SGTC_2189 6047310 154.431 µM 2.70324035137934 0.0246250205949274 no 260 0.00343335365642498 16 711535
SGTC_3109 9122853 49.47 µM 2.68206488370458 0.0255479094714005 no 261 0.0036584633443549 10 1234709
SGTC_691 1548-0686 185 µM 2.68131159112605 0.0255812665531393 no 262 0.00366670984886389 36 46495133
SGTC_2543 pimpinellin 60.67 µM 2.67816043592082 0.0257212006740619 no 263 0.00370138751558616 12 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_130 0136-0219 337.655 µM 2.67582394853222 0.0258253708098438 no 264 0.00372728959457586 24 234244
SGTC_2433 5607874 27.82 µM 2.67374705145596 0.0259182635143908 no 265 0.00375045023040423 18 2252428
SGTC_1002 4049-0206 172 µM 2.6588337798162 0.0265935276887322 no 266 0.00392058188859508 31 4662749
SGTC_804 1595-0054 20.9 µM 2.65752394259085 0.0266535321329327 no 267 0.00393584994187262 22 761523 Stimulates phospholipase C.
SGTC_529 4076-0302 30.3 µM 2.65720594288475 0.026668116942344 no 268 0.0039395647154625 24 5816522
SGTC_1736 st036774 51 µM 2.65579502651086 0.0267329079492895 no 269 0.0039560845084902 21 1272247
SGTC_2874 9043904 71.43 µM 2.6496391427202 0.0270171336370076 no 270 0.00402888921846929 19 4463428
SGTC_3012 9080433 71.4286 µM 2.64452041388669 0.0272553888970187 no 271 0.0040903385993599 22 17688859
SGTC_1448 4255-0083 152 µM 2.63262688562651 0.0278157559775822 no 272 0.00423636841851089 30 5399660
SGTC_2157 5649910 96.377 µM 2.62457628947086 0.0282004840476381 no 273 0.00433784273192916 27 2858091
SGTC_2906 7926292 26.41 µM 2.61723071940618 0.0285553747662733 no 274 0.00443232004858356 15 2966319
SGTC_3130 9127414 49.47 µM 2.61565817048553 0.0286318310412177 no 275 0.00445278317183766 20 1494646
SGTC_1208 2323-2347 50.3 µM 2.60780132426537 0.0290163802432327 no 276 0.00455629137458187 7 5412760
SGTC_759 3486-0358 89.3 µM 2.60540919613112 0.0291343104878262 no 277 0.00458822967847792 22 875103
SGTC_602 3130-1533 38.1 µM 2.60459705650051 0.0291744388363241 no 278 0.00459911824467577 36 720941
SGTC_2520 obtusaquinone 4.71 µM 2.60335408395416 0.0292359438228748 no 279 0.00461582776202788 26 5967872
SGTC_2254 7938975 95.19 µM 2.60296142692483 0.0292553957177298 no 280 0.00462111757497737 30 2969277
SGTC_1133 3473-0247 50 µM 2.59738897446673 0.0295326109152086 no 281 0.00469677411722988 81 711311
SGTC_508 roscovitine 141 µM 2.59658888267856 0.0295725918614052 no 282 0.00470772710559139 10 160355 A CDKinase inhibitor.
SGTC_2614 arthonioic acid 13.39 µM 2.58972904073766 0.0299172283838556 no 283 0.00480257511128784 16 6710684
SGTC_606 k015-0008 38.6 µM 2.58959378982362 0.0299240566965484 no 284 0.00480446217121555 20 1970475
SGTC_1614 st002383 48.6 µM 2.5774171990558 0.0305441250035004 no 285 0.004977086340726 12 1947235
SGTC_1102 cgs 12066b 26.1 µM 2.57638185353367 0.0305973352627381 no 286 0.00499201595271018 21 6438352 A 5-HT1B full agonist.
SGTC_2361 9034121 116 µM 2.56530174865465 0.0311716047632105 no 287 0.00515430561905759 51 6496917
SGTC_3120 9124077 49.47 µM 2.56124694818758 0.0313839766248911 no 288 0.00521485954760147 22 18774327 YGL155W CDC43
SGTC_1021 4476-0760 85.3 µM 2.54412771401474 0.0322938324513248 no 289 0.00547755107255562 12 746768
SGTC_1950 st077106 7.18 µM 2.54367050495534 0.032318427626093 no 290 0.0054847252701475 22 13831864
SGTC_829 1635-0120 117 µM 2.53914541807498 0.032562685425382 no 291 0.00555618120519785 76 285054
SGTC_1285 0929-0069 65.5 µM 2.53807837171895 0.0326205044003941 no 292 0.00557315102132794 18 1206237
SGTC_1608 st001473 40.5 µM 2.53219389938226 0.0329408832650816 no 293 0.00566756451808498 38 7292267
SGTC_3299 9121982 43.1275 µM 2.52355018219368 0.0334161871154573 no 294 0.00580882389014864 27 17594604 YPL160W CDC60
SGTC_33 0986-0033 35.816 µM 2.51307133621014 0.0339999592113074 no 295 0.00598425653914308 12 2848082
SGTC_2853 9015042 58.44 µM 2.51140282029798 0.0340936810213367 no 296 0.00601261950710182 23 6457456
SGTC_3338 9144300 39.5675 µM 2.50931657143893 0.0342111659521823 no 297 0.00604825109179724 17 4901274
SGTC_724 3910-0327 137 µM 2.50830893342166 0.0342680291096887 no 298 0.00606552773096191 32 2885483
SGTC_2194 5927483 104.545 µM 2.50818863316585 0.0342748230970517 no 299 0.00606759328035292 25 760979
SGTC_1080 nisoldipine 24.4 µM 2.49211119068066 0.0351928114828663 no 300 0.00634931385409614 32 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2934 9036370 36.88 µM 2.48491540379086 0.0356101609198232 no 301 0.00647911121007831 19 6462800
SGTC_104 0074-0074 590.992 µM 2.48200793716871 0.0357799382860697 no 302 0.00653221826375228 45 3943124
SGTC_1966 st070145 16.1 µM 2.47972714430295 0.0359135856860942 no 303 0.00657414774194513 29 3748532
SGTC_2337 9009472 200 µM 2.47941181891251 0.0359320949143845 no 304 0.00657996328501159 34 5742383
SGTC_417 st075190 100 µM 2.47559759854627 0.0361566047110722 no 305 0.00665067005700325 23 222757
SGTC_2348 9022543 33.42 µM 2.46988593088322 0.0364949472852503 no 306 0.00675780710330013 70 3162678 YDL140C RPO21
SGTC_1362 1611-0397 101 µM 2.46922704360346 0.03653414397709 no 307 0.00677026381300235 30 27816
SGTC_631 k072-0230 41.5 µM 2.4691840639886 0.0365367019971985 no 308 0.00677107707607764 23 5773147
SGTC_1748 st037455 53.6035 µM 2.45585066797141 0.0373373695151236 no 309 0.00702757747872387 30 580690
SGTC_1622 st003707 19.4 µM 2.45570377200893 0.0373462697741453 no 310 0.00703045050289206 32 10140899
SGTC_195 4234-0266 16.654 µM 2.44840933728312 0.0377904156486783 no 311 0.00717442682788142 49 2303354
SGTC_2321 7390090 138.78 µM 2.44561426680618 0.0379617411832505 no 312 0.00723028089312066 24 649046
SGTC_1141 3253-0389 52.6 µM 2.44468299450805 0.0380189646307208 no 313 0.00724897554425625 27 5402031
SGTC_2507 purpurin 79.67 µM 2.44419251418213 0.0380491312217921 no 314 0.00725883872509795 32 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_899 1083-0020 478 µM 2.43912640319647 0.0383618620215838 no 315 0.0073614086802387 30 767123
SGTC_1756 st041558 35.5 µM 2.43278359218227 0.0387563542229489 no 316 0.00749162651353143 25 3955792
SGTC_185 k048-0037 25.491 µM 2.42393612167286 0.0393121374636389 no 317 0.00767665291397662 14 6827589
SGTC_3267 9137951 49.47 µM 2.41395990217361 0.0399465881019303 no 318 0.00789009943878713 14 16643986
SGTC_332 4112-0506 40.9 µM 2.41167874118974 0.040092824314944 no 319 0.00793963316466782 59 2790355
SGTC_1670 st016595 4.04 µM 2.41150312904368 0.0401041001230921 no 320 0.00794345776472475 26 597879
SGTC_1168 k815-0004 80.5 µM 2.40022408364771 0.0408337258896207 no 321 0.00819251902576788 54 642433
SGTC_432 NS 1619 61.3 µM 2.39823230122067 0.0409636835498429 no 322 0.00823720677966836 34 4552 A K+/calcium channel activator.
SGTC_2737 bleomycin 30.5 nM 2.3976425125075 0.0410022297570349 no 323 0.00825048033840543 34 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_825 1988-2224 89.6 µM 2.38804912755421 0.0416333555450102 no 324 0.00846903870474993 42 1180859
SGTC_822 1487-0950 154 µM 2.37920695647296 0.0422220082617421 no 325 0.00867496598945559 25 1958375
SGTC_1706 st031321 9.9705 µM 2.37779109387048 0.0423168894690182 no 326 0.00870834500037418 21 6103185
SGTC_1514 1189-1591 158 µM 2.37681992439511 0.0423820701347855 no 327 0.00873130542114914 36 767698 YMR146C TIF34
SGTC_2747 doxorubicin 7.63 µM 2.37678054515665 0.0423847148100878 no 328 0.00873223754510228 23 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_827 3253-0474 693 µM 2.37665915285744 0.0423928682510433 no 329 0.00873511150344432 36 5402065
SGTC_1274 0865-0114 173 µM 2.37006102798543 0.0428379502195867 no 330 0.00889257467326761 38 870624
SGTC_3073 9114972 49.47 µM 2.36646059822001 0.0430824083231169 no 331 0.00897954289749943 26 41905075
SGTC_3256 9138902 49.47 µM 2.3640202427728 0.0432487408122062 no 332 0.00903891238798496 10 17228773
SGTC_750 4073-0104 132 µM 2.36037650109231 0.043498059912066 no 333 0.00912819794981129 13 22330957
SGTC_2300 7976697 71.57 µM 2.35293935678365 0.0440105388375379 no 334 0.00931283571678503 24 2236109
SGTC_1771 st048882 4.1505 µM 2.35246751037232 0.0440432164036556 no 335 0.00932465944429677 43 4580403
SGTC_2030 5175110 200 µM 2.33632241447081 0.0451731767895952 no 336 0.00973722208562169 24 2831986
SGTC_2875 9039966 71.43 µM 2.32834996658861 0.0457396923747853 no 337 0.0099467640514673 17 6463691
SGTC_2964 9083345 53.42 µM 2.32626820414039 0.0458885571390601 no 338 0.0100021235702989 54 17741579
SGTC_1647 st011722 22.4 µM 2.32163183710611 0.0462214982662208 no 339 0.0101263840407915 33 2854783
SGTC_2822 7994718 71.43 µM 2.32121755362421 0.0462513424558878 no 340 0.0101375526340784 34 1018011
SGTC_3115 9123671 49.47 µM 2.31930881639908 0.0463890441674147 no 341 0.0101891488673958 23 3286988
SGTC_2753 fluvastatin 17.09 µM 2.316642704517 0.046581935742577 no 342 0.0102616015297136 43 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1434 4073-0095 163 µM 2.31633529924584 0.0466042176528735 no 343 0.0102699842109052 24 24133745
SGTC_1665 st014639 11.4 µM 2.31362582416534 0.0468009808952986 no 344 0.0103441279402268 35 981133 YIL048W NEO1
SGTC_1109 tnp00067 928.257 nM 2.30383705315418 0.0475174042601273 no 345 0.0106158961463828 23 676295
SGTC_605 1315-0399 119 µM 2.30279557833087 0.0475941423494497 no 346 0.0106451737172396 41 24020461
SGTC_3051 9093778 49.47 µM 2.29803448848487 0.0479462145894942 no 347 0.0107799131435522 26 17217378
SGTC_2051 5263410 176 µM 2.29779038254403 0.0479643217265446 no 348 0.0107868612072187 31 227584
SGTC_2966 9084041 48.03 µM 2.29537619373157 0.0481436948062565 no 349 0.0108557872247248 25 17741380
SGTC_1943 st076331 65.2 µM 2.28667190341734 0.0487948798632406 no 350 0.011107490422465 21 24208415
SGTC_1813 st051246 8.6015 µM 2.28597603935687 0.0488472412350293 no 351 0.0111278301750555 22 5291959
SGTC_2031 5180455 200 µM 2.27822759679544 0.0494333233692735 no 352 0.011356510434686 27 29949
SGTC_1380 2291-0730 164 µM 2.26493644243686 0.0504517087636476 no 353 0.0117582900261393 30 2999191
SGTC_2343 7990716 14.84 µM 2.26349835075151 0.0505628921857459 no 354 0.0118024930813035 34 6456862
SGTC_868 0527-0199 213 µM 2.25939626846404 0.0508811098310586 no 355 0.0119293731606217 35 2849450
SGTC_971 1315-0384 26.7 µM 2.25359935283617 0.0513335199193962 no 356 0.0121106920458648 35 6769120
SGTC_2286 7945697 125 µM 2.251745742639 0.051478854949315 no 357 0.012169172098812 40 1245733
SGTC_2970 9090938 41.86 µM 2.25155879453843 0.0514935310372142 no 358 0.0121750837403253 41 17217104
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.239543802676 0.052443749437111 no 359 0.0125602772904942 45 23847180
SGTC_1744 st037937 38.9 µM 2.23656673619381 0.0526813327727045 no 360 0.0126573355047462 33 1016152
SGTC_322 k048-0136 19.3 µM 2.23633840803283 0.0526995895965251 no 361 0.0126648061794626 42 6823282
SGTC_2187 6125751 200 µM 2.23613478989765 0.0527158748731508 no 362 0.0126714715847741 48 874498
SGTC_244 nsc-207895 1.295 µM 2.23047660354391 0.0531700130313712 no 363 0.0128579095031451 9 42640
SGTC_2308 7584454 197.62 µM 2.2266017958236 0.0534827987824241 no 364 0.0129869494195312 60 893577
SGTC_1336 1486-0901 104 µM 2.22151092411838 0.0538959628268333 no 365 0.0131581878191746 23 5006114
SGTC_88 0180-0332 8.668 µM 2.21606076978292 0.0543410821420557 no 366 0.0133436702584463 40 3101745
SGTC_1955 wogonin 32.4 µM 2.21032056823224 0.0548130292799664 no 367 0.0135414610674604 32 5281703 A flavanone.
SGTC_918 glabranin 770.725 nM 2.2091493384581 0.0549097221094494 no 368 0.0135821276615551 33 124049 Also referred to as licorice root.
SGTC_1286 0929-0070 131 µM 2.20746289002617 0.055049186411962 no 369 0.0136408684328386 34 1420408
SGTC_2640 pentamidine 10.38 µM 2.20729587606024 0.0550630131905947 no 370 0.0136466976169162 56 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2144 5628481 200 µM 2.20685815466892 0.055099264358014 no 371 0.0136619853330205 23 2818399
SGTC_1723 st034307 2.5525 µM 2.20627791252509 0.0551473478555405 no 372 0.0136822734589112 64 867466
SGTC_281 1672-3440 14.9 µM 2.20483821790994 0.0552667956088143 no 373 0.0137327245769707 29 6833000
SGTC_1905 st060207 84.5 µM 2.19409533068696 0.0561645678710031 no 374 0.0141142784430071 37 1948547
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.18764433106788 0.0567091728682966 no 375 0.0143477600084828 28 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2742 clothiapine 36.27 µM 2.17900589755118 0.0574449498712469 no 376 0.0146656150520762 22 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2979 9012552 45.46 µM 2.17804043342581 0.0575276475692138 no 377 0.0147015133170766 26 17100905
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.1762091652191 0.0576847637323199 no 378 0.014769811953947 49 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2864 9034755 47.6 µM 2.16349161518051 0.058785210085635 no 379 0.0152516939727128 32 4930451
SGTC_1341 1486-1360 280 µM 2.16107442299689 0.0589962204550872 no 380 0.0153447954754354 44 3976547
SGTC_2373 9071805 200 µM 2.15421913120858 0.0595978907031032 no 381 0.0156114956202195 33 10149009
SGTC_1712 st032288 53.4 µM 2.15389030204269 0.0596268715588202 no 382 0.0156243878396615 81 2883011
SGTC_2996 9066192 71.4286 µM 2.14910645646858 0.0600497385929818 no 383 0.015812981037821 43 6472854
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.1417504830961 0.0607045455589474 no 384 0.016106782986435 36 616764
SGTC_1575 cyproterone acetate 48 µM 2.13378319803801 0.0614200556742517 no 385 0.0164302659486252 39 9880 An androgen receptor antagonist and liver toxin.
SGTC_2797 7859098 81.82 µM 2.12987927915736 0.0617730475298829 no 386 0.016590790624036 41 972681
SGTC_3239 9133757 49.47 µM 2.1291371619645 0.061840328463824 no 387 0.0166214569779462 19 17036923
SGTC_2857 9024691 58.44 µM 2.12086819953708 0.0625938740010885 no 388 0.016966447727599 37 16478292
SGTC_2940 9060638 45.86 µM 2.11543472239832 0.0630929074607376 no 389 0.0171964565151371 39 4027022
SGTC_2990 9074105 71.4286 µM 2.11233015333055 0.0633794320600852 no 390 0.0173290706377387 42 6502001
SGTC_743 1275-0778 158 µM 2.10623224599687 0.0639451631307877 no 391 0.017592091710155 59 2849257 YMR203W TOM40
SGTC_2418 pentamidine 31.67 µM 2.10502418408386 0.0640577052555902 no 392 0.0176446014784616 65 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2459 5811157 9.22 µM 2.10144020877788 0.0643924918960021 no 393 0.0178011707195267 38 2870684 YBR192W RIM2
SGTC_1436 4092-1007 8.32 µM 2.10100569568086 0.0644331729122646 no 394 0.0178202331352477 34 2881121
SGTC_842 0271-0008 11.1 µM 2.09909579713585 0.0646122227958646 no 395 0.017904228433005 55 1221709
SGTC_2714 st079313 56.9 µM 2.09542468999336 0.0649574681919488 no 396 0.0180666283115474 35 2939799
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.09274951854944 0.0652099525653689 no 397 0.0181857601569731 57 5393153
SGTC_2095 5432005 200 µM 2.09228407024561 0.0652539595350686 no 398 0.0182065559199992 41 783734
SGTC_969 1313-0238 134 µM 2.07605297338827 0.0668030260093549 no 399 0.0189445259375326 85 5212874
SGTC_587 k089-0003 57 µM 2.07601250120103 0.0668069238554165 no 400 0.0189463974005876 28 9659696
SGTC_3107 9121808 49.47 µM 2.07424727749168 0.0669771025027666 no 401 0.0190281757536465 34 662681
SGTC_3290 9121031 71.43 µM 2.07408778989214 0.0669924946097169 no 402 0.0190355791744547 33 17014854
SGTC_1973 st070275 50.2 µM 2.06620003843662 0.0677571584499191 no 403 0.0194047976183861 28 17118334
SGTC_893 0958-0369 48.9 µM 2.06353776273672 0.0680167641682375 no 404 0.0195307819068726 47 6819948
SGTC_620 0109-0052 432 µM 2.05979785804583 0.0683827487045669 no 405 0.0197089347208165 43 493037
SGTC_2193 5925765 200 µM 2.05902864387155 0.0684582115374044 no 406 0.0197457472965407 34 877370
SGTC_1467 k284-1082 293 µM 2.05809615442292 0.0685497784246653 no 407 0.0197904520503345 42 3334705
SGTC_2943 9068529 45.32 µM 2.05578050887125 0.0687775745220076 no 408 0.0199018387939385 75 3270634
SGTC_213 1246-0773 967 nM 2.05277428984013 0.0690741743140554 no 409 0.0200472365736649 31 6251622
SGTC_2896 9052656 71.43 µM 2.0506780344356 0.0692815778454127 no 410 0.0201491557207768 83 6469436
SGTC_3334 9142812 21.919 µM 2.04960734219816 0.0693876970789004 no 411 0.0202013816848736 55 45283678
SGTC_2592 piperlongumine 83.33 µM 2.03758767247221 0.0705876066490715 no 412 0.0207955929560525 49 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2679 rapamycin 1 nM 2.03009989853256 0.0713431254027983 no 413 0.0211731929242839 110 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2872 9044037 25.97 µM 2.02468633723365 0.0718932104161942 no 414 0.0214497912244192 27 6465195
SGTC_2907 7721985 69.9 µM 2.02349439823228 0.0720147619737274 no 415 0.0215111002712368 50 3267881
SGTC_3134 9127454 49.47 µM 2.02258233456704 0.0721078787668862 no 416 0.0215581135107605 23 24262820
SGTC_272 doxorubicin 8.13 µM 2.0139645686215 0.0729922676518769 no 417 0.0220066267829693 52 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2791 5663188 71.43 µM 2.0100111582731 0.0734007495453377 no 418 0.0222150039488581 67 54690634
SGTC_3201 9113999 49.47 µM 2.00565294330921 0.0738530810184931 no 419 0.0224466445261054 54 16649224
SGTC_2765 myclobutanil 7.74 µM 2.00376134211936 0.0740500686748159 no 420 0.0225478158638265 65 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2517 totarol 10 µM 2.00294212957454 0.0741355043309996 no 421 0.022591750194307 43 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2084 5306078 60.6385 µM 1.99692350031138 0.0747654972842552 no 422 0.0229167469427359 50 679340
SGTC_174 3553-0389 74.3 µM 1.99161032372503 0.0753250352897718 no 423 0.0232069148868387 53 738071
SGTC_925 2064-1272 59.6 µM 1.98976776130995 0.0755198217279389 no 424 0.0233082621585053 61 6815817
SGTC_3169 9102970 49.47 µM 1.98275506821176 0.0762646799210748 no 425 0.023697397569635 34 17027839
SGTC_2628 lathosterol 100 µM 1.97965202687105 0.0765960505247998 no 426 0.0238713213012664 60 6710616
SGTC_3214 9129694 49.47 µM 1.97803221487751 0.0767694630462575 no 427 0.023962536276344 60 17158655
SGTC_1515 3460-0031 42.1 µM 1.97621825887502 0.0769640142318747 no 428 0.0240650313915018 63 2876596
SGTC_856 0433-0016 11.3 µM 1.97516130009342 0.0770775482992028 no 429 0.024124923068011 39 3911780
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.97444126316252 0.0771549644939817 no 430 0.0241657950169233 51 16623 A steroid.
SGTC_1819 st053448 58.6 µM 1.97330737216593 0.07727699678761 no 431 0.024230276755941 58 2857616
SGTC_2322 7413319 38.22 µM 1.9682952184018 0.077818174914008 no 432 0.0245170399041957 83 1840400
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.96675663884968 0.0779848759107453 no 433 0.0246056368611464 42 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_885 0865-0106 16.8 µM 1.96141788151393 0.0785654176554092 no 434 0.024915147873908 62 2793380
SGTC_1210 3013-0140 750 nM 1.96004805486723 0.0787149007246391 no 435 0.0249950869086535 43 905973
SGTC_1978 st071761 42 µM 1.95857091054487 0.0788763363011436 no 436 0.0250815295329836 58 5147680
SGTC_2496 diffractaic acid 79.83 µM 1.95366828852382 0.0794139367023466 no 437 0.0253702294504747 62 94870 An apoptosis inducer which activates caspases.
SGTC_2070 5230947 200 µM 1.95269283347019 0.0795212309135778 no 438 0.025428001697798 40 2835538
SGTC_16 erodoxin 22.806 µM 1.94812324886512 0.0800253188644347 no 439 0.025700108794497 94 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3247 9135149 49.47 µM 1.93978205510763 0.0809516914592328 no 440 0.0262030911987036 94 8934436 YOR116C RPO31
SGTC_1180 1193-0155 285 µM 1.93560508214926 0.0814186168567679 no 441 0.0264580437302197 50 2921347
SGTC_1752 st044819 83.042 µM 1.93279730154236 0.081733626054295 no 442 0.026630586452741 59 441209 YML126C ERG13
SGTC_1980 st071811 45.7 µM 1.93279374762472 0.0817340253550946 no 443 0.0266308054409811 52 4974850
SGTC_108 0509-0257 621.132 µM 1.93044681736204 0.0819980362128006 no 444 0.0267757493912405 72 536624
SGTC_2942 9052777 62.25 µM 1.9299639042714 0.0820524396890563 no 445 0.0268056551728546 74 6469503
SGTC_187 1488-2104 32.728 µM 1.92916171044084 0.0821428724341536 no 446 0.026855394976398 52 2852859
SGTC_1547 harmine 94.2 µM 1.92835324324275 0.0822340883286665 no 447 0.0269056016995728 78 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2241 6772625 37.8075 µM 1.92818801795695 0.0822527393757678 no 448 0.0269158720132717 55 2285411
SGTC_3011 9081274 71.4286 µM 1.92769674202033 0.0823082146623931 no 449 0.0269464287917611 54 6625322
SGTC_2309 7664088 163.95 µM 1.92686170883709 0.0824025719429058 no 450 0.0269984332995846 61 704922
SGTC_1789 tunicamycin 25 nM 1.92126779318747 0.0830367759658606 no 451 0.0273489776389461 75 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2513 baicalein 25.65 µM 1.91589818973943 0.0836489954237984 no 452 0.0276890279835433 53 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2181 6316240 54.2555 µM 1.9139244448286 0.0838748838229595 no 453 0.0278149052315973 48 12779990
SGTC_3072 9116419 49.47 µM 1.91364755877334 0.0839066090980014 no 454 0.0278326019480929 57 17170162
SGTC_309 k408-0051 1.48 µM 1.90875752295406 0.0844683895319066 no 455 0.0281466893952145 106 3640463
SGTC_3227 9130768 49.47 µM 1.9031671003732 0.0851140839994536 no 456 0.0285093722911224 37 17720899
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.90279668400296 0.0851569974397928 no 457 0.0285335400420631 61 390807
SGTC_1276 0871-0068 94.2 µM 1.90243101685941 0.0851993765739504 no 458 0.0285574146442819 62 3414906
SGTC_640 3381-0960 37.1 µM 1.90232179595585 0.0852120378370538 no 459 0.0285645489571493 59 1745025
SGTC_593 1203-0218 61.7 µM 1.90121888521032 0.0853399700535234 no 460 0.0286366742281 58 3666956
SGTC_254 nsc-64875 3.808 µM 1.8972201365524 0.0858050118192404 no 461 0.0288994451370935 37 56993
SGTC_484 loperamide 105 µM 1.89527517471664 0.0860318892174505 no 462 0.0290279776542765 18 3955 An opioid-receptor agonist.
SGTC_299 1273-0059 1.44 µM 1.89455132691978 0.0861164396776594 no 463 0.0290759341640704 46 2848077
SGTC_2923 7992654 58.14 µM 1.89109737150269 0.0865207418622361 no 464 0.0293056736720686 62 2985126
SGTC_1446 4239-0190 62 µM 1.88287442266142 0.0874889857611965 no 465 0.0298586941087586 67 1340085
SGTC_1623 st003709 20.3 µM 1.87897328874666 0.0879511587913006 no 466 0.0301240702811454 54 16192618
SGTC_1857 st056007 79.3 µM 1.87178970984207 0.0888069669239843 no 467 0.0306178512260256 37 619834
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.87167770677268 0.0888203592116077 no 468 0.03062560278675 64 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1983 st071813 46.9 µM 1.87092389323801 0.0889105323594328 no 469 0.0306778153541084 56 11838595
SGTC_1183 1254-0324 198 µM 1.87060405829446 0.0889488124390131 no 470 0.0306999908438276 41 5799357
SGTC_1395 3486-0190 4.35 µM 1.86738042566874 0.0893353245552521 no 471 0.0309242406627152 58 6748079
SGTC_1034 k072-0165 12.7 µM 1.86737260949813 0.0893362632266235 no 472 0.0309247860324405 58 5835461
SGTC_3274 9138298 49.47 µM 1.86672816971718 0.0894136815065574 no 473 0.030969778915087 67 17015756
SGTC_2127 5253358 187.912 µM 1.86172597564879 0.0900163062481132 no 474 0.0313208626187877 60 20612
SGTC_2841 9004761 38.96 µM 1.85907928849734 0.0903363764698188 no 475 0.0315079502669499 48 2991039
SGTC_1655 st012546 55.1 µM 1.85395845690594 0.0909580491578144 no 476 0.0318725518130439 49 720985 YLR208W SEC13
SGTC_1043 0916-0009 19.3 µM 1.85355647251234 0.091006984373065 no 477 0.0319013198913484 65 3101130
SGTC_1860 st056228 74.6 µM 1.84936262332473 0.0915186840447544 no 478 0.0322027343537199 76 688679
SGTC_531 3788-1495 174 µM 1.84803445889727 0.0916811796964691 no 479 0.0322986790202306 50 2896655
SGTC_2762 leflunomide 42.06 µM 1.8472490737723 0.0917773689750356 no 480 0.0323555250103328 76 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1050 3232-1156 69.3 µM 1.84367677106276 0.0922158267371597 no 481 0.0326151301363559 86 700529
SGTC_445 e6 berbamine 66 µM 1.84206666846768 0.0924139538690165 no 482 0.0327326993035624 94 6610268 A calcium/calmodulin antagonist.
SGTC_1236 0330-0013 258 µM 1.83762889559406 0.0929616631099952 no 483 0.0330585539518908 50 4617066
SGTC_1112 tnp00069 1.16933 µM 1.83673303988914 0.0930725199990602 no 484 0.0331246576008199 53 145826
SGTC_1843 st055809 45.5 µM 1.83473882012749 0.0933196437818107 no 485 0.0332721987055439 61 16413835
SGTC_1964 st076914 61 µM 1.83413797674364 0.0933941952614521 no 486 0.0333167576849488 75 24208661
SGTC_1082 camptothecin 424.86 nM 1.83091495768065 0.0937948522860862 no 487 0.0335566187013864 85 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_217 ketoconazole 989 nM 1.82963293446557 0.0939545742228408 no 488 0.0336524227566584 58 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3277 9138724 49.47 µM 1.82086016251134 0.0950529267111833 no 489 0.0343140581042253 60 15943418
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.81898063806494 0.0952894687342566 no 490 0.0344571920313384 62 5377381
SGTC_1489 4065-0444 182 µM 1.81497576470172 0.095794935367419 no 491 0.0347638169851642 49 2877968
SGTC_99 0109-0120 622.8 µM 1.81448397458817 0.0958571413370996 no 492 0.0348016238716052 56 759414
SGTC_1214 0358-0031 63.7 µM 1.81429996232221 0.0958804244751957 no 493 0.0348157786856392 69 4301366
SGTC_1440 4100-1550 40 µM 1.81426127064095 0.0958853206767332 no 494 0.0348187555752823 57 742806
SGTC_358 0075-0058 9.45 µM 1.8110802918136 0.0962884838740218 no 495 0.0350642118896119 68 1069125
SGTC_447 ml7 120 µM 1.80991972803617 0.0964358856712739 no 496 0.0351541181550731 39 4216 Selective myosin light chain kinase inhibitor.
SGTC_435 c-PAF 6.7 µM 1.80383978523797 0.0972108020407561 no 497 0.0356282134257038 72 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1597 7-benzyloxygramine 47.5 µM 1.80077453697954 0.0976032100252727 no 498 0.0358692119086018 113 260807
SGTC_2731 amoxapine 43.43 µM 1.79814368398749 0.0979409327106018 no 499 0.0360771205940922 47 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1993 st073995 70.8 µM 1.79257295284955 0.0986588727361258 no 500 0.0365206172155091 68 3098394
SGTC_202 3594-0513 34.79 µM 1.79172311831428 0.0987687347797993 no 501 0.0365886647099325 65 708429
SGTC_726 3448-4391 34.2 µM 1.78672985481163 0.0994160458362164 no 502 0.0369905806759794 66 1356692
SGTC_3077 9117319 49.47 µM 1.7830111809864 0.0999001339402128 no 503 0.0372922416331923 61 17154678
SGTC_1518 st038567 90.8 µM 1.77652102985623 0.100749126722935 no 504 0.0378235394222647 54 77966
SGTC_2671 danthron 100 µM 1.77154028252201 0.101404230327678 no 505 0.0382354501013766 91 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3079 9117512 49.47 µM 1.77043452500862 0.101550087450995 no 506 0.0383273913062285 57 7185044
SGTC_1007 4101-0031 70 µM 1.76734872198348 0.101957934380578 no 507 0.038584922467131 79 1146276
SGTC_2997 9067075 71.4286 µM 1.76707417063955 0.101994279171171 no 508 0.0386079037848834 91 27209819
SGTC_2463 5473429 200 µM 1.76650576827812 0.102069553582588 no 509 0.0386555173474252 54 5399405
SGTC_1774 st048371 48.465 µM 1.76496852393735 0.102273335717716 no 510 0.0387845279438968 89 4242727
SGTC_3161 9100388 49.47 µM 1.7620770764501 0.102657436904647 no 511 0.0390281378949026 66 25236368
SGTC_1761 st044296 37 µM 1.76177228980128 0.102697985905679 no 512 0.0390538891714418 74 1826700
SGTC_2677 mitomycin C 100 µM 1.75929154502709 0.103028458724984 no 513 0.0392640009767504 66 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_698 k064-0052 127 µM 1.758132822709 0.10318308249628 no 514 0.0393624560700061 62 5088751
SGTC_2168 5727979 200 µM 1.75653102778802 0.103397108743411 no 515 0.0394988891239952 71 695210
SGTC_1067 clotrimazole 1.36 µM 1.7554799949929 0.103537719066816 no 516 0.0395886197788018 83 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2984 9022109 38.96 µM 1.75388105395706 0.103751896257376 no 517 0.0397254453146421 69 6459207
SGTC_1700 st030840 7.9285 µM 1.74476552044513 0.104979057563908 no 518 0.0405128464609979 92 5499307
SGTC_538 2922-0838 53.3 µM 1.74177764761761 0.105383571652331 no 519 0.0407736797077167 76 777039
SGTC_2027 5150920 200 µM 1.7382867945126 0.105857608664376 no 520 0.0410801460263951 54 786715
SGTC_2143 5623677 140.463 µM 1.73737368001561 0.105981858063231 no 521 0.0411606169442586 60 5375313
SGTC_2532 xanthone 78.9 µM 1.73631406030957 0.106126174794176 no 522 0.0412541592312483 51 7020 An insecticide.
SGTC_572 0960-0087 17.7 µM 1.73142539290564 0.106793833800148 no 523 0.0416879604383587 101 6796365
SGTC_761 k216-0224 480 µM 1.73092654063731 0.106862133494277 no 524 0.0417324336209893 79 1340404
SGTC_1402 3909-7673 35.9 µM 1.72567822145882 0.107582610740084 no 525 0.0422026591059938 54 5328014
SGTC_2428 5615643 7.78 µM 1.72277338720365 0.107982881326558 no 526 0.0424647565768998 97 2253075
SGTC_2134 5324836 1.464 µM 1.72113113104358 0.108209649372013 no 527 0.0426135156709515 50 699272
SGTC_1427 4048-4900 550 nM 1.71679615569609 0.10880988289246 no 528 0.0430082118082355 74 24132586
SGTC_1965 Pectolinarigenin 58.4 µM 1.71472498165964 0.109097507406433 no 529 0.0431978305706055 60 5320438 An anti-inflammatory.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.70421489441378 0.110565468404401 no 530 0.044170473800491 67 6857784
SGTC_2688 kanamycin b 96.69 µM 1.69767732008596 0.111485694622087 no 531 0.0447843403056245 117 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2083 5306046 65.942 µM 1.69766691293821 0.11148716388424 no 532 0.0447853229667165 64 539837
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.69753399856882 0.111505929711292 no 533 0.0447978745008046 65 279621
SGTC_657 3534-0529 86.7 µM 1.69595608783959 0.11172888345767 no 534 0.0449470982300932 73 1049549
SGTC_203 k066-0004 30.888 µM 1.69448321298375 0.111937283554104 no 535 0.0450867494822506 93 6795412
SGTC_1821 st053465 65.6 µM 1.68989263100022 0.112588597236058 no 536 0.0455242488279286 57 675086
SGTC_3019 9081971 49.47 µM 1.68953025877709 0.112640125785105 no 537 0.0455589291007155 74 16451803
SGTC_1229 0139-0193 12.2 µM 1.68936885610176 0.112663082318287 no 538 0.045574382730244 104 3090752
SGTC_4 0960-0234 25.671 µM 1.68720792310409 0.112970756772181 no 539 0.045781689221928 64 6821112
SGTC_3296 9122258 64.045 µM 1.68286817775044 0.113590461885056 no 540 0.0462003065672171 64 4730474
SGTC_1839 st053978 48 µM 1.68269170699576 0.113615712661658 no 541 0.0462173939863366 62 3788398
SGTC_1308 1187-1617 41.4 µM 1.68135600870995 0.113806964302496 no 542 0.0463468924436198 86 2882570
SGTC_679 0422-0091 41.4 µM 1.67794800849812 0.11429597724035 no 543 0.0466786245926473 93 627384 YHR062C RPP1
SGTC_3207 9114163 49.47 µM 1.67426565512194 0.11482603673447 no 544 0.0470392005968223 101 849233
SGTC_3059 1327-0034 3 µM 1.67096110906268 0.115303199225611 no 545 0.0473646799130127 84 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2053 5265679 138 µM 1.66945493104282 0.11552115192594 no 546 0.0475136275521931 87 764595
SGTC_1287 0971-0001 34.6 µM 1.66926878743073 0.115548108297209 no 547 0.0475320615274741 89 4665869
SGTC_3097 9117246 49.47 µM 1.66748683508339 0.115806387759246 no 548 0.0477088200123847 70 16423892
SGTC_2 0422-0095 29 µM 1.66409221451736 0.116299544199857 no 549 0.0480470013385823 69 6790840
SGTC_2729 fluphenazine 10.66 µM 1.66289517655859 0.116473799782185 no 550 0.048166710045738 83 3372 An atypical antipsychotic.
SGTC_1178 0988-0033 191 µM 1.65964688536827 0.116947593936974 no 551 0.0484927551964132 72 5392207
SGTC_1387 3342-1166 1.8 µM 1.65275824937286 0.117956882879138 no 552 0.0491900371243444 55 3418228
SGTC_1957 st077035 62.4 µM 1.64922036275568 0.118477624900875 no 553 0.0495512488736381 72 705593
SGTC_3241 9133421 49.47 µM 1.64793010081239 0.118667942474628 no 554 0.0496835078538957 58 17018221
SGTC_2467 5474540 200 µM 1.63906174979299 0.119981896697374 no 555 0.050600200062543 86 5413519
SGTC_2831 7999036 19.48 µM 1.63883642903123 0.120015413772054 no 556 0.0506236650498038 81 2988270
SGTC_1994 st072947 40.9 µM 1.63855815079532 0.120056817522189 no 557 0.050652657009219 75 5286565 YDL195W SEC31
SGTC_535 2293-4129 48.2 µM 1.63651424156338 0.120361229978246 no 558 0.0508660037868523 99 396118 YIL048W NEO1
SGTC_677 0929-0063 136 µM 1.63447630754142 0.120665293412363 no 559 0.0510794385441256 62 1539583
SGTC_1143 3454-2408 5.08 µM 1.63252213378315 0.120957367176766 no 560 0.051284769815611 72 X1143
SGTC_1255 0566-0045 221 µM 1.62996489203388 0.121340327307674 no 561 0.0515544586246268 92 2788469
SGTC_2809 7964133 12.99 µM 1.62925954390567 0.121446106671742 no 562 0.0516290432946523 90 1253665
SGTC_453 enantio-paf c16 10 µM 1.62872793940842 0.121525872951195 no 563 0.051685312700122 120 13871343 A lipid and platelet activating factor
SGTC_1600 coumarin 106 71.1 µM 1.62855796130154 0.121551385622604 no 564 0.0517033148679341 77 100336 A hepatotoxic, DNA x-linker.
SGTC_1321 1326-2144 215 µM 1.62131414022344 0.122642139230834 no 565 0.0524751419887529 87 3513030
SGTC_1747 st037496 66.6 µM 1.62071700707599 0.122732359179875 no 566 0.0525391722537425 110 723305
SGTC_329 k048-0121 21.3 µM 1.6195944406425 0.122902092045072 no 567 0.0526597123044491 81 6832902
SGTC_2376 9072922 81.32 µM 1.61916630670402 0.122966869545883 no 568 0.0527057426639924 76 17087968
SGTC_3257 9139206 32.98 µM 1.61088200029052 0.124225015992476 no 569 0.0536027219489176 81 4910041
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.60794755640035 0.124672825379864 no 570 0.0539233325519323 72 61125 An anti-inflammatory.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.60706199836372 0.124808186885823 no 571 0.054020384240661 105 4114 Related to psoralen; DNA damaging agent.
SGTC_2473 5854593 8.94 µM 1.60623376936312 0.124934878299665 no 572 0.0541112781038781 83 2872951
SGTC_1519 esterone 74 µM 1.60554020642434 0.125041039394164 no 573 0.054187486144752 84 698 A steroid.
SGTC_1934 st074720 32.6 µM 1.60468296504549 0.125172341183443 no 574 0.0542817963540946 98 17250992
SGTC_3243 9134147 49.47 µM 1.60182533089109 0.12561073406327 no 575 0.0545971199538693 71 24282180
SGTC_2192 5915882 198.485 µM 1.60091786715766 0.125750172952317 no 576 0.0546975558448801 85 2876149
SGTC_248 streptozotocin 5.23457 mM 1.59664565792513 0.126408081875776 no 577 0.0551723576407842 101 5300 DNA alkylating agent.
SGTC_2121 5257820 149.641 µM 1.59488463692681 0.126679971261832 no 578 0.0553690178663368 64 791256
SGTC_2082 5219693 150 µM 1.59370223749821 0.126862753867155 no 579 0.0555013714283078 78 2834649
SGTC_3198 9112019 49.47 µM 1.59244352045649 0.127057535792358 no 580 0.0556425420483139 91 45595555
SGTC_1126 isoteolin 1.0172 µM 1.58917513151174 0.127564278706507 no 581 0.0560104296485293 84 133323
SGTC_3009 9080819 71.4286 µM 1.58902677911893 0.127587313092468 no 582 0.0560271734984376 86 17027216
SGTC_1302 1159-0335 255 µM 1.58869796425559 0.127638377840787 no 583 0.0560642993866801 80 649284
SGTC_1414 3917-0015 5.4 µM 1.58608860908291 0.128044112872028 no 584 0.0563596052323331 64 6618702
SGTC_3228 9131799 49.47 µM 1.58583350959169 0.128083826940589 no 585 0.0563885410114403 92 17015818
SGTC_2342 7990637 118.86 µM 1.58482387383074 0.128241091688028 no 586 0.0565031782749286 104 2033102 YER133W GLC7
SGTC_1911 st060208 74.3 µM 1.58307372797917 0.12851401870391 no 587 0.0567023304367125 93 688783
SGTC_1086 cerivastatin 2.18 µM 1.58259056944035 0.128589435966526 no 588 0.0567574071782541 76 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2227 7312221 64.1025 µM 1.58138255281398 0.12877813227727 no 589 0.0568952971361244 78 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2876 9059903 25.97 µM 1.57917773582315 0.129123027266221 no 590 0.0571476476098112 92 6916095
SGTC_1044 1222-0021 1.78 µM 1.57776368442367 0.129344561196693 no 591 0.0573099548195635 113 4306703
SGTC_2223 6903751 107.57 µM 1.57547581773455 0.129703549962416 no 592 0.0575733279982039 76 5598863
SGTC_2426 5582046 32.21 µM 1.57106507898279 0.130397584325293 no 593 0.0580837665096095 82 2251934
SGTC_2806 7952793 58.44 µM 1.56991966642575 0.130578235572232 no 594 0.0582169008322877 89 2972490
SGTC_3278 9139605 49.47 µM 1.5688834820465 0.130741808680651 no 595 0.0583375457010075 91 7958859
SGTC_1678 st019265 80.2 µM 1.56735698451378 0.130983041059826 no 596 0.0585156362763858 78 5367020
SGTC_1722 st034304 3.6505 µM 1.56619053325377 0.131167582499701 no 597 0.0586520091498859 102 4036148 YLR033W RSC58
SGTC_511 blebbistatin 171 µM 1.56315801941184 0.13164818926264 no 598 0.0590077158202403 78 3476986 A myosin inhibitor.
SGTC_3193 9111931 49.47 µM 1.5554555954545 0.132874363499311 no 599 0.0599188010993855 92 17087244
SGTC_600 1495-0418 41.6 µM 1.5528380402947 0.13329284534371 no 600 0.0602309161029609 107 5377768
SGTC_1008 4106-0037 6 µM 1.5517158700288 0.133472529823743 no 601 0.0603651118448846 105 2905394
SGTC_47 0149-0135 24.25 µM 1.54779995899339 0.13410085917736 no 602 0.0608352331939047 98 5239155
SGTC_1265 0819-1001 68.8 µM 1.54506820695934 0.134540385147778 no 603 0.0611648830885622 95 3106768
SGTC_975 1335-0046 28.5 µM 1.54489008878032 0.134569077820977 no 604 0.0611864256039406 77 16486740
SGTC_576 1073-0113 22.7 µM 1.54436627473256 0.134653482233422 no 605 0.0612498126882616 137 5439563
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.54385519159836 0.134735870271127 no 606 0.0613117086395301 137 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1343 1487-0095 224 µM 1.5381100684492 0.135664380312253 no 607 0.0620108523043552 95 4560101 YGL055W OLE1
SGTC_1683 st010134 710 nM 1.53729624552057 0.135796261578476 no 608 0.0621103902380712 85 3818134
SGTC_399 oxolinic acid 75 µM 1.53383107456457 0.13635878054085 no 609 0.0625356080420197 89 4628 A DNA gyrase inhibitor.
SGTC_719 2810-4230 27.3 µM 1.53280276619833 0.13652601740501 no 610 0.0626622294386751 67 721079
SGTC_752 1896-0090 130 µM 1.52871727065345 0.137191839222889 no 611 0.0631672744680176 95 772567
SGTC_2911 7942208 15.64 µM 1.52753830491169 0.137384389456614 no 612 0.063313604873968 68 1243384
SGTC_2434 5670830 169.91 µM 1.52629704737809 0.137587312596644 no 613 0.0634679518319395 94 1549830
SGTC_2908 7930301 100 µM 1.52603361138614 0.137630405917476 no 614 0.0635007470130751 94 2223178
SGTC_2486 5283202 22.39 µM 1.52430085295611 0.137914083140496 no 615 0.0637167870994542 83 1377751
SGTC_2081 5214970 32.255 µM 1.522870255081 0.138148592775164 no 616 0.0638955844133413 77 2063512
SGTC_42 0133-0086 60.653 µM 1.52068654255555 0.138507080158345 no 617 0.0641692587046203 133 162923 Model of phenazepam hydroxylation.
SGTC_1915 st067105 30.6 µM 1.51139626362965 0.140039292312269 no 618 0.06534376037201 120 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_292 k038-0015 474 µM 1.50894589221478 0.140445335373037 no 619 0.065656305333263 91 46368540
SGTC_3055 9094636 49.47 µM 1.50342323594662 0.141363405314375 no 620 0.0663649692146641 120 25236176
SGTC_1174 0739-0097 51.1 µM 1.50161674251757 0.141664592311469 no 621 0.0665980584563968 101 728447
SGTC_1892 st058411 7.36 µM 1.49520296460404 0.14273743676641 no 622 0.0674307400353311 87 3934738
SGTC_1225 1216-0074 20.6 µM 1.49203173445928 0.143269918397982 no 623 0.067845413110478 85 4241466
SGTC_2777 climbazole 1.536 µM 1.49022297885133 0.143574226814093 no 624 0.0680828081566829 114 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2534 helenine 20.12 µM 1.48411417586046 0.144605206318721 no 625 0.0688893165343566 109 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2441 5730946 39.09 µM 1.48298679862851 0.144796016967131 no 626 0.069038959119719 97 1774275
SGTC_1073 triclabendazole 3.09 µM 1.48259566822526 0.144862256098288 no 627 0.0690909343658879 93 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_559 1550-0661 158 µM 1.48247269514023 0.144883086181924 no 628 0.0691072818364247 88 5830875
SGTC_1735 st034310 56.75 µM 1.47920168554614 0.14543789407654 no 629 0.0695432096075429 112 871153
SGTC_1040 k898-0338 155 µM 1.47721162422673 0.145776133903034 no 630 0.0698094593996201 92 20969351
SGTC_716 1683-5115 658 µM 1.47494391142858 0.1461622086961 no 631 0.0701138117129093 106 723597
SGTC_3113 9123498 49.47 µM 1.47456342565396 0.14622705306406 no 632 0.0701649769875882 106 8897275
SGTC_2770 toltrazuril 17.5 µM 1.46464697450791 0.147923880483622 no 633 0.0715086294262348 84 68591 Kills coccidiodes.
SGTC_633 0437-0093 97.7 µM 1.46258888645919 0.148277689917061 no 634 0.0717899530363914 98 2831118
SGTC_342 k048-0088 23.3 µM 1.4621267734844 0.148357210312307 no 635 0.0718532366015217 113 6820570
SGTC_166 k072-0058 166.424 µM 1.45949154384763 0.148811225665069 no 636 0.072214933188098 115 5846229
SGTC_492 tmb-8 126 µM 1.45939766105963 0.148827417543875 no 637 0.0722278446993869 75 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2689 tacrolimus 100 µM 1.45582854726897 0.149443852563164 no 638 0.0727200110099892 102 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3035 9091303 49.47 µM 1.45577339971279 0.149453390654973 no 639 0.0727276357304606 93 25237002
SGTC_2680 butyl paraben 22.24 µM 1.45577050830976 0.149453890751218 no 640 0.0727280355137471 114 7184 An antifungal and steroid mimetic.
SGTC_2917 7979103 53.79 µM 1.4527550863698 0.149976045302464 no 641 0.0731458831224663 94 2980565
SGTC_273 hydroxyurea 18.1 mM 1.45200278978384 0.150106503368953 no 642 0.0732504147671485 123 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2397 5161689 200 µM 1.44351398352652 0.151583815485024 no 643 0.0744378681138405 96 2259942
SGTC_1260 0700-1617 7.75 µM 1.43587299664216 0.152921819152174 no 644 0.0755192418079136 108 2853078
SGTC_647 0140-0236 81 µM 1.43439533970265 0.153181470670816 no 645 0.0757297384047925 96 990837
SGTC_294 k038-0071 157 µM 1.43409842768012 0.153233678808283 no 646 0.0757720882719137 119 24152826
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.43269042779381 0.153481417887829 no 647 0.0759731631199724 96 16486 A toxic proline analog.
SGTC_35 0133-0054 64.071 µM 1.43155974303826 0.153680555021701 no 648 0.0761349288373048 124 99677
SGTC_3273 9137859 49.47 µM 1.43089801571094 0.153797178301914 no 649 0.0762297229222449 121 2377234
SGTC_2177 5811945 192 µM 1.42633301481468 0.154603312876257 no 650 0.0768861195454474 104 5343475
SGTC_1316 1272-0050 65.9 µM 1.42471327108076 0.154890013788986 no 651 0.0771200506602543 103 7340392
SGTC_1946 st076057 65.1 µM 1.41387234290499 0.156817935761515 no 652 0.0786996938867969 75 953009
SGTC_2657 nystatin 74.44 µM 1.41241873227053 0.157077637528751 no 653 0.0789133520206666 103 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.41228926809029 0.157100781282544 no 654 0.0789324025292593 102 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_784 4579-0127 173 µM 1.41009624176285 0.157493159886479 no 655 0.0792556334275619 112 1948547
SGTC_956 1185-0240 191 µM 1.40923485546612 0.157647456053455 no 656 0.0793828671949024 97 1416193
SGTC_815 1582-0027 36.9 µM 1.40897529635827 0.157693969147718 no 657 0.0794212364835448 111 3128206
SGTC_2818 7996756 12.99 µM 1.40867697182375 0.157747440155907 no 658 0.0794653536014545 107 2241621
SGTC_3022 9087993 49.47 µM 1.40707729413894 0.158034365852794 no 659 0.0797022350980372 101 17173644
SGTC_427 1354-0053 47.3 µM 1.40534727179929 0.158345056157299 no 660 0.0799590189522407 86 6813657
SGTC_2779 methotrexate 400 µM 1.39924107020379 0.159444854531927 no 661 0.0808703522466563 121 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3206 9114350 49.47 µM 1.39755972130206 0.159748561118681 no 662 0.0811226604612249 94 17087243
SGTC_1717 st033143 58.0435 µM 1.39416981573015 0.160362038978959 no 663 0.0816331652611808 101 674616
SGTC_2481 5478948 45.16 µM 1.3863483212737 0.161783376322022 no 664 0.0828202842441787 107 77792
SGTC_2303 7774051 200 µM 1.38400399431169 0.162210986198342 no 665 0.083178615843578 115 2953184
SGTC_3090 9117696 49.47 µM 1.38124454794284 0.162715256679424 no 666 0.0836018908774666 91 7923821
SGTC_2798 7813637 45.45 µM 1.36995595753628 0.164788777084437 no 667 0.0853503251636843 150 956368
SGTC_2583 asiatic acid 100 µM 1.36798135546098 0.165153228801749 no 668 0.0856589561035605 147 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1693 xanthone 101.9 µM 1.36781953594201 0.165183118895082 no 669 0.0856842855418182 132 7020 An insecticide.
SGTC_2106 5357045 167.29 µM 1.36542580732616 0.165625679521167 no 670 0.0860596286002261 113 668842
SGTC_2117 5521686 200 µM 1.36441976979558 0.165811907775186 no 671 0.0862177446175648 110 803312
SGTC_1841 st054148 70 µM 1.36306324296459 0.166063229554188 no 672 0.0864312899192595 119 675442
SGTC_928 2764-0428 58.7 µM 1.36201989032667 0.166256697362029 no 673 0.0865958040129912 140 662578
SGTC_1751 st044839 27.194 µM 1.35763919657101 0.167070592927728 no 674 0.0872890995264747 106 5291326
SGTC_1003 4049-0218 100 µM 1.35641677100268 0.167298166895459 no 675 0.0874833000748269 133 295161
SGTC_3323 9138564 53.9225 µM 1.35639069039294 0.167303024391645 no 676 0.0874874468793484 118 43912313 YNL103W MET4
SGTC_2571 chrysanthemic acid 100 µM 1.35618571050123 0.167341204924555 no 677 0.0875200436919953 118 2743 An insecticide.
SGTC_650 1328-0195 38 µM 1.35571883973899 0.167428187459112 no 678 0.0875943213842043 115 2780821
SGTC_1531 st059297 52.4 µM 1.35544908988076 0.167478457740864 no 679 0.0876372591862754 120 7566702
SGTC_1484 3473-2379 286 µM 1.35518026758137 0.167528564837179 no 680 0.0876800649643141 91 671917
SGTC_3099 9120367 49.47 µM 1.35376785120366 0.167791990650049 no 681 0.0879052266634756 119 24824940
SGTC_3136 9095672 49.47 µM 1.35321139525299 0.167895846882525 no 682 0.0879940529309181 122 17217380
SGTC_1845 st056753 3.01 µM 1.35015202532406 0.168467582786111 no 683 0.0884836116120546 104 5375839
SGTC_2331 7980721 200 µM 1.34885964135385 0.168709479533995 no 684 0.0886910267656251 133 2981221
SGTC_3162 9099653 49.47 µM 1.34703779453911 0.169050855282503 no 685 0.088984030309952 90 25237511
SGTC_760 0568-0725 82.9 µM 1.34635413481641 0.169179073118532 no 686 0.0890941675014814 118 3916171
SGTC_1191 1487-1166 10.6 µM 1.3458132090027 0.169280565975923 no 687 0.089181382209983 93 3955771
SGTC_381 3461-2219 42.7 µM 1.34565307564881 0.169310618981891 no 688 0.0892072130609735 116 2883159
SGTC_1167 k781-0610 148 µM 1.34460891190119 0.169506666241815 no 689 0.0893757819344394 133 4525169
SGTC_1317 1273-0028 910 nM 1.34381014809621 0.169656736657042 no 690 0.0895048935344516 132 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1984 st072354 53.1 µM 1.34026872592135 0.170323119337284 no 691 0.0900789975719705 112 5762938
SGTC_1437 4092-1038 11.6 µM 1.33923774473338 0.170517431792358 no 692 0.0902466442023671 132 3977136
SGTC_1703 st026983 48.3 µM 1.33691618206622 0.170955503905957 no 693 0.0906249990348819 95 1104023
SGTC_675 1309-0189 238 µM 1.33538241193843 0.171245316480285 no 694 0.0908756090963139 111 4246530
SGTC_2945 9067681 61.76 µM 1.33441082543036 0.171429064425725 no 695 0.0910346270825792 146 16456930
SGTC_3102 9121669 49.47 µM 1.33430939918174 0.171448253576505 no 696 0.0910512392421635 134 41905072
SGTC_807 1315-0151 48 µM 1.32973405378825 0.172315305057297 no 697 0.0918029553022258 158 4011080
SGTC_3315 9136395 68.55 µM 1.32926513599202 0.172404325167183 no 698 0.0918802561069499 157 16876844
SGTC_2156 5649887 115 µM 1.32548915924427 0.173122231572445 no 699 0.0925044813332176 131 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_797 k781-0471 270 µM 1.32138932869018 0.173903863334377 no 700 0.0931857911866997 128 23738129
SGTC_3312 9133330 71.43 µM 1.32090612701201 0.173996133230636 no 701 0.0932663332790644 127 17617324
SGTC_2557 derrustone 83.84 µM 1.31892388455782 0.174374978506558 no 702 0.0935972801370219 127 629853 An antioxidant.
SGTC_353 1988-1175 58.3 µM 1.31814237684767 0.17452448382471 no 703 0.0937279954392576 129 2788357
SGTC_854 0422-0053 192 µM 1.31759731610131 0.17462880413791 no 704 0.0938192422699264 133 3596728
SGTC_115 0527-0192 112.043 µM 1.31465897834034 0.175191860578495 no 705 0.0943122694937522 170 4233931
SGTC_1975 st070967 30.8 µM 1.31348649065678 0.175416858554886 no 706 0.0945095350709549 157 261391
SGTC_314 1671-0008 2.74 µM 1.31338520824783 0.175436303032647 no 707 0.0945265896263208 142 3913060
SGTC_3186 9110464 49.47 µM 1.30794923194913 0.176481920956931 no 708 0.0954452646909733 99 17018021
SGTC_1992 st073643 23.3 µM 1.30624678311663 0.176810198396848 no 709 0.0957343240133968 134 3161292
SGTC_2882 9058044 58.44 µM 1.30571394859806 0.176913022329487 no 710 0.0958249263516618 127 18076804
SGTC_1009 4106-0057 9.87 µM 1.30470043913773 0.177108708961094 no 711 0.0959974359517497 150 2928005
SGTC_1153 4055-0057 267 µM 1.3020288980618 0.177625180371678 no 712 0.0964532535436859 146 882706
SGTC_1640 st009078 66.4 µM 1.29773734594297 0.178456825193118 no 713 0.0971888029241196 134 690618
SGTC_1527 coumarin 137 µM 1.2976307104275 0.178477520898147 no 714 0.0972071319546486 136 323 A hepatotoxic, DNA x-linker.
SGTC_1258 0671-0043 57.1 µM 1.2900981861834 0.179943248977289 no 715 0.0985082847871478 143 4298767
SGTC_1375 2910-0797 186 µM 1.28772690559997 0.180406228348056 no 716 0.0989205221327421 111 742508
SGTC_3158 9100007 49.47 µM 1.28740840260945 0.180468471171527 no 717 0.0989759885699036 106 19297233
SGTC_421 streptovitacin 30 mM 1.28561441865314 0.18081930855338 no 718 0.099288831063772 126 91467 include heat shock
SGTC_1812 st052057 4.327 µM 1.28538227079859 0.180864739369697 no 719 0.0993293667587688 127 3645418
SGTC_725 1497-0963 19 µM 1.28267311406124 0.181395444093557 no 720 0.099803311533614 112 3549977
SGTC_1765 st044815 90.4 µM 1.28029055671011 0.181862975159789 no 721 0.100221483804341 147 645695
SGTC_621 3584-0052 32.1 µM 1.27983966365297 0.181951538992358 no 722 0.100300765582338 133 2273927
SGTC_1919 st067113 52.3 µM 1.27806665796924 0.182300051956378 no 723 0.100612961979568 140 1268243
SGTC_3324 9138759 60.749 µM 1.27730880672675 0.182449147057 no 724 0.100746622830386 108 45595710
SGTC_2785 7756463 72.73 µM 1.27611804892199 0.182683563413638 no 725 0.100956896129672 171 2201551
SGTC_2676 harmalol 100 µM 1.27352033567751 0.183195609739634 no 726 0.101416730551297 120 5459187 A monoamine oxidase inhibitor
SGTC_613 3914-0030 117 µM 1.27133656087222 0.183626754738486 no 727 0.101804470442856 88 1145395
SGTC_3037 9091026 49.47 µM 1.27037013831557 0.183817758236388 no 728 0.101976407513317 129 25236398 YIL048W NEO1
SGTC_1431 4049-0260 9.09 µM 1.26920363075013 0.184048471251937 no 729 0.102184223230619 144 3854841
SGTC_48 0382-0018 55 µM 1.26814768333697 0.184257472959081 no 730 0.102372607940028 95 762596
SGTC_1156 4092-0367 4.88 µM 1.26804559600285 0.18427768674196 no 731 0.102390834057423 153 1357585
SGTC_1842 st055362 61.2 µM 1.26543122703171 0.184795814443997 no 732 0.102858393538802 120 676032
SGTC_1339 1486-1321 22.7 µM 1.26360596914073 0.185158088720884 no 733 0.10318574502457 132 3469382
SGTC_1720 st037298 9.481 µM 1.25482372423183 0.186907334953409 no 734 0.104771379128767 143 597396
SGTC_2665 lovastatin 100 µM 1.25413076261662 0.187045792856904 no 735 0.10489724030322 134 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1412 3909-8563 178 µM 1.25292487342047 0.187286888008699 no 736 0.105116524370914 147 23767530
SGTC_1788 fluconazole 20 µM 1.24913902800305 0.188045045183354 no 737 0.105807114046061 136 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_324 1315-0088 19.6 µM 1.2488777290479 0.188097442970058 no 738 0.105854899232172 134 6787421
SGTC_1925 st057770 10.1 µM 1.24779848830526 0.188313956540104 no 739 0.106052431219803 127 5989122
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.24349356720654 0.18917912382826 no 740 0.106843004986178 120 6312947
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.24337932674957 0.189202116213975 no 741 0.106864042345383 147 688803
SGTC_2782 7736369 71.43 µM 1.24213234258252 0.189453199963869 no 742 0.107093868625235 148 2950836 YOL077C BRX1
SGTC_118 0083-0097 135.343 µM 1.24198850448209 0.189482175352435 no 743 0.107120401719231 188 5207356
SGTC_2951 9072950 58.06 µM 1.24015922444056 0.189850911515532 no 744 0.107458253446358 134 16488155
SGTC_3221 9128209 49.47 µM 1.23976683729262 0.189930064182064 no 745 0.107530823785456 127 16460723
SGTC_3163 9099914 49.47 µM 1.23687288871024 0.1905144603 no 746 0.108067138290132 151 16268368
SGTC_800 3448-7362 155 µM 1.23591982248854 0.190707161313871 no 747 0.108244183991948 183 15991913
SGTC_3135 9127742 49.47 µM 1.23523967276745 0.190844754299927 no 748 0.10837065913264 127 3643468
SGTC_2346 9031566 143.75 µM 1.23260285480788 0.191378753063497 no 749 0.108861985657271 124 4771086
SGTC_1590 st077108 57.8 µM 1.22956128763975 0.191995856193432 no 750 0.109430717081982 120 5489485
SGTC_1615 st002656 86.5 µM 1.22889820102972 0.192130551251077 no 751 0.109554988025362 126 1584458
SGTC_715 0868-0130 184 µM 1.21653079185593 0.194653369048375 no 752 0.111891394307138 112 2876258
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.2148483024588 0.194998129505102 no 753 0.112211977157131 130 364106
SGTC_333 3486-0131 40.1 µM 1.21345489250777 0.195283935284344 no 754 0.112477975127467 131 6744690
SGTC_957 1187-1561 14.1 µM 1.21289147428983 0.195399571623064 no 755 0.112585657842256 140 1538454
SGTC_3252 9135871 49.47 µM 1.2117865976676 0.195626457980124 no 756 0.112797039958952 132 17682838
SGTC_3286 9117135 37.221 µM 1.21097807575701 0.195792589217767 no 757 0.112951903705475 133 3438150
SGTC_3196 9111891 49.47 µM 1.20942310695932 0.19611233741179 no 758 0.113250167865401 141 18891510
SGTC_1085 doxorubicin 7.67 µM 1.20363651789844 0.197305012993213 no 759 0.114365049250078 163 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1868 st057644 42.7 µM 1.20319208343133 0.197396796581625 no 760 0.1144509988515 133 688665
SGTC_3048 9093155 49.47 µM 1.20297866822172 0.197440879777004 no 761 0.114492287758406 124 25236002
SGTC_3160 9100216 49.47 µM 1.19966292657945 0.198126546176853 no 762 0.115135138417906 127 17191039
SGTC_1594 piperine 70.1 µM 1.19177285391649 0.199763915016931 no 763 0.116675161322262 133 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2544 sphondin 68.51 µM 1.18889780440942 0.200362570649861 no 764 0.117239942118941 163 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_941 3237-0776 460 µM 1.18732731884593 0.200690038830663 no 765 0.117549268171292 127 760008
SGTC_148 3253-0744 288.01 µM 1.18630324807497 0.200903744845767 no 766 0.117751282199506 131 6893655
SGTC_226 1,3-diallylurea 8.28947 mM 1.1860485787466 0.200956911161605 no 767 0.117801557844821 131 74537 YKL182W FAS1
SGTC_2897 9048598 12.99 µM 1.185191004879 0.201136005551519 no 768 0.117970967817684 114 6467404
SGTC_1480 1070-0044 41.2 µM 1.18486864454177 0.20120335152696 no 769 0.118034693241784 142 3124987
SGTC_2856 9022925 19.48 µM 1.18241657287843 0.201716069019308 no 770 0.118520225232463 132 4944862
SGTC_256 clotrimazole 625 nM 1.17904459672269 0.202422411026993 no 771 0.119190209040122 137 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3352 9151559 45.5865 µM 1.17828468121493 0.202581797690365 no 772 0.119341566385046 128 17159339
SGTC_1348 1493-0373 93.8 µM 1.17805125016834 0.202630773184806 no 773 0.119388087594217 152 3010129
SGTC_3218 9131285 49.47 µM 1.17781117257267 0.20268115055346 no 774 0.119435946761567 157 17156417
SGTC_1873 rapamycin 2 nM 1.17500313076048 0.203270939601576 no 775 0.119996731631042 135 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.17351881668681 0.203583111928934 no 776 0.120293907800362 134 5379071
SGTC_313 3474-0040 5.03 µM 1.171592894948 0.203988586501952 no 777 0.120680271002294 164 1043375 YIL048W NEO1
SGTC_80 0159-0065 512.242 µM 1.17116267715247 0.20407922825364 no 778 0.12076669713505 112 1548079
SGTC_2232 chlorophetanol 41.5365 µM 1.17073050133557 0.204170306689546 no 779 0.120853560468294 145 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2452 5863136 48.41 µM 1.16063004744882 0.206305802973163 no 780 0.122896190284163 136 2184096
SGTC_2702 st077768 96.8 µM 1.15996730652893 0.206446384752282 no 781 0.123031058632841 131 6484119
SGTC_204 PMA1.184 62.41 µM 1.15833763606979 0.206792314623969 no 782 0.123363139123079 156 2252213 YGL008C PMA1
SGTC_654 1124-0271 80.9 µM 1.15779569436019 0.206907428487179 no 783 0.123473710440493 156 5403748
SGTC_2961 9083290 32.55 µM 1.15320083204177 0.207884946338418 no 784 0.124413981048329 144 17741490
SGTC_251 melphalan 456.522 µM 1.15264378850051 0.20800363767471 no 785 0.124528311156787 172 460612 A DNA alkylator.
SGTC_688 0527-0193 473 µM 1.14865769156293 0.208854136856807 no 786 0.125348579011097 168 4007154
SGTC_2869 9037858 32.47 µM 1.1478050247661 0.209036332967614 no 787 0.125524531269055 146 27187042
SGTC_849 0386-0493 241 µM 1.14711351688844 0.209184161683006 no 788 0.125667354058506 158 726119
SGTC_2139 5578692 56.4705 µM 1.14622540758595 0.209374109582405 no 789 0.125850948806693 164 650991 YMR113W FOL3
SGTC_3028 9087778 49.47 µM 1.14516188275008 0.209601708672301 no 790 0.126071052441902 155 17217395
SGTC_2884 9058502 51.95 µM 1.14315124675217 0.210032391181503 no 791 0.126487900074013 141 6471554
SGTC_1441 4106-0040 13 µM 1.14113628618786 0.210464521221511 no 792 0.126906606587681 148 2904180
SGTC_1787 fluconazole 80 µM 1.13552888089551 0.211669833307697 no 793 0.128076894054494 149 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2558 carylophyllene oxide 100 µM 1.13077042944809 0.212695824500722 no 794 0.129075864538205 156 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1084 voriconazole 435 nM 1.13028933014633 0.212799717877872 no 795 0.129177164523114 171 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1942 st076330 65.2 µM 1.12949685759131 0.212970916870408 no 796 0.129344147211806 156 24208414
SGTC_1960 st011366 51.8 µM 1.12771886469781 0.213355311548173 no 797 0.129719334024794 170 3972846
SGTC_3064 1327-0027 10 µM 1.12517184542852 0.213906670664032 no 798 0.13025811062328 124 16000455 YPR107C YTH1
SGTC_57 miconazole 162.5 nM 1.12367627290858 0.214230806882296 no 799 0.130575192849201 171 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_949 1165-0505 146 µM 1.12327330489975 0.214318191194253 no 800 0.130660718885196 147 6244267
SGTC_973 1325-0077 65.9 µM 1.1216331240554 0.214674081116419 no 801 0.131009230888464 152 2835149
SGTC_93 0109-0045 59.227 µM 1.12016493474041 0.214992943072276 no 802 0.131321741784161 158 88733
SGTC_1234 0326-0494 15.5 µM 1.11294046514818 0.216565957478275 no 803 0.1328669997365 182 1547813
SGTC_682 0kpi-0099 17 µM 1.11260705347822 0.216638712990044 no 804 0.132938614892014 196 1714895 YML126C ERG13
SGTC_1456 k015-0012 13 µM 1.11154458782033 0.216870653491394 no 805 0.133167004445923 188 2989616
SGTC_917 harmaline 728.087 nM 1.10919907087115 0.217383197189539 no 806 0.133672156673443 157 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3355 9151058 44.0485 µM 1.10767109827843 0.21771746651533 no 807 0.134001942803472 153 17015728
SGTC_488 nitrendipine 139 µM 1.1043496868457 0.218445102326136 no 808 0.134720738506634 145 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_692 k241-0027 77.8 µM 1.10242782846162 0.21886677092174 no 809 0.135137859374285 153 3600480
SGTC_2437 5741531 144.16 µM 1.10199734893165 0.218961285166257 no 810 0.135231412077329 183 2262990
SGTC_227 fluconazole 33.516 µM 1.09393472153696 0.220735813613709 no 811 0.13699180458359 212 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2903 5923464 63.88 µM 1.09252994403385 0.221045835788669 no 812 0.137300118115075 159 2876576
SGTC_2240 6690706 185.951 µM 1.09098674848206 0.221386692670633 no 813 0.137639356792097 142 805876
SGTC_625 k213-0058 121 µM 1.08812083135311 0.222020505427211 no 814 0.138270884295295 192 3655420
SGTC_2580 diallyl disulphide 81.36 µM 1.08423422679946 0.22288170145128 no 815 0.139130479819287 168 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2560 caryophyllene 100 µM 1.07917553834823 0.22400545380763 no 816 0.140254741090319 176 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_502 l-744,832 89.3 µM 1.07869137083183 0.224113176770674 no 817 0.140362666865476 157 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1877 wortmannin 25 µM 1.0780706725106 0.224251319651312 no 818 0.140501109192045 167 312145 A covalent inhibitor of PI 3-kinase.
SGTC_382 3229-0966 23.2 µM 1.07743381916443 0.224393108238671 no 819 0.140643251101524 163 5722370
SGTC_2008 4012253 172 µM 1.07733952157243 0.224414106913194 no 820 0.140664306060262 163 603940
SGTC_1461 k072-0203 53.8 µM 1.0736964039602 0.225226228562561 no 821 0.141479386812055 150 5418714
SGTC_3306 9127676 59.7925 µM 1.07138177372548 0.225743068175596 no 822 0.141998902329342 150 41905287
SGTC_1328 1441-0025 69.2 µM 1.07121129030094 0.225781162357959 no 823 0.142037218093658 155 4562601
SGTC_379 3970-0972 5.9 µM 1.07112555427302 0.225800321276985 no 824 0.142056489716704 163 2898042 YBL034C STU1
SGTC_310 1273-0058 1.06 µM 1.07074591725108 0.225885167548438 no 825 0.142141845259014 142 2734232
SGTC_455 paf C-16 10 µM 1.07018254213759 0.226011111245256 no 826 0.142268575446392 155 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_544 k015-0020 52.4 µM 1.0700754079977 0.226035065799884 no 827 0.142292683721533 176 3008304
SGTC_2895 9054447 58.44 µM 1.06748077213321 0.226615648991821 no 828 0.142877395867286 173 2697450
SGTC_669 0108-0021 26.2 µM 1.06479452845075 0.227217616446781 no 829 0.143484460861215 173 17201
SGTC_2526 patulin 37.61 µM 1.06408058892241 0.227377756500977 no 830 0.143646096729069 182 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2654 protoveratrine a 100 µM 1.06288193698554 0.227646762806699 no 831 0.143917747712898 186 5702278 A heart drug and vasodilator.
SGTC_3220 9131269 49.47 µM 1.06270015182051 0.227687575408481 no 832 0.143958976001729 166 17722206
SGTC_1107 amlodipine 47 µM 1.06019978181028 0.228249351448464 no 833 0.144526860180756 152 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2651 TUB2.036 5 µM 1.05823903662961 0.228690430636313 no 834 0.14497323923215 181 15992207 YFL037W TUB2
SGTC_1310 1188-0297 994 nM 1.0545262453133 0.229526950861947 no 835 0.145821025566971 166 1588352
SGTC_867 0518-0118 155 µM 1.0524280821765 0.230000440219458 no 836 0.146301595117384 188 6848158
SGTC_212 3807-4682 38.772 µM 1.05194228651512 0.230110146887266 no 837 0.146413014658091 178 3125501 YBL034C STU1
SGTC_2870 9038528 12.99 µM 1.0509879353069 0.230325752136033 no 838 0.146632065482445 167 6463316
SGTC_282 k297-0036 65.7 µM 1.04983371238185 0.230586662891077 no 839 0.14689728626676 180 5061378
SGTC_337 1315-0038 354 µM 1.04766072240765 0.231078312623587 no 840 0.147397474998102 151 1626437
SGTC_1627 st003713 25.6 µM 1.04338915519896 0.232046479094132 no 841 0.148384047094138 171 16195070 YER133W GLC7
SGTC_1564 D-Arginine 115 µM 1.04199498270773 0.232362961571397 no 842 0.148707002554638 193 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2649 anisomycin 9.56 µM 1.03841438698999 0.233176869637714 no 843 0.149538587193959 174 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_319 1348-1596 45.5 µM 1.03069396461451 0.234937177988412 no 844 0.151342177953922 184 5380505
SGTC_2423 st077119 87.2 µM 1.03029848182152 0.235027548020042 no 845 0.15143495576565 164 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1299 1079-1439 3.74 µM 1.0293910701777 0.235234969221681 no 846 0.15164797182029 181 323161
SGTC_1335 1486-0900 202 µM 1.02803542760546 0.235545037755078 no 847 0.151966581519743 158 X1335
SGTC_1766 st045414 44.774 µM 1.02718922746903 0.235738698620297 no 848 0.152165684826631 172 253960
SGTC_1834 st055981 52.8 µM 1.0268283979841 0.235821304538355 no 849 0.152250637423942 175 471719 YDL150W RPC53
SGTC_386 1509-0011 3.07 µM 1.02592547522223 0.23602808362298 no 850 0.152463356770555 166 3107280
SGTC_32 0928-0142 34.1 µM 1.0247099758992 0.236306603825303 no 851 0.152750027274855 181 2244242
SGTC_1573 oleylamine 1.06 µM 1.02393831278817 0.236483517016049 no 852 0.152932206245988 186 5356789 An amine of the fatty acid oleic acid.
SGTC_418 lividomycin a 100 µM 1.02368842581706 0.236540822276233 no 853 0.152991231964708 161 72394 An antibiotic.
SGTC_2715 st079500 56.4 µM 1.0217378952214 0.236988389669514 no 854 0.153452485142388 187 28246688
SGTC_2586 curcumin 80 µM 1.02017645354671 0.237347012174501 no 855 0.153822391364241 178 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_510 ag-490 170 µM 1.0197746392571 0.237439346642924 no 856 0.153917676747723 168 5328779
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.01954863988702 0.237491288580754 no 857 0.153971286915602 185 165521
SGTC_561 1550-0330 72.9 µM 1.01802663864975 0.23784125589908 no 858 0.154332648362306 179 6812934
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.01596746074574 0.2383151908588 no 859 0.154822440983621 159 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2145 5634607 200 µM 1.01595741245653 0.238317504814073 no 860 0.154824833567785 161 308662
SGTC_1352 1496-0991 99 µM 1.0151131959437 0.238511957895091 no 861 0.155025936018685 193 3000039
SGTC_1914 st062367 72.6 µM 1.01499314692731 0.238539616504267 no 862 0.155054547129309 184 978205
SGTC_1816 st051957 91.6 µM 1.01465048114423 0.238618574404843 no 863 0.155136233354767 174 674121
SGTC_2407 paclitaxel 400 µM 1.01096004794995 0.239469839059472 no 864 0.156017775980381 178 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3292 9120825 59.784 µM 1.01011447658943 0.239665118513164 no 865 0.156220223613932 185 24824900
SGTC_3242 9133940 49.47 µM 1.00868010866486 0.239996575538384 no 866 0.156564037190437 157 17248444
SGTC_2060 5238662 140 µM 1.00765458303966 0.240233709507589 no 867 0.156810157710297 175 790130
SGTC_2421 5690543 90.72 µM 1.00641984147505 0.240519390150508 no 868 0.15710682653906 194 3397993
SGTC_1211 1056-0033 32.3 µM 1.00234243200353 0.241464088079395 no 869 0.158089117807014 193 6741922
SGTC_1936 st074407 74.3 µM 1.00233412866077 0.241466013940927 no 870 0.158091122274891 202 809813
SGTC_306 1672-3436 11.6 µM 0.997447299285414 0.242600901927126 no 871 0.159273721146599 186 6797378
SGTC_1487 3970-0795 2.82 µM 0.994428375130721 0.243303439483813 no 872 0.160007179767419 182 3765103
SGTC_1228 0124-0032 52.5 µM 0.993378566789609 0.243547999091021 no 873 0.16026275129086 167 X1228
SGTC_2385 9074692 200 µM 0.993177512528269 0.243594851118981 no 874 0.160311727549506 169 17046906
SGTC_2846 9008642 19.48 µM 0.991418562448896 0.244004949836778 no 875 0.160740619975161 197 2992898
SGTC_2516 gossypol 71.55 µM 0.986333834613178 0.245192544278881 no 876 0.161984660885689 186 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2311 7694451 200 µM 0.983739773052705 0.24579961120494 no 877 0.1626217393351 217 2163142
SGTC_2972 9093619 59.92 µM 0.981694108679786 0.246278909672092 no 878 0.163125284323917 151 25236256
SGTC_1272 0839-0021 27 µM 0.981482434217384 0.246328533516804 no 879 0.163177446270647 201 5027250
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.980384826445882 0.246585936826209 no 880 0.163448098418397 181 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1430 4049-0248 69.1 µM 0.979797852942369 0.246723648858253 no 881 0.163592956081879 204 22774488
SGTC_1106 tegaserod maleate 11.7 µM 0.979416557726246 0.246813128003689 no 882 0.163687099585154 209 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2780 5215298 71.43 µM 0.978817267781251 0.246953799415679 no 883 0.163835138034242 206 2834131
SGTC_2905 7799065 20.05 µM 0.974703349092829 0.247920617183107 no 884 0.164853715600124 180 1296806
SGTC_2218 6965428 192.983 µM 0.972215412021231 0.24850628951772 no 885 0.165471697415003 175 675684
SGTC_2040 5100729 123 µM 0.970456058946274 0.248920894242211 no 886 0.165909608704036 180 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_459 nigericin 15.3 µM 0.964789410188578 0.250258781054781 no 887 0.167325150564867 194 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_326 k292-0812 17.5 µM 0.964662408008981 0.250288809692743 no 888 0.16735696492217 185 3579357
SGTC_2378 9074213 121.43 µM 0.964631171381601 0.250296195633302 no 889 0.167364790371155 207 657714
SGTC_2364 9055074 200 µM 0.962320827400148 0.250842799631406 no 890 0.167944235025472 171 6470630
SGTC_934 2950-0684 338 µM 0.962185949026127 0.250874730000547 no 891 0.167978102974622 200 1121253
SGTC_792 4534-1957 155 µM 0.961937484136109 0.250933555852438 no 892 0.168040503995861 176 1717904
SGTC_2820 7989630 71.43 µM 0.95954282821538 0.251500881912497 no 893 0.168642677404722 147 2984098
SGTC_211 3455-0679 143.504 µM 0.957846355751539 0.251903208739137 no 894 0.169070120064275 159 748649
SGTC_2267 7931562 200 µM 0.956908851726186 0.252125688096525 no 895 0.169306631503887 169 934880
SGTC_110 0850-0284 111.64 µM 0.956793996933067 0.252152951446369 no 896 0.169335621412907 165 3906265
SGTC_3050 9093513 49.47 µM 0.955286409285606 0.252510955147812 no 897 0.169716439230423 217 25236664
SGTC_821 1114-0266 29.2 µM 0.954940870140292 0.25259304732038 no 898 0.16980380000437 192 3123235
SGTC_2974 9094440 9.66 µM 0.954690183888131 0.25265261342056 no 899 0.1698671976856 175 25236134
SGTC_250 brefeldin a 552.239 µM 0.954430091876191 0.252714422262677 no 900 0.169932990090105 177 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2504 purpurogallin 52.29 µM 0.951903899032085 0.253315166343428 no 901 0.170572860982599 181 5281571 An antioxidant.
SGTC_2097 5376186 200 µM 0.95129137432706 0.253460941461504 no 902 0.170728242222702 192 742755
SGTC_2002 4023503 131 µM 0.948851182245896 0.254042121565571 no 903 0.171348153125597 221 4736863 YCR052W RSC6
SGTC_79 0052-0007 94.094 µM 0.947837373308929 0.254283785664514 no 904 0.171606125568613 193 2801472
SGTC_3141 9094609 49.47 µM 0.945398506372497 0.254865637638916 no 905 0.172227732232259 227 25236309 YDL196W YDL196W
SGTC_1933 st074711 15.9 µM 0.944193738912784 0.255153321614885 no 906 0.172535327068868 221 17250958
SGTC_3184 9108758 49.47 µM 0.943534024020113 0.25531092552147 no 907 0.172703910322117 196 902885
SGTC_603 3794-0023 45.9 µM 0.943513333276307 0.255315869300921 no 908 0.172709199323438 201 3802260
SGTC_439 amiodarone 34.4 µM 0.943358821198779 0.255352789499406 no 909 0.17274869921457 191 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2488 5268135 45.7 µM 0.937052624692337 0.256862014031626 no 910 0.17436574451658 202 1270356 YLR208W SEC13
SGTC_2023 5144124 124 µM 0.934281012491484 0.257526792939898 no 911 0.175079478043492 194 2830192
SGTC_2704 st078022 71.1 µM 0.933174229350446 0.257792507421269 no 912 0.175365009110938 186 54697681
SGTC_2043 5101342 149 µM 0.93316052355965 0.257795798774292 no 913 0.175368546819504 205 678451
SGTC_2234 tolnaftate 200 µM 0.930522437250643 0.258429723240539 no 914 0.176050326261458 196 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1673 st016611 27.3 µM 0.930189666812438 0.258509744327837 no 915 0.176136445527667 224 5226799
SGTC_521 r062-0005 13.8 µM 0.929885532534051 0.258582890519398 no 916 0.176215177222725 181 2832033
SGTC_1147 3809-1045 12.3 µM 0.929189385539243 0.258750358547332 no 917 0.176395473657767 182 325925
SGTC_1175 0741-0056 27.6 µM 0.92850904549634 0.258914078209496 no 918 0.176571788939837 204 765927
SGTC_882 0843-0131 351 µM 0.926492795795649 0.259399590899351 no 919 0.177094969657695 226 5425421
SGTC_3003 9075612 71.4286 µM 0.925903317543319 0.259541625993373 no 920 0.177248113537781 224 6501993
SGTC_2796 7949634 45.45 µM 0.925316708244009 0.25968300966788 no 921 0.177400595075728 200 2971588
SGTC_407 eburnamonine 100 µM 0.924341998929116 0.259918020488242 no 922 0.177654141282692 192 3195
SGTC_3138 9097216 49.47 µM 0.923428231663648 0.260138437241957 no 923 0.177892042495348 224 25237486
SGTC_1131 3454-3128 32.3 µM 0.922495692080519 0.260363481509317 no 924 0.1781350381762 188 710982
SGTC_1732 st034308 51.822 µM 0.920876406976169 0.260754492144073 no 925 0.178557478799613 192 830119
SGTC_2985 9022375 71.43 µM 0.920853380142467 0.260760054638143 no 926 0.178563490608058 210 4939335
SGTC_1497 4476-2978 41.3 µM 0.920712919373768 0.260793986469399 no 927 0.178600164638444 192 1528379
SGTC_355 1311-2252 105 µM 0.91982624331767 0.261008237790524 no 928 0.178831783483934 197 5338538
SGTC_594 1487-1584 10.8 µM 0.917174184729916 0.261649605750994 no 929 0.179525686040587 204 5013332
SGTC_1421 4029-0249 71.4 µM 0.916206293003753 0.261883879825396 no 930 0.17977935273826 218 2894095
SGTC_2414 st077232 92.9 µM 0.916175157765801 0.261891417762752 no 931 0.179787516450322 176 729801
SGTC_3320 9137005 35.139 µM 0.915426597732606 0.262072679949705 no 932 0.179983860258223 211 4908713
SGTC_146 3448-8650 53.125 µM 0.915345352435879 0.262092357189491 no 933 0.180005178617901 225 2891488 YIL048W NEO1
SGTC_2026 5148700 152 µM 0.914326596715062 0.262339159431947 no 934 0.180272629601221 206 79838
SGTC_512 prima-1 270 µM 0.913035037026271 0.262652221767361 no 935 0.180612057301825 180 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2253 7938677 135.83 µM 0.910314984594468 0.263312162398958 no 936 0.18132820912468 183 2301972
SGTC_1962 st076595 64.5 µM 0.909356174927613 0.263544991016102 no 937 0.181581073594771 208 279619
SGTC_2833 9001315 45.46 µM 0.908601345692005 0.263728360763244 no 938 0.181780297992256 196 2989378
SGTC_2080 5212524 12.4 µM 0.908340992883226 0.26379162304365 no 939 0.181849045411778 219 260183
SGTC_2752 diclazuril 33.15 µM 0.90714956941058 0.264081221848415 no 940 0.182163853992983 197 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_380 3970-0968 6 µM 0.906888517747349 0.264144697194312 no 941 0.182232876871664 211 2891601
SGTC_2315 7733312 200 µM 0.905512968631496 0.264479293623279 no 942 0.182596846289286 193 726316
SGTC_68 0986-0284 82.829 µM 0.904263342147311 0.2647834467729 no 943 0.182927889906619 202 423278 YIL048W NEO1
SGTC_2666 tannic acid 100 µM 0.903197331602933 0.265043049160498 no 944 0.183210586918139 226 16134267 A thiamine antagonist.
SGTC_550 4123-0385 25.7 µM 0.901200031198522 0.265529793652194 no 945 0.183740987192138 199 5731123
SGTC_2594 a-mangostin 100 µM 0.8989497696421 0.266078727792053 no 946 0.18433970821368 213 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3076 9116187 49.47 µM 0.898702409002108 0.266139104574796 no 947 0.184405596761786 196 27241210
SGTC_2932 9016711 44.54 µM 0.898554582271108 0.266175190030918 no 948 0.184444979820087 207 7117328
SGTC_1463 k081-0032 34.1 µM 0.89851609952306 0.266184584323661 no 949 0.184455233007512 197 977755
SGTC_1137 ixabepilone 100 µM 0.898360707434081 0.266222519880521 no 950 0.184496638652063 199 154225 A novel microtubule stabilizer.
SGTC_90 0870-0863 4.608 µM 0.89789184092704 0.26633699989887 no 951 0.184621607458492 235 1738164
SGTC_2374 9071832 200 µM 0.897133689752946 0.266522165325245 no 952 0.184823791763823 200 17381698
SGTC_1259 0671-0132 43 µM 0.89688814975039 0.266582148215969 no 953 0.184889302041955 207 X1259
SGTC_2413 inermin 26.06 µM 0.896165634425047 0.266758690847611 no 954 0.185082153425672 243 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2359 9039622 200 µM 0.895161488861362 0.267004146360243 no 955 0.185350384043335 229 6463596
SGTC_2293 7624732 200 µM 0.891383476563947 0.267928672581119 no 956 0.186361739539532 199 894453
SGTC_644 1498-1197 63.3 µM 0.891034152199443 0.268014237915954 no 957 0.186455424324154 208 6741615
SGTC_235 0330-0087 5 mM 0.890213406073596 0.268215329880883 no 958 0.186675653770128 203 46494818 YHR062C RPP1
SGTC_2786 7743617 45.45 µM 0.8900714778938 0.268250111567183 no 959 0.186713753448358 193 583674
SGTC_2977 9011197 71.43 µM 0.890019190210981 0.268262926041119 no 960 0.186727790943186 225 2704722
SGTC_562 3772-2733 112 µM 0.889650220867824 0.268353360450636 no 961 0.186826865446293 202 2876874 YIL048W NEO1
SGTC_2773 thioridazine 9.09 µM 0.889164447740123 0.268472446853075 no 962 0.18695735334093 219 5452 An antipsychotic.
SGTC_1871 st057448 67.3 µM 0.888031897983446 0.268750192518831 no 963 0.187261796649417 226 691747
SGTC_2989 9073649 71.4286 µM 0.887244455428696 0.268943389380936 no 964 0.187473651445662 230 21367202
SGTC_3036 9090181 49.47 µM 0.886861885917634 0.269037276917005 no 965 0.187576631998882 218 25236586
SGTC_40 0327-0103 19.753 µM 0.884980128390411 0.269499324022844 no 966 0.188083674532911 196 409036
SGTC_2212 7123476 200 µM 0.88439829347859 0.269642268331863 no 967 0.188240621932474 194 1085715
SGTC_105 0111-0055 734.78 µM 0.8818834112787 0.270260557297924 no 968 0.188919929345351 185 5179370
SGTC_295 k015-0027 31 µM 0.880539913874641 0.270591149157479 no 969 0.189283446303645 193 3887424
SGTC_1884 5633444 25 µM 0.880445535608375 0.270614380229565 no 970 0.189308998890645 227 5724239
SGTC_776 4476-4378 112 µM 0.87972187220224 0.270792542013954 no 971 0.189504998795651 226 2892008
SGTC_1065 prochlorperazine maleate 2.48 µM 0.878896387859654 0.270995842993513 no 972 0.189728728687272 237 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2294 7971431 200 µM 0.875895604609923 0.271735519322083 no 973 0.190543394619537 223 5741572
SGTC_518 1021-0119 62.6 µM 0.874695321774901 0.272031663446343 no 974 0.190869853135108 227 1097762
SGTC_1038 k292-0204 154 µM 0.873862747708283 0.272237177524367 no 975 0.191096501946132 205 4454212
SGTC_3268 9137683 49.47 µM 0.87380479960287 0.272251484410284 no 976 0.191112283102772 274 1953228
SGTC_1818 st052136 56.3 µM 0.873202227500366 0.272400276388187 no 977 0.191276430469101 222 674169
SGTC_1268 0828-0275 2.46 µM 0.872701884347522 0.272523855852553 no 978 0.191412795179027 218 745337
SGTC_288 1315-0019 35.1 µM 0.872667553425619 0.272532336247393 no 979 0.191422153993455 239 6811474
SGTC_2769 toremifene 3.73 µM 0.8710504695364 0.272931935289824 no 980 0.19186329832772 231 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1018 4259-0013 28.1 µM 0.869931790011565 0.273208543097813 no 981 0.192168840656177 217 6801262
SGTC_3223 9129970 49.47 µM 0.869896133685575 0.273217361863538 no 982 0.192178584277957 226 17248386
SGTC_1020 4335-0961 93.3 µM 0.867069943869205 0.27391680265634 no 983 0.192951843795156 230 669075
SGTC_2845 9003024 42.97 µM 0.865956937868701 0.274192498153202 no 984 0.193256888526159 213 2990173
SGTC_489 paxilline 115 µM 0.865727719408823 0.274249293385584 no 985 0.193319747613936 228 105008 A toxic potassium channel blocker.
SGTC_2133 5320837 200 µM 0.864558220388126 0.274539159615767 no 986 0.193640656109497 188 2841355
SGTC_872 0588-0139 234 µM 0.862042498773713 0.275163205742046 no 987 0.194332065846076 187 2047100
SGTC_819 1013-0258 27.7 µM 0.860232829968506 0.27561254098262 no 988 0.194830355488875 218 5753198
SGTC_331 k048-0133 24.5 µM 0.859291702847548 0.27584636249076 no 989 0.19508980032478 217 6813582
SGTC_3142 9086498 49.47 µM 0.855712457139491 0.27673650945869 no 990 0.196078424028883 230 25236367
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.853025405964505 0.277405694047587 no 991 0.196822607722055 217 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1734 st037168 69.4 µM 0.852288541907421 0.277589341166539 no 992 0.19702698198265 207 708907
SGTC_1057 3448-5381 134 µM 0.851976378371498 0.277667158953939 no 993 0.197113601382304 211 5497911
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.849743700577963 0.27822404321065 no 994 0.197733798248906 201 803109
SGTC_378 3970-0959 8.33 µM 0.848724992837257 0.278478314551827 no 995 0.198017167876246 228 6615653
SGTC_507 nimesulide 162 µM 0.845829646965395 0.279201615807047 no 996 0.198823892031558 211 4495 A COX2 inhibitor.
SGTC_3235 9132602 49.47 µM 0.845379853146541 0.279314063010016 no 997 0.198949394705566 228 4912240
SGTC_1163 k060-0048 49.9 µM 0.84512706000872 0.279377270248236 no 998 0.19901995067449 212 6809982
SGTC_3001 9076041 71.4286 µM 0.84511022888295 0.279381478872529 no 999 0.199024648870474 217 16004211
SGTC_2746 daunorubicin 9.88 µM 0.844235523248645 0.279600241463958 no 1000 0.199268903864162 192 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1396 3511-0007 98.6 µM 0.842179867099692 0.280114685137836 no 1001 0.199843640652839 223 X1396
SGTC_1777 st045864 34.765 µM 0.840996092829312 0.280411141692683 no 1002 0.200175061640406 269 4691462
SGTC_1233 0325-0408 14.2 µM 0.839916327802484 0.280681683266049 no 1003 0.200477651067487 224 12874
SGTC_2352 9027995 87.8 µM 0.839527960100338 0.280779021976792 no 1004 0.200586552959345 208 2997347
SGTC_3192 9110362 49.47 µM 0.839204020049871 0.280860225318846 no 1005 0.200677415907052 232 16649480
SGTC_1651 st011928 86.1 µM 0.838401181696669 0.281061524927735 no 1006 0.200902713000668 210 720198
SGTC_1 0258-0098 57.368 µM 0.838394041550618 0.281063315524341 no 1007 0.200904717389958 211 6790032 YDR047W HEM12
SGTC_2098 5376439 882.5 nM 0.837690116847503 0.281239871901533 no 1008 0.201102382768178 222 2844116
SGTC_2826 7992541 19.48 µM 0.837647124810794 0.281250656775946 no 1009 0.201114458913109 280 2985066
SGTC_3183 9108214 49.47 µM 0.834075611174849 0.282147294335664 no 1010 0.202119188750626 192 4974831
SGTC_2812 7970281 58.44 µM 0.833369557358057 0.282324713713285 no 1011 0.202318169135032 222 2233435
SGTC_728 3030-5151 22.5 µM 0.83332084674318 0.282336955845635 no 1012 0.202331901100005 228 3125388
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.833287473466756 0.282345343488641 no 1013 0.202341309651675 216 94937 An inhibitor of serotonin biosynthesis.
SGTC_3191 9110352 49.47 µM 0.831981803043249 0.282673589241579 no 1014 0.202709607929315 221 17122424
SGTC_285 1486-1325 46 µM 0.831078922192078 0.282900680833265 no 1015 0.202964523063152 232 22310230
SGTC_835 0312-0010 67.2 µM 0.828504186875555 0.28354875611114 no 1016 0.203692512389803 248 1626196
SGTC_2817 7995342 71.43 µM 0.827746230867441 0.283739673323535 no 1017 0.203907115672234 221 18879975
SGTC_2268 7933382 153.85 µM 0.825897616271492 0.284205568283584 no 1018 0.204431086465946 218 935025 YOR257W CDC31
SGTC_955 1216-0110 33 µM 0.824596885399223 0.284533602551067 no 1019 0.204800245126752 218 3619719
SGTC_1659 st012954 42.1 µM 0.82363203484462 0.284777047159108 no 1020 0.205074333985636 228 24207262
SGTC_470 aa-861 153 µM 0.823616345720714 0.284781006554573 no 1021 0.205078792656864 232 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2673 kobusone 100 µM 0.821734588863879 0.285256087714444 no 1022 0.205613984396556 268 6710676 An epoxy ketone and protein crosslinker.
SGTC_1648 st011736 69.8 µM 0.821137741053238 0.285406850819649 no 1023 0.205783907318306 231 2855514
SGTC_869 0564-0080 44.1 µM 0.819909101076654 0.285717323334717 no 1024 0.206133964049512 201 6843321
SGTC_2487 5918373 44.05 µM 0.818566814833673 0.286056697352792 no 1025 0.206516803463577 248 2876279
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.816074165509312 0.286687428547429 no 1026 0.207228859348602 232 688662
SGTC_1128 3448-9350 235 µM 0.813582144076549 0.287318659270176 no 1027 0.207942185249088 216 619386
SGTC_1217 1183-1422 255 µM 0.811294067723377 0.287898809009774 no 1028 0.208598407991563 237 2849664
SGTC_3046 9092212 49.47 µM 0.810483786766354 0.288104391124183 no 1029 0.208831089843765 247 25236637
SGTC_3117 9124945 49.47 µM 0.809648145080025 0.288316480220317 no 1030 0.209071214439747 208 17592065
SGTC_2351 9026858 72.31 µM 0.808793668759721 0.288533425719325 no 1031 0.209316919287231 247 1409300
SGTC_2734 clemastine 41.6 µM 0.806676223190742 0.28907136140002 no 1032 0.209926523095348 265 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2987 9018338 71.43 µM 0.806094096279865 0.289219332988825 no 1033 0.210094297698859 251 5055682
SGTC_3281 9140613 49.47 µM 0.805831526797764 0.289286087513721 no 1034 0.210169998533023 216 16013766
SGTC_2956 9076196 2.52 µM 0.805596367189544 0.289345879617442 no 1035 0.210237810484258 264 16423868
SGTC_3233 9132340 49.47 µM 0.802261380825054 0.290194463701084 no 1036 0.211200888436087 270 17682950
SGTC_2071 5230951 39.92 µM 0.800247462378994 0.290707467327409 no 1037 0.211783717918849 258 1799272
SGTC_1313 1220-0047 237 µM 0.799841579522938 0.290810908831701 no 1038 0.211901294565478 237 3528706
SGTC_1624 st003710 6.25 µM 0.79791016764619 0.291303375506834 no 1039 0.212461311283375 239 24207033
SGTC_162 k030-0015 37.8 µM 0.792750894341489 0.292620779237607 no 1040 0.213961485835843 256 1809920 YMR134W ERG29
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.788946361148667 0.293594024072018 no 1041 0.215071678715974 236 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_413 propylparaben 100 µM 0.78647468968004 0.294227109039136 no 1042 0.215794720738543 235 7175 A pharmaceutical preservative.
SGTC_1195 1502-0147 41.1 µM 0.783579087189455 0.294969579285306 no 1043 0.216643565403743 226 817940
SGTC_3172 9105863 49.47 µM 0.782009158032274 0.295372490161014 no 1044 0.21710459575668 247 2348785
SGTC_770 0389-1121 67.2 µM 0.781647475227521 0.295465349291658 no 1045 0.217210888955689 221 6753108
SGTC_1782 st039423 80.636 µM 0.78159134980217 0.29547976024339 no 1046 0.217227386077639 233 2068169
SGTC_207 4185-0010 4.486 µM 0.778583458804769 0.296252548802166 no 1047 0.218112563043899 241 3761753
SGTC_2485 5633444 17.78 µM 0.775949971763506 0.29692990545013 no 1048 0.218889262672496 244 5724239
SGTC_2686 alizarin 95.37 µM 0.773727406191602 0.297502120145455 no 1049 0.219546004745328 230 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1249 0481-0015 10.2 µM 0.773061256771265 0.297673722883178 no 1050 0.219743064314304 269 4227577
SGTC_1794 st048918 76.9 µM 0.771930581910367 0.297965092564077 no 1051 0.220077771617495 206 672303
SGTC_403 arphamenine a 50 µM 0.770924848417453 0.298224374626735 no 1052 0.220375738839699 255 5487158 An arginine aminopeptidase inhibitor.
SGTC_1662 st014054 52 µM 0.770239925889133 0.298401009148814 no 1053 0.220578792155847 250 2838777
SGTC_343 4130-2827 29.8 µM 0.767806708429625 0.299028895744994 no 1054 0.221301014215018 236 1118244
SGTC_1243 0416-0003 5.65 µM 0.765529952542065 0.299616950462039 no 1055 0.221978018813732 249 2141977
SGTC_575 k072-0246 11.9 µM 0.76279871510489 0.300323081980425 no 1056 0.222791723764626 243 6796779
SGTC_137 0438-0332 85.389 µM 0.762735407596797 0.300339458358379 no 1057 0.222810604811446 265 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_396 dithiazanine 1.25 µM 0.761868867253835 0.300563655454522 no 1058 0.22306913638966 231 10578 An antihelmenthic.
SGTC_970 1315-0089 19.5 µM 0.761808107250739 0.300579378522443 no 1059 0.22308727049168 241 6811083 YLR033W RSC58
SGTC_812 4251-0442 148 µM 0.761748575184912 0.300594784193132 no 1060 0.223105038924308 261 5723007
SGTC_219 mitoxanthrone 164.414 µM 0.760368175457048 0.300952103088837 no 1061 0.223517270349032 256 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1190 1486-1332 13 µM 0.757096258350884 0.301799808533923 no 1062 0.224496097775948 254 4150046
SGTC_929 2805-0021 398 µM 0.754073726374964 0.302583854250775 no 1063 0.225402476398876 266 3098024
SGTC_1565 sinapyl alcohol 95.1 µM 0.751163154003706 0.303339719195199 no 1064 0.226277235982892 255 5280507 A phenol propionate derived from cinnamic acid.
SGTC_321 4534-3890 65.3 µM 0.750387750877328 0.303541230799054 no 1065 0.226510603053222 251 699746
SGTC_1063 disulfiram 1.84 µM 0.747145395208534 0.304384500347375 no 1066 0.227487900433499 275 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_385 1494-0393 12.4 µM 0.746817790492653 0.304469761529213 no 1067 0.227586777612314 254 3090647
SGTC_627 1391-0720 175 µM 0.746695901880608 0.304501486517515 no 1068 0.227623572031625 285 997839
SGTC_215 1287-0124 461.5 µM 0.746537237806397 0.30454278557234 no 1069 0.227671472847712 250 5560863
SGTC_1349 flufenamic acid 69 µM 0.746193640759241 0.304632229817643 no 1070 0.227775224530266 261 3371 A non-steroidal anti-inflammatory.
SGTC_271 rotenone 740 µM 0.744434283876588 0.305090403751945 no 1071 0.228306892178057 261 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_405 ebelactone b 50 µM 0.743182944487228 0.305416465200955 no 1072 0.228685463912735 256 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1196 1588-0294 184 µM 0.742352873548936 0.305632841961456 no 1073 0.228936782281175 247 6144269
SGTC_356 1634-0012 32.5 µM 0.742237947153374 0.305662805477579 no 1074 0.228971590450617 268 735457
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.741272260457246 0.305914629917365 no 1075 0.229264188722584 218 4000243
SGTC_3002 9075603 71.4286 µM 0.741018057855525 0.305980934204902 no 1076 0.229341245690067 263 20105405
SGTC_2341 7987486 176.74 µM 0.73988962410662 0.306275343079716 no 1077 0.229683485395569 241 1258686
SGTC_2627 acetyl isogambogic acid 100 µM 0.739178532107407 0.306460931588515 no 1078 0.229899297457751 260 6857789 A caspase activator and apoptosis inducer.
SGTC_2186 6124449 200 µM 0.737530011766146 0.30689137124595 no 1079 0.230400049624498 254 3834182 YLR033W RSC58
SGTC_1901 st060216 58.6 µM 0.737425278622654 0.306918726772923 no 1080 0.230431883801226 248 688792
SGTC_1237 0330-0133 46.1 µM 0.736773380090999 0.307089022042665 no 1081 0.230630086982295 276 X1237 YHR072W ERG7
SGTC_2991 9074669 71.4286 µM 0.736182485766201 0.307243417162906 no 1082 0.230809824721006 266 17333109
SGTC_1428 4049-0204 61.7 µM 0.735969600648588 0.307299050413618 no 1083 0.23087459910144 270 X1428
SGTC_1815 st051655 58.2 µM 0.735883723892096 0.307321493834857 no 1084 0.230900731624815 264 5984156
SGTC_962 1254-0300 21.5 µM 0.735632119607256 0.30738725339419 no 1085 0.230977304979099 229 7340576
SGTC_977 1348-1378 135 µM 0.725587187298699 0.310017647627808 no 1086 0.234045939046255 262 X977
SGTC_1830 st055982 50.3 µM 0.723891657521153 0.310462609564792 no 1087 0.234566126023637 277 455313 An antimicrobial agent.
SGTC_1469 k284-2957 126 µM 0.722931226202957 0.310714781017787 no 1088 0.23486106894913 249 23884841
SGTC_1646 st011709 75.6 µM 0.721941813319997 0.310974654907926 no 1089 0.235165126168238 264 5757843
SGTC_1297 1068-0111 14.1 µM 0.720723868753016 0.311294683177541 no 1090 0.235539711952094 262 767057
SGTC_2165 5727197 32.143 µM 0.718981819827756 0.311752673558566 no 1091 0.236076060695327 264 1361712
SGTC_1952 st077036 64.1 µM 0.718341620749316 0.311921057233529 no 1092 0.236273336606359 260 2937007
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.714825938386114 0.312846443864085 no 1093 0.237358302655111 254 6708514
SGTC_1904 st060225 78 µM 0.714430499953266 0.312950603869462 no 1094 0.237480508860216 246 66595
SGTC_931 2812-0076 566 µM 0.714231416225239 0.313003048941585 no 1095 0.237542046719728 277 3450959
SGTC_97 0535-0701 19.132 µM 0.710153108067252 0.314078238276329 no 1096 0.238804597939439 253 2832013 YGL099W LSG1
SGTC_1047 2043-3044 82 µM 0.709930503025665 0.314136970559977 no 1097 0.238873616873262 304 669592
SGTC_247 mechlorethamine 29.705 µM 0.709034996548561 0.31437328921578 no 1098 0.23915137981393 246 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_684 1140-0066 328 µM 0.707630817296161 0.314743996674674 no 1099 0.239587275046163 271 6813534
SGTC_1103 duloxetine 36.1 µM 0.705972745683483 0.315181972950291 no 1100 0.240102543254137 262 60835 A selective serotonin reuptake inhibitor.
SGTC_795 0685-0265 78 µM 0.702671730171594 0.316054702942384 no 1101 0.241130174592646 254 302754
SGTC_1998 st075797 76.8 µM 0.701518826334908 0.316359752292014 no 1102 0.241489644930003 269 24208315
SGTC_2298 7976326 193.81 µM 0.698833635833297 0.317070717063748 no 1103 0.242328002656882 245 2235818
SGTC_2549 cedrol 20.94 µM 0.698495669619948 0.3171602491807 no 1104 0.242433632532664 266 6708665 A sedative which affects the nervous system.
SGTC_490 phenamil 164 µM 0.69795564841861 0.31730333078676 no 1105 0.242602465577396 267 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1862 st057513 3.81 µM 0.694372429345036 0.318253415446722 no 1106 0.243724339671857 283 5393163
SGTC_2271 7849410 118.62 µM 0.693998978250062 0.318352504367811 no 1107 0.243841424842825 286 972430
SGTC_744 1594-0068 283 µM 0.692335189455253 0.318794120399606 no 1108 0.244363428080827 283 668392
SGTC_1438 4092-1045 4 µM 0.692292176231946 0.318805540727141 no 1109 0.24437693118957 287 1351342
SGTC_357 1325-0123 420 µM 0.691009476583444 0.319146185963447 no 1110 0.244779792852349 285 1098503
SGTC_449 xestospongin c 11.1929 µM 0.686692685151903 0.320293712691418 no 1111 0.246138203744755 283 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1688 st021091 57.6 µM 0.685635287828572 0.320575061945294 no 1112 0.246471561664355 288 3656366
SGTC_830 4076-0286 57.8 µM 0.684451761377909 0.320890093586111 no 1113 0.246844970128549 275 6866659
SGTC_1669 st015249 58.4 µM 0.683865894328504 0.321046087708936 no 1114 0.247029926079546 284 722793
SGTC_2569 tetrandrine 100 µM 0.683716215149914 0.321085946651156 no 1115 0.247077191102863 256 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1207 2099-0101 141 µM 0.683690701336526 0.32109274107912 no 1116 0.247085248223603 270 5837381
SGTC_1079 idarubicin 2.36 µM 0.683180827943458 0.321228534907663 no 1117 0.247246292878291 298 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_64 000l-0018 272.079 µM 0.682919735121998 0.321298080629508 no 1118 0.247328781354693 270 6811119
SGTC_2687 chenodiol 100 µM 0.680493461503899 0.321944651930176 no 1119 0.2480960302558 256 5702181 A cholesterol synthesis inhibitor.
SGTC_443 clozapine 122 µM 0.679672723215437 0.322163490521907 no 1120 0.248355855490928 285 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2357 9067248 200 µM 0.679540213367568 0.322198828236448 no 1121 0.248397818393536 290 9150235
SGTC_1358 1509-0022 2.48 µM 0.677135046784209 0.322840516917708 no 1122 0.249160137171548 288 3258434
SGTC_25 0118-0223 35.662 µM 0.676229262835902 0.323082313320321 no 1123 0.249447548068598 283 5333628
SGTC_1799 st045822 46.1415 µM 0.675990726364561 0.323146002384258 no 1124 0.249523266478122 274 3674992
SGTC_1417 3966-0327 90.4 µM 0.675912440102701 0.323166905889196 no 1125 0.249548119474594 283 651118
SGTC_1363 1636-0063 10.4 µM 0.672969934880973 0.323952999548726 no 1126 0.250483209142469 278 6072185
SGTC_1885 st057546 99.9 µM 0.671924633696763 0.324232442298459 no 1127 0.250815838591329 266 702008
SGTC_2681 menadione 3.18 µM 0.671293719046953 0.32440115409019 no 1128 0.251016717565146 290 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1066 ketoconazole 628 nM 0.6682806602972 0.325207367604255 no 1129 0.251977228009666 296 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2836 9010338 19.48 µM 0.667710451081436 0.3253600325245 no 1130 0.252159218742405 264 2994051
SGTC_2750 bromebric acid 70.15 µM 0.666344571608298 0.325725845317823 no 1131 0.252595441216987 279 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1097 itavastatin 7.23 µM 0.665828376575869 0.325864137516696 no 1132 0.252760402455637 275 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2249 haloperidol 116.36 µM 0.663107913462436 0.32659336383018 no 1133 0.253630721397048 284 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1451 4152-0210 104 µM 0.660517466574126 0.327288355424504 no 1134 0.254460906735235 298 659563
SGTC_2101 5377231 179.231 µM 0.65894072312805 0.327711673796526 no 1135 0.254966917051992 300 2844213
SGTC_3341 9147222 25.867 µM 0.658550949366503 0.327816353015218 no 1136 0.255092084809428 291 1939759
SGTC_1697 st025554 27.742 µM 0.658381373593493 0.327861899195515 no 1137 0.255146550582564 281 1269519
SGTC_1323 1348-1351 11.2 µM 0.650528917531352 0.329973777197669 no 1138 0.25767531443193 278 6989654
SGTC_2317 5986382 200 µM 0.649770962302104 0.330177913822733 no 1139 0.257920089157569 321 877883
SGTC_781 4335-2806 94.4 µM 0.649321232696259 0.330299061351963 no 1140 0.258065382234367 314 845254
SGTC_2448 5185112 27.17 µM 0.648626232116449 0.33048631461845 no 1141 0.258289997876053 269 5718189
SGTC_1169 aniline yellow 25.8 µM 0.645702452094609 0.33127452998537 no 1142 0.25923603612739 294 6051 A DNA damaging agent.
SGTC_2257 7960413 200 µM 0.645566009093825 0.331311331647642 no 1143 0.259280228253779 281 2974689 YIL048W NEO1
SGTC_2316 5844804 197.44 µM 0.642899493265888 0.332030875950707 no 1144 0.26014465912714 283 776813
SGTC_1032 k061-1018 98.7 µM 0.642657947495425 0.332096086374557 no 1145 0.260223036729671 293 4005393
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.639112793426771 0.333053760327699 no 1146 0.26137477892569 321 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_156 3474-0145 5.642 µM 0.639092595664391 0.333059219599517 no 1147 0.26138134822492 275 2265471
SGTC_2878 9043973 25.97 µM 0.635560929885823 0.334014339845677 no 1148 0.262531320816294 306 6465167
SGTC_2104 5389443 200 µM 0.630591838080783 0.335360025674054 no 1149 0.264153718463685 297 2244536
SGTC_2474 5321570 43.32 µM 0.629819286581203 0.335569431710865 no 1150 0.264406412799399 301 2841384
SGTC_1836 st055642 81 µM 0.627445193793218 0.336213267311514 no 1151 0.265183725517145 301 8571
SGTC_1997 st073024 93.8 µM 0.62744021591258 0.336214617779903 no 1152 0.265185356566394 290 686268
SGTC_1668 st014914 51.6 µM 0.625367765900494 0.336777044155217 no 1153 0.265864856506361 303 2839556
SGTC_2623 humulene 100 µM 0.624847792051157 0.336918213247386 no 1154 0.266035480132306 286 6187145 An anti-inflammatory.
SGTC_1560 lithocholic acid 53.1 µM 0.61922546443176 0.338446097720262 no 1155 0.267883919357951 290 9903 A bile acid which acts as a detergent.
SGTC_1130 3454-2858 15.9 µM 0.61861621018213 0.338611824785834 no 1156 0.268084610199754 313 715628 YIL048W NEO1
SGTC_771 0250-0039 27.3 µM 0.616306938935149 0.339240267649985 no 1157 0.268845980021183 315 3005115
SGTC_2450 5739737 12.93 µM 0.615919056351139 0.339345869583527 no 1158 0.268973971862896 302 2262825
SGTC_1705 st027868 56.3335 µM 0.614566312944373 0.33971425580934 no 1159 0.269420583591686 306 292948
SGTC_741 4582-0002 126 µM 0.613171153582243 0.340094353414843 no 1160 0.269881588150185 308 2912688
SGTC_481 bay k-8644 50 µM 0.611167960061725 0.340640388238132 no 1161 0.270544196125004 313 2303 A calcium channel antagonist.
SGTC_1139 k015-0024 46.9 µM 0.611036744566651 0.340676166914106 no 1162 0.270587627382301 303 2766652
SGTC_367 0335-0881 7.1 µM 0.610750776285357 0.340754147171717 no 1163 0.270682292612128 313 23828853
SGTC_36 0335-0881 14.2 µM 0.60642575834766 0.341934357932338 no 1164 0.272116034059641 294 23828853
SGTC_1334 1486-0610 236 µM 0.606057923112907 0.342034804304558 no 1165 0.272238145244958 299 3742339
SGTC_1767 st044992 70.3 µM 0.604109145724698 0.342567151826324 no 1166 0.2728855397147 307 9600693
SGTC_2892 9047358 58.44 µM 0.602712054351708 0.342948987894657 no 1167 0.273350130507498 306 6466771
SGTC_532 1548-0774 215 µM 0.60259859140408 0.342980005261148 no 1168 0.273387878831536 331 5932993
SGTC_1478 0453-0656 35.7 µM 0.601891271086228 0.34317338927247 no 1169 0.273623257507531 315 5258496
SGTC_999 SEC7.066 22.7 µM 0.600999942018731 0.343417140455168 no 1170 0.273920012459272 310 740511 YDR170C SEC7
SGTC_2922 7999257 32.47 µM 0.599421827067411 0.343848866242701 no 1171 0.274445812606556 313 2988377
SGTC_184 1494-0393 24.714 µM 0.596983411947386 0.344516345199057 no 1172 0.275259227811999 305 3090647
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.596267584178526 0.3447123842106 no 1173 0.275498241315973 322 7104
SGTC_709 3807-1509 243 µM 0.5960141958598 0.344781787988924 no 1174 0.275582871640925 334 1886677 YPL242C IQG1
SGTC_2885 9057732 51.95 µM 0.594806524578443 0.345112644319379 no 1175 0.275986402878971 313 6471414
SGTC_111 0083-0039 52.457 µM 0.593777449609372 0.345394665474563 no 1176 0.276330486786447 296 759313
SGTC_1719 st032227 49.2 µM 0.591734854599572 0.345954699120077 no 1177 0.277014076407388 291 3125804
SGTC_263 alizarin 107.927 µM 0.590835520872266 0.346201383191422 no 1178 0.277315316183024 315 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_279 1273-0055 2.93 µM 0.590754378261919 0.346223643535042 no 1179 0.277342503494064 316 2847562
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.59057878145943 0.346271817887908 no 1180 0.27740134270196 316 4620898
SGTC_2675 theaflavin digallate 100 µM 0.590507900500792 0.346291264529348 no 1181 0.277425095315753 295 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2222 6885208 172.143 µM 0.589745405626373 0.346500485461603 no 1182 0.277680674557163 288 609514
SGTC_2596 sinensetin 100 µM 0.58689245204198 0.347283722284281 no 1183 0.278637969698019 307 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1151 3909-8316 15.3 µM 0.585366579100014 0.347702896564713 no 1184 0.279150627948529 320 800431
SGTC_1064 honokiol 6.76 µM 0.585365385614525 0.347703224501422 no 1185 0.279151029111633 308 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1029 k015-0030 64.7 µM 0.585041184937846 0.347792310073807 no 1186 0.279260012200033 306 2208316
SGTC_10 0279-0212 42.575 µM 0.580969630319641 0.348911827417096 no 1187 0.280630460968979 291 39851 YBR002C RER2
SGTC_746 1095-0025 46.6 µM 0.578370241699082 0.349627246271891 no 1188 0.281507090269771 317 6749286
SGTC_426 0988-0037 14.6 µM 0.57742844731853 0.349886584414233 no 1189 0.281825030874283 311 5383008
SGTC_2457 5731572 11.68 µM 0.570958515520745 0.351670071399174 no 1190 0.284013881960016 342 2865357
SGTC_2525 harmine 47.85 µM 0.569559710227224 0.352056094160148 no 1191 0.284488180746047 306 5280953 A monoamine oxidase inhibitor
SGTC_1388 3346-4487 254 µM 0.568264795180274 0.352413582699809 no 1192 0.284927589997766 341 3345614
SGTC_670 4204-0025 119 µM 0.567626662897419 0.352589800531564 no 1193 0.285144249256133 330 719039
SGTC_1075 aripiprazole 15.2 µM 0.566836668199435 0.352807998424597 no 1194 0.285412577709395 301 60795 An atypical antipschotic. YIL048W NEO1
SGTC_366 0181-0206 4.31 µM 0.564853790703926 0.35335588576994 no 1195 0.2860866081627 322 274874
SGTC_283 0987-0079 11.7 µM 0.564416440923887 0.353476770513454 no 1196 0.286235376206702 308 411556
SGTC_2678 equilin 100 µM 0.561204619690731 0.35436497933751 no 1197 0.287329027015211 284 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_168 3970-0862 530.542 µM 0.559258906430077 0.354903439919901 no 1198 0.28799251812068 326 3135186
SGTC_1780 st038448 24.544 µM 0.558195375111 0.355197886341887 no 1199 0.288355489326653 330 728868 YDL195W SEC31
SGTC_1524 corynanthine 62.1 µM 0.558137436817746 0.355213929467417 no 1200 0.288375269204154 338 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_703 3875-0075 71.8 µM 0.557676077194205 0.355341689199759 no 1201 0.288532798164923 342 2850814
SGTC_293 4049-0273 38.5 µM 0.555959595309079 0.355817160135341 no 1202 0.289119238181991 308 1380311
SGTC_3133 9127736 49.47 µM 0.555819180862913 0.355856065321243 no 1203 0.28916723589382 319 27243420
SGTC_701 4424-0219 185 µM 0.555518645491552 0.355939340890009 no 1204 0.289269980149813 319 2911779
SGTC_1981 st071826 47 µM 0.554892251717415 0.356112930894879 no 1205 0.289484180997597 304 11838600
SGTC_121 0557-0495 61.343 µM 0.552327993094814 0.356823864286413 no 1206 0.290361827479873 334 3104427
SGTC_2701 st077767 14.721 µM 0.55207949332949 0.356892786623144 no 1207 0.290446945509671 322 5721188
SGTC_930 2810-3379 265 µM 0.551994957777794 0.356916233938677 no 1208 0.290475903932144 330 1015764
SGTC_1677 st019204 53.9 µM 0.548395590496188 0.357915077656834 no 1209 0.291710151768877 309 3945625
SGTC_2047 4141938 200 µM 0.548072633361245 0.358004747688744 no 1210 0.291821015383447 331 3807862
SGTC_1266 0828-0227 32.9 µM 0.547830439901382 0.358071998581355 no 1211 0.291904167598918 320 3913820
SGTC_1814 st052110 31.539 µM 0.547143313680908 0.358262819820633 no 1212 0.29214013850433 328 674163
SGTC_3145 9085516 49.47 µM 0.547040322064164 0.358291424587382 no 1213 0.292175515236899 331 25236195
SGTC_1158 4092-0494 91.8 µM 0.54463991600075 0.358958335428145 no 1214 0.293000598062188 326 1148199
SGTC_2182 6325192 200 µM 0.542565728939428 0.359534958546771 no 1215 0.293714420256985 307 736248
SGTC_3148 9097893 49.47 µM 0.541689869142007 0.359778543359023 no 1216 0.294016084975937 274 17174100
SGTC_2281 7943571 200 µM 0.541528664086612 0.359823382204962 no 1217 0.294071623025179 332 1244024
SGTC_1432 4049-0298 68.4 µM 0.540883471730986 0.360002860404618 no 1218 0.29429395195445 343 741646
SGTC_76 0433-0009 400.328 µM 0.539350217067755 0.360429501613185 no 1219 0.294822612365437 359 2841569
SGTC_1491 4138-0063 26.5 µM 0.538694081882958 0.360612129977248 no 1220 0.295048978976396 335 23883227
SGTC_1638 st008370 60.6 µM 0.538269616956114 0.360730292290373 no 1221 0.295195461992463 301 24207134
SGTC_2074 5212007 75.395 µM 0.53633308725207 0.361269550931767 no 1222 0.295864183587125 316 758611
SGTC_1279 0874-0590 65.2 µM 0.535459563814016 0.361512888263275 no 1223 0.296166055853787 331 3523074
SGTC_2682 pyrogallin 40.03 µM 0.535402699114003 0.361528731000045 no 1224 0.296185712057138 312 822798 An ATP competetive kinase inhibitor.
SGTC_2842 9000675 19.48 µM 0.533613492580606 0.362027332341475 no 1225 0.296804485649595 317 2989072
SGTC_2524 avocatin b 10.57 µM 0.531755365316461 0.362545387902491 no 1226 0.297447720195336 311 6710748
SGTC_1305 1181-0477 144 µM 0.531623980372159 0.362582028250735 no 1227 0.297493226279392 327 6252086
SGTC_2246 7293507 91.5585 µM 0.530732416217457 0.362830698959627 no 1228 0.297802109630528 323 887656
SGTC_545 4218-0007 221 µM 0.529916134994427 0.363058422860375 no 1229 0.298085039331365 339 2840508
SGTC_2055 5235184 200 µM 0.529137923731592 0.363275571199948 no 1230 0.298354887657096 359 2836034
SGTC_585 0kpi-0023 191 µM 0.528734174056382 0.363388248893846 no 1231 0.29849493350585 322 64601
SGTC_463 ikarugamyin 104 µM 0.528658739477652 0.363409302343978 no 1232 0.298521102290337 354 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_528 3492-0019 172 µM 0.527859417260474 0.363632414901243 no 1233 0.298798456870589 339 2869262
SGTC_2329 6138490 200 µM 0.525696941666759 0.36423625227131 no 1234 0.299549394541432 368 720019
SGTC_1154 4088-0362 150 µM 0.525058148967574 0.364414689682373 no 1235 0.299771384169252 326 6618304
SGTC_1166 k206-0078 225 µM 0.522991387803626 0.3649922104024 no 1236 0.300490123224532 315 5404595
SGTC_540 1187-0821 17.3 µM 0.518669301463895 0.366200931833786 no 1237 0.301995686368608 338 847520
SGTC_232 clozapine 119 µM 0.517602722839328 0.366499417766437 no 1238 0.30236774082281 336 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2506 ethyl hematommate 54.16 µM 0.516068790420543 0.366928835940944 no 1239 0.302903182365892 337 3940691 An allergen.
SGTC_1546 5-methoxyflavanone 78.7 µM 0.513006303961059 0.367786664395986 no 1240 0.303973455509401 316 147795
SGTC_1499 4480-0877 67.3 µM 0.511825936756254 0.368117471702688 no 1241 0.3043864181554 338 2861909
SGTC_210 3551-0445 56.827 µM 0.511634144762129 0.368171232180549 no 1242 0.30445354198182 340 2865180 YOR207C RET1
SGTC_3246 9135460 32.98 µM 0.50987297286177 0.368665020092655 no 1243 0.305070228913643 360 41446951
SGTC_1345 1488-0192 31.4 µM 0.509171484285077 0.368861760144788 no 1244 0.305316014514873 347 658348
SGTC_3095 9117207 49.47 µM 0.508403961612817 0.369077059546101 no 1245 0.305585037546272 324 17015229
SGTC_990 3985-0011 41.3 µM 0.507835176187373 0.369236637250713 no 1246 0.30578446927452 357 5399565 YGL099W LSG1
SGTC_3224 9130643 49.47 µM 0.506785861848503 0.369531090646676 no 1247 0.306152538734616 323 17644395
SGTC_2389 9091542 195.52 µM 0.50550597525161 0.369890349690572 no 1248 0.306601751359353 334 3626624 YOL127W RPL25
SGTC_1567 st069303 68.4 µM 0.505494638651197 0.36989353233685 no 1249 0.306605731561676 353 5581319
SGTC_3061 glucosamine 200 µM 0.504901225628793 0.370060140020699 no 1250 0.306814106622625 324 91431 and experimental redox chemotherapeutic
SGTC_1910 st062352 60.4 µM 0.504592210105843 0.370146909420765 no 1251 0.306922641150428 326 2245730
SGTC_410 α-linolenic acid 100 µM 0.504327154647338 0.370221340407769 no 1252 0.307015749211023 340 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3143 9086658 49.47 µM 0.501660403095711 0.370970468587496 no 1253 0.307953211224443 341 25236626
SGTC_2708 st078559 56 µM 0.501190767896748 0.371102446498738 no 1254 0.308118435512419 319 17250902
SGTC_1171 0368-0077 21.4 µM 0.500497580170173 0.371297275331434 no 1255 0.308362379797818 355 3239779
SGTC_1460 k062-0059 9.15 µM 0.496590692961384 0.372395968970345 no 1256 0.309738858822698 321 1373085
SGTC_3197 9113331 49.47 µM 0.496567081308426 0.372402612200806 no 1257 0.30974718585004 317 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2085 5307070 144.047 µM 0.495923993382897 0.372583562084481 no 1258 0.309974018630187 362 2840351
SGTC_1806 st050005 60.3 µM 0.491017151112989 0.37396515596598 no 1259 0.311707158501069 317 5194765
SGTC_2217 6934799 96.0675 µM 0.49033967477719 0.374156037159368 no 1260 0.311946778282543 343 675606
SGTC_3275 9138069 49.47 µM 0.489938254306957 0.374269153263252 no 1261 0.312088796137889 336 17617007
SGTC_2243 6634756 200 µM 0.488589831147905 0.374649204052797 no 1262 0.312566056853815 298 885676
SGTC_626 0214-0009 33 µM 0.487793376169943 0.374873740782295 no 1263 0.31284810182447 350 3437874
SGTC_1123 mangostin 811.285 nM 0.484786205068326 0.375721904874594 no 1264 0.313914004584783 318 5281650 An antioxidant.
SGTC_1199 1638-0010 4.46 µM 0.484378182215535 0.375837032950673 no 1265 0.314058749747089 336 3111136
SGTC_1016 4226-1401 38 µM 0.483590157814419 0.376059413869422 no 1266 0.314338380547696 334 2901613
SGTC_501 nsc-95397 161 µM 0.483529863719003 0.376076430592361 no 1267 0.31435978032474 355 262093
SGTC_2313 7726885 200 µM 0.483084116141673 0.376202240815586 no 1268 0.314518005860842 320 726423
SGTC_1850 st056238 17 µM 0.4830084859552 0.376223588397047 no 1269 0.314544855438673 356 5393177
SGTC_873 0591-4978 488 µM 0.481476136367768 0.376656195025366 no 1270 0.315089068095021 363 3305145
SGTC_2515 chrysin 20.77 µM 0.481343468211589 0.37669365664874 no 1271 0.315136203985246 331 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_411 enrofloxacin 100 µM 0.480817671691447 0.376842137689242 no 1272 0.315323044706258 360 71188 A bacterial gyrase inhibitor.
SGTC_707 0865-0008 204 µM 0.480559530253768 0.376915041587013 no 1273 0.315414792032238 339 723043
SGTC_1269 0831-0796 3.05 µM 0.480487072842217 0.37693550568385 no 1274 0.315440546525496 346 927758
SGTC_1459 k035-0031 35.7 µM 0.480172377861316 0.377024388781271 no 1275 0.315552413115005 332 3877128 YMR208W ERG12
SGTC_2130 NSC 7 2.4545 µM 0.480038667185887 0.377062156272346 no 1276 0.315599949201435 332 21448
SGTC_274 sirtinol 40.1 µM 0.476524376776116 0.378055212216881 no 1277 0.316850422467835 320 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1570 verbenone 133 µM 0.476229670468397 0.378138526029745 no 1278 0.316955381827357 366 29025 A natural terpanoid with antifungal properties.
SGTC_2224 6650123 117.647 µM 0.474823822552613 0.378536038789991 no 1279 0.31745627580552 352 2908370
SGTC_2336 9001819 198.65 µM 0.473676810350222 0.378860459304473 no 1280 0.317865196198366 369 2989602
SGTC_2273 7815444 169.05 µM 0.472979518546969 0.379057722802239 no 1281 0.318113895776525 395 2824616
SGTC_1215 3852-0577 11.2 µM 0.47287261383329 0.379087968877826 no 1282 0.318152032200898 329 2884876
SGTC_1320 1313-0481 95.3 µM 0.472663998227429 0.379146993695821 no 1283 0.318226457794442 329 6813365 YLR208W SEC13
SGTC_742 0kpi-0133 140 µM 0.471726191359248 0.379412367594267 no 1284 0.318561119894047 369 2728852
SGTC_1378 2093-0007 380 nM 0.470726617521306 0.379695282428993 no 1285 0.318917986942236 384 3618014
SGTC_1548 st061468 90.8 µM 0.469256938392357 0.380111370669722 no 1286 0.31944299553904 360 390799
SGTC_231 b-estradiol 524 µM 0.467381992033755 0.380642397584422 no 1287 0.320113302072876 328 450 A steroid.
SGTC_3112 9123419 49.47 µM 0.466849336433386 0.380793298687796 no 1288 0.320303837471687 357 17015854
SGTC_3067 9117431 49.47 µM 0.46323034681181 0.381819035986526 no 1289 0.321599633096731 369 17150885
SGTC_2723 salbutamol 83.58 µM 0.461269663537705 0.38237510352882 no 1290 0.322302573496178 362 9884233 β2-adrenoceptor agonist
SGTC_3023 9089636 49.47 µM 0.460797750510761 0.382508978612563 no 1291 0.322471857893277 355 17249241
SGTC_2236 dapsone 200 µM 0.459482050844486 0.382882298196544 no 1292 0.322944019311351 333 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_671 0560-0003 407 µM 0.453707109499374 0.384522175874063 no 1293 0.325019824583284 376 3238678
SGTC_1635 st007035 42.4 µM 0.453472627569656 0.384588804289482 no 1294 0.325104224642794 337 3716403
SGTC_3029 9088683 49.47 µM 0.45214399671917 0.38496640120558 no 1295 0.325582625014593 324 25236615
SGTC_1878 temozolomide 1 mM 0.451122833544271 0.385256689985035 no 1296 0.325950510859312 363 5394 DNA alkylating agent.
SGTC_892 0929-0076 29 µM 0.447051466762992 0.386414706083334 no 1297 0.327418950022268 346 5751038
SGTC_466 geldanamycin 89.2 µM 0.446950431249366 0.386443456461566 no 1298 0.327455425077817 348 5288382 HSP90 inhibitor.
SGTC_3066 9117245 49.47 µM 0.446785345906235 0.386490434018407 no 1299 0.327515026449121 350 17176980
SGTC_3263 9137018 49.47 µM 0.444247063477836 0.387212950119819 no 1300 0.328431984595478 356 43844957
SGTC_2801 7907800 81.82 µM 0.443553631463542 0.387410401995206 no 1301 0.328682668021875 371 6620925
SGTC_2521 angolensin 13.4 µM 0.442778837564111 0.38763105578228 no 1302 0.328962855893639 364 821428 A flavenoid.
SGTC_737 1950-0117 57.9 µM 0.441498975954669 0.387995627425717 no 1303 0.329425901355438 348 5393513
SGTC_2844 9010103 25.97 µM 0.441493809927043 0.387997099181346 no 1304 0.329427770920799 371 2480525
SGTC_312 4092-0653 6.84 µM 0.441155535916085 0.388093473959133 no 1305 0.32955020025255 343 1148278
SGTC_1356 1502-0781 85.8 µM 0.439261951029268 0.388633086277032 no 1306 0.330235870315621 344 567702
SGTC_1423 4048-0112 5.59 µM 0.438561461970495 0.38883275822154 no 1307 0.330489663183547 365 X1423
SGTC_2928 9011484 9.79 µM 0.436962039723908 0.389288777922573 no 1308 0.3310694389693 375 2994751
SGTC_686 1319-0111 510 µM 0.432931435863638 0.390438639782781 no 1309 0.332532290730347 391 4562600
SGTC_1025 k007-0731 70 µM 0.432263060044868 0.390629408857119 no 1310 0.332775115939466 351 6256118
SGTC_2396 5342950 42.78 µM 0.432185433378519 0.390651566912622 no 1311 0.332803322753285 366 1886677
SGTC_1521 st012942 49.4 µM 0.431577934922896 0.390824985876555 no 1312 0.333024099102093 331 24207259
SGTC_2546 rhodinyl acetate 100 µM 0.43137214272063 0.390883737075828 no 1313 0.333098900983983 352 6708682
SGTC_1781 st038725 66.3 µM 0.430587314968474 0.39110781881274 no 1314 0.333384233137405 343 4270275 YIL048W NEO1
SGTC_2447 5741742 33.78 µM 0.429084393451729 0.39153702943967 no 1315 0.333930904668219 344 1776504
SGTC_161 4065-0411 162.148 µM 0.428279458365582 0.391766960522562 no 1316 0.334223836224026 373 1906281 YLR208W SEC13
SGTC_857 0438-0306 1.35 µM 0.42627743325358 0.392339006230524 no 1317 0.334952849831957 335 4686136
SGTC_2718 lomofungin 53.02 µM 0.425739860918508 0.392492648358315 no 1318 0.335148706498993 368 5351222 A RNA synthesis inhibitor.
SGTC_1051 3253-3903 78 µM 0.424604224690558 0.392817276611341 no 1319 0.335562606381921 367 5509239
SGTC_2768 sulfasalazine 50.2 µM 0.422503488954663 0.393417980596841 no 1320 0.336328777314072 370 5384001 An antioxidant and salicylic acid derivative.
SGTC_3309 9129340 25.759 µM 0.421667572686704 0.393657080965538 no 1321 0.336633838325884 345 17158987
SGTC_291 SEC14.278 35.5 µM 0.420266055667446 0.394058052248926 no 1322 0.337145552074658 361 1068044
SGTC_1612 st002233 45.4 µM 0.419694768103129 0.394221528754019 no 1323 0.337354223811596 363 1035021
SGTC_886 0866-0150 153 µM 0.415918534971132 0.395302582281739 no 1324 0.338734808040915 381 271463
SGTC_824 1304-0008 100 µM 0.415749084871872 0.395351111127335 no 1325 0.33879680969546 373 768245
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.413628986121878 0.395958423552199 no 1326 0.339572920857833 389 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1726 st035556 14.5795 µM 0.412271092984824 0.396347531353975 no 1327 0.34007036692802 340 5919439
SGTC_2915 7971052 15.16 µM 0.410920423391688 0.396734671682218 no 1328 0.340565443089824 368 5741558
SGTC_2555 cholic acid 100 µM 0.410838345378155 0.396758200860993 no 1329 0.34059553693621 369 6708657 Influences liver metabolism.
SGTC_2850 9015429 58.44 µM 0.410048277865571 0.396984707519874 no 1330 0.340885266511785 370 6457570
SGTC_1926 methyl fluorone black 53.6 µM 0.409661163137343 0.39709570321262 no 1331 0.341027261550747 348 72721 Reacts with homocysteine.
SGTC_2949 9072542 2.23 µM 0.40913014060142 0.39724797451216 no 1332 0.341222079108239 368 16457352
SGTC_3031 9088762 49.47 µM 0.407284907570309 0.39777721875876 no 1333 0.341899373150469 369 205253
SGTC_681 1642-0006 26.6 µM 0.406495887597448 0.39800358061459 no 1334 0.342189139000163 402 4446530
SGTC_61 0978-8327 98.565 µM 0.403734774529238 0.398795985897186 no 1335 0.343203882498497 377 6150059 YHR072W ERG7
SGTC_327 1273-0057 3.96 µM 0.403101920395396 0.398977666109719 no 1336 0.343436623960093 377 3108138
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.40271656932914 0.399088303690804 no 1337 0.343578371602584 392 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2277 7947813 106.88 µM 0.4026706875078 0.399101477293702 no 1338 0.343595250250343 393 1246798
SGTC_2066 5222451 176 µM 0.402498424618065 0.399150938494051 no 1339 0.343658623766125 359 2281147
SGTC_3005 9076496 71.4286 µM 0.398272489242757 0.40036482074319 no 1340 0.345214668557896 381 21368410
SGTC_1704 st028805 70.8 µM 0.397622819987607 0.400551521218818 no 1341 0.345454118331006 362 2876101
SGTC_2865 9030313 51.95 µM 0.397299312107915 0.400644498656372 no 1342 0.345573377293591 360 42562754
SGTC_1490 4089-0339 670 nM 0.397254795905309 0.4006572932289 no 1343 0.345589789086632 384 742542
SGTC_1745 st081495 74 µM 0.396686773271399 0.400820560144804 no 1344 0.345799227519558 363 13842402 YBL026W LSM2
SGTC_2460 5552655 174.22 µM 0.396289603233158 0.400934729142206 no 1345 0.345945698088905 353 5401989
SGTC_927 2425-1185 123 µM 0.395091423124151 0.401279204694529 no 1346 0.346387709206201 400 730375
SGTC_139 0099-0334 718.624 µM 0.391756064879104 0.402238520159588 no 1347 0.347619230275706 371 97690
SGTC_987 1497-1013 404 µM 0.387818988612544 0.403371659514875 no 1348 0.349074996162169 410 1676435
SGTC_542 3381-0244 89.3 µM 0.387527498069698 0.403455586497031 no 1349 0.349182865833791 421 1112843
SGTC_2216 7189485 200 µM 0.386962751981406 0.403618202826075 no 1350 0.349391891759548 373 731273
SGTC_262 fenpropimorph 62.5 µM 0.385824797722364 0.403945922695188 no 1351 0.34981321434057 389 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2275 7947463 200 µM 0.385548737370553 0.404025435590802 no 1352 0.349915452381663 372 1225414
SGTC_182 3448-4371 550.524 µM 0.383694645181643 0.404559567209635 no 1353 0.350602390965954 349 3491403
SGTC_805 3852-0218 479 µM 0.382429062010853 0.404924261877537 no 1354 0.351071568632913 363 6615355
SGTC_1442 4112-3290 3 µM 0.380518169872463 0.405475067335547 no 1355 0.351780405759284 387 704353
SGTC_2482 5981709 142.65 µM 0.379265073254756 0.405836368124435 no 1356 0.352245516556027 386 877755
SGTC_884 0851-0618 334 µM 0.377249690199594 0.406417624339072 no 1357 0.352994028047555 405 9642473
SGTC_363 0455-0021 3.06 µM 0.377109067400635 0.406458189045111 no 1358 0.353046276509042 397 4597466
SGTC_1372 2752-0194 270 µM 0.377072897105753 0.406468623058786 no 1359 0.353059716045717 366 823334
SGTC_2803 7707263 71.43 µM 0.373438433217963 0.407517391107979 no 1360 0.354411079705168 383 2199229
SGTC_2064 5220758 200 µM 0.371903160355789 0.407960612156834 no 1361 0.354982476011442 359 788518
SGTC_730 1436-0052 41.2 µM 0.370520792168422 0.408359791654665 no 1362 0.355497243653128 361 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1344 1488-0097 29.1 µM 0.370413489508966 0.408390780886262 no 1363 0.355537212165353 389 747966
SGTC_1148 3909-7663 27.7 µM 0.370267267911566 0.408433010910447 no 1364 0.355591679912413 386 4084526
SGTC_2159 5658611 73.75 µM 0.370162350166202 0.40846331269087 no 1365 0.35563076373472 402 793844
SGTC_1342 1486-1464 234 µM 0.369850733347307 0.408553315415028 no 1366 0.355746855775477 399 3253938
SGTC_1848 st056003 16.4 µM 0.369795849091028 0.408569167859431 no 1367 0.355767304149508 376 146492
SGTC_493 zm226600 134 µM 0.368291026161754 0.409003870222655 no 1368 0.356328121554451 404 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.368111887473002 0.409055625977937 no 1369 0.35639490368998 367 16725076
SGTC_3171 9103192 49.47 µM 0.368013710015113 0.409083991536604 no 1370 0.356431505693888 394 13018434
SGTC_2732 terfenadine 20 µM 0.367345725740768 0.409276999053098 no 1371 0.356680575174242 412 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1182 1222-0449 220 µM 0.365276906021716 0.4098749036047 no 1372 0.357452357741658 381 658318
SGTC_1776 st049249 45.9 µM 0.36353342171666 0.410378946591494 no 1373 0.358103225613215 372 1822314
SGTC_1100 amiodarone 5.07 µM 0.361995639977503 0.410823643701126 no 1374 0.358677644303891 375 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2944 9067346 25.62 µM 0.361622029755571 0.410931701973859 no 1375 0.358817249960812 389 6473075
SGTC_577 r071-0003 38.6 µM 0.360946416976013 0.411127124786697 no 1376 0.359069751767995 396 4568517 YMR134W ERG29
SGTC_404 fumagillin 50 µM 0.360191892222998 0.411345399169795 no 1377 0.359351818723431 372 12015870 A methionine aminopeptidase binder.
SGTC_2131 toluylene red 5.2905 µM 0.359424154967655 0.411567523931211 no 1378 0.359638903654103 343 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2730 imipramine 71.33 µM 0.357787625836704 0.412041105499157 no 1379 0.360251125782639 353 3696 A tricyclic antidepressant.
SGTC_1872 amphotericin b 148 nM 0.355035687302619 0.412837754677844 no 1380 0.361281427966585 415 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1267 0828-0272 9.49 µM 0.352644366496923 0.413530301624871 no 1381 0.362177536025065 386 745334
SGTC_678 1218-2179 85.9 µM 0.350946436154699 0.414022200260731 no 1382 0.362814266660573 404 6820081 YOR116C RPO31
SGTC_1136 pergolide 1.05886 µM 0.347686955234389 0.414966865123905 no 1383 0.364037647195414 403 47811 A dopamine receptor agonist.
SGTC_2290 7904846 200 µM 0.346843327400455 0.415211446237239 no 1384 0.364354512362769 374 2962154
SGTC_3091 9116372 49.47 µM 0.346379958581351 0.415345798207858 no 1385 0.36452859236316 372 17169793
SGTC_2855 9016525 58.44 µM 0.346039160925101 0.415444617469024 no 1386 0.364656642239975 401 43811474
SGTC_458 nppb 133 µM 0.346009692417604 0.41545316254477 no 1387 0.364667715322499 376 4549 A chloride channel blocker.
SGTC_2597 laccaic acid a 100 µM 0.344724504801448 0.415825871282137 no 1388 0.365150746973363 404 5491415 A textile dye.
SGTC_1899 st063254 59.6 µM 0.341632591024406 0.41672284631686 no 1389 0.366313703627396 377 3093813
SGTC_2958 9077254 16.72 µM 0.339173616995361 0.417436513202742 no 1390 0.367239471557693 373 16457351
SGTC_2883 9059145 45.46 µM 0.337271444509269 0.417988766596686 no 1391 0.367956141941261 428 16476510
SGTC_100 0086-0128 49.5915 µM 0.335551369536306 0.418488291333777 no 1392 0.368604600564465 415 93297
SGTC_1453 4237-0541 195 µM 0.334168686235544 0.4188899299597 no 1393 0.369126135930427 379 739892
SGTC_2724 maprotiline 69.64 µM 0.331585076658086 0.419640637149489 no 1394 0.370101294868927 410 4011 A tricyclic antidepressant.
SGTC_3181 9108277 49.47 µM 0.329515337557673 0.420242242626866 no 1395 0.370883101494401 419 17097298
SGTC_1742 st038235 28.8875 µM 0.329291060924729 0.420307443727901 no 1396 0.370967850031903 445 564103 YBR002C RER2
SGTC_2449 5812982 45.77 µM 0.327147783267847 0.420930641715158 no 1397 0.371778056288599 403 776185
SGTC_615 k087-0205 167 µM 0.325959618773354 0.421276208210759 no 1398 0.37222745374877 404 9642773
SGTC_3276 9139060 49.47 µM 0.324006444756435 0.421844402226985 no 1399 0.372966577502823 436 4870619
SGTC_2871 9038510 12.99 µM 0.322865496299179 0.422176388675826 no 1400 0.373398553999208 425 4945164
SGTC_513 4245-1575 41.7 µM 0.321308982093003 0.422629383136264 no 1401 0.373988125143392 400 719745
SGTC_3063 1327-0034 4 µM 0.320771890418895 0.422785717441372 no 1402 0.374191631404267 428 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_840 0245-0196 390 µM 0.32071447327141 0.422802430894559 no 1403 0.374213389074891 390 3827528
SGTC_2424 5537928 59.2 µM 0.319732997510248 0.423088148356719 no 1404 0.374585371693169 424 5382802
SGTC_1471 k673-0312 37 µM 0.3174632309668 0.423749054940042 no 1405 0.375446067513587 409 24099884
SGTC_637 1181-0519 7.26 µM 0.316990023167593 0.423886869834203 no 1406 0.375625586271926 428 6252091 YGR060W ERG25
SGTC_904 1141-0088 396 µM 0.316930866239543 0.423904099084721 no 1407 0.375648030269623 409 1378119
SGTC_1822 st052468 42 µM 0.315017883706176 0.42446132684951 no 1408 0.376374037711743 388 2873678
SGTC_754 3474-0146 171 µM 0.314018296494096 0.424752554180624 no 1409 0.376753571270054 375 24762078
SGTC_2391 6285546 200 µM 0.313065193822433 0.42503027661242 no 1410 0.377115566072108 383 846083
SGTC_506 n9-isopropylolomoucine 153 µM 0.312777978816484 0.425113974846077 no 1411 0.377224673458013 415 6610355
SGTC_2006 4011487 200 µM 0.312535226283406 0.425184718762167 no 1412 0.377316898060301 385 45595294
SGTC_188 3229-0966 278.469 µM 0.311788320757678 0.425402400063897 no 1413 0.377600700302392 408 5722370
SGTC_1711 st032263 62.8 µM 0.3106251813041 0.425741435599846 no 1414 0.378042790818535 430 3958979
SGTC_2469 5655019 90.81 µM 0.31057537147885 0.425755955551686 no 1415 0.378061726299457 434 2788239
SGTC_1444 4112-3581 28 µM 0.308947320858969 0.426230600291749 no 1416 0.378680799771596 399 2877249
SGTC_950 1165-0508 94.1 µM 0.308678118073092 0.426309094460914 no 1417 0.378783195373615 405 6148369
SGTC_798 1287-0182 476 µM 0.308026458469539 0.426499117499091 no 1418 0.379031099783809 435 1649755
SGTC_452 diindolylmethane 8 µM 0.306902057663946 0.426827031313262 no 1419 0.379458961409822 437 3071 Inhibits expression of several cancer promoting factors.
SGTC_1986 st071812 45 µM 0.306498510571468 0.426944731822389 no 1420 0.379612556847767 433 11838594
SGTC_1449 4112-4002 201 µM 0.303741036124114 0.427749163786768 no 1421 0.380662595890393 397 2059539
SGTC_1094 duloxetine 25.4 µM 0.303635901884971 0.427779840334045 no 1422 0.380702648191388 374 60834 A selective serotonin reuptake inhibitor.
SGTC_1197 1601-0112 267 µM 0.302434267590127 0.428130489628088 no 1423 0.381160517642595 407 7350313
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.302081892360824 0.428233327133011 no 1424 0.381294817909218 416 97141
SGTC_134 0269-0018 6.916 µM 0.30142464884678 0.428425150691772 no 1425 0.381545350377873 411 4378915
SGTC_635 k038-0028 24.7 µM 0.300300184042745 0.428753376982823 no 1426 0.381974096431368 429 4035102
SGTC_699 0375-0592 111 µM 0.299246062457547 0.429061115158035 no 1427 0.382376152896937 401 762578
SGTC_63 0099-0242 26.702 µM 0.29709138070666 0.429690282666152 no 1428 0.383198372329905 409 3898502 YLR359W ADE13
SGTC_2799 7812892 81.82 µM 0.293302165932563 0.430797166457686 no 1429 0.38464559912086 418 20205235
SGTC_1690 st023502 41.2 µM 0.292695273050964 0.43097449929625 no 1430 0.384877541652286 446 24207482
SGTC_913 3487-1245 167 µM 0.292558044918009 0.431014599001955 no 1431 0.384929993262285 397 4016153
SGTC_560 2332-1943 155 µM 0.291916523424453 0.431202068700352 no 1432 0.385175224802077 417 21177716
SGTC_1754 st042065 16.137 µM 0.290866312058368 0.43150900192392 no 1433 0.385576783480014 419 1126236 YIL048W NEO1
SGTC_2698 st077697 67.5 µM 0.290686549002567 0.431561543359877 no 1434 0.385645529966279 412 3154499
SGTC_2296 7971656 126.45 µM 0.289305385907291 0.431965272261494 no 1435 0.38617384555405 411 666570
SGTC_965 1291-5240 308 µM 0.288606143005332 0.432169695642774 no 1436 0.386441397011548 412 2834598
SGTC_2598 perillyl alcohol 100 µM 0.288131406145098 0.432308495127188 no 1437 0.386623076458767 403 10819 An apoptosis inducer.
SGTC_37 0566-0070 1.56 µM 0.288129185014274 0.432309144541984 no 1438 0.386623926532983 445 1626686
SGTC_816 0325-0417 81.3 µM 0.287627102420273 0.432455948268418 no 1439 0.386816098220905 423 68101
SGTC_2816 7982706 58.44 µM 0.281851207162626 0.434145425599094 no 1440 0.389028802147095 403 2981853
SGTC_2307 7538926 6.34 µM 0.281441987873117 0.434265170243041 no 1441 0.389185708669597 409 96582
SGTC_996 3970-0799 1.8 µM 0.281165136170465 0.434346185262345 no 1442 0.389291871877818 415 6615648 YGL040C HEM2
SGTC_2502 avocadyne acetate 18.59 µM 0.280220685703182 0.434622580208049 no 1443 0.389654098636052 381 3952079
SGTC_1400 3771-8998 51.5 µM 0.280110904310738 0.434654709984532 no 1444 0.389696209513415 440 670767
SGTC_1465 k213-0056 144 µM 0.277505970261403 0.435417223521389 no 1445 0.390695811084426 403 24048857 YMR208W ERG12
SGTC_1713 st033146 12.748 µM 0.277498346623004 0.435419455458629 no 1446 0.390698737597036 422 674619
SGTC_31 0508-1974 57.237 µM 0.277305063391811 0.435476042780467 no 1447 0.390772935971666 413 6810525
SGTC_428 3448-4153 16.5 µM 0.276869254143028 0.435603639027714 no 1448 0.390940250836855 385 3834874
SGTC_2435 5706476 10.6 µM 0.275188593482951 0.43609576557797 no 1449 0.391585674936671 413 5725375
SGTC_2235 salicylic acid 500 µM 0.274735503116405 0.436228455250767 no 1450 0.391759726393626 406 338 A COX inhibitor and kinase inhibitor.
SGTC_1355 1499-0035 1.68 µM 0.273807187584998 0.436500339278651 no 1451 0.392116399871496 421 1548538
SGTC_924 2046-0044 21.3 µM 0.273726458699257 0.4365239844854 no 1452 0.392147421472886 400 3623589
SGTC_983 1491-0821 12.2 µM 0.273646350982764 0.436547447978064 no 1453 0.392178205055862 396 46495113
SGTC_808 0711-0032 135 µM 0.273554527959039 0.43657434315042 no 1454 0.392213491396402 432 4252555
SGTC_1908 st060353 56.5 µM 0.272878632002247 0.436772323626904 no 1455 0.392473256286618 422 4227716
SGTC_3074 9116018 49.47 µM 0.272426563061008 0.436904750518699 no 1456 0.392647025217376 427 17027303
SGTC_2992 9074591 71.4286 µM 0.270789808767993 0.437384272450138 no 1457 0.393276349282113 413 17741321
SGTC_1654 st012436 41.8 µM 0.270438390154369 0.437487240015996 no 1458 0.393411504463612 443 4323132
SGTC_708 3448-5400 146 µM 0.269352544983125 0.437805425281107 no 1459 0.393829200324414 434 3462195
SGTC_1087 pterostilbene 9.05 µM 0.267118635040744 0.438460154286164 no 1460 0.394688910024733 419 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.262430442853816 0.439834746124033 no 1461 0.396494802442545 446 6728940
SGTC_1863 st057641 20.1 µM 0.260054287830225 0.440531719944791 no 1462 0.39741094903275 452 3921635
SGTC_1649 st011737 51.3 µM 0.258834808895121 0.440889489213816 no 1463 0.397881349606497 437 1761035
SGTC_898 1000-0849 28.3 µM 0.256906233098242 0.44145539085095 no 1464 0.398625579363058 450 6751807
SGTC_1389 3405-0187 19 µM 0.255764908212143 0.441790345978077 no 1465 0.399066186001494 442 799890
SGTC_862 0452-0056 10.2 µM 0.254279836020679 0.442226246083433 no 1466 0.399639688239871 419 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3116 9124943 49.47 µM 0.25418409478467 0.442254350567815 no 1467 0.399676668845915 401 41905195 YPL160W CDC60
SGTC_3259 9138485 49.47 µM 0.253829722018632 0.442358377905359 no 1468 0.399813555203875 401 17646153
SGTC_1495 4469-0029 237 µM 0.252294451848634 0.442809107536141 no 1469 0.400406738123364 430 793680
SGTC_3330 9141424 71.43 µM 0.251966042136926 0.442905532762895 no 1470 0.400533655789972 404 27261020
SGTC_2285 7945142 200 µM 0.250608478311523 0.443304166417266 no 1471 0.401058413063137 444 2970608
SGTC_2626 ethyl orsellinate 100 µM 0.247730637259748 0.444149402005929 no 1472 0.402171412745723 422 75653 A natural product.
SGTC_8 0354-0001 70 µM 0.246743364311623 0.444439427490774 no 1473 0.402553422027354 434 4993152
SGTC_2063 5246145 200 µM 0.246003742375832 0.444656721466496 no 1474 0.402839667757878 443 711240
SGTC_133 0724-0033 378.92 µM 0.245905108485619 0.444685700435139 no 1475 0.40287784461866 466 280309
SGTC_2465 5809242 33.21 µM 0.244966342034098 0.444961527952092 no 1476 0.403241246310857 447 2731748
SGTC_2920 7982904 15.77 µM 0.244538101888293 0.445087361947223 no 1477 0.403407048220617 426 6456808
SGTC_2733 amorolfine 100 µM 0.243110816893562 0.445506794955966 no 1478 0.403959775943727 459 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2120 5538279 151.968 µM 0.239250973222595 0.446641382704195 no 1479 0.405455489596974 423 2058197
SGTC_3194 9111903 49.47 µM 0.23918818745031 0.446659842002172 no 1480 0.405479830956818 454 17087251
SGTC_952 1185-0122 232 µM 0.239130712749982 0.446676739922556 no 1481 0.405502113592408 447 678600
SGTC_1800 st050079 29.0735 µM 0.237726998546077 0.447089470639066 no 1482 0.406046421032883 449 3645560
SGTC_3131 9127911 49.47 µM 0.236809802082905 0.447359182698001 no 1483 0.406402173432324 417 45595681
SGTC_2175 5807670 165.306 µM 0.236178039233028 0.447544973921357 no 1484 0.406647259844233 429 241186
SGTC_3150 9097574 49.47 µM 0.234535667190226 0.448028022697086 no 1485 0.407284573404548 453 17217476
SGTC_2591 skatole 100 µM 0.234183589848826 0.448131584522169 no 1486 0.407421227121909 448 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_422 cantharidin 155 µM 0.233999116400395 0.448185847895118 no 1487 0.407492832316883 423 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2635 hydroquinidine 100 µM 0.233939228999929 0.448203464147424 no 1488 0.407516078868883 423 442912 An experimental heart treatment.
SGTC_303 1348-1668 34.2 µM 0.233487423007782 0.448336368987207 no 1489 0.407691467343064 434 5380509
SGTC_1280 0880-0253 10.1 µM 0.232900362902739 0.448509069313104 no 1490 0.407919388317505 455 6836607
SGTC_2868 9035608 32.47 µM 0.232191061000056 0.448717743534166 no 1491 0.408194810173368 432 6462614
SGTC_2132 5317594 122.667 µM 0.231739857025181 0.44885049360462 no 1492 0.408370036245574 448 794577
SGTC_3353 9151644 39.2805 µM 0.23040223693057 0.449244072407889 no 1493 0.408889611545497 470 4909158
SGTC_2854 9024559 71.43 µM 0.228710641826985 0.449741875618884 no 1494 0.409546911512761 428 3163529
SGTC_176 1486-1328 72.834 µM 0.227229455302717 0.450177824699938 no 1495 0.410122662330938 411 22310231
SGTC_1626 st003712 1.76 µM 0.226322919009185 0.45044466998978 no 1496 0.410475137007865 452 24207035
SGTC_3105 9121040 49.47 µM 0.224632400908285 0.450942345551834 no 1497 0.411132628349742 455 41448907
SGTC_1204 4049-0315 18.3 µM 0.224439907046843 0.450999019174205 no 1498 0.411207510645264 410 588402
SGTC_464 bw-b 70c 158 µM 0.224364676185682 0.451021168751639 no 1499 0.411236777183009 462 5353454
SGTC_216 k038-0035 28.382 µM 0.223920680624229 0.451151893661914 no 1500 0.411409511738443 441 4444231 YPR107C YTH1
SGTC_157 1348-1695 65.819 µM 0.221558812375004 0.45184738350677 no 1501 0.41232867427068 442 5380510
SGTC_1512 0259-0544 12.2 µM 0.219905932673272 0.452334188387491 no 1502 0.412972207901373 438 18476
SGTC_693 4161-2696 114 µM 0.219711405247827 0.452391485185359 no 1503 0.413047960799124 459 805759
SGTC_1555 citronellol 128 µM 0.21969438377101 0.452396498798704 no 1504 0.413054589459141 470 8842 A terpine precursor.
SGTC_736 0958-0254 92.6 µM 0.219581142385208 0.452429853825273 no 1505 0.413098689591805 465 6812352
SGTC_441 propafenone 146 µM 0.219470434061162 0.452462463068044 no 1506 0.413141804322233 462 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1847 st056231 15 µM 0.218966056328559 0.452611032066689 no 1507 0.413338244627271 413 5393180
SGTC_480 am 92016 50 µM 0.218432748585332 0.452768129876494 no 1508 0.413545975919066 462 2129 K+ channel blocker.
SGTC_1990 st072050 59.8 µM 0.217175364501087 0.453138549905906 no 1509 0.414035841397066 423 17233948
SGTC_609 0986-0026 86.3 µM 0.213984210023169 0.45407883285487 no 1510 0.415279685287571 454 2848610
SGTC_1903 st060211 78.3 µM 0.211491626778908 0.45481345910001 no 1511 0.416251832657237 433 688960
SGTC_828 2074-0507 139 µM 0.210179575140486 0.455200215590129 no 1512 0.416763760099272 458 X828
SGTC_2419 paclitaxel 166.5 µM 0.208788986564056 0.455610168942153 no 1513 0.417306484656736 439 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_553 k007-0256 45.7 µM 0.208220702150858 0.455777716021386 no 1514 0.417528322424686 445 6287000
SGTC_2969 9091408 28.7 µM 0.207139274318004 0.456096574680506 no 1515 0.417950545355165 424 4286311
SGTC_1037 k284-1091 78.7 µM 0.206113363769649 0.456399090225604 no 1516 0.418351180056965 462 3334711
SGTC_2653 dihydrofissinolide 100 µM 0.205197960496201 0.456669041261962 no 1517 0.418708731415431 445 6857746
SGTC_2655 perillic acid 100 µM 0.204267007168397 0.456943598496535 no 1518 0.419072425425343 454 5702197 An apoptosis inducer.
SGTC_895 0964-0006 13.7 µM 0.204237531247876 0.456952291886568 no 1519 0.419083941866136 461 6738897
SGTC_945 3381-0768 11.3 µM 0.204052287088127 0.457006926774933 no 1520 0.419156319594357 479 1126236 YIL048W NEO1
SGTC_1529 apigenin 74 µM 0.202734322561767 0.457395663344455 no 1521 0.41967134734252 466 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2935 9038016 29.96 µM 0.202019074415385 0.457606644465208 no 1522 0.41995090619187 471 6463195
SGTC_2056 5235370 200 µM 0.200648932365428 0.458010836960391 no 1523 0.420486546784933 429 5511916
SGTC_912 3474-0017 2.18 µM 0.199559873404871 0.458332140820585 no 1524 0.420912406419955 465 3360550
SGTC_3298 9116858 71.43 µM 0.198248131413443 0.458719178738697 no 1525 0.421425465648696 462 2506942
SGTC_1887 st057648 70.8 µM 0.196802008414189 0.459145911980417 no 1526 0.421991239683821 465 688672
SGTC_2617 dihydrotanshinone i 20.83 µM 0.195233498139015 0.459608813421074 no 1527 0.422605077939978 442 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_756 0508-1999 28.3 µM 0.193837313313561 0.460020903965952 no 1528 0.423151634636832 436 6753853
SGTC_836 0330-0104 1.35 µM 0.192895088831492 0.460299030271313 no 1529 0.423520565674652 421 46494820
SGTC_2259 7964009 200 µM 0.19185639261018 0.460605655659426 no 1530 0.423927348230973 427 313134
SGTC_1337 1486-1011 40.3 µM 0.190331302656291 0.461055907934917 no 1531 0.424524762993983 450 X1337
SGTC_1897 st060201 15 µM 0.190329862561677 0.461056333117706 no 1532 0.424525327196182 443 611878
SGTC_77 0828-0286 12.516 µM 0.189957343294382 0.461166319593963 no 1533 0.4246712784849 427 745345
SGTC_2804 7954240 19.48 µM 0.186876540084278 0.462076041178272 no 1534 0.425878716725691 443 828705
SGTC_648 0375-0473 33.3 µM 0.186836584741251 0.462087840791156 no 1535 0.425894380742915 462 1713139
SGTC_150 3970-0969 77.2 µM 0.186835429154309 0.462088182059617 no 1536 0.425894833778777 450 6615640
SGTC_9 0092-0002 10.449 µM 0.185789285810967 0.462397141005815 no 1537 0.426305003468014 455 759368
SGTC_704 1310-0270 142 µM 0.184605551240034 0.462746762309182 no 1538 0.426769215762521 469 5718033
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.182372141072229 0.463406488160856 no 1539 0.427645343682138 433 2724 A muscle relaxant with antifungal properties.
SGTC_1046 2001-0062 216 µM 0.179803096404864 0.464165481275185 no 1540 0.428653576328543 471 739778
SGTC_1365 1672-3266 55.4 µM 0.1776206233984 0.464810369051685 no 1541 0.429510463478586 478 6415873
SGTC_2511 berberine 10.47 µM 0.17727410923485 0.464912767295529 no 1542 0.429646543264097 438 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_252 miconazole 1.30953 nM 0.175503215186304 0.465436119533257 no 1543 0.430342122318399 473 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2220 6782180 200 µM 0.175004913987943 0.465583393281398 no 1544 0.430537886185527 480 833803
SGTC_1353 1498-1206 8.11 µM 0.174430411662063 0.465753194248473 no 1545 0.430763607805146 474 6756808
SGTC_1340 1486-1359 257 µM 0.174370678345709 0.465770849495996 no 1546 0.430787078288853 464 4309068
SGTC_2832 7992762 51.95 µM 0.174315025905222 0.465787298628461 no 1547 0.430808945530081 410 2985177
SGTC_3101 9120531 49.47 µM 0.171648254807542 0.466575581310832 no 1548 0.431857034282009 494 24824904
SGTC_2279 7948423 32.93 µM 0.170498280706586 0.466915547896353 no 1549 0.432309143182919 410 1247112
SGTC_2265 7929201 200 µM 0.168968479705112 0.467367839994775 no 1550 0.432910717212895 487 1265108
SGTC_834 0312-0008 75.7 µM 0.168758888943979 0.467429809679418 no 1551 0.432993148154059 454 6385573 YIL048W NEO1
SGTC_1384 3089-0840 101 µM 0.168301247112071 0.467565123347162 no 1552 0.433173146402178 448 1069836
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.167929664740467 0.467674994062977 no 1553 0.433319306213999 461 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1791 st048313 56.1 µM 0.16444191854726 0.468706381398787 no 1554 0.434691633233026 479 1204976
SGTC_1155 4088-0394 48.2 µM 0.163993054452783 0.468839133737095 no 1555 0.434868305766242 459 2326248
SGTC_1049 3226-0134 66 µM 0.161273814767444 0.46964342715368 no 1556 0.435938873032751 474 5702385
SGTC_1511 0906-3109 28.5 µM 0.160127646232836 0.469982476794904 no 1557 0.436390261809514 448 2882180
SGTC_1194 1488-0194 225 µM 0.158968299276712 0.470325446903038 no 1558 0.436846924850706 464 1391452
SGTC_3173 9105693 49.47 µM 0.158369587847947 0.470502572598162 no 1559 0.43708278835415 463 17096658
SGTC_1062 mesoridazine 14.2 µM 0.156641004166504 0.471013997810886 no 1560 0.437763892385554 474 4078 A neuroleptic.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.15532288848837 0.471404012601968 no 1561 0.43828338608976 496 688667
SGTC_412 gemfibrozil 100 µM 0.154663810742571 0.471599036196263 no 1562 0.438543180732386 487 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3336 9143619 71.43 µM 0.15415983665447 0.471748168629792 no 1563 0.43874185463595 494 45595730
SGTC_939 1165-0479 45.3 µM 0.152347000545058 0.472284642821612 no 1564 0.43945662822733 477 1377347
SGTC_2035 5154463 94.595 µM 0.151451613569579 0.472549634092703 no 1565 0.439809738619622 499 2769623
SGTC_787 4152-0075 138 µM 0.151422117527413 0.472558363703015 no 1566 0.439821371679046 477 9566539
SGTC_1054 3429-0080 167 µM 0.150488900839984 0.472834564084874 no 1567 0.440189453432783 480 1162877
SGTC_3053 9095903 49.47 µM 0.148634060308324 0.473383572413493 no 1568 0.440921197642782 493 17174018
SGTC_178 4092-0806 87.505 µM 0.148201701057842 0.473511552352703 no 1569 0.441091794696795 470 2169044
SGTC_1108 betulinic acid 729.144 nM 0.14746665403144 0.473729135262579 no 1570 0.441381849085141 440 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1256 0570-0116 285 µM 0.147306239820493 0.473776620875074 no 1571 0.441445153772215 456 410638
SGTC_3054 9094397 49.47 µM 0.147006943832147 0.473865219091847 no 1572 0.441563269742776 467 2598354
SGTC_1096 rimcazole 32.2 µM 0.146985080492701 0.473871691173474 no 1573 0.441571898226481 495 18528119 A dopamine reuptake inhibitor.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.146766785780859 0.473936312109331 no 1574 0.44165805092052 460 115019
SGTC_2244 6635614 200 µM 0.146046000025036 0.474149688379167 no 1575 0.441942537469844 453 836499
SGTC_764 1951-2361 146 µM 0.146029812852575 0.474154480399522 no 1576 0.441948926720778 470 5438930
SGTC_2325 6158266 200 µM 0.144762662456012 0.474529616789346 no 1577 0.442449131335679 459 3623240
SGTC_3 0833-0587 95.581 µM 0.14474933738617 0.474533561760199 no 1578 0.442454391864345 463 5382644
SGTC_2138 5575593 77.673 µM 0.144387014281295 0.474640830753177 no 1579 0.442597435231535 484 762213
SGTC_3289 9119912 71.43 µM 0.142765689869042 0.47512086074309 no 1580 0.443237617485567 479 17014829
SGTC_2962 9082311 13.18 µM 0.142124859747741 0.475310603081787 no 1581 0.443490691127776 478 16459453
SGTC_2924 9010168 62.78 µM 0.141891264604318 0.475379769279175 no 1582 0.443582947170107 463 2993929
SGTC_2690 usnic acid 100 µM 0.14174088643162 0.475424295796087 no 1583 0.443642339128635 481 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_339 3091-4833 71.4 µM 0.140995054650139 0.475645138830227 no 1584 0.443936924566707 478 3240077
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.140034345891147 0.4759296186004 no 1585 0.444316426822629 470 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2722 naftopidil 47.16 µM 0.139074290386837 0.476213917189784 no 1586 0.444695722034516 491 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_921 1561-0023 372 µM 0.137283556855322 0.476744234418584 no 1587 0.445403333550811 492 24050882
SGTC_2849 9019321 12.99 µM 0.136909629616646 0.47685497642383 no 1588 0.445551113590899 493 16489627
SGTC_3024 9090631 49.47 µM 0.136397802424869 0.477006561669961 no 1589 0.445753405427221 490 25236383
SGTC_302 1094-0063 18.9 µM 0.135627353538263 0.477234747849669 no 1590 0.446057940129802 490 5440289
SGTC_959 1222-0044 107 µM 0.135087045060151 0.477394777104973 no 1591 0.446271526415901 477 6083612
SGTC_129 0088-0017 176.636 µM 0.135038150307833 0.477409258995427 no 1592 0.446290855493824 492 182446
SGTC_2975 9084847 53.72 µM 0.134726377082311 0.477501602237781 no 1593 0.44641410871311 452 27211724
SGTC_1346 1488-2224 62.4 µM 0.134410288216432 0.4775952249508 no 1594 0.446539073318436 479 3722427
SGTC_1709 st033179 39.1045 µM 0.133968878038989 0.477725968790533 no 1595 0.446713592138546 481 573381
SGTC_967 1306-0166 352 µM 0.133106575843076 0.477981385980717 no 1596 0.447054547327733 503 4437607
SGTC_1144 3486-0183 12.5 µM 0.131746744575485 0.478384191510356 no 1597 0.447592305456353 503 6744069
SGTC_1026 k007-1105 30.6 µM 0.130999854989806 0.478605442538434 no 1598 0.447887711058898 460 7066794
SGTC_1956 st077085 54 µM 0.130954275946479 0.478618944628073 no 1599 0.447905739165277 500 24208685
SGTC_446 go6976 132 µM 0.129445673795663 0.47906585853558 no 1600 0.448502504600265 495 3501 A protein kinase C inhibitor.
SGTC_2971 9092186 9.93 µM 0.129305000411621 0.479107533491916 no 1601 0.448558157448362 440 25236400
SGTC_1078 idebenone 36.1 µM 0.128805378904299 0.479255549862735 no 1602 0.448755824619407 509 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_549 1661-1316 519 µM 0.128456117361338 0.479359022741173 no 1603 0.448894011859172 488 2857282
SGTC_3204 9114183 49.47 µM 0.127518053544878 0.479636942149345 no 1604 0.449265192581065 457 17027248
SGTC_1699 st031318 29.054 µM 0.12283972447433 0.481023132045748 no 1605 0.451117008437999 494 5340658
SGTC_2395 5646831 180.19 µM 0.119325193170989 0.482064640292482 no 1606 0.452508862412823 489 6808628
SGTC_1692 fluoroquinolonic acid 71 µM 0.119048980978053 0.482146499241078 no 1607 0.452618275232861 496 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2349 9023730 187.07 µM 0.117444057911265 0.482622153109997 no 1608 0.453254086228332 476 4126287
SGTC_2684 capsaicin 100 µM 0.117114437866901 0.482719846265659 no 1609 0.453384684353568 488 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2390 9097792 176.6 µM 0.115411780048591 0.483224498277404 no 1610 0.454059371113693 447 4497149
SGTC_2719 novobiocin 32.65 µM 0.11492825102531 0.483367816737897 no 1611 0.454250996189253 472 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_722 3534-0461 190 µM 0.112944450624979 0.483955839350712 no 1612 0.455037297634506 471 658262
SGTC_361 000s-0510 1.45 µM 0.112518440654613 0.484082118492326 no 1613 0.455206174530011 477 660
SGTC_2020 4017018 200 µM 0.111871108442564 0.48427400568271 no 1614 0.455462802447474 488 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2862 9027634 71.43 µM 0.111784200819045 0.48429976778682 no 1615 0.455497257460753 495 5012562
SGTC_2478 5763493 32.33 µM 0.111221786715183 0.484466486279355 no 1616 0.455720237757719 484 1365576 YLR208W SEC13
SGTC_1012 4112-3522 18 µM 0.110727454322985 0.484613025301702 no 1617 0.45591623722145 478 3112398
SGTC_2314 7727897 200 µM 0.107432664102901 0.485589779234156 no 1618 0.457222871123675 497 900724
SGTC_3301 9125354 19.7965 µM 0.106460009082752 0.485878143555579 no 1619 0.457608691584905 466 41905162
SGTC_2287 7945887 168.79 µM 0.102632407462674 0.487012987952057 no 1620 0.459127360604694 501 1245853
SGTC_1921 5740136 50 µM 0.102476946152255 0.487059082911615 no 1621 0.459189055403424 510 1774243
SGTC_1318 1280-3875 124 µM 0.102028577161922 0.487192027247576 no 1622 0.459366996072942 483 373245
SGTC_1953 st076800 12.1 µM 0.101938211520527 0.48721882142365 no 1623 0.459402859760042 472 297591
SGTC_167 3672-0051 66.205 µM 0.101449555553854 0.487363713042332 no 1624 0.459596799856689 500 3237971
SGTC_1398 3558-0053 112 µM 0.100675602068268 0.487593201772633 no 1625 0.459903989840302 488 4532369
SGTC_2021 4019055 173 µM 0.100161786746776 0.487745557938314 no 1626 0.460107941581478 503 44827708 YER133W GLC7
SGTC_1596 piperlongumine 63 µM 0.0994059452939921 0.487969682770078 no 1627 0.460407981242377 463 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1896 st058441 89 µM 0.0985509774105371 0.488223205504023 no 1628 0.460747397405313 448 688759
SGTC_1505 k297-0037 20.6 µM 0.0978674456063597 0.488425895904437 no 1629 0.461018775249646 466 4089396
SGTC_1416 3966-0321 25.3 µM 0.0967935794395435 0.488744339720923 no 1630 0.461445161429145 492 582530 YLR208W SEC13
SGTC_2565 isoliquiritigenin 100 µM 0.0966969816808764 0.488772985133985 no 1631 0.461483518434515 502 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2570 licareol 100 µM 0.0961256303500813 0.488942416692483 no 1632 0.461710397742717 488 443158
SGTC_1763 st044482 94.5 µM 0.0958960713908622 0.489010491889272 no 1633 0.461801557388827 518 88505
SGTC_2792 7535235 81.82 µM 0.0954612264558293 0.489139445059816 no 1634 0.461974243187989 487 1281891
SGTC_2821 7996764 71.43 µM 0.0952930802354045 0.489189309089889 no 1635 0.462041019407744 489 2987135
SGTC_782 0083-0095 30.5 µM 0.0946300057394952 0.489385946529654 no 1636 0.462304357820892 474 3591729 An indicator and reagent.
SGTC_2767 sibutramine 71.45 µM 0.0939450012841152 0.489589090096885 no 1637 0.462576423015383 504 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2759 disulfiram 3.38 µM 0.0938573351800831 0.489615088379445 no 1638 0.462611242881084 498 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1218 1348-1416 30.7 µM 0.0933010758209519 0.489780053822973 no 1639 0.462832188715626 499 6787668
SGTC_1319 1306-0155 43.7 µM 0.0927631623294851 0.489939580240495 no 1640 0.463045858491102 505 3122360
SGTC_1295 1013-0063 9.78 µM 0.0905331372626324 0.490600944931521 no 1641 0.463931781168094 498 6826038
SGTC_345 1362-0200 395 µM 0.0897454348872749 0.490834562269566 no 1642 0.464244754885784 480 1419823
SGTC_2621 lithochol-11-enic acid 100 µM 0.0893421967681801 0.49095415614326 no 1643 0.464404979980141 503 6708711
SGTC_2556 citropten 84.59 µM 0.0881104416757964 0.491319479678636 no 1644 0.464894448701075 489 2775 A potential DNA crosslinker.
SGTC_401 neomycin 50 µM 0.0879381721557894 0.491370573304323 no 1645 0.464962908558701 471 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_95 0471-0001 561.058 µM 0.0869950562518797 0.491650295680358 no 1646 0.465337720874907 516 4015405
SGTC_714 4296-0578 26.1 µM 0.0868195249812695 0.491702357632891 no 1647 0.465407483766832 506 1589775
SGTC_83 0170-0301 39.027 µM 0.0845326555112431 0.492380647602006 no 1648 0.466316470202585 508 3089716
SGTC_788 1182-0090 188 µM 0.0843238297183162 0.492442586869037 no 1649 0.46639948324879 464 5715185
SGTC_3217 9129673 49.47 µM 0.083952953897985 0.492552591815034 no 1650 0.466546918501851 482 17248312
SGTC_408 cantharidin 100 µM 0.0836290195183108 0.492648673991215 no 1651 0.46667569675548 482 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1900 st060200 72.8 µM 0.0816875794802505 0.493224533263684 no 1652 0.467447577743804 488 688945
SGTC_1852 st056254 31.4 µM 0.0810120141713131 0.493424919104983 no 1653 0.467716198992029 509 442583
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0791547040037837 0.49397584190971 no 1654 0.468454786231275 504 66535 A nucleotide analog.
SGTC_2201 6605497 169.863 µM 0.0787720036903832 0.494089361476663 no 1655 0.468606986325796 507 670741
SGTC_2900 5328528 85.29 µM 0.0781330845141738 0.494278883753252 no 1656 0.468861094995912 521 795359
SGTC_2356 9061756 188.97 µM 0.0779329734300168 0.494338242871922 no 1657 0.468940685080648 496 20104043
SGTC_2371 9071574 200 µM 0.0773703690621363 0.494505129344687 no 1658 0.469164456083989 515 45596039
SGTC_2229 7354935 190 µM 0.0746431463664585 0.495314124033896 no 1659 0.470249322009986 513 318112
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.073806229800888 0.495562388327554 no 1660 0.47058228494197 496 5282362
SGTC_2880 9042983 58.44 µM 0.0725335761080686 0.495939913654507 no 1661 0.471088642979777 507 6464714
SGTC_3283 9109332 35.8195 µM 0.0702032447568023 0.496631202098322 no 1662 0.472015945878671 521 17027281
SGTC_1784 st039334 36.3 µM 0.0701797510238612 0.496638171525322 no 1663 0.472025295461694 526 3496984
SGTC_601 0986-0029 62.9 µM 0.0695683698829793 0.496819538384754 no 1664 0.472268606549744 524 24747981
SGTC_2333 9017922 200 µM 0.0693150097620875 0.496894698126287 no 1665 0.472369439205537 527 3163164
SGTC_2198 6589944 200 µM 0.0692744750218099 0.49690672284115 no 1666 0.472385571449134 511 5290268
SGTC_2383 9036125 200 µM 0.069233779106005 0.496918795371895 no 1667 0.472401767883843 524 79580
SGTC_2787 5284540 71.43 µM 0.0689739391484925 0.496995877518885 no 1668 0.472505181815212 517 736958
SGTC_335 4077-0256 27.6 µM 0.0686110323237988 0.497103534886451 no 1669 0.472649618519405 511 3121989
SGTC_330 1488-0319 80.1 µM 0.0682286677811089 0.497216964670839 no 1670 0.47280180327447 528 6846614
SGTC_2761 levamisole 97.89 µM 0.0678909464328014 0.497317151082254 no 1671 0.47293622291275 519 26879 An alkaline phosphatase inhibitor.
SGTC_536 3852-0578 10.6 µM 0.0658804021482718 0.497913590506827 no 1672 0.473736521750518 482 2869208
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0657297992152399 0.497958267929835 no 1673 0.473796473682112 519 5024745
SGTC_902 1120-0002 2.07 µM 0.0654480866243183 0.498041840026513 no 1674 0.473908619265498 505 3280475
SGTC_3121 9125696 49.47 µM 0.0623990707219 0.498946357582423 no 1675 0.475122517488055 531 1235365
SGTC_3346 9158254 43.5805 µM 0.0621877188221648 0.49900905724847 no 1676 0.475206671260276 519 17639500
SGTC_1000 4048-0884 8.67 µM 0.0599264162977021 0.499679896596659 no 1677 0.476107120267906 517 13040088
SGTC_2927 9011802 47.9 µM 0.059130364111449 0.499916054223311 no 1678 0.476424136941372 509 43912568
SGTC_1840 st055363 71 µM 0.0585644267673378 0.499916054223311 no 1679 0.476649522677732 496 676033
SGTC_3212 9128307 49.47 µM 0.0579265272641575 0.499726814321295 no 1680 0.476903576446966 484 27243542
SGTC_2164 5685496 200 µM 0.057458653490159 0.499588014458131 no 1681 0.477089920700048 507 759046
SGTC_3155 9099265 49.47 µM 0.0553392492536446 0.498959270924553 no 1682 0.477934096837961 523 25236499
SGTC_13 0199-0087 65 µM 0.0520632376874256 0.497987413320054 no 1683 0.479239152647393 526 4589825
SGTC_1606 st000094 49.2 µM 0.0511904485591786 0.497728494536393 no 1684 0.479586881406475 525 1242210
SGTC_311 1315-0136 58 µM 0.0497843281903214 0.497311361500976 no 1685 0.480147127744305 516 6759207
SGTC_3327 9140648 26.9345 µM 0.0487979069702113 0.497018736162424 no 1686 0.480540175092514 526 8029710
SGTC_1725 st036284 20.55 µM 0.0475522745756688 0.496649217224959 no 1687 0.481036534169318 488 707914
SGTC_73 0327-0325 16.231 µM 0.0471365105275901 0.496525880747546 no 1688 0.481202214236252 530 53298
SGTC_1223 0764-0573 147 µM 0.0466368789159192 0.496377665383109 no 1689 0.481401319435714 527 1609797
SGTC_228 caffeine 993.056 µM 0.0459956177204166 0.496187436438274 no 1690 0.48165687138359 511 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2179 6298986 200 µM 0.0458648418401192 0.49614864212084 no 1691 0.481708988409783 527 738374
SGTC_738 1315-0003 72.4 µM 0.0447753912524864 0.495825460948928 no 1692 0.482143170175338 527 6251474
SGTC_1314 1222-0010 41.1 µM 0.0436564109192677 0.495493522749886 no 1693 0.482589142556569 522 3526027
SGTC_846 0335-0850 148 µM 0.0423812739307142 0.495115265516723 no 1694 0.483097378086941 517 6819598
SGTC_277 nystatin 15.5 µM 0.0421315242993697 0.49504118017282 no 1695 0.483196924858934 510 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1539 benzyladenosine 56 µM 0.0419282039646965 0.494980867669759 no 1696 0.483277966324881 512 92208 A nucleotide analog.
SGTC_3210 9128157 49.47 µM 0.0417362773407208 0.494923935077567 no 1697 0.48335446700485 498 17590849
SGTC_645 0845-0943 5.41 µM 0.0401725629213626 0.494460083037129 no 1698 0.483977775791645 525 1885106
SGTC_1581 himbacine 57.9 µM 0.0390175823894955 0.494117480446634 no 1699 0.484438185283741 513 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2113 5491891 107.031 µM 0.0375610584275155 0.493685437059071 no 1700 0.485018828434915 524 789979
SGTC_1329 1447-1697 50.6 µM 0.0358324263602153 0.493172688890115 no 1701 0.485707988582748 515 2840515
SGTC_802 4112-3352 742 µM 0.0322720449550682 0.492116642313593 no 1702 0.487127551241319 521 704594
SGTC_1666 st014829 29 µM 0.0314634527348069 0.49187681278882 no 1703 0.487449969098955 516 3858230
SGTC_1474 0330-0125 5.35 µM 0.030769709826098 0.491671050059348 no 1704 0.487726598516941 533 X1474
SGTC_940 3232-1287 54.8 µM 0.0298809245356228 0.49140744140391 no 1705 0.488081009535787 532 1585493 YIL048W NEO1
SGTC_757 1066-0008 322 µM 0.0290065084109752 0.491148098222853 no 1706 0.488429699909208 506 6842497
SGTC_859 0439-0102 54.6 µM 0.0289133036831598 0.491120454840452 no 1707 0.488466867626746 517 610143
SGTC_2036 5160441 105 µM 0.0283288802142038 0.490947122964316 no 1708 0.488699923379525 531 134534 YIL048W NEO1
SGTC_3062 9077494 49.47 µM 0.0275160133666893 0.490706040807472 no 1709 0.48902408393178 526 16459633
SGTC_1397 3532-0190 20.1 µM 0.0273377559803504 0.490653173220578 no 1710 0.489095171597582 528 5322280
SGTC_147 4466-0538 29.23 µM 0.0273216014005596 0.490648382102385 no 1711 0.489101613936105 515 6742687 YHR072W ERG7
SGTC_659 k018-0002 107 µM 0.0257667965479187 0.490187265177572 no 1712 0.489721672783653 528 6797879 YHR007C ERG11
SGTC_2612 dictamnine 15.46 µM 0.0245488009570655 0.489826046735751 no 1713 0.490207428946703 536 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_568 1193-0097 7.48 µM 0.0235763238727158 0.489537647187833 no 1714 0.49059527885695 529 3646150
SGTC_3203 9113543 49.47 µM 0.0225502577968985 0.489233361125989 no 1715 0.491004511126187 529 17018012
SGTC_3000 9075062 71.4286 µM 0.0214414801484805 0.488904553500103 no 1716 0.491446742394337 536 17057871
SGTC_919 tnp00227 403.569 nM 0.0202795444710065 0.488559989974878 no 1717 0.491910186789696 534 1269246 A methoxyflavone. YNL221C POP1
SGTC_1041 0206-0046 107 µM 0.0178205123933605 0.487830810471964 no 1718 0.492891020417087 537 50494
SGTC_2122 5258151 111.688 µM 0.0175766380253703 0.487758496313057 no 1719 0.492988296976717 527 2173356
SGTC_2094 5332512 191.667 µM 0.0157448848116678 0.487215353888539 no 1720 0.493718959262777 542 755774
SGTC_2123 5259487 200 µM 0.0136395108676852 0.486591108147114 no 1721 0.494558791141763 541 2173474
SGTC_2930 9013230 14.89 µM 0.0133635048490453 0.486509274455291 no 1722 0.494668891576294 539 2995857
SGTC_1246 0422-0085 105 µM 0.0133510548014296 0.486505583123934 no 1723 0.494673857983615 544 264295
SGTC_1671 st016596 74.5 µM 0.0119395212952745 0.486087083230148 no 1724 0.495236933312078 544 2829167
SGTC_628 1636-0253 16 µM 0.00916055849405236 0.485263204934963 no 1725 0.4963455170162 539 4456143
SGTC_2261 9010538 184.68 µM 0.00903270873401152 0.485225302840362 no 1726 0.496396519580742 542 6457250
SGTC_2326 6164455 177.58 µM 0.00783882270711952 0.484871372168164 no 1727 0.496872794219901 542 2888790
SGTC_2477 5967686 25.23 µM 0.00454780347201176 0.483895803359501 no 1728 0.498185695166125 544 776118
SGTC_1113 artemisinin 1.17947 µM 0.0041464735138635 0.483776842137119 no 1729 0.49834580114093 543 2240 An anti-malaria and mitochondrial poison.
SGTC_2531 methyl deoxycholate 70.07 µM 0.00400005420222367 0.483733441249971 no 1730 0.498404213510383 545 16667744 Haematoxylin.
SGTC_2904 7225135 42.03 µM 0.00307633127102923 0.483459640338154 no 1731 0.498772723323252 543 4446116
SGTC_1289 0976-0073 69.1 µM 0.00225877841546321 0.483217315823606 no 1732 0.499098878554279 547 3391136
SGTC_1859 st055998 20 µM 0.00206732851251841 0.483160570532109 no 1733 0.499175255836349 540 676301
SGTC_1105 epirubicin 18.1 µM 0.0013390516359778 0.482944714141251 no 1734 0.499465795846411 546 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1177 0983-0204 23.6 µM 0.000313991992175108 0.482640901809413 no 1735 0.499874735320672 547 766818
SGTC_554 4483-2211 187 µM -0.0002711393653958 0.482467482143095 no 1736 0.499891831044588 548 747107
SGTC_3030 9087619 49.47 µM -0.000919958509571704 0.482275190740798 no 1737 0.499632989706085 548 25236973
SGTC_2353 9059630 146.67 µM -0.00278821402626069 0.481721516527442 no 1738 0.498887664979357 551 4779114
SGTC_2025 5147754 141 µM -0.00356183533863584 0.481492257200633 no 1739 0.498579036292141 549 315777 YLR208W SEC13
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0039998769719666 0.481362448168083 no 1740 0.49840428421446 554 442882
SGTC_583 1488-1091 88.9 µM -0.00435089392119168 0.481258429411251 no 1741 0.498264249933669 554 4303273
SGTC_2078 5212016 200 µM -0.00454737057921663 0.481200206973828 no 1742 0.498185867863578 551 1899708
SGTC_402 epigallocatechin gallate 10 µM -0.0067772643183419 0.480539445183478 no 1743 0.497296283415515 557 65064 An antioxidant.
SGTC_352 k048-0007 5.11 µM -0.00714103682068908 0.480431657192749 no 1744 0.497151162698806 552 6811911
SGTC_1477 0139-0234 16 µM -0.00789368846484664 0.480208646513749 no 1745 0.496850906626591 553 620880
SGTC_2909 7941780 10.49 µM -0.0083570716142523 0.480071349164975 no 1746 0.496666049600319 552 1243215
SGTC_1587 estradiol valerate 56.1 µM -0.00870013810387427 0.479969702365439 no 1747 0.496529190850736 552 13791 A steroid.
SGTC_2393 9031399 185.94 µM -0.00882198525341273 0.479933600718273 no 1748 0.496480582736591 557 1526623 YDL150W RPC53
SGTC_3007 9078383 71.4286 µM -0.00899810283366049 0.479881419774267 no 1749 0.496410324776505 555 6496995
SGTC_82 0054-0107 293.755 µM -0.00934281003303849 0.479779289304559 no 1750 0.49627281228333 557 3104697
SGTC_1644 st010134 20.9 µM -0.0100098915299173 0.479581648973643 no 1751 0.496006697733364 551 3818134
SGTC_1369 1866-0067 208 µM -0.0107702357762575 0.479356383239825 no 1752 0.495703380645646 555 3531355
SGTC_2710 st078562 53.7235 µM -0.0122640494258222 0.478913833199876 no 1753 0.495107474800346 555 17250908
SGTC_2950 9072895 21.46 µM -0.0127344748713961 0.478774472578519 no 1754 0.494919816861678 557 17332245
SGTC_555 4296-0685 37 µM -0.014616524690859 0.478216953117628 no 1755 0.49416905793215 561 2908540 YHR072W ERG7
SGTC_2214 7179297 48.276 µM -0.0157171576648943 0.477890932385605 no 1756 0.493730019425353 554 769744
SGTC_3008 9078912 71.4286 µM -0.0174924698407277 0.47736509482683 no 1757 0.493021870062629 557 16648731
SGTC_803 4488-1585 147 µM -0.0176044869221132 0.477331917304548 no 1758 0.492977188593099 559 747204
SGTC_607 4491-0986 66.8 µM -0.0190538313602631 0.476902660796772 no 1759 0.492399080986563 557 698981 YDR232W HEM1
SGTC_3310 9130229 44.1445 µM -0.0192109183255729 0.47685613749962 no 1760 0.492336423823272 572 7761258
SGTC_3188 9110789 49.47 µM -0.020923916264133 0.476348832044916 no 1761 0.491653174189448 569 849217
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.023206261377867 0.475672973754063 no 1762 0.490742872048173 562 6710655
SGTC_1283 0922-0125 16.4 µM -0.0233959154579149 0.475616815658413 no 1763 0.490667231554044 558 3360884
SGTC_2497 7-hydroxyflavone 100 µM -0.0235563609830556 0.475569306828529 no 1764 0.490603240686476 581 5281894
SGTC_2995 9067767 71.4286 µM -0.0238930312533187 0.475469617982123 no 1765 0.490468966475938 567 11673567
SGTC_3100 9120536 49.47 µM -0.0249746923400947 0.475149346053312 no 1766 0.490037574948909 556 16421196
SGTC_2394 5221648 200 µM -0.0252816982502852 0.475058446767397 no 1767 0.489915135973172 560 788586
SGTC_992 3909-8734 162 µM -0.0275045796028115 0.474400328012226 no 1768 0.489028643617866 566 4288319
SGTC_2834 9001755 58.44 µM -0.0282516214448583 0.474179170195863 no 1769 0.48873073283768 575 2989575
SGTC_1609 st001574 46.4 µM -0.0285921789578459 0.474078352568069 no 1770 0.488594924911697 566 3960012
SGTC_1718 roemerine 11.9335 µM -0.0286033827775113 0.474075035850967 no 1771 0.488590457061681 556 235224 An aporphine alkaloid with mutagenic activity.
SGTC_596 1155-0152 116 µM -0.0287076492020313 0.474044169478805 no 1772 0.488548877851185 558 280313
SGTC_1607 st000305 50.6 µM -0.0288629674269754 0.47399819034386 no 1773 0.48848694051017 561 5457690
SGTC_3123 9126162 49.47 µM -0.0320887005188805 0.473043349950019 no 1774 0.487200657225471 556 25239884
SGTC_1588 farnesol 29.9 µM -0.0320898866924763 0.47304299886218 no 1775 0.487200184254249 560 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1219 1469-0211 33.1 µM -0.0330940426974032 0.472745792770973 no 1776 0.486799796694132 570 6822282
SGTC_1482 3346-2049 8.48 µM -0.0338777824309099 0.472513835143144 no 1777 0.486487305034161 569 3826804
SGTC_653 0203-0016 55.2 µM -0.0341310655816388 0.472438874799386 no 1778 0.486386318079224 565 295302
SGTC_2301 7769476 200 µM -0.0352498669489861 0.472107771970012 no 1779 0.485940249420294 572 977820
SGTC_3166 9102297 49.47 µM -0.0354163509392025 0.472058503632654 no 1780 0.485873873363481 569 25237072
SGTC_2754 granisetron 64.02 µM -0.0368237743083006 0.47164201582215 no 1781 0.485312758872331 573 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2652 actinonin 100 µM -0.0368843893719717 0.471624079172817 no 1782 0.485288593377251 566 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2207 7258803 200 µM -0.0375436570925536 0.471428998487885 no 1783 0.485025765670068 568 3666799
SGTC_2674 ligustilide 100 µM -0.0376775113606581 0.471389391162132 no 1784 0.484972403298532 563 5319022 A signalling regulator.
SGTC_1572 epiandrosterone 68.9 µM -0.0384289922817192 0.471167034076949 no 1785 0.484672822775575 559 441302 A steroid.
SGTC_67 0335-0847 266 µM -0.0390424813966627 0.470985514304347 no 1786 0.48442825958005 592 4552207 YOR254C SEC63
SGTC_1954 st077032 68.9 µM -0.0391605392680846 0.470950583913775 no 1787 0.484381197294813 603 698907
SGTC_1201 1889-3372 45.9 µM -0.0406151918440809 0.470520206787685 no 1788 0.483801336405032 562 5392199
SGTC_1801 st050089 28.441 µM -0.041903408301856 0.470139100596493 no 1789 0.483287849677141 571 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1675 st018485 24.5 µM -0.0423935956186381 0.469994090656457 no 1790 0.483092466858633 566 3323024
SGTC_718 1130-0073 349 µM -0.0424380826287227 0.469980930458229 no 1791 0.483074735067223 577 6740020
SGTC_1645 Cervolide 78 µM -0.0437787670261757 0.469584343115182 no 1792 0.482540376156407 571 23173 A fragrance.
SGTC_2162 5663267 200 µM -0.0438842532676198 0.469553140545391 no 1793 0.482498333640185 592 6456493
SGTC_2264 7948757 110.76 µM -0.0441268625095197 0.469481378040449 no 1794 0.482401640224426 572 2971411
SGTC_3013 9080133 71.4286 µM -0.0457286612240716 0.469007599610855 no 1795 0.48176325967269 567 17050193
SGTC_1203 3992-3522 103 µM -0.0467307820250005 0.46871121559038 no 1796 0.481363898314901 569 5322312
SGTC_2564 betulinic acid 100 µM -0.0476019016710683 0.468453590131394 no 1797 0.4810167582176 600 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2981 9013952 38.96 µM -0.0484381674497371 0.468206284802865 no 1798 0.480683520882048 572 2996344
SGTC_1694 st024011 44.9 µM -0.0486347489254715 0.468148152375097 no 1799 0.480605188541506 588 2787533
SGTC_1500 4488-1866 171 µM -0.0488917516668409 0.46807215339389 no 1800 0.480502781109475 577 2900003
SGTC_2622 2-methoxyxanthone 59.94 µM -0.0500364183397759 0.467733675063426 no 1801 0.480046683508997 571 71034 A hepatoprotective.
SGTC_1072 oxiconazole 14.9 nM -0.0500700365515432 0.467723734498017 no 1802 0.480033288572784 568 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3347 9188721 44.724 µM -0.0530554350421095 0.466841063315705 no 1803 0.478843869547127 576 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1181 1222-0449 220 µM -0.0534754714516588 0.466716887172386 no 1804 0.478676536812661 581 658318
SGTC_1947 st076332 61.6 µM -0.0538752127700637 0.466598713912916 no 1805 0.478517292660461 567 24208416
SGTC_2634 4'-methoxyflavone 100 µM -0.0540475376549765 0.466547771391907 no 1806 0.478448644995945 579 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3156 9099931 49.47 µM -0.0541872551350506 0.466506468643616 no 1807 0.478392987347651 570 18111053
SGTC_1027 k015-0025 8.67 µM -0.0548599578412675 0.466307611893633 no 1808 0.478125016412392 571 3598955
SGTC_2790 5423970 71.43 µM -0.0557784138820043 0.466036121919075 no 1809 0.477759165696813 573 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2105 5350118 200 µM -0.0567052597100897 0.465762167996992 no 1810 0.47738999205846 580 2133313
SGTC_54 0159-0055 9 µM -0.0568665387548575 0.465714499341688 no 1811 0.477325754683321 577 3319099
SGTC_468 gf-109203x 121 µM -0.0574883029208764 0.465530731399167 no 1812 0.47707811180823 566 2396 A protein kinase C inhibitor.
SGTC_584 0986-0246 15.4 µM -0.0581503683322417 0.46533506014551 no 1813 0.476814427055658 586 53315 YDR232W HEM1
SGTC_45 0kpi-0036 14.9 µM -0.0587319022493904 0.465163196622251 no 1814 0.476582824433663 564 2795021
SGTC_107 0358-0022 2.6945 µM -0.058923884819449 0.465106460512534 no 1815 0.47650636688314 583 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1591 genipin 88.4 µM -0.0591272196635682 0.465046370268312 no 1816 0.476425389203578 578 442424 A DNA cross-linking agent.
SGTC_1429 4049-0205 9.46 µM -0.059459345314237 0.46494822101676 no 1817 0.476293122947997 572 22774478
SGTC_3282 9108498 15.4605 µM -0.0599471110871562 0.464804081107685 no 1818 0.476098879057638 595 16459645
SGTC_2484 5809818 12.04 µM -0.0607577191657961 0.464564548130653 no 1819 0.475776081647611 577 2870548
SGTC_3144 9087057 49.47 µM -0.0623510814721818 0.464093750440656 no 1820 0.475141625221839 589 17249618
SGTC_1658 st012944 20 µM -0.062815588038857 0.463956510100164 no 1821 0.474956676461388 589 24207260
SGTC_128 0906-2981 13.371 µM -0.0628200995724601 0.46395517717035 no 1822 0.474954880167544 582 6740226
SGTC_1019 4262-0212 3.4 µM -0.0640769645359762 0.463583853003922 no 1823 0.474454471890978 573 4677213
SGTC_1945 st075991 56.6 µM -0.0649056901340706 0.463339034296609 no 1824 0.474124545038912 578 1084980
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0651755043794086 0.463259329873545 no 1825 0.474017132162592 588 75037 A free radical scavenger.
SGTC_2933 9026794 32.47 µM -0.066791497284936 0.462781988792945 no 1826 0.473373846239271 574 17586027
SGTC_1230 0170-0365 3.77 µM -0.0676724642253245 0.462521786345619 no 1827 0.473023184706155 574 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_165 k038-0023 64.381 µM -0.068550607193879 0.462262433946414 no 1828 0.472673668035581 579 46368543
SGTC_3305 9127027 53.8275 µM -0.0691015286270034 0.462099731955237 no 1829 0.472454402135319 588 41905295
SGTC_224 benfluorex 43.875 µM -0.069217083991383 0.462065606136246 no 1830 0.472408412331224 571 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2440 5628896 157.78 µM -0.069291261918616 0.462043700052288 no 1831 0.472378890500163 579 5522048
SGTC_2355 9061122 103.12 µM -0.0718447815195521 0.46128967016664 no 1832 0.471362717188658 586 5302957
SGTC_2522 biochanin a 4.94 µM -0.0732216255628772 0.460883158869738 no 1833 0.470814878933021 593 5280373 A possible chelator.
SGTC_3237 9133362 49.47 µM -0.0738976015716443 0.460683592822751 no 1834 0.470545932150669 591 43845137
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0755974722038001 0.460181789796199 no 1835 0.469869673800154 580 5282309
SGTC_41 0478-0632 82.643 µM -0.0756019342673239 0.460180472674952 no 1836 0.469867898774028 578 3750424
SGTC_3325 9138760 55.175 µM -0.0793125756756324 0.459085310421049 no 1837 0.468392001935154 594 43844959
SGTC_2772 vinpocetine 57.06 µM -0.0794586708637476 0.45904219804497 no 1838 0.468333901752364 577 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1486 3970-0793 4.53 µM -0.079559941659421 0.459012313533433 no 1839 0.468293628051345 598 2844330
SGTC_2270 7924575 90.91 µM -0.0813656622124582 0.458479493361871 no 1840 0.467575578061737 613 1262135
SGTC_2416 tofa 880 nM -0.0816096125882047 0.458407515784129 no 1841 0.467478578527838 587 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_124 0136-0217 7.121 µM -0.0819648469652874 0.458302706292421 no 1842 0.467337333710935 592 3976905
SGTC_697 0508-1955 564 µM -0.0823944635501975 0.458175954708962 no 1843 0.467166519264427 575 6243113
SGTC_2642 cholecalciferol 100 µM -0.0826858623683202 0.458089984512983 no 1844 0.467050663285133 588 9821465 A vitamin D precursor, similar to steriods.
SGTC_368 fentichlor 4.58 µM -0.0837276935214564 0.457782633412358 no 1845 0.466636469101694 585 7329 A pesticide.
SGTC_3033 9090887 49.47 µM -0.083964544650488 0.457712763364207 no 1846 0.466542310729527 574 19325384
SGTC_2347 9049783 174.81 µM -0.0841845782623566 0.45764785558105 no 1847 0.466454839711605 599 6467988 YPL169C MEX67
SGTC_858 0438-0351 2.77 µM -0.0842547828522196 0.457627146145011 no 1848 0.466426931284755 589 2799119
SGTC_1231 0242-0792 125 µM -0.084818752931986 0.457460786524794 no 1849 0.466202742290358 595 3707635
SGTC_1359 1582-0056 520 nM -0.0848533164101959 0.457450591248874 no 1850 0.466189002988537 601 3661189
SGTC_1867 st057372 64 µM -0.0854242404365319 0.457282188412113 no 1851 0.465962061257147 590 688837
SGTC_2894 9048625 32.47 µM -0.086611723835166 0.456931946492319 no 1852 0.4654900733251 581 4092861
SGTC_1381 2324-0066 62.1 µM -0.0871403612019575 0.456776038453992 no 1853 0.465279971893518 600 10885928
SGTC_1200 1643-0193 18.4 µM -0.0872595263312445 0.456740894672297 no 1854 0.46523261228505 609 5403974
SGTC_2808 7946468 45.46 µM -0.0873511144590489 0.456713884037666 no 1855 0.465196212895237 621 2970879
SGTC_2001 4023502 57.655 µM -0.0884244499030512 0.456397357168504 no 1856 0.464769664596737 587 108941 YCR052W RSC6
SGTC_1657 st012939 43.4 µM -0.0901987990801689 0.45587416195392 no 1857 0.464064619316933 592 24207257
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0903359535019867 0.455833722954406 no 1858 0.46401012508696 592 1241132 A phosphatase inhibitor.
SGTC_2918 7977171 22.06 µM -0.0910085151074119 0.455635429609946 no 1859 0.463742912530065 584 2236483
SGTC_1425 4048-4433 7.33 µM -0.0913288819022334 0.455540978794873 no 1860 0.463615634721054 587 23734946
SGTC_986 1493-0483 84 µM -0.0919317225821777 0.455363255602114 no 1861 0.463376143599577 589 40079
SGTC_1681 tripelennamine 100 µM -0.0923943061357106 0.455226887605534 no 1862 0.463192381562422 576 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1121 fusaric acid 630.51 nM -0.0926253878335067 0.455158767512718 no 1863 0.463100586937231 597 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1013 4112-3890 241 µM -0.0934300309561115 0.454921578742529 no 1864 0.462780966801168 580 705171
SGTC_2639 lactacystin 53 µM -0.0942216078829489 0.454688257242083 no 1865 0.462466560260332 597 3870 A proteasome inhibitor.
SGTC_376 3970-0862 59.1 µM -0.0950889372880496 0.454432625247335 no 1866 0.462122092512199 620 3135186
SGTC_2405 ticlatone 3.52 µM -0.0963071382562968 0.454073611151403 no 1867 0.461638320966855 615 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2963 9082507 9 µM -0.0972144724340641 0.453806236483857 no 1868 0.461278037571419 602 16459611
SGTC_92 0063-0024 660.874 µM -0.0973413084404171 0.453768861914355 no 1869 0.461227676175096 582 3594437
SGTC_132 0417-1715 25.805 µM -0.0979210942776212 0.453598022538087 no 1870 0.460997474835317 595 6769098
SGTC_1473 k844-0725 134 µM -0.100601769464241 0.452808248377297 no 1871 0.45993329600277 582 54682906
SGTC_2691 st077356 60.2 µM -0.102335865751122 0.452297452273096 no 1872 0.45924504399111 606 2839272
SGTC_296 1222-0039 74.9 µM -0.102604767830812 0.452218251416327 no 1873 0.459138329316727 605 5984176
SGTC_1803 st050068 52.4 µM -0.102716911079752 0.452185221956751 no 1874 0.459093825769242 600 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_387 norethindrone acetate 66.7 µM -0.103365121150914 0.451994311665099 no 1875 0.458836596560128 618 541197
SGTC_300 r073-0011 5.04 µM -0.103680673005552 0.451901379609265 no 1876 0.458711382344813 591 2735780
SGTC_1792 st045773 43.6 µM -0.104013595079768 0.451803334768948 no 1877 0.458579279889275 609 2919270
SGTC_169 k015-0017 16.025 µM -0.104235651861621 0.451737941154449 no 1878 0.458491170983105 611 1840002
SGTC_1296 1068-0102 11.9 µM -0.105435747272223 0.451384547154462 no 1879 0.458015025955844 615 767053
SGTC_3065 9113888 49.47 µM -0.106169895077673 0.451168380459813 no 1880 0.457723778082139 627 16648368
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.107625790171339 0.450739741244036 no 1881 0.457146269108979 599 3256 An antibiotic and ribosome inhibitor.
SGTC_346 4513-0042 7.16 µM -0.109306276497706 0.450245050163559 no 1882 0.456479784250897 604 2827372
SGTC_2828 7998861 71.43 µM -0.110266946842401 0.449962288694676 no 1883 0.456098834989048 586 2988188
SGTC_948 3448-0295 75.3 µM -0.112771989760801 0.44922508003926 no 1884 0.45510566279279 601 678569
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.11326362061877 0.449080418568594 no 1885 0.454910779069302 606 229346 A bile salt which induces apoptosis.
SGTC_713 1488-1073 324 µM -0.118294101640008 0.447600601147688 no 1886 0.452917315397823 611 3312542
SGTC_896 0964-0007 44.5 µM -0.119247282379239 0.447320285348352 no 1887 0.452539723971077 592 6756758
SGTC_909 3448-9333 149 µM -0.121540859101207 0.446645887795418 no 1888 0.451631326841787 612 3344074
SGTC_914 3820-6779 408 µM -0.122165578733935 0.446462223451781 no 1889 0.451383943207054 601 2893481
SGTC_1312 1218-2183 165 µM -0.12256064610737 0.446346081610848 no 1890 0.451227509642726 590 6744073
SGTC_3343 9148379 18.9835 µM -0.122580363348351 0.446340285260121 no 1891 0.451219702468121 602 1955036
SGTC_1895 st058434 18.3 µM -0.12460699496667 0.445744570196356 no 1892 0.45041734519044 651 5393175
SGTC_1828 st055811 49 µM -0.125104313258486 0.445598405409824 no 1893 0.450220484320205 644 5877589
SGTC_1583 clindamycin 39.6 µM -0.126115135526711 0.445301341576238 no 1894 0.449820393357094 621 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_338 4055-0136 114 µM -0.126932077012058 0.445061278508526 no 1895 0.449497079094671 597 2900563
SGTC_1185 1319-0113 81.3 µM -0.131354265535733 0.443762144268132 no 1896 0.44774753296317 615 4672763
SGTC_3152 9099253 49.47 µM -0.133049190866308 0.443264374742735 no 1897 0.447077238799151 612 25236131
SGTC_901 1112-0062 60.1 µM -0.13344665340868 0.44314765996816 no 1898 0.446920075615388 591 1908457
SGTC_2079 5212404 121 µM -0.134070435927179 0.44296449633928 no 1899 0.446673438631103 613 758462
SGTC_2018 5133068 143 µM -0.134971020847006 0.442700075681115 no 1900 0.446317393326252 614 785362
SGTC_2330 7979373 200 µM -0.135460815295678 0.442556277883492 no 1901 0.446123771754046 612 1863007
SGTC_3349 9149703 23.001 µM -0.136547581968615 0.442237243224241 no 1902 0.445694205898996 613 4910494
SGTC_875 0709-0210 25.7 µM -0.138051695082951 0.441795752867628 no 1903 0.445099780935921 616 6251364
SGTC_2589 lobaric acid 100 µM -0.138771368034061 0.441584538529365 no 1904 0.444815410015498 609 73157 A novel microtubule depolymerizer.
SGTC_864 0469-0573 172 µM -0.13906214630671 0.441499203722636 no 1905 0.444700520198305 636 689425
SGTC_2332 7982454 138.89 µM -0.139094974005497 0.441489569936304 no 1906 0.444687549891176 606 2981748
SGTC_3044 9093193 49.47 µM -0.139269462600622 0.441438364191519 no 1907 0.444618609998614 643 25236277
SGTC_201 4262-0159 12.803 µM -0.140149598587219 0.441180092800384 no 1908 0.444270896630883 601 1341029
SGTC_2436 5633522 8.09 µM -0.141583062783822 0.440759503674947 no 1909 0.443704673043949 634 5724242
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.142777748276268 0.440409025036414 no 1910 0.44323285565724 608 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_573 3702-0553 84.7 µM -0.142823346985449 0.440395648904563 no 1911 0.44321484893984 624 1222756
SGTC_1466 k213-0079 57.5 µM -0.144243064625859 0.439979216605118 no 1912 0.442654267920723 620 3657981
SGTC_1081 sertraline 6 µM -0.14493285181213 0.43977691181345 no 1913 0.442381944138855 605 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_499 genistein 192 µM -0.147235455886814 0.439101704865408 no 1914 0.44147308790015 621 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1284 0929-0043 16 µM -0.149377104313888 0.43847385491339 no 1915 0.440628038567027 618 1239883
SGTC_2103 5378138 10 µM -0.149565031290358 0.4384187692291 no 1916 0.44055389938761 606 244142
SGTC_791 1348-1292 225 µM -0.151071059277949 0.437977361244877 no 1917 0.439959830901438 612 5437054
SGTC_768 0384-0033 77.3 µM -0.152489974386787 0.437561556119236 no 1918 0.439400248623614 620 3965305 YMR134W ERG29
SGTC_668 1682-0499 62.6 µM -0.153124117260994 0.437375746365895 no 1919 0.439150198663965 614 682214
SGTC_2889 9059656 51.95 µM -0.155487887281675 0.436683261798271 no 1920 0.438218351179349 622 3949838
SGTC_1164 k060-0068 93.7 µM -0.156189755231096 0.436477681451628 no 1921 0.437941725886296 608 5963676
SGTC_2429 5902844 64.44 µM -0.158505016193083 0.435799652819095 no 1922 0.437029434140335 630 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3236 9132701 49.47 µM -0.158739699966752 0.435730935721393 no 1923 0.436936979337943 646 24282524
SGTC_2037 5169046 200 µM -0.159718438510382 0.435444374975925 no 1924 0.436551437767708 630 5718022
SGTC_3238 9133470 49.47 µM -0.160413544409845 0.435240878416483 no 1925 0.436277660442666 624 3534688
SGTC_1879 gemcitabine 100 µM -0.165302939860963 0.433809965179609 no 1926 0.434352772489644 622 60750 A nucleoside analog which inhibits DNA replication.
SGTC_865 0488-0499 301 µM -0.16602208105446 0.43359957654286 no 1927 0.434069786574833 617 9634651
SGTC_3332 9141069 11.198 µM -0.166262391065675 0.433529276743016 no 1928 0.433975230821173 629 17332883
SGTC_94 0334-0113 514.748 µM -0.166543570334074 0.433447023804054 no 1929 0.433864598871932 618 6795178
SGTC_3082 9117008 49.47 µM -0.16664166864682 0.433418327933557 no 1930 0.433826002623415 607 41448529
SGTC_2805 7950783 58.44 µM -0.166919112931289 0.433337171402059 no 1931 0.433716847092902 627 1178958 YDL195W SEC31
SGTC_50 0929-0078 56.389 µM -0.168555012851952 0.432858703890288 no 1932 0.433073334343523 626 1377751
SGTC_3004 9076122 71.4286 µM -0.168927292625199 0.432749833336982 no 1933 0.432926915643891 651 44782551
SGTC_3229 9132204 49.47 µM -0.172504094685991 0.431704084511595 no 1934 0.431520621261435 613 17682924
SGTC_2013 4024628 200 µM -0.172673577183466 0.431654544766227 no 1935 0.431454007067682 636 5230760
SGTC_3318 9139014 38.6185 µM -0.174522080293977 0.431114297141757 no 1936 0.43072758973597 628 16643984
SGTC_3231 9132313 49.47 µM -0.174765080329258 0.431043286973426 no 1937 0.430632113931136 647 4905967
SGTC_1696 st025591 34.7925 µM -0.175836548015076 0.430730206221903 no 1938 0.430211177894873 623 2787147
SGTC_2137 5261020 140 µM -0.178393584036339 0.429983221582784 no 1939 0.429206943843374 635 763655
SGTC_2228 7354201 200 µM -0.179973474374273 0.429521814687171 no 1940 0.428586696267162 626 753451
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.180962772266957 0.429232939256307 no 1941 0.428198398476173 647 6708760
SGTC_2807 7945238 51.95 µM -0.181582606402316 0.429051966708659 no 1942 0.427955149995281 659 17148797
SGTC_2205 7238770 200 µM -0.182503901159389 0.42878300447708 no 1943 0.427593646545403 645 279867
SGTC_2365 9042475 200 µM -0.182563103285035 0.428765722173948 no 1944 0.427570418516905 622 6464479
SGTC_246 cycloheximide 667 µM -0.182842363683264 0.428684202232895 no 1945 0.427460853734685 622 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1540 guanosine 70.6 µM -0.18547605485632 0.427915541770355 no 1946 0.426427829933738 614 6802 Guanosine is a purine nucleoside
SGTC_2755 lomerizine 42.69 µM -0.18590976916928 0.427788985482486 no 1947 0.426257760534812 629 3949 A calcium channel blocker.
SGTC_3187 9109394 49.47 µM -0.186622002696212 0.427581174404523 no 1948 0.425978507082364 631 17098090
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.188668278918033 0.426984236596373 no 1949 0.425176407400124 622 2333 A French combination drug.
SGTC_485 niflumic acid 177 µM -0.190413053683342 0.426475384493847 no 1950 0.424492734720584 641 4488 A COX2 inhibitor.
SGTC_2603 homopterocarpin 100 µM -0.19048608043829 0.426454089382364 no 1951 0.424464124848732 639 101795 A weak amylase inhibitor.
SGTC_740 k014-0057 261 µM -0.190942745206626 0.426320927613308 no 1952 0.424285225198035 652 4012779
SGTC_116 0155-0182 31.788 µM -0.191338165643402 0.426205631250947 no 1953 0.424130330778674 637 771486
SGTC_1976 st070609 63.5 µM -0.19149689238914 0.426159351611784 no 1954 0.424068157501869 615 682556
SGTC_3015 9080845 49.47 µM -0.191982144416181 0.426017873959776 no 1955 0.423878095976925 656 5296973
SGTC_126 0417-1624 672.48 µM -0.192345776249386 0.425911861522887 no 1956 0.423735681753697 654 41912 YDL195W SEC31
SGTC_2720 fluspirilene 36.88 µM -0.192870828727564 0.425758798310225 no 1957 0.42353006568356 645 3396 An atypical antipsychotic.
SGTC_2537 larixol 68.93 µM -0.192890672304405 0.425753013733172 no 1958 0.42352229513824 630 6708759
SGTC_2250 alverine citrate 130 µM -0.193321333691002 0.425627476092446 no 1959 0.423353659798511 619 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_465 cgp-37157 41 µM -0.195210560840976 0.42507685628854 no 1960 0.422614055875579 637 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_245 methotrexate 289.6 µM -0.195340877233379 0.425038880637295 no 1961 0.42256304899973 623 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_958 1222-0007 33 µM -0.195708601408428 0.424931725460264 no 1962 0.422419125827309 666 7312461
SGTC_365 0121-0052 13.6 µM -0.19665793114705 0.42465511552559 no 1963 0.422047616604024 632 3101739
SGTC_1937 st074714 47.2 µM -0.197565974156609 0.424390570178981 no 1964 0.421692329353862 651 17250970
SGTC_2100 5377183 190 µM -0.198860479686743 0.424013493416855 no 1965 0.421185942338588 634 2844202
SGTC_1557 sumaresinolic acid 42.3 µM -0.199412930786042 0.423852590987029 no 1966 0.420969873152509 639 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1778 st046819 58.9 µM -0.199868315985869 0.423719968727668 no 1967 0.420791785310488 615 671715
SGTC_2215 7188065 200 µM -0.200210429950851 0.423620340239125 no 1968 0.420658005198173 641 940217
SGTC_113 0099-0221 2.5 µM -0.20048075800243 0.423541620290066 no 1969 0.42055230270153 620 89219
SGTC_2366 9070441 60.58 µM -0.200904663242887 0.423418184570325 no 1970 0.420386560659119 658 6837235
SGTC_1619 st003326 88.7 µM -0.204138582029583 0.422476757498534 no 1971 0.419122602499522 611 2849032
SGTC_2344 7990960 76.95 µM -0.204959167560699 0.422237946798091 no 1972 0.418802013647738 652 140813
SGTC_3180 9109287 49.47 µM -0.205152302177326 0.422181743996721 no 1973 0.418726567058444 629 18891271
SGTC_320 4092-0846 5.34 µM -0.205375283310476 0.422116857732901 no 1974 0.418639464869434 626 1359356
SGTC_3317 9138495 8.753 µM -0.206599174259642 0.421760749994604 no 1975 0.418161452598724 628 17020139
SGTC_2468 5987765 72.9 µM -0.20728746496709 0.421560510524882 no 1976 0.417892681531049 622 26772094
SGTC_1393 3470-5649 58.2 µM -0.207643884206337 0.421456828004013 no 1977 0.417753518221132 646 4108395
SGTC_2126 5251174 33.877 µM -0.208381801893787 0.42124218472473 no 1978 0.417465432218038 647 790722
SGTC_1221 2958-7315 257 µM -0.209718715822985 0.420853366872617 no 1979 0.416943608623549 652 4562705
SGTC_1875 nocodazole 6 µM -0.209898368367741 0.420801123971623 no 1980 0.41687349785972 627 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1501 4491-0275 38.4 µM -0.212362548305305 0.420084682407149 no 1981 0.415912100760276 645 5104718
SGTC_1245 0418-0076 17.2 µM -0.212413944117631 0.420069742276006 no 1982 0.415892054075745 691 6790114
SGTC_794 k038-0031 316 µM -0.213765113307947 0.419677015373293 no 1983 0.415365115817804 630 6624242
SGTC_3164 9100705 49.47 µM -0.213893497504983 0.419639703751407 no 1984 0.415315055567411 645 17174235
SGTC_2493 resveratrol 26.09 µM -0.21418807781194 0.419554094161998 no 1985 0.41520019644108 629 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_767 0929-0023 86 µM -0.214977261915946 0.419324763840247 no 1986 0.414892523231153 625 1204563
SGTC_3354 9151612 71.43 µM -0.216492141534829 0.418884629300934 no 1987 0.414302075036677 664 27261949
SGTC_2667 digitoxin 100 µM -0.216900393128727 0.418766032842612 no 1988 0.414142985612536 627 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2067 5224629 34.075 µM -0.217139480697614 0.418696581699653 no 1989 0.414049823369697 654 2835000
SGTC_1833 st055984 71 µM -0.217991499676282 0.41844910433362 no 1990 0.413717867224061 632 676288
SGTC_3070 9117005 49.47 µM -0.218336659663016 0.418348858371638 no 1991 0.413583406556949 640 8779016
SGTC_1235 benzylparaben 21.5 µM -0.218381319757454 0.41833588797935 no 1992 0.413566009492128 670 7180
SGTC_1739 st037196 92.5 µM -0.220706534632182 0.417660711253091 no 1993 0.412660471514609 671 612214
SGTC_193 1273-0060 1.558 µM -0.221672427280224 0.417380314530032 no 1994 0.412284447979717 672 2847393 YHR072W ERG7
SGTC_384 k007-0144 5.16 µM -0.221996635307418 0.417286206991452 no 1995 0.412158251311115 647 6824886
SGTC_3006 9075424 71.4286 µM -0.223186414602172 0.416940891588786 no 1996 0.411695212433471 642 7465181
SGTC_1913 st060213 96.1 µM -0.223693612725007 0.416793704485563 no 1997 0.411497858163416 683 688959
SGTC_1413 3910-0535 34.4 µM -0.225534515559451 0.416259579123046 no 1998 0.410781738704599 641 2876951
SGTC_1307 1187-1599 12.2 µM -0.225836659316778 0.416171928923145 no 1999 0.410664231764943 651 1538471
SGTC_1116 jasmonic acid 1.58368 µM -0.225890875746351 0.416156201483732 no 2000 0.410643147263599 678 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2508 celastrol 40.54 µM -0.226756437112717 0.415905132251762 no 2001 0.410306569737097 631 122724 Celastrol is a natural product and antioxidant.
SGTC_140 0062-0056 502.533 µM -0.227293232000452 0.415749443969482 no 2002 0.410097867740749 648 3758964
SGTC_3132 9126706 49.47 µM -0.2287229223194 0.415334851034263 no 2003 0.40954213878593 658 850858
SGTC_1247 0448-0043 5.84 µM -0.228970935614494 0.415262939752412 no 2004 0.409445753036818 668 3089013 YGL099W LSG1
SGTC_1729 st035615 45.989 µM -0.230287232978013 0.414881327815866 no 2005 0.408934290323133 631 17385451
SGTC_674 0498-0004 451 µM -0.230588380039801 0.414794032592629 no 2006 0.408817297874083 657 4231473
SGTC_431 k089-0097 107 µM -0.231839406786369 0.414431435396349 no 2007 0.408331374296771 677 5499420
SGTC_979 1426-2828 121 µM -0.234118286613164 0.413771113166874 no 2008 0.407446574865642 660 747872
SGTC_2219 9098279 200 µM -0.234970338210235 0.413524287439597 no 2009 0.407115877714307 645 902349
SGTC_766 1391-0721 126 µM -0.237008882182392 0.412933892675371 no 2010 0.406324949786687 692 1020919 YIL115C NUP159
SGTC_2453 5731132 22.18 µM -0.23929256524356 0.41227273559289 no 2011 0.405439365024936 684 1362040
SGTC_1291 0993-0025 5.79 µM -0.23932667139129 0.412262863284267 no 2012 0.405426142727907 661 4353356
SGTC_520 3584-0023 682 µM -0.243123266867968 0.411164255533666 no 2013 0.403954953759011 643 1340790
SGTC_101 0490-5701 117.494 µM -0.243876717511793 0.410946314650439 no 2014 0.403663150783008 647 4661669
SGTC_34 0469-0683 81.75 µM -0.244220051234195 0.410847012075439 no 2015 0.403530199258954 647 3690923
SGTC_3300 9124615 50.48 µM -0.244598516863128 0.410737554903137 no 2016 0.403383656277786 666 24824903
SGTC_2455 5377712 9.75 µM -0.245538288944638 0.410465790695537 no 2017 0.403019832526525 634 2243908
SGTC_1963 st076565 50.3 µM -0.246715110842271 0.410125536820523 no 2018 0.402564355621349 644 4914280
SGTC_1149 3909-7961 23.3 µM -0.247056003412142 0.410026987362857 no 2019 0.402432441303269 638 735261
SGTC_1864 st057645 30.4 µM -0.247407215284538 0.409925460616321 no 2020 0.402296545370301 651 688666
SGTC_814 3342-0569 96 µM -0.24746113058761 0.409909875557762 no 2021 0.402275684733315 651 4346283
SGTC_617 3770-0098 35 µM -0.247531437111483 0.409889552575202 no 2022 0.402248482506006 666 5962639
SGTC_2953 9074162 66.49 µM -0.248445567183623 0.409625333866435 no 2023 0.401894840486296 642 16451992
SGTC_2128 5255449 168.493 µM -0.248552899675458 0.409594313342843 no 2024 0.401853322906436 642 736008
SGTC_926 2268-1401 59.4 µM -0.249118965539489 0.409430722115886 no 2025 0.40163437972896 645 2931578
SGTC_2490 carminic acid 95.39 µM -0.250090020241736 0.409150127151333 no 2026 0.401258866751452 685 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2072 5231554 129 µM -0.250782169953052 0.408950152688052 no 2027 0.400991263733169 675 789545
SGTC_2369 9071472 200 µM -0.251668626627579 0.408694074074975 no 2028 0.400648604457668 647 17296037
SGTC_3043 9092303 49.47 µM -0.252105261284244 0.40856795386365 no 2029 0.400479851684606 663 25236084
SGTC_900 1112-0045 141 µM -0.252959075223456 0.408321360421434 no 2030 0.400149919051792 658 56211 YIL048W NEO1
SGTC_2398 5228213 48.84 µM -0.25530258348861 0.407644709192728 no 2031 0.399244702356162 668 80771 YMR134W ERG29
SGTC_1042 0350-0096 82 µM -0.255375157540607 0.407623758960832 no 2032 0.399216678113508 640 3122515
SGTC_3245 9134821 49.47 µM -0.256058140764972 0.407426612505138 no 2033 0.398952971744939 670 17014901
SGTC_2171 5739187 198.077 µM -0.256752610923051 0.407226174330011 no 2034 0.398684877445558 639 2262761
SGTC_880 0833-0487 87.2 µM -0.258164217698361 0.406818830901448 no 2035 0.398140086103225 650 76075
SGTC_2727 riluzole 51.77 µM -0.261745769549553 0.40578576570846 no 2036 0.396758725644017 666 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_106 0092-0003 11.579 µM -0.262487694636473 0.405571846101136 no 2037 0.396472735562027 665 1072148
SGTC_208 k072-0098 12.366 µM -0.262617298837788 0.40553448015271 no 2038 0.396422782702047 676 5948901
SGTC_1481 3346-2004 36 µM -0.262802422974632 0.405481108847057 no 2039 0.396351433950943 677 2770522
SGTC_1513 0337-0559 19 µM -0.262839789428933 0.40547033630797 no 2040 0.396337032955129 634 775073
SGTC_359 0081-0058 15.9 µM -0.264109204107156 0.405104413765874 no 2041 0.395847885890944 683 3494159
SGTC_1216 1165-0504 9.65 µM -0.264184781342436 0.405082630421618 no 2042 0.395818768670503 670 6304004
SGTC_3213 9129884 49.47 µM -0.265534915128149 0.404693536015854 no 2043 0.395298708252331 679 17190742
SGTC_537 1334-0398 209 µM -0.266173864955311 0.404509430195455 no 2044 0.395052654970279 677 5846986
SGTC_2952 9073731 13.78 µM -0.266753339802908 0.404342479665174 no 2045 0.394829541096403 683 16457353
SGTC_1656 st012921 11 µM -0.268027484924656 0.403975451335367 no 2046 0.3943390812919 661 6732821
SGTC_778 3456-2434 196 µM -0.269229456283943 0.403629290738417 no 2047 0.393876557003703 670 5539063
SGTC_1300 1094-0077 113 µM -0.270304481662799 0.403319753759139 no 2048 0.393463008891242 657 5532636
SGTC_316 k060-0003 58.6 µM -0.270383068154386 0.403297128363901 no 2049 0.393432782409768 674 6152314
SGTC_2432 5630864 12.22 µM -0.270823838747834 0.403170234580192 no 2050 0.393263262075024 691 5714970
SGTC_86 0417-1630 471.922 µM -0.27141642041329 0.402999651860905 no 2051 0.393035387108427 655 3634867
SGTC_2744 captopril 92.04 µM -0.275738329071049 0.401756091722996 no 2052 0.391374527042196 662 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.276240616204162 0.401611630870711 no 2053 0.391181631598989 682 4174840
SGTC_966 1300-0360 30.2 µM -0.279470278207131 0.400683082282101 no 2054 0.389941972118146 679 70588
SGTC_630 4356-0227 183 µM -0.280919252301681 0.400266674875429 no 2055 0.389386166904918 693 779312
SGTC_1944 st076371 56.9 µM -0.281674832206938 0.400049580614113 no 2056 0.389096427193603 651 24208455
SGTC_49 0717-0965 32.132 µM -0.282505641871718 0.399810906887336 no 2057 0.38877791055491 737 5889349 YGL099W LSG1
SGTC_1851 st056236 18.9 µM -0.282536617966936 0.399802008845381 no 2058 0.388766036352795 662 5393171
SGTC_3083 9117465 49.47 µM -0.282596325988806 0.399784857557192 no 2059 0.388743148508744 714 16420915
SGTC_189 3970-0742 2.116 µM -0.282929370190286 0.39968919327193 no 2060 0.388615489940196 692 2891807
SGTC_1140 3229-1848 2.98 µM -0.284436601935455 0.399256328364596 no 2061 0.388037906263036 695 2849525
SGTC_1968 st069590 43.6 µM -0.284571368004785 0.399217630650364 no 2062 0.387986274829558 676 6384066
SGTC_3272 9137413 49.47 µM -0.285142601195247 0.399053613576349 no 2063 0.387767446569974 705 17614870
SGTC_27 0485-0001 32.618 µM -0.28562568692968 0.398914920016693 no 2064 0.387582413688881 659 2054479
SGTC_2091 4-phenylthiadiazole 200 µM -0.286123347713117 0.398772055316649 no 2065 0.387391824927575 662 270010
SGTC_1516 st013856 110 µM -0.287217120197323 0.398458111054622 no 2066 0.386973039156072 691 5281404 A mutagen and neurotoxin.
SGTC_1251 0490-5699 265 µM -0.28755743595585 0.398360444005462 no 2067 0.386842765194886 677 3883818
SGTC_1452 4194-0072 190 µM -0.291337976967681 0.397275897957368 no 2068 0.385396422547361 690 1343545
SGTC_2819 7996655 46.38 µM -0.291545918496383 0.397216267502129 no 2069 0.38531691521973 684 6456960
SGTC_2867 9039098 71.43 µM -0.291950289953018 0.397100314601312 no 2070 0.38516231587695 668 6463460
SGTC_164 4100-3994 89.624 µM -0.292069554845391 0.397066117311005 no 2071 0.385116721993417 681 4615967
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.292189444993458 0.397031741536331 no 2072 0.385070890681005 696 15053
SGTC_1737 st035557 69.7 µM -0.292566759820464 0.39692356030849 no 2073 0.3849266621723 654 5716916
SGTC_375 3970-0961 9.27 µM -0.292694566297141 0.39688691827326 no 2074 0.384877811783741 663 2898222
SGTC_2251 lansoprazole 556 µM -0.293286652396841 0.396717179448945 no 2075 0.384651527575488 705 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_619 1652-1634 108 µM -0.297199704844031 0.39559588179071 no 2076 0.38315702359882 687 5400454
SGTC_2185 6113692 200 µM -0.297233624516123 0.395586165762874 no 2077 0.383144076292794 685 874150
SGTC_1568 digitonin 820 nM -0.300155439088602 0.394749478721028 no 2078 0.38202929661905 711 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1226 3909-7979 35.4 µM -0.300385423712116 0.394683641171198 no 2079 0.381941590405125 662 6615510
SGTC_414 piperonyl butoxide 100 µM -0.300773052931838 0.394572681612257 no 2080 0.38179377905708 688 5794 A potent inhibitor of cytochrome P450.
SGTC_2778 tioconazole 65.09 nM -0.301092543030202 0.394481233428352 no 2081 0.381671963573428 699 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_75 0159-0059 199.013 µM -0.301417222692265 0.394388305784446 no 2082 0.381548181412788 654 5377270
SGTC_509 pifithrin 175 µM -0.302166482837773 0.394173880498607 no 2083 0.381262576757224 684 4817 A p53 inhibitor.
SGTC_2379 9035213 200 µM -0.302462329385659 0.394089223164995 no 2084 0.381149823105687 653 646551
SGTC_3106 9121286 49.47 µM -0.303122834432101 0.39390023582376 no 2085 0.380898126468733 660 15943471
SGTC_220 paclitaxel 373.376 µM -0.304441804248928 0.393522919716133 no 2086 0.380395661551368 691 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2988 9073640 71.4286 µM -0.305307668848681 0.393275277202186 no 2087 0.380065917853034 707 9102229
SGTC_639 0833-0042 114 µM -0.305504662416008 0.393218941875389 no 2088 0.379990909755309 698 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_341 1486-1430 230 µM -0.307922985208051 0.392527543437088 no 2089 0.379070467672965 686 2054753 YPL210C SRP72
SGTC_2709 st078560 56 µM -0.308401502926404 0.392390775343979 no 2090 0.378888419249809 706 17250903
SGTC_1242 0402-0103 60.1 µM -0.30858217011314 0.392339141199017 no 2091 0.378819692777959 671 432868
SGTC_1282 0886-0010 32.4 µM -0.311065685554892 0.391629552338076 no 2092 0.377875343445174 675 2836211 YNL267W PIK1
SGTC_287 k060-0039 29.6 µM -0.312028038145998 0.391354686166532 no 2093 0.377509607500376 685 5861974
SGTC_2600 tangeritin 87.95 µM -0.313159761528077 0.391031513893738 no 2094 0.377079643789284 703 68077 A bioactive flavone.
SGTC_258 haloperidol 50.781 µM -0.313437564302322 0.39095219667681 no 2095 0.376974124385877 673 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1290 0986-0249 10.2 µM -0.314803328393008 0.390562314809707 no 2096 0.376455492220979 694 53329
SGTC_634 1611-4317 11.2 µM -0.315052407193332 0.390491222646167 no 2097 0.376360931611688 688 2843522
SGTC_660 4031-1742 102 µM -0.316025484192026 0.390213521758521 no 2098 0.375991582524508 665 6738706
SGTC_1006 4099-6547 255 µM -0.316671203971536 0.390029274385492 no 2099 0.375746550492329 683 3146833
SGTC_191 3914-0123 66.505 µM -0.31763605032226 0.389754014622504 no 2100 0.375380512516573 720 3144412
SGTC_3038 9091290 49.47 µM -0.319334324845 0.389269650462646 no 2101 0.374736503337366 717 25236843
SGTC_2965 9082772 38.63 µM -0.320510008039087 0.388934435058621 no 2102 0.374290872443035 668 16459634
SGTC_29 0299-0004 12.984 µM -0.320589716554939 0.388911711243416 no 2103 0.374260665802413 693 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2054 5233173 129 µM -0.32090965722535 0.388820504328836 no 2104 0.374139427644811 664 6889
SGTC_3042 9091578 49.47 µM -0.321635774485215 0.388613529583256 no 2105 0.373864319332006 662 25236497
SGTC_1498 4478-3555 97.6 µM -0.322298382764935 0.388424685225879 no 2106 0.373613329096469 686 3437919
SGTC_3017 9080681 49.47 µM -0.323159900517426 0.388179190808953 no 2107 0.373287073845999 703 16451914
SGTC_1617 st002906 78 µM -0.323953691152497 0.387953035162422 no 2108 0.372986547120764 701 5150859
SGTC_2802 7925815 54.55 µM -0.327009246680661 0.387082844601672 no 2109 0.3718304457654 685 1262923
SGTC_504 lovastatin 124 µM -0.327056596156274 0.38706936441323 no 2110 0.371812539656289 731 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_646 4092-0839 27.3 µM -0.329988506040619 0.386234928440301 no 2111 0.370704323493212 706 877796
SGTC_632 0781-2353 4.65 µM -0.331174377733257 0.385897572682526 no 2112 0.370256386421111 695 6811515 YHR007C ERG11
SGTC_3177 9107506 49.47 µM -0.333591286337382 0.38521027994858 no 2113 0.369343997230626 705 8897194
SGTC_1104 tacrolimus 29.8 µM -0.333673043456179 0.385187037087394 no 2114 0.36931314653984 686 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1554 st069299 38.7 µM -0.336219610725423 0.384463276331587 no 2115 0.368352632818033 682 24207999
SGTC_651 3253-0966 34.4 µM -0.338721406541291 0.383752632051557 no 2116 0.367409806445781 685 781462
SGTC_2858 9025781 8.96 µM -0.339432000068167 0.383550856510281 no 2117 0.367142157687636 697 4894980 YPL153C RAD53
SGTC_3234 9132280 49.47 µM -0.339976144020887 0.383396366257747 no 2118 0.366937246663069 686 17612295
SGTC_1930 st074634 34.3 µM -0.340171053081154 0.383341033295445 no 2119 0.366863857995466 722 684253 YOR116C RPO31
SGTC_11 0438-0307 1.3 µM -0.340371670884276 0.383284082156578 no 2120 0.366788324909395 700 4011476
SGTC_1146 3579-1023 7 µM -0.341698645183932 0.382907445869574 no 2121 0.366288845897317 690 X1146
SGTC_1526 st051518 75 µM -0.342368689422992 0.382717308654442 no 2122 0.366036724256136 692 673993
SGTC_2518 prenyletin 46.28 µM -0.345056202867437 0.381954962389474 no 2123 0.365026059312152 693 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2431 5490079 200 µM -0.345557388670325 0.381812845394593 no 2124 0.364837687080225 746 5722345
SGTC_1503 4585-0012 61.3 µM -0.34767013091779 0.381213928344105 no 2125 0.364043965472377 707 2922052
SGTC_2146 5545642 200 µM -0.34990691566216 0.380580157846884 no 2126 0.363204278392545 698 825326
SGTC_3098 9119039 49.47 µM -0.351267429023172 0.380194826624553 no 2127 0.362693863915736 675 17161528
SGTC_127 0180-0333 59.125 µM -0.353621309335015 0.379528430125994 no 2128 0.361811351206711 688 771601
SGTC_1958 st076513 41.9 µM -0.353864796848558 0.379459517849325 no 2129 0.361720105124857 715 732122 YGL099W LSG1
SGTC_2838 9002687 71.43 µM -0.353915760291128 0.37944509456814 no 2130 0.361701007750347 719 6457060
SGTC_2783 7738165 71.43 µM -0.354812271739824 0.379191398251051 no 2131 0.361365117129763 679 17201110
SGTC_1045 1348-1485 165 µM -0.356423371447402 0.378735617355731 no 2132 0.360761764614828 705 6810614
SGTC_1556 plumbagin 1.48 µM -0.356529172066583 0.378705692201507 no 2133 0.360722154671852 705 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_823 0417-1665 178 µM -0.357730723234283 0.378365890776751 no 2134 0.360272419386301 731 3429856
SGTC_3151 9099821 49.47 µM -0.358803783171884 0.378062506450647 no 2135 0.359870941154987 744 17174189
SGTC_1989 st071868 50.2 µM -0.35974455323775 0.37779658604383 no 2136 0.359519085426403 721 16414057
SGTC_604 1000-0114 314 µM -0.360639392640162 0.377543702239723 no 2137 0.359184518622413 722 1572745
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.360896549805815 0.377471038700097 no 2138 0.359088391439435 685 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3255 9139072 49.47 µM -0.361196505008674 0.377386287425453 no 2139 0.358976277316671 694 17646060
SGTC_347 4534-1311 26.2 µM -0.361455516248259 0.377313109472279 no 2140 0.358879476572863 698 2862016
SGTC_190 3970-0790 3.722 µM -0.362118268727337 0.377125883336356 no 2141 0.358631826151901 701 2832352
SGTC_723 4182-0001 115 µM -0.363833888509354 0.376641358727787 no 2142 0.357991027541807 708 744821 YLR208W SEC13
SGTC_2566 crystal violet carbinol 226 nM -0.365385112800539 0.376203429826669 no 2143 0.357411976227558 745 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2764 methyldopa 94.69 µM -0.366647912295228 0.3758470442698 no 2144 0.356940832254751 737 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_478 N-arachidonylglycine 10 µM -0.366835488541314 0.37579411578095 no 2145 0.356870867113446 685 5283389
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.367671671677979 0.375558197983543 no 2146 0.35655903295669 711 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3170 9103054 49.47 µM -0.370455122094433 0.374773220614223 no 2147 0.355521704509245 735 16432970
SGTC_2119 5528445 120.635 µM -0.370545086513919 0.374747857848521 no 2148 0.355488194621362 707 791935
SGTC_2170 morpholine 200 µM -0.371304748758811 0.374533715509624 no 2149 0.355205280690917 708 121171 Reacts with secondary amines.
SGTC_1563 conessine 56.1 µM -0.372471453655178 0.37420490666531 no 2150 0.354770931080141 722 441082 An anti-amoebic, histamine inhibitor.
SGTC_972 1319-0219 195 µM -0.373765846516813 0.373840218974754 no 2151 0.35428926568373 719 23903702
SGTC_1052 3253-3998 198 µM -0.378479292745932 0.372513189202284 no 2152 0.352537286865638 704 5450317
SGTC_69 0096-0274 206.684 µM -0.378519838639803 0.372501780395856 no 2153 0.352522229534059 728 6741392
SGTC_475 α-linolenic acid 10 µM -0.379856352783178 0.372125774631963 no 2154 0.352026024252594 714 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2059 5238311 157 µM -0.381609184472342 0.371632829740786 no 2155 0.35137563534453 697 703021
SGTC_2202 7226349 200 µM -0.385904166884598 0.370425852482364 no 2156 0.349783822248085 689 844334
SGTC_2528 xanthyletin 44.79 µM -0.386820989151543 0.370168371471688 no 2157 0.349444368721605 714 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1111 tnp00062 510.699 nM -0.388334205426139 0.369743526034052 no 2158 0.348884363652006 692 676306
SGTC_3313 9133968 57.047 µM -0.388921853233979 0.369578582861305 no 2159 0.348666977910915 721 1494643
SGTC_1455 4262-0120 131 µM -0.389008258539208 0.369554332321832 no 2160 0.348635018597558 700 1529587
SGTC_1014 4130-3005 69.3 µM -0.389824638157611 0.369325232593123 no 2161 0.348333111808711 727 743608
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.390346049524824 0.369178933761228 no 2162 0.348140338010405 710 368090
SGTC_275 trichlorophene 5.69 µM -0.39065401121487 0.369092534042081 no 2163 0.348026498264828 716 62616
SGTC_340 k038-0059 454 µM -0.39146106753933 0.368866142979544 no 2164 0.347728230415827 699 23733424
SGTC_1772 st048439 82.2 µM -0.391689338634244 0.36880211786022 no 2165 0.347643884209674 698 2927068 YDL195W SEC31
SGTC_3175 9106517 49.47 µM -0.393419971286379 0.368316831282354 no 2166 0.347004660748219 725 41468073
SGTC_2712 st079126 47.7 µM -0.394001282209939 0.368153873006709 no 2167 0.34679004629184 717 3152970
SGTC_984 1492-0255 2.91 µM -0.395707354340581 0.367675748674298 no 2168 0.346160464733364 727 1585198
SGTC_1238 0333-0287 48.8 µM -0.397818928319664 0.367084266953148 no 2169 0.345381831805709 717 7226
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.398285832158991 0.366953523109975 no 2170 0.345209751384036 737 551469
SGTC_1757 st041620 31.8375 µM -0.399737841576355 0.366547025654917 no 2171 0.344674808570228 721 5289815
SGTC_3308 9128332 17.569 µM -0.399837870684475 0.366519027499945 no 2172 0.344637967711295 716 17332805 YDL196W YDL196W
SGTC_1288 0973-0013 65.5 µM -0.400098440958578 0.366446097196031 no 2173 0.344542006237851 711 4315430
SGTC_732 3970-1727 52.7 µM -0.400876783754099 0.366228277679471 no 2174 0.344255421769795 738 1275699
SGTC_3189 9110682 49.47 µM -0.401193623456269 0.366139622310825 no 2175 0.344138787537226 735 17122418
SGTC_3016 9080866 49.47 µM -0.402159722847612 0.365869340792126 no 2176 0.343783241024627 747 17066299
SGTC_3118 9124250 49.47 µM -0.403350757881742 0.365536221603699 no 2177 0.343345103208269 735 1504786
SGTC_2491 paeonol 100 µM -0.408824034282512 0.364006714407035 no 2178 0.341334400330653 736 11092 Increases levels of cortical cytochrome oxidase.
SGTC_547 1120-0019 610 nM -0.409243487624615 0.36388958712982 no 2179 0.341180491649197 724 3676939
SGTC_2605 digitonin 300 nM -0.410446070516533 0.363553850913483 no 2180 0.340739378252489 734 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2512 diallyl trisulfide 49.23 µM -0.411525930586059 0.363252465627019 no 2181 0.340343465673577 738 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_372 0155-0182 15.9 µM -0.411848194920638 0.363162539134022 no 2182 0.340225346924328 719 771486
SGTC_1170 0310-0127 64.8 µM -0.413138652370799 0.362802518086044 no 2183 0.339752515918094 754 774975
SGTC_727 3032-0951 202 µM -0.415953149730063 0.362017730434482 no 2184 0.338722143065983 734 3652836
SGTC_2045 5106652 78.05 µM -0.416146230522073 0.361963913466687 no 2185 0.338651501303518 727 673349
SGTC_826 1683-5028 118 µM -0.417827668776855 0.361495365502453 no 2186 0.338036559815667 737 722377
SGTC_3291 9121177 71.43 µM -0.420704231922754 0.360694266952739 no 2187 0.336985535272863 726 17015612
SGTC_2190 6049624 200 µM -0.421097349254259 0.360584834467328 no 2188 0.336841998559533 748 2265554
SGTC_2739 tacrine 100.86 µM -0.423895186247779 0.359806327884915 no 2189 0.335821127475235 728 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2406 ethylparaben 405.7 µM -0.424914318530353 0.359522895514173 no 2190 0.335449568137824 741 8434 A possible steroid mimic.
SGTC_597 k018-0003 82.8 µM -0.425308635386877 0.35941325219774 no 2191 0.335305849660415 761 6786234
SGTC_194 1486-1323 56.904 µM -0.425564405513326 0.359342139222519 no 2192 0.335212640831726 726 5178754
SGTC_3260 9137109 49.47 µM -0.428089284842219 0.358640396893698 no 2193 0.334293058829207 747 17478346
SGTC_1479 0549-0158 134 µM -0.430304929482889 0.358024993289326 no 2194 0.333486920867822 731 5440202
SGTC_2225 6654152 15.4 µM -0.430784885982811 0.35789173210748 no 2195 0.333312395086478 747 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.432664324367103 0.357370067909724 no 2196 0.332629325622148 752 1273210
SGTC_1716 st033144 30.6155 µM -0.433508281876405 0.357135902415579 no 2197 0.332322775363298 767 674617
SGTC_2879 9041815 71.43 µM -0.434618956231622 0.356827815337058 no 2198 0.331919516599596 728 4942971
SGTC_1407 3909-7909 12.3 µM -0.434992152588105 0.356724316313464 no 2199 0.331784061768753 718 4411780
SGTC_818 4072-2707 53.5 µM -0.43704388618302 0.356155494980131 no 2200 0.331039760533524 721 882871
SGTC_442 cape 100 µM -0.438343187568969 0.355795442862197 no 2201 0.330568761709431 737 5281787
SGTC_1093 fluphenazine 7.97 µM -0.439732776534629 0.355410513280685 no 2202 0.330065330286957 754 6602611 An atypical antipsychotic.
SGTC_2458 5808907 16.39 µM -0.439873802761618 0.355371455887149 no 2203 0.330014255351377 759 2731747
SGTC_2492 derrusnin 100 µM -0.440792016111331 0.355117192686468 no 2204 0.329681786999373 760 1715307 Part of coumarin class of compounds.
SGTC_6 0844-0013 19.835 µM -0.441822491118722 0.354831919829878 no 2205 0.329308830968775 749 1584900
SGTC_2046 4110841 106 µM -0.44198559555975 0.354786774060558 no 2206 0.329249814731608 756 44119630 YMR134W ERG29
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.444020808736015 0.354223617929745 no 2207 0.328513769732587 728 676296 Flavone; oxidizing agent.
SGTC_2425 5628681 7.85 µM -0.444067822990439 0.354210612554294 no 2208 0.328496774640003 746 5714958
SGTC_350 k064-0020 19.8 µM -0.444393390849166 0.3541205566149 no 2209 0.328379095477156 752 2790705
SGTC_1502 4534-4282 27.7 µM -0.446724896837053 0.3534758730363 no 2210 0.327536851699553 758 3278949
SGTC_2010 4012422 159 µM -0.449880506735504 0.352603986237798 no 2211 0.326398301989784 731 952393
SGTC_180 1486-1293 102.781 µM -0.450442569586694 0.352448770787451 no 2212 0.326195677911823 747 4140536
SGTC_305 1682-2595 20.8 µM -0.450528843699107 0.352424948090226 no 2213 0.326164580569439 748 226033
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.451903182303231 0.352045532853327 no 2214 0.325669365903009 764 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1811 st050069 61.5 µM -0.452390688954184 0.351910981693359 no 2215 0.325493776739768 750 3877702
SGTC_2877 9040724 71.43 µM -0.452440924729582 0.35189711774252 no 2216 0.32547568511944 746 6463895
SGTC_2340 7987427 183.45 µM -0.455026738993431 0.351183757119762 no 2217 0.324545001134509 748 2239331
SGTC_2299 7976368 114.88 µM -0.455058408788789 0.351175023469187 no 2218 0.324533609343677 739 2979718
SGTC_2602 kawain 100 µM -0.455811926446444 0.350967247405119 no 2219 0.324262613548701 746 5369129
SGTC_2938 9059746 27.26 µM -0.456720791587728 0.350716694878866 no 2220 0.323935872267712 752 6471769
SGTC_981 1488-1094 54.9 µM -0.457748991723257 0.350433322791835 no 2221 0.323566392985024 728 3449522
SGTC_2151 5563267 85.4165 µM -0.458969938186273 0.350096937885809 no 2222 0.323127876965151 756 5310824
SGTC_1253 0550-0034 176 µM -0.462826388452689 0.349035214459685 no 2223 0.321744407346059 716 5969915
SGTC_616 4092-0450 108 µM -0.463982999457233 0.348717016429714 no 2224 0.321329962904608 750 787165
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.464079042261255 0.348690598644311 no 2225 0.321295558209539 743 2374 Ca(2+)-ATPase inhibitor.
SGTC_391 gliotoxin 8.33 µM -0.465692269184538 0.348246969967187 no 2226 0.320717893393411 755 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1275 0867-0008 21.1 µM -0.46639369381542 0.348054146691143 no 2227 0.320466862283762 749 3422836
SGTC_318 1488-0629 67.2 µM -0.469385316041868 0.347232184284804 no 2228 0.319397121167224 767 3662576
SGTC_2618 avocadyne 43.43 µM -0.472469932799055 0.346385423001387 no 2229 0.318295699063532 756 3015189
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.472629193384501 0.346341725007659 no 2230 0.318238875466279 768 91467 include heat shock
SGTC_1940 st075990 51.1 µM -0.475183082204033 0.345641267521929 no 2231 0.317328242207653 760 1084979
SGTC_1724 st037281 8.293 µM -0.476919624707423 0.345165285854071 no 2232 0.316709678449028 727 574124 YDL195W SEC31
SGTC_1364 1653-0028 37.6 µM -0.477371248687517 0.345041537013001 no 2233 0.316548891931419 752 5718652
SGTC_1741 st038134 10.228 µM -0.478530139926513 0.344724066724607 no 2234 0.316136463789547 768 1272587
SGTC_308 4092-1169 104 µM -0.478869486335667 0.344631125789713 no 2235 0.316015739886046 760 2268590 YDL196W YDL196W
SGTC_377 3970-0964 33.1 µM -0.479132144243701 0.344559194906643 no 2236 0.315922311704471 754 16481235
SGTC_2616 abietic acid 100 µM -0.479841462889617 0.344364970643402 no 2237 0.315670063760388 770 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1571 st070080 73.4 µM -0.480989482943107 0.344050708976084 no 2238 0.315261986730156 741 4315245
SGTC_3127 9126946 49.47 µM -0.482534788699325 0.343627863457338 no 2239 0.314713045666896 764 27243249
SGTC_2456 5770359 74.46 µM -0.485047905161324 0.342940611557664 no 2240 0.313821182150962 782 3118787
SGTC_658 3253-0951 102 µM -0.485053226423098 0.342939156923695 no 2241 0.313819294874259 753 1184878
SGTC_861 0443-0273 110 µM -0.485394848031262 0.34284577522486 no 2242 0.313698143111716 746 6149169
SGTC_114 0364-0001 490.298 µM -0.486097257355847 0.342653802970975 no 2243 0.313449105694583 749 4003655
SGTC_406 estrone 100 µM -0.487795235458713 0.342189904308115 no 2244 0.312847443275334 761 5870 A steroid.
SGTC_119 0121-0043 24.815 µM -0.487871579730744 0.342169052143714 no 2245 0.312820403099438 777 1092378
SGTC_1206 3978-0017 132 µM -0.490438336419957 0.341468265818657 no 2246 0.31191187722871 774 3873677
SGTC_260 nsc-65238 3.989 µM -0.490862641836532 0.341352472777665 no 2247 0.311761800599074 743 3246252
SGTC_158 k038-0087 26.446 µM -0.49106243041392 0.341297955601926 no 2248 0.311691146293192 710 X158
SGTC_525 k781-2675 26.7 µM -0.491242304005765 0.341248875547845 no 2249 0.311627540759231 745 3651118 YDL195W SEC31
SGTC_2135 5326629 150.42 µM -0.491250708134225 0.341246582474887 no 2250 0.311624569092541 738 5020077
SGTC_1122 capsaicin 818.572 nM -0.491419582072764 0.341200506332472 no 2251 0.311564858534029 776 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1457 k015-0032 57.3 µM -0.491952426595183 0.341055138735807 no 2252 0.311376487505632 779 4302660
SGTC_264 promethazine 12.5 mM -0.492024094429431 0.341035588526337 no 2253 0.311351155281319 783 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3093 9117344 49.47 µM -0.493174627056042 0.340721794133723 no 2254 0.310944602148848 724 24824913
SGTC_3216 9129716 49.47 µM -0.496904569598423 0.33970525430425 no 2255 0.309628174479835 736 8056934
SGTC_2656 pseudo-anisatin 100 µM -0.497360875794465 0.339580974720234 no 2256 0.309467295073557 777 6708809 A neurotoxin.
SGTC_2266 7929956 200 µM -0.497426416388632 0.339563125512074 no 2257 0.309444190491484 768 2967153
SGTC_155 k072-0202 43.6 µM -0.497526828534853 0.339535780145794 no 2258 0.309408794338206 776 5857737
SGTC_3057 9095946 49.47 µM -0.499141663427545 0.339096126245828 no 2259 0.308839794089301 761 24540043
SGTC_2788 5282734 71.43 µM -0.50041510503271 0.338749574285072 no 2260 0.308391409806438 787 743706
SGTC_444 curcumin 90.4 µM -0.501731324903116 0.338391524136297 no 2261 0.307928263314156 756 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1708 st033234 31.827 µM -0.503572494989306 0.337890917350139 no 2262 0.307280912441303 752 674664
SGTC_2221 6807166 181.081 µM -0.504026727313326 0.337767457437578 no 2263 0.307121297670384 748 674925
SGTC_2116 5511452 16.8835 µM -0.50450048523075 0.337638709082657 no 2264 0.306954860640995 783 870744
SGTC_1802 st050112 57.9 µM -0.504842555691703 0.337545759895036 no 2265 0.306834711773858 748 4662563
SGTC_112 phenothiazine 287.218 µM -0.505133733778559 0.337466647259404 no 2266 0.306732454696033 787 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1630 st005209 31.3 µM -0.507846475184841 0.336729945246765 no 2267 0.305780506975899 765 3367314
SGTC_2312 7706453 155.7 µM -0.508066007678009 0.336670353924884 no 2268 0.305703526490918 749 976098
SGTC_843 0310-0051 143 µM -0.509293261456318 0.336337295790282 no 2269 0.305273340270113 783 2065037
SGTC_1351 1496-0003 46.5 µM -0.509907252857977 0.336170715969524 no 2270 0.30505822023647 767 3891978
SGTC_1023 4482-3888 16 µM -0.512390976641153 0.335497194224846 no 2271 0.304188702435155 763 3303168
SGTC_3080 9117754 49.47 µM -0.513881143539778 0.335093352849718 no 2272 0.303667545875122 786 9550191
SGTC_968 1309-0633 340 µM -0.513950247572118 0.335074629991769 no 2273 0.303643387771445 785 3761976
SGTC_980 1473-0395 201 µM -0.520083096730226 0.333414649307864 no 2274 0.301502829584327 778 768876
SGTC_3128 9127691 49.47 µM -0.521353924830668 0.33307108007492 no 2275 0.301060121080496 778 41316314
SGTC_611 3453-1652 23.7 µM -0.52320776986546 0.332570143058772 no 2276 0.30041483750037 782 1560575
SGTC_2404 5161160 200 µM -0.52496408855387 0.332095834768485 no 2277 0.299804077804032 782 2831543
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.525670595488535 0.331905112557504 no 2278 0.299558548743168 751 4330530
SGTC_3176 9106582 49.47 µM -0.526069698123332 0.331797393671643 no 2279 0.299419890756954 755 17018027
SGTC_125 0133-0007 11.75 µM -0.530564313953544 0.330585246467953 no 2280 0.297860365224999 782 26541
SGTC_3262 9137218 49.47 µM -0.531716115551305 0.330274903747166 no 2281 0.297461314289949 752 17650664
SGTC_734 2023-0417 80 µM -0.532294833296634 0.330119017425772 no 2282 0.297260905061837 784 3935732
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.532309061201196 0.330115185297153 no 2283 0.297255978733598 784 1377
SGTC_2073 5212005 126 µM -0.533670950236699 0.329748458112188 no 2284 0.296784605480297 789 691789
SGTC_122 0236-0016 402.397 µM -0.534910092265862 0.32941492617536 no 2285 0.296356014624533 787 6808838
SGTC_3307 9126885 69.2785 µM -0.534952102458039 0.329403620936995 no 2286 0.296341489235487 761 24824909
SGTC_2282 7944268 200 µM -0.536898034629175 0.328880127950815 no 2287 0.295669024332401 803 2970414
SGTC_567 1080-0542 68.4 µM -0.538091123009284 0.3285593301911 no 2288 0.295257070323152 738 5950415
SGTC_1522 st012842 45.6 µM -0.538226416903587 0.328522960321296 no 2289 0.29521037222484 783 3491067 YOR116C RPO31
SGTC_1866 st057638 64 µM -0.539307273059523 0.328232461607019 no 2290 0.294837425597685 764 688802
SGTC_1028 k015-0029 4.8 µM -0.539665450856271 0.328136218051783 no 2291 0.294713885201437 786 4588309
SGTC_1088 bifonazole 369 nM -0.540886975216624 0.327808076257084 no 2292 0.294292744467349 772 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2052 5265182 7.135 µM -0.542932148180616 0.32725897288476 no 2293 0.293588260198873 775 1239884
SGTC_221 trifluoperazine 10.304 µM -0.543659034884704 0.327063902821244 no 2294 0.293338063594458 792 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2118 5526350 200 µM -0.545435614273484 0.326587332159614 no 2295 0.292726975834179 781 743594
SGTC_2998 9066762 71.4286 µM -0.547983329982759 0.32590439655917 no 2296 0.291851674604047 785 4945196
SGTC_1222 0366-0074 1.18 µM -0.548422738393083 0.325786668568101 no 2297 0.291700833426635 784 286520
SGTC_1391 3442-0225 151 µM -0.550169968407769 0.325318715935449 no 2298 0.291101399892084 760 5227075
SGTC_2751 anetholtrithion 17.25 µM -0.55143021133989 0.324981361667928 no 2299 0.290669397625123 779 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_588 3970-1144 52.9 µM -0.551980634889755 0.324834063851495 no 2300 0.290480810501651 752 1888707
SGTC_3027 9089541 49.47 µM -0.552945481111624 0.324575929239837 no 2301 0.290150371374677 777 9943819
SGTC_98 0074-0023 107.663 µM -0.553357565997035 0.324465705865346 no 2302 0.290009294843341 792 3563821
SGTC_424 splitomicin 100 mM -0.55399147777186 0.324296178842577 no 2303 0.289792339073875 790 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_477 mead ethanolamide 10 µM -0.554015176228523 0.324289841870349 no 2304 0.289784229773886 752 16061185
SGTC_1637 st007924 17.4 µM -0.554103409906479 0.324266248614064 no 2305 0.289754038306643 781 683336
SGTC_2669 eugenol 100 µM -0.555194262804186 0.323974618165489 no 2306 0.289380896356423 773 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3104 9120930 49.47 µM -0.556196121297974 0.323706874768561 no 2307 0.289038395241632 797 17014836
SGTC_1629 st005085 44.9 µM -0.556248355253391 0.323692917916022 no 2308 0.289020543471901 787 24207091
SGTC_3328 9140624 29.0385 µM -0.556526595722558 0.323618576562857 no 2309 0.288925459188695 796 4904392
SGTC_1184 1269-1718 139 µM -0.556992156527716 0.323494201987875 no 2310 0.288766394069887 770 5403821
SGTC_1091 telmisartan 47.6 µM -0.557125361402004 0.323458619931251 no 2311 0.288720890417863 804 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_301 4119-0100 24.5 µM -0.557698558017191 0.32330552448007 no 2312 0.288525121259481 791 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2784 7567673 72.73 µM -0.558247199625727 0.323159015461273 no 2313 0.288337797208143 784 3471247
SGTC_1306 1185-0270 9.02 µM -0.558734499290499 0.323028910166045 no 2314 0.288171465388377 789 1548076
SGTC_1433 4060-0023 7.6 µM -0.56047978431824 0.322563110089475 no 2315 0.287576112413927 774 3840627
SGTC_2925 9010536 32.5 µM -0.561379168446828 0.322323181598341 no 2316 0.287269540998128 772 2994177
SGTC_2358 9037157 4 µM -0.561660148375159 0.322248239815268 no 2317 0.287173795602592 784 2388925
SGTC_2306 7482397 179.52 µM -0.561978019489149 0.322163467280615 no 2318 0.28706549755554 802 891448
SGTC_197 4544-0043 41.561 µM -0.562919895818285 0.321912334128284 no 2319 0.286744715798567 789 896523
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.563198441979939 0.321838080742911 no 2320 0.286649881850477 777 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2519 cryptotanshinone 88.04 µM -0.564610522352642 0.321461765207826 no 2321 0.286169353314258 784 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2386 9075165 157.42 µM -0.565196109923726 0.321305761437746 no 2322 0.285970191164278 780 16452277
SGTC_3253 9135987 49.47 µM -0.567600722456487 0.320665490070392 no 2323 0.285153058239092 781 4182430
SGTC_687 k029-0044 34.9 µM -0.567705369808949 0.320637637922743 no 2324 0.285117522368495 790 5829338
SGTC_2167 5876490 200 µM -0.569001183486226 0.320292837668049 no 2325 0.284677668394327 807 686534
SGTC_284 0988-0104 32.6 µM -0.569229233689151 0.320232172324713 no 2326 0.284600292042807 803 4666532
SGTC_672 1441-0018 53.7 µM -0.569357955678613 0.320197932145042 no 2327 0.284556621717087 759 251141
SGTC_2280 7785178 200 µM -0.570031906066333 0.320018685657083 no 2328 0.284328029021883 770 2954328
SGTC_1443 4112-3303 14 µM -0.570172065974057 0.319981413453382 no 2329 0.284280500152741 800 704433
SGTC_1004 4084-0029 199 µM -0.570372802055865 0.319928035617471 no 2330 0.284212436239754 769 716894 YLR208W SEC13
SGTC_2058 5236698 133 µM -0.57098763838187 0.31976456737039 no 2331 0.284004011170805 759 766665
SGTC_1676 st018489 23.4 µM -0.571707616279655 0.319573189332872 no 2332 0.283760036866227 789 3696235
SGTC_2893 9048488 25.97 µM -0.573218570381924 0.31917171736739 no 2333 0.283248356066642 771 6467338
SGTC_2155 5570423 76 µM -0.573420539415475 0.3191180687146 no 2334 0.283179993309095 795 797402
SGTC_1462 k081-0014 26.5 µM -0.57487453598995 0.318731958210036 no 2335 0.282688076304518 781 3270634
SGTC_1248 0469-0687 58.6 µM -0.575067697154871 0.318680678827341 no 2336 0.282622756814204 787 4017482
SGTC_2154 5570129 200 µM -0.575967862005376 0.318441753729539 no 2337 0.282318452266777 817 673366
SGTC_2607 solasodine 47.35 µM -0.579234148907517 0.317575438224833 no 2338 0.281215595862124 781 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1829 berberine 14.4 µM -0.579314833685493 0.317554050857416 no 2339 0.281188379130127 794 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3199 9111318 49.47 µM -0.579614557563844 0.317474607440965 no 2340 0.281087286882494 779 8548020
SGTC_2789 5281112 71.43 µM -0.580195363829811 0.317320685564942 no 2341 0.280891439865737 774 765948
SGTC_448 monastrol 171 µM -0.580731810692169 0.317178547618866 no 2342 0.280710609392044 800 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2638 epoxomicin 18 µM -0.582259066904247 0.316774030727612 no 2343 0.280196096296032 784 9915668 A protesome inhibitor.
SGTC_735 3076-0345 636 µM -0.584026657432939 0.316306131040249 no 2344 0.279601188637957 786 2888990
SGTC_1439 4092-1168 46 µM -0.585181047554779 0.316000710528446 no 2345 0.279212993537866 803 2886240
SGTC_3147 9097027 49.47 µM -0.586585798641446 0.315629220597122 no 2346 0.278740961375616 810 25236841
SGTC_851 0394-0702 453 µM -0.586913015622814 0.315542713976645 no 2347 0.278631063939388 806 762646
SGTC_2092 5303694 80.6725 µM -0.588681197046964 0.315075433383608 no 2348 0.278037576817142 795 1963699
SGTC_1861 st057647 17.4 µM -0.589567367325866 0.31484135473213 no 2349 0.277740367442363 795 688668
SGTC_2588 indole-3-carbinol 100 µM -0.590802223294218 0.314515296054288 no 2350 0.277326472575613 804 3712 Induces cell cycle arrest.
SGTC_1831 st055328 12 µM -0.594180082229062 0.313624125620318 no 2351 0.276195836545627 794 1103068
SGTC_1610 st001799 48.1 µM -0.594555677308686 0.313525100526814 no 2352 0.276070257359852 794 621897
SGTC_569 4130-2812 160 µM -0.595156236192453 0.313366791978176 no 2353 0.275869520409337 810 743552
SGTC_2188 6126565 140.678 µM -0.595482388356704 0.313280832004981 no 2354 0.275760534025432 791 874518
SGTC_1625 st003711 30.1 µM -0.595989663350962 0.313147155841127 no 2355 0.275591066044628 786 24207034 YER133W GLC7
SGTC_1961 st076550 68.7 µM -0.597274464825847 0.312808697218788 no 2356 0.275162075017171 797 1579337
SGTC_888 0916-0002 6.97 µM -0.599124444707284 0.312321629302411 no 2357 0.27454495092563 777 2802138 YIL048W NEO1
SGTC_1795 st049545 62.3 µM -0.600172740869195 0.312045776361511 no 2358 0.274195559225683 747 5291882
SGTC_2986 9022445 71.43 µM -0.600527928763667 0.311952334656563 no 2359 0.274077226764461 817 6459286
SGTC_200 k038-0079 37.545 µM -0.605715788542654 0.310588910609027 no 2360 0.272351748954778 812 3436683
SGTC_2461 5755302 26.15 µM -0.609354873147769 0.309634069703555 no 2361 0.271144621301317 827 2788904
SGTC_1753 st043925 64 µM -0.609884393945445 0.309495238239 no 2362 0.270969195555454 804 670181
SGTC_2427 5545055 42.75 µM -0.610608652517522 0.309305393817026 no 2363 0.270729346565712 793 5372858
SGTC_1987 st072290 61.9 µM -0.612344921906821 0.308850485976938 no 2364 0.270154787146952 802 54697379
SGTC_1924 st058459 75.1 µM -0.612762732237125 0.308741062127789 no 2365 0.270016618096185 798 688683
SGTC_2345 9052315 157.45 µM -0.613555607486043 0.308533456069342 no 2366 0.269754513076862 791 6469265
SGTC_2705 st078069 42.8 µM -0.614396440875969 0.308313359534876 no 2367 0.269476693555211 800 1530061
SGTC_1330 1469-0054 61.8 µM -0.615519099552061 0.308019599817229 no 2368 0.269105979926701 804 7102664
SGTC_1055 3448-0672 86 µM -0.616096065943595 0.307868676122412 no 2369 0.26891555919782 795 748378
SGTC_2142 5622915 118.518 µM -0.617263348177842 0.307563436162154 no 2370 0.268530518918633 795 5322196
SGTC_429 1112-0049 25.5 µM -0.617303778153008 0.307552866259424 no 2371 0.268517187634849 779 2836170
SGTC_1636 st007707 68.9 µM -0.617505019775334 0.307500256574199 no 2372 0.268450835651201 821 403051
SGTC_1979 st071809 45.3 µM -0.618184787895191 0.307322577157092 no 2373 0.268226768221479 828 4976333
SGTC_52 0329-0193 875 nM -0.61999591479018 0.30684940127059 no 2374 0.267630238256235 827 3739292
SGTC_656 4090-1979 187 µM -0.620443224355722 0.306732586453163 no 2375 0.267483011169913 799 22330961
SGTC_1674 st016616 23.6 µM -0.621539826396315 0.306446292068428 no 2376 0.2671222494003 800 625830
SGTC_205 1486-1330 71.903 µM -0.622051192582897 0.306312827970541 no 2377 0.266954103413073 807 4118834
SGTC_571 k831-0106 44.2 µM -0.623577717445841 0.305914565268612 no 2378 0.266452474020986 831 4783639
SGTC_1620 st003704 16.5 µM -0.623975524739929 0.305810816991824 no 2379 0.266321829438065 805 2834414
SGTC_487 nimodipine 119 µM -0.624123403934108 0.305772254020502 no 2380 0.266273272442019 795 4497 L-type voltage-gated calcium channels inhibitor
SGTC_334 1502-1024 68.5 µM -0.624293205624542 0.305727976899854 no 2381 0.266217522593597 808 3296216
SGTC_1371 2421-0008 32.7 µM -0.624581879814089 0.305652709362565 no 2382 0.266122757699747 811 2827552
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.625888515136239 0.305312126204355 no 2383 0.26569403404366 817 689007
SGTC_2148 5546263 113.568 µM -0.627881681957817 0.304792918619355 no 2384 0.265040725889418 796 792097
SGTC_1746 st038117 42 µM -0.629070817692249 0.304483343182797 no 2385 0.264651347232404 804 2898218
SGTC_1301 naphtanilide LB 4.81 µM -0.629729428106823 0.3043119430846 no 2386 0.264435812647913 816 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_534 k292-0788 63.4 µM -0.630860188496983 0.304017768546433 no 2387 0.264065972359672 826 4146317
SGTC_1628 st004252 77.7 µM -0.633930767346643 0.30321957814676 no 2388 0.263063002653796 792 692968
SGTC_2959 9079155 11 µM -0.635145264075595 0.302904131122417 no 2389 0.262666839061225 829 16189457
SGTC_206 4546-0025 72.014 µM -0.636007886580184 0.302680167332948 no 2390 0.262385640841229 834 6620745 YIL048W NEO1
SGTC_2553 4-methylesculetin 85.09 µM -0.637546135203098 0.302280974091177 no 2391 0.261884584417092 807 5319502
SGTC_1376 2910-0861 41.3 µM -0.64036096982615 0.30155110441992 no 2392 0.260968975579126 828 1112859
SGTC_2252 omeprazole 400 µM -0.640374338759623 0.301547639828377 no 2393 0.260964630866062 801 4594 A proton pump inhibitor.
SGTC_1157 4092-0394 27.6 µM -0.640545722884267 0.301503226803138 no 2394 0.26090893676027 813 3659885
SGTC_853 0419-0306 21 µM -0.640750087195161 0.301450271035818 no 2395 0.260842533189247 816 762713
SGTC_1948 st076329 66.6 µM -0.641714985438204 0.301200298975934 no 2396 0.260529128745401 809 24208413
SGTC_1931 st074438 57.1 µM -0.641970992432055 0.301133992016644 no 2397 0.260446008772746 843 2787313
SGTC_739 1486-1183 203 µM -0.644522589827524 0.300473476645367 no 2398 0.25961830695814 801 4346692
SGTC_2711 st079103 59.1 µM -0.644636162928596 0.300444091935221 no 2399 0.259581497056615 808 54693780
SGTC_3085 9117376 49.47 µM -0.645944881231601 0.300105581627936 no 2400 0.259157526064187 815 16480349
SGTC_173 1273-0061 2.693 µM -0.648155568857624 0.299534162017152 no 2401 0.258442167975496 815 2847414 YPL266W DIM1
SGTC_2585 alliin 100 µM -0.654143063696327 0.297988993736301 no 2402 0.256509819690912 831 87310 A garlic compound which reacts with lipids.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.655265726315512 0.297699677729695 no 2403 0.256148341758288 819 756377
SGTC_17 0960-0276 49.807 µM -0.656722787824502 0.29732437662057 no 2404 0.255679589588928 816 6821114
SGTC_2153 5569715 200 µM -0.659302239835028 0.296660507575934 no 2405 0.254850852193907 815 2054701
SGTC_298 1391-0729 10 µM -0.659586002951223 0.296587517426375 no 2406 0.254759769485031 825 3237558
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.662018892232078 0.295962062408784 no 2407 0.253979557057973 850 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1835 st008666 49.2 µM -0.662795911164748 0.295762431543403 no 2408 0.253730636354398 816 690455
SGTC_1770 st043884 66.3 µM -0.663709086436372 0.295527898648584 no 2409 0.253438261319512 837 670149
SGTC_3045 9092950 49.47 µM -0.665939316748623 0.294955463284908 no 2410 0.252724944349539 817 44120432
SGTC_2377 9073351 62.6 µM -0.667544727744299 0.294543717416099 no 2411 0.252212124804163 846 7337946 YHR072W ERG7
SGTC_762 1165-0429 115 µM -0.667661530456967 0.294513770932994 no 2412 0.252174835714091 822 5967793
SGTC_1750 st081859 2.357 µM -0.667691530510824 0.294506079590944 no 2413 0.252165258711424 829 5291695
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.667798864307641 0.294478562368011 no 2414 0.252130995808645 811 88881 An O-methylated flavonoid and antioxidant.
SGTC_2184 6075246 200 µM -0.667906026460807 0.294451090333348 no 2415 0.252096790147546 819 2267320
SGTC_1714 st033236 13.627 µM -0.67101987427807 0.293653343045903 no 2416 0.251103934380692 831 2916566
SGTC_1793 st048256 72.231 µM -0.673623719748781 0.292987024083361 no 2417 0.250275284545946 827 672022
SGTC_3167 9103034 49.47 µM -0.674423221451992 0.292782574017002 no 2418 0.250021141750609 823 5127859
SGTC_592 k241-0073 46.5 µM -0.675688143655172 0.292459241134191 no 2419 0.249619332593217 826 4230158
SGTC_1325 1431-0015 227 µM -0.677199181897186 0.292073215051484 no 2420 0.24913979337933 810 1103340
SGTC_689 0833-0039 98 µM -0.677545933030315 0.29198466374582 no 2421 0.249029818496663 864 5374726
SGTC_2096 5468907 200 µM -0.677941040421332 0.291883778737223 no 2422 0.248904538531982 818 759785
SGTC_2661 dactinomycin 12.96 µM -0.679497535540522 0.291486508068204 no 2423 0.248411334310547 825 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.680351307387004 0.291268703520654 no 2424 0.248141022312437 843 688751
SGTC_2936 9038235 15.59 µM -0.681103663985455 0.291076833865878 no 2425 0.247902949416821 826 4749415
SGTC_3103 9120822 49.47 µM -0.681944216851173 0.290862541816813 no 2426 0.247637112278544 842 17141819
SGTC_2292 7671323 168.05 µM -0.68359941907339 0.290440777328865 no 2427 0.247114075806867 852 937504
SGTC_2077 5212015 200 µM -0.687022722792246 0.289569389877952 no 2428 0.246034204730452 831 780900
SGTC_371 0195-0006 7.36 µM -0.687697117793118 0.289397870325623 no 2429 0.24582176769924 821 3928593
SGTC_832 4083-0019 164 µM -0.688966194687543 0.289075234217529 no 2430 0.245422270698608 839 1990758
SGTC_2606 farnesol 9.78 µM -0.690591980466467 0.288662159729475 no 2431 0.244910994296451 851 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3316 9136639 10.545 µM -0.692252618616514 0.288240517291318 no 2432 0.24438934983688 822 4903665
SGTC_1558 st069300 45.6 µM -0.694982629599576 0.287547988970373 no 2433 0.243533093737691 825 24208000
SGTC_289 k017-0060 526 µM -0.696636523806584 0.287128824727333 no 2434 0.243015146263409 842 5512909
SGTC_1386 3228-0095 33.8 µM -0.69868474529529 0.286610123198714 no 2435 0.242374534675815 830 870181
SGTC_3348 9149464 3.537 µM -0.699204932853144 0.286478459185364 no 2436 0.242211984138592 825 1951442
SGTC_2595 hexamethylquercetagetin 100 µM -0.701667106408278 0.285855651285826 no 2437 0.241443395552976 853 386331
SGTC_373 0844-0104 25.9 µM -0.702213470860377 0.285717535486923 no 2438 0.241273022983559 828 5375804
SGTC_733 4069-0007 56.1 µM -0.705361480497251 0.284922367268121 no 2439 0.240292654481256 839 5717425 YNL287W SEC21
SGTC_1129 3453-1384 223 µM -0.705754675409831 0.284823122811442 no 2440 0.240170356466185 855 1084452
SGTC_954 1189-0853 2.85 µM -0.705870557395455 0.284793876738188 no 2441 0.24013431939911 838 2828194
SGTC_1509 1326-1131 80 µM -0.707710973947747 0.284329588152932 no 2442 0.239562380586301 808 768313
SGTC_505 gw-5074 63.9 µM -0.708226978720612 0.284199478711468 no 2443 0.239402157450777 837 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1804 st050076 49.1 µM -0.708428572778961 0.284148654958189 no 2444 0.239339576970658 843 3895976
SGTC_2968 9090663 33.37 µM -0.709124742663333 0.283973177429272 no 2445 0.239123534934893 853 25236811
SGTC_471 1-acyl-paf 4 µM -0.712263017546744 0.283182783998226 no 2446 0.238150960224246 830 16759367
SGTC_1838 st055369 84.5 µM -0.714896031813713 0.282520458785397 no 2447 0.23733664460132 827 676036
SGTC_2726 cimetidine 79.27 µM -0.717765952395516 0.281799390090736 no 2448 0.236450805005512 848 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_103 0844-0104 51.839 µM -0.719439277866267 0.281379376140781 no 2449 0.235935151635405 856 5375804
SGTC_336 4111-0029 111 µM -0.71999479069398 0.281240006177982 no 2450 0.235764101473683 847 3131175
SGTC_2695 st077686 51.995 µM -0.721675943253868 0.280818433018079 no 2451 0.23524686793998 848 2876092
SGTC_652 0437-0092 114 µM -0.722048176274085 0.280725131572141 no 2452 0.235132429263381 829 3091274
SGTC_1188 1403-0014 4.57 µM -0.723758656186027 0.280296586934373 no 2453 0.234606957742575 837 9614867
SGTC_1485 3909-9022 254 µM -0.724112791999795 0.280207901147657 no 2454 0.234498245926445 853 714516
SGTC_2360 9040895 200 µM -0.724552094811497 0.280097905991797 no 2455 0.234363428472545 839 4914414
SGTC_1916 st067606 49.2 µM -0.72465764382788 0.280071481142394 no 2456 0.23433104297184 821 19590279
SGTC_3240 9133527 49.47 µM -0.727507184385473 0.279358538056458 no 2457 0.233457657922444 852 17617455
SGTC_526 4469-0568 170 µM -0.731389864809141 0.278388529108752 no 2458 0.232270527074352 845 2901964
SGTC_2176 5809774 33.9695 µM -0.731516176910111 0.278357000181264 no 2459 0.23223196360102 822 2870539
SGTC_2089 5281248 129.67 µM -0.731793024026681 0.278287902101265 no 2460 0.23214745378731 844 2737878
SGTC_1939 st074455 53.6 µM -0.73184985903904 0.278273717724511 no 2461 0.232130106559622 849 1644229
SGTC_1621 st003705 32.4 µM -0.733744977713823 0.27780095279318 no 2462 0.231552090235852 847 24207032
SGTC_374 0880-0231 82.3 µM -0.735096586560291 0.277464014060238 no 2463 0.231140336521826 852 6833587
SGTC_84 0443-0269 128.823 µM -0.735549555900547 0.277351139325493 no 2464 0.231002435541331 833 6150058
SGTC_2947 9072639 7.68 µM -0.735622730147308 0.277332907253979 no 2465 0.230980162845665 886 16488146
SGTC_1262 0737-0114 49.6 µM -0.737283439687263 0.276919283065162 no 2466 0.230475000393602 843 765919
SGTC_416 estradiol valerate 100 µM -0.73872406979336 0.276560717744447 no 2467 0.23003728341806 859 13791 A steroid.
SGTC_390 dec-rvkr-cmk 16.7 µM -0.739516580968781 0.276363562933293 no 2468 0.229796687548931 843 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2439 5492030 7.2 µM -0.739857135930507 0.276278863482366 no 2469 0.229693342883563 854 5722370
SGTC_3251 9135047 49.47 µM -0.740516844621309 0.276114823525552 no 2470 0.229493222034712 830 17682963
SGTC_2173 5763948 167 µM -0.743051136882924 0.275485103729323 no 2471 0.228725360600801 851 2867177
SGTC_2999 9069765 71.4286 µM -0.744518710856455 0.275120764888798 no 2472 0.22828136290246 825 2097066
SGTC_2957 9076800 11.52 µM -0.744519238670323 0.275120633896813 no 2473 0.228281203305615 862 16459615
SGTC_2172 5754775 163.918 µM -0.746234972774974 0.274694988200126 no 2474 0.227762742613103 844 2263357
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.746261898448891 0.274688310967791 no 2475 0.227754611495708 835 77254
SGTC_3084 9116877 49.47 µM -0.746955564576038 0.274516317990888 no 2476 0.227545191890669 838 27241325
SGTC_280 3448-3607 3.04 µM -0.749008221992896 0.274007677610232 no 2477 0.226926124914961 822 626179
SGTC_994 3910-0338 138 µM -0.749869951092244 0.273794283444638 no 2478 0.226666516880851 847 3479481
SGTC_993 3909-8757 62.7 µM -0.750057182036258 0.273747929406516 no 2479 0.226610133094554 844 4288324 YLR208W SEC13
SGTC_806 3966-4455 5.86 µM -0.752596594933208 0.273119613295666 no 2480 0.225846182214895 847 714982
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.752622298067945 0.273113257333975 no 2481 0.225838457198571 837 688664
SGTC_1820 st053765 18.6 µM -0.753896519266642 0.27279825535421 no 2482 0.225455680412394 847 3690829
SGTC_1504 k297-0033 30 µM -0.756491840812528 0.272157220251518 no 2483 0.22467718124706 804 4388117
SGTC_3333 9141820 12.094 µM -0.756565722608286 0.272138982680097 no 2484 0.224655041820432 848 1939433
SGTC_3140 9094243 49.47 µM -0.758060665647655 0.271770089588973 no 2485 0.224207332951776 865 19291112
SGTC_556 4058-0063 51.5 µM -0.758112413328805 0.271757324756054 no 2486 0.224191844518756 862 6615692
SGTC_1602 st001878 87.6 µM -0.759841414224974 0.271330995962838 no 2487 0.22367469220588 860 595405 YLR310C CDC25
SGTC_2327 6189656 200 µM -0.760744304652116 0.27110849809848 no 2488 0.223404903241677 870 5349088
SGTC_370 0180-0345 38.7 µM -0.762637518275669 0.270642252069829 no 2489 0.222839801450754 843 3989527
SGTC_936 3005-4620 401 µM -0.76282897311524 0.270595124356305 no 2490 0.222782699834598 860 777207
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.764560057040834 0.270169194235957 no 2491 0.222266780824258 858 140250 A respiratory chain inhibitor.
SGTC_1470 k295-0292 231 µM -0.764781697387882 0.270114684247564 no 2492 0.222200774094653 866 5045612
SGTC_2297 7971671 152.32 µM -0.768374873508041 0.269231750677797 no 2493 0.221132251827056 856 909016
SGTC_24 0417-1663 219 µM -0.768507364117511 0.269199222104015 no 2494 0.221092908658171 882 4329390
SGTC_2163 5671233 125 µM -0.770211169139127 0.268781086367842 no 2495 0.220587319775719 847 701023
SGTC_2954 9074818 52.69 µM -0.771563999131524 0.268449316937592 no 2496 0.220186351797174 866 16648742
SGTC_1311 1190-0148 100 µM -0.771888937749034 0.268369659333329 no 2497 0.220090104885201 874 1961333
SGTC_1854 st056233 32.9 µM -0.772984412034965 0.268101195138102 no 2498 0.219765802968172 872 5393174
SGTC_947 3447-0010 211 µM -0.773887076202844 0.267880083897118 no 2499 0.219498786427878 873 748350
SGTC_2334 9017922 200 µM -0.774940322044507 0.26762220322839 no 2500 0.219187462134666 860 3163164
SGTC_2735 sertaconazole 140 nM -0.777011804355736 0.26711537906964 no 2501 0.218575902976779 898 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_662 k832-1615 104 µM -0.778824228892705 0.266672335706734 no 2502 0.218041631579988 853 5878478
SGTC_2004 4023728 41.89 µM -0.779279838387568 0.266561021383247 no 2503 0.21790744429148 879 360084 YDR527W RBA50
SGTC_2033 5192550 145 µM -0.779554246522566 0.266493989440888 no 2504 0.217826647880625 835 182073
SGTC_2888 9058547 12.99 µM -0.779707117141844 0.26645665016997 no 2505 0.217781644329326 854 16476514
SGTC_1680 diphenhydramine 100 µM -0.781280985262968 0.266072380423736 no 2506 0.217318625563537 842 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1550 gossypolone 36.6 µM -0.782667369766047 0.265734118633743 no 2507 0.216911234247068 868 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1418 3966-3099 2.4 µM -0.785565910119501 0.265027613385487 no 2508 0.216060921310571 850 740335
SGTC_2881 9058953 51.95 µM -0.787594453764589 0.264533733910378 no 2509 0.215466979941951 835 17122249
SGTC_15 0266-0086 27.098 µM -0.788701985072971 0.264264286510988 no 2510 0.21514310372042 893 1712902 YIL048W NEO1
SGTC_748 act1.228 77.9 µM -0.788866301023184 0.264224322569525 no 2511 0.215095076768371 855 4421505 YNR035C ARC35
SGTC_1923 st058458 19.1 µM -0.789365566801887 0.264102913023054 no 2512 0.214949187476253 888 3534982
SGTC_1995 st072814 61.1 µM -0.790507537121731 0.263825319929526 no 2513 0.214615711119499 873 5769371
SGTC_1846 st056244 14.8 µM -0.792449206930576 0.263353675577385 no 2514 0.214049398640173 879 5393182
SGTC_3225 9130819 49.47 µM -0.792794176174612 0.263269925343494 no 2515 0.213948875077214 878 4547121
SGTC_2233 sulbentine 40.3845 µM -0.79299663523403 0.263220779489232 no 2516 0.213889891586027 855 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1552 6-methylflavone 10.6 µM -0.793280215288839 0.263151949826836 no 2517 0.213807290597481 863 689013
SGTC_2827 7993847 71.43 µM -0.793503293872049 0.263097811354759 no 2518 0.213742325489312 834 2985692
SGTC_2658 polymyxin b sulfate 77.05 µM -0.794312441819464 0.262901488713963 no 2519 0.213506781336181 877 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3294 9122953 26.2835 µM -0.794579120258056 0.262836801244307 no 2520 0.213429184007767 874 16459826
SGTC_1977 st070720 65.3 µM -0.796003028790449 0.262491545401027 no 2521 0.213015137482999 865 682188
SGTC_2197 6588183 93.1375 µM -0.799526703230491 0.261638157474581 no 2522 0.211992534615131 852 884136
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.801215595931493 0.261229635086282 no 2523 0.211503421969452 871 2346 DNA damaging agent; causes G2/M arrest.
SGTC_623 k072-0108 16.9 µM -0.802888377807817 0.26082533302943 no 2524 0.211019627075485 874 5382803
SGTC_881 0833-0569 170 µM -0.806691897917855 0.259907242976727 no 2525 0.20992200657638 872 5418700
SGTC_923 1900-2434 73.3 µM -0.807004813086739 0.25983178609128 no 2526 0.209831855088062 885 5910570
SGTC_2693 st077581 40.7 µM -0.807054690360379 0.259819759646825 no 2527 0.209817487448608 861 25238761
SGTC_1410 3909-8106 77.9 µM -0.807439369896264 0.259727015088114 no 2528 0.209706696154945 874 1039210
SGTC_3211 9128781 49.47 µM -0.80773570100352 0.259655582602408 no 2529 0.20962137349352 879 17194361
SGTC_906 1165-0455 526 µM -0.809613075671767 0.259203265339361 no 2530 0.209081295312031 875 3252859
SGTC_2335 9018011 154.17 µM -0.812508652892312 0.258506431137057 no 2531 0.208249911762681 865 6458208
SGTC_664 1222-0054 14.9 µM -0.813048909680436 0.258376523302701 no 2532 0.208095008416545 868 6813991
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.814475367019574 0.258033686107359 no 2533 0.207686339107569 841 279621
SGTC_2203 7227154 166.4 µM -0.814479158193218 0.258032775244671 no 2534 0.207685253596941 871 896304
SGTC_2242 6630449 61.2675 µM -0.815878605969995 0.257696659612537 no 2535 0.207284784690296 883 691249 YDR170C SEC7
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.816000772516067 0.257667328768572 no 2536 0.20724984693969 883 5106787 A p450 inhibitor.
SGTC_1721 st082152 9.2685 µM -0.816215967642824 0.257615667001628 no 2537 0.207188312918426 891 5296051
SGTC_2402 5553605 200 µM -0.816298141503915 0.257595940990536 no 2538 0.207164818545629 894 6758546
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.816363384318045 0.257580279872108 no 2539 0.207146166059879 871 688761
SGTC_1932 st074806 40.9 µM -0.818595836805955 0.257044692083351 no 2540 0.206508521525724 880 17251235
SGTC_1759 st043059 70 µM -0.819022463335746 0.256942406055732 no 2541 0.206386798735849 894 669426
SGTC_1743 st037606 46.3785 µM -0.822498239229909 0.256109859669368 no 2542 0.205396694192031 861 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1738 st035555 74 µM -0.822890100604095 0.256016086142233 no 2543 0.205285246343412 885 5331140
SGTC_23 0213-0011 39.996 µM -0.828080323880309 0.254775742929165 no 2544 0.20381250590639 893 627608
SGTC_1996 st072960 66.8 µM -0.828340088733448 0.254713747914518 no 2545 0.203738962764113 866 1719405
SGTC_3280 9140961 49.47 µM -0.828843171797442 0.254593705477899 no 2546 0.203596577756154 904 4901226
SGTC_772 k072-0172 35.3 µM -0.829950366610123 0.254329618204352 no 2547 0.203283423202521 853 5861980
SGTC_1076 itraconazole 331 nM -0.830809628514985 0.254124766708493 no 2548 0.203040591224028 873 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_712 r015-0009 80.6 µM -0.831278938963813 0.254012917762118 no 2549 0.202908034766338 896 6813872 YLR060W FRS1
SGTC_1202 1988-0068 29.6 µM -0.833721359044183 0.253431242468427 no 2550 0.202219009594364 872 2850480
SGTC_2409 alverine citrate 63.97 µM -0.834019649328211 0.253360251053027 no 2551 0.202134955667727 866 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2238 6671620 73.2395 µM -0.835413930867001 0.253028558535216 no 2552 0.201742344425001 865 729941
SGTC_1292 0kpi-0043 232 µM -0.836295730599011 0.252818900844231 no 2553 0.201494277200241 876 3333905
SGTC_995 3931-2021 34.6 µM -0.836479231517855 0.252775282959353 no 2554 0.201442677847329 898 730143
SGTC_2338 7999974 200 µM -0.836627119047221 0.252740133205658 no 2555 0.201401098528208 887 315925
SGTC_2044 5102272 200 µM -0.837270133179734 0.252587332206077 no 2556 0.201220371698468 886 592666
SGTC_1972 st070201 17.4 µM -0.839846394741547 0.251975617376303 no 2557 0.200497258322049 885 2829099
SGTC_2019 4016004 108 µM -0.840317453945744 0.251863852346754 no 2558 0.200365208877902 894 45595336
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.842521573666855 0.251341243658523 no 2559 0.1997480345672 893 6708561
SGTC_2763 lisinopril 49.32 µM -0.842844562176523 0.25126470952472 no 2560 0.199657690907666 878 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1805 st050013 60.3 µM -0.843531836702316 0.251101896572959 no 2561 0.19946553403097 873 4037144
SGTC_179 1273-0063 6.77 µM -0.843705621437195 0.251060736413793 no 2562 0.199416962743484 900 3108139
SGTC_2245 6637752 200 µM -0.846863288635851 0.250313478750429 no 2563 0.198535663484833 899 681890
SGTC_1691 st019933 84.6 µM -0.847216764966563 0.250229902504609 no 2564 0.198437155305076 914 6176082
SGTC_1277 0873-0036 22 µM -0.849164819339599 0.24976956848931 no 2565 0.197894793124275 891 5965735
SGTC_269 exalamide 29 µM -0.849354266392755 0.249724825300974 no 2566 0.197842096565058 892 3316 A derivative of salicylamide.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.849563067310327 0.249675516090783 no 2567 0.197784026360416 890 688798
SGTC_1127 asiatic acid 681.4 nM -0.849671077843236 0.249650010981058 no 2568 0.197753991292457 902 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2318 6029776 164 µM -0.850725695511064 0.249401051162477 no 2569 0.197460872962012 884 818325
SGTC_1424 4048-1941 275 µM -0.852231356951648 0.249045843867838 no 2570 0.197042847988267 885 X1424
SGTC_2499 avocadenofuran 51.48 µM -0.854714787124029 0.248460555406426 no 2571 0.196354531136557 902 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_144 4161-2749 112.381 µM -0.857732592452497 0.24775031453712 no 2572 0.195520069311804 879 797501 YMR168C CEP3
SGTC_833 3852-0053 558 µM -0.858177034469922 0.247645806711398 no 2573 0.195397357595371 925 3123681
SGTC_2706 st078239 82.5 µM -0.858943399424463 0.247465655992328 no 2574 0.195185871947898 899 15434492
SGTC_2012 4023501 200 µM -0.860191107982737 0.24717250489548 no 2575 0.19484185273314 900 3477460
SGTC_348 k064-0012 10.7 µM -0.861625110012504 0.246835813374258 no 2576 0.194446924328196 892 5066323
SGTC_608 k048-0125 159 µM -0.862852035121008 0.246547936760968 no 2577 0.194109412627218 890 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1553 gossypol 38.6 µM -0.864590412265005 0.24614036498733 no 2578 0.193631818369014 865 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2650 prasterone 100 µM -0.869118457566644 0.245080439327358 no 2579 0.192391171025756 876 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2781 5567276 71.43 µM -0.870318832230651 0.244799867642515 no 2580 0.192063095055375 910 2853274
SGTC_1809 st050081 57.6 µM -0.870348979291088 0.244792823392648 no 2581 0.192054859932097 883 5036894
SGTC_533 1222-0222 6.71 µM -0.870529347412975 0.244750680331827 no 2582 0.192005594178721 916 3982874
SGTC_1241 0364-0022 50.8 µM -0.873530105327098 0.244050125817044 no 2583 0.191187102173749 913 4563895
SGTC_1731 st035964 63 µM -0.873956882358861 0.24395057872162 no 2584 0.191070867718008 930 6739575
SGTC_2115 tiliquinol 12.7705 µM -0.874815140857485 0.243750453551513 no 2585 0.190837248773558 894 71208 A bioactive hydroxyquinoline.
SGTC_785 1270-0111 65.3 µM -0.874837612007674 0.243745215012398 no 2586 0.190831134456102 894 6741994
SGTC_1909 st060837 51.5 µM -0.87657326866399 0.243340777442684 no 2587 0.190359231895225 878 678937
SGTC_152 4469-0003 551.229 µM -0.877188832753741 0.243197427689097 no 2588 0.190192040315125 876 697280
SGTC_1422 4031-0024 15.5 µM -0.878397194221509 0.242916162811514 no 2589 0.189864103245988 918 782427
SGTC_700 3453-2283 142 µM -0.880291015760759 0.242475700765225 no 2590 0.189350839185535 893 565664
SGTC_817 1391-0715 46 µM -0.880975427824038 0.242316627767928 no 2591 0.189165559926599 900 1353946
SGTC_2029 5175081 200 µM -0.881150280799899 0.242275997013718 no 2592 0.189118242858756 893 1380876
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.881569509096034 0.2421785955722 no 2593 0.189004824931894 902 641818 YHR062C RPP1
SGTC_2444 5485484 36.41 µM -0.881595067434092 0.242172658160187 no 2594 0.188997911740329 931 6790631
SGTC_2372 9071633 200 µM -0.881972882400732 0.242084897844062 no 2595 0.188895735972344 910 21321366
SGTC_472 calcifediol 10 µM -0.88427993843808 0.241549380336592 no 2596 0.188272557570177 907 5283731 A vitamin D metabolite.
SGTC_2237 6667747 47.222 µM -0.884381103052155 0.24152591257742 no 2597 0.188245260202808 921 729940 YDL015C TSC13
SGTC_2000 st075254 36.4 µM -0.884793263213628 0.241430314125181 no 2598 0.188134071782973 867 17234175
SGTC_1974 st069448 26.9 µM -0.885472389424051 0.241272839102505 no 2599 0.187950952384691 872 6323587 YNR016C ACC1
SGTC_2581 avocatin a 64 µM -0.885575134719882 0.241249019500874 no 2600 0.187923257759172 915 6710728 A skin care supplement.
SGTC_2685 mycophenolic acid 18.85 µM -0.885657702563692 0.241229878595525 no 2601 0.187901003719491 874 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2368 9071271 200 µM -0.887037071247861 0.240910234985937 no 2602 0.187529471048811 906 27209959
SGTC_1458 k015-0034 6.33 µM -0.887671974237931 0.240763185228357 no 2603 0.187358612732344 908 3598957
SGTC_2011 4012611 177 µM -0.889854566137099 0.240258048313942 no 2604 0.186771991269752 915 2049887
SGTC_578 3460-0051 92 µM -0.892634202547821 0.239615568956096 no 2605 0.186026548372354 923 2876744
SGTC_638 3970-0837 4.09 µM -0.892816551328095 0.239573454042621 no 2606 0.185977710631335 878 4118451 YLR208W SEC13
SGTC_3209 9113616 49.47 µM -0.894787015282223 0.239118617442645 no 2607 0.185450476393399 900 16649353
SGTC_2108 5365811 200 µM -0.899220838178074 0.238096898710799 no 2608 0.184267521503204 888 780283
SGTC_1209 2323-2347 50.3 µM -0.899403022532025 0.238054967852879 no 2609 0.184219014916323 872 5412760
SGTC_612 0302-0167 22.4 µM -0.899645964168045 0.237999059627633 no 2610 0.184154344067374 915 235821
SGTC_3202 9113761 49.47 µM -0.900881153574615 0.237714916510302 no 2611 0.183825756352061 908 4798415
SGTC_2403 6032726 181.2 µM -0.901876871067975 0.23748599708426 no 2612 0.183561139490792 915 2881040
SGTC_3258 9138477 49.47 µM -0.902353455676108 0.237376471215719 no 2613 0.18343456881551 915 4970355
SGTC_1876 myriocin 605 nM -0.90346487888291 0.237121158270069 no 2614 0.183139610035904 905 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2050 5263056 171 µM -0.904288266586249 0.236932109348695 no 2615 0.182921283413923 883 763468 YGL055W OLE1
SGTC_2319 6033012 152.6 µM -0.904294117679176 0.236930766240666 no 2616 0.182919732539904 918 847246
SGTC_1687 st020778 55.3625 µM -0.904661243574558 0.236846501511533 no 2617 0.182822439606777 897 4259299
SGTC_1366 1683-0113 21.9 µM -0.905144459401943 0.236735616313013 no 2618 0.182694430644258 914 708623
SGTC_1031 k035-0009 16 µM -0.905517441151389 0.236650046436383 no 2619 0.182595662128225 916 5180959
SGTC_1415 3966-0071 78.1 µM -0.906150219474904 0.236504912677023 no 2620 0.18242817371724 895 2893185
SGTC_467 ro 31-8220 72.8 µM -0.906387947359334 0.236450400174366 no 2621 0.182365274965559 903 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2295 7971645 200 µM -0.910730177495706 0.2354559171958 no 2622 0.181218779787897 937 2978226 YKL099C UTP11
SGTC_1263 0774-1208 64.8 µM -0.913592068672719 0.234801734154752 no 2623 0.180465617754662 911 906585
SGTC_1165 k072-0275 30.3 µM -0.913951485756173 0.234719648168327 no 2624 0.180371169176311 903 6153523 YGL055W OLE1
SGTC_362 0310-0100 9.03 µM -0.914346875022105 0.234629364954343 no 2625 0.180267303564779 906 790235
SGTC_317 4495-0002 170 µM -0.914454388990767 0.234604818528361 no 2626 0.180239066993574 898 15991618
SGTC_5 0352-0601 109.883 µM -0.914775603770362 0.234531490706565 no 2627 0.180154722361775 894 762456
SGTC_3342 9147791 14.508 µM -0.916709431814984 0.234090298980866 no 2628 0.179647461179948 893 1838168
SGTC_1982 st072467 71.9 µM -0.916994244051421 0.234025359564228 no 2629 0.179572828165403 921 3163533
SGTC_1603 st002045 67.8 µM -0.918057092805914 0.233783109858357 no 2630 0.179294488309664 921 5887985
SGTC_276 colchicine 750 µM -0.918614292323154 0.233656165760171 no 2631 0.179148676820379 896 2833 A microtubule depolymerizer.
SGTC_1179 1021-1431 9.29 µM -0.922176846034217 0.232845430164915 no 2632 0.178218169181649 933 2840958
SGTC_844 0330-0132 15.3 µM -0.92268583636252 0.232729726220209 no 2633 0.178085474522818 904 2828079
SGTC_1808 st050063 61.5 µM -0.92527279351845 0.232142151955831 no 2634 0.177412013474443 910 4011993
SGTC_779 1360-0071 233 µM -0.926978955373662 0.231755084573491 no 2635 0.176968730435762 877 7566
SGTC_2529 gangaleoidin 93.61 µM -0.928626369913926 0.231381686327683 no 2636 0.176541375476893 911 4565183
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.929159635650129 0.231260889765154 no 2637 0.17640318123758 879 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.929405155622112 0.231205285854376 no 2638 0.176339578476842 958 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_236 1509-0011 5.31 µM -0.932972728295619 0.230398165274242 no 2639 0.175417024677168 912 3107280
SGTC_2147 5545932 89.7195 µM -0.934009991852187 0.230163792743718 no 2640 0.175149369438304 932 797404
SGTC_2269 7935389 174.42 µM -0.934330407680575 0.230091420885251 no 2641 0.175066741810544 899 97605
SGTC_848 0368-0089 85.6 µM -0.934744945503565 0.229997808723318 no 2642 0.174959879055127 904 762535
SGTC_1338 1486-1223 76 µM -0.934896521460905 0.229963584713094 no 2643 0.174920814972861 915 3444526
SGTC_2800 7887935 81.82 µM -0.934929637731977 0.229956107840705 no 2644 0.17491228100031 937 2961002
SGTC_3200 9114385 49.47 µM -0.936042864444057 0.229704846701711 no 2645 0.174625559253406 897 17018030 YLR208W SEC13
SGTC_1212 0520-0165 585 µM -0.937718372298819 0.229326965775531 no 2646 0.174194579806863 948 5403258
SGTC_74 000s-0487 160.283 µM -0.941089763955483 0.228567665624064 no 2647 0.173329430326098 907 677548
SGTC_838 0109-0203 71.4 µM -0.945197676537855 0.227644398744986 no 2648 0.172278982722387 897 759422
SGTC_3329 9141233 27.5565 µM -0.945547396403402 0.227565895153713 no 2649 0.172189742728617 908 4909101 YNL103W MET4
SGTC_1071 trifluoperazine 6.31 µM -0.94717480652275 0.22720078181575 no 2650 0.171774855421415 940 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1445 4239-0156 97.7 µM -0.94780835149768 0.227058733825497 no 2651 0.171613514070826 944 4008346
SGTC_3297 9117502 71.43 µM -0.947996680510084 0.227016517975251 no 2652 0.171565572050259 906 7453720
SGTC_1985 st071382 65.5 µM -0.950881012074846 0.22637051914395 no 2653 0.170832390882984 950 6123237
SGTC_1304 1165-0502 251 µM -0.950930061376776 0.226359542640654 no 2654 0.170819940184169 905 767425
SGTC_2388 9080168 200 µM -0.952621471586667 0.225981214191154 no 2655 0.170390947097234 916 15943073
SGTC_2158 5657123 3.6195 µM -0.953499411704963 0.225784980774878 no 2656 0.170168547055495 949 2858827
SGTC_661 1304-0007 33.6 µM -0.953532987036308 0.225777478074534 no 2657 0.170160045437424 916 3117130
SGTC_2630 antimycin a 100 µM -0.953673031216574 0.225746185503015 no 2658 0.170124587750662 935 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_423 5-fluorouracil 457 µM -0.953740730103334 0.225731059211769 no 2659 0.170107448815322 904 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1949 st076024 69.1 µM -0.954598582519911 0.22553943474929 no 2660 0.169890367138507 920 2921930
SGTC_552 k242-0005 476 µM -0.956796513120874 0.225048888062671 no 2661 0.16933498628072 932 4088318
SGTC_39 0986-0283 58.349 µM -0.957147523235276 0.224970603647838 no 2662 0.16924639984204 877 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2362 9071156 126 µM -0.957162163770293 0.224967338761831 no 2663 0.169242705572588 934 653133
SGTC_2795 7780010 54.55 µM -0.959795842703358 0.224380457049272 no 2664 0.168578987529725 922 953673
SGTC_1891 st059073 26.2 µM -0.960159678429629 0.224299449278106 no 2665 0.168487428373428 914 688754
SGTC_515 4092-1064 102 µM -0.96114790466363 0.224079505208883 no 2666 0.168238902921294 951 717353
SGTC_1832 st054113 55 µM -0.961612286347275 0.223976192660502 no 2667 0.168122198732745 913 1251267
SGTC_1604 st002052 72.4 µM -0.961622972021895 0.223973815701262 no 2668 0.168119513919265 914 6254834 YHR062C RPP1
SGTC_563 tetrahydrosecaminediol 614 µM -0.962777218904412 0.223717145347096 no 2669 0.167829667755825 925 334274 A psychoactive constituent of the cannabis plant.
SGTC_7 0192-1582 4.227 µM -0.962922975758985 0.223684745231644 no 2670 0.167793089236459 948 252616
SGTC_1370 2001-0092 44.6 µM -0.964047898455111 0.223434777293984 no 2671 0.167510956130371 905 790957
SGTC_3025 9087895 49.47 µM -0.964352768768676 0.223367059751095 no 2672 0.167434546647516 926 17173641
SGTC_1383 3049-0032 20.7 µM -0.965730142099198 0.223061264329374 no 2673 0.167089616289184 931 712864
SGTC_172 1112-0046 2.638 µM -0.9658126072788 0.223042963516355 no 2674 0.167068979395459 953 2802135 YIL048W NEO1
SGTC_976 1348-1067 47.6 µM -0.965857666856688 0.223032964179396 no 2675 0.167057703940023 922 5310671 YGL099W LSG1
SGTC_214 4373-3496 70 µM -0.966100628062985 0.222979052162547 no 2676 0.166996915150101 931 3779166
SGTC_2840 9008771 71.43 µM -0.967557167133754 0.222656008256877 no 2677 0.166632788843516 884 2992978
SGTC_1056 3448-1962 115 µM -0.967688329997193 0.222626930915419 no 2678 0.166600024056951 923 715507
SGTC_2611 pyromycin 23.93 µM -0.967788380887905 0.222604752206205 no 2679 0.166575033908927 912 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2415 st077333 57.7 µM -0.970645321238329 0.221971973754293 no 2680 0.165862464504155 893 2766255
SGTC_38 0929-0051 58.268 µM -0.971056259347371 0.221881040395152 no 2681 0.165760131887578 924 1379719
SGTC_1176 0848-0131 83.3 µM -0.976348051909909 0.220711962519351 no 2682 0.164446007591219 936 6769040
SGTC_729 4092-0585 94.1 µM -0.976892368208288 0.220591911051288 no 2683 0.164311220226896 909 2169061
SGTC_3261 9137475 49.47 µM -0.97891008557727 0.220147220698703 no 2684 0.163812204211264 869 17027690
SGTC_1281 0884-0031 11.8 µM -0.983650181131917 0.219104562990607 no 2685 0.162643771396061 927 1548255
SGTC_2728 chlorpromazine 9.18 µM -0.988426212400998 0.218056878302236 no 2686 0.161471977638496 957 2726 A thorazine and dopamine antagonist.
SGTC_2929 9013348 24.6 µM -0.989851189814977 0.217744851189565 no 2687 0.161123429963053 929 2995952
SGTC_2738 aclarubicin 5.55 µM -0.990554999947103 0.21759083305656 no 2688 0.160951460141912 918 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2863 9028737 58.44 µM -0.99081120243489 0.217534782655044 no 2689 0.160888889069892 918 6460917
SGTC_932 2857-0803 154 µM -0.991725857439271 0.217334748064731 no 2690 0.160665636938515 928 674898
SGTC_1661 st013063 9.66 µM -0.992635439157245 0.217135928378165 no 2691 0.160443823848563 946 721395
SGTC_1769 st044406 64.4 µM -0.99338398163355 0.216972388085724 no 2692 0.160261432385197 939 670903
SGTC_1132 3456-3614 2.5 µM -0.993429402600268 0.216962466881319 no 2693 0.160250369377982 947 3125502
SGTC_1988 st071872 53.4 µM -0.993627732680728 0.216919149139122 no 2694 0.16020206874455 923 16414116
SGTC_19 0279-0214 38.434 µM -0.994073350403158 0.216821838955194 no 2695 0.160093579235544 929 3566274 YBR002C RER2
SGTC_1145 3546-0597 10.2 µM -0.995007098957872 0.216618016811459 no 2696 0.159866405852983 923 875334
SGTC_683 panaxydol 45 µM -0.995142264462354 0.21658852156305 no 2697 0.15983353867131 906 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3302 9125395 16.351 µM -0.995435211004924 0.216524603974515 no 2698 0.159762320231225 906 17599668
SGTC_3295 9122362 53.5725 µM -0.998918084665761 0.215765517378039 no 2699 0.158917187387025 977 4730473
SGTC_1663 st014140 55.4 µM -1.00047987110204 0.215425630150428 no 2700 0.158539167033278 927 4207120
SGTC_2514 salinomycin 42.74 µM -1.00072143852453 0.215373086256017 no 2701 0.158480749898654 942 23682228 A polyether potassium ionophore.
SGTC_2408 sulbentine 18.36 µM -1.00229823135047 0.215030297080891 no 2702 0.158099788254542 908 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1261 0712-0010 12.7 µM -1.00335223591289 0.214801336989132 no 2703 0.15784547054758 938 2840123
SGTC_581 0958-0271 211 µM -1.00440991510597 0.214571721105539 no 2704 0.157590536415414 928 4591145
SGTC_524 r073-0010 27.8 µM -1.00458738668051 0.214533207062467 no 2705 0.157547786673869 934 2772106
SGTC_1967 st070177 51.4 µM -1.00614332489994 0.214195716810146 no 2706 0.157173315166682 955 5729214
SGTC_278 4092-0821 23.9 µM -1.01016141783183 0.213325603935496 no 2707 0.156208980354489 935 877900
SGTC_543 3844-1095 191 µM -1.01213711294267 0.212898526544249 no 2708 0.155736249777155 941 4230703
SGTC_2697 mebhydrolin 72.4 µM -1.01978324474889 0.211250404979189 no 2709 0.153915635650534 936 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2766 oltipraz 83.91 µM -1.0205951661773 0.211075835649271 no 2710 0.153723140293743 891 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3119 9125183 49.47 µM -1.0208880023418 0.211012894382766 no 2711 0.153653752007779 898 22695334
SGTC_991 3996-0057 64.7 µM -1.02105953365807 0.210976031101958 no 2712 0.15361311685185 920 715343
SGTC_2152 5568786 200 µM -1.02116934073638 0.210952434774212 no 2713 0.1535871076833 933 5399883
SGTC_2438 5259590 200 µM -1.02380287362901 0.210386981358883 no 2714 0.15296419641063 942 1201127
SGTC_2110 5483698 200 µM -1.02619890277549 0.209873296957115 no 2715 0.152398919232113 916 2848765 YHR062C RPP1
SGTC_2288 7946289 167.31 µM -1.0263591499177 0.209838967912655 no 2716 0.152361162854333 950 1246052
SGTC_2102 5377816 72.7585 µM -1.03148576252428 0.208742459092456 no 2717 0.151156540702205 933 1379702
SGTC_1559 coumarin 343 70.1 µM -1.03271830709421 0.208479339896632 no 2718 0.150867871837801 935 108770 A hepatotoxic, DNA x-linker.
SGTC_3337 9144342 33.5465 µM -1.03343489248525 0.208326455765102 no 2719 0.150700212317866 921 17682949
SGTC_2191 5911152 200 µM -1.03621646890187 0.207733630904468 no 2720 0.150050582625017 926 2875902
SGTC_665 3914-0008 307 µM -1.03652690328701 0.207667531291437 no 2721 0.149978197495111 946 1069549
SGTC_3269 9137823 49.47 µM -1.03656300519181 0.2076598450568 no 2722 0.149969780992507 890 17682936
SGTC_3153 9100258 49.47 µM -1.0370019632994 0.207566402631054 no 2723 0.149867471087726 945 25236848
SGTC_1405 3909-7894 12 µM -1.04188728644667 0.206528126331073 no 2724 0.148731969572546 910 7104060
SGTC_120 rhodamine 6G 52.259 µM -1.04411700405837 0.206055269427896 no 2725 0.148215629825975 957 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2793 7325131 81.82 µM -1.04464807689405 0.205942739387045 no 2726 0.148092825382306 930 4176441
SGTC_988 1497-1057 103 µM -1.04580282760353 0.205698182884557 no 2727 0.147826037708559 941 3533044
SGTC_1710 st031758 61.5 µM -1.0470261861824 0.205439284520005 no 2728 0.147543750477775 938 5394341
SGTC_3075 9116269 49.47 µM -1.04796862393232 0.20523996922067 no 2729 0.147326531505645 929 17015205 YNL244C SUI1
SGTC_3174 9107204 49.47 µM -1.05192111363326 0.204405312920947 no 2730 0.146417872054236 956 3938802
SGTC_908 3448-7491 47.7 µM -1.05346086545785 0.20408070765463 no 2731 0.14606491060313 887 1203031
SGTC_1303 1160-0052 261 µM -1.05452270142513 0.203857033998812 no 2732 0.145821836374168 910 3562476
SGTC_59 0330-0160 1.33 µM -1.05624428229663 0.203494697018693 no 2733 0.14542831216744 947 4293482
SGTC_1785 bathophenanthroline 24 µM -1.057188111454 0.203296214709459 no 2734 0.14521287224615 899 72812 An iron chelator.
SGTC_265 mycophenolic acid 32.932 µM -1.05732325096524 0.203267805039013 no 2735 0.145182042674724 955 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1825 st052143 62.6 µM -1.06021553436845 0.202660343661309 no 2736 0.144523277740861 957 674173
SGTC_1475 4092-1048 11.7 µM -1.06163297436069 0.202363037704751 no 2737 0.144201169048743 963 2881759
SGTC_2692 st077426 47.7 µM -1.06191861390605 0.202303156822709 no 2738 0.144136317017416 958 25238571
SGTC_1824 st053723 68.6 µM -1.06283941291172 0.202110194590975 no 2739 0.143927391321916 948 675225
SGTC_845 0330-0138 4.51 µM -1.06372418757176 0.201924885399187 no 2740 0.143726831940641 934 9039800
SGTC_2848 9016370 25.97 µM -1.06404157389459 0.201858436089646 no 2741 0.14365493326887 903 7894410
SGTC_3208 9114115 49.47 µM -1.06433491426163 0.201797032784118 no 2742 0.143588503402178 954 650895
SGTC_1125 tnp00248 1.32998 µM -1.06465946226887 0.201729109991472 no 2743 0.143515030416062 940 24207736
SGTC_2200 6600604 21.907 µM -1.0651351930831 0.201629571763929 no 2744 0.14340737769647 973 2904777
SGTC_1070 indatraline 8.81 µM -1.0655022848113 0.201552784450677 no 2745 0.143324346099877 940 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1686 st019653 115.5 µM -1.06565871944658 0.201520067176652 no 2746 0.143288972392296 966 97252
SGTC_3293 9120939 62.045 µM -1.06689194786871 0.201262257013968 no 2747 0.143010315659729 948 934087
SGTC_548 1436-0017 110 µM -1.06720915169048 0.201195976573233 no 2748 0.142938700443568 949 9677137
SGTC_1971 st069429 63.5 µM -1.06888709842467 0.200845583680364 no 2749 0.142560273050087 930 1246522 YGL099W LSG1
SGTC_1273 0849-0096 14.1 µM -1.07125085222229 0.200352600654863 no 2750 0.142028326017716 966 5286025
SGTC_328 k915-0120 63.5 µM -1.07190717508183 0.200215847419226 no 2751 0.141880863576136 941 6624543
SGTC_1390 3413-2614 145 µM -1.07245884495171 0.200100943370275 no 2752 0.141756994760054 963 3421432
SGTC_1689 st020265 53.493 µM -1.07421247419419 0.199735953679672 no 2753 0.141363731390279 956 5758320 YPR016C TIF6
SGTC_3010 9080089 71.4286 µM -1.07473917380718 0.19962640789649 no 2754 0.141245759932484 940 17027233
SGTC_1022 4477-0945 21.3 µM -1.07848068973813 0.198849268654405 no 2755 0.140409647389842 935 4648966
SGTC_1089 terbinafine 2.25 µM -1.08027601730209 0.198477014843669 no 2756 0.140009643030622 933 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1447 4239-0816 81.9 µM -1.08160949571192 0.198200795856702 no 2757 0.139713041671884 938 1341554
SGTC_3205 9113483 49.47 µM -1.08212541332665 0.198093990093696 no 2758 0.139598402453502 946 17018033
SGTC_1760 st045453 10.4495 µM -1.08297291663855 0.197918614591713 no 2759 0.139410222280347 960 3323419 YIL048W NEO1
SGTC_1702 st027038 51 µM -1.08406567704269 0.197692626040502 no 2760 0.139167839867598 953 5521182
SGTC_43 0570-0105 72.5 µM -1.08432673566531 0.197638660842578 no 2761 0.139109977584938 938 1114046 YDL195W SEC31
SGTC_1618 st003135 44.5 µM -1.08684041104643 0.197119497717362 no 2762 0.138553672463786 954 1270615
SGTC_2946 9065502 71.43 µM -1.08880606769421 0.196714095454994 no 2763 0.13811970765866 893 16489101
SGTC_1368 1852-0141 284 µM -1.0891629686241 0.196640541462758 no 2764 0.138041012938628 964 2838987
SGTC_1220 1838-0075 193 µM -1.09020192691906 0.196426516595137 no 2765 0.137812102367675 923 5529645
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.09138620659382 0.196182727856197 no 2766 0.137551489607213 950 5355888
SGTC_1898 st060199 18.6 µM -1.09267982791485 0.195916640471156 no 2767 0.13726719978604 930 688866
SGTC_978 1416-0512 87.4 µM -1.09604458568246 0.195225563384503 no 2768 0.136529631633752 969 6814003
SGTC_1322 1348-1070 12 µM -1.09639070534737 0.195154559072141 no 2769 0.136453914878597 932 6758089
SGTC_2830 7992007 71.43 µM -1.09759142261422 0.194908361031046 no 2770 0.136191469976986 948 1952075
SGTC_910 3454-3003 490 µM -1.10284684876117 0.193832999689358 no 2771 0.135046839645352 963 820824
SGTC_1758 st042942 75.2445 µM -1.10326880746442 0.19374681594071 no 2772 0.134955224130635 935 669317
SGTC_225 nsc-122657 1.016 µM -1.1035130196177 0.193696947045245 no 2773 0.134902220360722 962 275685
SGTC_813 k007-0158 173 µM -1.10431961943467 0.193532292428244 no 2774 0.134727257538311 955 6523916
SGTC_2239 6685329 187.64 µM -1.10651581399267 0.193084406853983 no 2775 0.134251661543979 930 805680
SGTC_1382 3002-2117 298 µM -1.10858806716318 0.192662378332832 no 2776 0.133803964107494 994 1497314
SGTC_2576 guaiol 23.12 µM -1.10914701481359 0.192548641426769 no 2777 0.13368338287213 922 227829
SGTC_53 0973-0023 39.979 µM -1.1095796694363 0.19246063131802 no 2778 0.133590098020959 947 674768
SGTC_2305 7443522 69.23 µM -1.11340277368517 0.191684009119563 no 2779 0.132767742141659 930 5415886
SGTC_1189 1431-2119 7.28 µM -1.11414390463449 0.191533678790096 no 2780 0.132608727978266 956 3107275
SGTC_440 fluspirilene 35.1 µM -1.11441546194829 0.191478614436643 no 2781 0.132550496557843 975 3396 An atypical antipsychotic.
SGTC_2196 6573537 42.6665 µM -1.11482458709092 0.191395673428078 no 2782 0.132462799035243 970 2903087
SGTC_2568 diosmetin 100 µM -1.11503146099177 0.191353742735323 no 2783 0.13241847005473 964 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_774 k060-0086 136 µM -1.11526723566599 0.191305961090714 no 2784 0.132367960677259 970 5911235
SGTC_2062 5245942 200 µM -1.11655149323747 0.191045824331589 no 2785 0.132093070766285 980 1376160
SGTC_911 3456-4043 236 µM -1.12091412284295 0.190163759744497 no 2786 0.131162209366802 951 914281
SGTC_2601 securinine 100 µM -1.12301632979121 0.189739616874162 no 2787 0.130715279569378 955 442872 A GABA receptor antagonist.
SGTC_474 dl-dihydrosphingosine 5 µM -1.12412656689855 0.189515849555692 no 2788 0.13047966814004 932 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1616 st002734 56.1 µM -1.12479166269171 0.189381877887384 no 2789 0.130338664119931 951 4026101
SGTC_2670 beta-carotene 100 µM -1.12509399645845 0.18932099742619 no 2790 0.130274602535471 910 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_425 3825-7017 13.1 µM -1.12643971351926 0.189050158744926 no 2791 0.129989722472001 949 3397440
SGTC_1574 spiramycin 23.7 µM -1.1273876455876 0.188859521507712 no 2792 0.129789310101144 958 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1853 st056710 91.2 µM -1.12748555253968 0.188839838334599 no 2793 0.129768622751533 960 269167
SGTC_2811 7967822 32.47 µM -1.12775428341909 0.188785819286732 no 2794 0.129711852720807 948 2232244
SGTC_809 3998-0021 90 µM -1.1288547105975 0.188564715824756 no 2795 0.129479564324082 965 715485
SGTC_1685 st024049 53.0905 µM -1.12949034152764 0.188437074384436 no 2796 0.129345520837907 956 1941139
SGTC_1257 0669-0121 16 µM -1.13259860960085 0.187813668891137 no 2797 0.128691426403096 944 4307855
SGTC_2683 piperine 63.03 µM -1.13354105903613 0.187624899755368 no 2798 0.128493554449814 964 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_344 k064-0035 6.43 µM -1.13358222208796 0.187616657620954 no 2799 0.128484916877821 930 5088750
SGTC_1775 st081588 35.1725 µM -1.13444109208026 0.187444735933887 no 2800 0.128304785255428 943 1426443 YGL099W LSG1
SGTC_2891 9063876 19.48 µM -1.13445140434541 0.187442672299344 no 2801 0.128302623520083 953 6472478
SGTC_3319 9138450 16.7555 µM -1.13739445118178 0.186854299702388 no 2802 0.127686712943403 935 2029690
SGTC_2363 9053361 176 µM -1.13790344967817 0.186752657004745 no 2803 0.127580400326979 965 6469797 YMR079W SEC14
SGTC_2129 girgensonine 121.053 µM -1.13837398751314 0.186658725025273 no 2804 0.127482175601727 966 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1650 st011916 45.8 µM -1.14072435790955 0.186189966113851 no 2805 0.126992323463317 976 242528
SGTC_3125 9127534 49.47 µM -1.14186695204478 0.185962350405836 no 2806 0.126754663693895 947 1639235
SGTC_2014 4013930 200 µM -1.14393724435857 0.185550368074847 no 2807 0.126324831876805 977 64556
SGTC_1907 st060210 83.7 µM -1.14405327274583 0.185527295527091 no 2808 0.126300772284389 964 688793
SGTC_286 k060-0067 22.9 µM -1.14423465498662 0.185491230762457 no 2809 0.126263167345535 963 5985051
SGTC_78 0336-0123 156.75 µM -1.14497621404039 0.185343829658732 no 2810 0.126109505332044 946 6765896
SGTC_920 mycophenolic acid 780.421 nM -1.14647322713208 0.185046487183381 no 2811 0.125799699405515 972 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_551 k048-0028 34.9 µM -1.14671007847789 0.184999470029177 no 2812 0.125750731848855 968 6836383
SGTC_1472 k841-0093 193 µM -1.14832951828937 0.184678195350015 no 2813 0.12541627889262 972 X1472
SGTC_153 4077-0274 519.67 µM -1.14855946621596 0.184632604971968 no 2814 0.125368839546621 939 3121976
SGTC_1698 5-fluorocytosine 1.055 µM -1.14955935326104 0.184434444829846 no 2815 0.125162703775609 955 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_897 1000-0139 31.4 µM -1.14973611305393 0.184399427893503 no 2816 0.125126287776262 970 6151020
SGTC_26 0302-0163 425.158 µM -1.15099746671264 0.18414966795264 no 2817 0.12486663886734 993 3100915
SGTC_2016 5121758 140 µM -1.15259260196391 0.183834117779164 no 2818 0.124538820594206 950 2795203
SGTC_2483 5729050 27.16 µM -1.15579408822111 0.183201815760095 no 2819 0.123882695865524 969 2865180
SGTC_1578 josamycin 24.2 µM -1.15848698086924 0.182671013975541 no 2820 0.123332680789066 973 5282165 A P450 substrate.
SGTC_887 0885-0007 9.62 µM -1.15893178788674 0.182583429618978 no 2821 0.123241995217078 976 5719458
SGTC_253 dyclonine 31.25 µM -1.1593823715878 0.182494734552789 no 2822 0.123150179567515 973 3180 An oral anasthetic.
SGTC_2480 5767542 37.17 µM -1.16002688464714 0.182367912286845 no 2823 0.123018930191742 948 2867358
SGTC_1849 st056239 19.2 µM -1.1610613991743 0.182164463726078 no 2824 0.12280846554935 952 5393181
SGTC_541 4513-1321 94 µM -1.16164711157102 0.182049339921303 no 2825 0.122689418534594 940 747515
SGTC_1634 st006576 41 µM -1.16312314722251 0.181759421804801 no 2826 0.122389770950891 953 3915356
SGTC_2539 epi(13)torulosol 80 µM -1.16402759965294 0.181581915005161 no 2827 0.122206413530413 958 6708597
SGTC_1409 3909-8004 61.9 µM -1.16413939660428 0.181559981399734 no 2828 0.122183762608283 969 2119279
SGTC_935 2996-0153 430 µM -1.16503458041844 0.18138441379435 no 2829 0.122002497775231 971 23738523
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.16593425606898 0.18120807236321 no 2830 0.121820513765539 985 6708784 An antioxidant flavonoid
SGTC_1192 1488-0095 21.4 µM -1.16826263494959 0.18075219590984 no 2831 0.12135042116259 987 915875
SGTC_1327 1436-0082 2.18 µM -1.16826333606484 0.180752058745912 no 2832 0.121350279801923 984 15992205
SGTC_2741 miltefosine 3.04 µM -1.16844238381977 0.180717032556332 no 2833 0.121314183521589 941 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1917 st066507 28.5 µM -1.16879705126359 0.180647663356701 no 2834 0.121242704355843 963 3156428
SGTC_942 3253-1115 227 µM -1.16954600562221 0.18050123067619 no 2835 0.12109185850061 969 46497897
SGTC_3339 9145883 14.936 µM -1.17092823100437 0.180231178841961 no 2836 0.120813813182622 931 2030670
SGTC_364 0083-0097 67.7 µM -1.17118731813363 0.180180588012653 no 2837 0.120761745850803 997 5207356
SGTC_2916 7875993 68.79 µM -1.17185915170922 0.180049443489782 no 2838 0.120626804697317 944 1299250
SGTC_456 gingerol 170 µM -1.17406197500522 0.179619864370181 no 2839 0.120185101377686 968 442793 A herb.
SGTC_1254 0550-0035 264 µM -1.17599827121393 0.179242793860922 no 2840 0.119797783444839 974 15121435
SGTC_454 lyso-paf C-16 6.67 µM -1.17747523248844 0.178955508279519 no 2841 0.119502938716444 967 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3068 9116768 49.47 µM -1.17804460744528 0.178844835871872 no 2842 0.119389411630662 966 41904888
SGTC_2898 9056270 58.44 µM -1.18131804010937 0.178209397635501 no 2843 0.118738201685591 920 19154699
SGTC_503 tyrphostin 8 294 µM -1.18230785337062 0.178017535774953 no 2844 0.118541785292015 1000 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2086 5274770 176.623 µM -1.18332730033579 0.177820066026123 no 2845 0.1183397285938 948 689278
SGTC_1036 k216-0215 33.5 µM -1.18357219678771 0.177772649484267 no 2846 0.118291225853854 896 622330
SGTC_2382 9035899 200 µM -1.18916609424227 0.176691738710281 no 2847 0.11718715691929 983 6462679
SGTC_2794 7785382 27.27 µM -1.19035655163306 0.176462243586106 no 2848 0.116953141182854 956 2205081
SGTC_1889 st059080 5.18 µM -1.19219523349183 0.176108155129442 no 2849 0.116592350987705 977 176925 Isolated from Daphnopsis sellowiana.
SGTC_1837 st055472 66.5 µM -1.19342784651835 0.175871033800706 no 2850 0.116350927303583 975 676091
SGTC_325 2810-4341 181 µM -1.19470066076857 0.175626391159443 no 2851 0.116102002104126 937 774970
SGTC_70 0141-0289 43.283 µM -1.19474316576127 0.175618225163837 no 2852 0.116093695899456 943 352408
SGTC_2206 7254556 146.969 µM -1.19685347517289 0.175213098210259 no 2853 0.115681835444155 966 4398905
SGTC_131 0141-0277 33.849 µM -1.19691148499396 0.175201970143296 no 2854 0.115670528580365 985 1547771
SGTC_2814 7977482 42.97 µM -1.19809146535601 0.174975710932081 no 2855 0.115440705527965 975 6456762
SGTC_1227 3909-8010 46.6 µM -1.20283828145753 0.174067391266639 no 2856 0.114519453815219 973 15982272
SGTC_1488 4013-0813 75.9 µM -1.20829500950595 0.173026937992351 no 2857 0.113466903687689 952 2910057
SGTC_2260 7964312 200 µM -1.20851405414988 0.172985254869301 no 2858 0.113424796591836 993 231951
SGTC_565 1418-0001 44.5 µM -1.20960496802634 0.172777754586007 no 2859 0.11321525545407 983 2862145
SGTC_438 sphingosine 6.67 µM -1.21023801510206 0.172657416892708 no 2860 0.113093787405282 987 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1660 st012960 28.1 µM -1.21377321156493 0.17198638421459 no 2861 0.112417169269082 973 24207266
SGTC_1315 1237-0019 3.69 µM -1.21818645192726 0.171151025756183 no 2862 0.111576563442289 957 825140
SGTC_1035 k081-0041 55.2 µM -1.22149017848027 0.170527382360407 no 2863 0.110950241013843 963 731709
SGTC_938 3126-1755 342 µM -1.22301632070634 0.170239784946275 no 2864 0.110661766015585 957 1777771
SGTC_460 trequinsin 123 µM -1.22384388992195 0.170083961766947 no 2865 0.110505561894934 1021 5537 A vasodilator.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.22574953206382 0.169725495723872 no 2866 0.110146472142525 982 688664
SGTC_3018 9082602 49.47 µM -1.22802830556169 0.169297477417759 no 2867 0.109718171234693 956 17332089
SGTC_222 nsc-310342 10.666 µM -1.2282470648576 0.169256424697989 no 2868 0.109677117886315 980 432556
SGTC_1224 0823-0416 294 µM -1.23023773708551 0.168883145670758 no 2869 0.109304046130998 970 3598164
SGTC_2324 6149169 200 µM -1.23075001397927 0.168787172180804 no 2870 0.109208188012058 975 2888231
SGTC_1077 5-fluorocytosine 377 nM -1.23094849504899 0.168749996788643 no 2871 0.109171064138571 981 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2489 cantharidin 73.42 µM -1.23100947724018 0.168738575915462 no 2872 0.109159659858742 960 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2523 spermine 47.74 µM -1.23244217441823 0.168470400300973 no 2873 0.108891977421771 958 1103 A DNA binding polyamine.
SGTC_482 fipronil 114 µM -1.23291187989542 0.168382539413127 no 2874 0.10880432133974 984 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_589 1227-0070 34.1 µM -1.24128206504724 0.166821795191355 no 2875 0.107250783883192 981 2841384
SGTC_2375 9072683 200 µM -1.24405872539995 0.16630611414611 no 2876 0.10673897516467 991 16798029
SGTC_3047 9092122 49.47 µM -1.24481094358617 0.166166589678651 no 2877 0.106600626248227 987 17173831
SGTC_1068 loratadine 26.9 µM -1.24496373178299 0.166138259148671 no 2878 0.10657254107333 1004 3957 A H1 histamine antagonist.
SGTC_2624 nerol 100 µM -1.24558838062131 0.166022467001723 no 2879 0.106457775118313 989 637566 A natural product oil.
SGTC_2748 diazoxide 86.69 µM -1.24662641075083 0.165830161069729 no 2880 0.10626725653107 941 3019 A potassium channel activatior.
SGTC_183 3914-0051 30.55 µM -1.24883340055922 0.165421771860886 no 2881 0.105863007375547 981 1596232
SGTC_1881 5652484 16 µM -1.25091034312733 0.165038041847446 no 2882 0.10548359491795 985 2255129
SGTC_1134 3477-0009 42.5 µM -1.25113312129341 0.164996916236873 no 2883 0.105442956645811 970 3973534
SGTC_2258 7960471 200 µM -1.25160181501246 0.164910415442389 no 2884 0.105357496451333 1003 2974708
SGTC_3139 9095020 49.47 µM -1.2525481024672 0.16473586081233 no 2885 0.105185105990851 931 25236292
SGTC_751 0833-0568 350 µM -1.25332038416166 0.164593492471801 no 2886 0.10504456646885 990 6954252
SGTC_2760 etidronate 98.04 µM -1.25440246422224 0.164394147683146 no 2887 0.1048478786671 976 3305 A chelator and antioxidant.
SGTC_3340 9146634 11.102 µM -1.25681678188593 0.163949937595021 no 2888 0.104409993881446 975 4907387
SGTC_1205 4161-2785 76 µM -1.25686544461936 0.163940992157578 no 2889 0.104401181566361 988 3498106
SGTC_2740 felodipine 17.08 µM -1.25918479799336 0.163515003799562 no 2890 0.103981795580921 981 3333 L-type calcium channel blocker
SGTC_1060 3448-7350 82 µM -1.26136946750222 0.163114410435501 no 2891 0.103587881743084 985 570178
SGTC_1404 3909-7820 48.3 µM -1.26222926883474 0.162956927459851 no 2892 0.103433149831593 936 23741373
SGTC_141 0443-0274 32.331 µM -1.26272228417039 0.162866670365999 no 2893 0.103344501322895 877 1627241
SGTC_622 1348-1566 26.3 µM -1.26464251262086 0.162515441049296 no 2894 0.102999753087189 979 7340407
SGTC_307 1501-1223 22.3 µM -1.26655571413981 0.162165987567547 no 2895 0.102657098019913 992 2830329
SGTC_1653 st012112 65 µM -1.27110965940463 0.161336162201258 no 2896 0.101844819709917 986 720429
SGTC_1092 toremifene 6.32 µM -1.27175561828244 0.161218679483409 no 2897 0.101729981203996 1006 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1810 st050138 53 µM -1.27275360754369 0.161037281562326 no 2898 0.101552744152877 1006 3444541
SGTC_1357 1503-1303 39.5 µM -1.27300307949167 0.160991957510908 no 2899 0.101508474548697 973 292895
SGTC_3178 9107506 49.47 µM -1.27694903386106 0.160276164174001 no 2900 0.100810120628782 982 8897194
SGTC_3040 9091894 49.47 µM -1.27864239301348 0.159969628850063 no 2901 0.100511507127597 962 25236966
SGTC_731 3966-0296 387 µM -1.27954237699652 0.159806868055943 no 2902 0.100353063353928 988 660956
SGTC_1098 clofazimine 15.1 µM -1.28048134425581 0.159637172709665 no 2903 0.100187950877079 993 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3185 9108267 49.47 µM -1.28094028056192 0.159554274126665 no 2904 0.100107321520101 984 4910486
SGTC_2472 5377652 49.4 µM -1.2823567932004 0.159298584342563 no 2905 0.0998587567946932 1006 1610903
SGTC_2910 7948405 25.97 µM -1.28286025405481 0.159207771037898 no 2906 0.0997705199052399 949 2971328
SGTC_1786 berberine 21.6 µM -1.28292525933963 0.159196047981328 no 2907 0.0997591311882687 944 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2955 9076254 12.21 µM -1.28410894314981 0.158982681262269 no 2908 0.0995519196578531 981 16459619
SGTC_46 0329-0187a 2.197 µM -1.28625998079664 0.158595422600177 no 2909 0.0991761720460066 984 46494817
SGTC_1970 st070122 35.8 µM -1.28634955340778 0.15857930996362 no 2910 0.0991605478446038 992 102928
SGTC_315 k915-0449 187 µM -1.28767193139847 0.158341560869622 no 2911 0.0989300941175432 986 20970215 YNL149C PGA2
SGTC_1298 1079-1278 263 µM -1.28813344670922 0.15825864054566 no 2912 0.0988497571378756 993 2840950
SGTC_2291 7917025 104.35 µM -1.29064101867293 0.157808603897864 no 2913 0.0984140927731288 989 2964612
SGTC_1010 4112-3296 15.2 µM -1.29183913278045 0.157593874092391 no 2914 0.0982064300868757 974 704384
SGTC_1935 st074532 41.6 µM -1.29412983571645 0.157183861708087 no 2915 0.0978102887005047 971 2829742
SGTC_1912 st060209 90.8 µM -1.29733444169977 0.156611448132215 no 2916 0.0972580693765673 1006 688787
SGTC_2545 solidagenone 89.61 µM -1.30004369512301 0.156128587314821 no 2917 0.0967929968265712 943 6708572 An anti ulcer agent
SGTC_323 4013-0906 34.3 µM -1.30506373705932 0.155236478232993 no 2918 0.0959355727170198 974 2910086
SGTC_998 3996-0085 177 µM -1.3052860114201 0.155197055912316 no 2919 0.0958977377692289 998 715391
SGTC_1611 st001856 99.4 µM -1.30716289348603 0.154864437828426 no 2920 0.0955786974096541 1010 647478
SGTC_3271 9137798 49.47 µM -1.30901967739785 0.154535845192408 no 2921 0.0952638426809041 939 6498326
SGTC_143 4032-1194 15.74 µM -1.30948700913341 0.154453214745551 no 2922 0.0951847176971718 988 1806963
SGTC_3326 9140064 16.379 µM -1.30972664189087 0.154410855827332 no 2923 0.0951441637132066 1005 1868434
SGTC_3041 9091929 49.47 µM -1.31013646892053 0.154338430153757 no 2924 0.0950748365826639 984 25236887
SGTC_1293 1000-1278 195 µM -1.31049232591941 0.154275560424065 no 2925 0.0950146693123391 993 678847
SGTC_1605 st000082 49.1 µM -1.31204124485176 0.154002108168259 no 2926 0.0947531092996905 963 1114022
SGTC_558 k064-0027 21.3 µM -1.31332081795872 0.153776449329259 no 2927 0.0945374332391784 984 5088526
SGTC_3249 9135183 49.47 µM -1.31778001252336 0.152991760291983 no 2928 0.0937886503585703 957 4902779
SGTC_479 n-linoleoylglycine 10 µM -1.31868858471828 0.152832204020349 no 2929 0.0936366223136503 1010 6433346 An anti-infammatory.
SGTC_392 N-ethylmaleimide 8.33 µM -1.31916298019322 0.152748938300992 no 2930 0.0935573158072594 982 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3248 9135562 49.47 µM -1.32449318136402 0.151815451870806 no 2931 0.0926696530674377 986 17650701
SGTC_1278 0874-0585 172 µM -1.3264917911436 0.1514664114044 no 2932 0.0923384262019426 1009 766306
SGTC_2065 5221596 34.26 µM -1.32758156785342 0.151276315991428 no 2933 0.0921581885207461 981 788581
SGTC_1569 carminic acid 40.6 µM -1.32876466594775 0.151070121772994 no 2934 0.0919628114519287 993 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2310 7668677 200 µM -1.33046410118943 0.150774266017758 no 2935 0.0916827033466949 996 2197143
SGTC_3222 9128301 49.47 µM -1.33052237531304 0.150764127884118 no 2936 0.0916731095809662 967 4911358
SGTC_1401 3807-4679 7.6 µM -1.33652505730539 0.149722253417654 no 2937 0.0906888580046678 985 3291456
SGTC_3345 9148410 3.559 µM -1.33761243485175 0.149534034401607 no 2938 0.0905114043906453 965 4903596
SGTC_2859 9028643 45.46 µM -1.33840589281507 0.149396790929404 no 2939 0.0903820794976411 958 17151580
SGTC_1938 st074717 56.4 µM -1.33890514159405 0.149310479579118 no 2940 0.0903007778156744 953 17250979
SGTC_1294 1000-1494 117 µM -1.34055324396053 0.149025788009176 no 2941 0.0900327731938735 999 712797 YDL207W GLE1
SGTC_44 0929-0055 61.211 µM -1.34066466606392 0.149006554160448 no 2942 0.0900146757445935 971 1379590
SGTC_491 tetrandrine 80.3 µM -1.34282012475298 0.148634802027978 no 2943 0.0896651126328752 1007 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2941 9056145 11.23 µM -1.34363872461801 0.148493780636095 no 2944 0.089532620370737 984 2119517
SGTC_2886 9058944 51.95 µM -1.34627811555597 0.148039698387088 no 2945 0.0891064204260335 980 4949929
SGTC_3195 9113082 49.47 µM -1.34742869073019 0.147842043972645 no 2946 0.0889211027139458 1016 17018038
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.3478027306118 0.147777826676062 no 2947 0.0888609197183777 987 23665772 A membrane-active detergent.
SGTC_1530 rhein 70.4 µM -1.34811504257735 0.147724221490374 no 2948 0.088810691978163 994 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1332 1480-0653 17.5 µM -1.35173363805167 0.147104075780071 no 2949 0.0882302700553737 999 5749438
SGTC_1331 1472-0049 76.2 µM -1.35368374649122 0.146770595980082 no 2950 0.0879186478869719 997 24051409
SGTC_2088 5278280 127.392 µM -1.3544587507295 0.146638206726766 no 2951 0.0877950324400161 995 791502
SGTC_1969 st069479 40.1 µM -1.35480398517311 0.146579258237608 no 2952 0.0877400082926238 995 3895485
SGTC_2593 nobiletin 86.24 µM -1.3564008264295 0.146306805876033 no 2953 0.0874858352369368 985 72344 An anti-infammatory.
SGTC_2713 st079149 53.4 µM -1.35781055661719 0.146066561117949 no 2954 0.0872619021660941 1003 3103253
SGTC_1118 chelidonine 707.474 nM -1.36005223588989 0.145685082516469 no 2955 0.0869066972279303 1010 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2430 5571206 200 µM -1.36141066316356 0.145454237862955 no 2956 0.0866919741074313 997 1731771
SGTC_1186 1319-0216 26 µM -1.36341498373876 0.145114082696102 no 2957 0.0863758807273792 999 4565136
SGTC_2829 7992743 58.44 µM -1.36434936154286 0.144955691651498 no 2958 0.0862288186099175 1004 16462845
SGTC_290 2043-6722 48.1 µM -1.36911212263706 0.144150141307454 no 2959 0.0854821147500045 1006 773758 YLR208W SEC13
SGTC_2038 4100038 30.985 µM -1.37416513554493 0.143298804965195 no 2960 0.0846952108750481 976 3596803
SGTC_199 4063-0024 41.6 µM -1.37657356935948 0.142894227063937 no 2961 0.0843220635928266 1020 306215
SGTC_66 0109-0187 42.4 µM -1.37689388503918 0.142840477434132 no 2962 0.0842725290331432 987 759417
SGTC_3129 9127257 49.47 µM -1.38057500124851 0.142223759489653 no 2963 0.0837048370740748 1004 837894
SGTC_136 0097-0015 404.482 µM -1.38360887800496 0.141716833567933 no 2964 0.0832391242022502 1013 4861337
SGTC_249 wiskostatin 11.211 µM -1.38383161512664 0.141679665039171 no 2965 0.0832050100316572 980 2775510 A n-wasp and actin depolymerizer.
SGTC_2384 9036245 200 µM -1.38386678426215 0.141673796908383 no 2966 0.0831996245269606 971 6462766
SGTC_1114 scopoletin 1.73284 µM -1.38757538689046 0.141055923578254 no 2967 0.0826331903024158 1017 5280460 A coumarin with genotoxic properties.
SGTC_3111 9122088 49.47 µM -1.38803059515415 0.140980209524418 no 2968 0.0825638644463194 995 16876704
SGTC_2852 9023854 51.95 µM -1.38848603727707 0.140904484164629 no 2969 0.0824945467976433 1010 19798528
SGTC_266 formosanin C 406 nM -1.39235738496439 0.14026191784709 no 2970 0.0819071011381628 971 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2887 9044784 58.44 µM -1.39424392672825 0.139949511973651 no 2971 0.0816219786345848 997 6465546
SGTC_1684 st024538 14.6195 µM -1.39536703315523 0.139763753506931 no 2972 0.0814525936611688 1017 6732859
SGTC_1561 5-methoxyflavone 52.9 µM -1.39678608175264 0.139529286871108 no 2973 0.0812389544648741 983 94525
SGTC_1408 3909-7976 48.8 µM -1.39760938233873 0.139393377214863 no 2974 0.0811151996747654 1004 24152374
SGTC_2411 st077133 39.94 µM -1.39889225355221 0.139181781638483 no 2975 0.080922647946148 1012 1403142 YNL221C POP1
SGTC_1827 berberine 7.24 µM -1.40044642813745 0.138925730500019 no 2976 0.0806898375663077 970 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_530 4358-1714 28 µM -1.40140761380578 0.138767535234683 no 2977 0.0805461083857371 989 1564641
SGTC_2093 5331342 194.4 µM -1.40163661676282 0.13872986323963 no 2978 0.0805118933815978 1009 33839
SGTC_2470 5664817 21.68 µM -1.40428331902784 0.138294974548375 no 2979 0.0801172497617552 1022 2859561
SGTC_1187 1391-0724 117 µM -1.40531598799297 0.138125545487895 no 2980 0.079963668098328 1019 6997986
SGTC_763 3453-1109 128 µM -1.41368763471956 0.136757242250551 no 2981 0.0787268187764422 1006 1560353
SGTC_3149 9097855 49.47 µM -1.41471074350204 0.136590657948594 no 2982 0.0785766615480824 999 25236625 YMR079W SEC14
SGTC_495 decylubiquinone 155 µM -1.41498797568444 0.136545542440669 no 2983 0.0785360107904586 1009 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2195 6536160 144.242 µM -1.41553657570724 0.136456295800918 no 2984 0.0784556161554729 1009 3834386
SGTC_2442 5158906 48.48 µM -1.41648592088223 0.136301949939153 no 2985 0.0783166417150552 1000 1893835
SGTC_1695 st026914 34.495 µM -1.41758322261251 0.136123697972124 no 2986 0.078156240623367 1021 3289191
SGTC_1367 1812-0510 76.9 µM -1.42005752375965 0.135722344060512 no 2987 0.0777954674724973 998 1142582 YDR527W RBA50
SGTC_1001 4048-4355 44.4 µM -1.42136240329349 0.135511007625284 no 2988 0.0776057152473232 1004 21824233
SGTC_1152 3909-8331 15.9 µM -1.42164755526652 0.135464854854784 no 2989 0.0775642960057954 994 16001939
SGTC_1664 st014217 9.02 µM -1.42736908510428 0.134541082765584 no 2990 0.0767367684586672 985 3982782
SGTC_852 0418-0143 439 µM -1.42878071212644 0.134313834531889 no 2991 0.0765336354804658 963 5369229
SGTC_1790 st045711 43.5 µM -1.43054317943659 0.134030477098187 no 2992 0.0762805910850245 975 585119
SGTC_1888 azatryptophan 97.5 µM -1.43730899852005 0.132946531356669 no 2993 0.0753151065570964 1006 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1755 st041960 45.185 µM -1.43789480465457 0.132852964594353 no 2994 0.0752319520195558 1018 2257073
SGTC_297 0986-0032 24 µM -1.43846910652437 0.132761279355683 no 2995 0.0751504984648863 1009 2847425
SGTC_874 0599-0792 117 µM -1.44137562382405 0.132297932674498 no 2996 0.0747392965072403 998 765305
SGTC_2213 7173844 200 µM -1.44481393237884 0.131751250465557 no 2997 0.0742550782929951 1016 892728
SGTC_51 1013-0126 23.419 µM -1.44649489388444 0.13148454997891 no 2998 0.0740192215764287 1011 1627850
SGTC_2125 5246583 200 µM -1.44826791030982 0.13120364821497 no 2999 0.0737710692644502 1031 835267
SGTC_516 3992-2719 87.3 µM -1.44867664173597 0.131138951088274 no 3000 0.073713953292995 1030 5350887 YDR037W KRS1
SGTC_680 0417-1641 114 µM -1.4527319648468 0.130498237537427 no 3001 0.0731490941580807 1018 2835990
SGTC_3168 9103419 49.47 µM -1.45593885559183 0.129993105795724 no 3002 0.0727047615792885 1021 16649256
SGTC_2572 astragaloside iv 100 µM -1.45718121511838 0.129797780379092 no 3003 0.0725331822596082 1009 45006101 An anti-inflammatory agent.
SGTC_1360 1598-0022 39.8 µM -1.45824631655063 0.129630485595841 no 3004 0.0723863307226789 1026 761525
SGTC_2993 9054257 71.4286 µM -1.45853630190441 0.129584963665348 no 3005 0.0723463882880683 999 6470217 YGL055W OLE1
SGTC_579 4491-1009 110 µM -1.46102280231895 0.129195087129058 no 3006 0.0720045919241342 1034 1271041
SGTC_1033 k072-0102 21.3 µM -1.46320594673816 0.128853447013455 no 3007 0.0717055170427915 999 5965931
SGTC_451 chloral hydrate 100 µM -1.46361812500612 0.128789015655637 no 3008 0.071649158714434 1016 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_946 3434-1334 87.4 µM -1.46537650024457 0.128514399000966 no 3009 0.0714091126292254 1003 4047976
SGTC_20 0481-0013 4.944 µM -1.47645595352584 0.126793399298512 no 3010 0.0699107656565184 1002 182045
SGTC_1999 st074831 12.5 µM -1.47728422286785 0.126665389817672 no 3011 0.069799732677482 1014 17112523
SGTC_649 1123-0311 367 µM -1.47880953453555 0.126429887614188 no 3012 0.0695956134372065 1009 693629 YIL048W NEO1
SGTC_870 0573-2213 57.6 µM -1.47882266942315 0.126427860964181 no 3013 0.0695938577070735 1020 3916321
SGTC_2247 cerulenin 830 nM -1.47946399137882 0.126328935600808 no 3014 0.0695081741798259 999 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2659 sanguinarine 24.21 µM -1.48009845231828 0.126231121654392 no 3015 0.0694234872753855 977 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1798 st045719 60.953 µM -1.48128644184374 0.126048112967426 no 3016 0.0692651299300798 989 3980186
SGTC_2466 5983409 37.09 µM -1.48410233748844 0.125615065976306 no 3017 0.0688908866023554 1034 2879657
SGTC_2076 5212012 200 µM -1.49052703223131 0.124630923305237 no 3018 0.0680428570680807 1017 604802
SGTC_2178 5812956 200 µM -1.49136176027545 0.124503455326973 no 3019 0.0679332710403577 1016 5403383
SGTC_349 k015-0014 24 µM -1.49402313470819 0.124097656180059 no 3020 0.0675847863043206 1018 2196908
SGTC_14 0354-0009 295 µM -1.49476914896107 0.123984072195472 no 3021 0.0674873502522337 1030 1713507
SGTC_1779 st039427 55 µM -1.50156703548785 0.122952415160348 no 3022 0.066604481028859 1018 1124498
SGTC_3124 9127567 49.47 µM -1.50843160656766 0.121916760616007 no 3023 0.0657220494017835 1003 17592030
SGTC_2824 7998404 51.95 µM -1.51253260204013 0.121300977226808 no 3024 0.0651992126420179 1022 837851
SGTC_3114 9122766 49.47 µM -1.51500059502222 0.120931452574598 no 3025 0.0648861267154599 989 17176985
SGTC_860 0443-0016 25.1 µM -1.51853356390218 0.12040385222641 no 3026 0.0644399724426102 1027 5337942
SGTC_937 3122-0005 46.7 µM -1.51868153006524 0.120381790941 no 3027 0.0644213389498632 1011 759535
SGTC_81 0411-0046 9.971 µM -1.51930515535209 0.120288841677909 no 3028 0.0643428513391876 1010 12925265
SGTC_820 1582-0060 59.9 µM -1.52009719137505 0.12017086425704 no 3029 0.0642432752022233 1024 3848840
SGTC_1198 1612-1005 86.7 µM -1.52105662266696 0.120028061770775 no 3030 0.0641228143097212 1023 6998509
SGTC_2464 5717415 7.67 µM -1.52279443554333 0.11976970898035 no 3031 0.0639050712792256 1022 5285744
SGTC_1796 st049173 110.4 µM -1.52347705410028 0.119668334504297 no 3032 0.0638196985717061 1018 94134
SGTC_409 arachidonic acid 100 µM -1.52527515738469 0.119401591056622 no 3033 0.0635952406975365 1019 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_811 0416-0114 265 µM -1.52710019770002 0.119131280870902 no 3034 0.0633680488976614 1018 6612453
SGTC_3226 9131256 49.47 µM -1.5288974536834 0.118865508346412 no 3035 0.063144933800779 1002 17178073
SGTC_1426 4048-4480 71.7 µM -1.53120545279254 0.118524823308629 no 3036 0.0628593117942107 1026 14224343
SGTC_12 0849-0099 9.267 µM -1.53445368355306 0.118046520060517 no 3037 0.0624590396952354 1021 6071388
SGTC_1701 st028638 40.4 µM -1.53486499556688 0.117986051728603 no 3038 0.0624084967226717 1036 3490878
SGTC_1173 0443-0020 122 µM -1.53760197843517 0.117584236857909 no 3039 0.0620729817183381 1034 5331295
SGTC_1347 1493-0251 600 nM -1.53855817855867 0.11744408626849 no 3040 0.0619560975324628 965 3986378
SGTC_2813 7971799 71.43 µM -1.53965859529517 0.117282944237295 no 3041 0.0618217972158666 1025 2234054
SGTC_198 3454-2873 16.191 µM -1.54171800491384 0.116981790815277 no 3042 0.0615710673524134 1018 710957
SGTC_2926 9010726 65.15 µM -1.541867372106 0.116959969752981 no 3043 0.06155291306467 1030 2994293
SGTC_21 0849-0113 22.993 µM -1.54222992064292 0.116907017013583 no 3044 0.0615088658191029 1032 1560156
SGTC_1641 st009299 47.1 µM -1.54531508545629 0.116457094652492 no 3045 0.0611350341536165 1024 4046054
SGTC_2350 9023895 38.85 µM -1.54677949607066 0.1162439639956 no 3046 0.0609582130322389 1011 2997209
SGTC_539 4859-0462 2.54 µM -1.54906658241401 0.115911654875814 no 3047 0.0606828575706352 1004 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_796 1234-0020 70.7 µM -1.55100074036371 0.115631152416428 no 3048 0.0604507532676782 996 46495034
SGTC_2451 5856223 45.7 µM -1.55205116817514 0.115479015683934 no 3049 0.0603249904243322 1018 2179896
SGTC_2075 5212009 200 µM -1.55380917840112 0.115224715904696 no 3050 0.0601149702735799 1028 780898
SGTC_2061 5245884 80.95 µM -1.55427354825567 0.115157610370917 no 3051 0.06005959016186 1048 573863
SGTC_1354 1498-1681 81 µM -1.55920433469969 0.114446781809785 no 3052 0.0594740126153265 1042 5754243
SGTC_1435 4092-0789 56.7 µM -1.56093320518657 0.114198286734488 no 3053 0.0592697558331643 1022 2248285
SGTC_2032 5185112 25.99 µM -1.56161357067624 0.114100601464924 no 3054 0.0591895252853992 1015 5718189
SGTC_3250 9135583 49.47 µM -1.57009218787943 0.112888251851221 no 3055 0.058196832887389 1033 7699353
SGTC_810 3825-7150 143 µM -1.57204860318942 0.112609816366671 no 3056 0.0579696399135602 999 22330411 YGL099W LSG1
SGTC_1893 st059353 36.1 µM -1.5730431845381 0.112468456536316 no 3057 0.0578544095683481 1032 3112488
SGTC_847 0342-0274 5.54 µM -1.57388820984886 0.112348452747696 no 3058 0.0577566480583719 1027 18097
SGTC_944 3370-0224 231 µM -1.57395107104075 0.112339529357658 no 3059 0.0577493808011859 1021 4580514
SGTC_389 tpck 16.7 µM -1.57683342731839 0.111930911559764 no 3060 0.0574169289633597 1045 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_223 busulfan 5 mM -1.57830381325529 0.111722871863737 no 3061 0.0572479151559102 1029 2478 A DNA alkylator.
SGTC_3314 9135860 59.4275 µM -1.57853815752648 0.111689740894211 no 3062 0.0572210146163286 1006 25252478
SGTC_2960 9079389 5.97 µM -1.57920040977225 0.111596151431544 no 3063 0.0571450480060039 1030 16457355
SGTC_747 3448-8087 38.7 µM -1.58173553566895 0.111238406076479 no 3064 0.056854978392803 1050 5168703
SGTC_2256 7954252 200 µM -1.58198628283189 0.111203066457787 no 3065 0.0568263509838152 1051 2972920
SGTC_2479 5617353 43.85 µM -1.58331059609805 0.111016554709394 no 3066 0.0566753444887366 1024 2731746
SGTC_2575 plumbagin 510 nM -1.58423012731131 0.110887182941264 no 3067 0.0565706798596213 1022 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2629 bisabolol 100 µM -1.58898001604872 0.110220625793504 no 3068 0.056032452248619 1041 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_186 3455-3465 67.277 µM -1.58933178871397 0.110171375687569 no 3069 0.0559927527577464 1022 755278
SGTC_614 0462-0418 107 µM -1.59024226379541 0.110043977479478 no 3070 0.0558901036289891 1012 5188303
SGTC_476 mead acid 10 µM -1.59102506085608 0.109934529146124 no 3071 0.0558019679650874 1053 5312531 An omega 9 fatty acid.
SGTC_123 0083-0120 66.675 µM -1.59134022503477 0.109890485900785 no 3072 0.0557665143907042 1050 16001701
SGTC_1507 4075-3230 155 µM -1.59857525201068 0.108882892613297 no 3073 0.0549575061463021 1025 659771
SGTC_1193 1488-0126 41.5 µM -1.59925650985223 0.108788359829419 no 3074 0.0548818093108179 1028 1384710
SGTC_1117 retinoic acid 1.10837 µM -1.59959371247484 0.108741590718691 no 3075 0.0548443721006243 1055 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3137 9097352 49.47 µM -1.5997997242211 0.10871302455116 no 3076 0.0548215100156137 1011 44120435
SGTC_2284 7945075 39.21 µM -1.6009989302112 0.108546846415519 no 3077 0.0546885780449055 1017 1245402
SGTC_218 alverine citrate 93.75 µM -1.60168116591228 0.108452388235307 no 3078 0.0546130660343906 1022 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3190 9110366 49.47 µM -1.60526379120274 0.107957330504677 no 3079 0.0542178820481965 1036 17123768
SGTC_2204 7233102 200 µM -1.60534694838172 0.10794585895658 no 3080 0.0542087362794361 1023 2172480
SGTC_2775 cyproheptadine 69.59 µM -1.60974841995631 0.107339927434806 no 3081 0.0537263948708411 1030 2913 A selective serotonin reuptake inhibitor.
SGTC_570 0987-0065 62.6 µM -1.61117301463284 0.107144335883428 no 3082 0.0535710088690531 1003 3104428
SGTC_1922 5578187 25 µM -1.61217109488071 0.107007456372644 no 3083 0.0534623566849349 1002 1350412
SGTC_3032 9089427 49.47 µM -1.61938746314598 0.106021535182574 no 3084 0.0526819612824036 982 17173707
SGTC_629 3448-6466 76.7 µM -1.61942371822868 0.106016598534423 no 3085 0.0526780635154347 1045 573744
SGTC_2696 st077691 74.316 µM -1.62570494972913 0.105163824407174 no 3086 0.0520062182992659 1032 757133
SGTC_1496 4469-0713 57.4 µM -1.63282830344395 0.104202738829831 no 3087 0.0512525562813174 1051 746691
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.63445005987417 0.103984823411725 no 3088 0.0510821921289516 1038 4213774
SGTC_1048 3161-0300 24.5 µM -1.63492696127645 0.103920805090619 no 3089 0.0510321798784701 1022 2165101
SGTC_1902 st060212 70.5 µM -1.63689725283639 0.103656619955909 no 3090 0.050825970028868 1015 688944
SGTC_3021 9087658 49.47 µM -1.64110427332817 0.103094156430611 no 3091 0.0503878859231407 1030 25237042
SGTC_230 MPP+ 141.667 µM -1.64575954892384 0.102474350050799 no 3092 0.0499066367480132 1042 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2112 5488546 200 µM -1.64582283872739 0.102465942313994 no 3093 0.0499001193750499 1050 600757
SGTC_749 1000-0129 128 µM -1.65437065653495 0.101335010892909 no 3094 0.0490261123830845 1042 708470
SGTC_2645 abamectin 100 µM -1.65753848717122 0.100918204493196 no 3095 0.0487053271915199 961 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2174 5790901 200 µM -1.66151884384465 0.100396263914589 no 3096 0.0483046437713678 1034 786020
SGTC_1324 1418-0026 34.4 µM -1.66202828980037 0.100329603181866 no 3097 0.0482535511768159 1054 1372513
SGTC_1406 3909-7906 11.9 µM -1.6709304467229 0.0991699701462225 no 3098 0.0473677084109153 1003 X1406
SGTC_1350 1495-0454 146 µM -1.6780005622151 0.0982559936475598 no 3099 0.0466734946296668 1049 1069057
SGTC_1017 4239-0030 168 µM -1.67896576024008 0.0981316996081393 no 3100 0.0465793584961411 1038 1149593
SGTC_599 1935-0052 86.5 µM -1.68360402380657 0.0975360106461261 no 3101 0.0461291102881575 1047 9557311
SGTC_2090 5301565 104.445 µM -1.68571521916629 0.097265751259876 no 3102 0.0459253320417332 1043 2056344
SGTC_1011 4112-3381 17.4 µM -1.70127363196765 0.0952910074608746 no 3103 0.0444458084623853 1033 2877139
SGTC_1264 0783-0040 158 µM -1.70127984183266 0.0952902252143267 no 3104 0.0444452256970251 1038 2855798
SGTC_1333 1482-0047 286 µM -1.70361538694348 0.0949963555853181 no 3105 0.0442264824720071 1045 3811116
SGTC_259 usnic acid 108.925 µM -1.70422688592592 0.0949195242078374 no 3106 0.0441693540833244 1064 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2843 9000894 45.46 µM -1.70458909828502 0.0948740358756118 no 3107 0.0441355429937492 1024 2242070
SGTC_523 1934-0222 13.7 µM -1.70857056356912 0.094375082955522 no 3108 0.0437652625914609 1052 1361595
SGTC_1715 st032160 10.2275 µM -1.71047929743225 0.0941365698480505 no 3109 0.0435886392559724 1034 5289825
SGTC_3254 9136651 49.47 µM -1.71215905638822 0.0939270373119291 no 3110 0.0434336802484388 1057 16454030
SGTC_1252 0493-0875 34.8 µM -1.71486396303686 0.0935903519278424 no 3111 0.0431850855408251 1033 3960963
SGTC_1882 5615643 20 µM -1.71749958606461 0.0932631484884549 no 3112 0.0429439650032468 1007 2253075
SGTC_3086 9117350 49.47 µM -1.71928692464344 0.0930417380558349 no 3113 0.0427810698109991 1030 2679265
SGTC_473 2-arachidonoylglycerol 10 µM -1.72116535923425 0.0928094618952829 no 3114 0.0426104109140519 1004 5282280 An endocannabinoid.
SGTC_2608 thymoquinone 42.66 µM -1.72515973322601 0.0923169669520406 no 3115 0.0422493450669704 1040 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2540 epiandrosterone 100 µM -1.73206549715644 0.0914700728898239 no 3116 0.041630950739277 1045 441302 A steroid.
SGTC_2476 5806916 10.51 µM -1.73254890198378 0.09141100650393 no 3117 0.0415879390542374 1008 2870194
SGTC_2644 guaiazulene 100 µM -1.73408110460185 0.0912239761891272 no 3118 0.041451846825099 1034 3515 A coloring agent.
SGTC_2703 st077852 53.4 µM -1.73639395956212 0.0909421921789098 no 3119 0.04124709979398 1028 6281836
SGTC_2551 apiole 73.87 µM -1.73680301465465 0.090892422697295 no 3120 0.0412109733840208 1050 10659 A possible DNA adduct former.
SGTC_2462 5162487 171.77 µM -1.75002675650926 0.0892943651977479 no 3121 0.0400568484379825 1063 2259986
SGTC_1150 3909-7983 10.9 µM -1.75194135915802 0.0890647332054322 no 3122 0.039891945906196 1049 23965914
SGTC_720 r052-1644 49.9 µM -1.75465907555993 0.088739533173581 no 3123 0.039658820034975 1051 1422863 YOR257W CDC31
SGTC_2914 7968218 45.32 µM -1.75638239378128 0.0885337807547512 no 3124 0.0395115685202498 1027 2977111
SGTC_1492 4158-0558 28.5 µM -1.7568410832908 0.0884790762946707 no 3125 0.0394724501330854 1030 3967268
SGTC_2328 6201408 200 µM -1.75842707610799 0.0882901208926458 no 3126 0.0393374347419969 1043 2890418
SGTC_270 tamoxifen 5.46 µM -1.76110212265999 0.0879720971559637 no 3127 0.0391105599175695 1074 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2323 6148992 148.28 µM -1.76222153820843 0.0878392689078559 no 3128 0.0390159372208273 1033 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.77157557890437 0.0867351742378758 no 3129 0.038232518252641 1007 688669
SGTC_229 benomyl 22.8748 µM -1.77240741076456 0.0866374942187794 no 3130 0.0381634762585911 1042 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_610 4215-0184 155 µM -1.78388155960774 0.085298490091403 no 3131 0.0372214564733709 1016 5605015
SGTC_1807 st050092 58.9 µM -1.78734748885131 0.0848970895635621 no 3132 0.036940671543202 1057 5008496
SGTC_2099 5377090 177.372 µM -1.79032515593402 0.0845533686026763 no 3133 0.0367008272342514 1042 2243829
SGTC_702 1488-0190 94 µM -1.79433737616877 0.0840918784378765 no 3134 0.03637966791915 1053 949357
SGTC_3219 9131112 49.47 µM -1.79473268635382 0.0840465119403694 no 3135 0.0363481500636226 1011 17612988 YMR079W SEC14
SGTC_2114 5491910 81.25 µM -1.79911344223845 0.0835449981353266 no 3136 0.036000368857335 1053 2849228
SGTC_1120 ficusin 1.78878 µM -1.80078032732724 0.0833547630398122 no 3137 0.0358687553991488 1055 6199 A DNA cross-linker.
SGTC_3182 9108849 49.47 µM -1.80316025085894 0.0830837162390475 no 3138 0.0356815255180914 1047 17133045
SGTC_2707 st078556 66.6 µM -1.8052430952799 0.0828470477994143 no 3139 0.0355183249726868 1031 17250899
SGTC_2048 5246248 200 µM -1.80631746913522 0.0827251678325983 no 3140 0.0354343823357103 1042 677046
SGTC_685 1278-0033 54.9 µM -1.81061566461356 0.082238918012221 no 3141 0.0351001828389871 1054 3590572
SGTC_160 3453-0671 289.699 µM -1.8110295954488 0.0821922043747808 no 3142 0.0350681352780205 1054 5322268
SGTC_3039 9090270 49.47 µM -1.81287648586382 0.0819840194147771 no 3143 0.034925436847264 1037 17173750
SGTC_234 nsc-17383 10.7 µM -1.81558762944101 0.081679134280831 no 3144 0.0347168263219671 1039 408974
SGTC_1520 flindersine 88 µM -1.81815334820701 0.0813913910517753 no 3145 0.0345203490323095 1026 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3287 9117173 37.0625 µM -1.81952935915086 0.0812373878851215 no 3146 0.0344153539319516 1011 2789709
SGTC_3081 9117243 49.47 µM -1.82257662951919 0.0808971200165915 no 3147 0.0341837689574716 1058 45595589
SGTC_1244 0416-0015 52.5 µM -1.83118395900008 0.0799418104371677 no 3148 0.0335365450776978 1062 96201
SGTC_877 0771-0151 33.1 µM -1.84301661266038 0.0786424855521626 no 3149 0.0326632924965415 1065 6166523
SGTC_943 3253-1379 105 µM -1.84972047329423 0.0779134824728962 no 3150 0.0321769240616656 1032 668464
SGTC_433 pimozide 108 µM -1.85543767679139 0.0772958335097153 no 3151 0.0317668756499187 1058 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_196 k015-0023 18.111 µM -1.86350322778607 0.0764308190175774 no 3152 0.0311957494194875 1055 5211998
SGTC_694 1315-0438 43.2 µM -1.86392824616849 0.0763854417361135 no 3153 0.0311658907350924 1056 6793154
SGTC_866 0495-0101 262 µM -1.86634247638549 0.0761280741739245 no 3154 0.030996732788214 1031 635694
SGTC_2646 retinol 96.75 µM -1.86788452253886 0.07596403106147 no 3155 0.0308890843422493 1040 445354 A vitamin A analog and teratogen.
SGTC_1090 efavirenz 20.7 µM -1.87511459664471 0.0751984821445659 no 3156 0.0303884799356761 1061 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_933 2914-0560 114 µM -1.87915183141945 0.0747735707399442 no 3157 0.030111882290986 1049 463887
SGTC_1783 st039459 87.517 µM -1.88082917353641 0.0745975732497778 no 3158 0.0299975801427259 1061 729761
SGTC_1142 3253-1408 9.78 µM -1.88183844650686 0.0744918263204254 no 3159 0.0299289769797213 1076 256655
SGTC_3034 9090421 49.47 µM -1.88248450857938 0.0744241950354187 no 3160 0.0298851306425747 1051 17173761
SGTC_1768 st044301 37.178 µM -1.88372307273577 0.0742946703459235 no 3161 0.0298012219062722 1069 3931349
SGTC_415 dibenzyl ketone 100 µM -1.88449687814299 0.0742138359059052 no 3162 0.0297488983455857 1056 7593
SGTC_1494 4358-1428 177 µM -1.885692699439 0.0740890483346666 no 3163 0.029668188631336 1052 1564571
SGTC_1667 st014849 34.6 µM -1.88645088620977 0.0740100123220149 no 3164 0.0296171104268805 1055 5348460
SGTC_1161 k007-0610 110 µM -1.88675696239375 0.0739781241390515 no 3165 0.0295965111014043 1031 5843850
SGTC_982 1491-0518 27.5 µM -1.89236434980814 0.0733957813541983 no 3166 0.0292212262706532 1056 3091256
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.89264903190351 0.0733663101137876 no 3167 0.0292022793050754 1074 688801
SGTC_2226 7298446 200 µM -1.89302965261157 0.0733269211301784 no 3168 0.0291769631063428 1061 3283010
SGTC_753 1322-0200 289 µM -1.894885884267 0.0731350585785493 no 3169 0.0290537608280208 1075 5403907
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.89563486937289 0.0730577513499956 no 3170 0.0290041715482159 1053 17037758
SGTC_2994 9053520 71.4286 µM -1.89794357849645 0.0728198491521111 no 3171 0.0288517574434279 1049 4647384
SGTC_3303 9125618 40.5795 µM -1.90648787095248 0.071944555018835 no 3172 0.0282934689232595 1042 22695467
SGTC_1270 0831-1170 17.3 µM -1.9091121941502 0.071677340038573 no 3173 0.0281238100056617 1051 6764716
SGTC_163 TUB2.036 7.546 µM -1.91209561748631 0.0713744861225749 no 3174 0.0279319654385351 1032 15992207 YJR013W GPI14
SGTC_462 ag-879 158 µM -1.91486203721464 0.0710945392396059 no 3175 0.0277550501626942 1062 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1762 st045503 25.4615 µM -1.91674392130067 0.0709045850457766 no 3176 0.0276352362201716 1067 4645554
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.9209591161941 0.0704805252865085 no 3177 0.0273684309721017 1052 165506
SGTC_1856 st057054 55.7 µM -1.92271600312378 0.0703043545532926 no 3178 0.0272578629692305 1050 1266018
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.9304981371092 0.0695280754149766 no 3179 0.0267725729067236 1048 6708630 An antioxidant.
SGTC_1379 2144-0755 36.5 µM -1.93409733538841 0.0691712899364134 no 3180 0.0265505807455901 1044 5392327
SGTC_2825 7998094 58.44 µM -1.9368271322953 0.0689016294712824 no 3181 0.0263832390535131 1065 2987815
SGTC_2983 9022671 12.99 µM -1.93749880403051 0.0688354033926784 no 3182 0.0263421997156074 1056 6405161
SGTC_2776 terbinafine 19.92 µM -1.93898368684455 0.0686891697955884 no 3183 0.0262516622914058 1041 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_903 1134-0042 114 µM -1.93946970324204 0.0686413582108767 no 3184 0.0262220850921347 1059 701009
SGTC_1030 k029-0042 36.7 µM -1.93992454297718 0.068596636865799 no 3185 0.0261944304348084 1050 6080581
SGTC_420 mitomycin C 81.9 mM -1.94344135672019 0.0682516104098704 no 3186 0.0259814272266259 1047 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3270 9137563 49.47 µM -1.944671523771 0.0681312382605459 no 3187 0.0259072624615317 1050 17015724
SGTC_2937 9044753 11.33 µM -1.94594126741348 0.0680071654681771 no 3188 0.0258308975383395 1044 6465530 YGL099W LSG1
SGTC_1865 st057639 52.2 µM -1.94613283917844 0.0679884612198083 no 3189 0.0258193923987675 1065 688818
SGTC_18 0111-0177 500 nM -1.94642127628601 0.0679603069460312 no 3190 0.0258020779498943 1077 721752
SGTC_1135 dihydrocapsaicin 536.708 nM -1.94907073646646 0.0677021147731769 no 3191 0.0256434889064328 1061 107982 A Capsaicinoid.
SGTC_2815 7968870 71.43 µM -1.95598076300547 0.0670322920755486 no 3192 0.0252337101409247 1067 2977326 YHR190W ERG9
SGTC_142 0335-0849 62.6745 µM -1.95738288860388 0.0668970048172286 no 3193 0.0251512343783222 1048 3889043 YPR107C YTH1
SGTC_3264 9137442 49.47 µM -1.9645373824987 0.0662099735921081 no 3194 0.0247339027557504 1041 17015726
SGTC_3230 9131665 49.47 µM -1.96669212666933 0.0660041323854533 no 3195 0.0246093575659626 1044 15943720
SGTC_2823 7987624 58.44 µM -1.97094637980156 0.0655991828402171 no 3196 0.0243650046619327 1050 2239440
SGTC_2721 ifenprodil 61.44 µM -1.97106221858185 0.0655881834968689 no 3197 0.0243583797843474 1052 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2899 9053889 58.44 µM -1.97296494264159 0.0654077170281342 no 3198 0.0242497783108494 1056 6470052
SGTC_793 0488-0545 106 µM -1.9783560651385 0.0648984799872819 no 3199 0.0239442762064426 1069 292548
SGTC_2736 butenafine 14.65 µM -1.98342938308821 0.0644220784774086 no 3200 0.0236597438662757 1062 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3069 9117009 49.47 µM -1.99633528354403 0.0632224189877837 no 3201 0.0229487199677 1064 41904981
SGTC_745 0469-0705 296 µM -1.99867753081489 0.0630065738692545 no 3202 0.0228216278262559 1068 3486736
SGTC_1797 st048695 56.8 µM -2.016155773425 0.0614139782832435 no 3203 0.0218918447295268 1053 592262 YIL048W NEO1
SGTC_3179 9107801 49.47 µM -2.01657148708369 0.0613764854178337 no 3204 0.0218701255211647 1061 4818259
SGTC_1361 1608-0041 5.61 µM -2.01819792516337 0.061229970139837 no 3205 0.0217853260798575 1070 X1361
SGTC_3094 9117742 49.47 µM -2.02169341929705 0.0609160086513709 no 3206 0.021604017071655 1064 17149698
SGTC_2861 9024595 19.48 µM -2.02823769021153 0.0603315949024116 no 3207 0.0212679974597948 1071 16482810
SGTC_1411 3909-8223 150 µM -2.03404204761978 0.0598169368351705 no 3208 0.0209736780920751 1078 X1411
SGTC_117 lucigenin 22.078 µM -2.04894744170934 0.0585110645715451 no 3209 0.0202336272867947 1064 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_261 5-fluorouridine 15.376 µM -2.05056781916263 0.0583704616756852 no 3210 0.0201545264825454 1072 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1920 st075728 45.7 µM -2.05232643946187 0.0582181636463309 no 3211 0.0200689740804857 1053 3400306
SGTC_1074 carmofur 3.8 µM -2.06134518475452 0.0574420325921793 no 3212 0.0196350601763052 1070 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_522 1273-0010 11.6 µM -2.06149657503854 0.0574290741254871 no 3213 0.0196278449423887 1058 5705015
SGTC_1642 st009582 77.7 µM -2.07888038019756 0.0559563159230688 no 3214 0.0188141732284315 1068 6739311
SGTC_2948 9070189 9.45 µM -2.07988247510717 0.0558723350277823 no 3215 0.0187681569118283 1040 6473636 YDL196W YDL196W
SGTC_963 1269-2853 151 µM -2.08168972647171 0.055721129138963 no 3216 0.0186854098168013 1067 3668223
SGTC_2919 7978188 46.38 µM -2.08192434121181 0.0557015235148691 no 3217 0.0186746905155002 1068 2980291
SGTC_2771 fluoxetine 41.05 µM -2.08287283259895 0.0556223181436533 no 3218 0.0186314082766205 1077 3386 A selective serotonin reuptake inhibitor.
SGTC_2847 9005661 71.43 µM -2.08461811070836 0.0554768080569942 no 3219 0.0185519896055534 1069 2991449
SGTC_192 3455-0609 60.9 µM -2.08465688181527 0.0554735789864918 no 3220 0.0185502286087337 1073 3769639
SGTC_2921 7974240 10.71 µM -2.09380052590516 0.0547161811980869 no 3221 0.0181388766554938 1060 2979074 YDR527W RBA50
SGTC_497 capsazepine 133 µM -2.09496448200777 0.0546203563372046 no 3222 0.0180870749778044 1067 2733484 A calcium channel blocker.
SGTC_1523 st012844 44.7 µM -2.11985130197522 0.0526030816070721 no 3223 0.017009293652811 1064 4274103
SGTC_149 3970-0822 46.1 µM -2.1296458437879 0.0518255568670253 no 3224 0.0166004316009119 1051 3114250 YBL034C STU1
SGTC_878 0828-0289 13.7 µM -2.1328592207385 0.0515724670619215 no 3225 0.016468138227093 1066 745350 YLR208W SEC13
SGTC_1506 4226-2149 212 µM -2.13462049863599 0.0514341640060009 no 3226 0.0163960108318208 1076 991114
SGTC_564 3555-0129 330 µM -2.15101551226368 0.0501608658177971 no 3227 0.0157374876594002 1060 563260
SGTC_2641 levomentholum 100 µM -2.16763250611681 0.0488960972957878 no 3228 0.0150933292365587 1074 16666
SGTC_1764 st044502 93.5 µM -2.16889374420561 0.048801150676746 no 3229 0.0150453759015929 1065 8407
SGTC_3058 9093861 49.47 µM -2.17097456715048 0.0486448274441321 no 3230 0.0149665474685739 1062 17217477
SGTC_1015 4130-4525 82 µM -2.17234501047499 0.0485420907842854 no 3231 0.0149148246939525 1070 1363237
SGTC_3284 9108171 64.8615 µM -2.17302164410856 0.0484914302780837 no 3232 0.0148893441524585 1058 8687505
SGTC_135 0933-0004 26.348 µM -2.17425280276603 0.0483993601646664 no 3233 0.0148430774138016 1048 21230617 YGL099W LSG1
SGTC_56 0957-0365 83.25 µM -2.17727658857323 0.0481738247954694 no 3234 0.014729968432788 1075 6752360
SGTC_636 0kpi-0074 126 µM -2.17949864882355 0.0480086244367135 no 3235 0.0146473224668684 1072 616434
SGTC_618 k072-0232 33.2 µM -2.18854601450405 0.0473406690325311 no 3236 0.0143149266556532 1046 5872756 YGL099W LSG1
SGTC_1403 3909-7815 62.9 µM -2.19230486345936 0.0470653570113969 no 3237 0.0141787504112601 1081 6615483
SGTC_1138 3761-0006 1.03 µM -2.19248337907921 0.0470523138644219 no 3238 0.0141723109712337 1077 12061087
SGTC_2973 9094665 17.96 µM -2.20319503672472 0.0462749621718284 no 3239 0.0137905024939255 1065 25237061 YIL048W NEO1
SGTC_1855 st056195 39.6 µM -2.20671487130373 0.0460217883329582 no 3240 0.013666992810832 1049 4028379
SGTC_1450 4112-4260 37.6 µM -2.21395665622797 0.0455044029497509 no 3241 0.0134158803588879 1072 1633175
SGTC_758 0868-0029 16 µM -2.2181689421147 0.0452056165258187 no 3242 0.0132716577590049 1059 762687
SGTC_2839 9003951 25.97 µM -2.21832475001085 0.0451945950846428 no 3243 0.0132663489062979 1061 2990634
SGTC_1476 4112-3294 3.34 µM -2.23171365371426 0.0442555458381602 no 3244 0.0128169471301466 1033 704369
SGTC_2068 5226020 147 µM -2.23514281463399 0.0440175839339721 no 3245 0.0127039871652843 1077 1810509
SGTC_2745 rifampicin 24.3 µM -2.23691937934277 0.0438947080190059 no 3246 0.012645804858631 1088 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_87 0100-0052 35.5 µM -2.2432738192117 0.0434574667286561 no 3247 0.0124395812870112 1084 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_519 k048-0011 62.8 µM -2.25196924268288 0.0428648498068687 no 3248 0.012162107883083 1067 6836379
SGTC_985 1493-0307 8.71 µM -2.25359112055441 0.0427550404215181 no 3249 0.0121109512288261 1075 3278274
SGTC_2725 haloperidol 53.21 µM -2.26415118626437 0.042045619031171 no 3250 0.0117824088408239 1068 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2199 6590217 200 µM -2.27239423374542 0.0414985009527864 no 3251 0.0115313548414256 1060 703109
SGTC_3215 9129942 49.47 µM -2.28886409235675 0.0404226220206348 no 3252 0.0110436250732923 1072 17682944
SGTC_891 0929-0073 133 µM -2.29457307969367 0.0400550159622812 no 3253 0.0108788012542328 1084 5603632
SGTC_2757 clomiphene 4.22 µM -2.29481076558625 0.0400397702811726 no 3254 0.0108719857095242 1077 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_85 0868-0259 160.055 µM -2.2979790251989 0.0398370013018431 no 3255 0.0107814914702409 1064 83173
SGTC_2774 tamoxifen 10.92 µM -2.2988861642827 0.0397790982584957 no 3256 0.010755702130954 1069 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_780 0109-0199 192 µM -2.31301115378312 0.0388862901064806 no 3257 0.010361012954174 1074 610414
SGTC_2837 9008476 45.46 µM -2.31367319900929 0.038844847401539 no 3258 0.0103428275481645 1068 2992805
SGTC_2381 9035592 200 µM -2.31550012414005 0.0387306721185785 no 3259 0.0102927888863964 1079 4749657
SGTC_2664 lyso-paf C-16 73.48 µM -2.32246632778646 0.0382978193652364 no 3260 0.0101039197449197 1080 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_676 falcarinol 140 µM -2.32930914817522 0.0378764813372428 no 3261 0.00992134704516055 1067 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_395 anisomycin 6.25 µM -2.33432110268706 0.0375702826267552 no 3262 0.0097894572799435 1085 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1906 st060206 94.7 µM -2.33866828253347 0.0373063370156944 no 3263 0.00967630394374237 1064 5133468
SGTC_400 oxethazaine 37.5 µM -2.33884417211494 0.0372956895808237 no 3264 0.00967174984546762 1078 4621 A local anesthetic.
SGTC_2034 5197015 53.07 µM -2.33979719561224 0.037238041685146 no 3265 0.0096471069026379 1081 780676
SGTC_2211 7117706 200 µM -2.36250643754276 0.0358857722078499 no 3266 0.00907591308966889 1081 822771
SGTC_1733 st037357 54.9 µM -2.37993920017505 0.0348752228264556 no 3267 0.00865774737665472 1070 1272339 YGL099W LSG1
SGTC_890 0929-0006 47.2 µM -2.38375787989988 0.034657008410567 no 3268 0.00856843651670557 1090 1378169
SGTC_989 1501-0895 10.3 µM -2.39140176011296 0.0342235755505666 no 3269 0.00839208754133837 1078 2830112
SGTC_2976 9009005 19.48 µM -2.40502815297098 0.0334619701784139 no 3270 0.00808560996887378 1065 2993148
SGTC_2982 9019404 25.97 µM -2.41961094231033 0.032662423421469 no 3271 0.00776856022941585 1064 22333232
SGTC_1392 3455-1037 33.9 µM -2.42056891660888 0.0326104557246375 no 3272 0.00774812081801361 1076 981132
SGTC_2663 amphotericin b 100 µM -2.46640011330507 0.0302027713785636 no 3273 0.00682393938145811 1083 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2902 5787006 60.46 µM -2.4702285998213 0.0300084955126914 no 3274 0.00675133672335676 1070 591003
SGTC_1728 st035614 33.7865 µM -2.47596934534788 0.0297191252117886 no 3275 0.00664374931784961 1078 15945546
SGTC_1508 1080-0625 72.9 µM -2.49120001667147 0.0289626045403574 no 3276 0.00636562129843259 1056 767111
SGTC_2980 9014342 25.29 µM -2.49835014441882 0.0286130110254715 no 3277 0.0062386441996529 1049 2996599
SGTC_394 menadione 8.33 µM -2.50642423244961 0.02822246852879 no 3278 0.00609795965055458 1073 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1061 3448-9325 110 µM -2.50953231424818 0.0280733185971991 no 3279 0.00604455770835408 1077 723482
SGTC_62 0180-0423 3.232 µM -2.51154216293148 0.0279772203136653 no 3280 0.00601024628083775 1084 30102 YGL099W LSG1
SGTC_1883 5-benzylidenerhodanine 20 µM -2.51236553853727 0.0279379308747801 no 3281 0.00599623982961112 1072 1273210
SGTC_1160 4092-0570 10.5 µM -2.51290356519828 0.0279122824138917 no 3282 0.00598710309141931 1085 4994975
SGTC_2636 apigenin dimethyl ether 100 µM -2.52324605743574 0.0274230419054331 no 3283 0.00581385042302333 1077 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1172 0370-0043 85 µM -2.54008430250155 0.0266418346583134 no 3284 0.00554128759555536 1090 376585
SGTC_2716 st080858 38.6235 µM -2.5401214207341 0.0266401333176753 no 3285 0.00554069951510161 1079 5296050
SGTC_2978 9011784 42.97 µM -2.54298185119086 0.0265092961564387 no 3286 0.00549554689222191 1059 2994934
SGTC_383 2324-0395 7.37 µM -2.55087812073192 0.0261509019492499 no 3287 0.00537259474144899 1039 3146421
SGTC_55 0767-0285 6.563 µM -2.55563708353933 0.0259368664911578 no 3288 0.00529968009652841 1077 3116166
SGTC_3126 9127922 49.47 µM -2.55951741756117 0.0257634340410649 no 3289 0.00524088016067656 1062 45595682
SGTC_2446 5162541 200 µM -2.5793583779882 0.0248917376695431 no 3290 0.00494920183109786 1083 1549321
SGTC_2913 7966556 36.57 µM -2.58215652491549 0.0247708165822414 no 3291 0.00490925211893879 1055 2976516
SGTC_2263 7948595 193.29 µM -2.58597724598035 0.0246065013312467 no 3292 0.00485516702986311 1085 2971371
SGTC_2717 st081029 62.2815 µM -2.59498368884465 0.0242227833745936 no 3293 0.00472977040467399 1088 5292846
SGTC_695 3505-6186 243 µM -2.59875296526849 0.024063692314438 no 3294 0.00467815394307163 1076 1819379
SGTC_2643 anethole 100 µM -2.60263965767409 0.0239005656938525 no 3295 0.00462545643148666 1092 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1024 4507-0395 26 µM -2.6047062804738 0.0238142075431628 no 3296 0.00459765250958148 1086 4201836
SGTC_3060 1327-0027 12.5 µM -2.61605933175158 0.0233444620161623 no 3297 0.0044475549746679 1078 16000455 YPR107C YTH1
SGTC_773 4358-1457 44.6 µM -2.62402599477403 0.0230195085047814 no 3298 0.00434485763745461 1092 1186886
SGTC_706 4262-0057 46.9 µM -2.66722410452287 0.0213231105103822 no 3299 0.00382403273310006 1089 883298
SGTC_1643 st009866 20.2 µM -2.67423484526815 0.0210580219212613 no 3300 0.00374499900443214 1073 3156273 YOR207C RET1
SGTC_3049 9092223 49.47 µM -2.6880547106375 0.0205436289244747 no 3301 0.00359348100762482 1085 8623917
SGTC_89 0302-0250 142.109 µM -2.698713540198 0.020154201334285 no 3302 0.00348040322272738 1092 4203518 YLR208W SEC13
SGTC_2561 acetosyringone 100 µM -2.7295622556311 0.0190622264451035 no 3303 0.00317092367417301 1082 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2283 7944793 200 µM -2.73201454611222 0.0189776215975828 no 3304 0.00314741808578377 1073 2970533
SGTC_2183 6420625 130.508 µM -2.73743931941655 0.0187915991803926 no 3305 0.00309597710724108 1082 2897619
SGTC_1886 st057356 49.9 µM -2.73867522662926 0.0187494360315896 no 3306 0.00308436389275359 1089 24207747
SGTC_765 1319-0117 244 µM -2.75409235872241 0.0182302086382389 no 3307 0.0029427578384978 1079 3487746 YGL099W LSG1
SGTC_799 1310-0557 151 µM -2.75413432778076 0.0182288120742551 no 3308 0.00294238048619803 1088 5354492
SGTC_3071 9117417 49.47 µM -2.75507982659917 0.0181973737731874 no 3309 0.00293389086590125 1082 45595590 YGL055W OLE1
SGTC_2274 7947094 46.08 µM -2.76282885969234 0.0179414515032819 no 3310 0.00286514017211304 1086 2971028
SGTC_2866 9034245 58.44 µM -2.77017015106551 0.0177018330898033 no 3311 0.00280135079370896 1090 6462273
SGTC_705 1124-0212 310 µM -2.77290740092548 0.0176131913370681 no 3312 0.00277789637393031 1086 9554485
SGTC_1534 6-azauridine 81.6 µM -2.77455057302791 0.0175601618444001 no 3313 0.00276390193775362 1088 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1326 1431-2094 10.8 µM -2.77710916301442 0.0174778607520755 no 3314 0.00274223778025274 1085 616278
SGTC_1039 k821-0043 94 µM -2.82254141061157 0.0160703960563358 no 3315 0.00238223342589829 1085 15992768
SGTC_3026 9090633 49.47 µM -2.83993277994739 0.015557933414914 no 3316 0.0022561520569578 1086 25236842
SGTC_1159 4092-0538 61.2 µM -2.85399864108067 0.0151537813570148 no 3317 0.00215863579976682 1090 717301
SGTC_398 bronopol 33.3 µM -2.87399162286374 0.0145948671888572 no 3318 0.00202659856816806 1086 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_775 4577-0580 57.3 µM -2.87526180074696 0.0145599659278148 no 3319 0.00201846308750993 1089 2006902
SGTC_2625 euphol 100 µM -2.88281936484638 0.014353784903346 no 3320 0.0019706669092915 1087 6708538 A triterpene alcohol.
SGTC_3096 9117468 49.47 µM -2.92423405204075 0.0132680162144811 no 3321 0.00172652501946779 1089 41316311
SGTC_2860 9025725 38.96 µM -2.93007071328212 0.0131208500817676 no 3322 0.00169442438225396 1092 40546248
SGTC_879 0831-1030 162 µM -2.95618318747257 0.0124795941845305 no 3323 0.00155736018242177 1091 1549252
SGTC_889 0919-1524 82.7 µM -2.96768140720284 0.012205946136335 no 3324 0.00150027581436395 1094 3905452
SGTC_2967 9089538 49.85 µM -2.97633921426487 0.0120033439505805 no 3325 0.00145856001118076 1090 728216
SGTC_1069 diphenylcyclopropenone 8.49 µM -2.98079069790156 0.0119003141870401 no 3326 0.0014375260971591 1093 65057 A dermal irritant. YDR527W RBA50
SGTC_790 1575-0012 79.1 µM -2.99356600329933 0.0116088781240193 no 3327 0.00137868930253841 1084 378741 YLR208W SEC13
SGTC_2758 dehydroepiandrosterone 69.35 µM -3.03442930609389 0.0107179055009187 no 3328 0.00120495613892684 1090 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_171 k064-0041 9.68 µM -3.1174159253544 0.00909004939006801 no 3329 0.000912219881429441 1083 53325
SGTC_2208 7283366 200 µM -3.13134120539747 0.00883923361163441 no 3330 0.000870049305581715 1093 898663
SGTC_786 4544-0069 423 µM -3.21447161110193 0.00746439476678451 no 3331 0.000653424183506359 1092 748821 YLR208W SEC13
SGTC_3108 9121785 49.47 µM -3.26803722863673 0.00668171237992964 no 3332 0.0005414805975929 1066 17140271
SGTC_3052 9092717 49.47 µM -3.2993134168312 0.0062590592373676 no 3333 0.000484608169965069 1088 25237534
SGTC_595 3909-8003 73.7 µM -3.35489020766968 0.00556612394522147 no 3334 0.000396982446773743 1094 699517
SGTC_1420 4'-methoxyflavone 42 µM -3.42972346241272 0.00474101670979853 no 3335 0.000302098343840923 1093 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_960 1222-0186 7.7 µM -3.44873217349878 0.00454962465399464 no 3336 0.000281612520088177 1094 3126296
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -3.45955084739364 0.00444380264045274 no 3337 0.000270538553822483 1091 521171
SGTC_177 1327-0068 8.361 µM -3.47839891058135 0.00426468340537504 no 3338 0.000252209327281162 1087 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_696 1560-0013 611 µM -3.59400982754855 0.00330046688862001 no 3339 0.000162813773050963 1092 1650269
SGTC_953 1188-0045 9.7 µM -3.64509037746214 0.00294072763597959 no 3340 0.000133648924916273 1090 6144426
SGTC_876 0720-0963 56.8 µM -3.72020060948312 0.00247575456200059 no 3341 9.95322976050933e-05 1095 765861
SGTC_3056 9094900 49.47 µM -3.72454824566296 0.00245099654596534 no 3342 9.78326456940525e-05 1092 25236784
SGTC_2412 st077135 33.4 µM -3.75270909856973 0.0022959825769952 no 3343 8.74669055914015e-05 1092 13258915
SGTC_2851 9015922 71.43 µM -3.77700554640331 0.00216943553623971 no 3344 7.93625991142561e-05 1093 2996893
SGTC_3157 9099274 49.47 µM -3.78532999615057 0.00212755439098219 no 3345 7.6752372040158e-05 1091 17217662
SGTC_710 3448-4187 58 µM -3.79030649020376 0.00210286871382958 no 3346 7.52307564858857e-05 1095 3946412
SGTC_2302 7771753 200 µM -3.83008333641115 0.00191470579753578 no 3347 6.40499342523391e-05 1087 2203047
SGTC_2015 5119600 184 µM -3.91407162816161 0.00156670428340972 no 3348 4.53763475253978e-05 1092 2828786
SGTC_159 3970-0959 50 µM -4.10471919525042 0.000980398285732994 yes 3349 2.02403143621788e-05 1089 6615653
SGTC_711 k292-0785 179 µM -4.38961463178612 0.000469890254728005 yes 3350 5.67758544774208e-06 1092 4146315
SGTC_517 1365-0151 113 µM -4.55873821774735 0.000297674990974948 yes 3351 2.57309348306064e-06 1095 768657
SGTC_2939 9044578 71.43 µM -4.66262934932783 0.000223229456546509 yes 3352 1.56097368751194e-06 1095 2653634
SGTC_2017 5132927 60.65 µM -4.81375303873008 0.000145401507566231 yes 3353 7.40609195366262e-07 1094 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_175 3793-3120 23.7 µM -4.96606287203143 9.32558388366031e-05 yes 3354 3.41629059465134e-07 1092 5322297
SGTC_961 1252-1571 372 µM -4.98169029037486 8.90401891258302e-05 yes 3355 3.15156296015456e-07 1095 6813498
SGTC_2835 9006588 71.43 µM -5.18327211166762 4.84673348631608e-05 yes 3356 1.09013291720801e-07 1093 2345538