SGTCid condition conc unit MRP2|YPR166C.score MRP2|YPR166C.strain.pval MRP2|YPR166C.strain.significant MRP2|YPR166C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_236 1509-0011 5.31 µM 20.7498572616522 4.37214903463432e-77 yes 1 6.14779570611253e-96 49 3107280 SGTC_275 trichlorophene 5.69 µM 15.9218993066485 2.95382690260314e-46 yes 2 2.23305593959569e-57 7 62616 SGTC_70 0141-0289 43.283 µM 9.74999147343848 1.46840951957682e-18 yes 3 9.2241882408145e-23 19 352408 SGTC_908 3448-7491 47.7 µM 9.09575635241791 2.16299302007189e-16 yes 4 4.69651903015356e-20 12 1203031 SGTC_386 1509-0011 3.07 µM 8.26812871110902 7.38114184256175e-14 yes 5 6.80389702396831e-17 59 3107280 SGTC_173 1273-0061 2.693 µM 8.17862930985524 1.34286237269547e-13 yes 6 1.43545402533614e-16 62 2847414 YPL266W DIM1 SGTC_1882 5615643 20 µM 7.43761686224989 1.4964660835308e-11 yes 7 5.12589404542082e-14 11 2253075 SGTC_1883 5-benzylidenerhodanine 20 µM 7.39158050358701 1.97730930905108e-11 yes 8 7.25468364588534e-14 13 1273210 SGTC_2598 perillyl alcohol 100 µM 5.75516244870313 1.35169202247269e-07 yes 9 4.32792582926088e-09 7 10819 An apoptosis inducer. SGTC_2183 6420625 130.508 µM 5.74035113164608 1.45030100772541e-07 yes 10 4.72402222851792e-09 16 2897619 SGTC_2232 chlorophetanol 41.5365 µM 5.3781161318582 7.69881509193668e-07 yes 11 3.76346309301549e-08 59 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_310 1273-0058 1.06 µM 5.08573253931821 2.75128470476226e-06 yes 12 1.83104913872259e-07 180 2734232 SGTC_1742 st038235 28.8875 µM 4.96217641023082 4.62050158726007e-06 yes 13 3.48538192602474e-07 77 564103 YBR002C RER2 SGTC_1906 st060206 94.7 µM 4.92878107051415 5.30482566833555e-06 yes 14 4.1372115694963e-07 9 5133468 SGTC_748 act1.228 77.9 µM 4.81802138437716 8.33586502370284e-06 yes 15 7.24944172717098e-07 49 4421505 YNR035C ARC35 SGTC_3239 9133757 49.47 µM 4.77602495605989 9.86975539982312e-06 yes 16 8.93971068327146e-07 1 17036923 SGTC_1188 1403-0014 4.57 µM 4.7547543788428 1.07457402729696e-05 yes 17 9.93439134961711e-07 32 9614867 SGTC_966 1300-0360 30.2 µM 4.57112525563388 2.20702651948052e-05 yes 18 2.42556097161272e-06 14 70588 SGTC_1635 st007035 42.4 µM 4.55814374633718 2.31996445083921e-05 yes 19 2.58038562679649e-06 181 3716403 SGTC_119 0121-0043 24.815 µM 4.54681898241493 2.42294432730945e-05 yes 20 2.72314006901826e-06 74 1092378 SGTC_1921 5740136 50 µM 4.19095365832917 9.02533504337484e-05 yes 21 1.38892199157153e-05 48 1774243 SGTC_134 0269-0018 6.916 µM 4.18258165137492 9.29814905051336e-05 yes 22 1.44108727162356e-05 124 4378915 SGTC_1621 st003705 32.4 µM 4.13817431053397 0.000108795751659057 yes 23 1.75040184562025e-05 21 24207032 SGTC_503 tyrphostin 8 294 µM 4.13673426388826 0.000109348587963342 yes 24 1.76141840832753e-05 18 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_10 0279-0212 42.575 µM 4.02581859140746 0.000160809195944116 yes 25 2.83887248013286e-05 115 39851 YBR002C RER2 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 3.95635257697747 0.000203778483120914 yes 26 3.80514081801181e-05 31 23665772 A membrane-active detergent. SGTC_1889 st059080 5.18 µM 3.95601104308626 0.000204014048668303 yes 27 3.81058197316819e-05 15 176925 Isolated from Daphnopsis sellowiana. SGTC_1623 st003709 20.3 µM 3.93478029213549 0.000219167069997498 yes 28 4.16364184034168e-05 72 16192618 SGTC_2419 paclitaxel 166.5 µM 3.82867601399102 0.000311938373699803 yes 29 6.44172374689186e-05 45 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_767 0929-0023 86 µM 3.73341145864326 0.000425176224618069 yes 30 9.44518098990113e-05 88 1204563 SGTC_462 ag-879 158 µM 3.71215085647118 0.000455178873357734 yes 31 0.000102752717333702 38 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_314 1671-0008 2.74 µM 3.65114196769134 0.000552512559929831 yes 32 0.000130538433240909 67 3913060 SGTC_1922 5578187 25 µM 3.64854682766894 0.000557051346948137 yes 33 0.000131863918483724 42 1350412 SGTC_168 3970-0862 530.542 µM 3.60607496500568 0.000636404864539714 yes 34 0.00015543168338022 142 3135186 SGTC_1247 0448-0043 5.84 µM 3.59453069581235 0.00065971021135432 yes 35 0.000162488415517474 65 3089013 YGL099W LSG1 SGTC_1703 st026983 48.3 µM 3.55412826414613 0.000747615300068424 yes 36 0.00018961710547837 17 1104023 SGTC_920 mycophenolic acid 780.421 nM 3.49727772455996 0.000889657321598175 yes 37 0.000235016112488081 48 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1881 5652484 16 µM 3.3997730936863 0.00119221260423483 no 38 0.000337208971863863 46 2255129 SGTC_520 3584-0023 682 µM 3.29690387328373 0.00161120724666203 no 39 0.000488784764241967 52 1340790 SGTC_1563 conessine 56.1 µM 3.2659729875743 0.00176121856952167 no 40 0.000545443274999757 36 441082 An anti-amoebic, histamine inhibitor. SGTC_2010 4012422 159 µM 3.26286825871618 0.00177695730721215 no 41 0.00055145388360629 51 952393 SGTC_1622 st003707 19.4 µM 3.26243491306435 0.00177916420426231 no 42 0.00055229767459268 70 10140899 SGTC_2231 micatex 6.853 µM 3.26063527334745 0.00178835592392785 no 43 0.000555814641527143 33 20737 An antifungal of unknown mechanism. SGTC_2408 sulbentine 18.36 µM 3.25620394154825 0.00181117352207235 no 44 0.000564563083429751 78 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3258 9138477 49.47 µM 3.25307262260369 0.00182745646588079 no 45 0.0005708215787691 18 4970355 SGTC_3211 9128781 49.47 µM 3.24942449330929 0.00184659464910351 no 46 0.000578193865800027 104 17194361 SGTC_1333 1482-0047 286 µM 3.23922688418808 0.00190106208887806 no 47 0.000599270956991655 40 3811116 SGTC_1722 st034304 3.6505 µM 3.23314880166962 0.00193421668812667 no 48 0.000612168859745601 62 4036148 YLR033W RSC58 SGTC_2180 6301957 200 µM 3.20542871801947 0.00209218405044824 no 49 0.000674307228192397 19 845462 SGTC_474 dl-dihydrosphingosine 5 µM 3.18826151902819 0.00219579240194465 no 50 0.000715655107337887 69 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2622 2-methoxyxanthone 59.94 µM 3.14976116106025 0.00244525617282275 no 51 0.000817019941650745 40 71034 A hepatoprotective. SGTC_1318 1280-3875 124 µM 3.13886621513595 0.00252036129066432 no 52 0.000848014306772354 65 373245 SGTC_63 0099-0242 26.702 µM 3.1019719025003 0.00279043663830224 no 53 0.000961181017832099 143 3898502 YLR359W ADE13 SGTC_2343 7990716 14.84 µM 3.08189881249031 0.00294810027911137 no 54 0.00102842371606406 48 6456862 SGTC_365 0121-0052 13.6 µM 3.08125232361675 0.002953308997912 no 55 0.0010306594367077 119 3101739 SGTC_2250 alverine citrate 130 µM 3.06438610250253 0.00309216349589021 no 56 0.00109058605109072 249 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2832 7992762 51.95 µM 3.05749900739264 0.00315053339904866 no 57 0.00111596190302483 67 2985177 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 3.04140368904898 0.00329083048678694 no 58 0.00117738942689128 42 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2944 9067346 25.62 µM 3.04074096294278 0.00329672582921247 no 59 0.00117998384683651 76 6473075 SGTC_3228 9131799 49.47 µM 3.04020609256774 0.0033014907425095 no 60 0.00118208155701047 27 17015818 SGTC_735 3076-0345 636 µM 3.03812766927532 0.00332006529838478 no 61 0.00119026538603521 79 2888990 SGTC_1336 1486-0901 104 µM 3.03533885880848 0.00334513608473999 no 62 0.00120132787597131 52 5006114 SGTC_127 0180-0333 59.125 µM 3.02338089613515 0.00345457581092447 no 63 0.00124983701526698 106 771601 SGTC_1565 sinapyl alcohol 95.1 µM 3.00660567793813 0.00361352459354922 no 64 0.00132091104685715 82 5280507 A phenol propionate derived from cinnamic acid. SGTC_903 1134-0042 114 µM 2.98328761791582 0.00384536936860058 no 65 0.00142584936678523 66 701009 SGTC_2113 5491891 107.031 µM 2.97572432301631 0.00392338290641574 no 66 0.00146148743989894 77 789979 SGTC_2499 avocadenofuran 51.48 µM 2.97281463297347 0.00395377131079056 no 67 0.0014754130083985 93 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_120 rhodamine 6G 52.259 µM 2.96695930814964 0.00401556326179295 no 68 0.00150380380648932 97 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1240 0356-0016 42.1 µM 2.95938753526958 0.00409675052274895 no 69 0.00154125595978773 76 4305613 SGTC_1063 disulfiram 1.84 µM 2.91933805731951 0.00455110100565942 no 70 0.00175387798264282 76 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2087 5276107 200 µM 2.90808657304239 0.00468659280433232 no 71 0.00181823825668425 72 144405 SGTC_2005 4024620 188 µM 2.88838071364436 0.00493258447503917 no 72 0.0019361543580235 75 236743 SGTC_799 1310-0557 151 µM 2.88106486337242 0.00502679757690983 no 73 0.00198167034173462 88 5354492 SGTC_283 0987-0079 11.7 µM 2.88079046822727 0.00503036219524896 no 74 0.00198339625887539 90 411556 SGTC_1723 st034307 2.5525 µM 2.86080303058007 0.00529614731980497 no 75 0.00211284749436973 82 867466 SGTC_3309 9129340 25.759 µM 2.82304640475893 0.00583249790132936 no 76 0.00237848428898128 62 17158987 SGTC_741 4582-0002 126 µM 2.81194914666036 0.0059990465547348 no 77 0.00246211439279612 72 2912688 SGTC_760 0568-0725 82.9 µM 2.80410869881701 0.00611924491991151 no 78 0.00252279457279404 50 3916171 SGTC_2057 5236571 38.335 µM 2.8025143877811 0.00614394603251315 no 79 0.00253529773211785 109 54684039 YBR257W POP4 SGTC_1274 0865-0114 173 µM 2.79330040627391 0.00628843879856341 no 80 0.00260866075683112 76 870624 SGTC_2181 6316240 54.2555 µM 2.78437325500394 0.00643129486897828 no 81 0.00268156385627722 74 12779990 SGTC_721 1187-1332 279 µM 2.77199332007433 0.0066341538295143 no 82 0.00278570899275882 55 25730 SGTC_2299 7976368 114.88 µM 2.726099920118 0.0074363753470046 no 83 0.00320437970640757 84 2979718 SGTC_2484 5809818 12.04 µM 2.72432491256577 0.00746905041495428 no 84 0.0032216541975008 70 2870548 SGTC_1068 loratadine 26.9 µM 2.71913027647469 0.00756540328371077 no 85 0.00327269115224721 92 3957 A H1 histamine antagonist. SGTC_877 0771-0151 33.1 µM 2.69046534192043 0.00811703197698628 no 86 0.00356762230593801 79 6166523 SGTC_260 nsc-65238 3.989 µM 2.67297483492421 0.0084707177158966 no 87 0.00375909450534686 71 3246252 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.6655613658991 0.00862466549431345 no 88 0.00384299513851645 101 688761 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.65739208690983 0.00879714543446199 no 89 0.00393738985795038 95 94937 An inhibitor of serotonin biosynthesis. SGTC_761 k216-0224 480 µM 2.63950716312053 0.00918534371271979 no 90 0.0041513334313504 102 1340404 SGTC_2624 nerol 100 µM 2.59791738618074 0.0101465223234335 no 91 0.00468955280812979 77 637566 A natural product oil. SGTC_1319 1306-0155 43.7 µM 2.58613622286892 0.0104342716699889 no 92 0.00485292815019478 135 3122360 SGTC_1529 apigenin 74 µM 2.57974230205278 0.0105933979491933 no 93 0.00494370338069436 136 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_539 4859-0462 2.54 µM 2.57549201070218 0.0107003414497208 no 94 0.00500487928707276 109 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_832 4083-0019 164 µM 2.56202627546693 0.0110453903141451 no 95 0.00520317226109994 267 1990758 SGTC_1854 st056233 32.9 µM 2.55568830257515 0.0112111184465424 no 96 0.00529890015254398 97 5393174 SGTC_1332 1480-0653 17.5 µM 2.55442778049576 0.0112443356419119 no 97 0.00531812459084464 110 5749438 SGTC_2943 9068529 45.32 µM 2.55383813607845 0.011259903260516 no 98 0.00532713863330903 121 3270634 SGTC_3229 9132204 49.47 µM 2.55094205833987 0.0113366369271838 no 99 0.00537160923730027 50 17682924 SGTC_1640 st009078 66.4 µM 2.54863585127289 0.0113980661650447 no 100 0.00540725785317101 80 690618 SGTC_852 0418-0143 439 µM 2.53153360969571 0.0118627011226202 no 101 0.00567824665807487 184 5369229 SGTC_2556 citropten 84.59 µM 2.51531623274597 0.0123183863050844 no 102 0.00594628290411735 148 2775 A potential DNA crosslinker. SGTC_2287 7945887 168.79 µM 2.49651458632317 0.0128655973795121 no 103 0.00627102552394214 85 1245853 SGTC_1289 0976-0073 69.1 µM 2.49120589268738 0.0130238602453731 no 104 0.00636551601567807 95 3391136 SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.48868987417176 0.013099453827963 no 105 0.006410737648933 175 140250 A respiratory chain inhibitor. SGTC_2878 9043973 25.97 µM 2.48782946519468 0.0131253916193006 no 106 0.00642626730306573 90 6465167 SGTC_831 k061-1017 217 µM 2.4809719237922 0.0133337094844792 no 107 0.00655123464720039 222 1240153 SGTC_1134 3477-0009 42.5 µM 2.47943669713195 0.0133807357511656 no 108 0.00657950429102001 160 3973534 SGTC_1486 3970-0793 4.53 µM 2.47414628106701 0.0135438878600922 no 109 0.00667775000118022 73 2844330 SGTC_3243 9134147 49.47 µM 2.46592296155691 0.0138008966880513 no 110 0.00683303615433092 48 24282180 SGTC_2016 5121758 140 µM 2.46214487543512 0.013920379009825 no 111 0.00690544335496274 175 2795203 SGTC_2750 bromebric acid 70.15 µM 2.45539622699469 0.0141360258639304 no 112 0.00703646889451219 149 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2058 5236698 133 µM 2.44656397372258 0.0144225966156785 no 113 0.00721125997951557 135 766665 SGTC_218 alverine citrate 93.75 µM 2.43031762030368 0.0149627998108505 no 114 0.00754279811995258 114 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1284 0929-0043 16 µM 2.42317493097236 0.0152057498425955 no 115 0.0076927579949131 120 1239883 SGTC_2698 st077697 67.5 µM 2.42130362841813 0.0152699573934186 no 116 0.00773247703346904 106 3154499 SGTC_596 1155-0152 116 µM 2.41438628571049 0.0155093284583573 no 117 0.00788087104601807 176 280313 SGTC_1483 3453-0561 55.9 µM 2.40728757717012 0.0157583170282896 no 118 0.00803575441357856 128 4546991 SGTC_1967 st070177 51.4 µM 2.39723748598352 0.0161166844862755 no 119 0.00825960658753056 120 5729214 SGTC_2942 9052777 62.25 µM 2.39539857126756 0.0161830070270296 no 120 0.00830115348863246 157 6469503 SGTC_1641 st009299 47.1 µM 2.3910082677852 0.0163422944653877 no 121 0.00840108725136978 66 4046054 SGTC_2037 5169046 200 µM 2.39048833028014 0.0163612472789116 no 122 0.00841299192930928 105 5718022 SGTC_2806 7952793 58.44 µM 2.37771396191086 0.0168328471399363 no 123 0.00871016661933077 133 2972490 SGTC_1452 4194-0072 190 µM 2.36013986036121 0.0175006069403162 no 124 0.00913402316083537 139 1343545 SGTC_876 0720-0963 56.8 µM 2.36006977625992 0.0175033145436471 no 125 0.00913574899422615 120 765861 SGTC_1122 capsaicin 818.572 nM 2.35866099527563 0.0175578167648945 no 126 0.00917050107303042 143 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3165 9101544 49.47 µM 2.34144941672686 0.0182354713559665 no 127 0.00960451436618656 124 5002184 SGTC_2270 7924575 90.91 µM 2.33410006209589 0.0185315498380731 no 128 0.00979524152764633 138 1262135 SGTC_149 3970-0822 46.1 µM 2.33015804632275 0.0186920389398237 no 129 0.00989889971924486 286 3114250 YBL034C STU1 SGTC_3312 9133330 71.43 µM 2.32822754915208 0.0187710647504242 no 130 0.0099500120339038 109 17617324 SGTC_778 3456-2434 196 µM 2.32285809357795 0.0189923625510039 no 131 0.0100933885077107 219 5539063 SGTC_19 0279-0214 38.434 µM 2.30404338344009 0.0197853860950211 no 132 0.0106101041940561 239 3566274 YBR002C RER2 SGTC_1011 4112-3381 17.4 µM 2.29603296204852 0.0201314523838329 no 133 0.0108369983841426 168 2877139 SGTC_2826 7992541 19.48 µM 2.29389526578994 0.0202246682368447 no 134 0.0108982577133013 156 2985066 SGTC_261 5-fluorouridine 15.376 µM 2.29086604570076 0.0203573861953443 no 135 0.0109855811621266 158 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_745 0469-0705 296 µM 2.28143269638582 0.0207754236966431 no 136 0.0112614275523241 172 3486736 SGTC_398 bronopol 33.3 µM 2.2772630277573 0.0209625055610256 no 137 0.0113852616829546 157 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_87 0100-0052 35.5 µM 2.26949151985681 0.0213149985592105 no 138 0.0116192261686183 365 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1266 0828-0227 32.9 µM 2.2673617926783 0.0214124672727226 no 139 0.0116840667503195 151 3913820 SGTC_1036 k216-0215 33.5 µM 2.25888123721322 0.0218043326508465 no 140 0.0119453867090369 224 622330 SGTC_2601 securinine 100 µM 2.25818895602096 0.0218365869556982 no 141 0.0119669407513574 165 442872 A GABA receptor antagonist. SGTC_793 0488-0545 106 µM 2.25363224064603 0.0220498974750988 no 142 0.0121096566628144 167 292548 SGTC_1371 2421-0008 32.7 µM 2.24935340303643 0.0222517985676886 no 143 0.0122450103520575 203 2827552 SGTC_2996 9066192 71.4286 µM 2.24767482343062 0.0223314288471324 no 144 0.0122984662687027 199 6472854 SGTC_1125 tnp00248 1.32998 µM 2.2400491706049 0.022696215853265 no 145 0.0125438654329455 238 24207736 SGTC_2804 7954240 19.48 µM 2.23739986893292 0.0228241199522341 no 146 0.0126301085513928 181 828705 SGTC_530 4358-1714 28 µM 2.23646769985099 0.0228692678070274 no 147 0.0126605754088027 199 1564641 SGTC_2170 morpholine 200 µM 2.23273034907407 0.023051035626228 no 148 0.0127833659125734 130 121171 Reacts with secondary amines. SGTC_3134 9127454 49.47 µM 2.22280484696712 0.0235396821252217 no 149 0.013114481060174 123 24262820 SGTC_681 1642-0006 26.6 µM 2.2193042361944 0.0237140878079 no 150 0.0132330168069227 96 4446530 SGTC_1860 st056228 74.6 µM 2.19443423272563 0.0249846868255437 no 151 0.0141021035776119 161 688679 SGTC_2701 st077767 14.721 µM 2.17492016973699 0.0260211827247094 no 152 0.0148180495834724 223 5721188 SGTC_2094 5332512 191.667 µM 2.16968825415576 0.0263051139431233 no 153 0.0150152352336469 200 755774 SGTC_1368 1852-0141 284 µM 2.16625050197912 0.0264930839025093 no 154 0.0151460249449864 192 2838987 SGTC_526 4469-0568 170 µM 2.15352342858104 0.0271987726190682 no 155 0.0156387824212012 198 2901964 SGTC_456 gingerol 170 µM 2.13163849347642 0.0284488926305979 no 156 0.016518288360234 183 442793 A herb. SGTC_2824 7998404 51.95 µM 2.13076705989113 0.0284996446681517 no 157 0.016554168667322 172 837851 SGTC_757 1066-0008 322 µM 2.12942287312598 0.028578077396641 no 158 0.0166096448575342 185 6842497 SGTC_2900 5328528 85.29 µM 2.12548319845819 0.0288089906159565 no 159 0.0167731572798036 215 795359 SGTC_1455 4262-0120 131 µM 2.12405891651658 0.028892851838542 no 160 0.0168326086580155 208 1529587 SGTC_2897 9048598 12.99 µM 2.12072041541953 0.0290902170850545 no 161 0.0169726687220049 153 6467404 SGTC_1431 4049-0260 9.09 µM 2.09767181270143 0.0304835749091017 no 162 0.0179670732596541 173 3854841 SGTC_1935 st074532 41.6 µM 2.09318824934106 0.030760943902902 no 163 0.0181661766425127 239 2829742 SGTC_700 3453-2283 142 µM 2.08900537703884 0.0310215918998011 no 164 0.0183536195728692 229 565664 SGTC_869 0564-0080 44.1 µM 2.08143350513465 0.0314980669487789 no 165 0.0186971222830337 225 6843321 SGTC_2903 5923464 63.88 µM 2.08127784399335 0.0315079253440065 no 166 0.0187042409623695 144 2876576 SGTC_68 0986-0284 82.829 µM 2.07724853867194 0.0317639997642198 no 167 0.0188893130234846 268 423278 YIL048W NEO1 SGTC_3163 9099914 49.47 µM 2.07575548359168 0.0318593234510234 no 168 0.0189582857502709 98 16268368 SGTC_2099 5377090 177.372 µM 2.07536517505998 0.0318842815133833 no 169 0.0189763516050574 216 2243829 SGTC_2105 5350118 200 µM 2.07420466776961 0.031958584915882 no 170 0.0190301534589189 194 2133313 SGTC_279 1273-0055 2.93 µM 2.06429212661403 0.0325990966747714 no 171 0.0194950135383446 222 2847562 SGTC_704 1310-0270 142 µM 2.05733524396189 0.033054918125159 no 172 0.0198269947081985 242 5718033 SGTC_1956 st077085 54 µM 2.05701533419061 0.033076004581349 no 173 0.0198423754375785 222 24208685 SGTC_1021 4476-0760 85.3 µM 2.05321234568922 0.0333275239048788 no 174 0.0200259937926081 218 746768 SGTC_1212 0520-0165 585 µM 2.05107706659392 0.0334694345504519 no 175 0.0201297211372433 219 5403258 SGTC_1349 flufenamic acid 69 µM 2.04648985327972 0.0337759833911238 no 176 0.0203540998789012 189 3371 A non-steroidal anti-inflammatory. SGTC_1648 st011736 69.8 µM 2.03955638843066 0.0342437061102022 no 177 0.0206972647596589 184 2855514 SGTC_2560 caryophyllene 100 µM 2.02641104130121 0.0351450882817254 no 178 0.0213613402121761 235 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2603 homopterocarpin 100 µM 2.02392082058829 0.0353180180071079 no 179 0.0214891496476794 258 101795 A weak amylase inhibitor. SGTC_614 0462-0418 107 µM 2.02152355341145 0.0354851514095936 no 180 0.0216127983346989 225 5188303 SGTC_330 1488-0319 80.1 µM 2.02091170136124 0.0355279124170811 no 181 0.0216444531940738 190 6846614 SGTC_933 2914-0560 114 µM 2.01588973336855 0.0358804854771123 no 182 0.021905753706962 238 463887 SGTC_2294 7971431 200 µM 2.01392546242636 0.0360191669729479 no 183 0.0220086798917072 173 5741572 SGTC_825 1988-2224 89.6 µM 2.01205948212643 0.0361513152671463 no 184 0.0221068335690763 242 1180859 SGTC_2805 7950783 58.44 µM 2.00779932872097 0.0364545064794502 no 185 0.0223323101066759 248 1178958 YDL195W SEC31 SGTC_2507 purpurin 79.67 µM 2.00607460482588 0.0365778437837649 no 186 0.0224241444284794 255 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2233 sulbentine 40.3845 µM 2.00418865030331 0.0367131014452228 no 187 0.0225249279476774 283 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3135 9127742 49.47 µM 2.00347688742934 0.0367642541567724 no 188 0.0225630629845082 177 3643468 SGTC_1819 st053448 58.6 µM 2.00274494383414 0.0368169179835643 no 189 0.022602336026109 198 2857616 SGTC_1348 1493-0373 93.8 µM 2.00143950105548 0.036910998577646 no 190 0.0226725236924908 201 3010129 SGTC_823 0417-1665 178 µM 1.99823126677269 0.0371430447515678 no 191 0.0228457966203146 235 3429856 SGTC_341 1486-1430 230 µM 1.99383711216737 0.0374627997375993 no 192 0.0230849291851456 232 2054753 YPL210C SRP72 SGTC_3238 9133470 49.47 µM 1.98931128382283 0.0377944829430109 no 193 0.0233334274851203 176 3534688 SGTC_324 1315-0088 19.6 µM 1.98572246103285 0.038059196498333 no 194 0.0235320747880154 168 6787421 SGTC_81 0411-0046 9.971 µM 1.98087535518841 0.0384191204615081 no 195 0.0238026267380479 199 12925265 SGTC_2457 5731572 11.68 µM 1.97708160415077 0.0387027586527216 no 196 0.024016203398277 173 2865357 SGTC_2133 5320837 200 µM 1.97336311937049 0.03898242284204 no 197 0.0242271031681676 227 2841355 SGTC_675 1309-0189 238 µM 1.96621777482517 0.0395244366083875 no 198 0.0246367300503832 211 4246530 SGTC_118 0083-0097 135.343 µM 1.96125352856703 0.039904598668362 no 199 0.0249247276941375 492 5207356 SGTC_1550 gossypolone 36.6 µM 1.95884577693993 0.040090051745109 no 200 0.0250654253760828 246 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2041 5107442 45.335 µM 1.95809446695522 0.0401480632890869 no 201 0.0251094644486782 261 793005 SGTC_421 streptovitacin 30 mM 1.95616712783877 0.0402971924903793 no 202 0.0252227347557626 260 91467 include heat shock SGTC_2280 7785178 200 µM 1.95124285866938 0.0406802550596472 no 203 0.0255140814255295 199 2954328 SGTC_534 k292-0788 63.4 µM 1.94644745956633 0.041056127718792 no 204 0.0258005066878539 257 4146317 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.94473625674639 0.041190935024751 no 205 0.0259033647266122 193 97141 SGTC_3085 9117376 49.47 µM 1.94107342722379 0.041480696333514 no 206 0.0261246858351563 224 16480349 SGTC_2060 5238662 140 µM 1.93925579295494 0.0416250988070581 no 207 0.026235099463619 232 790130 SGTC_2930 9013230 14.89 µM 1.93392039945164 0.0420513239997246 no 208 0.0265614577845352 281 2995857 SGTC_2417 cerulenin 830 nM 1.9267596385937 0.0426289160520791 no 209 0.0270047958099993 216 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1824 st053723 68.6 µM 1.92069308165249 0.0431232528703658 no 210 0.0273852061649603 245 675225 SGTC_2811 7967822 32.47 µM 1.91460498421305 0.0436239897665071 no 211 0.0277714495104176 242 2232244 SGTC_195 4234-0266 16.654 µM 1.91327310138266 0.0437341582766142 no 212 0.0278565496959656 296 2303354 SGTC_342 k048-0088 23.3 µM 1.90998597489031 0.0440070182614952 no 213 0.0280675095756702 235 6820570 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.90858559167484 0.0441236784403247 no 214 0.0281577860397749 241 688662 SGTC_746 1095-0025 46.6 µM 1.89255454762487 0.0454770007216662 no 215 0.0292085665574916 259 6749286 SGTC_2225 6654152 15.4 µM 1.89070934745362 0.0456348898696752 no 216 0.0293315769894659 178 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1928 4'-methoxychalcone 40.3 µM 1.88893641152613 0.0457870103917798 no 217 0.0294501748815601 213 641818 SGTC_2416 tofa 880 nM 1.88447743382187 0.046171399073298 no 218 0.0297502122072036 284 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2526 patulin 37.61 µM 1.88442038325544 0.0461763338895222 no 219 0.0297540674177717 363 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2441 5730946 39.09 µM 1.88393932864731 0.0462179614723597 no 220 0.0297865913248289 261 1774275 SGTC_820 1582-0060 59.9 µM 1.88056121078344 0.0465111330508415 no 221 0.0300158162265844 282 3848840 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.86352788069521 0.048012187275648 no 222 0.0311940168401101 299 6708561 SGTC_2333 9017922 200 µM 1.86307761185973 0.0480523869142929 no 223 0.0312256737910074 258 3163164 SGTC_873 0591-4978 488 µM 1.86024853406603 0.048305581378873 no 224 0.0314251856463953 265 3305145 SGTC_625 k213-0058 121 µM 1.8515770377464 0.0490883097361207 no 225 0.0320432914411357 444 3655420 SGTC_2769 toremifene 3.73 µM 1.84525600306078 0.0496652333895087 no 226 0.032500153663847 256 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_739 1486-1183 203 µM 1.84500565045742 0.0496881940930918 no 227 0.0325183583297 265 4346692 SGTC_3087 9117406 49.47 µM 1.83863389300115 0.0502754260335597 no 228 0.0329845263297274 244 42546093 SGTC_515 4092-1064 102 µM 1.82996578595271 0.0510831593044931 no 229 0.0336275275561492 357 717353 SGTC_2491 paeonol 100 µM 1.82795368815464 0.051272124745919 no 230 0.0337782512230762 215 11092 Increases levels of cortical cytochrome oxidase. SGTC_2706 st078239 82.5 µM 1.82366111678924 0.0516771186349067 no 231 0.0341016603411583 260 15434492 SGTC_2074 5212007 75.395 µM 1.81750970949611 0.0522619180393792 no 232 0.0345695514781118 218 758611 SGTC_2487 5918373 44.05 µM 1.80929984015402 0.0530505839927305 no 233 0.0352022169125319 285 2876279 SGTC_2921 7974240 10.71 µM 1.80748119808197 0.0532265589608229 no 234 0.0353436418405391 308 2979074 YDR527W RBA50 SGTC_1162 k048-0130 20.1 µM 1.79729117513104 0.0542211387264172 no 235 0.0361447032346785 275 6797406 SGTC_1677 st019204 53.9 µM 1.79657683566062 0.0542914085313266 no 236 0.0362014122899211 284 3945625 SGTC_1177 0983-0204 23.6 µM 1.79355510685683 0.0545894543360374 no 237 0.0364421037319963 284 766818 SGTC_850 0388-0143 75.9 µM 1.79328305261206 0.0546163515533263 no 238 0.0364638379297105 265 67273 SGTC_673 1082-0474 110 µM 1.79318865957433 0.0546256863686476 no 239 0.036471381392763 380 3098046 SGTC_2187 6125751 200 µM 1.79172754258078 0.0547703416412243 no 240 0.036588310184028 283 874498 SGTC_1546 5-methoxyflavanone 78.7 µM 1.78996384788358 0.0549453562599545 no 241 0.0367298617038118 272 147795 SGTC_2813 7971799 71.43 µM 1.78484042796466 0.0554562698894281 no 242 0.0371436018514062 270 2234054 SGTC_141 0443-0274 32.331 µM 1.78399882896423 0.0555405526893575 no 243 0.0372119277224527 429 1627241 SGTC_3037 9091026 49.47 µM 1.78232691166313 0.0557082885210364 no 244 0.0373479682912169 450 25236398 YIL048W NEO1 SGTC_2086 5274770 176.623 µM 1.77940264112263 0.0560026280634146 no 245 0.0375868868905391 297 689278 SGTC_1898 st060199 18.6 µM 1.77828124678209 0.0561158257502704 no 246 0.0376788373903129 256 688866 SGTC_1548 st061468 90.8 µM 1.7769095531088 0.0562545348261801 no 247 0.0377915611753716 255 390799 SGTC_569 4130-2812 160 µM 1.7697371983214 0.0569842281050309 no 248 0.0383854650435894 203 743552 SGTC_2962 9082311 13.18 µM 1.75728331791158 0.0582689295613478 no 249 0.0394347649026181 267 16459453 SGTC_192 3455-0609 60.9 µM 1.75483428967566 0.0585242199917282 no 250 0.0396438282519314 284 3769639 SGTC_3020 9089140 49.47 µM 1.74900038879975 0.0591358924243017 no 251 0.0401454761016294 311 17217859 SGTC_1057 3448-5381 134 µM 1.74865570842385 0.0591721877345051 no 252 0.0401752752330503 327 5497911 SGTC_2154 5570129 200 µM 1.74451535313411 0.0596095393785809 no 253 0.0405346333046058 321 673366 SGTC_3018 9082602 49.47 µM 1.74223374064231 0.0598516297058921 no 254 0.0407337761152946 316 17332089 SGTC_2197 6588183 93.1375 µM 1.74183067521525 0.059894476866858 no 255 0.0407690386927419 231 884136 SGTC_3082 9117008 49.47 µM 1.74126915905234 0.059954207899111 no 256 0.040818204774745 296 41448529 SGTC_1624 st003710 6.25 µM 1.73636144898322 0.060478251028446 no 257 0.0412499721231032 365 24207033 SGTC_961 1252-1571 372 µM 1.72954422732669 0.0612121297311587 no 258 0.0418558690367892 314 6813498 SGTC_1018 4259-0013 28.1 µM 1.72910260739859 0.0612599093814687 no 259 0.0418953662991827 297 6801262 SGTC_2029 5175081 200 µM 1.72907819879072 0.0612625510420102 no 260 0.0418975502171746 348 1380876 SGTC_516 3992-2719 87.3 µM 1.72752550734389 0.0614307765408853 no 261 0.0420366641336016 280 5350887 YDR037W KRS1 SGTC_1477 0139-0234 16 µM 1.7228636970916 0.0619380263246515 no 262 0.0424565883116193 282 620880 SGTC_1873 rapamycin 2 nM 1.71993048863271 0.062258859201262 no 263 0.0427225388471885 381 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1646 st011709 75.6 µM 1.71757381907626 0.0625175684164487 no 264 0.0429371895636005 252 5757843 SGTC_100 0086-0128 49.5915 µM 1.71691488161498 0.0625900546292118 no 265 0.0429973627023902 390 93297 SGTC_2656 pseudo-anisatin 100 µM 1.70881968805939 0.0634859192499938 no 266 0.0437421773229403 230 6708809 A neurotoxin. SGTC_609 0986-0026 86.3 µM 1.70544772945987 0.0638620125120359 no 267 0.0440554765294394 358 2848610 SGTC_2916 7875993 68.79 µM 1.69809679161118 0.0646879081201204 no 268 0.0447447475208464 333 1299250 SGTC_1007 4101-0031 70 µM 1.69410955797337 0.0651393403795958 no 269 0.0451222332127746 338 1146276 SGTC_1769 st044406 64.4 µM 1.68913837701885 0.0657055941564448 no 270 0.04559645744207 350 670903 SGTC_3267 9137951 49.47 µM 1.68646412297674 0.0660117857820112 no 271 0.0458532198682474 237 16643986 SGTC_1252 0493-0875 34.8 µM 1.68572136694391 0.0660970243128012 no 272 0.0459247396996455 329 3960963 SGTC_2855 9016525 58.44 µM 1.67837336805099 0.0669448796799554 no 273 0.0466371166561163 343 43811474 SGTC_1688 st021091 57.6 µM 1.67597673474678 0.067223229303816 no 274 0.0468713748888909 280 3656366 SGTC_2929 9013348 24.6 µM 1.66611166696323 0.0683784079263464 no 275 0.0478455875948928 352 2995952 SGTC_2314 7727897 200 µM 1.66462767772252 0.0685534974073315 no 276 0.0479935299536804 331 900724 SGTC_327 1273-0057 3.96 µM 1.66244179697703 0.068812029627199 no 277 0.0482121121265321 325 3108138 SGTC_1923 st058458 19.1 µM 1.66054291284752 0.0690372272763303 no 278 0.0484026412383724 390 3534982 SGTC_962 1254-0300 21.5 µM 1.65884517128238 0.0692390510294388 no 279 0.048573497679205 331 7340576 SGTC_1768 st044301 37.178 µM 1.65214764964578 0.0700396735969894 no 280 0.049252227655245 354 3931349 SGTC_2709 st078560 56 µM 1.64994673504739 0.0703043202460755 no 281 0.0494769154093799 321 17250903 SGTC_2488 5268135 45.7 µM 1.64766545660632 0.0705794410650352 no 282 0.04971067012768 439 1270356 YLR208W SEC13 SGTC_2163 5671233 125 µM 1.64762583624816 0.0705842265568805 no 283 0.0497147376598122 373 701023 SGTC_177 1327-0068 8.361 µM 1.64550440067328 0.0708408256569663 no 284 0.0499329179498396 389 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3355 9151058 44.0485 µM 1.64098007910072 0.0713904601304922 no 285 0.0504007752352126 327 17015728 SGTC_1999 st074831 12.5 µM 1.64079686522547 0.0714127865197898 no 286 0.0504197946096669 372 17112523 SGTC_2762 leflunomide 42.06 µM 1.63551275132876 0.0720590157445939 no 287 0.0509708019097964 395 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1393 3470-5649 58.2 µM 1.63238248633101 0.0724439455644234 no 288 0.0512994681215282 277 4108395 SGTC_3070 9117005 49.47 µM 1.62943058435871 0.0728083833918333 no 289 0.0516109493217169 257 8779016 SGTC_1200 1643-0193 18.4 µM 1.62932558679167 0.0728213720539334 no 290 0.0516220561732543 370 5403974 SGTC_1853 st056710 91.2 µM 1.62782969868654 0.0730066127379289 no 291 0.0517805006791266 357 269167 SGTC_686 1319-0111 510 µM 1.62770583955346 0.0730219667690074 no 292 0.0517936371501438 371 4562600 SGTC_1650 st011916 45.8 µM 1.62715465968902 0.0730903230111594 no 293 0.0518521272828082 310 242528 SGTC_1625 st003711 30.1 µM 1.62348992905083 0.0735460614551248 no 294 0.0522423572485434 346 24207034 YER133W GLC7 SGTC_629 3448-6466 76.7 µM 1.62004919104643 0.0739759193287788 no 295 0.0526108552475367 397 573744 SGTC_467 ro 31-8220 72.8 µM 1.60922529919393 0.0753406899333327 no 296 0.0537835431826411 426 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_98 0074-0023 107.663 µM 1.6075899179232 0.0755485513528319 no 297 0.0539625108884801 390 3563821 SGTC_1748 st037455 53.6035 µM 1.6051311024635 0.0758618955172121 no 298 0.0542324779110918 378 580690 SGTC_3221 9128209 49.47 µM 1.60262211971685 0.076182652091132 no 299 0.0545090535818604 326 16460723 SGTC_2534 helenine 20.12 µM 1.59981322009229 0.0765429745891518 no 300 0.0548200125787435 314 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3011 9081274 71.4286 µM 1.5994228166952 0.0765931575379702 no 301 0.0548633429208178 388 6625322 SGTC_1009 4106-0057 9.87 µM 1.59654319263219 0.076964081384521 no 302 0.0551837852092651 386 2928005 SGTC_2323 6148992 148.28 µM 1.59585734637547 0.0770526261082081 no 303 0.0552603232080761 329 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2353 9059630 146.67 µM 1.59174883611646 0.0775846682985485 no 304 0.0557205752136226 329 4779114 SGTC_1164 k060-0068 93.7 µM 1.58906343150101 0.0779339262031239 no 305 0.0560230363460793 406 5963676 SGTC_3141 9094609 49.47 µM 1.58852615319669 0.0780039464599547 no 306 0.0560837059768984 377 25236309 YDL196W YDL196W SGTC_2729 fluphenazine 10.66 µM 1.5799102280036 0.0791333380882896 no 307 0.0570637132912998 405 3372 An atypical antipsychotic. SGTC_3180 9109287 49.47 µM 1.57832142735403 0.0793429465440091 no 308 0.0572458928755826 329 18891271 SGTC_78 0336-0123 156.75 µM 1.57580458692942 0.0796758499214337 no 309 0.0575354224906684 343 6765896 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.5742904104956 0.0798766390461531 no 310 0.0577101628583005 403 5377381 SGTC_3074 9116018 49.47 µM 1.57289123969814 0.0800625176734534 no 311 0.0578720019527332 343 17027303 SGTC_2992 9074591 71.4286 µM 1.57173453133265 0.0802164321470247 no 312 0.058006065145737 359 17741321 SGTC_1119 parthenolide 318.541 nM 1.57052298498236 0.0803778831796975 no 313 0.0581467456746624 475 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3316 9136639 10.545 µM 1.56773146478099 0.0807508164634518 no 314 0.0584719076419515 347 4903665 SGTC_2565 isoliquiritigenin 100 µM 1.56717478094977 0.0808253426784001 no 315 0.0585369217498024 313 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3140 9094243 49.47 µM 1.56587736579755 0.0809992360589631 no 316 0.0586886648285183 396 19291112 SGTC_2281 7943571 200 µM 1.56030968201154 0.0817486834349122 no 317 0.0593433582438157 393 1244024 SGTC_2961 9083290 32.55 µM 1.55997114355775 0.0817944209853127 no 318 0.0593833502706981 347 17741490 SGTC_2332 7982454 138.89 µM 1.55049849886521 0.0830820371369214 no 319 0.0605109567602589 440 2981748 SGTC_2522 biochanin a 4.94 µM 1.54830135236255 0.0833828615464261 no 320 0.0607748795076985 355 5280373 A possible chelator. SGTC_3273 9137859 49.47 µM 1.54154434293922 0.0843131345736544 no 321 0.0615921797169431 339 2377234 SGTC_2673 kobusone 100 µM 1.53744491217467 0.0848813083939998 no 322 0.0620921976566183 351 6710676 An epoxy ketone and protein crosslinker. SGTC_1662 st014054 52 µM 1.53612859791743 0.0850643546987976 no 323 0.0622534218143235 333 2838777 SGTC_1706 st031321 9.9705 µM 1.52544417024291 0.0865610884533283 no 324 0.0635741743847857 387 6103185 SGTC_802 4112-3352 742 µM 1.5190210402353 0.0874703015036813 no 325 0.0643785999964443 457 704594 SGTC_2895 9054447 58.44 µM 1.5168633979646 0.0877773159530206 no 326 0.0646505882262749 360 2697450 SGTC_1965 Pectolinarigenin 58.4 µM 1.51633444764363 0.0878527036992993 no 327 0.0647174027081682 390 5320438 An anti-inflammatory. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.51219397435193 0.0884444868554275 no 328 0.0652422617432836 363 279621 SGTC_3158 9100007 49.47 µM 1.50618272615892 0.0893089322346395 no 329 0.0660101362708029 353 19297233 SGTC_156 3474-0145 5.642 µM 1.50367033102281 0.0896720830652444 no 330 0.0663331360649283 423 2265471 SGTC_3145 9085516 49.47 µM 1.4988523661422 0.0903715589137071 no 331 0.0669559680247704 413 25236195 SGTC_2911 7942208 15.64 µM 1.49851961842055 0.090420016643172 no 332 0.066999149700443 363 1243384 SGTC_2301 7769476 200 µM 1.49686194271098 0.0906617098541278 no 333 0.0672145922962428 373 977820 SGTC_2359 9039622 200 µM 1.49587843646037 0.0908053339536413 no 334 0.0673426682706483 423 6463596 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.49413378264769 0.0910605257755261 no 335 0.0675703278445914 301 279621 SGTC_1298 1079-1278 263 µM 1.4938685226471 0.0910993720947601 no 336 0.0676049935966653 448 2840950 SGTC_1046 2001-0062 216 µM 1.49240661156628 0.0913136839623551 no 337 0.0677962914198564 435 739778 SGTC_2284 7945075 39.21 µM 1.49224965824721 0.0913367150581148 no 338 0.0678168543154578 474 1245402 SGTC_329 k048-0121 21.3 µM 1.48914203625607 0.0917936100110409 no 339 0.0682249852266462 403 6832902 SGTC_2987 9018338 71.43 µM 1.4890088171506 0.0918132341901913 no 340 0.0682425234701 438 5055682 SGTC_536 3852-0578 10.6 µM 1.48832893510195 0.0919134343466307 no 341 0.0683320838742293 403 2869208 SGTC_2970 9090938 41.86 µM 1.4775763530663 0.0935089207187174 no 342 0.0697606037928715 526 17217104 SGTC_1262 0737-0114 49.6 µM 1.47736284374568 0.0935408074063304 no 343 0.0697892002762066 508 765919 SGTC_116 0155-0182 31.788 µM 1.47158911023131 0.0944061366067438 no 344 0.0705659340053467 588 771486 SGTC_231 b-estradiol 524 µM 1.46912748280276 0.0947768586489861 no 345 0.0708991073691792 360 450 A steroid. SGTC_1151 3909-8316 15.3 µM 1.46779121811596 0.0949785493214198 no 346 0.0710804718248844 446 800431 SGTC_848 0368-0089 85.6 µM 1.46612517004105 0.095230458871118 no 347 0.0713070948845664 450 762535 SGTC_1439 4092-1168 46 µM 1.46324798900979 0.0956666518089866 no 348 0.0716997669242729 424 2886240 SGTC_1608 st001473 40.5 µM 1.46102914389087 0.0960040408674573 no 349 0.0720037217920908 443 7292267 SGTC_2767 sibutramine 71.45 µM 1.45707117484783 0.0966080454396141 no 350 0.0725483671288591 445 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1183 1254-0324 198 µM 1.45673496594857 0.0966594808302722 no 351 0.0725947769400318 446 5799357 SGTC_1017 4239-0030 168 µM 1.45517773777589 0.0968979779215165 no 352 0.072810031179384 495 1149593 SGTC_59 0330-0160 1.33 µM 1.45505037242306 0.0969175036436977 no 353 0.0728276583722918 615 4293482 SGTC_2326 6164455 177.58 µM 1.45198943633758 0.0973876291704223 no 354 0.0732522712608624 426 2888790 SGTC_1441 4106-0040 13 µM 1.44793770043756 0.0980125003364473 no 355 0.0738172373621315 434 2904180 SGTC_1927 st060202 13.8 µM 1.4398869297287 0.0992628240358192 no 356 0.074949695753166 439 688887 SGTC_711 k292-0785 179 µM 1.43934892919462 0.0993467919499691 no 357 0.075025843168819 457 4146315 SGTC_2889 9059656 51.95 µM 1.43367850625326 0.100234957376085 no 358 0.0758320143051041 488 3949838 SGTC_2134 5324836 1.464 µM 1.4308182974257 0.100685148306726 no 359 0.0762411488246661 387 699272 SGTC_3313 9133968 57.047 µM 1.4235575997546 0.101834586805881 no 360 0.0772872885592639 478 1494643 SGTC_1809 st050081 57.6 µM 1.42297239614167 0.1019276444453 no 361 0.0773720787361264 449 5036894 SGTC_602 3130-1533 38.1 µM 1.42241924308297 0.102015662366607 no 362 0.0774522900458847 520 720941 SGTC_3143 9086658 49.47 µM 1.42066596167128 0.102295010608161 no 363 0.0777069462244158 533 25236626 SGTC_3275 9138069 49.47 µM 1.41854838854734 0.102633142246645 no 364 0.0780153609379349 427 17617007 SGTC_2081 5214970 32.255 µM 1.41633618861054 0.102987250697662 no 365 0.0783385485825888 453 2063512 SGTC_1437 4092-1038 11.6 µM 1.41592988195355 0.103052384856799 no 366 0.0783980174699427 481 3977136 SGTC_3184 9108758 49.47 µM 1.41483731448975 0.103227680426273 no 367 0.0785581003735316 432 902885 SGTC_1494 4358-1428 177 µM 1.41114537181952 0.103821631200515 no 368 0.0791008769816827 492 1564571 SGTC_1412 3909-8563 178 µM 1.40652308803233 0.104568742547847 no 369 0.0797844268323867 520 23767530 SGTC_2528 xanthyletin 44.79 µM 1.40445523029981 0.104904233560693 no 370 0.0800916671364713 441 65188 An natural product with antifungal activity of unknown mechanism. SGTC_749 1000-0129 128 µM 1.40267693614677 0.105193368184892 no 371 0.080356598970392 527 708470 SGTC_1442 4112-3290 3 µM 1.401668703285 0.105357553707774 no 372 0.0805071002573181 491 704353 SGTC_2872 9044037 25.97 µM 1.40160273381934 0.105368302953139 no 373 0.08051695509152 390 6465195 SGTC_2455 5377712 9.75 µM 1.40047745704306 0.105551780829288 no 374 0.0806851946910155 435 2243908 SGTC_697 0508-1955 564 µM 1.40014260763158 0.105606423050407 no 375 0.0807353090859429 524 6243113 SGTC_3041 9091929 49.47 µM 1.3984497098481 0.105882990789591 no 376 0.0809890322368709 495 25236887 SGTC_2267 7931562 200 µM 1.39619214860777 0.1062526212444 no 377 0.0813283201987434 439 934880 SGTC_1090 efavirenz 20.7 µM 1.39316833775215 0.106749168632365 no 378 0.0817844459419325 489 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_573 3702-0553 84.7 µM 1.38970906188089 0.107319275916541 no 379 0.0823086209776929 481 1222756 SGTC_2217 6934799 96.0675 µM 1.38967857522683 0.107324310019895 no 380 0.0823132517609708 461 675606 SGTC_2306 7482397 179.52 µM 1.38957347427683 0.107341666100691 no 381 0.0823292176185306 496 891448 SGTC_3274 9138298 49.47 µM 1.38790556084516 0.10761737160543 no 382 0.0825829021600732 518 17015756 SGTC_3046 9092212 49.47 µM 1.38405125998903 0.108256437248008 no 383 0.0831713797635658 459 25236637 SGTC_222 nsc-310342 10.666 µM 1.38311810215536 0.108411570135462 no 384 0.0833143279982603 345 432556 SGTC_849 0386-0493 241 µM 1.3822598818071 0.108554386181958 no 385 0.083445959709033 462 726119 SGTC_1291 0993-0025 5.79 µM 1.38025291621725 0.108888892570162 no 386 0.0837543931911087 484 4353356 SGTC_878 0828-0289 13.7 µM 1.37738527183273 0.109368135526143 no 387 0.0841965819858618 563 745350 YLR208W SEC13 SGTC_2580 diallyl disulphide 81.36 µM 1.37627829671679 0.109553538794848 no 388 0.0843677447746822 461 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_237 nikkomycin 200 µM 1.37562158564053 0.109663635568296 no 389 0.084469410123167 511 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2357 9067248 200 µM 1.37345522546024 0.110027386260621 no 390 0.0848054357503718 454 9150235 SGTC_1597 7-benzyloxygramine 47.5 µM 1.37028700261838 0.110560915887462 no 391 0.0852986643467349 656 260807 SGTC_538 2922-0838 53.3 µM 1.37026709697991 0.110564273854644 no 392 0.0853017700335943 586 777039 SGTC_3066 9117245 49.47 µM 1.37025142388727 0.110566917867032 no 393 0.0853042154163185 505 17176980 SGTC_3023 9089636 49.47 µM 1.36953100031034 0.110688500486375 no 394 0.0854166756701084 507 17249241 SGTC_2947 9072639 7.68 µM 1.36944120478274 0.110703661583045 no 395 0.0854307007976422 545 16488146 SGTC_2259 7964009 200 µM 1.36941274348395 0.110708467305583 no 396 0.085435146516485 455 313134 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.36010023456212 0.112288930944778 no 397 0.0868991034354645 565 6708784 An antioxidant flavonoid SGTC_2471 5466956 24.79 µM 1.35673596415277 0.11286384067884 no 398 0.0874325603994912 459 724419 SGTC_2956 9076196 2.52 µM 1.34752024278383 0.114449440015467 no 399 0.0889063691898122 523 16423868 SGTC_582 0987-0078 156 µM 1.33986325442868 0.115778864067374 no 400 0.0901449031849878 658 1625765 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.33777069074923 0.116144080412969 no 401 0.0904855994638124 600 551469 SGTC_3334 9142812 21.919 µM 1.33563545240719 0.116517586849826 no 402 0.0908342282201182 521 45283678 SGTC_2940 9060638 45.86 µM 1.32505338350113 0.118381227125061 no 403 0.092576723020239 541 4027022 SGTC_1426 4048-4480 71.7 µM 1.3211601649212 0.119072147600535 no 404 0.0932239827595967 549 14224343 SGTC_3088 9117578 49.47 µM 1.31947638996372 0.119371843456441 no 405 0.0935049491142654 506 678341 SGTC_2367 9070478 135.38 µM 1.30959024669728 0.12114222042781 no 406 0.0951672448421342 562 572802 SGTC_2883 9059145 45.46 µM 1.30800813776919 0.12142724459362 no 407 0.0954352745645744 502 16476510 SGTC_405 ebelactone b 50 µM 1.30540175386268 0.121897824084963 no 408 0.0958780407455668 555 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3172 9105863 49.47 µM 1.30331007398702 0.122276399826014 no 409 0.0962344616006826 438 2348785 SGTC_482 fipronil 114 µM 1.30059058575159 0.12276983639711 no 410 0.0966993155845603 464 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1071 trifluoperazine 6.31 µM 1.29982334834705 0.122909299743698 no 411 0.0968307606067699 564 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_186 3455-3465 67.277 µM 1.29748593459898 0.12333486395101 no 412 0.0972320207870053 424 755278 SGTC_2195 6536160 144.242 µM 1.29738881488347 0.123352568486665 no 413 0.0972487195391445 470 3834386 SGTC_2892 9047358 58.44 µM 1.29581912279761 0.123638964049614 no 414 0.0975189041221468 498 6466771 SGTC_1404 3909-7820 48.3 µM 1.29036612711142 0.124637498405941 no 415 0.0984617835695048 538 23741373 SGTC_397 arbidol 50 µM 1.28808598917141 0.125056696449598 no 416 0.0988580159726953 579 131410 A RNA synthesis inhibitor. SGTC_2465 5809242 33.21 µM 1.28443773737243 0.125729465505694 no 417 0.0994944179553912 518 2731748 SGTC_1194 1488-0194 225 µM 1.28295445649072 0.126003715920711 no 418 0.0997540162503286 595 1391452 SGTC_6 0844-0013 19.835 µM 1.28227119906576 0.126130186651449 no 419 0.0998737637478111 799 1584900 SGTC_936 3005-4620 401 µM 1.27820173561161 0.126885276004202 no 420 0.100589152169188 616 777207 SGTC_133 0724-0033 378.92 µM 1.27802011674308 0.126919048602922 no 421 0.100621166641497 528 280309 SGTC_630 4356-0227 183 µM 1.27738667220679 0.127036888571227 no 422 0.100732883870749 534 779312 SGTC_1831 st055328 12 µM 1.2766186011 0.127179875290344 no 423 0.100868465776896 575 1103068 SGTC_1564 D-Arginine 115 µM 1.27529672274617 0.127426222756115 no 424 0.101102118642695 547 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1154 4088-0362 150 µM 1.27328996998229 0.127800838522206 no 425 0.101457582280543 636 6618304 SGTC_54 0159-0055 9 µM 1.27239649896586 0.127967875547343 no 426 0.101616138691244 558 3319099 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.2720517451387 0.128032368823393 no 427 0.10167736732668 537 5355888 SGTC_1745 st081495 74 µM 1.2714287299281 0.128148973863817 no 428 0.101788083595768 624 13842402 YBL026W LSM2 SGTC_2356 9061756 188.97 µM 1.27135510928864 0.128162757752931 no 429 0.1018011725433 518 20104043 SGTC_1385 3091-4834 14.1 µM 1.26564700670239 0.129234613998982 no 430 0.102819744392621 526 4072814 SGTC_2722 naftopidil 47.16 µM 1.26408659898861 0.129528702669816 no 431 0.103099473016922 596 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1228 0124-0032 52.5 µM 1.26294218280545 0.129744684280027 no 432 0.103304979399781 591 X1228 SGTC_656 4090-1979 187 µM 1.26044801405139 0.130216263642232 no 433 0.103753895112315 615 22330961 SGTC_2308 7584454 197.62 µM 1.26008417356248 0.130285154962962 no 434 0.10381949944303 631 893577 SGTC_1268 0828-0275 2.46 µM 1.25735154506296 0.130803369947752 no 435 0.104313183409876 583 745337 SGTC_3094 9117742 49.47 µM 1.25620908130239 0.131020448252609 no 436 0.104520087535216 627 17149698 SGTC_2945 9067681 61.76 µM 1.25363203201097 0.131511024182759 no 437 0.10498789142165 551 16456930 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.24596616524527 0.132977814355832 no 438 0.106388408536703 568 5357218 A potent inhibitor of glutathione S-transferases. SGTC_131 0141-0277 33.849 µM 1.24385691841821 0.133383366733165 no 439 0.106776113793677 594 1547771 SGTC_657 3534-0529 86.7 µM 1.24322098718865 0.133505806248195 no 440 0.106893205488033 565 1049549 SGTC_96 0929-0093 37.281 µM 1.23972251154971 0.134180770181156 no 441 0.107539023863324 548 6991579 SGTC_1955 wogonin 32.4 µM 1.23959765891811 0.134204901348608 no 442 0.107562123502521 558 5281703 A flavanone. SGTC_992 3909-8734 162 µM 1.2347149889871 0.135150948411927 no 443 0.108468297715052 576 4288319 SGTC_2618 avocadyne 43.43 µM 1.23282441670936 0.135518483445849 no 444 0.108820639808277 570 3015189 SGTC_2446 5162541 200 µM 1.23227486966492 0.135625446002986 no 445 0.108923211967696 563 1549321 SGTC_1155 4088-0394 48.2 µM 1.23177724447061 0.13572235249725 no 446 0.109016152935915 600 2326248 SGTC_2657 nystatin 74.44 µM 1.22838584313963 0.136384049862773 no 447 0.109651079850684 620 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2683 piperine 63.03 µM 1.22829278876079 0.136402236786251 no 448 0.109668538527615 574 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2283 7944793 200 µM 1.22717780269559 0.13662028320232 no 449 0.109877885221725 600 2970533 SGTC_3092 9117248 49.47 µM 1.22530685380812 0.136986700813881 no 450 0.11022981350849 637 17141857 SGTC_549 1661-1316 519 µM 1.22301975744889 0.137435530647685 no 451 0.110661117001596 618 2857282 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.22279885012952 0.137478935583448 no 452 0.110702839942925 639 2724 A muscle relaxant with antifungal properties. SGTC_2772 vinpocetine 57.06 µM 1.21999502620126 0.138030657682288 no 453 0.111233380200216 589 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1204 4049-0315 18.3 µM 1.21745385448322 0.138531999265295 no 454 0.11171579172063 604 588402 SGTC_1051 3253-3903 78 µM 1.21681654253824 0.138657927350497 no 455 0.111837012277993 630 5509239 SGTC_2589 lobaric acid 100 µM 1.21658618876182 0.13870346271862 no 456 0.111880850086231 596 73157 A novel microtubule depolymerizer. SGTC_1233 0325-0408 14.2 µM 1.21577224870384 0.138864440551264 no 457 0.112035846543204 595 12874 SGTC_3130 9127414 49.47 µM 1.21451384363569 0.139113573221197 no 458 0.112275783345791 601 1494646 SGTC_2877 9040724 71.43 µM 1.21450684071419 0.139114960474828 no 459 0.112277119601158 596 6463895 SGTC_3053 9095903 49.47 µM 1.21393600429794 0.139228072787984 no 460 0.112386081397006 595 17174018 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.21040365508484 0.139929406172675 no 461 0.113062020028999 665 1273210 SGTC_1758 st042942 75.2445 µM 1.20718759722505 0.140570025902573 no 462 0.11367995291571 614 669317 SGTC_1672 st016598 6.51 µM 1.20659241068649 0.140688801508422 no 463 0.11379457547064 622 4665860 YNL267W PIK1 SGTC_851 0394-0702 453 µM 1.20612410310226 0.140782304976087 no 464 0.113884821234679 673 762646 SGTC_51 1013-0126 23.419 µM 1.20539711397853 0.140927540967946 no 465 0.114025017546989 588 1627850 SGTC_698 k064-0052 127 µM 1.20339557417411 0.14132792834134 no 466 0.114411639879176 569 5088751 SGTC_2472 5377652 49.4 µM 1.20037889095937 0.141932840226569 no 467 0.114996111606483 654 1610903 SGTC_3203 9113543 49.47 µM 1.19919916516913 0.142169877534895 no 468 0.11522525590867 589 17018012 SGTC_478 N-arachidonylglycine 10 µM 1.19892049696374 0.142225908251074 no 469 0.115279430449685 477 5283389 SGTC_1897 st060201 15 µM 1.19865116113723 0.142280076741433 no 470 0.11533180793151 583 611878 SGTC_1166 k206-0078 225 µM 1.19773373949742 0.142464692197993 no 471 0.115510344969984 651 5404595 SGTC_442 cape 100 µM 1.1947692145332 0.14306235960588 no 472 0.116088605731059 570 5281787 SGTC_204 PMA1.184 62.41 µM 1.18825717287462 0.144381169680626 no 473 0.117366052518909 678 2252213 YGL008C PMA1 SGTC_1911 st060208 74.3 µM 1.18535179932184 0.14497219706748 no 474 0.11793919045676 668 688783 SGTC_1361 1608-0041 5.61 µM 1.18343317431946 0.145363386215421 no 475 0.118318758095072 645 X1361 SGTC_545 4218-0007 221 µM 1.1830163830459 0.145448459733285 no 476 0.118401327283108 615 2840508 SGTC_3121 9125696 49.47 µM 1.18218251913844 0.145618764699761 no 477 0.118566643640548 596 1235365 SGTC_493 zm226600 134 µM 1.18184401960027 0.145687936711467 no 478 0.118633798850868 645 5240098 A potassium channel opener. YCR052W RSC6 SGTC_368 fentichlor 4.58 µM 1.1783217392195 0.146409021626842 no 479 0.119334182155265 543 7329 A pesticide. SGTC_1357 1503-1303 39.5 µM 1.17829217752551 0.14641508364952 no 480 0.119340072633707 676 292895 SGTC_3147 9097027 49.47 µM 1.177867926882 0.146502100508274 no 481 0.119424631639658 667 25236841 SGTC_3225 9130819 49.47 µM 1.17785449626641 0.146504855790888 no 482 0.11942730923678 637 4547121 SGTC_938 3126-1755 342 µM 1.17087914982428 0.147940544930223 no 483 0.120823678540383 684 1777771 SGTC_1033 k072-0102 21.3 µM 1.1684652475358 0.14843956859201 no 484 0.121309574707813 667 5965931 SGTC_2132 5317594 122.667 µM 1.16835065069281 0.148463287042265 no 485 0.121332676106273 577 794577 SGTC_579 4491-1009 110 µM 1.16821207173162 0.148491972528359 no 486 0.121360616154436 819 1271041 SGTC_1301 naphtanilide LB 4.81 µM 1.16444674295754 0.149272804328724 no 487 0.122121507064373 683 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1806 st050005 60.3 µM 1.16287941752698 0.149598633734658 no 488 0.122439214682225 633 5194765 SGTC_3210 9128157 49.47 µM 1.16230843498492 0.149717452462579 no 489 0.122555100779394 596 17590849 SGTC_3103 9120822 49.47 µM 1.16078274590557 0.15003524983816 no 490 0.122865130716343 683 17141819 SGTC_3057 9095946 49.47 µM 1.16018705421057 0.15015945298441 no 491 0.122986328297168 655 24540043 SGTC_624 k048-0052 28 µM 1.1598765372304 0.150224223685841 no 492 0.123049538338544 626 6835531 SGTC_1661 st013063 9.66 µM 1.15870632056174 0.150468486343469 no 493 0.123287956801006 708 721395 SGTC_2759 disulfiram 3.38 µM 1.15869094495934 0.150471697496787 no 494 0.123291091559698 619 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2838 9002687 71.43 µM 1.15755816344181 0.150708401459412 no 495 0.123522195288136 599 6457060 SGTC_1444 4112-3581 28 µM 1.15664732119749 0.150898909133238 no 496 0.123708240145831 659 2877249 SGTC_1684 st024538 14.6195 µM 1.15555281323944 0.151128043451391 no 497 0.123932059212811 664 6732859 SGTC_1267 0828-0272 9.49 µM 1.15492410512348 0.151259767589351 no 498 0.124060753616198 698 745334 SGTC_2724 maprotiline 69.64 µM 1.15401015082748 0.151451391405669 no 499 0.124248003662453 664 4011 A tricyclic antidepressant. SGTC_1373 2887-0003 58.5 µM 1.15079977218616 0.152125772820984 no 500 0.124907309273028 645 776948 SGTC_1802 st050112 57.9 µM 1.14940694638271 0.152418973129359 no 501 0.125194108536021 673 4662563 SGTC_212 3807-4682 38.772 µM 1.14873339757314 0.152560894668471 no 502 0.125332965005719 819 3125501 YBL034C STU1 SGTC_2822 7994718 71.43 µM 1.14451869696102 0.153450952542005 no 503 0.126204294232352 570 1018011 SGTC_2990 9074105 71.4286 µM 1.14318070890367 0.153734225845819 no 504 0.126481785019522 623 6502001 SGTC_3036 9090181 49.47 µM 1.1431052364331 0.153750214873121 no 505 0.126497450216526 659 25236586 SGTC_2341 7987486 176.74 µM 1.14294493998293 0.153784177719554 no 506 0.126530726109679 695 1258686 SGTC_71 0417-1750 47.813 µM 1.14234424663134 0.153911493928912 no 507 0.126655478102884 705 6811472 SGTC_555 4296-0685 37 µM 1.14097691430659 0.154201558340951 no 508 0.126939765009354 683 2908540 YHR072W ERG7 SGTC_3079 9117512 49.47 µM 1.14014584207897 0.154378037662585 no 509 0.127112773047092 708 7185044 SGTC_2304 7443016 91.4 µM 1.13883678597086 0.154656288244866 no 510 0.127385617779892 600 939854 SGTC_2965 9082772 38.63 µM 1.13734136573798 0.154974557341312 no 511 0.127697804247092 715 16459634 SGTC_782 0083-0095 30.5 µM 1.13606849392751 0.155245802175651 no 512 0.127963949795201 712 3591729 An indicator and reagent. SGTC_1147 3809-1045 12.3 µM 1.13462358463266 0.155554087165586 no 513 0.12826653351666 657 325925 SGTC_713 1488-1073 324 µM 1.13406558311398 0.155673250056962 no 514 0.12838351952456 689 3312542 SGTC_800 3448-7362 155 µM 1.13363350391368 0.155765563207929 no 515 0.128474156566491 917 15991913 SGTC_289 k017-0060 526 µM 1.13172459712451 0.156173830542317 no 516 0.128875118538335 642 5512909 SGTC_2885 9057732 51.95 µM 1.13110047741344 0.156307466914816 no 517 0.129006401696242 657 6471414 SGTC_585 0kpi-0023 191 µM 1.13091592434981 0.15634699780078 no 518 0.129045240068041 633 64601 SGTC_3285 9112818 20.8695 µM 1.12856389850031 0.156851373566919 no 519 0.129540923606672 716 17017947 YPR165W RHO1 SGTC_3286 9117135 37.221 µM 1.12854620255809 0.156855172393399 no 520 0.129544657974605 645 3438150 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.12274259967764 0.158104310186508 no 521 0.130773414980007 736 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1181 1222-0449 220 µM 1.12220982723228 0.158219307727674 no 522 0.130886617615382 702 658318 SGTC_830 4076-0286 57.8 µM 1.11878086043363 0.158960754437428 no 523 0.131616819429839 826 6866659 SGTC_159 3970-0959 50 µM 1.11813683369873 0.159100266134386 no 524 0.131754278556726 893 6615653 SGTC_2368 9071271 200 µM 1.1168808846729 0.159372565604273 no 525 0.132022629394253 660 27209959 SGTC_2227 7312221 64.1025 µM 1.11585271191375 0.159595708433009 no 526 0.132242593097834 684 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2801 7907800 81.82 µM 1.1132755121193 0.160155932516035 no 527 0.132795060091395 716 6620925 SGTC_3167 9103034 49.47 µM 1.1086024376467 0.161175026653708 no 528 0.133800863040954 645 5127859 SGTC_36 0335-0881 14.2 µM 1.10851562700397 0.161193998074092 no 529 0.133819597023611 753 23828853 SGTC_2764 methyldopa 94.69 µM 1.10447547476955 0.16207853623756 no 530 0.134693468287368 729 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3109 9122853 49.47 µM 1.1016539305521 0.162698147375722 no 531 0.135306076302717 756 1234709 SGTC_667 1498-1044 59 µM 1.09963464860105 0.163142526371816 no 532 0.135745669537994 733 6739982 SGTC_557 1315-0110 16.2 µM 1.09434421256369 0.164310517977097 no 533 0.136902020665646 711 6833801 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.09311014467487 0.16458374623654 no 534 0.137172721188153 655 5282362 SGTC_689 0833-0039 98 µM 1.09176200122848 0.164882567659711 no 535 0.13746886254426 740 5374726 SGTC_895 0964-0006 13.7 µM 1.09166407228397 0.164904287685076 no 536 0.137490391201644 714 6738897 SGTC_985 1493-0307 8.71 µM 1.09144065740654 0.16495384663832 no 537 0.137539515248349 660 3278274 SGTC_254 nsc-64875 3.808 µM 1.0876732632711 0.165791000291072 no 538 0.138369687509855 720 56993 SGTC_1260 0700-1617 7.75 µM 1.0846344603317 0.166468251139527 no 539 0.139041793046731 737 2853078 SGTC_3352 9151559 45.5865 µM 1.0838906097964 0.166634303082277 no 540 0.139206651784026 687 17159339 SGTC_2109 5483026 200 µM 1.08176883731717 0.167108539702913 no 541 0.139677628419941 745 759335 SGTC_3279 9140807 49.47 µM 1.07989238325706 0.167528669667055 no 542 0.140095052725578 727 45595718 SGTC_1972 st070201 17.4 µM 1.07513532923771 0.168596799725852 no 543 0.141157072068764 732 2829099 SGTC_391 gliotoxin 8.33 µM 1.07451127117248 0.168737247367508 no 544 0.141296797923622 772 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_200 k038-0079 37.545 µM 1.07403425629631 0.168844652830803 no 545 0.14140366418512 692 3436683 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.07151417591649 0.169412807139241 no 546 0.141969150063933 727 756377 SGTC_2279 7948423 32.93 µM 1.07000348250718 0.169753981791954 no 547 0.142308870584558 674 1247112 SGTC_2451 5856223 45.7 µM 1.06875023019633 0.17003735016966 no 548 0.142591115544393 712 2179896 SGTC_1778 st046819 58.9 µM 1.06715591657818 0.170398272605578 no 549 0.142950717660555 777 671715 SGTC_1709 st033179 39.1045 µM 1.06672815204507 0.170495193827716 no 550 0.143047305389488 769 573381 SGTC_220 paclitaxel 373.376 µM 1.06568881153647 0.170730830607452 no 551 0.143282168508998 660 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2714 st079313 56.9 µM 1.06317115974993 0.171302490112158 no 552 0.143852169340784 719 2939799 SGTC_594 1487-1584 10.8 µM 1.06150373812522 0.171681768655109 no 553 0.144230517500437 731 5013332 SGTC_1419 3993-2473 62.6 µM 1.06056364188019 0.171895843094793 no 554 0.144444126552364 749 704026 SGTC_2844 9010103 25.97 µM 1.06014966764775 0.171990165454273 no 555 0.144538257519638 720 2480525 SGTC_3012 9080433 71.4286 µM 1.05808162298566 0.172461855791739 no 556 0.145009115888414 782 17688859 SGTC_3110 9122132 49.47 µM 1.05502036577119 0.173161596245366 no 557 0.145708005268591 772 918317 SGTC_383 2324-0395 7.37 µM 1.05384029594272 0.173431818124681 no 558 0.145978020590271 751 3146421 SGTC_2426 5582046 32.21 µM 1.05307793575233 0.173606532127694 no 559 0.146152637161728 768 2251934 SGTC_447 ml7 120 µM 1.05291194400745 0.173644588150859 no 560 0.14619067572061 775 4216 Selective myosin light chain kinase inhibitor. SGTC_163 TUB2.036 7.546 µM 1.05252947958747 0.173732293887415 no 561 0.14627834632401 887 15992207 YJR013W GPI14 SGTC_2121 5257820 149.641 µM 1.05083422772609 0.174121383790544 no 562 0.146667366309313 813 791256 SGTC_604 1000-0114 314 µM 1.05065804385977 0.174161852813686 no 563 0.146707836104204 824 1572745 SGTC_331 k048-0133 24.5 µM 1.05049591138613 0.174199099546174 no 564 0.146745084884984 701 6813582 SGTC_1488 4013-0813 75.9 µM 1.04763770014718 0.174856548217625 no 565 0.147402780469495 714 2910057 SGTC_995 3931-2021 34.6 µM 1.04085724659253 0.17642248453001 no 566 0.148970903281629 745 730143 SGTC_206 4546-0025 72.014 µM 1.04057927283205 0.176486870925797 no 567 0.149035427519974 818 6620745 YIL048W NEO1 SGTC_1990 st072050 59.8 µM 1.04054065224213 0.176495817696297 no 568 0.149044393742826 772 17233948 SGTC_998 3996-0085 177 µM 1.03867657283773 0.176927987744226 no 569 0.149477590070605 833 715391 SGTC_2344 7990960 76.95 µM 1.03690347397374 0.177339684797868 no 570 0.149890422378318 728 140813 SGTC_3245 9134821 49.47 µM 1.03324680549493 0.178190637428512 no 571 0.150744207027103 778 17014901 SGTC_210 3551-0445 56.827 µM 1.03137952191522 0.178626168752628 no 572 0.151181440040727 763 2865180 YOR207C RET1 SGTC_2414 st077232 92.9 µM 1.02960804865901 0.179039972050011 no 573 0.151597017732917 710 729801 SGTC_2913 7966556 36.57 µM 1.02854856582311 0.179287747549724 no 574 0.151845929022369 753 2976516 SGTC_2328 6201408 200 µM 1.02643167628609 0.179783458494474 no 575 0.152344076709482 739 2890418 SGTC_3314 9135860 59.4275 µM 1.02251573272883 0.180702719997391 no 576 0.153268435135176 800 25252478 SGTC_2078 5212016 200 µM 1.02099598982291 0.181060269616469 no 577 0.15362816932952 748 1899708 SGTC_3115 9123671 49.47 µM 1.01944942857399 0.181424583492112 no 578 0.153994825109565 823 3286988 SGTC_496 calpeptin 138 µM 1.01693130824936 0.182018742649053 no 579 0.154593054132775 692 73364 A calpain inhibitor. SGTC_3335 9143315 29.6265 µM 1.0166313332133 0.182089603803229 no 580 0.154664421348322 771 4899691 SGTC_1613 st002381 52.1 µM 1.016541062648 0.182110931207845 no 581 0.154685901925923 797 551167 SGTC_1409 3909-8004 61.9 µM 1.01624630086488 0.182180582764705 no 582 0.154756056494065 812 2119279 SGTC_2158 5657123 3.6195 µM 1.01511955272521 0.182446984302502 no 583 0.155024421113221 790 2858827 SGTC_1417 3966-0327 90.4 µM 1.01433544017086 0.182632518674413 no 584 0.155211359315997 842 651118 SGTC_842 0271-0008 11.1 µM 1.01322600474161 0.182895231172553 no 585 0.155476110997096 840 1221709 SGTC_1836 st055642 81 µM 1.01306306419613 0.182933835081226 no 586 0.155515019621208 778 8571 SGTC_1172 0370-0043 85 µM 1.0130464975821 0.182937760331701 no 587 0.155518975927911 780 376585 SGTC_2882 9058044 58.44 µM 1.01242396459429 0.183085299775199 no 588 0.155667692420994 745 18076804 SGTC_259 usnic acid 108.925 µM 1.01186799967382 0.183217125411526 no 589 0.155800585770365 808 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3223 9129970 49.47 µM 1.01121541409652 0.18337193641239 no 590 0.155956669944322 811 17248386 SGTC_2881 9058953 51.95 µM 1.01101075021574 0.183420505031229 no 591 0.15600564228496 848 17122249 SGTC_2893 9048488 25.97 µM 1.01075272573552 0.183481748037712 no 592 0.156067397287667 756 6467338 SGTC_2952 9073731 13.78 µM 1.00994891306035 0.183672617458263 no 593 0.156259883269453 822 16457353 SGTC_1539 benzyladenosine 56 µM 1.00469453114679 0.184923342706479 no 594 0.157521981169555 770 92208 A nucleotide analog. SGTC_2760 etidronate 98.04 µM 1.00373796407062 0.185151607023939 no 595 0.157752466506027 738 3305 A chelator and antioxidant. SGTC_2993 9054257 71.4286 µM 1.0030583150057 0.185313897066258 no 596 0.157916362843218 800 6470217 YGL055W OLE1 SGTC_472 calcifediol 10 µM 1.00296310665063 0.185336638449933 no 597 0.157939331118428 744 5283731 A vitamin D metabolite. SGTC_2153 5569715 200 µM 1.00246620353049 0.185455356409052 no 598 0.15805924072794 793 2054701 SGTC_1156 4092-0367 4.88 µM 1.00200711999728 0.185565080614859 no 599 0.158170077044435 797 1357585 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.0019552572792 0.185577478702785 no 600 0.158182601441486 1012 16725076 SGTC_726 3448-4391 34.2 µM 1.00171188094875 0.185635666112366 no 601 0.15824138340983 840 1356692 SGTC_3102 9121669 49.47 µM 1.00031826844043 0.185969074654569 no 602 0.158578254541523 766 41905072 SGTC_2907 7721985 69.9 µM 0.997459513359952 0.186654165700765 no 603 0.159270758171824 784 3267881 SGTC_3078 9116413 49.47 µM 0.996311711804236 0.186929671551423 no 604 0.159549357515411 752 17177322 SGTC_2938 9059746 27.26 µM 0.996187408105528 0.186959523157563 no 605 0.159579548176114 761 6471769 SGTC_2017 5132927 60.65 µM 0.995869535823458 0.187035873786767 no 606 0.159656769434102 797 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1180 1193-0155 285 µM 0.995450311529047 0.187136597927464 no 607 0.159758649694953 752 2921347 SGTC_693 4161-2696 114 µM 0.994570410580437 0.187348114758153 no 608 0.159972622301473 758 805759 SGTC_248 streptozotocin 5.23457 mM 0.992852694491562 0.187761457207636 no 609 0.160390872984344 854 5300 DNA alkylating agent. SGTC_307 1501-1223 22.3 µM 0.99069879352221 0.188280556244063 no 610 0.160916340189722 802 2830329 SGTC_2611 pyromycin 23.93 µM 0.990457772432392 0.188338698355308 no 611 0.160975209696136 788 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1777 st045864 34.765 µM 0.98391657942738 0.189920873263084 no 612 0.162578265566653 841 4691462 SGTC_1569 carminic acid 40.6 µM 0.982344018176443 0.190302457142396 no 613 0.162965197892941 848 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1848 st056003 16.4 µM 0.982313942945753 0.190309759519787 no 614 0.162972603802614 867 146492 SGTC_703 3875-0075 71.8 µM 0.981688645318134 0.190461623087855 no 615 0.163126630498293 876 2850814 SGTC_2731 amoxapine 43.43 µM 0.977789792441142 0.191410199660725 no 616 0.164089150288911 766 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2062 5245942 200 µM 0.974921913595753 0.192109788565082 no 617 0.164799497607942 883 1376160 SGTC_1692 fluoroquinolonic acid 71 µM 0.974914858380692 0.192111511537474 no 618 0.164801247572623 807 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2591 skatole 100 µM 0.97489259005715 0.192116949804614 no 619 0.16480677105226 808 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2875 9039966 71.43 µM 0.973189727158049 0.192533094076146 no 620 0.165229507759263 823 6463691 SGTC_157 1348-1695 65.819 µM 0.972510024707999 0.192699352965957 no 621 0.165398440078051 836 5380510 SGTC_2674 ligustilide 100 µM 0.971662849368538 0.192906699403677 no 622 0.16560915225884 792 5319022 A signalling regulator. SGTC_1313 1220-0047 237 µM 0.969404325077559 0.193460139495218 no 623 0.166171747615626 865 3528706 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.968920601593802 0.19357879934119 no 624 0.166292402823338 894 16486 A toxic proline analog. SGTC_1111 tnp00062 510.699 nM 0.967976935239427 0.193810413253345 no 625 0.166527944441754 873 676306 SGTC_2256 7954252 200 µM 0.965902213689123 0.194320227520053 no 626 0.167046557273493 723 2972920 SGTC_3325 9138760 55.175 µM 0.965836661042983 0.194336348844945 no 627 0.167062960255687 807 43844959 SGTC_2383 9036125 200 µM 0.963230357505355 0.194977975252986 no 628 0.167715966850951 817 79580 SGTC_1478 0453-0656 35.7 µM 0.958761561485259 0.196081107928438 no 629 0.168839438762718 862 5258496 SGTC_1784 st039334 36.3 µM 0.958383882260916 0.196174512086322 no 630 0.16893460981827 829 3496984 SGTC_89 0302-0250 142.109 µM 0.958221341434885 0.196214718494061 no 631 0.168975578942937 905 4203518 YLR208W SEC13 SGTC_1087 pterostilbene 9.05 µM 0.958019145382765 0.196264741067078 no 632 0.169026552247105 862 5281727 Similar to reservatol, lowers cholesterol. SGTC_984 1492-0255 2.91 µM 0.953624780973655 0.197353799975346 no 633 0.170136803660792 803 1585198 SGTC_2091 4-phenylthiadiazole 200 µM 0.952019293858697 0.197752599010746 no 634 0.17054359852016 858 270010 SGTC_2635 hydroquinidine 100 µM 0.951983523774785 0.197761489753316 no 635 0.17055266895336 848 442912 An experimental heart treatment. SGTC_1197 1601-0112 267 µM 0.951207015477592 0.197954552333672 no 636 0.170749648916524 863 7350313 SGTC_3196 9111891 49.47 µM 0.951003808824796 0.198005094213792 no 637 0.170801221188819 853 18891510 SGTC_2186 6124449 200 µM 0.950542156572716 0.198119946053013 no 638 0.170918421993167 854 3834182 YLR033W RSC58 SGTC_1904 st060225 78 µM 0.948840746892196 0.198543577265391 no 639 0.171350807228134 848 66595 SGTC_1085 doxorubicin 7.67 µM 0.948189241051919 0.198705939205437 no 640 0.171516561678571 923 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_566 0958-0068 16.5 µM 0.948047420107579 0.198741293047782 no 641 0.171552656975898 790 6815365 SGTC_1627 st003713 25.6 µM 0.947448173489695 0.198890718139592 no 642 0.171705226708041 924 16195070 YER133W GLC7 SGTC_2404 5161160 200 µM 0.946921313420914 0.199022149212984 no 643 0.171839438217674 892 2831543 SGTC_2727 riluzole 51.77 µM 0.943836426964721 0.199792758037171 no 644 0.172626621375992 807 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2566 crystal violet carbinol 226 nM 0.943809512008827 0.199799489317944 no 645 0.172633499477575 720 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1568 digitonin 820 nM 0.943734577612534 0.199818230712264 no 646 0.172652649840079 902 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2737 bleomycin 30.5 nM 0.943276740891313 0.199932760484901 no 647 0.172769684791231 908 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1724 st037281 8.293 µM 0.94165793410761 0.200338028203365 no 648 0.173183899192417 838 574124 YDL195W SEC31 SGTC_3296 9122258 64.045 µM 0.940772286306317 0.200559958538994 no 649 0.173410782966367 850 4730474 SGTC_2026 5148700 152 µM 0.935944864223869 0.201772232798441 no 650 0.174650788122435 874 79838 SGTC_3161 9100388 49.47 µM 0.935267066091027 0.201942793764916 no 651 0.174825341696256 919 25236368 SGTC_1761 st044296 37 µM 0.935152880385149 0.201971535921845 no 652 0.174854758872851 855 1826700 SGTC_2274 7947094 46.08 µM 0.931879495982916 0.202796533901283 no 653 0.175699402577098 944 2971028 SGTC_1839 st053978 48 µM 0.928803532861592 0.203573607264082 no 654 0.176495456629402 872 3788398 SGTC_932 2857-0803 154 µM 0.927956409799027 0.20378792544968 no 655 0.176715090679667 928 674898 SGTC_563 tetrahydrosecaminediol 614 µM 0.927307301333698 0.203952237842791 no 656 0.176883502259653 921 334274 A psychoactive constituent of the cannabis plant. SGTC_871 0574-0004 149 µM 0.927214420616713 0.203975755703628 no 657 0.176907608510339 885 9551173 SGTC_2924 9010168 62.78 µM 0.927174766794958 0.203985796741262 no 658 0.176917900891107 871 2993929 SGTC_2680 butyl paraben 22.24 µM 0.924365377543368 0.204697932301232 no 659 0.177648057246763 863 7184 An antifungal and steroid mimetic. SGTC_475 α-linolenic acid 10 µM 0.924066762761005 0.204773713260771 no 660 0.17772577845602 934 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_147 4466-0538 29.23 µM 0.922134052143608 0.205264590198116 no 661 0.178229328462112 914 6742687 YHR072W ERG7 SGTC_1065 prochlorperazine maleate 2.48 µM 0.920214142325772 0.205752907412088 no 662 0.178730432669818 906 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2159 5658611 73.75 µM 0.919862567407656 0.20584240294203 no 663 0.178822291138226 921 793844 SGTC_952 1185-0122 232 µM 0.917541183763588 0.20643390470579 no 664 0.179429561166254 873 678600 SGTC_424 splitomicin 100 mM 0.916281687810958 0.206755252430284 no 665 0.179759585057001 817 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_343 4130-2827 29.8 µM 0.915116177240935 0.207052884402043 no 666 0.1800653215869 886 1118244 SGTC_2297 7971671 152.32 µM 0.914318831844983 0.207256645391888 no 667 0.180274669047173 876 909016 SGTC_1727 st034309 9.9045 µM 0.912699147122183 0.207670919463765 no 668 0.180700396306752 963 870305 SGTC_1732 st034308 51.822 µM 0.91195007640743 0.207862677991112 no 669 0.180897499369982 842 830119 SGTC_2445 5742597 35.57 µM 0.911132093864524 0.208072197006777 no 670 0.181112889056359 853 1774255 SGTC_3152 9099253 49.47 µM 0.910075898179682 0.208342916529383 no 671 0.181391242140538 958 25236131 SGTC_3220 9131269 49.47 µM 0.906744944676819 0.209198051933053 no 672 0.182270845007698 893 17722206 SGTC_3254 9136651 49.47 µM 0.904903698636085 0.209671629255365 no 673 0.182758203710515 957 16454030 SGTC_2688 kanamycin b 96.69 µM 0.902168336741165 0.210376340236171 no 674 0.183483725980511 1200 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3182 9108849 49.47 µM 0.901468344838725 0.210556902276773 no 675 0.183669678630271 940 17133045 SGTC_1255 0566-0045 221 µM 0.900043721322427 0.210924662906751 no 676 0.184048491976643 900 2788469 SGTC_1902 st060212 70.5 µM 0.899996144818059 0.210936951078597 no 677 0.184061151155589 956 688944 SGTC_1449 4112-4002 201 µM 0.899939136900112 0.210951675770987 no 678 0.18407632056345 849 2059539 SGTC_899 1083-0020 478 µM 0.898966097873388 0.211203096936149 no 679 0.184335359437907 925 767123 SGTC_411 enrofloxacin 100 µM 0.89882226326219 0.211240276898089 no 680 0.184373669791899 961 71188 A bacterial gyrase inhibitor. SGTC_221 trifluoperazine 10.304 µM 0.896561680892842 0.211825120813575 no 681 0.184976426551568 1029 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_161 4065-0411 162.148 µM 0.895844831688785 0.212010777274136 no 682 0.185167821067773 924 1906281 YLR208W SEC13 SGTC_124 0136-0217 7.121 µM 0.894992788922663 0.212231571187458 no 683 0.185395471385719 1027 3976905 SGTC_775 4577-0580 57.3 µM 0.894540474461035 0.21234883618916 no 684 0.185516392145352 923 2006902 SGTC_2817 7995342 71.43 µM 0.893330265648021 0.21266277557055 no 685 0.185840167338954 836 18879975 SGTC_1115 galangin 695.678 nM 0.892708287342983 0.212824227889788 no 686 0.186006705580534 1002 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1631 benzylvanillin 81.9 µM 0.889670032708579 0.213613921780674 no 687 0.186821544805887 899 75506 SGTC_1776 st049249 45.9 µM 0.88873481046774 0.213857345096441 no 688 0.187072809056763 949 1822314 SGTC_1187 1391-0724 117 µM 0.88808149959013 0.214027487201256 no 689 0.187248456712086 935 6997986 SGTC_469 w7 172 µM 0.887281935762012 0.214235825222256 no 690 0.187463564320965 908 45115570 A P450 inhibitor. SGTC_3104 9120930 49.47 µM 0.882660528843101 0.215442309718712 no 691 0.188709857164268 873 17014836 SGTC_1942 st076330 65.2 µM 0.879187146069866 0.216351674717808 no 692 0.18964990636132 964 24208414 SGTC_3051 9093778 49.47 µM 0.879067830079902 0.216382952211414 no 693 0.189682249575883 902 17217378 SGTC_1451 4152-0210 104 µM 0.877237894778944 0.216862979216191 no 694 0.190178718603702 976 659563 SGTC_574 1315-0397 40 µM 0.876711750302749 0.217001110835008 no 695 0.190321611430889 1041 6794277 SGTC_3310 9130229 44.1445 µM 0.876416347554483 0.217078686835291 no 696 0.190401867218053 920 7761258 SGTC_3146 9095609 49.47 µM 0.875534233163593 0.217310435093831 no 697 0.190641646021745 936 17173999 SGTC_416 estradiol valerate 100 µM 0.874235565445838 0.2176518797285 no 698 0.190994990642072 926 13791 A steroid. SGTC_648 0375-0473 33.3 µM 0.873430937717257 0.217863587006792 no 699 0.191214117080168 962 1713139 SGTC_1408 3909-7976 48.8 µM 0.87267276265238 0.218063180659773 no 700 0.191420733909071 980 24152374 SGTC_2388 9080168 200 µM 0.872582757063972 0.218086882111095 no 701 0.191445271189837 876 15943073 SGTC_788 1182-0090 188 µM 0.871772247944442 0.21830038287952 no 702 0.191666318611278 1035 5715185 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.86977016678991 0.218828278123557 no 703 0.192213009026896 986 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_523 1934-0222 13.7 µM 0.869062929365894 0.219014933129556 no 704 0.192406355798967 915 1361595 SGTC_2023 5144124 124 µM 0.868241041005894 0.219231961948913 no 705 0.192631195541934 930 2830192 SGTC_1432 4049-0298 68.4 µM 0.867470885583643 0.219435442254788 no 706 0.192842028639937 947 741646 SGTC_3191 9110352 49.47 µM 0.86690379513868 0.219585340749945 no 707 0.192997361970522 919 17122424 SGTC_1365 1672-3266 55.4 µM 0.866782244138048 0.219617477865872 no 708 0.193030666286225 969 6415873 SGTC_225 nsc-122657 1.016 µM 0.866760111020251 0.219623329976522 no 709 0.193036731018261 830 275685 SGTC_1978 st071761 42 µM 0.863799394275599 0.220406965611393 no 710 0.193849050336004 899 5147680 SGTC_297 0986-0032 24 µM 0.863112615087337 0.22058896946161 no 711 0.194037776321689 932 2847425 SGTC_1558 st069300 45.6 µM 0.862624440930355 0.220718393187343 no 712 0.194171993958426 894 24208000 SGTC_1578 josamycin 24.2 µM 0.861526613008895 0.221009605883676 no 713 0.194474035099435 883 5282165 A P450 substrate. SGTC_645 0845-0943 5.41 µM 0.861405550036484 0.221041732819805 no 714 0.194507360184052 922 1885106 SGTC_2032 5185112 25.99 µM 0.860151650933002 0.221374641897553 no 715 0.194852726213145 918 5718189 SGTC_2224 6650123 117.647 µM 0.85915809524745 0.22163863350513 no 716 0.195126649561287 936 2908370 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.858171053182877 0.221901072462772 no 717 0.195399008735261 927 2346 DNA damaging agent; causes G2/M arrest. SGTC_382 3229-0966 23.2 µM 0.856622553691141 0.222313151499471 no 718 0.195826758546825 995 5722370 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.855734509106982 0.222549670380858 no 719 0.196072323765465 947 5357218 A potent inhibitor of glutathione S-transferases. SGTC_188 3229-0966 278.469 µM 0.855175335004684 0.222698672560448 no 720 0.196227044345287 1080 5722370 SGTC_2734 clemastine 41.6 µM 0.854948185090383 0.222759217051459 no 721 0.196289916688621 883 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2131 toluylene red 5.2905 µM 0.854424421258391 0.222898856699391 no 722 0.196434934707919 934 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3091 9116372 49.47 µM 0.853779385686163 0.223070896871603 no 723 0.196613619246606 920 17169793 SGTC_1198 1612-1005 86.7 µM 0.849925246021856 0.22410042511317 no 724 0.197683324258994 1000 6998509 SGTC_2425 5628681 7.85 µM 0.848356191423088 0.22452032700201 no 725 0.198119816242039 1031 5714958 SGTC_2512 diallyl trisulfide 49.23 µM 0.847808847694809 0.224666909123185 no 726 0.198272217435822 964 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1915 st067105 30.6 µM 0.847682685520125 0.22470070384962 no 727 0.198307355788549 972 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1342 1486-1464 234 µM 0.847544640233937 0.224737684976522 no 728 0.19834580809954 976 3253938 SGTC_593 1203-0218 61.7 µM 0.847318710354759 0.224798217064991 no 729 0.198408750241702 1017 3666956 SGTC_1196 1588-0294 184 µM 0.846498491683175 0.225018051204606 no 730 0.19863735746458 921 6144269 SGTC_3008 9078912 71.4286 µM 0.845472049814407 0.225293328614622 no 731 0.198923665855406 957 16648731 SGTC_2206 7254556 146.969 µM 0.845386273315683 0.225316341307998 no 732 0.198947602997004 992 4398905 SGTC_2428 5615643 7.78 µM 0.845235402745207 0.22535682110425 no 733 0.19898970976889 957 2253075 SGTC_214 4373-3496 70 µM 0.844774457101065 0.225480522060905 no 734 0.199118389282938 1111 3779166 SGTC_634 1611-4317 11.2 µM 0.844663839414531 0.225510213520861 no 735 0.199149277235948 1036 2843522 SGTC_3043 9092303 49.47 µM 0.843786411813949 0.225745806737922 no 736 0.199394384976613 958 25236084 SGTC_2338 7999974 200 µM 0.843041255486961 0.225945993809109 no 737 0.199602685538129 1053 315925 SGTC_2165 5727197 32.143 µM 0.842655542336354 0.226049655484132 no 738 0.199710558980844 931 1361712 SGTC_1526 st051518 75 µM 0.842597796550165 0.226065177166919 no 739 0.19972671191953 884 673993 SGTC_1981 st071826 47 µM 0.84174368743913 0.22629482634619 no 740 0.199965719347047 920 11838600 SGTC_2857 9024691 58.44 µM 0.841667970884395 0.226315191044571 no 741 0.199986915589868 965 16478292 SGTC_2553 4-methylesculetin 85.09 µM 0.841300675370857 0.226413993408503 no 742 0.200089756195368 1020 5319502 SGTC_317 4495-0002 170 µM 0.841230920409795 0.226432760220482 no 743 0.200109290769732 929 15991618 SGTC_1445 4239-0156 97.7 µM 0.837364302534458 0.227474404528627 no 744 0.20119391243792 1068 4008346 SGTC_2818 7996756 12.99 µM 0.837332527958646 0.227482975579605 no 745 0.201202840074951 952 2241621 SGTC_2984 9022109 38.96 µM 0.836157994889706 0.227799928268619 no 746 0.201533012854807 975 6459207 SGTC_1352 1496-0991 99 µM 0.835981486611056 0.227847581241188 no 747 0.201582659108857 1004 3000039 SGTC_2592 piperlongumine 83.33 µM 0.835955443594188 0.227854612701639 no 748 0.201589984814584 934 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2429 5902844 64.44 µM 0.835524469270218 0.227970990946558 no 749 0.201711237823129 1022 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1735 st034310 56.75 µM 0.835156382171082 0.228070413894883 no 750 0.201814832323611 961 871153 SGTC_3022 9087993 49.47 µM 0.83460119081499 0.228220421154638 no 751 0.201971145730268 1000 17173644 SGTC_2144 5628481 200 µM 0.832097198426383 0.228897664108044 no 752 0.202677041533711 976 2818399 SGTC_3337 9144342 33.5465 µM 0.830515858867834 0.229325941919452 no 753 0.203123592594216 998 17682949 SGTC_812 4251-0442 148 µM 0.830096731257234 0.229439530475031 no 754 0.203242047533158 1011 5723007 SGTC_1091 telmisartan 47.6 µM 0.830000464083667 0.229465624473492 no 755 0.203269260634202 1042 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1401 3807-4679 7.6 µM 0.828486833125067 0.229876125006697 no 756 0.203697424323592 973 3291456 SGTC_359 0081-0058 15.9 µM 0.828100433579839 0.22998098336924 no 757 0.203806811998048 940 3494159 SGTC_2868 9035608 32.47 µM 0.826809942116176 0.230331381700377 no 758 0.204172396996242 1028 6462614 SGTC_2271 7849410 118.62 µM 0.825465268879171 0.23069680900839 no 759 0.204553746423726 1015 972430 SGTC_980 1473-0395 201 µM 0.824413947155198 0.230982740806226 no 760 0.204852196362637 942 768876 SGTC_1782 st039423 80.636 µM 0.823761437974722 0.231160305556332 no 761 0.205037561279794 939 2068169 SGTC_1682 st012968 530 nM 0.822424727507154 0.231524297029597 no 762 0.205417605392179 925 24207270 SGTC_2044 5102272 200 µM 0.821424183934106 0.231796957902123 no 763 0.205702346465357 941 592666 SGTC_2216 7189485 200 µM 0.820609788601647 0.232019023000712 no 764 0.205934285122174 1029 731273 SGTC_322 k048-0136 19.3 µM 0.819297927558425 0.232376983415803 no 765 0.206308227355944 993 6823282 SGTC_1148 3909-7663 27.7 µM 0.819270744385357 0.232384403988221 no 766 0.206315980094941 1050 4084526 SGTC_2020 4017018 200 µM 0.818541339539816 0.23258356908316 no 767 0.206524073455586 1021 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_423 5-fluorouracil 457 µM 0.81795470731479 0.232743818727981 no 768 0.206691525103167 955 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2544 sphondin 68.51 µM 0.817483763592886 0.232872510267371 no 769 0.206826012123353 994 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1685 st024049 53.0905 µM 0.817368658232367 0.232903970325237 no 770 0.206858890544448 988 1941139 SGTC_3280 9140961 49.47 µM 0.817301087146458 0.232922439637593 no 771 0.20687819282955 962 4901226 SGTC_1049 3226-0134 66 µM 0.816720614654087 0.233081134616159 no 772 0.207044053899646 1033 5702385 SGTC_1294 1000-1494 117 µM 0.816341421185302 0.233184834469438 no 773 0.207152445062235 994 712797 YDL207W GLE1 SGTC_2693 st077581 40.7 µM 0.815235303700395 0.233487475978167 no 774 0.207468816679009 1060 25238761 SGTC_1003 4049-0218 100 µM 0.814435802872317 0.233706360593692 no 775 0.207697667541618 1029 295161 SGTC_3226 9131256 49.47 µM 0.814191355167843 0.233773307353625 no 776 0.207767668544013 929 17178073 SGTC_2107 5363541 170.161 µM 0.812629441728119 0.23420131857533 no 777 0.208215273078388 1039 244052 SGTC_37 0566-0070 1.56 µM 0.812086114017722 0.234350308343511 no 778 0.208371110226417 1067 1626686 SGTC_2117 5521686 200 µM 0.811071366125393 0.234628710018699 no 779 0.208662344179067 998 803312 SGTC_879 0831-1030 162 µM 0.810912530926104 0.234672303880159 no 780 0.208707951793164 1018 1549252 SGTC_1384 3089-0840 101 µM 0.809144185471793 0.235157945831748 no 781 0.209216107580358 980 1069836 SGTC_1540 guanosine 70.6 µM 0.808684905739619 0.235284168883903 no 782 0.209348206304793 984 6802 Guanosine is a purine nucleoside SGTC_1235 benzylparaben 21.5 µM 0.808440133683579 0.235351454439906 no 783 0.209418628056303 970 7180 SGTC_1443 4112-3303 14 µM 0.807786797844084 0.235531102370587 no 784 0.209606663236374 1059 704433 SGTC_2077 5212015 200 µM 0.807164967911198 0.235702157363532 no 785 0.209785722967932 980 780900 SGTC_2034 5197015 53.07 µM 0.803585656186355 0.236688096956002 no 786 0.210818154890272 1010 780676 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.803212453916376 0.236791027855181 no 787 0.210925974224519 1131 5282309 SGTC_2696 st077691 74.316 µM 0.802343968737449 0.237030655320831 no 788 0.211177007511484 962 757133 SGTC_1917 st066507 28.5 µM 0.801763410767867 0.237190913847319 no 789 0.211344913806962 1023 3156428 SGTC_3128 9127691 49.47 µM 0.80157731872354 0.23724229570807 no 790 0.21139875103467 930 41316314 SGTC_1725 st036284 20.55 µM 0.800628716583074 0.237504309164669 no 791 0.211673310508752 1079 707914 SGTC_226 1,3-diallylurea 8.28947 mM 0.799197827688202 0.237899835387959 no 792 0.212087855681339 1011 74537 YKL182W FAS1 SGTC_1596 piperlongumine 63 µM 0.799092681514037 0.237928914125421 no 793 0.21211833646419 1071 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1508 1080-0625 72.9 µM 0.798699381383364 0.238037700658029 no 794 0.212232372789604 990 767111 SGTC_1100 amiodarone 5.07 µM 0.797903898518149 0.238257813957113 no 795 0.212463130436227 1084 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2168 5727979 200 µM 0.796722217231366 0.238584995641854 no 796 0.212806188910699 1000 695210 SGTC_2653 dihydrofissinolide 100 µM 0.794961100602116 0.239073066300866 no 797 0.213318065101868 1068 6857746 SGTC_3004 9076122 71.4286 µM 0.794042307103225 0.239327914495096 no 798 0.213585401122195 1044 44782551 SGTC_2720 fluspirilene 36.88 µM 0.793634688447119 0.23944102426881 no 799 0.213704066045982 997 3396 An atypical antipsychotic. SGTC_287 k060-0039 29.6 µM 0.79275379610309 0.239685562058095 no 800 0.213960640354073 1074 5861974 SGTC_929 2805-0021 398 µM 0.792136698286924 0.239856951014546 no 801 0.214140486955355 1027 3098024 SGTC_1056 3448-1962 115 µM 0.791177944214552 0.240123362042957 no 802 0.214420080073155 1003 715507 SGTC_1213 1315-0166 115 µM 0.790075982627557 0.240429765576938 no 803 0.214741697615128 947 768401 SGTC_3206 9114350 49.47 µM 0.789997713406196 0.240451536651947 no 804 0.214764551858273 967 17087243 SGTC_115 0527-0192 112.043 µM 0.789136582440539 0.240691136506864 no 805 0.215016091328439 1090 4233931 SGTC_3178 9107506 49.47 µM 0.788942441090308 0.240745172064988 no 806 0.215072824342159 1029 8897194 SGTC_546 peri-Naphthalide 147 µM 0.788042623813632 0.240995705302209 no 807 0.215335887180834 1034 223824 A penicillin ester. SGTC_3005 9076496 71.4286 µM 0.785241412596095 0.241776544507663 no 808 0.216156019498364 1036 21368410 SGTC_84 0443-0269 128.823 µM 0.784580632729142 0.241960937204301 no 809 0.2163497444847 1045 6150058 SGTC_90 0870-0863 4.608 µM 0.784252114962981 0.242052639500174 no 810 0.216446095493063 1067 1738164 SGTC_641 4092-0595 30 µM 0.783032205668921 0.242393329288977 no 811 0.216804100048494 1067 786260 SGTC_2533 agelasine 13.65 µM 0.78289502371198 0.242431656981275 no 812 0.216844379991503 1096 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3067 9117431 49.47 µM 0.778884104785504 0.243553730055734 no 813 0.218023994058653 1065 17150885 SGTC_1129 3453-1384 223 µM 0.778601667627533 0.243632848730853 no 814 0.218107198214799 1074 1084452 SGTC_880 0833-0487 87.2 µM 0.778024131175554 0.243794676301687 no 815 0.218277393674128 1063 76075 SGTC_1505 k297-0037 20.6 µM 0.777154067627892 0.244038580405726 no 816 0.218533938985836 1058 4089396 SGTC_370 0180-0345 38.7 µM 0.77708576640326 0.244057732794607 no 817 0.218554085504061 998 3989527 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.775158900820009 0.244598380275798 no 818 0.219122885219659 1145 5024745 SGTC_979 1426-2828 121 µM 0.774027440662479 0.244916150129862 no 819 0.219457282051749 1116 747872 SGTC_1236 0330-0013 258 µM 0.773798529780981 0.244980466610852 no 820 0.219524971044333 1040 4617066 SGTC_2655 perillic acid 100 µM 0.771762377175149 0.245552958678341 no 821 0.220127589294041 1074 5702197 An apoptosis inducer. SGTC_380 3970-0968 6 µM 0.770701421935542 0.245851545259739 no 822 0.220441964462618 1042 2891601 SGTC_3302 9125395 16.351 µM 0.770661646848523 0.245862743024193 no 823 0.220453755352802 1048 17599668 SGTC_2790 5423970 71.43 µM 0.770415081079432 0.245932164075059 no 824 0.220526855146914 1105 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2135 5326629 150.42 µM 0.770319497093066 0.24595907875314 no 825 0.220555196837494 1046 5020077 SGTC_1413 3910-0535 34.4 µM 0.768425770557112 0.246492642731413 no 826 0.22111713744286 1093 2876951 SGTC_2715 st079500 56.4 µM 0.768106172833663 0.246582751616601 no 827 0.221212054958133 1028 28246688 SGTC_601 0986-0029 62.9 µM 0.767754260891389 0.246681991732628 no 828 0.221316596449168 1071 24747981 SGTC_1846 st056244 14.8 µM 0.767547982171635 0.246740172829229 no 829 0.221377888221038 1085 5393182 SGTC_1043 0916-0009 19.3 µM 0.766099430678793 0.247148944944826 no 830 0.221808570866764 1162 3101130 SGTC_2842 9000675 19.48 µM 0.765668764094657 0.247270546157249 no 831 0.221936708691749 1079 2989072 SGTC_3341 9147222 25.867 µM 0.76498983778615 0.247462309890009 no 832 0.222138797972086 1040 1939759 SGTC_771 0250-0039 27.3 µM 0.764769395189548 0.247524591311722 no 833 0.22220443752009 1046 3005115 SGTC_1044 1222-0021 1.78 µM 0.764270453058544 0.247665587846259 no 834 0.222353044666749 1030 4306703 SGTC_1288 0973-0013 65.5 µM 0.764021107610015 0.247736066686664 no 835 0.222427332066959 1115 4315430 SGTC_1920 st075728 45.7 µM 0.762530979891245 0.248157482500124 no 836 0.222871580251856 1066 3400306 SGTC_1555 citronellol 128 µM 0.762421607568847 0.248188428611887 no 837 0.222904207059825 1071 8842 A terpine precursor. SGTC_3344 9148862 3.898 µM 0.761810638863151 0.248361335664452 no 838 0.223086514903568 1106 4905352 SGTC_2761 levamisole 97.89 µM 0.760835251015609 0.24863750809788 no 839 0.223377738201902 1080 26879 An alkaline phosphatase inhibitor. SGTC_2497 7-hydroxyflavone 100 µM 0.759154592646847 0.249113755118795 no 840 0.223880042525477 1023 5281894 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.758508654421449 0.249296923199231 no 841 0.224073267004327 1092 364106 SGTC_691 1548-0686 185 µM 0.756357438204771 0.249907457484022 no 842 0.224717459519562 1101 46495133 SGTC_265 mycophenolic acid 32.932 µM 0.755283249123675 0.250212618711391 no 843 0.22503952360955 1171 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1704 st028805 70.8 µM 0.752642661398226 0.250963609779705 no 844 0.225832337153933 1097 2876101 SGTC_949 1165-0505 146 µM 0.752067951024298 0.25112721705067 no 845 0.226005098030817 1126 6244267 SGTC_1527 coumarin 137 µM 0.750906432411406 0.251458047744548 no 846 0.226354484447082 1072 323 A hepatotoxic, DNA x-linker. SGTC_906 1165-0455 526 µM 0.750731094683146 0.251508008488393 no 847 0.226407252769068 1119 3252859 SGTC_1484 3473-2379 286 µM 0.749982000517571 0.251721514487719 no 848 0.226632772731373 1240 671917 SGTC_2917 7979103 53.79 µM 0.749820716045898 0.251767496130328 no 849 0.226681345116074 1116 2980565 SGTC_1998 st075797 76.8 µM 0.7492943590296 0.251917589536417 no 850 0.226839903508415 1140 24208315 SGTC_2244 6635614 200 µM 0.749183099862966 0.251949321704311 no 851 0.226873426933277 968 836499 SGTC_144 4161-2749 112.381 µM 0.748824490353228 0.252051614887483 no 852 0.226981498342138 1016 797501 YMR168C CEP3 SGTC_2409 alverine citrate 63.97 µM 0.745895588024661 0.252887902437559 no 853 0.227865245317628 1103 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2254 7938975 95.19 µM 0.743415139170606 0.253597283865982 no 854 0.228615190684453 1147 2969277 SGTC_1502 4534-4282 27.7 µM 0.743202589018804 0.253658119486244 no 855 0.228679518067292 1084 3278949 SGTC_150 3970-0969 77.2 µM 0.742109583104736 0.253971078157412 no 856 0.22901047204065 1113 6615640 SGTC_295 k015-0027 31 µM 0.741963568994495 0.254012901484833 no 857 0.229054704353804 1108 3887424 SGTC_3276 9139060 49.47 µM 0.74180095731432 0.254059483164442 no 858 0.229103970238546 1186 4870619 SGTC_5 0352-0601 109.883 µM 0.740979279624997 0.254294929155335 no 859 0.229353001892565 1070 762456 SGTC_1913 st060213 96.1 µM 0.740432872545956 0.254451561581983 no 860 0.229518689308978 1145 688959 SGTC_2403 6032726 181.2 µM 0.737221572356255 0.255373129890548 no 861 0.230493808408584 1131 2881040 SGTC_3217 9129673 49.47 µM 0.737056050158034 0.255420678133209 no 862 0.230544132301208 1113 17248312 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.736668055745814 0.255532152325194 no 863 0.230662118724313 1042 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1620 st003704 16.5 µM 0.735654825591998 0.255823382024306 no 864 0.230970394048229 1122 2834414 SGTC_2030 5175110 200 µM 0.735222265893445 0.255947764106309 no 865 0.231102070380622 1160 2831986 SGTC_1062 mesoridazine 14.2 µM 0.733396580491656 0.256473085444193 no 866 0.231658292103237 1150 4078 A neuroleptic. SGTC_3230 9131665 49.47 µM 0.733352057639023 0.256485903429025 no 867 0.231671865952868 1083 15943720 SGTC_460 trequinsin 123 µM 0.733346910499701 0.256487385295259 no 868 0.231673435209184 1183 5537 A vasodilator. SGTC_1265 0819-1001 68.8 µM 0.730070221402252 0.2574316516081 no 869 0.232673631265685 1140 3106768 SGTC_2111 5486399 200 µM 0.72840842166022 0.257911233365435 no 870 0.233181804750532 1176 689674 SGTC_502 l-744,832 89.3 µM 0.72785918737084 0.258069839728427 no 871 0.233349894346964 1126 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3169 9102970 49.47 µM 0.72627144291373 0.258528628498167 no 872 0.23383619114774 1200 17027839 SGTC_46 0329-0187a 2.197 µM 0.724560404335956 0.259023516349467 no 873 0.23436087877952 1171 46494817 SGTC_2665 lovastatin 100 µM 0.723844165279091 0.25923082128314 no 874 0.234580705801094 1158 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3208 9114115 49.47 µM 0.723102984918025 0.25944543535979 no 875 0.23480830779138 1115 650895 SGTC_1323 1348-1351 11.2 µM 0.722299584571233 0.259678169288399 no 876 0.235055154130458 1097 6989654 SGTC_3193 9111931 49.47 µM 0.721316269314003 0.259963168661221 no 877 0.235357474682126 1188 17087244 SGTC_2373 9071805 200 µM 0.720149399054137 0.260301577911263 no 878 0.235716507565859 1167 10149009 SGTC_930 2810-3379 265 µM 0.719687013754664 0.260435739097279 no 879 0.235858861845232 1200 1015764 SGTC_355 1311-2252 105 µM 0.718375272159005 0.260816534907845 no 880 0.236262964739968 1141 5338538 SGTC_406 estrone 100 µM 0.716854663341879 0.261258322635428 no 881 0.236731889284821 1159 5870 A steroid. SGTC_1629 st005085 44.9 µM 0.716121589942723 0.261471442251906 no 882 0.236958136815916 1170 24207091 SGTC_2874 9043904 71.43 µM 0.714800428578388 0.261855756495283 no 883 0.237366185158308 1080 4463428 SGTC_2621 lithochol-11-enic acid 100 µM 0.714393405410557 0.26197421430996 no 884 0.237491974321042 1165 6708711 SGTC_953 1188-0045 9.7 µM 0.713815264668375 0.262142520470371 no 885 0.237670709684761 1167 6144426 SGTC_818 4072-2707 53.5 µM 0.712941908147376 0.262396873771362 no 886 0.23794085251119 1145 882871 SGTC_1326 1431-2094 10.8 µM 0.711485674990137 0.262821262876376 no 887 0.238391662316216 1156 616278 SGTC_3077 9117319 49.47 µM 0.71105201853503 0.262947710898859 no 888 0.238526000773927 1199 17154678 SGTC_1838 st055369 84.5 µM 0.709866274091254 0.263293615734428 no 889 0.238893533151646 1165 676036 SGTC_1131 3454-3128 32.3 µM 0.709098083191058 0.263517836015033 no 890 0.239131806191861 1204 710982 SGTC_1847 st056231 15 µM 0.709062116472374 0.263528336402212 no 891 0.239142965324156 1207 5393180 SGTC_190 3970-0790 3.722 µM 0.708398026450903 0.263722254066847 no 892 0.239349058837765 1156 2832352 SGTC_993 3909-8757 62.7 µM 0.706095234171851 0.264395244405338 no 893 0.240064457644077 1119 4288324 YLR208W SEC13 SGTC_680 0417-1641 114 µM 0.703745169465829 0.265082950236147 no 894 0.240795742633948 1160 2835990 SGTC_34 0469-0683 81.75 µM 0.70106084853334 0.265869580517616 no 895 0.241632521121149 1188 3690923 SGTC_1173 0443-0020 122 µM 0.700972997101043 0.265895345030384 no 896 0.241659933541879 1185 5331295 SGTC_2652 actinonin 100 µM 0.700409244560259 0.26606070891505 no 897 0.241835882305064 1170 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.700302040879066 0.266092160550552 no 898 0.24186934874156 1200 688664 SGTC_2998 9066762 71.4286 µM 0.699125953226575 0.266437327141012 no 899 0.242236660240371 1227 4945196 SGTC_1633 st005664 67.9 µM 0.698858692267371 0.266515796366173 no 900 0.242320172370141 1217 2063822 SGTC_946 3434-1334 87.4 µM 0.697547869351674 0.266900830052436 no 901 0.242729996418946 1156 4047976 SGTC_1690 st023502 41.2 µM 0.695518299687824 0.267497538195023 no 902 0.243365273512065 1162 24207482 SGTC_211 3455-0679 143.504 µM 0.695417307009917 0.267527248332775 no 903 0.243396908754057 1219 748649 SGTC_2073 5212005 126 µM 0.695143355682846 0.267607848014448 no 904 0.243482733256998 1077 691789 SGTC_1314 1222-0010 41.1 µM 0.694598595646686 0.267768159146898 no 905 0.243653446297485 1201 3526027 SGTC_1480 1070-0044 41.2 µM 0.692551645808482 0.268370964523699 no 906 0.244295482204773 1189 3124987 SGTC_499 genistein 192 µM 0.692327651808394 0.268436969824768 no 907 0.244365794339561 1215 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1513 0337-0559 19 µM 0.692310307495723 0.268442081090447 no 908 0.244371239206586 1138 775073 SGTC_417 st075190 100 µM 0.688282516393638 0.269630370734936 no 909 0.245637444736978 1215 222757 SGTC_1465 k213-0056 144 µM 0.685024377451006 0.270593519760166 no 910 0.246664269114325 1135 24048857 YMR208W ERG12 SGTC_2407 paclitaxel 400 µM 0.681570138600425 0.271616511822062 no 911 0.24775540119082 1249 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1370 2001-0092 44.6 µM 0.681306542155476 0.271694656386195 no 912 0.247838772286555 1298 790957 SGTC_1900 st060200 72.8 µM 0.681228943742029 0.271717662979472 no 913 0.247863318204852 1236 688945 SGTC_1391 3442-0225 151 µM 0.68016603406708 0.272032894971224 no 914 0.248199668213014 1183 5227075 SGTC_1116 jasmonic acid  1.58368 µM 0.679965986718353 0.272092244257927 no 915 0.248262998941838 1259 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1042 0350-0096 82 µM 0.679805869828273 0.272139751765884 no 916 0.248313694745542 1225 3122515 SGTC_3030 9087619 49.47 µM 0.67903775872687 0.272367711615669 no 917 0.248556968857094 1198 25236973 SGTC_2040 5100729 123 µM 0.678098941517877 0.272646462345709 no 918 0.248854480910179 1224 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2763 lisinopril 49.32 µM 0.678015718040172 0.272671179636236 no 919 0.248880863652261 1196 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1660 st012960 28.1 µM 0.6764956660417 0.273122829125044 no 920 0.249362998383921 1208 24207266 SGTC_180 1486-1293 102.781 µM 0.675921172448939 0.273293623547148 no 921 0.249545347212044 1249 4140536 SGTC_2156 5649887 115 µM 0.675918261168907 0.273294489192617 no 922 0.249546271455828 1274 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3290 9121031 71.43 µM 0.675327658808964 0.273470128085397 no 923 0.249733807531784 1201 17014854 SGTC_1530 rhein 70.4 µM 0.674949844083938 0.273582515486265 no 924 0.249853815630131 1264 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1951 sophoraflavanone G 9.2 µM 0.674229244055621 0.273796933541781 no 925 0.250082790020794 1246 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_983 1491-0821 12.2 µM 0.672330844580456 0.274362209124351 no 926 0.25068654883522 1203 46495113 SGTC_1870 st057514 26.5 µM 0.669612186208669 0.27517273049158 no 927 0.251552521810915 1239 5393161 SGTC_1912 st060209 90.8 µM 0.669339474386025 0.275254099862113 no 928 0.251639475717105 1214 688787 SGTC_1040 k898-0338 155 µM 0.668180133966222 0.275600145870248 no 929 0.252009307446497 1279 20969351 SGTC_418 lividomycin a 100 µM 0.667239967724907 0.27588092860948 no 930 0.252309432670971 1251 72394 An antibiotic. SGTC_1652 st011932 78 µM 0.666239154073566 0.276179978175853 no 931 0.252629125051333 1211 1551076 SGTC_1415 3966-0071 78.1 µM 0.665817577533569 0.276305995569453 no 932 0.252763854127814 1238 2893185 SGTC_1953 st076800 12.1 µM 0.665545012638466 0.27638748550884 no 933 0.252850981614013 1213 297591 SGTC_2139 5578692 56.4705 µM 0.663569393975766 0.276978497137993 no 934 0.253482975748341 1200 650991 YMR113W FOL3 SGTC_1466 k213-0079 57.5 µM 0.661808904581482 0.277505673043264 no 935 0.254046849315349 1223 3657981 SGTC_1504 k297-0033 30 µM 0.661705809508305 0.277536559900899 no 936 0.254079890396473 1152 4388117 SGTC_2438 5259590 200 µM 0.659831577935982 0.278098364627267 no 937 0.254680958218826 1255 1201127 SGTC_480 am 92016 50 µM 0.658468588449439 0.278507271597196 no 938 0.255118537421954 1185 2129 K+ channel blocker. SGTC_1113 artemisinin 1.17947 µM 0.658230651551518 0.278578684451152 no 939 0.255194965860418 1265 2240 An anti-malaria and mitochondrial poison. SGTC_2723 salbutamol 83.58 µM 0.65731519113673 0.27885352800324 no 940 0.255489135310826 1247 9884233 β2-adrenoceptor agonist SGTC_357 1325-0123 420 µM 0.654520020606172 0.279693521957939 no 941 0.256388416463489 1249 1098503 SGTC_2031 5180455 200 µM 0.654186410435942 0.279793859175033 no 942 0.256495857860532 1226 29949 SGTC_942 3253-1115 227 µM 0.651705534657648 0.280540559267301 no 943 0.257295575737258 1309 46497897 SGTC_55 0767-0285 6.563 µM 0.649537049144539 0.281194024249697 no 944 0.257995653629661 1235 3116166 SGTC_2773 thioridazine 9.09 µM 0.649423654207512 0.281228215602632 no 945 0.258032289427527 1275 5452 An antipsychotic. SGTC_1069 diphenylcyclopropenone 8.49 µM 0.649203110572878 0.281294720662631 no 946 0.258103550705656 1313 65057 A dermal irritant. YDR527W RBA50 SGTC_3227 9130768 49.47 µM 0.648712923146987 0.281442564148297 no 947 0.258261974871036 1293 17720899 SGTC_2261 9010538 184.68 µM 0.648364716833905 0.281547608045068 no 948 0.258374542627626 1200 6457250 SGTC_1521 st012942 49.4 µM 0.643686034329145 0.282960863967329 no 949 0.259889523929123 1327 24207259 SGTC_1520 flindersine 88 µM 0.643488483518981 0.283020611579798 no 950 0.259953592568814 1391 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2768 sulfasalazine 50.2 µM 0.642497906085822 0.283320294828964 no 951 0.260274974218729 1349 5384001 An antioxidant and salicylic acid derivative. SGTC_2690 usnic acid 100 µM 0.638350918175116 0.284576548516243 no 952 0.26162263670006 1362 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2337 9009472 200 µM 0.637391726826605 0.284867496221223 no 953 0.261934857964143 1339 5742383 SGTC_1512 0259-0544 12.2 µM 0.635702495597897 0.285380228777707 no 954 0.26248517475393 1280 18476 SGTC_2100 5377183 190 µM 0.635079556816426 0.285569420324328 no 955 0.262688264672366 1311 2844202 SGTC_66 0109-0187 42.4 µM 0.634981163047083 0.285599308766212 no 956 0.262720350267186 1292 759417 SGTC_1833 st055984 71 µM 0.632503771990105 0.286352340082594 no 957 0.263528872233994 1300 676288 SGTC_2979 9012552 45.46 µM 0.632029669582769 0.286496556298575 no 958 0.263683745044962 1343 17100905 SGTC_860 0443-0016 25.1 µM 0.629383782874473 0.287302035182371 no 959 0.264548916180072 1300 5337942 SGTC_1234 0326-0494 15.5 µM 0.627674387022815 0.2878229902477 no 960 0.265108633724635 1351 1547813 SGTC_2079 5212404 121 µM 0.627552619556295 0.287860117088694 no 961 0.265148527700254 1322 758462 SGTC_1887 st057648 70.8 µM 0.626402184134093 0.288210995864881 no 962 0.265525588663204 1301 688672 SGTC_356 1634-0012 32.5 µM 0.624702402733808 0.288729792184616 no 963 0.266083197937212 1305 735457 SGTC_1448 4255-0083 152 µM 0.624158683570308 0.288895835420656 no 964 0.266261688829739 1386 5399660 SGTC_1278 0874-0585 172 µM 0.623054473748399 0.289233181871511 no 965 0.266624362742334 1298 766306 SGTC_3035 9091303 49.47 µM 0.622848522774554 0.289296122307838 no 966 0.266692034256826 1322 25237002 SGTC_2846 9008642 19.48 µM 0.622545300656185 0.289388801378211 no 967 0.266791682990954 1301 2992898 SGTC_543 3844-1095 191 µM 0.62061950533453 0.289977741201695 no 968 0.267425001421579 1336 4230703 SGTC_1933 st074711 15.9 µM 0.620004331339848 0.290165989865934 no 969 0.267627467663291 1280 17250958 SGTC_1728 st035614 33.7865 µM 0.618605816909384 0.290594160529126 no 970 0.268088034442734 1366 15945546 SGTC_413 propylparaben 100 µM 0.618426884999726 0.290648963835489 no 971 0.268146990098744 1276 7175 A pharmaceutical preservative. SGTC_1369 1866-0067 208 µM 0.6162489680961 0.291316403949544 no 972 0.268865107047357 1342 3531355 SGTC_1798 st045719 60.953 µM 0.614904130745741 0.291728897039502 no 973 0.269309017354691 1257 3980186 SGTC_819 1013-0258 27.7 µM 0.611441237308043 0.29279229836958 no 974 0.270453754768811 1319 5753198 SGTC_2661 dactinomycin 12.96 µM 0.61128858615114 0.292839216581596 no 975 0.270504272947043 1325 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2511 berberine 10.47 µM 0.609081855154012 0.293517857630848 no 976 0.271235091966944 1329 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_464 bw-b 70c 158 µM 0.608297571050664 0.293759225630755 no 977 0.271495065855845 1355 5353454 SGTC_1828 st055811 49 µM 0.608054189094175 0.293834146513667 no 978 0.271575767145935 1293 5877589 SGTC_1964 st076914 61 µM 0.607079643327497 0.294134231923563 no 979 0.271899029470869 1319 24208661 SGTC_2749 bexarotene 57.39 µM 0.605701265373425 0.294558908339372 no 980 0.272356571806078 1304 82146 An retinoic acid receptor inhibitor. SGTC_325 2810-4341 181 µM 0.601051332860247 0.295993629166352 no 981 0.273902898310512 1356 774970 SGTC_636 0kpi-0074 126 µM 0.600103159559412 0.296286578122847 no 982 0.274218743510736 1313 616434 SGTC_271 rotenone 740 µM 0.598825671319939 0.296681482796111 no 983 0.274644570760349 1365 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_15 0266-0086 27.098 µM 0.5976258846961 0.297052587228777 no 984 0.275044794361597 1416 1712902 YIL048W NEO1 SGTC_967 1306-0166 352 µM 0.596903300627271 0.297276191141364 no 985 0.275285971753191 1350 4437607 SGTC_944 3370-0224 231 µM 0.596901141881405 0.297276859281308 no 986 0.275286692435238 1326 4580514 SGTC_448 monastrol 171 µM 0.596240897846347 0.297481239478023 no 987 0.275507153803959 1320 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3038 9091290 49.47 µM 0.595013415371744 0.297861380180626 no 988 0.27591725180321 1387 25236843 SGTC_989 1501-0895 10.3 µM 0.590261660334075 0.299335041678659 no 989 0.277507619526825 1362 2830112 SGTC_773 4358-1457 44.6 µM 0.589816850915767 0.299473159506619 no 990 0.277656722060805 1377 1186886 SGTC_950 1165-0508 94.1 µM 0.589601521611075 0.299540031812558 no 991 0.277728915668755 1327 6148369 SGTC_1214 0358-0031 63.7 µM 0.58956528518155 0.2995512860023 no 992 0.277741065583164 1541 4301366 SGTC_509 pifithrin 175 µM 0.588605590682404 0.29984941444504 no 993 0.278062941338762 1434 4817 A p53 inhibitor. SGTC_3234 9132280 49.47 µM 0.587725296021254 0.300122995438368 no 994 0.278358346796282 1346 17612295 SGTC_3339 9145883 14.936 µM 0.587459561572382 0.300205603479087 no 995 0.278447550854235 1316 2030670 SGTC_1756 st041558 35.5 µM 0.586400389339236 0.300534967153306 no 996 0.27880324136751 1456 3955792 SGTC_1762 st045503 25.4615 µM 0.585720442533109 0.300746491608251 no 997 0.279031697135808 1370 4645554 SGTC_1619 st003326 88.7 µM 0.585317319598871 0.300871930716978 no 998 0.279167185646593 1404 2849032 SGTC_1496 4469-0713 57.4 µM 0.584939956995439 0.300989375404473 no 999 0.279294045154762 1383 746691 SGTC_707 0865-0008 204 µM 0.580825606193296 0.30227120308445 no 1000 0.280678997720504 1416 723043 SGTC_363 0455-0021 3.06 µM 0.580396395248766 0.302405064908555 no 1001 0.280823667737612 1390 4597466 SGTC_1751 st044839 27.194 µM 0.575775684009435 0.303847847461199 no 1002 0.28238340561685 1376 5291326 SGTC_2733 amorolfine 100 µM 0.575652486967038 0.30388635681134 no 1003 0.282425048194979 1418 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_519 k048-0011 62.8 µM 0.574039506191631 0.304390748501008 no 1004 0.282970533896831 1399 6836379 SGTC_1991 st073000 8.92 µM 0.573654028052631 0.304511345680459 no 1005 0.283100971619222 1423 4301969 YIL048W NEO1 SGTC_2864 9034755 47.6 µM 0.571768849098504 0.305101431553732 no 1006 0.283739291924085 1367 4930451 SGTC_2713 st079149 53.4 µM 0.571352282590479 0.305231890817442 no 1007 0.283880433977423 1394 3103253 SGTC_2008 4012253 172 µM 0.570956263810499 0.305355937941996 no 1008 0.284014645152759 1386 603940 SGTC_1153 4055-0057 267 µM 0.569743035001404 0.305736103326511 no 1009 0.284425998506269 1346 882706 SGTC_409 arachidonic acid 100 µM 0.569109469811159 0.305934714332475 no 1010 0.284640926106086 1395 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3192 9110362 49.47 µM 0.567589704457636 0.306411365340752 no 1011 0.285156799824765 1460 16649480 SGTC_1163 k060-0048 49.9 µM 0.567317767353759 0.306496688819467 no 1012 0.285249153952041 1385 6809982 SGTC_3189 9110682 49.47 µM 0.567081618266877 0.306570791896118 no 1013 0.285329365464313 1421 17122418 SGTC_2563 tomatine 8.54 µM 0.567067524386274 0.306575214775725 no 1014 0.285334152997974 1437 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2080 5212524 12.4 µM 0.566930603094963 0.306618184279147 no 1015 0.285380665621148 1398 260183 SGTC_982 1491-0518 27.5 µM 0.566590055943723 0.306725068461452 no 1016 0.285496366290618 1359 3091256 SGTC_2972 9093619 59.92 µM 0.566223201649156 0.306840227798238 no 1017 0.285621029774755 1337 25236256 SGTC_890 0929-0006 47.2 µM 0.565194718375213 0.307163180896759 no 1018 0.285970664360895 1345 1378169 SGTC_2732 terfenadine 20 µM 0.563531802665193 0.307685668039461 no 1019 0.286536405281393 1392 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2191 5911152 200 µM 0.562612053276395 0.307974820468489 no 1020 0.286849541304308 1394 2875902 SGTC_1518 st038567 90.8 µM 0.561775309889764 0.308237980934212 no 1021 0.287134558072831 1361 77966 SGTC_2234 tolnaftate 200 µM 0.56155506878727 0.308307264386618 no 1022 0.28720960025915 1383 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2430 5571206 200 µM 0.560903230192362 0.308512359798481 no 1023 0.287431753929903 1430 1731771 SGTC_170 4197-0004 226 µM 0.560284178008459 0.308707194582209 no 1024 0.287642808848643 1435 218692 SGTC_506 n9-isopropylolomoucine 153 µM 0.559807522946313 0.308857249311545 no 1025 0.287805365875079 1440 6610355 SGTC_3323 9138564 53.9225 µM 0.558517108060293 0.309263642057588 no 1026 0.288245662758437 1478 43912313 YNL103W MET4 SGTC_1653 st012112 65 µM 0.55608431751374 0.310030439965452 no 1027 0.289076607673453 1414 720429 SGTC_3256 9138902 49.47 µM 0.55259670686422 0.311131151615281 no 1028 0.290269798741722 1452 17228773 SGTC_216 k038-0035 28.382 µM 0.55244962539617 0.311177608677439 no 1029 0.290320169316927 1371 4444231 YPR107C YTH1 SGTC_508 roscovitine 141 µM 0.551744046887163 0.311400514091423 no 1030 0.290561863698168 1467 160355 A CDKinase inhibitor. SGTC_86 0417-1630 471.922 µM 0.550773773696588 0.31170715442716 no 1031 0.290894382337948 1426 3634867 SGTC_1096 rimcazole 32.2 µM 0.54927784049588 0.312180177610084 no 1032 0.291407396121397 1373 18528119 A dopamine reuptake inhibitor. SGTC_2798 7813637 45.45 µM 0.548982161594467 0.312273709770349 no 1033 0.2915088458771 1458 956368 SGTC_1842 st055362 61.2 µM 0.547014703768747 0.31289638392983 no 1034 0.292184315210114 1464 676032 SGTC_1246 0422-0085 105 µM 0.546311373479235 0.313119108288865 no 1035 0.292425959754985 1432 264295 SGTC_2664 lyso-paf C-16 73.48 µM 0.5455322889069 0.313365901455791 no 1036 0.292693739750572 1427 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_484 loperamide 105 µM 0.544586827653786 0.313665510582265 no 1037 0.293018858138493 1398 3955 An opioid-receptor agonist. SGTC_2871 9038510 12.99 µM 0.543495890626691 0.314011372595559 no 1038 0.293394209741785 1532 4945164 SGTC_1825 st052143 62.6 µM 0.542829399475145 0.314222752105536 no 1039 0.293623634583272 1480 674173 SGTC_2537 larixol 68.93 µM 0.542208313150954 0.314419786211774 no 1040 0.293837504546392 1425 6708759 SGTC_1797 st048695 56.8 µM 0.540878585899313 0.314841808085934 no 1041 0.294295635875183 1459 592262 YIL048W NEO1 SGTC_909 3448-9333 149 µM 0.5373619794329 0.315959054969772 no 1042 0.295508800350073 1403 3344074 SGTC_296 1222-0039 74.9 µM 0.536547781841813 0.31621797074309 no 1043 0.29579001106195 1371 5984176 SGTC_3295 9122362 53.5725 µM 0.533533600876135 0.317177267506679 no 1044 0.296832128942443 1420 4730473 SGTC_2166 5933061 31.504 µM 0.533217537730383 0.317277929479409 no 1045 0.296941501360363 1594 2877375 SGTC_3198 9112019 49.47 µM 0.531874532906346 0.317705809615296 no 1046 0.297406448425918 1468 45595555 SGTC_108 0509-0257 621.132 µM 0.529068652624657 0.318600546146447 no 1047 0.298378913119796 1402 536624 SGTC_44 0929-0055 61.211 µM 0.528318676518544 0.31883987737171 no 1048 0.298639085471336 1386 1379590 SGTC_1189 1431-2119 7.28 µM 0.528306142957138 0.31884387770487 no 1049 0.298643434334305 1448 3107275 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.527188675915955 0.319200624118012 no 1050 0.299031285858923 1531 23847180 SGTC_2452 5863136 48.41 µM 0.526512620033179 0.319416533307535 no 1051 0.299266042965328 1399 2184096 SGTC_2583 asiatic acid 100 µM 0.526142209301809 0.319534855835275 no 1052 0.299394701729902 1443 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_792 4534-1957 155 µM 0.525325692074924 0.319795745726146 no 1053 0.299678400033966 1457 1717904 SGTC_1472 k841-0093 193 µM 0.52521807574592 0.319830137462594 no 1054 0.299715800328634 1496 X1472 SGTC_859 0439-0102 54.6 µM 0.522654064322981 0.32064999483293 no 1055 0.300607505041583 1481 610143 SGTC_104 0074-0074 590.992 µM 0.522152281663342 0.320810545301415 no 1056 0.300782153649166 1373 3943124 SGTC_3300 9124615 50.48 µM 0.521484974576074 0.321024108920183 no 1057 0.301014484968536 1521 24824903 SGTC_1434 4073-0095 163 µM 0.520839523007523 0.321230734287905 no 1058 0.301239283950074 1446 24133745 SGTC_2019 4016004 108 µM 0.519383283436443 0.321697116634615 no 1059 0.301746743103723 1406 45595336 SGTC_2582 agaric acid 100 µM 0.518016364722054 0.322135148462658 no 1060 0.302223425783672 1337 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2467 5474540 200 µM 0.51689075565266 0.322496037743953 no 1061 0.302616210590988 1420 5413519 SGTC_2789 5281112 71.43 µM 0.514810629389916 0.323163401491322 no 1062 0.303342678449217 1416 765948 SGTC_1416 3966-0321 25.3 µM 0.513795345108109 0.323489340586623 no 1063 0.303697541373709 1452 582530 YLR208W SEC13 SGTC_565 1418-0001 44.5 µM 0.513587352553635 0.323556129653203 no 1064 0.303770261948049 1517 2862145 SGTC_3187 9109394 49.47 µM 0.513561525598979 0.323564423415107 no 1065 0.303779292385543 1372 17098090 SGTC_142 0335-0849 62.6745 µM 0.512498254007922 0.323905945881781 no 1066 0.304151170978787 1498 3889043 YPR107C YTH1 SGTC_2564 betulinic acid 100 µM 0.512304271866839 0.323968268881985 no 1067 0.304219037987575 1657 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1501 4491-0275 38.4 µM 0.512189822130919 0.324005041854453 no 1068 0.304259082781946 1460 5104718 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.510385928651422 0.324584863789939 no 1069 0.304890556531757 1447 3256 An antibiotic and ribosome inhibitor. SGTC_1792 st045773 43.6 µM 0.509406713945592 0.324899789089967 no 1070 0.305233585616194 1449 2919270 SGTC_2478 5763493 32.33 µM 0.508548378426143 0.325175941389348 no 1071 0.305534410238304 1510 1365576 YLR208W SEC13 SGTC_13 0199-0087 65 µM 0.506670364074104 0.325780489791857 no 1072 0.306193064017037 1490 4589825 SGTC_129 0088-0017 176.636 µM 0.505608068577185 0.32612265462733 no 1073 0.306565908123617 1497 182446 SGTC_2316 5844804 197.44 µM 0.505243540980053 0.326240102540972 no 1074 0.306693896071393 1531 776813 SGTC_571 k831-0106 44.2 µM 0.503180762220556 0.326905037982191 no 1075 0.307418594532671 1564 4783639 SGTC_378 3970-0959 8.33 µM 0.502975820115476 0.326971131011537 no 1076 0.307490636231875 1485 6615653 SGTC_3350 9150499 3.57 µM 0.498988785608445 0.328258011888578 no 1077 0.308893642207152 1442 4910996 YPR165W RHO1 SGTC_1395 3486-0190 4.35 µM 0.498467404543379 0.328426447392842 no 1078 0.309077319024744 1599 6748079 SGTC_40 0327-0103 19.753 µM 0.497816270437914 0.328636849424496 no 1079 0.309306773450353 1451 409036 SGTC_597 k018-0003 82.8 µM 0.497743309960872 0.328660428649744 no 1080 0.309332488772096 1586 6786234 SGTC_2516 gossypol 71.55 µM 0.496651971622381 0.329013206627241 no 1081 0.309717248377593 1592 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_853 0419-0306 21 µM 0.493597160826144 0.330001491493468 no 1082 0.310795353154557 1431 762713 SGTC_1279 0874-0590 65.2 µM 0.492458323784798 0.330370229526811 no 1083 0.31119768857908 1512 3523074 SGTC_274 sirtinol 40.1 µM 0.490300524844679 0.33106934349218 no 1084 0.311960627839801 1446 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_856 0433-0016 11.3 µM 0.490135491237962 0.331122837687338 no 1085 0.312019012532751 1501 3911780 SGTC_174 3553-0389 74.3 µM 0.490106258411462 0.331132313610887 no 1086 0.312029354855736 1515 738071 SGTC_2551 apiole 73.87 µM 0.490064392846353 0.331145884669454 no 1087 0.312044166791221 1464 10659 A possible DNA adduct former. SGTC_591 4299-0174 154 µM 0.488275100220588 0.331726105339659 no 1088 0.312677497976268 1515 5509088 SGTC_224 benfluorex 43.875 µM 0.487617639815535 0.33193940405508 no 1089 0.312910349302451 1579 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2788 5282734 71.43 µM 0.487615946902649 0.331939953354158 no 1090 0.312910948974142 1643 743706 SGTC_633 0437-0093 97.7 µM 0.486466685556813 0.332312937239168 no 1091 0.31331815998691 1500 2831118 SGTC_668 1682-0499 62.6 µM 0.486101305379569 0.332431553374996 no 1092 0.313447670724497 1507 682214 SGTC_8 0354-0001 70 µM 0.4857701674853 0.332539067677333 no 1093 0.313565063994566 1538 4993152 SGTC_2669 eugenol 100 µM 0.482805753800713 0.333502170397023 no 1094 0.314616832501331 1542 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_718 1130-0073 349 µM 0.479633969917086 0.334533861716224 no 1095 0.315743843546924 1574 6740020 SGTC_714 4296-0578 26.1 µM 0.479435993115696 0.334598299502579 no 1096 0.315814246444807 1557 1589775 SGTC_3301 9125354 19.7965 µM 0.478023243482888 0.33505826470883 no 1097 0.316316830830505 1486 41905162 SGTC_2735 sertaconazole 140 nM 0.478002441470968 0.335065039310444 no 1098 0.31632423366552 1565 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2470 5664817 21.68 µM 0.477967310773519 0.33507648046406 no 1099 0.316336735832845 1531 2859561 SGTC_2303 7774051 200 µM 0.477069507495871 0.335368923522317 no 1100 0.316656313553839 1594 2953184 SGTC_2876 9059903 25.97 µM 0.476007649137537 0.335714933331973 no 1101 0.317034464234589 1500 6916095 SGTC_1022 4477-0945 21.3 µM 0.475458587069772 0.335893901562036 no 1102 0.317230072096068 1494 4648966 SGTC_2440 5628896 157.78 µM 0.475230748004477 0.335968177235403 no 1103 0.317311256626281 1540 5522048 SGTC_2442 5158906 48.48 µM 0.475098991134 0.33601113297875 no 1104 0.31735820877513 1626 1893835 SGTC_3268 9137683 49.47 µM 0.475087752426874 0.336014797152625 no 1105 0.317362213874631 1525 1953228 SGTC_665 3914-0008 307 µM 0.474851165430886 0.33609193561042 no 1106 0.317446530533497 1467 1069549 SGTC_1121 fusaric acid 630.51 nM 0.47362784158525 0.336490906631257 no 1107 0.317882658962479 1494 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2212 7123476 200 µM 0.473523299058793 0.33652501035214 no 1108 0.317919941255515 1544 1085715 SGTC_2137 5261020 140 µM 0.472775808445401 0.336768894892453 no 1109 0.318186567527233 1503 763655 SGTC_1975 st070967 30.8 µM 0.47275926474104 0.336774293401054 no 1110 0.318192469652633 1602 261391 SGTC_1094 duloxetine 25.4 µM 0.472504462377013 0.336857444247545 no 1111 0.318283378672716 1522 60834 A selective serotonin reuptake inhibitor. SGTC_2922 7999257 32.47 µM 0.47244592939227 0.336876546716541 no 1112 0.318304263762532 1483 2988377 SGTC_269 exalamide 29 µM 0.471169122570216 0.337293342250847 no 1113 0.318759983410325 1565 3316 A derivative of salicylamide. SGTC_2932 9016711 44.54 µM 0.467953131826628 0.338344041234287 no 1114 0.319909053247508 1643 7117328 SGTC_1729 st035615 45.989 µM 0.466359937110491 0.338865022435565 no 1115 0.320478941506674 1514 17385451 SGTC_2377 9073351 62.6 µM 0.465717401081871 0.339075221671671 no 1116 0.320708897584256 1500 7337946 YHR072W ERG7 SGTC_968 1309-0633 340 µM 0.465193866698912 0.339246527757357 no 1117 0.320896315260966 1560 3761976 SGTC_476 mead acid 10 µM 0.464708055509794 0.339405520136528 no 1118 0.321070269419817 1554 5312531 An omega 9 fatty acid. SGTC_533 1222-0222 6.71 µM 0.464323110316786 0.339531522208573 no 1119 0.321208134436557 1634 3982874 SGTC_1516 st013856 110 µM 0.463779506499027 0.339709487719395 no 1120 0.321402863729758 1512 5281404 A mutagen and neurotoxin. SGTC_2075 5212009 200 µM 0.463441788403426 0.339820068176932 no 1121 0.32152386554623 1573 780898 SGTC_3154 9100113 49.47 µM 0.461706251081218 0.340388559746342 no 1122 0.322145993849306 1491 25237525 SGTC_531 3788-1495 174 µM 0.460399370917759 0.340816880242158 no 1123 0.3226147930741 1518 2896655 SGTC_1316 1272-0050 65.9 µM 0.460263999046452 0.340861259134472 no 1124 0.3226633693096 1535 7340392 SGTC_1481 3346-2004 36 µM 0.458455917995594 0.341454212372768 no 1125 0.323312462918917 1532 2770522 SGTC_1807 st050092 58.9 µM 0.452606705200544 0.343375115210818 no 1126 0.325415984821358 1523 5008496 SGTC_3072 9116419 49.47 µM 0.452139482212205 0.343528728391306 no 1127 0.325584251044449 1492 17170162 SGTC_717 1532-0246 73.2 µM 0.451798433271165 0.343640874495394 no 1128 0.325707099248848 1525 9561992 SGTC_1098 clofazimine 15.1 µM 0.450485923490161 0.344072591489615 no 1129 0.326180050927369 1598 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2213 7173844 200 µM 0.448844590407623 0.344612752694486 no 1130 0.326771884815672 1526 892728 SGTC_101 0490-5701 117.494 µM 0.447587319003361 0.345026734029716 no 1131 0.32722552835896 1629 4661669 SGTC_1353 1498-1206 8.11 µM 0.446055886024985 0.345531239095885 no 1132 0.327778438657505 1543 6756808 SGTC_1793 st048256 72.231 µM 0.445411697819613 0.345743538236367 no 1133 0.328011130048643 1516 672022 SGTC_2222 6885208 172.143 µM 0.445159917014269 0.345826528494985 no 1134 0.328102095577271 1552 609514 SGTC_2379 9035213 200 µM 0.443626881789665 0.346331996773635 no 1135 0.328656183565506 1698 646551 SGTC_130 0136-0219 337.655 µM 0.443301022856414 0.346439473427404 no 1136 0.328774008025816 1622 234244 SGTC_2721 ifenprodil 61.44 µM 0.442406473098817 0.346734582475584 no 1137 0.329097547861651 1647 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2856 9022925 19.48 µM 0.441918111909971 0.346895730503801 no 1138 0.329274231889785 1584 4944862 SGTC_375 3970-0961 9.27 µM 0.440932440343543 0.347221063930301 no 1139 0.32963095379427 1584 2898222 SGTC_2372 9071633 200 µM 0.440865978192872 0.347243004663041 no 1140 0.329655012526884 1599 21321366 SGTC_2643 anethole 100 µM 0.439975445853298 0.347537039878425 no 1141 0.329977445621655 1555 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_152 4469-0003 551.229 µM 0.43957595117789 0.347668974516932 no 1142 0.330122130853208 1580 697280 SGTC_1054 3429-0080 167 µM 0.43879123056184 0.34792818519608 no 1143 0.330406407560183 1642 1162877 SGTC_1857 st056007 79.3 µM 0.436827985519341 0.348576999873416 no 1144 0.331118050806742 1581 619834 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.436658747616202 0.348632950516982 no 1145 0.33117942531154 1569 5106787 A p450 inhibitor. SGTC_2529 gangaleoidin 93.61 µM 0.436211366523798 0.348780872127309 no 1146 0.331341690906469 1595 4565183 SGTC_2361 9034121 116 µM 0.434075368930753 0.349487432669862 no 1147 0.332116855596991 1560 6496917 SGTC_2349 9023730 187.07 µM 0.433458583959463 0.349691554409028 no 1148 0.33234082400704 1671 4126287 SGTC_123 0083-0120 66.675 µM 0.432888762890284 0.349880172316401 no 1149 0.332547791995866 1508 16001701 SGTC_916 4466-0038 42 nM 0.432125184905276 0.350132984274757 no 1150 0.332825215592191 1651 5722064 YGL116W CDC20 SGTC_1710 st031758 61.5 µM 0.431504428575114 0.350338558575232 no 1151 0.333050816616956 1650 5394341 SGTC_262 fenpropimorph 62.5 µM 0.430274972235415 0.350745843900741 no 1152 0.333497815367301 1542 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1078 idebenone 36.1 µM 0.430135200430877 0.350792157355446 no 1153 0.333548647789495 1586 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2295 7971645 200 µM 0.429520891105587 0.35099573532534 no 1154 0.333772096961064 1645 2978226 YKL099C UTP11 SGTC_258 haloperidol 50.781 µM 0.429320492250785 0.351062155411268 no 1155 0.33384500289652 1530 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2982 9019404 25.97 µM 0.428841493892094 0.351220932797046 no 1156 0.33401928989911 1413 22333232 SGTC_1317 1273-0028 910 nM 0.428796933677756 0.351235704845661 no 1157 0.334035505274875 1578 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_433 pimozide 108 µM 0.428606583934465 0.35129880975799 no 1158 0.334104776666436 1494 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_347 4534-1311 26.2 µM 0.428163363264824 0.351445762543692 no 1159 0.334266093830282 1559 2862016 SGTC_479 n-linoleoylglycine 10 µM 0.427652749034304 0.351615087644994 no 1160 0.334451977896648 1578 6433346 An anti-infammatory. SGTC_1064 honokiol 6.76 µM 0.427125365686809 0.351790004474284 no 1161 0.33464400921072 1587 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.427084276219831 0.35180363390419 no 1162 0.334658972562747 1627 17037758 SGTC_2458 5808907 16.39 µM 0.426801699364722 0.351897370174139 no 1163 0.334761884317777 1645 2731747 SGTC_1903 st060211 78.3 µM 0.425667699332594 0.352273630666606 no 1164 0.335175000937827 1695 688960 SGTC_1753 st043925 64 µM 0.42553201562022 0.352318660131967 no 1165 0.33522444393233 1652 670181 SGTC_3156 9099931 49.47 µM 0.425110729390144 0.352458485930631 no 1166 0.335377978357465 1623 18111053 SGTC_1643 st009866 20.2 µM 0.424588251984467 0.35263192499571 no 1167 0.335568429302073 1656 3156273 YOR207C RET1 SGTC_3120 9124077 49.47 µM 0.423989584905482 0.352830693279757 no 1168 0.335786704482067 1599 18774327 YGL155W CDC43 SGTC_138 0850-0259 40.9225 µM 0.420957293514212 0.353838084903989 no 1169 0.336893133598178 1587 6813004 SGTC_473 2-arachidonoylglycerol 10 µM 0.420617097898767 0.353951169143662 no 1170 0.337017353242335 1568 5282280 An endocannabinoid. SGTC_2072 5231554 129 µM 0.419746917041495 0.354240484098898 no 1171 0.337335173518296 1730 789545 SGTC_2208 7283366 200 µM 0.418914671927677 0.354517265030705 no 1172 0.337639246970343 1684 898663 SGTC_986 1493-0483 84 µM 0.41887255810225 0.354531272928781 no 1173 0.33765463671903 1668 40079 SGTC_912 3474-0017 2.18 µM 0.418458457077137 0.354669021662935 no 1174 0.337805977031106 1697 3360550 SGTC_3185 9108267 49.47 µM 0.417613209970743 0.354950248062667 no 1175 0.338114968442411 1550 4910486 SGTC_3292 9120825 59.784 µM 0.416013231817942 0.355482801138111 no 1176 0.338700160444301 1734 24824900 SGTC_1184 1269-1718 139 µM 0.415514462130705 0.355648874500509 no 1177 0.338882665177967 1712 5403821 SGTC_2182 6325192 200 µM 0.415425741833684 0.35567841821738 no 1178 0.338915132771005 1598 736248 SGTC_1492 4158-0558 28.5 µM 0.41046536968637 0.357331588828057 no 1179 0.340732300994104 1716 3967268 SGTC_2160 5660466 132.927 µM 0.409857786189484 0.357534266477286 no 1180 0.340955136710724 1694 2859134 SGTC_1808 st050063 61.5 µM 0.409489423961111 0.357657164288199 no 1181 0.341090263295082 1685 4011993 SGTC_1006 4099-6547 255 µM 0.409283076157781 0.357726015184255 no 1182 0.341165966918534 1645 3146833 SGTC_2319 6033012 152.6 µM 0.408698795761949 0.357920993802395 no 1183 0.341380358820875 1532 847246 SGTC_2 0422-0095 29 µM 0.408349937093191 0.358037428156191 no 1184 0.341508391080847 1581 6790840 SGTC_2967 9089538 49.85 µM 0.407915860387843 0.358182323145305 no 1185 0.341667724102497 1792 728216 SGTC_489 paxilline 115 µM 0.407640591263476 0.358274218681837 no 1186 0.341768779532339 1577 105008 A toxic potassium channel blocker. SGTC_2305 7443522 69.23 µM 0.407504634243462 0.358319609450447 no 1187 0.34181869558039 1696 5415886 SGTC_2928 9011484 9.79 µM 0.406654897651153 0.358603348835282 no 1188 0.342130735424093 1621 2994751 SGTC_862 0452-0056 10.2 µM 0.405540797221312 0.358975481400328 no 1189 0.342540018183981 1610 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_606 k015-0008 38.6 µM 0.405160701696421 0.359102471805418 no 1190 0.342679694741897 1733 1970475 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.405062962503447 0.359135129113051 no 1191 0.342715615175084 1680 5393153 SGTC_1039 k821-0043 94 µM 0.4050130725659 0.359151799087228 no 1192 0.342733950928621 1716 15992768 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.404913028956403 0.35918522796649 no 1193 0.342770720480794 1588 115019 SGTC_2059 5238311 157 µM 0.404354193529988 0.359371978778326 no 1194 0.342976139584175 1590 703021 SGTC_3124 9127567 49.47 µM 0.403077562519138 0.35979872746088 no 1195 0.343445583116347 1733 17592030 SGTC_1632 st005650 90 µM 0.401463211268767 0.360338618633284 no 1196 0.344039559224202 1622 2759605 SGTC_449 xestospongin c 11.1929 µM 0.400969605075215 0.360503752146108 no 1197 0.344221251084226 1688 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1159 4092-0538 61.2 µM 0.400965449887385 0.360505142354148 no 1198 0.344222780723014 1665 717301 SGTC_2848 9016370 25.97 µM 0.398590107975861 0.361300165706987 no 1199 0.345097625787801 1767 7894410 SGTC_1602 st001878 87.6 µM 0.398539094272983 0.361317246502788 no 1200 0.345116423381682 1685 595405 YLR310C CDC25 SGTC_640 3381-0960 37.1 µM 0.398255576764356 0.361412181027216 no 1201 0.345220901235692 1703 1745025 SGTC_2481 5478948 45.16 µM 0.396315215328954 0.362062130843854 no 1202 0.345936252022523 1617 77792 SGTC_501 nsc-95397 161 µM 0.395362559120608 0.362381381463048 no 1203 0.346287668236019 1713 262093 SGTC_2909 7941780 10.49 µM 0.395227834445932 0.362426537628357 no 1204 0.346337376220262 1773 1243215 SGTC_1186 1319-0216 26 µM 0.394238682311715 0.362758133970993 no 1205 0.346702414566352 1793 4565136 SGTC_892 0929-0076 29 µM 0.393606138727251 0.362970237376775 no 1206 0.346935924156235 1621 5751038 SGTC_1230 0170-0365 3.77 µM 0.393343647052336 0.363058267971494 no 1207 0.347032842575451 1709 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1345 1488-0192 31.4 µM 0.392750747006394 0.363257132685608 no 1208 0.347251792759329 1725 658348 SGTC_1254 0550-0035 264 µM 0.390094796510082 0.364148417299974 no 1209 0.348233225217818 1714 15121435 SGTC_1583 clindamycin 39.6 µM 0.388082370308063 0.364824237779876 no 1210 0.348977539002514 1561 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_755 1995-0008 37.3 µM 0.387540167231264 0.365006394390683 no 1211 0.349178177200886 1638 689533 SGTC_2694 st077685 81.9 µM 0.387532828789843 0.365008859996348 no 1212 0.349180893025623 1586 2838096 SGTC_653 0203-0016 55.2 µM 0.38522446802565 0.365784710931205 no 1213 0.350035558362682 1693 295302 SGTC_3101 9120531 49.47 µM 0.382784171081593 0.366605503523893 no 1214 0.35093989945687 1742 24824904 SGTC_1387 3342-1166 1.8 µM 0.379834941085527 0.367598289912068 no 1215 0.352033971753286 1668 3418228 SGTC_784 4579-0127 173 µM 0.377840866927684 0.368270048556498 no 1216 0.352774406409083 1790 1948547 SGTC_1868 st057644 42.7 µM 0.37741730281476 0.368412789711676 no 1217 0.352931755129028 1622 688665 SGTC_2272 7805186 180 µM 0.376794754467852 0.368622621537718 no 1218 0.353163069631143 1748 2956062 YPR165W RHO1 SGTC_3010 9080089 71.4286 µM 0.376605855794951 0.368686298163903 no 1219 0.353233267689692 1742 17027233 SGTC_2642 cholecalciferol 100 µM 0.376367216061391 0.368766747362124 no 1220 0.353321957537963 1723 9821465 A vitamin D precursor, similar to steriods. SGTC_3 0833-0587 95.581 µM 0.376260562056748 0.368802703960119 no 1221 0.353361597802718 1665 5382644 SGTC_1572 epiandrosterone 68.9 µM 0.375608951506703 0.369022408393462 no 1222 0.353603817474369 1712 441302 A steroid. SGTC_371 0195-0006 7.36 µM 0.375394169729051 0.369094836045987 no 1223 0.353683670141761 1582 3928593 SGTC_2797 7859098 81.82 µM 0.374202405400678 0.369496801320173 no 1224 0.354126867269523 1653 972681 SGTC_2380 9035439 200 µM 0.372070558688981 0.370216198771823 no 1225 0.354920157996093 1751 6462575 SGTC_2088 5278280 127.392 µM 0.371200430054537 0.370509956720475 no 1226 0.355244126410833 1685 791502 SGTC_3307 9126885 69.2785 µM 0.370400928704688 0.370779937273031 no 1227 0.355541890966493 1606 24824909 SGTC_2228 7354201 200 µM 0.36903181103928 0.371242417109345 no 1228 0.356052006927187 1755 753451 SGTC_1030 k029-0042 36.7 µM 0.367182268781564 0.37186747676454 no 1229 0.356741532238591 1685 6080581 SGTC_2951 9072950 58.06 µM 0.366677966491673 0.37203796628443 no 1230 0.356929621843627 1717 16488155 SGTC_2983 9022671 12.99 µM 0.36603964391629 0.372253800029662 no 1231 0.357167746862382 1825 6405161 SGTC_553 k007-0256 45.7 µM 0.365646296991682 0.372386821019232 no 1232 0.357314511896995 1710 6287000 SGTC_1607 st000305 50.6 µM 0.365263756019851 0.372516202285914 no 1233 0.357457265278527 1729 5457690 SGTC_477 mead ethanolamide 10 µM 0.364491829649933 0.3727773235049 no 1234 0.357745386907309 1664 16061185 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.36434903366721 0.372825633826066 no 1235 0.357798694419231 1636 2333 A French combination drug. SGTC_2904 7225135 42.03 µM 0.364092774338309 0.372912335751521 no 1236 0.357894366160109 1738 4446116 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.362464907234554 0.373463253043101 no 1237 0.358502321560406 1758 77254 SGTC_2751 anetholtrithion 17.25 µM 0.362093886388233 0.373588853468549 no 1238 0.358640936037233 1792 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2682 pyrogallin 40.03 µM 0.361647658541705 0.373739931250371 no 1239 0.358807672736955 1726 822798 An ATP competetive kinase inhibitor. SGTC_3328 9140624 29.0385 µM 0.359268426399393 0.374545786452752 no 1240 0.359697145909692 1805 4904392 SGTC_821 1114-0266 29.2 µM 0.358501478887284 0.374805671588615 no 1241 0.35998403067116 1657 3123235 SGTC_338 4055-0136 114 µM 0.357720423800878 0.375070395612878 no 1242 0.360276273598231 1654 2900563 SGTC_2775 cyproheptadine 69.59 µM 0.357372495123159 0.37518833849331 no 1243 0.360406482387936 1761 2913 A selective serotonin reuptake inhibitor. SGTC_3122 9126309 49.47 µM 0.356975628733768 0.375322884810184 no 1244 0.360555025388023 1770 17591206 SGTC_284 0988-0104 32.6 µM 0.356648317697482 0.375433861767837 no 1245 0.360677550373332 1760 4666532 SGTC_923 1900-2434 73.3 µM 0.355807632164943 0.375718948945387 no 1246 0.360992316505396 1638 5910570 SGTC_2636 apigenin dimethyl ether 100 µM 0.354218400171327 0.376258063055919 no 1247 0.361587607533981 1725 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_316 k060-0003 58.6 µM 0.353819179257665 0.376393528498144 no 1248 0.36173719955688 1767 6152314 SGTC_1259 0671-0132 43 µM 0.353779608023532 0.376406956817599 no 1249 0.361752028440944 1685 X1259 SGTC_931 2812-0076 566 µM 0.353760755732551 0.376413354309946 no 1250 0.361759093202319 1667 3450959 SGTC_1996 st072960 66.8 µM 0.352483104348105 0.376847002129667 no 1251 0.362237993617418 1816 1719405 SGTC_2152 5568786 200 µM 0.351082032251523 0.377322718838258 no 1252 0.362763403619032 1719 5399883 SGTC_3194 9111903 49.47 µM 0.350485041054379 0.37752547643845 no 1253 0.362987357306278 1747 17087251 SGTC_1667 st014849 34.6 µM 0.349898253643575 0.377724801399992 no 1254 0.363207528842212 1733 5348460 SGTC_1355 1499-0035 1.68 µM 0.349749991270475 0.377775169585269 no 1255 0.3632631662904 1673 1548538 SGTC_723 4182-0001 115 µM 0.349650124881453 0.377809097697688 no 1256 0.363300644121367 1667 744821 YLR208W SEC13 SGTC_1594 piperine 70.1 µM 0.349135502737012 0.377983947815654 no 1257 0.363493792118428 1667 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2002 4023503 131 µM 0.348371154747172 0.378243691932578 no 1258 0.363780731268553 1885 4736863 YCR052W RSC6 SGTC_1331 1472-0049 76.2 µM 0.346853952465022 0.378759437267607 no 1259 0.364350521029735 1660 24051409 SGTC_1713 st033146 12.748 µM 0.345579501889744 0.37919283052583 no 1260 0.364829376509507 1821 674619 SGTC_3342 9147791 14.508 µM 0.34522975950573 0.379311791490597 no 1261 0.364960823823942 1710 1838168 SGTC_2090 5301565 104.445 µM 0.345091766424962 0.379358731440187 no 1262 0.365012691564851 1719 2056344 SGTC_306 1672-3436 11.6 µM 0.34475226181633 0.379474225446243 no 1263 0.365140312367313 1766 6797378 SGTC_2607 solasodine 47.35 µM 0.34464069195327 0.379512182067324 no 1264 0.365182255075864 1663 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_839 0122-0028 230 µM 0.344080170369029 0.379702891856542 no 1265 0.365392997606126 1731 759448 SGTC_2418 pentamidine 31.67 µM 0.344073069691874 0.379705307952466 no 1266 0.36539566754949 1635 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2371 9071574 200 µM 0.343152957678309 0.380018427496745 no 1267 0.365741696312125 1786 45596039 SGTC_559 1550-0661 158 µM 0.342345741194804 0.38029319281353 no 1268 0.366045358170389 1761 5830875 SGTC_2659 sanguinarine 24.21 µM 0.340494393342569 0.380923593966491 no 1269 0.36674212215059 1716 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1590 st077108 57.8 µM 0.336639166913659 0.382237347494408 no 1270 0.368194463427399 1850 5489485 SGTC_117 lucigenin 22.078 µM 0.336394638478203 0.382320721876644 no 1271 0.368286646014649 1630 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.333951686640349 0.38315396934995 no 1272 0.36920800807755 1830 165506 SGTC_2120 5538279 151.968 µM 0.333230993147258 0.38339988859331 no 1273 0.369479962310202 1754 2058197 SGTC_2245 6637752 200 µM 0.330068879231875 0.384479437679411 no 1274 0.370673958734713 1861 681890 SGTC_552 k242-0005 476 µM 0.328208555507088 0.385114973638664 no 1275 0.371376989734826 1730 4088318 SGTC_354 2783-3500 4.88 µM 0.326456469600473 0.385713815036476 no 1276 0.372039509485302 1666 6740761 SGTC_2106 5357045 167.29 µM 0.32623461428913 0.385789661917503 no 1277 0.372123427153465 1803 668842 SGTC_171 k064-0041 9.68 µM 0.326187080238075 0.385805913209994 no 1278 0.372141407890619 1683 53325 SGTC_2975 9084847 53.72 µM 0.326145939069984 0.385819979018246 no 1279 0.372156970612751 1721 27211724 SGTC_2277 7947813 106.88 µM 0.325860827919655 0.385917460169921 no 1280 0.372264827094008 1845 1246798 SGTC_2260 7964312 200 µM 0.324584128286619 0.386354059435047 no 1281 0.372747920581751 1856 231951 SGTC_1238 0333-0287 48.8 µM 0.323992923000824 0.386556285610088 no 1282 0.372971696064537 1726 7226 SGTC_2480 5767542 37.17 µM 0.323189660904719 0.386831096761285 no 1283 0.373275805261501 1786 2867358 SGTC_228 caffeine 993.056 µM 0.322536066239701 0.38705474573578 no 1284 0.373523309725342 1821 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2253 7938677 135.83 µM 0.322417695877624 0.387095254072953 no 1285 0.373568140021648 1866 2301972 SGTC_756 0508-1999 28.3 µM 0.321645949607196 0.387359388806497 no 1286 0.373860464679876 1652 6753853 SGTC_3257 9139206 32.98 µM 0.321540956506344 0.387395327350303 no 1287 0.373900239932825 1822 4910041 SGTC_3063 1327-0034 4 µM 0.321417515667663 0.387437581684529 no 1288 0.373947005585622 1809 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_99 0109-0120 622.8 µM 0.320911882311202 0.387610676087183 no 1289 0.374138584515462 1830 759414 SGTC_2845 9003024 42.97 µM 0.317713237958139 0.388706190282931 no 1290 0.37535123434725 1837 2990173 SGTC_1251 0490-5699 265 µM 0.316428761468121 0.389146364593288 no 1291 0.375838544560794 1896 3883818 SGTC_1997 st073024 93.8 µM 0.316120016606837 0.389252188898293 no 1292 0.375955707072833 1856 686268 SGTC_23 0213-0011 39.996 µM 0.316102585047209 0.389258163923552 no 1293 0.375962322342909 1866 627608 SGTC_158 k038-0087 26.446 µM 0.315632763100561 0.389419214909159 no 1294 0.376140633313313 1767 X158 SGTC_14 0354-0009 295 µM 0.315089626991286 0.389605421039889 no 1295 0.376346802074863 1802 1713507 SGTC_1141 3253-0389 52.6 µM 0.314868881938855 0.389681107441569 no 1296 0.376430604665898 1850 5402031 SGTC_2835 9006588 71.43 µM 0.313521199504578 0.390143275188233 no 1297 0.376942358551671 1718 2345538 SGTC_1272 0839-0021 27 µM 0.313401850317057 0.390184211721869 no 1298 0.376987689316972 1781 5027250 SGTC_595 3909-8003 73.7 µM 0.31249198237562 0.390496334611927 no 1299 0.37733332767455 1792 699517 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.312182028558739 0.390602677907276 no 1300 0.377451094612501 1772 4213774 SGTC_2699 st077704 54.6 µM 0.311650184087626 0.390785169619387 no 1301 0.377653195441542 1762 645852 SGTC_2602 kawain 100 µM 0.309852163489755 0.39140230206876 no 1302 0.378336690803249 1812 5369129 SGTC_1645 Cervolide 78 µM 0.309500216915747 0.391523132319345 no 1303 0.378470523592111 1761 23173 A fragrance. SGTC_2555 cholic acid 100 µM 0.308707601578824 0.391795291224452 no 1304 0.378771980433759 1802 6708657 Influences liver metabolism. SGTC_1876 myriocin 605 nM 0.308433489827439 0.391889424815947 no 1305 0.378876251034287 1879 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_379 3970-0972 5.9 µM 0.306234218318614 0.39264491232119 no 1306 0.379713160322662 1791 2898042 YBL034C STU1 SGTC_576 1073-0113 22.7 µM 0.305024925630659 0.393060497736794 no 1307 0.380173584231549 1881 5439563 SGTC_2850 9015429 58.44 µM 0.30437207527337 0.393284906934956 no 1308 0.380422219939201 1724 6457570 SGTC_3055 9094636 49.47 µM 0.303537117000982 0.393571965135165 no 1309 0.380740282785329 1831 25236176 SGTC_1888 azatryptophan 97.5 µM 0.303179042901736 0.393695088550613 no 1310 0.380876709604249 1753 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1080 nisoldipine 24.4 µM 0.30268810748881 0.393863913467692 no 1311 0.381063780872787 1761 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1060 3448-7350 82 µM 0.301580174118997 0.394244987481792 no 1312 0.381486061729859 1882 570178 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.301415146591366 0.394301757422187 no 1313 0.381548972875252 1826 66535 A nucleotide analog. SGTC_1696 st025591 34.7925 µM 0.300826775483039 0.394504177027959 no 1314 0.381773294853465 1784 2787147 SGTC_1399 3562-5772 25 µM 0.300523697257105 0.394608457332187 no 1315 0.38188886175635 1774 23847490 SGTC_3001 9076041 71.4286 µM 0.30043499393874 0.394638978964323 no 1316 0.381922687252688 1770 16004211 SGTC_1958 st076513 41.9 µM 0.299270280978427 0.395039801135856 no 1317 0.382366914194876 1757 732122 YGL099W LSG1 SGTC_2571 chrysanthemic acid 100 µM 0.299025427740279 0.395124078624842 no 1318 0.382460322078448 1696 2743 An insecticide. SGTC_2203 7227154 166.4 µM 0.29744004390364 0.39566987986048 no 1319 0.383065287809928 1791 896304 SGTC_1328 1441-0025 69.2 µM 0.296170950423989 0.396106939133791 no 1320 0.383549766178321 1681 4562601 SGTC_885 0865-0106 16.8 µM 0.295579622953993 0.396310629262138 no 1321 0.383775568587135 1721 2793380 SGTC_810 3825-7150 143 µM 0.295564116535167 0.396315971022784 no 1322 0.383781490349833 1954 22330411 YGL099W LSG1 SGTC_1531 st059297 52.4 µM 0.295021682763816 0.396502844681443 no 1323 0.383988658028 1812 7566702 SGTC_2748 diazoxide 86.69 µM 0.294602541969481 0.396647259009348 no 1324 0.38414876005127 1849 3019 A potassium channel activatior. SGTC_1816 st051957 91.6 µM 0.294586064520833 0.396652936579174 no 1325 0.384155054457018 1795 674121 SGTC_3241 9133421 49.47 µM 0.294334766075058 0.396739528213156 no 1326 0.384251054559222 1812 17018221 SGTC_803 4488-1585 147 µM 0.294326591274673 0.396742345145897 no 1327 0.384254177585496 1872 747204 SGTC_3029 9088683 49.47 µM 0.293972970939534 0.396864203393697 no 1328 0.384389278667408 1800 25236615 SGTC_1179 1021-1431 9.29 µM 0.293853674455008 0.396905315464373 no 1329 0.384434859204478 1813 2840958 SGTC_2606 farnesol 9.78 µM 0.293647159574585 0.396976487531994 no 1330 0.384513767730363 1889 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2957 9076800 11.52 µM 0.290906344545077 0.397921389928721 no 1331 0.385561474412039 1741 16459615 SGTC_1474 0330-0125 5.35 µM 0.290604481096521 0.39802549478215 no 1332 0.385676916253534 1789 X1474 SGTC_647 0140-0236 81 µM 0.28970126525756 0.398337033771789 no 1333 0.38602239414111 1827 990837 SGTC_685 1278-0033 54.9 µM 0.288805409086052 0.398646098273163 no 1334 0.386365146282755 1880 3590572 SGTC_1290 0986-0249 10.2 µM 0.287341001796763 0.399151445995692 no 1335 0.386925615408684 1897 53329 SGTC_2991 9074669 71.4286 µM 0.287331926755825 0.399154578201078 no 1336 0.386929089414132 1857 17333109 SGTC_53 0973-0023 39.979 µM 0.286063187646989 0.399592541031497 no 1337 0.387414862940017 1968 674768 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.282949694052936 0.40066783902457 no 1338 0.388607700026561 1871 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_372 0155-0182 15.9 µM 0.282357247680899 0.400872536002078 no 1339 0.388834796590454 1862 771486 SGTC_2436 5633522 8.09 µM 0.281508329354047 0.401165894397243 no 1340 0.389160270197164 1943 5724242 SGTC_181 1447-1644 8.07 µM 0.280574867098523 0.401488532733489 no 1341 0.389518247567219 1930 534600 SGTC_957 1187-1561 14.1 µM 0.279096891530755 0.401999511868499 no 1342 0.390085234294057 1871 1538454 SGTC_841 0251-0215 91.2 µM 0.278929257294626 0.402057478494799 no 1343 0.390149557583018 1867 3888614 SGTC_914 3820-6779 408 µM 0.277033387000045 0.402713205491867 no 1344 0.390877234963517 1775 2893481 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.276663707868291 0.4028410988224 no 1345 0.391019170689377 1858 2724278 An inhibitor of dopamine biosynthesis. SGTC_404 fumagillin 50 µM 0.276048990769027 0.403053787928191 no 1346 0.391255219166891 1837 12015870 A methionine aminopeptidase binder. SGTC_2823 7987624 58.44 µM 0.275723829762654 0.40316630364821 no 1347 0.39138009566964 1833 2239440 SGTC_528 3492-0019 172 µM 0.271698391222546 0.404559890542512 no 1348 0.392926969197675 1836 2869262 SGTC_1249 0481-0015 10.2 µM 0.271355898129631 0.40467851613296 no 1349 0.393058659037306 1778 4227577 SGTC_2276 7947513 42.08 µM 0.270293423748595 0.405046569478995 no 1350 0.393467262114436 1674 2105100 SGTC_2793 7325131 81.82 µM 0.268622873471739 0.405625437071964 no 1351 0.39410995428504 1856 4176441 SGTC_882 0843-0131 351 µM 0.266305883230555 0.406428646098596 no 1352 0.395001821246276 1973 5425421 SGTC_2792 7535235 81.82 µM 0.266064719549643 0.406512270714068 no 1353 0.39509468282969 1762 1281891 SGTC_58 0957-0393 9 µM 0.265881054907786 0.406575960133679 no 1354 0.395165408045824 1817 6997992 SGTC_1715 st032160 10.2275 µM 0.265664500248793 0.406651058005027 no 1355 0.395248802921304 1921 5289825 SGTC_652 0437-0092 114 µM 0.265179336379118 0.406819317934676 no 1356 0.395435656212485 1804 3091274 SGTC_3346 9158254 43.5805 µM 0.26387517960451 0.407271698399133 no 1357 0.395938050893006 1838 17639500 SGTC_1796 st049173 110.4 µM 0.263477021290463 0.407409834573208 no 1358 0.396091466192186 1949 94134 SGTC_2988 9073640 71.4286 µM 0.262485204417722 0.407753983380665 no 1359 0.396473695374319 1871 9102229 SGTC_2240 6690706 185.951 µM 0.260716610978058 0.408367841040583 no 1360 0.397155527631737 1736 805876 SGTC_2514 salinomycin 42.74 µM 0.260445750431924 0.408461873399744 no 1361 0.397259978237403 1991 23682228 A polyether potassium ionophore. SGTC_719 2810-4230 27.3 µM 0.259284110938052 0.408865209641844 no 1362 0.397708018977638 1862 721079 SGTC_2273 7815444 169.05 µM 0.258123752032991 0.409268197618604 no 1363 0.398155700543647 1984 2824616 SGTC_1744 st037937 38.9 µM 0.257419197870853 0.409512933265558 no 1364 0.398427592179543 1894 1016152 SGTC_2459 5811157 9.22 µM 0.256792197837923 0.409730759181934 no 1365 0.398669596692536 1968 2870684 YBR192W RIM2 SGTC_2462 5162487 171.77 µM 0.256350822689997 0.409884113921782 no 1366 0.398839978556854 1976 2259986 SGTC_1410 3909-8106 77.9 µM 0.255517678378213 0.410173625473674 no 1367 0.399161645650501 1943 1039210 SGTC_786 4544-0069 423 µM 0.255345468272058 0.410233473337283 no 1368 0.399228142468711 1907 748821 YLR208W SEC13 SGTC_752 1896-0090 130 µM 0.25481249468705 0.410418709916217 no 1369 0.39943396219616 1828 772567 SGTC_415 dibenzyl ketone 100 µM 0.254743918152095 0.410442545350111 no 1370 0.399460446597197 1969 7593 SGTC_446 go6976 132 µM 0.253746299725786 0.410789329137135 no 1371 0.399845781180772 1992 3501 A protein kinase C inhibitor. SGTC_64 000l-0018 272.079 µM 0.25308415013604 0.411019538573286 no 1372 0.4001015933109 1817 6811119 SGTC_2239 6685329 187.64 µM 0.251891772682841 0.411434169478841 no 1373 0.40056235952144 1819 805680 SGTC_219 mitoxanthrone 164.414 µM 0.250790146797401 0.411817330864411 no 1374 0.400988179948885 1931 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_21 0849-0113 22.993 µM 0.250399241449028 0.411953313621459 no 1375 0.401139308085735 1829 1560156 SGTC_3062 9077494 49.47 µM 0.249329183600478 0.412325604616315 no 1376 0.401553079362582 1934 16459633 SGTC_1388 3346-4487 254 µM 0.248237272256457 0.412705580144896 no 1377 0.401975414785417 1921 3345614 SGTC_385 1494-0393 12.4 µM 0.24724966624523 0.413049328813641 no 1378 0.40235750504393 1904 3090647 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.246792693615416 0.413208406452965 no 1379 0.402534332640118 2020 688664 SGTC_400 oxethazaine 37.5 µM 0.246482342851825 0.413316451393593 no 1380 0.402654435625182 1856 4621 A local anesthetic. SGTC_2112 5488546 200 µM 0.243666224270513 0.414297148785751 no 1381 0.403744667062179 1879 600757 SGTC_3054 9094397 49.47 µM 0.243145211567778 0.414478647298287 no 1382 0.403946454066552 1828 2598354 SGTC_2705 st078069 42.8 µM 0.243057004830787 0.414509376556479 no 1383 0.403980618861805 1872 1530061 SGTC_2558 carylophyllene oxide 100 µM 0.241696310116702 0.414983478403253 no 1384 0.404507744456169 1929 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3159 9100096 49.47 µM 0.241602965235932 0.415016006763197 no 1385 0.404543912111567 1904 25236875 SGTC_230 MPP+ 141.667 µM 0.241592560726581 0.415019632510978 no 1386 0.404547943520923 1810 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1862 st057513 3.81 µM 0.241188811633746 0.415160335975273 no 1387 0.404704390999952 1870 5393163 SGTC_3317 9138495 8.753 µM 0.241169350675548 0.415167118245086 no 1388 0.404711932251131 1900 17020139 SGTC_1248 0469-0687 58.6 µM 0.240246285835934 0.415488841314184 no 1389 0.405069666642422 1922 4017482 SGTC_2386 9075165 157.42 µM 0.239061175222169 0.415901980312977 no 1390 0.405529073331456 1911 16452277 SGTC_1440 4100-1550 40 µM 0.238458652222234 0.416112060303373 no 1391 0.405762690593307 1965 742806 SGTC_2786 7743617 45.45 µM 0.236074530139632 0.416943559925672 no 1392 0.406687418705616 1805 583674 SGTC_870 0573-2213 57.6 µM 0.232369472589561 0.418236492665221 no 1393 0.408125528696182 1964 3916321 SGTC_2378 9074213 121.43 µM 0.231229689249036 0.418634414794932 no 1394 0.408568183111114 1912 657714 SGTC_2782 7736369 71.43 µM 0.230190618204202 0.418997248734822 no 1395 0.408971825860695 1860 2950836 YOL077C BRX1 SGTC_2089 5281248 129.67 µM 0.22971644853227 0.419162847287814 no 1396 0.409156056299617 1851 2737878 SGTC_2202 7226349 200 µM 0.229562660132614 0.419216559275341 no 1397 0.409215812438764 1907 844334 SGTC_2235 salicylic acid 500 µM 0.229269005795911 0.419319124885752 no 1398 0.409329920853316 2008 338 A COX inhibitor and kinase inhibitor. SGTC_3015 9080845 49.47 µM 0.228532538946701 0.419576377171862 no 1399 0.409616131448663 1989 5296973 SGTC_2830 7992007 71.43 µM 0.226698170878394 0.420217282151704 no 1400 0.410329224759929 1830 1952075 SGTC_1335 1486-0900 202 µM 0.225926379314033 0.420486999696713 no 1401 0.410629340241614 1901 X1335 SGTC_1004 4084-0029 199 µM 0.223956599426139 0.421175546480359 no 1402 0.411395537044786 2025 716894 YLR208W SEC13 SGTC_1752 st044819 83.042 µM 0.223775602065003 0.421238827176347 no 1403 0.411465957649559 1866 441209 YML126C ERG13 SGTC_463 ikarugamyin 104 µM 0.223658853989116 0.42127964597527 no 1404 0.411511382311993 1980 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2692 st077426 47.7 µM 0.223112663896518 0.421470622439977 no 1405 0.411723911200796 2006 25238571 SGTC_1458 k015-0034 6.33 µM 0.22034156097791 0.422439827871929 no 1406 0.412802577222807 1826 3598957 SGTC_1135 dihydrocapsaicin 536.708 nM 0.217996621114771 0.423260348131948 no 1407 0.413715872040382 1793 107982 A Capsaicinoid. SGTC_1058 3448-5425 97.3 µM 0.215192023610007 0.424242144621404 no 1408 0.414808804748205 2025 7279705 SGTC_244 nsc-207895 1.295 µM 0.214629196974186 0.424439228400708 no 1409 0.415028214242421 1903 42640 SGTC_2908 7930301 100 µM 0.214316679096236 0.424548670267911 no 1410 0.415150056083526 1947 2223178 SGTC_715 0868-0130 184 µM 0.214015402871339 0.424654180883489 no 1411 0.415267522849552 2065 2876258 SGTC_1273 0849-0096 14.1 µM 0.213573717605721 0.424808874218171 no 1412 0.415439748400719 1909 5286025 SGTC_1321 1326-2144 215 µM 0.213326979989466 0.424895295240184 no 1413 0.415535965436422 2024 3513030 SGTC_205 1486-1330 71.903 µM 0.212337871574189 0.425241771359886 no 1414 0.415921725875972 1940 4118834 SGTC_2006 4011487 200 µM 0.209590582571803 0.426204425070221 no 1415 0.416993615207584 2010 45595294 SGTC_2869 9037858 32.47 µM 0.20787804940814 0.42680472189654 no 1416 0.41766209440528 2059 27187042 SGTC_441 propafenone 146 µM 0.206431094818158 0.427312057290684 no 1417 0.418227091855858 1962 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_981 1488-1094 54.9 µM 0.205875425857906 0.427506919543918 no 1418 0.418444110787605 1943 3449522 SGTC_2376 9072922 81.32 µM 0.205239939933414 0.427729793724389 no 1419 0.418692333012199 1985 17087968 SGTC_2334 9017922 200 µM 0.204610881456184 0.427950436419341 no 1420 0.418938076549292 2019 3163164 SGTC_2546 rhodinyl acetate 100 µM 0.204035402936141 0.428152305642982 no 1421 0.419162916627018 2073 6708682 SGTC_2265 7929201 200 µM 0.203589845286332 0.428308613494586 no 1422 0.419337014618349 1937 1265108 SGTC_1178 0988-0033 191 µM 0.203172068462844 0.428455185662593 no 1423 0.419500271827579 1986 5392207 SGTC_1679 SEC14.276 6.7 µM 0.20228031855718 0.428768078798128 no 1424 0.419848792727231 2072 1005053 YMR079W SEC14 SGTC_1799 st045822 46.1415 µM 0.201876327984156 0.428909843914404 no 1425 0.420006704295129 2055 3674992 SGTC_1210 3013-0140 750 nM 0.201690367543671 0.428975102737208 no 1426 0.420079396719216 2073 905973 SGTC_3222 9128301 49.47 µM 0.201522992701637 0.429033841003631 no 1427 0.420144826315533 1939 4911358 SGTC_364 0083-0097 67.7 µM 0.201340045883945 0.429098045872613 no 1428 0.42021634577935 1934 5207356 SGTC_3137 9097352 49.47 µM 0.200860624335372 0.429266306930357 no 1429 0.420403778705695 2022 44120435 SGTC_838 0109-0203 71.4 µM 0.19930275180247 0.429813157089095 no 1430 0.421012963363956 1955 759422 SGTC_655 k060-0012 42 µM 0.196858257272768 0.430671503658835 no 1431 0.421969230140095 1947 5994525 SGTC_1312 1218-2183 165 µM 0.196592309193814 0.430764907060532 no 1432 0.422073294769557 2063 6744073 SGTC_907 3448-6986 75.5 µM 0.195988851462217 0.430976861300959 no 1433 0.422309446011522 2045 590582 SGTC_894 0960-0238 55.9 µM 0.195601958049468 0.431112761479553 no 1434 0.422460863792281 2061 6741907 YDL195W SEC31 SGTC_67 0335-0847 266 µM 0.19526090573571 0.431232566278478 no 1435 0.422594350328191 2097 4552207 YOR254C SEC63 SGTC_41 0478-0632 82.643 µM 0.193804856079131 0.431744118192237 no 1436 0.423164342253095 2120 3750424 SGTC_1657 st012939 43.4 µM 0.192516624096687 0.432196806434881 no 1437 0.423668773658733 2066 24207257 SGTC_3113 9123498 49.47 µM 0.192481665263298 0.43220909230804 no 1438 0.423682464193303 2093 8897275 SGTC_2289 7946404 165.07 µM 0.192443182685706 0.432222616635687 no 1439 0.423697534798686 1946 1246120 YPR165W RHO1 SGTC_148 3253-0744 288.01 µM 0.192032716850275 0.43236687579999 no 1440 0.423858288991255 2092 6893655 SGTC_676 falcarinol 140 µM 0.190412107970481 0.432936530425287 no 1441 0.424493105227453 2083 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_95 0471-0001 561.058 µM 0.189781963067544 0.433158068184343 no 1442 0.424739995206144 1870 4015405 SGTC_1812 st052057 4.327 µM 0.189727118389164 0.433177350723819 no 1443 0.424761484680158 1980 3645418 SGTC_2728 chlorpromazine 9.18 µM 0.189335710994474 0.433314968117875 no 1444 0.424914854070836 2053 2726 A thorazine and dopamine antagonist. SGTC_2402 5553605 200 µM 0.18914850794181 0.433380790879243 no 1445 0.424988211886231 2033 6758546 SGTC_512 prima-1 270 µM 0.189049928113801 0.433415453431342 no 1446 0.425026842646832 2042 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.18842453288101 0.433635366271512 no 1447 0.425271934831158 1952 6708514 SGTC_1231 0242-0792 125 µM 0.186935977164177 0.434158881821634 no 1448 0.425855415341544 1924 3707635 SGTC_1783 st039459 87.517 µM 0.184934659920058 0.43486291420082 no 1449 0.426640142586809 2083 729761 SGTC_1949 st076024 69.1 µM 0.184623835559993 0.434972275981398 no 1450 0.426762044626851 1911 2921930 SGTC_1227 3909-8010 46.6 µM 0.184407386189128 0.435048435398554 no 1451 0.426846937922863 1992 15982272 SGTC_747 3448-8087 38.7 µM 0.183729714807225 0.435286894985525 no 1452 0.427112748334286 1938 5168703 SGTC_427 1354-0053 47.3 µM 0.181060896142861 0.436226229232873 no 1453 0.428159888799778 2051 6813657 SGTC_2629 bisabolol 100 µM 0.178550260042692 0.437110217105339 no 1454 0.429145426731892 2028 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_709 3807-1509 243 µM 0.178039219297532 0.437290191721831 no 1455 0.42934608760252 2081 1886677 YPL242C IQG1 SGTC_2627 acetyl isogambogic acid 100 µM 0.177869844213375 0.437349843873389 no 1456 0.429412596999554 1934 6857789 A caspase activator and apoptosis inducer. SGTC_3179 9107801 49.47 µM 0.17417945255382 0.438649912886786 no 1457 0.430862216591631 2013 4818259 SGTC_191 3914-0123 66.505 µM 0.173371629552414 0.43893458551334 no 1458 0.431179661868751 1979 3144412 SGTC_2981 9013952 38.96 µM 0.17178432698812 0.439494034568679 no 1459 0.431803543801254 1871 2996344 SGTC_57 miconazole 162.5 nM 0.171579521254267 0.439566227726916 no 1460 0.431884054172676 2013 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1878 temozolomide 1 mM 0.170791422543921 0.439844047927679 no 1461 0.4321938868985 2137 5394 DNA alkylating agent. SGTC_2697 mebhydrolin 72.4 µM 0.16827028906243 0.440732995071888 no 1462 0.433185323226112 2102 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2490 carminic acid 95.39 µM 0.167569618499799 0.440980103498301 no 1463 0.433460937054815 2027 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2400 5203494 178.7 µM 0.165786211145819 0.441609168719373 no 1464 0.43416259893201 2080 6777674 SGTC_2867 9039098 71.43 µM 0.164136028738709 0.442191372468488 no 1465 0.43481202979337 2014 6463460 SGTC_1946 st076057 65.1 µM 0.162922348125939 0.442619653031206 no 1466 0.435289787330668 2035 953009 SGTC_2433 5607874 27.82 µM 0.16219288210885 0.44287709746435 no 1467 0.435576982420152 2032 2252428 SGTC_2809 7964133 12.99 µM 0.161028893571345 0.443287944257662 no 1468 0.436035321909671 2010 1253665 SGTC_2572 astragaloside iv 100 µM 0.159608896844568 0.443789235414904 no 1469 0.436594585083516 1992 45006101 An anti-inflammatory agent. SGTC_1372 2752-0194 270 µM 0.158737359390298 0.444096952569163 no 1470 0.436937901402309 2081 823334 SGTC_3188 9110789 49.47 µM 0.158305566919676 0.444249419730931 no 1471 0.437108010845404 2119 849217 SGTC_1980 st071811 45.7 µM 0.158254653774656 0.44426739785291 no 1472 0.437128069411758 2084 4974850 SGTC_1804 st050076 49.1 µM 0.157985204506645 0.444362545952176 no 1473 0.437234228694714 2070 3895976 SGTC_1108 betulinic acid 729.144 nM 0.157886186598221 0.444397512025802 no 1474 0.437273241516325 2002 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1611 st001856 99.4 µM 0.151313990431127 0.446719298162499 no 1475 0.439864016791687 1972 647478 SGTC_1763 st044482 94.5 µM 0.151184327516431 0.446765123346065 no 1476 0.439915156508435 2082 88505 SGTC_1351 1496-0003 46.5 µM 0.151149999519373 0.446777255590699 no 1477 0.439928695813926 2131 3891978 SGTC_1717 st033143 58.0435 µM 0.15104152304098 0.446815593813818 no 1478 0.439971480483986 2127 674616 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.150246919309382 0.447096441212299 no 1479 0.440284904870602 2128 88881 An O-methylated flavonoid and antioxidant. SGTC_2290 7904846 200 µM 0.148773810095571 0.447617171938471 no 1480 0.44086605856803 2004 2962154 SGTC_1852 st056254 31.4 µM 0.14868118722003 0.447649916310251 no 1481 0.440902603323227 2056 442583 SGTC_2712 st079126 47.7 µM 0.147776480431957 0.447969770232449 no 1482 0.441259585708638 2075 3152970 SGTC_315 k915-0449 187 µM 0.147030146147177 0.44823365793614 no 1483 0.441554112855536 2069 20970215 YNL149C PGA2 SGTC_389 tpck 16.7 µM 0.145426807047146 0.44880064137757 no 1484 0.44218695033926 2043 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_432 NS 1619 61.3 µM 0.144994399429422 0.448953570190269 no 1485 0.442357646835275 2018 4552 A K+/calcium channel activator. SGTC_2155 5570423 76 µM 0.144205403104334 0.449232632608805 no 1486 0.44266913724141 2015 797402 SGTC_1561 5-methoxyflavone 52.9 µM 0.142597179569732 0.44980152751613 no 1487 0.443304162547494 2162 94525 SGTC_2676 harmalol 100 µM 0.14241801104336 0.449864913213333 no 1488 0.443374918318994 2127 5459187 A monoamine oxidase inhibitor SGTC_2434 5670830 169.91 µM 0.142113759679612 0.449972553266368 no 1489 0.443495074918287 2047 1549830 SGTC_1973 st070275 50.2 µM 0.139644614036675 0.450846239341947 no 1490 0.444470394527306 2181 17118334 SGTC_3264 9137442 49.47 µM 0.137999226301903 0.451428578249284 no 1491 0.445120514509508 2157 17015726 SGTC_1059 3448-6867 171 µM 0.136913484902314 0.451812903340846 no 1492 0.445549589902175 2204 3934407 SGTC_3097 9117246 49.47 µM 0.136379467636615 0.452001948586381 no 1493 0.445760652233 2176 16423892 SGTC_2610 ononetin 44.17 µM 0.136357245192915 0.452009815698016 no 1494 0.445769435654798 2041 259632 SGTC_1193 1488-0126 41.5 µM 0.135743271838572 0.452227179834837 no 1495 0.446012119159669 2130 1384710 SGTC_1287 0971-0001 34.6 µM 0.133427485718034 0.453047162718812 no 1496 0.446927654642362 2083 4665869 SGTC_1102 cgs 12066b 26.1 µM 0.1332777049354 0.453100204634215 no 1497 0.446986879585181 2082 6438352 A 5-HT1B full agonist. SGTC_38 0929-0051 58.268 µM 0.132507100014699 0.453373112402739 no 1498 0.447291603772891 2173 1379719 SGTC_1665 st014639 11.4 µM 0.131738444934686 0.453645351578677 no 1499 0.447595587924581 2169 981133 YIL048W NEO1 SGTC_1190 1486-1332 13 µM 0.131027853372342 0.453897045431165 no 1500 0.447876636772351 2152 4150046 SGTC_162 k030-0015 37.8 µM 0.130864615114281 0.453954867574469 no 1501 0.447941203475515 2149 1809920 YMR134W ERG29 SGTC_701 4424-0219 185 µM 0.130174160945895 0.454199450554141 no 1502 0.448214318594635 2184 2911779 SGTC_2626 ethyl orsellinate 100 µM 0.126173258155966 0.455617049074071 no 1503 0.449797389535382 2104 75653 A natural product. SGTC_298 1391-0729 10 µM 0.125568878944444 0.455831242098591 no 1504 0.450036599462715 2092 3237558 SGTC_1028 k015-0029 4.8 µM 0.125324475516292 0.455917862739754 no 1505 0.450133338138986 2185 4588309 SGTC_1892 st058411 7.36 µM 0.125181745704744 0.45596844952899 no 1506 0.450189834188094 2180 3934738 SGTC_3288 9119690 36.221 µM 0.124933607566381 0.456056397197527 no 1507 0.450288055906275 2064 17595618 YKL019W RAM2 SGTC_2483 5729050 27.16 µM 0.124424853477334 0.456236721777024 no 1508 0.450489448010501 2177 2865180 SGTC_1126 isoteolin 1.0172 µM 0.123341954227551 0.456620578343132 no 1509 0.450918159889966 2156 133323 SGTC_2649 anisomycin 9.56 µM 0.121830672067689 0.457156351897277 no 1510 0.451516561042679 2107 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3298 9116858 71.43 µM 0.120003042856597 0.45780437946432 no 1511 0.452240368764351 2154 2506942 SGTC_811 0416-0114 265 µM 0.117153919781318 0.458814824087027 no 1512 0.453369041033972 2061 6612453 SGTC_2226 7298446 200 µM 0.117050996527893 0.458851330951979 no 1513 0.45340982090374 2195 3283010 SGTC_618 k072-0232 33.2 µM 0.116950364997961 0.458887025278435 no 1514 0.453449693230331 2122 5872756 YGL099W LSG1 SGTC_1587 estradiol valerate 56.1 µM 0.116775675311967 0.458948989057377 no 1515 0.453518910068544 2198 13791 A steroid. SGTC_2756 carbadox 75.1 µM 0.116379622068735 0.459089475888991 no 1516 0.453675842437426 2088 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2014 4013930 200 µM 0.115435412929269 0.459424423531667 no 1517 0.454050005553471 2224 64556 SGTC_1476 4112-3294 3.34 µM 0.11506616863029 0.459555416668585 no 1518 0.454196337635108 2159 704369 SGTC_1749 st037932 54.2 µM 0.113572422613078 0.460085382787501 no 1519 0.454788374718472 2110 594497 SGTC_2164 5685496 200 µM 0.113194441325976 0.46021949804109 no 1520 0.45493820126207 2192 759046 SGTC_1757 st041620 31.8375 µM 0.113033340282337 0.460276661261446 no 1521 0.455002061432619 2086 5289815 SGTC_209 4077-0173 175.592 µM 0.111835645032492 0.46070166317368 no 1522 0.455476862074244 2148 15993494 SGTC_3248 9135562 49.47 µM 0.110986996862849 0.461002833005773 no 1523 0.455813329011942 2109 17650701 SGTC_2513 baicalein 25.65 µM 0.110000273781261 0.461353031230285 no 1524 0.456204578893568 2096 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1237 0330-0133 46.1 µM 0.109969976825711 0.461363784408699 no 1525 0.456216592745761 2152 X1237 YHR072W ERG7 SGTC_671 0560-0003 407 µM 0.109643719429547 0.461479583442172 no 1526 0.456345968283323 2170 3238678 SGTC_234 nsc-17383 10.7 µM 0.108537620606688 0.461872197025523 no 1527 0.456784619919661 2201 408974 SGTC_1185 1319-0113 81.3 µM 0.108427802158045 0.46191117949571 no 1528 0.456828174102798 2134 4672763 SGTC_2178 5812956 200 µM 0.107694597929679 0.462171455797921 no 1529 0.45711897740935 2231 5403383 SGTC_443 clozapine 122 µM 0.107321670810079 0.462303845451535 no 1530 0.457266896504859 2229 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2033 5192550 145 µM 0.106835772977954 0.462476346130877 no 1531 0.457459633571406 2125 182073 SGTC_3281 9140613 49.47 µM 0.106249409270118 0.462684523027174 no 1532 0.457692234922716 2017 16013766 SGTC_1014 4130-3005 69.3 µM 0.105677838843082 0.46288745769818 no 1533 0.45791898195845 2127 743608 SGTC_3019 9081971 49.47 µM 0.105565003055457 0.46292752090972 no 1534 0.457963746532953 2202 16451803 SGTC_2933 9026794 32.47 µM 0.104803031967163 0.463198074410349 no 1535 0.458266052069753 2173 17586027 SGTC_428 3448-4153 16.5 µM 0.104325772051428 0.463367544034255 no 1536 0.458455413182118 2060 3834874 SGTC_332 4112-0506 40.9 µM 0.103291060508391 0.463734981245895 no 1537 0.458865985175601 2150 2790355 SGTC_1969 st069479 40.1 µM 0.0995022647783404 0.465080685086875 no 1538 0.460369744896159 2219 3895485 SGTC_2054 5233173 129 µM 0.0988676996894231 0.46530610928239 no 1539 0.460621657567394 2160 6889 SGTC_1023 4482-3888 16 µM 0.0987926178245491 0.465332782255117 no 1540 0.460651464971313 2232 3303168 SGTC_2888 9058547 12.99 µM 0.0976615110307003 0.465734628836094 no 1541 0.461100539576209 2182 16476514 SGTC_56 0957-0365 83.25 µM 0.0975541543390695 0.465772771105709 no 1542 0.461143165162021 2233 6752360 SGTC_1226 3909-7979 35.4 µM 0.0969855198872226 0.465974803882952 no 1543 0.46136894684568 2218 6615510 SGTC_85 0868-0259 160.055 µM 0.0958904657834416 0.466363895403811 no 1544 0.461803783444202 2172 83173 SGTC_2700 st077718 96.8 µM 0.0956388044190642 0.466453319563423 no 1545 0.461903722486508 2121 904970 SGTC_2931 9014674 55.67 µM 0.095494697544837 0.466504526581743 no 1546 0.461960950880313 2194 2996810 SGTC_2492 derrusnin 100 µM 0.0951538474267695 0.466625646660946 no 1547 0.462096314000651 2146 1715307 Part of coumarin class of compounds. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0951018646284483 0.466644118866163 no 1548 0.462116958515813 2191 15053 SGTC_1865 st057639 52.2 µM 0.0941662757095887 0.466976594754465 no 1549 0.462488536893352 2248 688818 SGTC_2201 6605497 169.863 µM 0.093457298239596 0.467228556144227 no 1550 0.462770136117526 2215 670741 SGTC_607 4491-0986 66.8 µM 0.0926669794112104 0.467509440670504 no 1551 0.463084065355717 2230 698981 YDR232W HEM1 SGTC_1337 1486-1011 40.3 µM 0.09241822254409 0.467597853856574 no 1552 0.463182880945132 2259 X1337 SGTC_73 0327-0325 16.231 µM 0.0918814622840869 0.46778863467225 no 1553 0.46339611005265 2258 53298 SGTC_1689 st020265 53.493 µM 0.0912391432702596 0.468016943979496 no 1554 0.463651286406991 2235 5758320 YPR016C TIF6 SGTC_305 1682-2595 20.8 µM 0.0911929248815861 0.468033372497502 no 1555 0.463669648328304 2173 226033 SGTC_1743 st037606 46.3785 µM 0.090951162110762 0.468119308964005 no 1556 0.463765698566136 2185 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_143 4032-1194 15.74 µM 0.0903593342343367 0.468329685070196 no 1557 0.464000835515731 2195 1806963 SGTC_2251 lansoprazole 556 µM 0.0900277684064078 0.468447550112623 no 1558 0.464132574212375 2047 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_292 k038-0015 474 µM 0.0898374406677151 0.468515209079873 no 1559 0.464208197559148 2210 46368540 SGTC_2396 5342950 42.78 µM 0.0887323047586717 0.468908088033171 no 1560 0.464647329151552 2146 1886677 SGTC_3118 9124250 49.47 µM 0.0879801915273953 0.46917548376084 no 1561 0.464946209976819 2136 1504786 SGTC_2214 7179297 48.276 µM 0.0877731480339548 0.469249095529273 no 1562 0.465028490069806 2255 769744 SGTC_2851 9015922 71.43 µM 0.0862214277373672 0.46980082388944 no 1563 0.465645198632382 2225 2996893 SGTC_137 0438-0332 85.389 µM 0.0833060262326701 0.470837577574241 no 1564 0.466804104356093 2241 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2204 7233102 200 µM 0.0829990999705484 0.470946736062108 no 1565 0.466926127632741 2210 2172480 SGTC_940 3232-1287 54.8 µM 0.0821725606898715 0.471240706027122 no 1566 0.467254746516577 2282 1585493 YIL048W NEO1 SGTC_677 0929-0063 136 µM 0.0809199014610855 0.471686261181651 no 1567 0.4677528263945 2262 1539583 SGTC_1988 st071872 53.4 µM 0.0805869871906857 0.47180468058989 no 1568 0.467885207630766 2276 16414116 SGTC_1133 3473-0247 50 µM 0.0805784098901479 0.471807731615108 no 1569 0.467888618386612 2051 711311 SGTC_2505 galangin 7.89 µM 0.0802467896989635 0.471925693254341 no 1570 0.468020488662472 2158 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_674 0498-0004 451 µM 0.0795177788734515 0.472185020582846 no 1571 0.468310395446473 2151 4231473 SGTC_777 1315-0167 517 µM 0.0794377490930561 0.472213489891559 no 1572 0.468342222030919 2085 4221767 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0786889032048885 0.472479886645639 no 1573 0.46864003603503 2223 390807 SGTC_112 phenothiazine 287.218 µM 0.0786640258322121 0.472488736811135 no 1574 0.468649930001622 2273 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1195 1502-0147 41.1 µM 0.0771350425325166 0.473032700990588 no 1575 0.469258058061608 2256 817940 SGTC_1275 0867-0008 21.1 µM 0.0735577651373459 0.474305578527388 no 1576 0.470681139294693 2211 3422836 SGTC_311 1315-0136 58 µM 0.0735214892533127 0.474318487686492 no 1577 0.470695572198653 2262 6759207 SGTC_1960 st011366 51.8 µM 0.073237816423571 0.474419436608464 no 1578 0.470808437010014 2279 3972846 SGTC_33 0986-0033 35.816 µM 0.0726411433323398 0.474631776379782 no 1579 0.471045842770248 2282 2848082 SGTC_2971 9092186 9.93 µM 0.0717994247021247 0.474931333452273 no 1580 0.471380765330851 2067 25236400 SGTC_2172 5754775 163.918 µM 0.07130323506635 0.475107927752546 no 1581 0.471578210287311 2203 2263357 SGTC_3089 9117425 49.47 µM 0.0705426453156792 0.475378631753007 no 1582 0.47188087950887 2123 9401657 SGTC_3315 9136395 68.55 µM 0.0688611810591428 0.475977127388058 no 1583 0.472550059082629 2278 16876844 SGTC_816 0325-0417 81.3 µM 0.0684689766597492 0.476116735358846 no 1584 0.472706157571165 2195 68101 SGTC_787 4152-0075 138 µM 0.0683480588068699 0.47615977752848 no 1585 0.472754284073851 2146 9566539 SGTC_2321 7390090 138.78 µM 0.0678377230537184 0.476341440759966 no 1586 0.472957407130082 2186 649046 SGTC_2207 7258803 200 µM 0.0666736096543448 0.476755846297847 no 1587 0.473420771997329 2273 3666799 SGTC_227 fluconazole 33.516 µM 0.0663946237455081 0.476855164519303 no 1588 0.473531825194889 2217 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_956 1185-0240 191 µM 0.0660577791463891 0.476975082191769 no 1589 0.473665912376978 2243 1416193 SGTC_2427 5545055 42.75 µM 0.0652021543531706 0.477279696495748 no 1590 0.474006522927668 2234 5372858 SGTC_1016 4226-1401 38 µM 0.063455262222186 0.477901655373664 no 1591 0.474701991492052 2295 2901613 SGTC_1459 k035-0031 35.7 µM 0.0634012408920252 0.477920889851696 no 1592 0.474723499576099 2275 3877128 YMR208W ERG12 SGTC_1695 st026914 34.495 µM 0.0628942241070777 0.478101417399938 no 1593 0.47492536711767 2250 3289191 SGTC_814 3342-0569 96 µM 0.0621670090660977 0.478360356205758 no 1594 0.475214917302471 2296 4346283 SGTC_1438 4092-1045 4 µM 0.0605380535583797 0.478940409912833 no 1595 0.475863554527874 2299 1351342 SGTC_2053 5265679 138 µM 0.0604707205450723 0.478964387450208 no 1596 0.475890367390793 2292 764595 SGTC_3061 glucosamine 200 µM 0.0598324432465694 0.479191684147854 no 1597 0.476144542940673 2292 91431 and experimental redox chemotherapeutic SGTC_3006 9075424 71.4286 µM 0.0579753465692842 0.479853052394032 no 1598 0.476884133037987 2245 7465181 SGTC_2022 5136654 200 µM 0.0571129354821944 0.480160202014271 no 1599 0.477227616109461 2249 1713771 SGTC_2293 7624732 200 µM 0.0567279094759453 0.48029733369432 no 1600 0.477380970630828 2300 894453 SGTC_2352 9027995 87.8 µM 0.055303968742338 0.48080450758183 no 1601 0.477948150204106 2255 2997347 SGTC_1615 st002656 86.5 µM 0.0550574846354037 0.48089230254752 no 1602 0.478046333541874 2314 1584458 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0537799767372763 0.481347351761147 no 1603 0.47855523133876 2264 5379071 SGTC_1867 st057372 64 µM 0.0510210003580102 0.482330183236291 no 1604 0.479654393237054 2310 688837 SGTC_999 SEC7.066 22.7 µM 0.0505977273680743 0.482480975626894 no 1605 0.479823036902557 2272 740511 YDR170C SEC7 SGTC_2821 7996764 71.43 µM 0.0504314269328116 0.482540221389223 no 1606 0.479889296585242 2267 2987135 SGTC_3123 9126162 49.47 µM 0.0501803657322744 0.482629664532237 no 1607 0.479989328857733 2325 25239884 SGTC_1447 4239-0816 81.9 µM 0.0501329240483835 0.482646566219949 no 1608 0.480008231559669 2225 1341554 SGTC_2926 9010726 65.15 µM 0.0464309116393686 0.483965547776005 no 1609 0.481483399574132 2272 2994293 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0453860879969723 0.484337837984962 no 1610 0.481899784865639 2333 1241132 A phosphatase inhibitor. SGTC_172 1112-0046 2.638 µM 0.0447637451644129 0.484559596887517 no 1611 0.482147811638465 2291 2802135 YIL048W NEO1 SGTC_904 1141-0088 396 µM 0.0440805109985151 0.484803058645072 no 1612 0.482420113826358 2235 1378119 SGTC_2318 6029776 164 µM 0.0438938727247977 0.484869565796108 no 1613 0.482494499726319 2311 818325 SGTC_1817 st052116 64.4 µM 0.0434359349712361 0.485032750264479 no 1614 0.482677016378153 2310 4361398 SGTC_888 0916-0002 6.97 µM 0.04341902891294 0.48503877472558 no 1615 0.482683754562679 2319 2802138 YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0433895760605517 0.485049270235434 no 1616 0.482695493487888 2326 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_864 0469-0573 172 µM 0.0428597181059871 0.485238086626173 no 1617 0.482906679759502 2298 689425 SGTC_1206 3978-0017 132 µM 0.0416273700430136 0.485677250096 no 1618 0.483397877004433 2244 3873677 SGTC_1740 st038286 13.222 µM 0.0416230239404502 0.485678798917967 no 1619 0.483399609347072 2306 716786 SGTC_2370 9071495 200 µM 0.0383749150472106 0.486836387318973 no 1620 0.484694380569216 2203 21791103 SGTC_288 1315-0019 35.1 µM 0.0375460504544192 0.487131803214757 no 1621 0.485024811529551 2305 6811474 SGTC_3347 9188721 44.724 µM 0.0368705712840735 0.487372556192268 no 1622 0.485294102249582 2290 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2123 5259487 200 µM 0.0363113290276218 0.48757188372007 no 1623 0.485517058320116 2334 2173474 SGTC_1015 4130-4525 82 µM 0.0339080213746197 0.488428515675713 no 1624 0.48647524836791 2328 1363237 SGTC_301 4119-0100 24.5 µM 0.0322834239869091 0.48900761560755 no 1625 0.487123014028576 2336 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1356 1502-0781 85.8 µM 0.0320781410390033 0.489080791929505 no 1626 0.487204867680888 2345 567702 SGTC_2064 5220758 200 µM 0.0316369340019317 0.489238068328873 no 1627 0.487380794523991 2307 788518 SGTC_2880 9042983 58.44 µM 0.0309477734589015 0.489483735675456 no 1628 0.487655595220226 2315 6464714 SGTC_3116 9124943 49.47 µM 0.0287323779201663 0.490273491639142 no 1629 0.488539016587798 2336 41905195 YPL160W CDC60 SGTC_581 0958-0271 211 µM 0.0279850671453321 0.490539905707495 no 1630 0.488837030587467 2356 4591145 SGTC_32 0928-0142 34.1 µM 0.0258913722144291 0.49128632381833 no 1631 0.489671990858409 2367 2244242 SGTC_791 1348-1292 225 µM 0.0251278322858927 0.491558539320533 no 1632 0.489976500117014 2340 5437054 SGTC_2127 5253358 187.912 µM 0.0245318203180026 0.491771030877524 no 1633 0.49021420120205 2361 20612 SGTC_2346 9031566 143.75 µM 0.0235044678013137 0.492137310406376 no 1634 0.490623937340276 2352 4771086 SGTC_1821 st053465 65.6 µM 0.0226876864546344 0.492428520246761 no 1635 0.490949699047335 2339 675086 SGTC_430 0958-0115 16.4 µM 0.0226163206673404 0.492453964728344 no 1636 0.490978162573811 2289 6833180 SGTC_2247 cerulenin 830 nM 0.0225301409465322 0.492484690953362 no 1637 0.491012534549895 2361 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_201 4262-0159 12.803 µM 0.0222126527169763 0.492597887511964 no 1638 0.491139162336399 2361 1341029 SGTC_2355 9061122 103.12 µM 0.0220225117171388 0.492665680253933 no 1639 0.4912149990689 2354 5302957 SGTC_3278 9139605 49.47 µM 0.0218675346725889 0.492720935820131 no 1640 0.49127681107877 2343 7958859 SGTC_2311 7694451 200 µM 0.0216013277343297 0.492815849654465 no 1641 0.491382987200473 2347 2163142 SGTC_2453 5731132 22.18 µM 0.0215633240786061 0.492829399570077 no 1642 0.491398144934927 2359 1362040 SGTC_2852 9023854 51.95 µM 0.0212074411785291 0.492956287322075 no 1643 0.491540089208166 2359 19798528 SGTC_1984 st072354 53.1 µM 0.0208488080986818 0.493084156353887 no 1644 0.491683131477245 2335 5762938 SGTC_990 3985-0011 41.3 µM 0.02069983604686 0.493137271886986 no 1645 0.491742549904198 2349 5399565 YGL099W LSG1 SGTC_1380 2291-0730 164 µM 0.0203983484684707 0.49324476673967 no 1646 0.491862800654244 2351 2999191 SGTC_1360 1598-0022 39.8 µM 0.0199513076959527 0.493404159222026 no 1647 0.492041107826666 2361 761525 SGTC_1052 3253-3998 198 µM 0.0193491245011858 0.493618869428037 no 1648 0.492281297783108 2362 5450317 SGTC_1992 st073643 23.3 µM 0.0181526558441927 0.494045479304937 no 1649 0.492758535784264 2364 3161292 SGTC_2774 tamoxifen 10.92 µM 0.0176320062056769 0.494231122995266 no 1650 0.492966211691121 2380 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3277 9138724 49.47 µM 0.0158519712345774 0.494865824381162 no 1651 0.493676243292121 2300 15943418 SGTC_1826 st055655 41.6 µM 0.01578519522614 0.494889634752232 no 1652 0.493702879732404 2321 676168 SGTC_2925 9010536 32.5 µM 0.0155360454542963 0.494978474431981 no 1653 0.493802263922304 2358 2994177 SGTC_590 k048-0076 22.4 µM 0.015389513248807 0.495030723740341 no 1654 0.493860714826311 2376 6832814 SGTC_497 capsazepine 133 µM 0.0153128785708226 0.495058049568753 no 1655 0.493891284037326 2372 2733484 A calcium channel blocker. SGTC_1939 st074455 53.6 µM 0.0153066723457134 0.495060262539758 no 1656 0.493893759672775 2380 1644229 SGTC_2151 5563267 85.4165 µM 0.0151156167100964 0.495128387854903 no 1657 0.493969971026256 2359 5310824 SGTC_978 1416-0512 87.4 µM 0.0149314676886447 0.495194050591171 no 1658 0.494043427566415 2360 6814003 SGTC_285 1486-1325 46 µM 0.0143975886232065 0.495384418665632 no 1659 0.494256391595694 2371 22310230 SGTC_3075 9116269 49.47 µM 0.0143706869160237 0.495394011177442 no 1660 0.494267122713894 2357 17015205 YNL244C SUI1 SGTC_2173 5763948 167 µM 0.0132426453721524 0.495796246411595 no 1661 0.494717103265341 2374 2867177 SGTC_72 0744-0168 198.391 µM 0.0131467998812479 0.495830423044881 no 1662 0.49475533675565 2334 677577 SGTC_1182 1222-0449 220 µM 0.0129976314413519 0.495883613662884 no 1663 0.494814841268804 2370 658318 SGTC_580 1123-0028 41 µM 0.0126692365223598 0.496000713278414 no 1664 0.494945841097985 2380 1677248 YPR107C YTH1 SGTC_1453 4237-0541 195 µM 0.0124621095266302 0.496074571150654 no 1665 0.495028466290489 2376 739892 SGTC_235 0330-0087 5 mM 0.0114959522902333 0.496419087698138 no 1666 0.495413879592761 2378 46494818 YHR062C RPP1 SGTC_2184 6075246 200 µM 0.0107001420569454 0.49670286318792 no 1667 0.495731342382603 2369 2267320 SGTC_107 0358-0022 2.6945 µM 0.0101928909157957 0.496883743170428 no 1668 0.495933695265763 2354 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_527 4476-4215 268 µM 0.00982540730518696 0.497014784044935 no 1669 0.496080292671092 2321 4418754 SGTC_250 brefeldin a 552.239 µM 0.00858185786696973 0.49745822328557 no 1670 0.496576376076526 2384 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1764 st044502 93.5 µM 0.00777166732174564 0.497747132124052 no 1671 0.496899584526409 2382 8407 SGTC_2593 nobiletin 86.24 µM 0.00675002346635473 0.498111445544832 no 1672 0.497307150694551 2386 72344 An anti-infammatory. SGTC_2934 9036370 36.88 µM 0.005715261046179 0.498480438588555 no 1673 0.497719953137809 2392 6462800 SGTC_401 neomycin 50 µM 0.00547145348028113 0.498567379805203 no 1674 0.497817216762397 2374 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2307 7538926 6.34 µM 0.00406126423506366 0.499070251248906 no 1675 0.498379794438661 2392 96582 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.00331273924542718 0.499337174827725 no 1676 0.498678410668294 2400 688803 SGTC_2460 5552655 174.22 µM 0.00199306525404685 0.499807770459259 no 1677 0.49920488252897 2397 5401989 SGTC_351 caspofungin 25 nM 0.00163716851834706 0.499934683277609 no 1678 0.499346864549658 2398 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_276 colchicine 750 µM 0.00127083819202368 0.499934683277609 no 1679 0.49949300905012 2397 2833 A microtubule depolymerizer. SGTC_1041 0206-0046 107 µM 0.00108225575539967 0.499867434756603 no 1680 0.499568242505248 2396 50494 SGTC_1507 4075-3230 155 µM 0.000987671665847129 0.499833706059477 no 1681 0.4996059760774 2387 659771 SGTC_1002 4049-0206 172 µM -0.000575193981051795 0.49927638834418 no 1682 0.499770530814179 2406 4662749 SGTC_1699 st031318 29.054 µM -0.00148424235878066 0.498952222373937 no 1683 0.499407873186126 2412 5340658 SGTC_1726 st035556 14.5795 µM -0.00154429714166139 0.498930806905382 no 1684 0.499383914821567 2418 5919439 SGTC_2939 9044578 71.43 µM -0.00206716655090585 0.498744352394453 no 1685 0.499175320449546 2409 2653634 SGTC_3324 9138759 60.749 µM -0.0030398691586484 0.498397488745528 no 1686 0.498787269533495 2427 45595710 SGTC_52 0329-0193 875 nM -0.00312776711198622 0.498366144580989 no 1687 0.498752203490297 2413 3739292 SGTC_623 k072-0108 16.9 µM -0.00339307979279807 0.498271534882354 no 1688 0.498646359607286 2412 5382803 SGTC_2229 7354935 190 µM -0.00476243458534939 0.49778322877263 no 1689 0.498100070668242 2413 318112 SGTC_2317 5986382 200 µM -0.00489531455424537 0.497735844504504 no 1690 0.498047059848527 2418 877883 SGTC_1329 1447-1697 50.6 µM -0.00513481226933431 0.497650441013951 no 1691 0.497951515285669 2445 2840515 SGTC_1346 1488-2224 62.4 µM -0.00519552155622319 0.497628792452722 no 1692 0.497927296107393 2406 3722427 SGTC_2242 6630449 61.2675 µM -0.00535427569473309 0.497572181728885 no 1693 0.497863963250529 2465 691249 YDR170C SEC7 SGTC_246 cycloheximide 667 µM -0.00590600181431098 0.497375440064294 no 1694 0.497643859865516 2402 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3083 9117465 49.47 µM -0.00765891757080112 0.496750367066126 no 1695 0.496944563830408 2443 16420915 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.00853293456290012 0.496438703848504 no 1696 0.496595892936401 2424 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1086 cerivastatin 2.18 µM -0.00874717167774097 0.496362309973295 no 1697 0.496510427883488 2421 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3253 9135987 49.47 µM -0.00941050218931696 0.496125776707473 no 1698 0.496245808207292 2426 4182430 SGTC_1626 st003712 1.76 µM -0.0105833243555242 0.495707570086523 no 1699 0.495777943264005 2431 24207035 SGTC_2623 humulene 100 µM -0.0109740995700253 0.495568227921514 no 1700 0.495622055565628 2438 6187145 An anti-inflammatory. SGTC_2185 6113692 200 µM -0.0116885134501171 0.495313484472887 no 1701 0.495337063966049 2445 874150 SGTC_1311 1190-0148 100 µM -0.0120194434732219 0.495195483130106 no 1702 0.495205051263908 2429 1961333 SGTC_215 1287-0124 461.5 µM -0.0133442539544776 0.494723093267241 no 1703 0.494676570887331 2476 5560863 SGTC_840 0245-0196 390 µM -0.0134577772208745 0.494682614423329 no 1704 0.494631285723081 2475 3827528 SGTC_1714 st033236 13.627 µM -0.0136702918281639 0.494606838512843 no 1705 0.49454651245997 2441 2916566 SGTC_969 1313-0238 134 µM -0.0141524759459092 0.494434907807783 no 1706 0.494354167443166 2430 5212874 SGTC_1746 st038117 42 µM -0.0146203314326815 0.494268087200392 no 1707 0.494167539424146 2450 2898218 SGTC_620 0109-0052 432 µM -0.0154647629799728 0.493966995535909 no 1708 0.493830698099119 2431 493037 SGTC_3255 9139072 49.47 µM -0.0155517564521621 0.49393597721715 no 1709 0.493795996898131 2459 17646060 SGTC_3126 9127922 49.47 µM -0.0165991877110614 0.493562508947178 no 1710 0.493378186291203 2469 45595682 SGTC_834 0312-0008 75.7 µM -0.0186866318990257 0.492818234610697 no 1711 0.49254554629675 2440 6385573 YIL048W NEO1 SGTC_3175 9106517 49.47 µM -0.0200170549259752 0.492343887640454 no 1712 0.492014883713848 2454 41468073 SGTC_2800 7887935 81.82 µM -0.0218149397031956 0.491702889905295 no 1713 0.491297788431684 2469 2961002 SGTC_3218 9131285 49.47 µM -0.0220774521310497 0.491609298412755 no 1714 0.491193086342541 2455 17156417 SGTC_1591 genipin 88.4 µM -0.0220915509276576 0.491604271892643 no 1715 0.491187463107936 2498 442424 A DNA cross-linking agent. SGTC_2841 9004761 38.96 µM -0.0223133132440423 0.491525209097839 no 1716 0.491099014546868 2451 2991039 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0234739247727083 0.491111432887501 no 1717 0.490636118884758 2445 5711223 A potent inhibitor of glutathione S-transferases. SGTC_632 0781-2353 4.65 µM -0.0236410253612616 0.491051859684489 no 1718 0.490569473890021 2477 6811515 YHR007C ERG11 SGTC_2397 5161689 200 µM -0.0244222946834269 0.490773331223189 no 1719 0.490257882521173 2467 2259942 SGTC_924 2046-0044 21.3 µM -0.0262981345596158 0.490104598654068 no 1720 0.489509771401907 2450 3623589 SGTC_11 0438-0307 1.3 µM -0.0275347358122606 0.489663768268308 no 1721 0.48901661758561 2464 4011476 SGTC_2954 9074818 52.69 µM -0.0277810103636503 0.48957597645821 no 1722 0.488918405825839 2483 16648742 SGTC_1107 amlodipine 47 µM -0.0281924533238629 0.489429306637751 no 1723 0.488754328104303 2474 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1720 st037298 9.481 µM -0.0284756118773875 0.489328368045871 no 1724 0.488641409521222 2472 597396 SGTC_2351 9026858 72.31 µM -0.030107023465708 0.488746826149264 no 1725 0.487990849677975 2467 1409300 SGTC_2122 5258151 111.688 µM -0.0302019832734743 0.488712976981721 no 1726 0.487952983415431 2485 2173356 SGTC_795 0685-0265 78 µM -0.0314343240904407 0.488273706903201 no 1727 0.487461584001584 2459 302754 SGTC_2834 9001755 58.44 µM -0.0325745422104147 0.487867286781561 no 1728 0.487006935713322 2565 2989575 SGTC_3108 9121785 49.47 µM -0.0337716241576393 0.487440611643592 no 1729 0.486529631837565 2448 17140271 SGTC_3013 9080133 71.4286 µM -0.0346796231022291 0.487116983732776 no 1730 0.486167604780582 2499 17050193 SGTC_2949 9072542 2.23 µM -0.0362153592462578 0.486569637891417 no 1731 0.485555319557915 2503 16457352 SGTC_1027 k015-0025 8.67 µM -0.0362177361486181 0.486568790768086 no 1732 0.485554371932742 2477 3598955 SGTC_333 3486-0131 40.1 µM -0.0367426411667896 0.486381717142399 no 1733 0.485345104423573 2541 6744690 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0379842083915437 0.485939240552538 no 1734 0.484850136410022 2487 6857784 SGTC_1217 1183-1422 255 µM -0.0384612004713321 0.485769252051788 no 1735 0.484659983059184 2511 2849664 SGTC_861 0443-0273 110 µM -0.0385273877677108 0.485745664695436 no 1736 0.484633597704532 2539 6149169 SGTC_1788 fluconazole 20 µM -0.0389773467251741 0.4855853128594 no 1737 0.484454224790321 2548 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3231 9132313 49.47 µM -0.0397560323064503 0.485307818265866 no 1738 0.484143814816653 2498 4905967 SGTC_2950 9072895 21.46 µM -0.0399567645458637 0.485236285905995 no 1739 0.484063797819492 2506 17332245 SGTC_1075 aripiprazole 15.2 µM -0.040550494446746 0.485024708826513 no 1740 0.48382712568646 2479 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2102 5377816 72.7585 µM -0.0407888625090092 0.484939766976415 no 1741 0.483732109200567 2521 1379702 SGTC_1103 duloxetine 36.1 µM -0.0411447488643791 0.484812949055745 no 1742 0.483590250176622 2557 60835 A selective serotonin reuptake inhibitor. SGTC_3026 9090633 49.47 µM -0.0431068511880631 0.484113793850141 no 1743 0.482808178959673 2485 25236842 SGTC_1 0258-0098 57.368 µM -0.0442415425305659 0.483709491849178 no 1744 0.482355934151817 2459 6790032 YDR047W HEM12 SGTC_74 000s-0487 160.283 µM -0.04577733598619 0.483162299863205 no 1745 0.48174386156611 2477 677548 SGTC_2420 aureobasidin a 50 nM -0.0459454477406734 0.483102404780612 no 1746 0.481676865172213 2602 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1829 berberine 14.4 µM -0.0461166244318541 0.483041418110071 no 1747 0.4816086478624 2601 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_661 1304-0007 33.6 µM -0.0461594983793957 0.483026143082446 no 1748 0.481591561827379 2512 3117130 SGTC_1962 st076595 64.5 µM -0.0478359908031412 0.482428866123471 no 1749 0.480923476432005 2501 279619 SGTC_1642 st009582 77.7 µM -0.0480293290033207 0.482359988840414 no 1750 0.480846434204307 2506 6739311 SGTC_1205 4161-2785 76 µM -0.0490747309159316 0.48198757061141 no 1751 0.480429870472524 2623 3498106 SGTC_2641 levomentholum 100 µM -0.0497872203920342 0.481733759449592 no 1752 0.480145975351817 2488 16666 SGTC_2520 obtusaquinone 4.71 µM -0.0500521310329914 0.4816393918295 no 1753 0.480040422895877 2524 5967872 SGTC_2468 5987765 72.9 µM -0.0504005814120761 0.48151526688816 no 1754 0.479901586538556 2557 26772094 SGTC_897 1000-0139 31.4 µM -0.0526345757367432 0.480719516854943 no 1755 0.479011533844179 2489 6151020 SGTC_1849 st056239 19.2 µM -0.0530877892809151 0.480558091206703 no 1756 0.478830980238094 2509 5393181 SGTC_743 1275-0778 158 µM -0.0549503485791029 0.479894718400388 no 1757 0.47808901003822 2554 2849257 YMR203W TOM40 SGTC_121 0557-0495 61.343 µM -0.0553835703851295 0.479740429178906 no 1758 0.477916442339947 2521 3104427 SGTC_2703 st077852 53.4 µM -0.0562301383991501 0.479438938087684 no 1759 0.477579236083452 2570 6281836 SGTC_2150 5556613 200 µM -0.056738752501958 0.479257809296007 no 1760 0.477376651845274 2534 743190 SGTC_1680 diphenhydramine 100 µM -0.0577454870512964 0.478899301402931 no 1761 0.47697568034742 2583 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_808 0711-0032 135 µM -0.0605652798829368 0.477895237746575 no 1762 0.475852712689922 2495 4252555 SGTC_643 k048-0106 28.4 µM -0.0609016924702925 0.477775458169946 no 1763 0.475718750776796 2597 6763920 SGTC_742 0kpi-0133 140 µM -0.0621313191643212 0.477337667203451 no 1764 0.475229128042131 2575 2728852 SGTC_1755 st041960 45.185 µM -0.0667540180391845 0.475692070505658 no 1765 0.473388764999538 2599 2257073 SGTC_1386 3228-0095 33.8 µM -0.0670584965971261 0.47558369592298 no 1766 0.473267567201348 2575 870181 SGTC_911 3456-4043 236 µM -0.0686529154448422 0.475016216092704 no 1767 0.47263294887776 2583 914281 SGTC_815 1582-0027 36.9 µM -0.0697411896534378 0.474628910476172 no 1768 0.472199828487347 2586 3128206 SGTC_2937 9044753 11.33 µM -0.0701199308553274 0.474494125976662 no 1769 0.47204910160899 2531 6465530 YGL099W LSG1 SGTC_1089 terbinafine 2.25 µM -0.0708886708357524 0.474220559680609 no 1770 0.471743180027486 2593 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2536 dehydroabietamide 32.04 µM -0.0710348220533051 0.47416855120681 no 1771 0.471685020744575 2580 3983547 SGTC_934 2950-0684 338 µM -0.0719639185495945 0.473837938971187 no 1772 0.471315311099105 2623 1121253 SGTC_1209 2323-2347 50.3 µM -0.0727874827879915 0.473544894679913 no 1773 0.470987615911317 2515 5412760 SGTC_1101 ebselen 5.29 µM -0.0759781938844793 0.472409698262129 no 1774 0.469718223400813 2536 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2076 5212012 200 µM -0.0765228010878315 0.472215959152385 no 1775 0.469501587256403 2518 604802 SGTC_3138 9097216 49.47 µM -0.0767438444368442 0.472137326843826 no 1776 0.469413662275307 2528 25237486 SGTC_3207 9114163 49.47 µM -0.0772013495937 0.471974580832776 no 1777 0.469231684016244 2594 849233 SGTC_939 1165-0479 45.3 µM -0.0773001669654653 0.471939429639105 no 1778 0.469192379043513 2555 1377347 SGTC_1605 st000082 49.1 µM -0.0778322862822329 0.471750148575948 no 1779 0.468980731800834 2674 1114022 SGTC_725 1497-0963 19 µM -0.0783802786528782 0.471555227951121 no 1780 0.468762780309034 2576 3549977 SGTC_2594 a-mangostin 100 µM -0.078533091936477 0.471500873551937 no 1781 0.468702003970304 2638 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2342 7990637 118.86 µM -0.0786051102785991 0.471475257417592 no 1782 0.468673361352176 2611 2033102 YER133W GLC7 SGTC_1344 1488-0097 29.1 µM -0.0794114873760811 0.471188446011327 no 1783 0.46835266594665 2621 747966 SGTC_1309 pyrazolanthrone 13.4 µM -0.0808120329877543 0.470690336938393 no 1784 0.467795719215077 2577 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0814374756511957 0.470467910774692 no 1785 0.46754702340627 2566 641818 YHR062C RPP1 SGTC_450 aminopyrene 156 nM -0.0814656897862931 0.470457877198976 no 1786 0.46753580487057 2542 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1775 st081588 35.1725 µM -0.0818152446831621 0.470333569238938 no 1787 0.467396816606179 2559 1426443 YGL099W LSG1 SGTC_586 0957-0265 8.15 µM -0.082400359945137 0.470125498284528 no 1788 0.467164174914992 2539 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1308 1187-1617 41.4 µM -0.0837277959663989 0.469653483366831 no 1789 0.466636428375079 2537 2882570 SGTC_3353 9151644 39.2805 µM -0.0845560312632132 0.469358997766018 no 1790 0.466307177895727 2632 4909158 SGTC_690 glyoxal 20.3 µM -0.0849920507951545 0.469203974302198 no 1791 0.466133855194788 2560 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2493 resveratrol 26.09 µM -0.0850099815014582 0.469197599274271 no 1792 0.466126727673279 2538 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1559 coumarin 343 70.1 µM -0.0853857896600141 0.46906398742224 no 1793 0.465977345055708 2633 108770 A hepatotoxic, DNA x-linker. SGTC_2678 equilin 100 µM -0.0854361842345785 0.469046070799481 no 1794 0.465957313727266 2565 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2670 beta-carotene 100 µM -0.0855697600281268 0.468998581325953 no 1795 0.465904219131649 2563 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_440 fluspirilene 35.1 µM -0.0857228186954776 0.468944165754834 no 1796 0.465843381099814 2806 3396 An atypical antipsychotic. SGTC_91 0417-1751 58.384 µM -0.0867992537894531 0.468561486913446 no 1797 0.465415540388232 2539 6795624 SGTC_2779 methotrexate 400 µM -0.0878193522240007 0.468198862876606 no 1798 0.465010128169845 2534 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1905 st060207 84.5 µM -0.0879090256042103 0.46816698708944 no 1799 0.464974491492537 2544 1948547 SGTC_1678 st019265 80.2 µM -0.0881681922981458 0.468074863435671 no 1800 0.464871498852854 2580 5367020 SGTC_2336 9001819 198.65 µM -0.0894639010643171 0.467614315232349 no 1801 0.464356620643235 2661 2989602 SGTC_2719 novobiocin 32.65 µM -0.0899374837300931 0.467445995253435 no 1802 0.464168447063684 2586 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2757 clomiphene 4.22 µM -0.0899396006824344 0.46744524286273 no 1803 0.464167605930716 2624 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3106 9121286 49.47 µM -0.0927521159409574 0.466445744377825 no 1804 0.463050246444937 2761 15943471 SGTC_25 0118-0223 35.662 µM -0.0953012340544854 0.46554003334255 no 1805 0.462037781241779 2595 5333628 SGTC_926 2268-1401 59.4 µM -0.0973487063969287 0.464812687912229 no 1806 0.461224738767987 2572 2931578 SGTC_1175 0741-0056 27.6 µM -0.0974414230277697 0.464779753958848 no 1807 0.461187925201617 2676 765927 SGTC_626 0214-0009 33 µM -0.0978732104843232 0.464626381550662 no 1808 0.461016486384441 2662 3437874 SGTC_3320 9137005 35.139 µM -0.0989349249401215 0.46424927927494 no 1809 0.460594969416952 2636 4908713 SGTC_1243 0416-0003 5.65 µM -0.0989385335465902 0.464247997616045 no 1810 0.460593536819915 2642 2141977 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0990184673504927 0.464219607840569 no 1811 0.460561803668015 2762 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1700 st030840 7.9285 µM -0.099637858253684 0.463999627389854 no 1812 0.460315918411558 2681 5499307 SGTC_2743 auranofin 4.32 µM -0.100106568264305 0.463833169486962 no 1813 0.46012986040446 2621 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1659 st012954 42.1 µM -0.101249813647411 0.463427183373127 no 1814 0.459676077142286 2688 24207262 SGTC_867 0518-0118 155 µM -0.101805809864985 0.463229753285128 no 1815 0.45945540700455 2607 6848158 SGTC_712 r015-0009 80.6 µM -0.101814996364675 0.463226491303888 no 1816 0.459451761066193 2662 6813872 YLR060W FRS1 SGTC_847 0342-0274 5.54 µM -0.102948698187116 0.462823950705644 no 1817 0.459001843716289 2694 18097 SGTC_2785 7756463 72.73 µM -0.103537231666772 0.46261499661659 no 1818 0.458768300833485 2596 2201551 SGTC_751 0833-0568 350 µM -0.104278612392616 0.462351790028911 no 1819 0.458474125103616 2644 6954252 SGTC_1663 st014140 55.4 µM -0.104523994853623 0.462264677442567 no 1820 0.458376763715426 2598 4207120 SGTC_762 1165-0429 115 µM -0.104656448580916 0.462217656142845 no 1821 0.458324210553505 2585 5967793 SGTC_758 0868-0029 16 µM -0.104717274858479 0.462196062887161 no 1822 0.458300076986589 2672 762687 SGTC_1167 k781-0610 148 µM -0.105458860820057 0.461932809737898 no 1823 0.458005856106731 2640 4525169 SGTC_2906 7926292 26.41 µM -0.10562459742478 0.461873977724286 no 1824 0.457940103997703 2695 2966319 SGTC_1907 st060210 83.7 µM -0.106493828677469 0.461565437821464 no 1825 0.457595275784333 2675 688793 SGTC_207 4185-0010 4.486 µM -0.107667561805581 0.461148849520085 no 1826 0.457129700911127 2594 3761753 SGTC_1770 st043884 66.3 µM -0.10893728672688 0.460698239259218 no 1827 0.456626116044444 2600 670149 SGTC_83 0170-0301 39.027 µM -0.111108898523848 0.459927677353252 no 1828 0.455764996217455 2593 3089716 SGTC_2726 cimetidine 79.27 µM -0.111893688325872 0.459649244041419 no 1829 0.455453850581296 2602 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2437 5741531 144.16 µM -0.111931558663688 0.459635808632824 no 1830 0.455438836816831 2711 2262990 SGTC_631 k072-0230 41.5 µM -0.112482600754852 0.459440318487121 no 1831 0.455220382386342 2704 5773147 SGTC_48 0382-0018 55 µM -0.113334376133718 0.45913815817251 no 1832 0.454882732295248 2763 762596 SGTC_3112 9123419 49.47 µM -0.113533616026564 0.459067482858127 no 1833 0.454803756815621 2597 17015854 SGTC_2585 alliin 100 µM -0.114017337426014 0.458895900309759 no 1834 0.454612024895377 2718 87310 A garlic compound which reacts with lipids. SGTC_2381 9035592 200 µM -0.114868906357811 0.45859385587247 no 1835 0.454274515525306 2644 4749657 SGTC_160 3453-0671 289.699 µM -0.115492637766953 0.458372638671676 no 1836 0.454027327820301 2637 5322268 SGTC_2449 5812982 45.77 µM -0.115527269147672 0.458360356426875 no 1837 0.454013603761352 2609 776185 SGTC_187 1488-2104 32.728 µM -0.115871873226748 0.458238142513004 no 1838 0.453877043713666 2681 2852859 SGTC_253 dyclonine 31.25 µM -0.116501448779982 0.458014873605113 no 1839 0.453627568978623 2596 3180 An oral anasthetic. SGTC_1378 2093-0007 380 nM -0.116675106378005 0.457953291041406 no 1840 0.45355875887526 2692 3618014 SGTC_736 0958-0254 92.6 µM -0.117097653793002 0.457803451237394 no 1841 0.453391334474292 2700 6812352 SGTC_3080 9117754 49.47 µM -0.121493621916536 0.456244953889695 no 1842 0.451650033128217 2738 9550191 SGTC_1850 st056238 17 µM -0.122851374902315 0.455763726239234 no 1843 0.451112395528118 2599 5393177 SGTC_1963 st076565 50.3 µM -0.1234511043975 0.455551185061017 no 1844 0.450874945533977 2627 4914280 SGTC_1382 3002-2117 298 µM -0.123556926660959 0.45551368349082 no 1845 0.450833049307094 2674 1497314 SGTC_1919 st067113 52.3 µM -0.124710614532875 0.455104862356624 no 1846 0.450376326914069 2747 1268243 SGTC_2477 5967686 25.23 µM -0.125585274775901 0.454794949187355 no 1847 0.450030109843939 2633 776118 SGTC_3076 9116187 49.47 µM -0.126496021070638 0.45447227910372 no 1848 0.449669649236826 2730 27241210 SGTC_2285 7945142 200 µM -0.126510096360928 0.454467292576814 no 1849 0.449664078759461 2717 2970608 SGTC_471 1-acyl-paf 4 µM -0.126672378719286 0.454409800473202 no 1850 0.44959985414334 2614 16759367 SGTC_2540 epiandrosterone 100 µM -0.127056823122106 0.454273606380497 no 1851 0.449447712290244 2650 441302 A steroid. SGTC_2362 9071156 126 µM -0.12742103809539 0.454144583767507 no 1852 0.449303582982386 2772 653133 SGTC_1306 1185-0270 9.02 µM -0.128835643707872 0.453643507847966 no 1853 0.44874385047678 2706 1548076 SGTC_1025 k007-0731 70 µM -0.129445012662196 0.453427682315335 no 1854 0.448502766153845 2632 6256118 SGTC_3171 9103192 49.47 µM -0.129551006700267 0.453390142882298 no 1855 0.448460833726622 2643 13018434 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.129972111279058 0.453241006279916 no 1856 0.448294245736847 2767 61125 An anti-inflammatory. SGTC_678 1218-2179 85.9 µM -0.131530010063307 0.452689324978837 no 1857 0.447678024095251 2636 6820081 YOR116C RPO31 SGTC_1037 k284-1091 78.7 µM -0.131664243437555 0.452641794670697 no 1858 0.447624934421139 2623 3334711 SGTC_1010 4112-3296 15.2 µM -0.131727502382479 0.452619395728639 no 1859 0.44759991565711 2747 704384 SGTC_3293 9120939 62.045 µM -0.132957910123812 0.452183758850201 no 1860 0.447113333870707 2765 934087 SGTC_1986 st071812 45 µM -0.133287417226246 0.452067103660059 no 1861 0.446983039204386 2651 11838594 SGTC_917 harmaline 728.087 nM -0.133333650599973 0.452050736018948 no 1862 0.446964757925402 2743 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_560 2332-1943 155 µM -0.134130486408151 0.451768651275423 no 1863 0.446649696395435 2635 21177716 SGTC_1503 4585-0012 61.3 µM -0.134871328317407 0.451506410553862 no 1864 0.446356804538478 2841 2922052 SGTC_3034 9090421 49.47 µM -0.134901625688717 0.451495686442117 no 1865 0.44634482709418 2619 17173761 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.134915408336985 0.451490807922995 no 1866 0.446339378423092 2660 688669 SGTC_291 SEC14.278 35.5 µM -0.135313350231354 0.4513499551988 no 1867 0.446182065098732 2692 1068044 SGTC_43 0570-0105 72.5 µM -0.13626374406346 0.451013585272931 no 1868 0.44580639227164 2655 1114046 YDL195W SEC31 SGTC_31 0508-1974 57.237 µM -0.136573939882198 0.450903806236144 no 1869 0.44568378820609 2673 6810525 SGTC_1896 st058441 89 µM -0.139863623730594 0.449739812047195 no 1870 0.444383871390883 2693 688759 SGTC_3202 9113761 49.47 µM -0.140449737447435 0.44953247156227 no 1871 0.444152331231763 2852 4798415 SGTC_2264 7948757 110.76 µM -0.142879532266498 0.448673067793498 no 1872 0.4431926617959 2642 2971411 SGTC_1074 carmofur 3.8 µM -0.143597475036795 0.44841918167019 no 1873 0.442909167310803 2649 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1832 st054113 55 µM -0.14448027017761 0.448107027765468 no 1874 0.442560617549652 2657 1251267 SGTC_2561 acetosyringone 100 µM -0.144840158328511 0.447979781525175 no 1875 0.442418537381329 2647 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1893 st059353 36.1 µM -0.146091364254296 0.447537432343218 no 1876 0.441924631801508 2712 3112488 SGTC_963 1269-2853 151 µM -0.147096031753029 0.447182291130967 no 1877 0.441528111005672 2701 3668223 SGTC_3099 9120367 49.47 µM -0.14771741954992 0.446962657132996 no 1878 0.441282891821875 2655 24824940 SGTC_599 1935-0052 86.5 µM -0.148239082203763 0.446778284262817 no 1879 0.441077044693856 2667 9557311 SGTC_3107 9121808 49.47 µM -0.14967460313827 0.446270983090194 no 1880 0.44051067309649 2656 662681 SGTC_1473 k844-0725 134 µM -0.151132301003136 0.445755934755003 no 1881 0.439935676313251 2692 54682906 SGTC_1691 st019933 84.6 µM -0.151499219816452 0.445626305728144 no 1882 0.439790963115364 2657 6176082 SGTC_3259 9138485 49.47 µM -0.151581516830971 0.44559723175081 no 1883 0.439758506182876 2885 17646153 SGTC_22 0964-0034 14.468 µM -0.154197336697814 0.444673265372509 no 1884 0.438727071042174 2713 138402 SGTC_2282 7944268 200 µM -0.156200385334379 0.443965946480926 no 1885 0.437937536505569 2825 2970414 SGTC_806 3966-4455 5.86 µM -0.157630319515033 0.443461115473786 no 1886 0.437374055365044 2694 714982 SGTC_1864 st057645 30.4 µM -0.157741668376522 0.443421808163126 no 1887 0.437330182448302 2704 688666 SGTC_2745 rifampicin 24.3 µM -0.158781257599277 0.443054849226899 no 1888 0.436920607867361 2776 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_458 nppb 133 µM -0.159350557531821 0.442853915820314 no 1889 0.436696345221842 2809 4549 A chloride channel blocker. SGTC_197 4544-0043 41.561 µM -0.15958902609334 0.442769753126817 no 1890 0.436602412045326 2698 896523 SGTC_3332 9141069 11.198 µM -0.160595777892014 0.442414468790657 no 1891 0.436205890244234 2685 17332883 SGTC_1379 2144-0755 36.5 µM -0.160827506544681 0.442332697920791 no 1892 0.436114630074515 2780 5392327 SGTC_2810 7959871 45.46 µM -0.162673521931837 0.441681376285462 no 1893 0.435387747848432 2795 2974535 SGTC_208 k072-0098 12.366 µM -0.163925432524751 0.441239759683695 no 1894 0.434894922828794 2698 5948901 SGTC_1603 st002045 67.8 µM -0.170107776643025 0.43905999389529 no 1895 0.432462688887913 2751 5887985 SGTC_272 doxorubicin 8.13 µM -0.170620432300703 0.438879324199841 no 1896 0.432261115428194 2676 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1929 genistein trimethyl ether 50.5 µM -0.170657792359919 0.43886615829511 no 1897 0.432246426341566 2736 136420 SGTC_336 4111-0029 111 µM -0.171205603107231 0.438673114338841 no 1898 0.432031050951125 2769 3131175 SGTC_408 cantharidin 100 µM -0.171502670787102 0.438568436254 no 1899 0.431914265285821 2763 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2905 7799065 20.05 µM -0.17172622633274 0.438489664558927 no 1900 0.431826383232279 2832 1296806 SGTC_2519 cryptotanshinone 88.04 µM -0.172133923170605 0.438346015391654 no 1901 0.431666121975485 2812 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2646 retinol 96.75 µM -0.172902827417481 0.43807511940634 no 1902 0.431363904585343 2791 445354 A vitamin A analog and teratogen. SGTC_2347 9049783 174.81 µM -0.173002828044726 0.438039889881825 no 1903 0.431324602342601 2853 6467988 YPL169C MEX67 SGTC_2387 9077560 195.08 µM -0.173225185806908 0.437961556551161 no 1904 0.431237213740693 2705 5303272 SGTC_1741 st038134 10.228 µM -0.174066536583641 0.437665183219134 no 1905 0.430906585811064 2898 1272587 SGTC_1966 st070145 16.1 µM -0.175912259683334 0.437015133482422 no 1906 0.430181436856653 2693 3748532 SGTC_1130 3454-2858 15.9 µM -0.176404448948409 0.436841816781367 no 1907 0.429988104859853 2835 715628 YIL048W NEO1 SGTC_2980 9014342 25.29 µM -0.177826073939272 0.43634128210884 no 1908 0.429429784827091 2898 2996599 SGTC_692 k241-0027 77.8 µM -0.177847122284217 0.436333872038819 no 1909 0.42942151949037 2874 3600480 SGTC_1581 himbacine 57.9 µM -0.179398242926107 0.43578786166944 no 1910 0.428812505474615 2723 5281825 An alkaloid muscarinic receptor antagonist. SGTC_155 k072-0202 43.6 µM -0.180114965137421 0.435535609374675 no 1911 0.428531157130224 2685 5857737 SGTC_26 0302-0163 425.158 µM -0.1816958428779 0.434979308102021 no 1912 0.427910714286472 2718 3100915 SGTC_2375 9072683 200 µM -0.182907318387544 0.434553084262737 no 1913 0.427435370264023 2735 16798029 SGTC_2278 7948257 134.34 µM -0.183994614619708 0.434170614182161 no 1914 0.427008839855029 2866 1247028 SGTC_2364 9055074 200 µM -0.184153810970822 0.434114620032491 no 1915 0.426946396603991 2819 6470630 SGTC_3093 9117344 49.47 µM -0.184487311336036 0.433997322199914 no 1916 0.426815590201291 2877 24824913 SGTC_1392 3455-1037 33.9 µM -0.184520650742132 0.433985596474919 no 1917 0.426802514172759 2871 981132 SGTC_345 1362-0200 395 µM -0.184982348663166 0.433823219749464 no 1918 0.426621440183794 2748 1419823 SGTC_1232 0279-0259 161 µM -0.185186647026183 0.433751372654294 no 1919 0.426541321040449 2748 1560000 SGTC_3340 9146634 11.102 µM -0.186448876900476 0.433307523697152 no 1920 0.426046383061497 2807 4907387 SGTC_2955 9076254 12.21 µM -0.186513976762352 0.43328463433792 no 1921 0.426020859647347 2807 16459619 SGTC_1843 st055809 45.5 µM -0.187897010120458 0.432798407544654 no 1922 0.425478693286605 2875 16413835 SGTC_425 3825-7017 13.1 µM -0.188998021276791 0.432411402714904 no 1923 0.425047183817643 2998 3397440 SGTC_481 bay k-8644 50 µM -0.189677206561018 0.432172701762096 no 1924 0.424781041538263 2755 2303 A calcium channel antagonist. SGTC_2833 9001315 45.46 µM -0.191953940978807 0.431372720222544 no 1925 0.423889142099467 2780 2989378 SGTC_3168 9103419 49.47 µM -0.192545219526644 0.431165007186716 no 1926 0.423657575220757 2733 16649256 SGTC_2047 4141938 200 µM -0.193018885764223 0.430998624465537 no 1927 0.423472088752603 2762 3807862 SGTC_684 1140-0066 328 µM -0.19431634914135 0.430542932828923 no 1928 0.422964092426649 2813 6813534 SGTC_2218 6965428 192.983 µM -0.194364391992332 0.430526061118354 no 1929 0.422945284644687 2737 675684 SGTC_2162 5663267 200 µM -0.194493130444533 0.430480851314639 no 1930 0.422894887070716 2835 6456493 SGTC_102 gallobenzophenone 83.616 µM -0.196013930260978 0.429946852640159 no 1931 0.422299631363042 2914 70837 SGTC_699 0375-0592 111 µM -0.196651773527802 0.429722924714975 no 1932 0.422050026094052 2800 762578 SGTC_2055 5235184 200 µM -0.197258081344563 0.429510088911423 no 1933 0.421812790518788 2911 2836034 SGTC_522 1273-0010 11.6 µM -0.198786224589046 0.428973746815352 no 1934 0.421214986065969 2989 5705015 SGTC_3289 9119912 71.43 µM -0.200329512406245 0.428432222404996 no 1935 0.420611441389979 2868 17014829 SGTC_517 1365-0151 113 µM -0.20065147489421 0.428319265908233 no 1936 0.420485552677121 2933 768657 SGTC_2082 5219693 150 µM -0.201211460206841 0.428122816086647 no 1937 0.420266615400019 2750 2834649 SGTC_2128 5255449 168.493 µM -0.20127852061122 0.428099291655001 no 1938 0.420240398467938 2767 736008 SGTC_1277 0873-0036 22 µM -0.201682311966801 0.427957649208919 no 1939 0.420082545726979 2835 5965735 SGTC_1263 0774-1208 64.8 µM -0.202504471770854 0.427669279656006 no 1940 0.419761181431911 2884 906585 SGTC_567 1080-0542 68.4 µM -0.20283627087185 0.427552913264588 no 1941 0.419631503556889 2762 5950415 SGTC_3098 9119039 49.47 µM -0.202859533688585 0.427544754919292 no 1942 0.419622412019091 2750 17161528 SGTC_1093 fluphenazine 7.97 µM -0.203214782938767 0.427420171705924 no 1943 0.419483579393628 2773 6602611 An atypical antipsychotic. SGTC_2049 5262831 67.185 µM -0.203987980921274 0.427149042081419 no 1944 0.419181445637741 2833 763417 SGTC_827 3253-0474 693 µM -0.204613647144118 0.426929671128892 no 1945 0.418936996055899 2867 5402065 SGTC_1995 st072814 61.1 µM -0.204887207725815 0.426833762474418 no 1946 0.418830124981302 2790 5769371 SGTC_3209 9113616 49.47 µM -0.204911019863511 0.426825414290215 no 1947 0.418820822649676 2937 16649353 SGTC_1487 3970-0795 2.82 µM -0.205653354849482 0.426565179051568 no 1948 0.418530848534367 2846 3765103 SGTC_1871 st057448 67.3 µM -0.207566097950574 0.425894789500698 no 1949 0.417783888859691 2947 691747 SGTC_1931 st074438 57.1 µM -0.208701168791485 0.425497064247551 no 1950 0.417340763834722 2715 2787313 SGTC_1424 4048-1941 275 µM -0.208959663854413 0.425406498972424 no 1951 0.417239863525944 2890 X1424 SGTC_1638 st008370 60.6 µM -0.209125535440677 0.425348386953222 no 1952 0.417175120500882 2735 24207134 SGTC_3042 9091578 49.47 µM -0.211549132670109 0.424499481207261 no 1953 0.416229398640095 2767 25236497 SGTC_303 1348-1668 34.2 µM -0.212720734911948 0.424089233073408 no 1954 0.415772396384954 2811 5380509 SGTC_1418 3966-3099 2.4 µM -0.214268436917994 0.423547416032448 no 1955 0.415168865065535 2864 740335 SGTC_290 2043-6722 48.1 µM -0.214390038224247 0.423504852152153 no 1956 0.415121454710435 2866 773758 YLR208W SEC13 SGTC_1779 st039427 55 µM -0.214467564598781 0.423477716204592 no 1957 0.415091229093547 2902 1124498 SGTC_3025 9087895 49.47 µM -0.21458797216639 0.423435571609663 no 1958 0.415044286156002 2908 17173641 SGTC_3348 9149464 3.537 µM -0.215072991396664 0.423265815914672 no 1959 0.414855205451911 2752 1951442 SGTC_2085 5307070 144.047 µM -0.216796976137008 0.422662540440947 no 1960 0.414183284306835 2765 2840351 SGTC_2138 5575593 77.673 µM -0.218675447824104 0.42200541170082 no 1961 0.413451437954642 2797 762213 SGTC_1117 retinoic acid 1.10837 µM -0.218933645082836 0.421915105820744 no 1962 0.413350868597439 2954 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1414 3917-0015 5.4 µM -0.219516717583044 0.421711188189317 no 1963 0.413123779339041 2826 6618702 SGTC_2771 fluoxetine 41.05 µM -0.220099055389964 0.421507548453073 no 1964 0.412897005230951 2975 3386 A selective serotonin reuptake inhibitor. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.221551850422549 0.42099960711921 no 1965 0.412331384350381 2974 6728940 SGTC_337 1315-0038 354 µM -0.221919533636159 0.420871074698136 no 1966 0.412188262003403 2809 1626437 SGTC_844 0330-0132 15.3 µM -0.222331150436034 0.420727194252798 no 1967 0.412028052165089 2926 2828079 SGTC_2043 5101342 149 µM -0.223348199767072 0.420371730615671 no 1968 0.411632258286656 2826 678451 SGTC_2584 androsterone 48.74 µM -0.223972099301254 0.420153706839054 no 1969 0.411389506644333 2928 2754130 A steroid. SGTC_3205 9113483 49.47 µM -0.226287660828941 0.419344740834289 no 1970 0.410488847371145 2998 17018033 SGTC_3330 9141424 71.43 µM -0.227225665750782 0.419017135652856 no 1971 0.410124135613687 2938 27261020 SGTC_2413 inermin 26.06 µM -0.227470582568382 0.418931605870654 no 1972 0.410028920706986 3115 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2677 mitomycin C 100 µM -0.228027570779121 0.418737108875188 no 1973 0.409812403351607 2827 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1855 st056195 39.6 µM -0.229012639720172 0.418393177270926 no 1974 0.40942954605009 3000 4028379 SGTC_1463 k081-0032 34.1 µM -0.22929477113254 0.418294684062843 no 1975 0.409319908632568 2882 977755 SGTC_2828 7998861 71.43 µM -0.229701610626213 0.41815266378503 no 1976 0.409161821635844 2915 2988188 SGTC_2098 5376439 882.5 nM -0.232888697529635 0.417040480275795 no 1977 0.407923917613082 2908 2844116 SGTC_318 1488-0629 67.2 µM -0.233133159382665 0.416955198801029 no 1978 0.407829003378073 2898 3662576 SGTC_1292 0kpi-0043 232 µM -0.235714586751616 0.416054896998705 no 1979 0.406827075103342 2875 3333905 SGTC_2118 5526350 200 µM -0.236001880449076 0.415954727236972 no 1980 0.406715605499888 2943 743594 SGTC_592 k241-0073 46.5 µM -0.237653581737058 0.415378940025479 no 1981 0.406074894311204 2941 4230158 SGTC_1708 st033234 31.827 µM -0.237841706219503 0.415313370860294 no 1982 0.406001934892481 2950 674664 SGTC_1150 3909-7983 10.9 µM -0.238318176642893 0.415147311760182 no 1983 0.405817162255632 2847 23965914 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.238365071638068 0.415130968771908 no 1984 0.40579897776516 2953 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1084 voriconazole 435 nM -0.238645265171672 0.415033323893741 no 1985 0.405690331246774 2901 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1461 k072-0203 53.8 µM -0.239358225209068 0.414784887537555 no 1986 0.405413910016189 2788 5418714 SGTC_696 1560-0013 611 µM -0.241479313731811 0.414045979959521 no 1987 0.404591823707596 3044 1650269 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.242147393662447 0.413813308869749 no 1988 0.404332977932008 2821 4620898 SGTC_3157 9099274 49.47 µM -0.242542837102552 0.413675602686557 no 1989 0.404179784152678 2930 17217662 SGTC_824 1304-0008 100 µM -0.243197978430348 0.413447484677847 no 1990 0.403926016419472 2847 768245 SGTC_1509 1326-1131 80 µM -0.243632391857102 0.413296239484755 no 1991 0.403757769499837 2874 768313 SGTC_1109 tnp00067 928.257 nM -0.244524438151356 0.412985705386093 no 1992 0.403412338701154 2868 676295 SGTC_2450 5739737 12.93 µM -0.245381051082558 0.412687557383536 no 1993 0.403080699818019 2933 2262825 SGTC_257 daunorubicin 18.5 µM -0.24807308090149 0.41175091285786 no 1994 0.402038931526873 2948 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1020 4335-0961 93.3 µM -0.248094346831396 0.411743515744759 no 1995 0.40203070474463 2810 669075 SGTC_504 lovastatin 124 µM -0.248402711314088 0.411636258174586 no 1996 0.401911417993761 2866 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3306 9127676 59.7925 µM -0.248748315450541 0.41151605548516 no 1997 0.401777736430942 2932 41905287 SGTC_1144 3486-0183 12.5 µM -0.249366669348772 0.411301009917522 no 1998 0.401538582458896 2855 6744069 SGTC_1460 k062-0059 9.15 µM -0.250047295355936 0.411064338724593 no 1999 0.401275386818984 2749 1373085 SGTC_958 1222-0007 33 µM -0.250923336866859 0.410759764180582 no 2000 0.400936690643929 3023 7312461 SGTC_798 1287-0182 476 µM -0.251005889895061 0.410731065627904 no 2001 0.400904777731671 3020 1649755 SGTC_252 miconazole 1.30953 nM -0.25349462846675 0.409866111082411 no 2002 0.399943005755182 2955 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_733 4069-0007 56.1 µM -0.255811102447597 0.409061420479542 no 2003 0.399048350289637 2875 5717425 YNL287W SEC21 SGTC_2179 6298986 200 µM -0.255881283132629 0.409037047260961 no 2004 0.399021253751909 3004 738374 SGTC_2432 5630864 12.22 µM -0.256039263890952 0.408982183031211 no 2005 0.398960259667787 3008 5714970 SGTC_2608 thymoquinone 42.66 µM -0.256246891324942 0.408910080004718 no 2006 0.398880101472926 2872 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1500 4488-1866 171 µM -0.257450916523467 0.408492017577725 no 2007 0.39841535070204 2999 2900003 SGTC_2605 digitonin 300 nM -0.257671669411933 0.408415378894303 no 2008 0.39833015623599 2961 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1293 1000-1278 195 µM -0.25770277823814 0.408404579138274 no 2009 0.398318150894272 2999 678847 SGTC_1879 gemcitabine 100 µM -0.258326530060649 0.408188051828209 no 2010 0.398077456455602 2872 60750 A nucleoside analog which inhibits DNA replication. SGTC_774 k060-0086 136 µM -0.262338770382708 0.4067959277561 no 2011 0.396530136975405 2952 5911235 SGTC_865 0488-0499 301 µM -0.262874631173576 0.406610089239139 no 2012 0.396323605107433 2957 9634651 SGTC_765 1319-0117 244 µM -0.264657699703096 0.405991866076608 no 2013 0.395636583254728 2858 3487746 YGL099W LSG1 SGTC_1245 0418-0076 17.2 µM -0.264705960463835 0.405975136419899 no 2014 0.395617992729502 3054 6790114 SGTC_395 anisomycin 6.25 µM -0.268051317803439 0.404815883948885 no 2015 0.39432990883668 2933 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_964 1287-0107 19.4 µM -0.268541327082277 0.404646152973709 no 2016 0.394141334115624 3038 51516812 YPR165W RHO1 SGTC_837 0091-0265 12.5 µM -0.268750805357566 0.404573598693746 no 2017 0.394060726256964 2888 759367 SGTC_3064 1327-0027 10 µM -0.268768134130641 0.404567596897726 no 2018 0.394054058297112 2861 16000455 YPR107C YTH1 SGTC_1617 st002906 78 µM -0.269408932602835 0.404345673033601 no 2019 0.393807506489796 2857 5150859 SGTC_1394 3474-0001 65.7 µM -0.269865777380291 0.404187475528174 no 2020 0.393631758167467 2923 5017666 YIL048W NEO1 SGTC_734 2023-0417 80 µM -0.270146217004012 0.404090371858487 no 2021 0.393523883690477 2994 3935732 SGTC_2003 4023581 200 µM -0.273834015330257 0.402814004565532 no 2022 0.392106090954704 3032 16641307 SGTC_2190 6049624 200 µM -0.274513699649378 0.402578874642199 no 2023 0.391844938527084 2946 2265554 SGTC_2394 5221648 200 µM -0.274888073751845 0.402449378747621 no 2024 0.391701115042773 3019 788586 SGTC_2421 5690543 90.72 µM -0.275109738964791 0.40237270985826 no 2025 0.391615964782863 2990 3397993 SGTC_492 tmb-8 126 µM -0.275547161723477 0.4022214264252 no 2026 0.391447948865642 2957 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1932 st074806 40.9 µM -0.276024215078827 0.402056453376718 no 2027 0.391264733755866 3132 17251235 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.278018734485582 0.401366904412116 no 2028 0.390498988717346 2956 75037 A free radical scavenger. SGTC_2095 5432005 200 µM -0.278688503272664 0.401135419460826 no 2029 0.390241943081659 2896 783734 SGTC_2644 guaiazulene 100 µM -0.278823855617523 0.401088643304255 no 2030 0.390190003024712 2988 3515 A coloring agent. SGTC_987 1497-1013 404 µM -0.280208421681043 0.400610235324944 no 2031 0.389658802909385 2891 1676435 SGTC_1402 3909-7673 35.9 µM -0.286143471589536 0.398561199668024 no 2032 0.387384118672902 2855 5328014 SGTC_2920 7982904 15.77 µM -0.288773425816826 0.397654115544415 no 2033 0.386377384636038 3029 6456808 SGTC_627 1391-0720 175 µM -0.289274626629732 0.397481311519106 no 2034 0.386185613845754 2999 997839 SGTC_1916 st067606 49.2 µM -0.289538111393438 0.397390475303289 no 2035 0.386084809750282 2998 19590279 SGTC_2995 9067767 71.4286 µM -0.289883012608608 0.39727157922418 no 2036 0.385952868941912 2988 11673567 SGTC_1786 berberine 21.6 µM -0.29008353765216 0.397202457611403 no 2037 0.385876164819069 2911 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2890 9046729 58.44 µM -0.290151993950879 0.397178861249195 no 2038 0.385849980181816 2937 903329 SGTC_1702 st027038 51 µM -0.290318837915194 0.39712135298829 no 2039 0.385786164293174 2971 5521182 SGTC_2812 7970281 58.44 µM -0.29090599356007 0.396918988274417 no 2040 0.385561608633587 3063 2233435 SGTC_2899 9053889 58.44 µM -0.292841705252612 0.396252037077347 no 2041 0.384821574368281 3030 6470052 SGTC_1651 st011928 86.1 µM -0.294239414825894 0.395770643579378 no 2042 0.384287482149181 3035 720198 SGTC_3131 9127911 49.47 µM -0.295245412461142 0.395424260253881 no 2043 0.383903206595445 3167 45595681 SGTC_1296 1068-0102 11.9 µM -0.295727071059801 0.395258445641706 no 2044 0.383719260830213 3019 767053 SGTC_3282 9108498 15.4605 µM -0.296992497732867 0.394822903374537 no 2045 0.383236118407956 3022 16459645 SGTC_1795 st049545 62.3 µM -0.297932956727795 0.394499295555028 no 2046 0.3828771668495 3052 5291882 SGTC_753 1322-0200 289 µM -0.29856889117568 0.39428051453765 no 2047 0.382634502276124 3071 5403907 SGTC_1937 st074714 47.2 µM -0.298708199496983 0.394232592639345 no 2048 0.382581350124226 2886 17250970 SGTC_3044 9093193 49.47 µM -0.300040736897294 0.393774282346154 no 2049 0.38207304134972 3038 25236277 SGTC_2780 5215298 71.43 µM -0.301114115399185 0.393405213590165 no 2050 0.381663738862575 3086 2834131 SGTC_1411 3909-8223 150 µM -0.30265880966471 0.392874256510541 no 2051 0.381074945707777 3054 X1411 SGTC_1701 st028638 40.4 µM -0.306532960588035 0.391543474919719 no 2052 0.379599443967193 3067 3490878 SGTC_2710 st078562 53.7235 µM -0.307391268127657 0.391248814973265 no 2053 0.379272786852374 2904 17250908 SGTC_2071 5230951 39.92 µM -0.307614776570205 0.391172093986333 no 2054 0.379187737509018 3018 1799272 SGTC_233 rapamycin 362 pM -0.308141825480392 0.390991197176472 no 2055 0.378987208226182 2967 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2211 7117706 200 µM -0.308774514002248 0.390774073270941 no 2056 0.378746528655899 3042 822771 SGTC_1429 4049-0205 9.46 µM -0.309465552476401 0.390536963931146 no 2057 0.378483706036812 2970 22774478 SGTC_1948 st076329 66.6 µM -0.309803003497298 0.390421192415388 no 2058 0.378355383726794 2889 24208413 SGTC_1229 0139-0193 12.2 µM -0.310777786778332 0.390086821777997 no 2059 0.377984778826342 3110 3090752 SGTC_2243 6634756 200 µM -0.310949460880845 0.390027942456959 no 2060 0.377919521305857 3206 885676 SGTC_1425 4048-4433 7.33 µM -0.313304092985538 0.389220625961883 no 2061 0.377024820406925 3030 23734946 SGTC_2070 5230947 200 µM -0.313562577033611 0.389132030368959 no 2062 0.376926643088148 3052 2835538 SGTC_2839 9003951 25.97 µM -0.31546921726471 0.388478706405907 no 2063 0.376202709878451 3073 2990634 SGTC_1295 1013-0063 9.78 µM -0.315655811389952 0.388414785502083 no 2064 0.376131885206065 3074 6826038 SGTC_2018 5133068 143 µM -0.316731860955907 0.388046225938095 no 2065 0.375723535488959 2909 785362 SGTC_2366 9070441 60.58 µM -0.316935625443739 0.387976445560171 no 2066 0.375646224623313 2965 6837235 SGTC_410 α-linolenic acid 100 µM -0.317337276074125 0.38783890847287 no 2067 0.37549384783429 3083 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1341 1486-1360 280 µM -0.317627704080146 0.387739466074874 no 2068 0.375383678386427 2946 3976547 SGTC_146 3448-8650 53.125 µM -0.317736606354894 0.387702179890411 no 2069 0.375342370583764 2986 2891488 YIL048W NEO1 SGTC_1127 asiatic acid 681.4 nM -0.318018799236844 0.387605566931125 no 2070 0.375235338443835 2948 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_79 0052-0007 94.094 µM -0.319739469054616 0.387016620638239 no 2071 0.37458291857334 3124 2801472 SGTC_3235 9132602 49.47 µM -0.320856159340699 0.386634541900721 no 2072 0.374159699240116 3088 4912240 SGTC_521 r062-0005 13.8 µM -0.321286781228261 0.386487232736426 no 2073 0.373996536447622 2946 2832033 SGTC_2808 7946468 45.46 µM -0.321437917263579 0.386435535286128 no 2074 0.37393927629795 3051 2970879 SGTC_2959 9079155 11 µM -0.322412948178899 0.38610206561362 no 2075 0.373569938148829 3126 16189457 SGTC_1721 st082152 9.2685 µM -0.323384950928153 0.385769715336271 no 2076 0.373201862605227 2914 5296051 SGTC_797 k781-0471 270 µM -0.325878352378101 0.384917547469676 no 2077 0.372258197367832 2976 23738129 SGTC_3322 9139058 2.11 µM -0.327199611407972 0.384466206740673 no 2078 0.371758457389426 3160 4908926 YPR165W RHO1 SGTC_2638 epoxomicin 18 µM -0.328373251505042 0.384065423774441 no 2079 0.371314732463 3086 9915668 A protesome inhibitor. SGTC_2958 9077254 16.72 µM -0.330573964321011 0.383314243116672 no 2080 0.370483157497201 3185 16457351 SGTC_2340 7987427 183.45 µM -0.330700384250945 0.383271104840709 no 2081 0.37043540601351 3122 2239331 SGTC_2963 9082507 9 µM -0.331389217076494 0.383036079838129 no 2082 0.370175254364271 3151 16459611 SGTC_335 4077-0256 27.6 µM -0.332787999043981 0.382558957646229 no 2083 0.36964715889195 3064 3121989 SGTC_1097 itavastatin 7.23 µM -0.33301563794997 0.382481327237597 no 2084 0.369561239437405 3029 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3045 9092950 49.47 µM -0.333429137569684 0.382340325883041 no 2085 0.369405185847171 3134 44120432 SGTC_2348 9022543 33.42 µM -0.333662315935389 0.382260820074635 no 2086 0.369317194474872 3118 3162678 YDL140C RPO21 SGTC_605 1315-0399 119 µM -0.33390857093281 0.382176860973452 no 2087 0.369224275983001 3140 24020461 SGTC_663 1486-0733 13.9 µM -0.334354912959846 0.382024697573821 no 2088 0.369055878865646 2993 722445 YPR165W RHO1 SGTC_3345 9148410 3.559 µM -0.334704869251306 0.381905405981169 no 2089 0.368923863990943 3131 4903596 SGTC_3252 9135871 49.47 µM -0.337118184753667 0.381083071220339 no 2090 0.368013904773345 3146 17682838 SGTC_1433 4060-0023 7.6 µM -0.339040803343172 0.380428324846091 no 2091 0.367289495995919 3115 3840627 SGTC_2395 5646831 180.19 µM -0.339864919862997 0.380147777289551 no 2092 0.366979127823234 3180 6808628 SGTC_1138 3761-0006 1.03 µM -0.340626546642238 0.379888558680102 no 2093 0.366692371011524 3050 12061087 SGTC_193 1273-0060 1.558 µM -0.342051117609566 0.379403852869602 no 2094 0.366156211740297 3034 2847393 YHR072W ERG7 SGTC_544 k015-0020 52.4 µM -0.342237732497559 0.379340371759212 no 2095 0.366085995675189 3058 3008304 SGTC_350 k064-0020 19.8 µM -0.342555940253625 0.379232133978046 no 2096 0.365966276576231 3191 2790705 SGTC_229 benomyl 22.8748 µM -0.343350095156522 0.378962044963977 no 2097 0.365667549134525 3092 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2045 5106652 78.05 µM -0.345613010029766 0.378192760825861 no 2098 0.364816783630756 3119 673349 SGTC_468 gf-109203x 121 µM -0.345956156699082 0.378076149239061 no 2099 0.364687832185965 3067 2396 A protein kinase C inhibitor. SGTC_1957 st077035 62.4 µM -0.347279131556198 0.377626666530091 no 2100 0.364190813478329 3131 705593 SGTC_3304 9125678 46.087 µM -0.347658681943475 0.377497744267883 no 2101 0.364048265091074 3012 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_80 0159-0065 512.242 µM -0.347817187269636 0.377443908643415 no 2102 0.363988740541425 3067 1548079 SGTC_1407 3909-7909 12.3 µM -0.348896271290334 0.377077465924919 no 2103 0.36358359229122 3024 4411780 SGTC_114 0364-0001 490.298 µM -0.349061811618565 0.377021260393816 no 2104 0.363521452712752 3075 4003655 SGTC_1376 2910-0861 41.3 µM -0.349605887459143 0.376836549922788 no 2105 0.363317245947293 3006 1112859 SGTC_189 3970-0742 2.116 µM -0.350936220874201 0.376385028538936 no 2106 0.362818098581581 3067 2891807 SGTC_2865 9030313 51.95 µM -0.351731631039218 0.376115143346171 no 2107 0.362519768183009 2988 42562754 SGTC_2193 5925765 200 µM -0.351953016602025 0.376040037292532 no 2108 0.362436749077837 3117 877370 SGTC_1630 st005209 31.3 µM -0.352149593487792 0.375973351629948 no 2109 0.362363038594266 3117 3367314 SGTC_3014 9081533 49.47 µM -0.352914227499034 0.375713996626467 no 2110 0.362076372135835 3158 21367265 SGTC_2288 7946289 167.31 µM -0.353770616751646 0.375423585966026 no 2111 0.361755397849978 3225 1246052 SGTC_1938 st074717 56.4 µM -0.355537073526303 0.374824784882964 no 2112 0.361093638033435 2965 17250979 SGTC_2108 5365811 200 µM -0.355831492373348 0.374725010811349 no 2113 0.360983381561786 3145 780283 SGTC_783 0848-0141 92.7 µM -0.358735580054066 0.373741309906946 no 2114 0.359896454302397 3003 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_392 N-ethylmaleimide 8.33 µM -0.359152947184036 0.37360000264275 no 2115 0.359740337070687 3062 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1737 st035557 69.7 µM -0.359275156462684 0.373558629674839 no 2116 0.359694628808535 3045 5716916 SGTC_419 nsc-638432 893 µM -0.360055756262724 0.373294398293871 no 2117 0.359402719133301 3108 368090 SGTC_1805 st050013 60.3 µM -0.361368171710619 0.372850282771534 no 2118 0.35891211899407 3072 4037144 SGTC_587 k089-0003 57 µM -0.362430291200092 0.372490989937825 no 2119 0.358515253424288 3088 9659696 SGTC_2052 5265182 7.135 µM -0.36270630423246 0.37239763864357 no 2120 0.35841214494179 3183 1239884 SGTC_1499 4480-0877 67.3 µM -0.362795528552718 0.372367463389827 no 2121 0.358378816171259 3041 2861909 SGTC_2126 5251174 33.877 µM -0.362849285621928 0.372349283375114 no 2122 0.358358736325857 3224 790722 SGTC_1554 st069299 38.7 µM -0.36303212314975 0.372287451982016 no 2123 0.358290444066954 3116 24207999 SGTC_2568 diosmetin 100 µM -0.363741196866079 0.372047690922377 no 2124 0.358025638456949 3205 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1794 st048918 76.9 µM -0.364578336529732 0.371764690423976 no 2125 0.357713094165307 3118 672303 SGTC_1856 st057054 55.7 µM -0.366312978504246 0.371178504105171 no 2126 0.35706577309881 3262 1266018 SGTC_176 1486-1328 72.834 µM -0.367391469798275 0.370814200829527 no 2127 0.356663516761191 3105 22310231 SGTC_1276 0871-0068 94.2 µM -0.367423919933316 0.370803241299965 no 2128 0.356651415957582 3123 3414906 SGTC_2923 7992654 58.14 µM -0.368062165621916 0.370587705038128 no 2129 0.356413440563903 3075 2985126 SGTC_2063 5246145 200 µM -0.368990166224563 0.370274390695463 no 2130 0.356067527303728 3168 711240 SGTC_326 k292-0812 17.5 µM -0.370940500206504 0.369616193776991 no 2131 0.355340924436558 3143 3579357 SGTC_414 piperonyl butoxide 100 µM -0.373883729130065 0.368623639070822 no 2132 0.354245411141167 3064 5794 A potent inhibitor of cytochrome P450. SGTC_1364 1653-0028 37.6 µM -0.37397221126018 0.368593813481153 no 2133 0.354212495399447 3108 5718652 SGTC_708 3448-5400 146 µM -0.374104041252625 0.368549377646119 no 2134 0.354163456082517 3163 3462195 SGTC_905 2-aminofluorene 215 µM -0.374235523269724 0.368505060853673 no 2135 0.354114548617515 3059 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2588 indole-3-carbinol 100 µM -0.376134833027053 0.367865082642092 no 2136 0.353408329755555 3185 3712 Induces cell cycle arrest. SGTC_1947 st076332 61.6 µM -0.37689279401066 0.367609787630478 no 2137 0.353126638387559 3188 24208416 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.378785289943698 0.366972616220458 no 2138 0.352423655883214 3185 6708760 SGTC_794 k038-0031 316 µM -0.379102089321926 0.366865990963174 no 2139 0.352306027424679 3163 6624242 SGTC_223 busulfan 5 mM -0.380452284538575 0.366411670629436 no 2140 0.351804854845174 3157 2478 A DNA alkylator. SGTC_2325 6158266 200 µM -0.381235597935135 0.366148183221856 no 2141 0.351514218370563 3140 3623240 SGTC_1421 4029-0249 71.4 µM -0.382017163799884 0.365885346530532 no 2142 0.351224316779571 3230 2894095 SGTC_3224 9130643 49.47 µM -0.383753063866879 0.365301797298718 no 2143 0.350580739454617 3265 17644395 SGTC_2776 terbinafine 19.92 µM -0.385399312424602 0.364748673726595 no 2144 0.349970795957446 3145 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2068 5226020 147 µM -0.389033392485488 0.363528655685634 no 2145 0.348625722336902 3122 1810509 SGTC_1636 st007707 68.9 µM -0.390354541839306 0.363085467057022 no 2146 0.348137198595753 3290 403051 SGTC_3100 9120536 49.47 µM -0.390647687178456 0.362987154262422 no 2147 0.348028835842245 3153 16421196 SGTC_110 0850-0284 111.64 µM -0.390737991140757 0.36295687064348 no 2148 0.347995456995847 2992 3906265 SGTC_2354 9060492 162 µM -0.391354327441659 0.362750203893539 no 2149 0.347767673485553 3240 6471895 SGTC_548 1436-0017 110 µM -0.391386885745901 0.362739287719849 no 2150 0.347755642223303 3235 9677137 SGTC_1863 st057641 20.1 µM -0.391588098221126 0.362671827519254 no 2151 0.347681291628153 3164 3921635 SGTC_1366 1683-0113 21.9 µM -0.392257941813915 0.362447280802193 no 2152 0.347433818039031 3095 708623 SGTC_3000 9075062 71.4286 µM -0.392380744180194 0.362406119802191 no 2153 0.347388455777402 3096 17057871 SGTC_373 0844-0104 25.9 µM -0.3926265240669 0.362323743871565 no 2154 0.347297673119131 3230 5375804 SGTC_1510 1123-0200 71.5 µM -0.395583891358698 0.361333049340764 no 2155 0.346206011293668 3308 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_764 1951-2361 146 µM -0.396249525673957 0.36111019500129 no 2156 0.345960479394392 3114 5438930 SGTC_702 1488-0190 94 µM -0.396374643395939 0.361068310853634 no 2157 0.345914334565622 3185 949357 SGTC_2576 guaiol 23.12 µM -0.399601880389144 0.359988544622868 no 2158 0.344724885625476 3168 227829 SGTC_1891 st059073 26.2 µM -0.400038396690188 0.359842580881616 no 2159 0.344564118143784 3257 688754 SGTC_3242 9133940 49.47 µM -0.40157585116402 0.359328644740896 no 2160 0.343998102567615 3237 17248444 SGTC_61 0978-8327 98.565 µM -0.402825976244633 0.358910943769594 no 2161 0.343538125095556 3222 6150059 YHR072W ERG7 SGTC_525 k781-2675 26.7 µM -0.403317661158727 0.358746704577581 no 2162 0.343357275430621 3218 3651118 YDL195W SEC31 SGTC_198 3454-2873 16.191 µM -0.404049953130015 0.358502143006485 no 2163 0.343087993084673 3131 710957 SGTC_2521 angolensin 13.4 µM -0.405069524676061 0.358161736094335 no 2164 0.342713203446186 3252 821428 A flavenoid. SGTC_2011 4012611 177 µM -0.406665630559292 0.357629066643984 no 2165 0.342126793418095 3089 2049887 SGTC_3212 9128307 49.47 µM -0.407261204663432 0.357430376268317 no 2166 0.341908076635201 3014 27243542 SGTC_901 1112-0062 60.1 µM -0.407946658319648 0.357201748869238 no 2167 0.341656418424816 3126 1908457 SGTC_524 r073-0010 27.8 µM -0.408783467504141 0.35692270757573 no 2168 0.341349286769861 3069 2772106 SGTC_1705 st027868 56.3335 µM -0.410376431190288 0.356391731601961 no 2169 0.340764916371758 3186 292948 SGTC_1253 0550-0034 176 µM -0.411108648090974 0.356147758068619 no 2170 0.340496434468096 3229 5969915 SGTC_182 3448-4371 550.524 µM -0.412517462454256 0.355678509017076 no 2171 0.339980092045843 3216 3491403 SGTC_855 0428-0020 25 µM -0.413670422755349 0.355294642681265 no 2172 0.339557745486848 3149 6812414 SGTC_608 k048-0125 159 µM -0.415780550415778 0.354592477629875 no 2173 0.338785296148048 3257 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2746 daunorubicin 9.88 µM -0.416845105925555 0.354238423909803 no 2174 0.338395853787325 3159 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3338 9144300 39.5675 µM -0.417800984588616 0.353920621637892 no 2175 0.338046315481724 3173 4901274 SGTC_2461 5755302 26.15 µM -0.418307033172228 0.353752416158407 no 2176 0.337861324040465 3262 2788904 SGTC_1428 4049-0204 61.7 µM -0.418427824535923 0.35371227053818 no 2177 0.337817173260026 3250 X1428 SGTC_93 0109-0045 59.227 µM -0.418783218429701 0.353594163017375 no 2178 0.337687285212643 3228 88733 SGTC_1676 st018489 23.4 µM -0.421906549938538 0.35255679823381 no 2179 0.336546614487537 3140 3696235 SGTC_2545 solidagenone 89.61 µM -0.422073814860242 0.352501274696172 no 2180 0.336485570023224 3039 6708572 An anti ulcer agent SGTC_3048 9093155 49.47 µM -0.42252618519822 0.352351126252083 no 2181 0.336320496001312 3254 25236002 SGTC_705 1124-0212 310 µM -0.422595755265252 0.352328036952715 no 2182 0.336295112053882 3297 9554485 SGTC_3271 9137798 49.47 µM -0.424200830750084 0.351795486885673 no 2183 0.335709677506839 3235 6498326 SGTC_529 4076-0302 30.3 µM -0.424628159756585 0.351653751792308 no 2184 0.335553880822415 3155 5816522 SGTC_2312 7706453 155.7 µM -0.425079057165385 0.351504221963326 no 2185 0.335389522160265 3148 976098 SGTC_2691 st077356 60.2 µM -0.42706409696157 0.350846202348114 no 2186 0.334666321241565 3302 2839272 SGTC_2415 st077333 57.7 µM -0.427256241333017 0.350782532232525 no 2187 0.334596350611426 3375 2766255 SGTC_35 0133-0054 64.071 µM -0.427590682196578 0.350671719890098 no 2188 0.334474575483702 3179 99677 SGTC_868 0527-0199 213 µM -0.427966547108097 0.350547197425527 no 2189 0.334337737997258 3169 2849450 SGTC_125 0133-0007 11.75 µM -0.430087138757381 0.349844955537174 no 2190 0.333566127638085 3305 26541 SGTC_2447 5741742 33.78 µM -0.430383548006184 0.349746839338244 no 2191 0.333458330475698 3250 1776504 SGTC_2807 7945238 51.95 µM -0.430407044696233 0.349739061987437 no 2192 0.333449785863145 3223 17148797 SGTC_1070 indatraline 8.81 µM -0.43225322358865 0.34912817833653 no 2193 0.332778690111041 3190 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_972 1319-0219 195 µM -0.432632580256824 0.349002701038478 no 2194 0.332640858205111 3224 23903702 SGTC_572 0960-0087 17.7 µM -0.432826476876174 0.348938573509557 no 2195 0.332570418353984 3202 6796365 SGTC_2101 5377231 179.231 µM -0.434152589423488 0.348500103364511 no 2196 0.332088819331595 3265 2844213 SGTC_1013 4112-3890 241 µM -0.437225278034562 0.347484918071564 no 2197 0.330973989615778 3103 705171 SGTC_1124 fisetin 1.16336 µM -0.438497402185375 0.347064940581318 no 2198 0.330512876456498 3210 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2730 imipramine 71.33 µM -0.439319494301767 0.346793635955786 no 2199 0.330215025390333 3257 3696 A tricyclic antidepressant. SGTC_2770 toltrazuril 17.5 µM -0.439776828897013 0.34664274161467 no 2200 0.330049375669166 3297 68591 Kills coccidiodes. SGTC_1320 1313-0481 95.3 µM -0.441196028422521 0.346174641658533 no 2201 0.329535544097867 3342 6813365 YLR208W SEC13 SGTC_3183 9108214 49.47 µM -0.441662668614011 0.346020779240509 no 2202 0.329366663825314 3238 4974831 SGTC_2423 st077119 87.2 µM -0.442433018650132 0.345766832058555 no 2203 0.329087945049136 3228 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_27 0485-0001 32.618 µM -0.445048169020609 0.34490526144325 no 2204 0.328142472118002 3240 2054479 SGTC_2518 prenyletin 46.28 µM -0.446037703688258 0.344579465024926 no 2205 0.327785005500564 3259 3873459 A coumarin with calcium channel inhibitory activity. SGTC_883 0850-0245 24.6 µM -0.446533526869713 0.344416262513476 no 2206 0.327605950073277 3358 6823229 YPR165W RHO1 SGTC_2495 cafestol 54.53 µM -0.447500816721525 0.344097957937568 no 2207 0.327256749155028 3328 16667697 An anti-infammatory. SGTC_109 0132-0036 33.701 µM -0.447865954767333 0.343977831224249 no 2208 0.327124970093337 3185 67274 A color developer. SGTC_2103 5378138 10 µM -0.449998755112819 0.343276476487265 no 2209 0.32635566910344 3317 244142 SGTC_2012 4023501 200 µM -0.450853276073333 0.34299562516222 no 2210 0.326047650347631 3234 3477460 SGTC_2177 5811945 192 µM -0.451394687119868 0.342817727046387 no 2211 0.325852555894894 3319 5343475 SGTC_2365 9042475 200 µM -0.451396623367467 0.342817090892106 no 2212 0.32585185826439 3281 6464479 SGTC_2258 7960471 200 µM -0.452652642598613 0.342404519674373 no 2213 0.325399442794682 3240 2974708 SGTC_1716 st033144 30.6155 µM -0.452714615478606 0.342384167980402 no 2214 0.325377126946596 3366 674617 SGTC_2814 7977482 42.97 µM -0.453289198244844 0.342195498652237 no 2215 0.325170254946387 3321 6456762 SGTC_960 1222-0186 7.7 µM -0.453308174339551 0.342189268355464 no 2216 0.325163423737662 3311 3126296 SGTC_328 k915-0120 63.5 µM -0.453950012344969 0.341978563199434 no 2217 0.324932402944573 3288 6624543 SGTC_169 k015-0017 16.025 µM -0.456179522503586 0.341247033328029 no 2218 0.324130444724523 3418 1840002 SGTC_1834 st055981 52.8 µM -0.456325535901261 0.341199145297493 no 2219 0.324077951890615 3361 471719 YDL150W RPC53 SGTC_1575 cyproterone acetate 48 µM -0.456916201854625 0.341005450623365 no 2220 0.323865639064653 3225 9880 An androgen receptor antagonist and liver toxin. SGTC_2482 5981709 142.65 µM -0.457345517806213 0.340864693086122 no 2221 0.323711358887598 3223 877755 SGTC_1118 chelidonine 707.474 nM -0.457419932378906 0.340840297427985 no 2222 0.323684620138773 3307 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_896 0964-0007 44.5 µM -0.459067311626699 0.340300400435626 no 2223 0.323092914820129 3303 6756758 SGTC_2255 7941087 197.44 µM -0.459509098602908 0.34015566880965 no 2224 0.322934309882022 3336 935561 SGTC_1066 ketoconazole 628 nM -0.460382920722792 0.33986946967449 no 2225 0.322620695826747 3333 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1612 st002233 45.4 µM -0.461223784990961 0.339594152192447 no 2226 0.322319029408313 3305 1035021 SGTC_3262 9137218 49.47 µM -0.462328026952982 0.339232729041703 no 2227 0.321923051942757 3223 17650664 SGTC_1026 k007-1105 30.6 µM -0.463347192394206 0.338899283006262 no 2228 0.321557761970463 3290 7066794 SGTC_2315 7733312 200 µM -0.463373304363711 0.338890741464614 no 2229 0.321548405165166 3180 726316 SGTC_2069 5228469 200 µM -0.463993476149574 0.338687900113209 no 2230 0.321326209842995 3296 2835210 SGTC_947 3447-0010 211 µM -0.465137981218847 0.338313686438014 no 2231 0.320916324145394 3302 748350 SGTC_3250 9135583 49.47 µM -0.465506815049266 0.338193124495256 no 2232 0.320784278823175 3328 7699353 SGTC_1256 0570-0116 285 µM -0.465660184380502 0.338142997033836 no 2233 0.320729378106061 3241 410638 SGTC_2617 dihydrotanshinone i 20.83 µM -0.466246733814871 0.33795131481663 no 2234 0.320519450635209 3207 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3132 9126706 49.47 µM -0.466804047324618 0.337769225713369 no 2235 0.320320039954096 3376 850858 SGTC_1655 st012546 55.1 µM -0.468103059039738 0.337344951569563 no 2236 0.319855445894192 3283 720985 YLR208W SEC13 SGTC_426 0988-0037 14.6 µM -0.469259788899223 0.336967322516037 no 2237 0.319441976911078 3375 5383008 SGTC_1989 st071868 50.2 µM -0.469659543274878 0.336836855830531 no 2238 0.319299138275555 3330 16414057 SGTC_1302 1159-0335 255 µM -0.47085641449904 0.336446353838403 no 2239 0.318871637435006 3234 649284 SGTC_1859 st055998 20 µM -0.472588587321443 0.335881511893026 no 2240 0.318253363155608 3379 676301 SGTC_3291 9121177 71.43 µM -0.472796420270504 0.33581376479049 no 2241 0.31817921412528 3247 17015612 SGTC_1545 lovastatin 49.4 µM -0.473068392558204 0.335725118309735 no 2242 0.318082192964068 3301 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1221 2958-7315 257 µM -0.473531992731721 0.335574033825101 no 2243 0.317916840819466 3321 4562705 SGTC_1557 sumaresinolic acid 42.3 µM -0.475132769752353 0.335052554776202 no 2244 0.317346171333525 3243 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1375 2910-0797 186 µM -0.477580875155816 0.334255659678479 no 2245 0.316474272794972 3241 742508 SGTC_1910 st062352 60.4 µM -0.478113082568482 0.334082516822482 no 2246 0.31628486054113 3202 2245730 SGTC_3190 9110366 49.47 µM -0.479575192585261 0.333607030890894 no 2247 0.315764744765387 3303 17123768 SGTC_1970 st070122 35.8 µM -0.482312677670613 0.332717504995799 no 2248 0.314791921313782 3396 102928 SGTC_658 3253-0951 102 µM -0.482366447058462 0.332700042429805 no 2249 0.314772826055512 3287 1184878 SGTC_1271 0832-2808 169 µM -0.483166125203541 0.332440375573723 no 2250 0.314488892818122 3370 3663794 SGTC_796 1234-0020 70.7 µM -0.4858215452414 0.331578700244279 no 2251 0.313546848583862 3307 46495034 SGTC_1250 0485-0349 40.2 µM -0.485906222541124 0.331551237358773 no 2252 0.313516828183354 3236 6842794 YDL195W SEC31 SGTC_387 norethindrone acetate 66.7 µM -0.48687248980585 0.331237917791969 no 2253 0.313174347724477 3284 541197 SGTC_3096 9117468 49.47 µM -0.489549931506395 0.33037035439577 no 2254 0.312226206772774 3323 41316311 SGTC_178 4092-0806 87.505 µM -0.489596127547897 0.33035539361251 no 2255 0.312209858623384 3348 2169044 SGTC_403 arphamenine a 50 µM -0.490141940311743 0.330178650376472 no 2256 0.312016730925779 3294 5487158 An arginine aminopeptidase inhibitor. SGTC_1446 4239-0190 62 µM -0.490203389168819 0.330158754588389 no 2257 0.311994991399686 3246 1340085 SGTC_2754 granisetron 64.02 µM -0.490946171141275 0.329918296129779 no 2258 0.311732260003937 3392 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_988 1497-1057 103 µM -0.491578163950523 0.329713758414216 no 2259 0.311508791560402 3401 3533044 SGTC_140 0062-0056 502.533 µM -0.492026208445129 0.329568784443757 no 2260 0.311350408059801 3233 3758964 SGTC_1383 3049-0032 20.7 µM -0.494477969650556 0.328775920879202 no 2261 0.310484330582527 3389 712864 SGTC_1055 3448-0672 86 µM -0.496919197880425 0.327987228458953 no 2262 0.309623016435334 3380 748378 SGTC_1258 0671-0043 57.1 µM -0.497682343522294 0.327740834568939 no 2263 0.309353977445185 3313 4298767 SGTC_744 1594-0068 283 µM -0.49879717206151 0.327381028971419 no 2264 0.308961140002159 3284 668392 SGTC_145 3737-0113 38.366 µM -0.500144919510127 0.326946263956463 no 2265 0.308486519439923 3390 6849351 SGTC_928 2764-0428 58.7 µM -0.500306095887112 0.326894286354166 no 2266 0.308429781225395 3350 662578 SGTC_2291 7917025 104.35 µM -0.501244666291145 0.32659167450963 no 2267 0.30809947132068 3228 2964612 SGTC_2061 5245884 80.95 µM -0.501613183086168 0.32647288929344 no 2268 0.30796982213039 3281 573863 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.502519040529418 0.326180976118132 no 2269 0.307651231114882 3370 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3333 9141820 12.094 µM -0.502755178035333 0.326104898133548 no 2270 0.307568205122435 3262 1939433 SGTC_1168 k815-0004 80.5 µM -0.502902064490307 0.326057578402062 no 2271 0.307516564788729 3241 642433 SGTC_2302 7771753 200 µM -0.503197031528139 0.325962562708932 no 2272 0.307412875828157 3337 2203047 SGTC_600 1495-0418 41.6 µM -0.503658790366013 0.325813842219098 no 2273 0.307250585904445 3301 5377768 SGTC_2531 methyl deoxycholate 70.07 µM -0.50399634435087 0.32570514240874 no 2274 0.307131972938322 3226 16667744 Haematoxylin. SGTC_3058 9093861 49.47 µM -0.505670835510933 0.325166138627264 no 2275 0.306543872635695 3418 17217477 SGTC_2116 5511452 16.8835 µM -0.506271258379627 0.324972956852231 no 2276 0.306333118484576 3384 870744 SGTC_2093 5331342 194.4 µM -0.506724565286903 0.324827139754721 no 2277 0.306174045870754 3398 33839 SGTC_1945 st075991 56.6 µM -0.50769021107419 0.324516605998886 no 2278 0.305835307223576 3299 1084980 SGTC_1573 oleylamine 1.06 µM -0.510542809724796 0.323599976235974 no 2279 0.304835615384975 3358 5356789 An amine of the fatty acid oleic acid. SGTC_1092 toremifene 6.32 µM -0.511327302494204 0.323348081232348 no 2280 0.304560945080011 3345 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1930 st074634 34.3 µM -0.51152712777164 0.323283931700335 no 2281 0.304490998910496 3275 684253 YOR116C RPO31 SGTC_621 3584-0052 32.1 µM -0.511957158843184 0.323145897457334 no 2282 0.304340496527794 3415 2273927 SGTC_2215 7188065 200 µM -0.512032342264599 0.323121767081052 no 2283 0.304314187216949 3410 940217 SGTC_1588 farnesol 29.9 µM -0.512925565079204 0.322835141137234 no 2284 0.304001694811757 3356 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1666 st014829 29 µM -0.513230825616108 0.32273721030731 no 2285 0.303894932766915 3344 3858230 SGTC_1222 0366-0074 1.18 µM -0.513561605944183 0.32263110633404 no 2286 0.303779264292523 3409 286520 SGTC_122 0236-0016 402.397 µM -0.513931747782073 0.322512393542263 no 2287 0.303649855035646 3398 6808838 SGTC_2569 tetrandrine 100 µM -0.514534928730175 0.322318978649622 no 2288 0.303439023221971 3286 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_103 0844-0104 51.839 µM -0.516916751239709 0.321555698141796 no 2289 0.302607136769425 3420 5375804 SGTC_1146 3579-1023 7 µM -0.517667628039139 0.321315227536354 no 2290 0.302345094078102 3412 X1146 SGTC_2028 5153890 36.43 µM -0.518251710905247 0.321128224975527 no 2291 0.302141329924839 3350 2830968 YPR165W RHO1 SGTC_887 0885-0007 9.62 µM -0.519486889216443 0.320732914211806 no 2292 0.301710626663056 3398 5719458 SGTC_3311 9131146 2.8755 µM -0.519542949024212 0.320714977453162 no 2293 0.301691085313554 3343 4900406 YPR165W RHO1 SGTC_1880 MG-132 525 µM -0.520314452289695 0.320468171693312 no 2294 0.301422212239051 3395 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1814 st052110 31.539 µM -0.520574616541081 0.320384962410489 no 2295 0.301331567910075 3414 674163 SGTC_996 3970-0799 1.8 µM -0.521807552204299 0.319990750936084 no 2296 0.300902165426098 3388 6615648 YGL040C HEM2 SGTC_3139 9095020 49.47 µM -0.521949462265373 0.319945390491826 no 2297 0.300852759204367 3275 25236292 SGTC_1330 1469-0054 61.8 µM -0.522035434258999 0.319917911523914 no 2298 0.300822829692988 3409 7102664 SGTC_2948 9070189 9.45 µM -0.523482337937977 0.31945559043681 no 2299 0.300319319409828 3380 6473636 YDL196W YDL196W SGTC_2238 6671620 73.2395 µM -0.523850340832619 0.319338049234383 no 2300 0.300191318285306 3351 729941 SGTC_2194 5927483 104.545 µM -0.524721563051423 0.319059850685534 no 2301 0.299888382564899 3348 760979 SGTC_1747 st037496 66.6 µM -0.524746984800391 0.319051734545543 no 2302 0.299879545157934 3315 723305 SGTC_3032 9089427 49.47 µM -0.525086217222193 0.318943439607085 no 2303 0.299761628483424 3391 17173707 SGTC_1077 5-fluorocytosine 377 nM -0.525455432569784 0.318825590626362 no 2304 0.299633313658408 3386 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_722 3534-0461 190 µM -0.526024641494039 0.318643942055149 no 2305 0.299435543071206 3372 658262 SGTC_3160 9100216 49.47 µM -0.527514161255604 0.318168805939561 no 2306 0.29891829249107 3374 17191039 SGTC_2140 5586273 200 µM -0.528529376794154 0.317845137598918 no 2307 0.298565981541987 3394 854421 SGTC_487 nimodipine 119 µM -0.528644194723042 0.317808540402168 no 2308 0.298526148087746 3323 4497 L-type voltage-gated calcium channels inhibitor SGTC_518 1021-0119 62.6 µM -0.529010568558315 0.317691773892042 no 2309 0.298399059233324 3301 1097762 SGTC_1925 st057770 10.1 µM -0.52944376962544 0.317553732358463 no 2310 0.29824882092713 3305 5989122 SGTC_273 hydroxyurea 18.1 mM -0.529462703101736 0.31754769969662 no 2311 0.298242255400713 3379 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1730 st033808 45.1 µM -0.529479824228663 0.317542244534679 no 2312 0.298236318395989 3284 1045166 SGTC_348 k064-0012 10.7 µM -0.530427140544949 0.317240470806349 no 2313 0.297907906319743 3339 5066323 SGTC_175 3793-3120 23.7 µM -0.534292118516436 0.316010517610262 no 2314 0.296569722125976 3317 5322297 SGTC_132 0417-1715 25.805 µM -0.534378311987393 0.315983111368824 no 2315 0.296539910488479 3479 6769098 SGTC_312 4092-0653 6.84 µM -0.534630307330436 0.315902992246846 no 2316 0.296452761022553 3396 1148278 SGTC_344 k064-0035 6.43 µM -0.53479108659239 0.315851878783741 no 2317 0.296397163642334 3299 5088750 SGTC_1300 1094-0077 113 µM -0.537584066730952 0.314964522788623 no 2318 0.295432116327263 3357 5532636 SGTC_1628 st004252 77.7 µM -0.538868782583873 0.314556714449703 no 2319 0.294988699422134 3427 692968 SGTC_2051 5263410 176 µM -0.538880437320647 0.31455301591201 no 2320 0.294984678218652 3486 227584 SGTC_541 4513-1321 94 µM -0.539213381395004 0.314447366627954 no 2321 0.294869814059055 3337 747515 SGTC_710 3448-4187 58 µM -0.541942190632598 0.313582038467834 no 2322 0.293929165407481 3447 3946412 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.5423377773128 0.313456679573425 no 2323 0.293792917849487 3351 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1405 3909-7894 12 µM -0.543425076195729 0.313112232520827 no 2324 0.293418582099881 3427 7104060 SGTC_1136 pergolide 1.05886 µM -0.544616066185 0.312735124083836 no 2325 0.293008801293461 3322 47811 A dopamine receptor agonist. SGTC_1943 st076331 65.2 µM -0.544745434630534 0.312694173369718 no 2326 0.292964305822557 3473 24208415 SGTC_1681 tripelennamine 100 µM -0.545232807879855 0.312539919399645 no 2327 0.292796704991948 3444 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2596 sinensetin 100 µM -0.545533795907714 0.312444672879894 no 2328 0.292693221667782 3336 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_603 3794-0023 45.9 µM -0.549073238940078 0.311325570856512 no 2329 0.291477594768336 3435 3802260 SGTC_1489 4065-0444 182 µM -0.550429301918505 0.310897271328497 no 2330 0.291012477717865 3440 2877968 SGTC_3331 9141060 1.957 µM -0.551461283593944 0.310571501315044 no 2331 0.29065875006756 3350 4906567 YPR165W RHO1 SGTC_2369 9071472 200 µM -0.552268243965343 0.310316868166599 no 2332 0.290382292139585 3445 17296037 SGTC_62 0180-0423 3.232 µM -0.553115096728238 0.310049744876535 no 2333 0.290092299874445 3397 30102 YGL099W LSG1 SGTC_3090 9117696 49.47 µM -0.553842441244053 0.309820398142375 no 2334 0.289843339852314 3359 7923821 SGTC_1430 4049-0248 69.1 µM -0.555043537087863 0.309441829869499 no 2335 0.28943244081489 3478 22774488 SGTC_1790 st045711 43.5 µM -0.556242495426436 0.309064136889615 no 2336 0.289022546133417 3506 585119 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.556245761169084 0.309063108398536 no 2337 0.289021430028472 3493 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_514 4466-0038 2.65 nM -0.557350126018595 0.308715393014667 no 2338 0.288644117018326 3402 5722064 SGTC_638 3970-0837 4.09 µM -0.557548858001469 0.308652839340695 no 2339 0.288576243659758 3400 4118451 YLR208W SEC13 SGTC_1609 st001574 46.4 µM -0.557602172569789 0.308636058778358 no 2340 0.288558036300635 3365 3960012 SGTC_2320 7373003 200 µM -0.557815363370468 0.308568961759955 no 2341 0.288485235316523 3423 5415828 SGTC_2704 st078022 71.1 µM -0.557833453838761 0.30856326848536 no 2342 0.288479058131825 3492 54697681 SGTC_1470 k295-0292 231 µM -0.558514939139668 0.308348830901361 no 2343 0.288246403073834 3470 5045612 SGTC_554 4483-2211 187 µM -0.558894517755445 0.308229420246245 no 2344 0.288116855561112 3424 747107 SGTC_564 3555-0129 330 µM -0.56073416691603 0.307650977444387 no 2345 0.287489385800328 3419 563260 SGTC_2157 5649910 96.377 µM -0.560874976984273 0.307606722058344 no 2346 0.28744138476736 3401 2858091 SGTC_282 k297-0036 65.7 µM -0.561120446623896 0.307529579769484 no 2347 0.287357715183156 3468 5061378 SGTC_2035 5154463 94.595 µM -0.562166536521743 0.307200926752472 no 2348 0.287001279320559 3478 2769623 SGTC_1420 4'-methoxyflavone 42 µM -0.562541282099504 0.307083229522046 no 2349 0.286873642634289 3458 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_485 niflumic acid 177 µM -0.565501141066883 0.306154318794673 no 2350 0.285866474187732 3476 4488 A COX2 inhibitor. SGTC_1464 k208-0027 110 µM -0.570457986312378 0.304601471571766 no 2351 0.284183555028915 3516 X1464 SGTC_2296 7971656 126.45 µM -0.572785870427295 0.303873418688348 no 2352 0.28339484358584 3441 666570 SGTC_3237 9133362 49.47 µM -0.573239441467757 0.303731653352031 no 2353 0.283241291225941 3449 43845137 SGTC_3125 9127534 49.47 µM -0.577329032344345 0.302454771505114 no 2354 0.281858602495718 3407 1639235 SGTC_2628 lathosterol 100 µM -0.57862572097809 0.302050413091021 no 2355 0.281420872800719 3533 6710616 SGTC_2300 7976697 71.57 µM -0.578674306868679 0.302035266822705 no 2356 0.281404477795656 3392 2236109 SGTC_1976 st070609 63.5 µM -0.578691342731629 0.302029956107515 no 2357 0.281398729259342 3451 682556 SGTC_2141 5621638 7.665 µM -0.580111840861694 0.301587281372045 no 2358 0.28091959962625 3501 2856238 SGTC_194 1486-1323 56.904 µM -0.580306812684354 0.301526544415561 no 2359 0.280853867020597 3455 5178754 SGTC_1694 st024011 44.9 µM -0.580590243051285 0.301438260972298 no 2360 0.280758324853384 3532 2787533 SGTC_578 3460-0051 92 µM -0.580882458994555 0.301347253163033 no 2361 0.280659837596268 3538 2876744 SGTC_2205 7238770 200 µM -0.582205554231637 0.300935342943999 no 2362 0.280214116304679 3502 279867 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.585781638118979 0.299823297714879 no 2363 0.27901113226362 3499 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2887 9044784 58.44 µM -0.586540788073885 0.299587466500569 no 2364 0.278756080047296 3498 6465546 SGTC_3084 9116877 49.47 µM -0.588407367616817 0.299007968163505 no 2365 0.278129446829927 3443 27241325 SGTC_2424 5537928 59.2 µM -0.588748599465722 0.298902084371929 no 2366 0.27801496551774 3463 5382802 SGTC_277 nystatin 15.5 µM -0.58926525224343 0.298741800125882 no 2367 0.277841675270359 3436 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1736 st036774 51 µM -0.589595852445926 0.298639256573274 no 2368 0.277730816497605 3562 1272247 SGTC_213 1246-0773 967 nM -0.592508955738934 0.297736380701818 no 2369 0.276754912732532 3461 6251622 SGTC_2406 ethylparaben 405.7 µM -0.593271651247656 0.297500199690211 no 2370 0.276499683810579 3273 8434 A possible steroid mimic. SGTC_2989 9073649 71.4286 µM -0.59332941090824 0.297482316961222 no 2371 0.276480359782015 3515 21367202 SGTC_3119 9125183 49.47 µM -0.595199221899272 0.29690367787192 no 2372 0.275855155177045 3378 22695334 SGTC_1199 1638-0010 4.46 µM -0.595413816263361 0.296837301611285 no 2373 0.2757834461882 3443 3111136 SGTC_3024 9090631 49.47 µM -0.596147922017689 0.296610286467715 no 2374 0.275538206235996 3487 25236383 SGTC_948 3448-0295 75.3 µM -0.600027274434556 0.295411956784598 no 2375 0.274244029311816 3541 678569 SGTC_2902 5787006 60.46 µM -0.601310926801099 0.295015928289966 no 2376 0.273816456564219 3466 591003 SGTC_991 3996-0057 64.7 µM -0.603302231604596 0.294402061506797 no 2377 0.273153824329949 3501 715343 SGTC_817 1391-0715 46 µM -0.604999204275388 0.293879395436781 no 2378 0.272589762706881 3458 1353946 SGTC_2456 5770359 74.46 µM -0.607896030108479 0.29298816872635 no 2379 0.271628216360766 3536 3118787 SGTC_3040 9091894 49.47 µM -0.608035254310377 0.292945367124933 no 2380 0.271582046096871 3466 25236966 SGTC_688 0527-0193 473 µM -0.610292761104866 0.292251748683309 no 2381 0.270833945666525 3490 4007154 SGTC_2249 haloperidol 116.36 µM -0.610536104293071 0.292177027181045 no 2382 0.27075336721044 3543 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1771 st048882 4.1505 µM -0.611835939079513 0.291778047650469 no 2383 0.270323154529107 3421 4580403 SGTC_1791 st048313 56.1 µM -0.614077615029351 0.291090570483893 no 2384 0.269582019830851 3509 1204976 SGTC_1899 st063254 59.6 µM -0.614247370807441 0.291038540612574 no 2385 0.269525937293501 3488 3093813 SGTC_1567 st069303 68.4 µM -0.615365756319722 0.290695865906047 no 2386 0.269156600371019 3551 5581319 SGTC_781 4335-2806 94.4 µM -0.616600978004105 0.290317611903836 no 2387 0.268748974648135 3594 845254 SGTC_3270 9137563 49.47 µM -0.617051096486801 0.290179832335638 no 2388 0.26860051174382 3491 17015724 SGTC_2236 dapsone 200 µM -0.617801005245863 0.289950356159125 no 2389 0.268353260368564 3564 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2129 girgensonine 121.053 µM -0.61844395119235 0.289753678966336 no 2390 0.268141366736491 3540 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3150 9097574 49.47 µM -0.618660258783314 0.289687524540541 no 2391 0.268070097872687 3528 17217476 SGTC_353 1988-1175 58.3 µM -0.618812423448338 0.289640991512365 no 2392 0.268019968486173 3423 2788357 SGTC_2136 5328288 199.296 µM -0.620500189268158 0.289125096258423 no 2393 0.267464264719856 3493 262395 SGTC_2310 7668677 200 µM -0.620570597671101 0.289103584086087 no 2394 0.26744109509852 3596 2197143 SGTC_1327 1436-0082 2.18 µM -0.621869582631057 0.288706834920526 no 2395 0.267013813762919 3505 15992205 SGTC_2360 9040895 200 µM -0.622133730143121 0.288626187688985 no 2396 0.266926968657042 3481 4914414 SGTC_1104 tacrolimus 29.8 µM -0.62411629799948 0.288021226216209 no 2397 0.266275605614615 3587 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2038 4100038 30.985 µM -0.624346778178992 0.287950936263379 no 2398 0.266199934702953 3545 3596803 SGTC_1983 st071813 46.9 µM -0.625089776209936 0.287724397978404 no 2399 0.265956068827251 3527 11838595 SGTC_1968 st069590 43.6 µM -0.625471726931834 0.287607974917011 no 2400 0.265830749505495 3527 6384066 SGTC_2266 7929956 200 µM -0.625763507061112 0.287519051915583 no 2401 0.265735035627842 3564 2967153 SGTC_1924 st058459 75.1 µM -0.628582752828166 0.28666052805098 no 2402 0.264811127287374 3544 688683 SGTC_1562 morin hydrate 59.1 µM -0.62863521753549 0.286644562893618 no 2403 0.264793949320951 3590 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_136 0097-0015 404.482 µM -0.629768093167807 0.286299928564859 no 2404 0.264423162029615 3592 4861337 SGTC_1203 3992-3522 103 µM -0.631315762802644 0.285829427144872 no 2405 0.26391704118588 3716 5322312 SGTC_1398 3558-0053 112 µM -0.631405670599763 0.28580210590658 no 2406 0.263887654610274 3483 4532369 SGTC_1987 st072290 61.9 µM -0.633009234761605 0.285315022557684 no 2407 0.263363806224244 3539 54697379 SGTC_2898 9056270 58.44 µM -0.633122793823765 0.285280543939176 no 2408 0.263326729171631 3507 19154699 SGTC_1377 2944-0135 198 µM -0.634784849844793 0.284776140454566 no 2409 0.2627843727685 3611 1894137 SGTC_2747 doxorubicin 7.63 µM -0.636078698087177 0.284383776118505 no 2410 0.262362564510523 3478 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_813 k007-0158 173 µM -0.636958543481476 0.284117107345418 no 2411 0.262075923764957 3573 6523916 SGTC_2977 9011197 71.43 µM -0.640203180104039 0.28313473867943 no 2412 0.261020257802661 3602 2704722 SGTC_1158 4092-0494 91.8 µM -0.640556101453061 0.283027984124636 no 2413 0.260905564269007 3632 1148199 SGTC_2066 5222451 176 µM -0.641277968358739 0.282809688075721 no 2414 0.260671050357109 3596 2281147 SGTC_611 3453-1652 23.7 µM -0.642538818294795 0.282428595061441 no 2415 0.260261696663004 3593 1560575 SGTC_465 cgp-37157 41 µM -0.643154843057212 0.282242490887331 no 2416 0.260061815581922 3503 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1553 gossypol 38.6 µM -0.644918515363247 0.28171000322251 no 2417 0.259489996174282 3531 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_550 4123-0385 25.7 µM -0.644921468206649 0.281709112106763 no 2418 0.259489039345544 3581 5731123 SGTC_583 1488-1091 88.9 µM -0.645912940519961 0.281409980212235 no 2419 0.259167869279825 3660 4303273 SGTC_281 1672-3440 14.9 µM -0.646565265859361 0.281213254203209 no 2420 0.258956672059267 3587 6833000 SGTC_1914 st062367 72.6 µM -0.648626994139759 0.280591922355272 no 2421 0.258289751544016 3571 978205 SGTC_3272 9137413 49.47 µM -0.650276492716401 0.28009530072689 no 2422 0.25775681932594 3555 17614870 SGTC_3003 9075612 71.4286 µM -0.651875972012074 0.279614145798148 no 2423 0.257240593307265 3593 6501993 SGTC_1396 3511-0007 98.6 µM -0.653277318945624 0.279192923003651 no 2424 0.256788755885313 3554 X1396 SGTC_2936 9038235 15.59 µM -0.65562910951335 0.27848670576493 no 2425 0.256031395590595 3608 4749415 SGTC_720 r052-1644 49.9 µM -0.659464405435562 0.277336878199509 no 2426 0.254798797950271 3600 1422863 YOR257W CDC31 SGTC_420 mitomycin C 81.9 mM -0.660236946388339 0.277105550457497 no 2427 0.254550893097052 3600 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1670 st016595 4.04 µM -0.66076972081116 0.276946072840415 no 2428 0.254380001871514 3605 597879 SGTC_1241 0364-0022 50.8 µM -0.661661652971052 0.276679187650218 no 2429 0.254094042875031 3605 4563895 SGTC_845 0330-0138 4.51 µM -0.662106129711018 0.276546237764593 no 2430 0.253951603845614 3586 9039800 SGTC_3214 9129694 49.47 µM -0.663141953198452 0.276236528487132 no 2431 0.253619821834266 3582 17158655 SGTC_2504 purpurogallin 52.29 µM -0.663324212473424 0.276182050920512 no 2432 0.253561466389532 3580 5281571 An antioxidant. SGTC_2575 plumbagin 510 nM -0.664651205936006 0.275785569647089 no 2433 0.253136804756335 3584 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1801 st050089 28.441 µM -0.668416240564029 0.274662171408973 no 2434 0.251933965757478 3648 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_829 1635-0120 117 µM -0.668598706284568 0.27460778529743 no 2435 0.25187574903346 3625 285054 SGTC_2463 5473429 200 µM -0.66987296593258 0.274228124968248 no 2436 0.251469387293518 3584 5399405 SGTC_3215 9129942 49.47 µM -0.670206687112152 0.27412873699142 no 2437 0.251363020798346 3570 17682944 SGTC_1035 k081-0041 55.2 µM -0.670321730281979 0.274094479257719 no 2438 0.251326358759367 3661 731709 SGTC_1524 corynanthine 62.1 µM -0.670375495139522 0.274078469800255 no 2439 0.251309225905763 3650 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2466 5983409 37.09 µM -0.670806000367108 0.273950295756049 no 2440 0.251172062226216 3598 2879657 SGTC_615 k087-0205 167 µM -0.671811254519204 0.273651117498545 no 2441 0.250851931483543 3607 9642773 SGTC_459 nigericin 15.3 µM -0.672102338958675 0.273564516726261 no 2442 0.250759273798938 3684 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_196 k015-0023 18.111 µM -0.672173067802003 0.273543476177957 no 2443 0.250736762206902 3618 5211998 SGTC_3195 9113082 49.47 µM -0.672474683960332 0.273453759831493 no 2444 0.250640775762463 3600 17018038 SGTC_1191 1487-1166 10.6 µM -0.673864852350559 0.273040439780621 no 2445 0.2501986197376 3689 3955771 SGTC_3173 9105693 49.47 µM -0.674091542179299 0.272973070523966 no 2446 0.250126558170637 3681 17096658 SGTC_1909 st060837 51.5 µM -0.676613159516195 0.272224234977343 no 2447 0.249325713748395 3607 678937 SGTC_3321 9137793 26.8275 µM -0.676670242941456 0.272207294944028 no 2448 0.249307600325322 3627 4904192 SGTC_1647 st011722 22.4 µM -0.681853511003552 0.270671299430294 no 2449 0.24766579199885 3644 2854783 SGTC_1367 1812-0510 76.9 µM -0.68332128430789 0.270237131184764 no 2450 0.247201923820469 3649 1142582 YDR527W RBA50 SGTC_2974 9094440 9.66 µM -0.684329607165897 0.269939070589536 no 2451 0.246883527621141 3698 25236134 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.685213209710326 0.269678012704366 no 2452 0.246604694670364 3648 616764 SGTC_199 4063-0024 41.6 µM -0.687730664238872 0.268934931950936 no 2453 0.245811203010514 3680 306215 SGTC_334 1502-1024 68.5 µM -0.688898565874253 0.26859055011562 no 2454 0.245443550996833 3687 3296216 SGTC_361 000s-0510 1.45 µM -0.689228350469584 0.268493345919173 no 2455 0.245339789295194 3654 660 SGTC_2241 6772625 37.8075 µM -0.691585526799838 0.267799082233207 no 2456 0.244598826669307 3602 2285411 SGTC_111 0083-0039 52.457 µM -0.691604441227305 0.267793514990391 no 2457 0.244592885923722 3581 759313 SGTC_1522 st012842 45.6 µM -0.691683037730485 0.267770381643915 no 2458 0.244568200741709 3583 3491067 YOR116C RPO31 SGTC_3247 9135149 49.47 µM -0.691820816320957 0.267729831635012 no 2459 0.244524931194843 3632 8934436 YOR116C RPO31 SGTC_2339 9000433 200 µM -0.691917070749619 0.267701504556426 no 2460 0.244494704812417 3647 2988954 SGTC_759 3486-0358 89.3 µM -0.692820815930874 0.267435611669051 no 2461 0.24421100362884 3679 875103 SGTC_537 1334-0398 209 µM -0.695187951847352 0.266739803260023 no 2462 0.243468760888769 3656 5846986 SGTC_3086 9117350 49.47 µM -0.696890020074466 0.266240054468335 no 2463 0.242935811926311 3598 2679265 SGTC_2000 st075254 36.4 µM -0.698120952310642 0.265878932725953 no 2464 0.242550777958057 3646 17234175 SGTC_2927 9011802 47.9 µM -0.700785405183477 0.265098106415064 no 2465 0.241718473794175 3661 43912568 SGTC_1024 4507-0395 26 µM -0.701224094729229 0.264969658824897 no 2466 0.241581587637006 3705 4201836 SGTC_1895 st058434 18.3 µM -0.701472928766248 0.264896814680043 no 2467 0.241503961611261 3684 5393175 SGTC_1457 k015-0032 57.3 µM -0.703914916710449 0.264182483007165 no 2468 0.240742880692546 3680 4302660 SGTC_2327 6189656 200 µM -0.705252041877865 0.26379176252255 no 2469 0.240326699934481 3732 5349088 SGTC_3356 9151811 4.48 µM -0.705255753978517 0.263790678222319 no 2470 0.240325545087483 3657 1859254 YPR165W RHO1 SGTC_1435 4092-0789 56.7 µM -0.70530045267441 0.263777621964314 no 2471 0.240311639410236 3690 2248285 SGTC_1497 4476-2978 41.3 µM -0.708231828797552 0.262922102213965 no 2472 0.239400651745228 3705 1528379 SGTC_2663 amphotericin b 100 µM -0.711555211234963 0.261953894496692 no 2473 0.238370125175475 3684 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2192 5915882 198.485 µM -0.711799831358459 0.261882701120861 no 2474 0.238294368580019 3655 2876149 SGTC_662 k832-1615 104 µM -0.71322742168838 0.261467418299715 no 2475 0.237852520192343 3717 5878478 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.714716156566703 0.261034709120314 no 2476 0.237392226141136 3744 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_349 k015-0014 24 µM -0.717691480050575 0.260171019083056 no 2477 0.236473768874318 3700 2196908 SGTC_2148 5546263 113.568 µM -0.718035851135957 0.260071148714965 no 2478 0.236367590850459 3707 792097 SGTC_1350 1495-0454 146 µM -0.71921759950021 0.259728582595593 no 2479 0.236003428589934 3712 1069057 SGTC_202 3594-0513 34.79 µM -0.719328138503901 0.259696551379046 no 2480 0.235969381207013 3690 708429 SGTC_203 k066-0004 30.888 µM -0.719424137199258 0.259668735205316 no 2481 0.235939814615639 3768 6795412 SGTC_1297 1068-0111 14.1 µM -0.72120825731919 0.259152056174841 no 2482 0.235390696078065 3668 767057 SGTC_2444 5485484 36.41 µM -0.722997748903656 0.258634355965428 no 2483 0.234840633606271 3782 6790631 SGTC_2891 9063876 19.48 µM -0.724390258420267 0.258231873498286 no 2484 0.234413089383196 3703 6472478 SGTC_1977 st070720 65.3 µM -0.725822884841033 0.257818134969072 no 2485 0.233973677873965 3720 682188 SGTC_3127 9126946 49.47 µM -0.727585721751135 0.257309505075699 no 2486 0.233433611792819 3700 27243249 SGTC_2124 5246320 200 µM -0.728890346039416 0.25693341897599 no 2487 0.233034370294362 3734 579342 SGTC_3299 9121982 43.1275 µM -0.72892645968034 0.256923012509369 no 2488 0.233023324183633 3768 17594604 YPL160W CDC60 SGTC_1469 k284-2957 126 µM -0.731080317188586 0.256302756136673 no 2489 0.232365047979537 3732 23884841 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.731203534069604 0.256267296415681 no 2490 0.232327420927087 3733 521171 SGTC_2570 licareol 100 µM -0.731515174554556 0.256177623004018 no 2491 0.232232269609232 3732 443158 SGTC_2816 7982706 58.44 µM -0.732440631598808 0.255911422589926 no 2492 0.231949833223406 3747 2981853 SGTC_2870 9038528 12.99 µM -0.732541078150057 0.255882538618495 no 2493 0.231919189869578 3698 6463316 SGTC_300 r073-0011 5.04 µM -0.73272116486525 0.255830757929273 no 2494 0.23186425623723 3747 2735780 SGTC_3269 9137823 49.47 µM -0.73303789413127 0.255739701407412 no 2495 0.231767658760406 3674 17682936 SGTC_1403 3909-7815 62.9 µM -0.733742302132675 0.255537251773523 no 2496 0.231552905729383 3681 6615483 SGTC_1985 st071382 65.5 µM -0.734789617099286 0.255236404173354 no 2497 0.231233815731077 3751 6123237 SGTC_185 k048-0037 25.491 µM -0.736089395340678 0.25486329265053 no 2498 0.230838148019756 3737 6827589 SGTC_1157 4092-0394 27.6 µM -0.737149975936135 0.254559056325598 no 2499 0.230515575191935 3813 3659885 SGTC_1242 0402-0103 60.1 µM -0.738348799813816 0.254215392973742 no 2500 0.230151259559827 3699 432868 SGTC_2143 5623677 140.463 µM -0.739117906727766 0.253995043507813 no 2501 0.229917702138724 3698 5375313 SGTC_1759 st043059 70 µM -0.739398917121173 0.253914558911884 no 2502 0.229832399821358 3742 669426 SGTC_17 0960-0276 49.807 µM -0.739897813367299 0.253771702293553 no 2503 0.22968100066624 3731 6821114 SGTC_898 1000-0849 28.3 µM -0.740044657727489 0.253729662134095 no 2504 0.229636448712705 3681 6751807 SGTC_2847 9005661 71.43 µM -0.741444996073196 0.253328942224447 no 2505 0.22921183529799 3682 2991449 SGTC_921 1561-0023 372 µM -0.741692762319395 0.253258076252125 no 2506 0.229136752985591 3725 24050882 SGTC_3216 9129716 49.47 µM -0.743807783942193 0.252653563387843 no 2507 0.22849638517579 3731 8056934 SGTC_1571 st070080 73.4 µM -0.745905716182937 0.252054686638834 no 2508 0.22786218598417 3802 4315245 SGTC_727 3032-0951 202 µM -0.746789919893721 0.251802505946931 no 2509 0.227595190592717 3742 3652836 SGTC_3244 9134489 49.47 µM -0.747916383265452 0.251481424268632 no 2510 0.227255297436739 3738 16584271 SGTC_369 0957-0393 4.5 µM -0.747916465403952 0.251481400864162 no 2511 0.227255272663132 3770 6997992 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.74823303662447 0.251391205897433 no 2512 0.227159803643795 3815 688788 SGTC_9 0092-0002 10.449 µM -0.748770490087964 0.251238118075083 no 2513 0.226997774504162 3734 759368 SGTC_245 methotrexate 289.6 µM -0.749295515679746 0.251088617811818 no 2514 0.226839555013612 3743 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_264 promethazine 12.5 mM -0.749516673797251 0.251025657454101 no 2515 0.226772926366092 3756 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_88 0180-0332 8.668 µM -0.750655590817936 0.250701557392407 no 2516 0.226429977983342 3821 3101745 SGTC_1654 st012436 41.8 µM -0.751465542449338 0.250471205470947 no 2517 0.226186265301245 3713 4323132 SGTC_2313 7726885 200 µM -0.752366213008719 0.250215184668923 no 2518 0.225915429629295 3764 726423 SGTC_1698 5-fluorocytosine 1.055 µM -0.752384859489866 0.250209885765797 no 2519 0.225909824487002 3772 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2374 9071832 200 µM -0.752800030370192 0.250091919120168 no 2520 0.225785044265116 3705 17381698 SGTC_1649 st011737 51.3 µM -0.754351715752385 0.249651284605386 no 2521 0.225319028209451 3772 1761035 SGTC_558 k064-0027 21.3 µM -0.757144460764723 0.248859264584019 no 2522 0.224481659901168 3805 5088526 SGTC_973 1325-0077 65.9 µM -0.759811743565141 0.248104076119604 no 2523 0.223683561116078 3804 2835149 SGTC_2820 7989630 71.43 µM -0.759814928869143 0.248103174995054 no 2524 0.22368260898156 3651 2984098 SGTC_3343 9148379 18.9835 µM -0.760146855590064 0.248009282283154 no 2525 0.223583403803509 3811 1955036 SGTC_2252 omeprazole 400 µM -0.760260175887663 0.247977231507438 no 2526 0.223549540732324 3706 4594 A proton pump inhibitor. SGTC_2953 9074162 66.49 µM -0.761602533760834 0.247597735960686 no 2527 0.22314863106825 3705 16451992 SGTC_2543 pimpinellin 60.67 µM -0.762129680585168 0.247448792123209 no 2528 0.222991304988418 3677 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_889 0919-1524 82.7 µM -0.76601296740707 0.246353057565848 no 2529 0.221834293213478 3828 3905452 SGTC_12 0849-0099 9.267 µM -0.766140879319108 0.246317009369551 no 2530 0.221796240728893 3692 6071388 SGTC_1810 st050138 53 µM -0.766894725622947 0.246104617493936 no 2531 0.221572054924383 3738 3444541 SGTC_1471 k673-0312 37 µM -0.76690078759382 0.246102909966609 no 2532 0.221570252684346 3766 24099884 SGTC_2174 5790901 200 µM -0.767201868409048 0.246018109947239 no 2533 0.221480751101264 3824 786020 SGTC_2854 9024559 71.43 µM -0.768079340415976 0.245771057630446 no 2534 0.221220024994032 3802 3163529 SGTC_1307 1187-1599 12.2 µM -0.768275288593337 0.245715906602696 no 2535 0.221161826266201 3795 1538471 SGTC_2391 6285546 200 µM -0.768646051240958 0.245611570966423 no 2536 0.221051729721727 3777 846083 SGTC_772 k072-0172 35.3 µM -0.769705074015667 0.24531368440741 no 2537 0.220737429774508 3823 5861980 SGTC_959 1222-0044 107 µM -0.771216230991994 0.244888956056976 no 2538 0.220289387556093 3733 6083612 SGTC_1436 4092-1007 8.32 µM -0.77245492360821 0.244541102363259 no 2539 0.219922517350457 3779 2881121 SGTC_3351 9150312 21.596 µM -0.772713169552275 0.244468614440115 no 2540 0.219846075462808 3752 4904905 SGTC_3148 9097893 49.47 µM -0.774168679452064 0.244060279051638 no 2541 0.219415523696197 3785 17174100 SGTC_7 0192-1582 4.227 µM -0.7752769895382 0.243749595562294 no 2542 0.219088001639835 3835 252616 SGTC_2257 7960413 200 µM -0.776390188074384 0.243437756770259 no 2543 0.218759318139668 3781 2974689 YIL048W NEO1 SGTC_2198 6589944 200 µM -0.776518042314897 0.243401954940327 no 2544 0.218721586015217 3789 5290268 SGTC_3329 9141233 27.5565 µM -0.776893918009745 0.243296718455306 no 2545 0.218610679918852 3779 4909101 YNL103W MET4 SGTC_2013 4024628 200 µM -0.777157190910783 0.243223022790616 no 2546 0.218533017750094 3815 5230760 SGTC_1034 k072-0165 12.7 µM -0.779542092453326 0.24255598841967 no 2547 0.217830226144827 3786 5835461 SGTC_776 4476-4378 112 µM -0.7803158801233 0.242339780393009 no 2548 0.217602483929915 3866 2892008 SGTC_570 0987-0065 62.6 µM -0.781249918952374 0.242078934933565 no 2549 0.217327759507547 3629 3104428 SGTC_278 4092-0821 23.9 µM -0.782451773236243 0.241743521782641 no 2550 0.216974558631049 3811 877900 SGTC_2025 5147754 141 µM -0.783478260532557 0.241457249830481 no 2551 0.216673157450935 3797 315777 YLR208W SEC13 SGTC_2853 9015042 58.44 µM -0.783562563281032 0.241433747239929 no 2552 0.216648414916198 3754 6457456 SGTC_738 1315-0003 72.4 µM -0.784298327430391 0.24122867781974 no 2553 0.216432540333228 3808 6251474 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.784429956119219 0.241192000751502 no 2554 0.216393933360205 3834 688798 SGTC_1982 st072467 71.9 µM -0.785566341971358 0.24087548384122 no 2555 0.21606079476696 3801 3163533 SGTC_2755 lomerizine 42.69 µM -0.785776811937102 0.240816886571156 no 2556 0.215999126806596 3813 3949 A calcium channel blocker. SGTC_2964 9083345 53.42 µM -0.786176254128753 0.240705698581218 no 2557 0.215882117794066 3801 17741579 SGTC_695 3505-6186 243 µM -0.787334498133329 0.240383449949908 no 2558 0.215543039925236 3804 1819379 SGTC_750 4073-0104 132 µM -0.788731541256903 0.239995075098353 no 2559 0.215134464456432 3659 22330957 SGTC_412 gemfibrozil 100 µM -0.789735131832694 0.239716290490423 no 2560 0.214841234761027 3769 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2794 7785382 27.27 µM -0.790500219041729 0.239503877832674 no 2561 0.214617847175791 3759 2205081 SGTC_2658 polymyxin b sulfate 77.05 µM -0.790602599783396 0.239475461465285 no 2562 0.214587964636895 3834 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_644 1498-1197 63.3 µM -0.792995761768608 0.238811750253629 no 2563 0.213890146037089 3888 6741615 SGTC_3170 9103054 49.47 µM -0.793422753959565 0.238693435595917 no 2564 0.213765779055283 3832 16432970 SGTC_1338 1486-1223 76 µM -0.794004463719533 0.238532302091952 no 2565 0.213596416376419 3859 3444526 SGTC_1841 st054148 70 µM -0.794020269624763 0.238527924689997 no 2566 0.213591815635929 3862 675442 SGTC_507 nimesulide 162 µM -0.795317030846992 0.23816894007918 no 2567 0.213214554590337 3851 4495 A COX2 inhibitor. SGTC_126 0417-1624 672.48 µM -0.796127729093286 0.23794466358001 no 2568 0.212978899250641 3886 41912 YDL195W SEC31 SGTC_2702 st077768 96.8 µM -0.797180659485049 0.237653547439442 no 2569 0.212673058390266 3803 6484119 SGTC_2836 9010338 19.48 µM -0.797327530483708 0.237612955810575 no 2570 0.212630417695996 3826 2994051 SGTC_1192 1488-0095 21.4 µM -0.797485550606304 0.237569287079617 no 2571 0.212584545680173 3875 915875 SGTC_866 0495-0101 262 µM -0.797612594254388 0.237534181866072 no 2572 0.212547670086351 3804 635694 SGTC_2831 7999036 19.48 µM -0.798827434185782 0.23719863621617 no 2573 0.212195240286761 3901 2988270 SGTC_2978 9011784 42.97 µM -0.799399556831431 0.23704070294376 no 2574 0.212029383670709 3858 2994934 SGTC_2879 9041815 71.43 µM -0.801759018099916 0.236389989546176 no 2575 0.21134618453211 3827 4942971 SGTC_304 1310-0298 97 µM -0.802217243365735 0.236263730200536 no 2576 0.211213651767793 3757 1550234 SGTC_2104 5389443 200 µM -0.802573297894721 0.236165648614328 no 2577 0.211110703534739 3890 2244536 SGTC_2753 fluvastatin 17.09 µM -0.802986309703529 0.236051905228939 no 2578 0.210991323742444 3879 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1614 st002383 48.6 µM -0.803128241198489 0.236012824287909 no 2579 0.21095030801932 3822 1947235 SGTC_94 0334-0113 514.748 µM -0.80343629411337 0.235928013960675 no 2580 0.210861302192773 3853 6795178 SGTC_872 0588-0139 234 µM -0.80367855066051 0.235861329891759 no 2581 0.210791322403396 3821 2047100 SGTC_679 0422-0091 41.4 µM -0.803786057116808 0.235831740757439 no 2582 0.210760271758964 3834 627384 YHR062C RPP1 SGTC_1570 verbenone 133 µM -0.804097504161338 0.235746032356781 no 2583 0.210670332944999 3861 29025 A natural terpanoid with antifungal properties. SGTC_1579 chlormadinone acetate 49.4 µM -0.805741294806303 0.235293955492726 no 2584 0.210196016819932 3873 45114258 A steroidal progestin. SGTC_1993 st073995 70.8 µM -0.807629134278853 0.234775351089412 no 2585 0.209652054915814 3832 3098394 SGTC_2873 9040596 71.43 µM -0.807637666408203 0.234773008681404 no 2586 0.209649598349487 3800 6463863 SGTC_2329 6138490 200 µM -0.808710466431795 0.234478585476451 no 2587 0.209340853210605 3965 720019 SGTC_2246 7293507 91.5585 µM -0.808772341642667 0.234461610447718 no 2588 0.209323054077283 3890 887656 SGTC_2176 5809774 33.9695 µM -0.808836453281371 0.234444022587988 no 2589 0.20930461254872 3845 2870539 SGTC_551 k048-0028 34.9 µM -0.810461575686913 0.233998443725218 no 2590 0.208837470173136 3816 6836383 SGTC_3155 9099265 49.47 µM -0.810757039266354 0.233917483438141 no 2591 0.208752605040672 3863 25236499 SGTC_1427 4048-4900 550 nM -0.811400501731403 0.233741221323902 no 2592 0.20856785555593 3850 24132586 SGTC_974 1326-0144 138 µM -0.817163673653291 0.232165816529977 no 2593 0.206917449511216 3903 5411856 SGTC_1733 st037357 54.9 µM -0.820538799328758 0.231245952314321 no 2594 0.205954510116054 3791 1272339 YGL099W LSG1 SGTC_3047 9092122 49.47 µM -0.821138784160158 0.231082644228523 no 2595 0.205783610272485 3844 17173831 SGTC_1765 st044815 90.4 µM -0.823030024518065 0.230568294591035 no 2596 0.205245459804473 3913 645695 SGTC_2863 9028737 58.44 µM -0.82554830498796 0.229884406720889 no 2597 0.204530185105763 3844 6460917 SGTC_24 0417-1663 219 µM -0.82640657281469 0.229651587176445 no 2598 0.204286748078193 3823 4329390 SGTC_2567 aureobasidin a 60 nM -0.826823610636292 0.229538506369799 no 2599 0.204168522778137 4036 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2092 5303694 80.6725 µM -0.828074835000559 0.229199421166205 no 2600 0.203814060057381 3860 1963699 SGTC_75 0159-0059 199.013 µM -0.828330384262597 0.229130201182285 no 2601 0.20374170995399 3905 5377270 SGTC_2389 9091542 195.52 µM -0.829373778506943 0.228847701317818 no 2602 0.203446467191827 3872 3626624 YOL127W RPL25 SGTC_2200 6600604 21.907 µM -0.830728161013291 0.228481292875816 no 2603 0.203063606937497 3835 2904777 SGTC_2210 7115885 190.385 µM -0.832783263715081 0.227925944794663 no 2604 0.202483487660578 3921 2927039 SGTC_2292 7671323 168.05 µM -0.833189109792027 0.227816363329317 no 2605 0.202369041735895 3928 937504 SGTC_183 3914-0051 30.55 µM -0.834186653881214 0.227547145024728 no 2606 0.20208790530816 3911 1596232 SGTC_164 4100-3994 89.624 µM -0.834333789218941 0.227507451143552 no 2607 0.202046458153425 3839 4615967 SGTC_3349 9149703 23.001 µM -0.835240682640731 0.227262877336601 no 2608 0.201791103971883 3860 4910494 SGTC_1397 3532-0190 20.1 µM -0.836016455299537 0.227053782211938 no 2609 0.201572822929359 3796 5322280 SGTC_2146 5545642 200 µM -0.839263773862446 0.226179706038707 no 2610 0.200660653516866 3858 825326 SGTC_3136 9095672 49.47 µM -0.840879710418643 0.225745456151639 no 2611 0.200207663019867 3646 17217380 SGTC_1811 st050069 61.5 µM -0.841329193988855 0.225624750528966 no 2612 0.200081770010205 3829 3877702 SGTC_970 1315-0089 19.5 µM -0.841877260172112 0.225477620670787 no 2613 0.199928330024304 3835 6811083 YLR033W RSC58 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.842970621593302 0.225184267124496 no 2614 0.199622437287635 3871 7104 SGTC_598 3937-0236 20.2 µM -0.843204698964883 0.225121491273816 no 2615 0.19955698543663 3954 1379313 SGTC_846 0335-0850 148 µM -0.846873521358723 0.224138867566236 no 2616 0.198532811374669 3896 6819598 SGTC_1908 st060353 56.5 µM -0.847806210403728 0.223889453593253 no 2617 0.198272951928647 3944 4227716 SGTC_2884 9058502 51.95 µM -0.848214250531548 0.223780387623925 no 2618 0.198159331160085 3917 6471554 SGTC_935 2996-0153 430 µM -0.848314795748818 0.223753517303876 no 2619 0.198131339890376 3899 23738523 SGTC_556 4058-0063 51.5 µM -0.850280520027253 0.223228553699719 no 2620 0.197584572092036 3950 6615692 SGTC_376 3970-0862 59.1 µM -0.851006343505302 0.223034893655618 no 2621 0.197382914498262 3939 3135186 SGTC_2941 9056145 11.23 µM -0.851430472175495 0.222921774388403 no 2622 0.197265135266783 3761 2119517 SGTC_1142 3253-1408 9.78 µM -0.852331316697738 0.22268161879803 no 2623 0.197015114592955 3850 256655 SGTC_927 2425-1185 123 µM -0.853131247718298 0.222468489346087 no 2624 0.19679326233861 3868 730375 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.855175090267446 0.221924467242528 no 2625 0.196227112079017 3949 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_323 4013-0906 34.3 µM -0.855301087487223 0.221890954668537 no 2626 0.196192242833838 3935 2910086 SGTC_3052 9092717 49.47 µM -0.858598528612248 0.221014933789903 no 2627 0.19528102508571 3914 25237534 SGTC_728 3030-5151 22.5 µM -0.858737352751964 0.220978096287314 no 2628 0.195242718796164 3943 3125388 SGTC_1934 st074720 32.6 µM -0.859253573947418 0.220841145905307 no 2629 0.195100315918392 3864 17250992 SGTC_2384 9036245 200 µM -0.861415040515329 0.220268249816972 no 2630 0.194504747608105 3889 6462766 SGTC_1128 3448-9350 235 µM -0.86235106526878 0.220020421379222 no 2631 0.194247180015529 3977 619386 SGTC_1176 0848-0131 83.3 µM -0.86455054507121 0.219438701811783 no 2632 0.193642763275485 3978 6769040 SGTC_1952 st077036 64.1 µM -0.866243683510944 0.218991502227402 no 2633 0.193178271196781 3924 2937007 SGTC_875 0709-0210 25.7 µM -0.868833842092347 0.218308392830675 no 2634 0.192469009882285 3921 6251364 SGTC_780 0109-0199 192 µM -0.870346049929154 0.217910142474033 no 2635 0.192055660121919 4024 610414 SGTC_42 0133-0086 60.653 µM -0.870971273172638 0.217745608117626 no 2636 0.191884919258939 3825 162923 Model of phenazepam hydroxylation. SGTC_2866 9034245 58.44 µM -0.87295478502556 0.217224099803146 no 2637 0.191343861584022 3907 6462273 SGTC_2007 4011539 71.82 µM -0.874062565178293 0.216933154619457 no 2638 0.191042091269085 3914 45595301 SGTC_49 0717-0965 32.132 µM -0.874296891237858 0.216871640562347 no 2639 0.190978295942921 3968 5889349 YGL099W LSG1 SGTC_646 4092-0839 27.3 µM -0.87466763543226 0.216774335328339 no 2640 0.190877387442194 3982 877796 SGTC_828 2074-0507 139 µM -0.875671958888644 0.216510868231014 no 2641 0.190604196824155 4026 X828 SGTC_2849 9019321 12.99 µM -0.875719817771124 0.216498317897648 no 2642 0.190591184504757 3951 16489627 SGTC_2412 st077135 33.4 µM -0.87595347746383 0.216437049903382 no 2643 0.190527662758897 4044 13258915 SGTC_1840 st055363 71 µM -0.877573815104436 0.216012456713681 no 2644 0.190087522246447 3983 676033 SGTC_1490 4089-0339 670 nM -0.881146526889792 0.215077970291246 no 2645 0.189119258630034 3874 742542 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.881208608637433 0.215061752826092 no 2646 0.189102460349354 4029 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1827 berberine 7.24 µM -0.882132622504927 0.21482045885262 no 2647 0.188852546313703 3886 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_452 diindolylmethane 8 µM -0.882318717938115 0.214771881531607 no 2648 0.188802238519287 3948 3071 Inhibits expression of several cancer promoting factors. SGTC_616 4092-0450 108 µM -0.882982790102905 0.214598587844487 no 2649 0.188622785021084 3963 787165 SGTC_1207 2099-0101 141 µM -0.883623828687075 0.214431382032386 no 2650 0.18844965571598 3979 5837381 SGTC_937 3122-0005 46.7 µM -0.884999005572567 0.214072942352902 no 2651 0.188078583849437 4010 759535 SGTC_3009 9080819 71.4286 µM -0.890102350453194 0.212745808064303 no 2652 0.186705465504984 3971 17027216 SGTC_2648 atorvastatin 78.68 µM -0.890932944534868 0.212530265953404 no 2653 0.186482572507051 3963 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_664 1222-0054 14.9 µM -0.891231065932265 0.212452933512231 no 2654 0.186402610734819 3921 6813991 SGTC_135 0933-0004 26.348 µM -0.891619212904938 0.212352273151455 no 2655 0.186298534241719 3957 21230617 YGL099W LSG1 SGTC_2910 7948405 25.97 µM -0.891661303939631 0.212341359119421 no 2656 0.186287250250027 3855 2971328 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.891661307883618 0.212341358096777 no 2657 0.186287249192721 4010 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3095 9117207 49.47 µM -0.892595414422997 0.212099232488469 no 2658 0.186036937865356 3935 17015229 SGTC_2718 lomofungin 53.02 µM -0.892952634204878 0.212006681823558 no 2659 0.185941269281773 3920 5351222 A RNA synthesis inhibitor. SGTC_2525 harmine 47.85 µM -0.895435739170586 0.211363996963206 no 2660 0.185277101466152 3956 5280953 A monoamine oxidase inhibitor SGTC_2448 5185112 27.17 µM -0.895606130684845 0.211319937587203 no 2661 0.185231580117898 4003 5718189 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.895710988286645 0.211292826467052 no 2662 0.185203570089714 3961 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_60 0986-0278 202 µM -0.895717892662118 0.21129104139995 no 2663 0.18520172585459 3912 3110598 SGTC_584 0986-0246 15.4 µM -0.896636949739073 0.211053505938764 no 2664 0.184956337346266 4048 53315 YDR232W HEM1 SGTC_2695 st077686 51.995 µM -0.897183067754241 0.210912432842203 no 2665 0.184810619414351 4001 2876092 SGTC_393 acivicin 6.25 µM -0.900699881896097 0.210005295457224 no 2666 0.183873955752421 3825 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3073 9114972 49.47 µM -0.901501942455477 0.209798731105319 no 2667 0.183660750751124 3947 41905075 SGTC_2765 myclobutanil 7.74 µM -0.903699172553146 0.209233464048659 no 2668 0.183077469001058 4019 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2739 tacrine 100.86 µM -0.90445684310763 0.209038751157829 no 2669 0.182876604289065 4026 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3081 9117243 49.47 µM -0.904564881538947 0.209010995180472 no 2670 0.182847973618917 3986 45595589 SGTC_2976 9009005 19.48 µM -0.904918516965431 0.208920158460796 no 2671 0.182754278208307 3999 2993148 SGTC_1974 st069448 26.9 µM -0.905081487293376 0.208878304845058 no 2672 0.182711109447174 3958 6323587 YNR016C ACC1 SGTC_2189 6047310 154.431 µM -0.906474071011512 0.208520866614435 no 2673 0.182342491457143 3940 711535 SGTC_1400 3771-8998 51.5 µM -0.907898120408409 0.208155725237311 no 2674 0.181966025386293 3884 670767 SGTC_2595 hexamethylquercetagetin 100 µM -0.910885900055319 0.207390854290869 no 2675 0.18117774780699 3960 386331 SGTC_92 0063-0024 660.874 µM -0.911205583900505 0.207309113812058 no 2676 0.181093531226676 4056 3594437 SGTC_532 1548-0774 215 µM -0.911488742468248 0.207236728452236 no 2677 0.181018957243821 4125 5932993 SGTC_319 1348-1596 45.5 µM -0.91184585257517 0.207145459775288 no 2678 0.180924934473331 4089 5380505 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.913197364206 0.206800261532526 no 2679 0.180569374981303 3998 1377 SGTC_1303 1160-0052 261 µM -0.914914451447237 0.206362180816335 no 2680 0.180118271385691 3954 3562476 SGTC_2935 9038016 29.96 µM -0.915388481025601 0.206241338515896 no 2681 0.179993861694149 3989 6463195 SGTC_2001 4023502 57.655 µM -0.916410032980913 0.205981061356341 no 2682 0.179725937519504 4013 108941 YCR052W RSC6 SGTC_1525 8-methoxypsoralen 92.5 µM -0.916642771886511 0.205921789996591 no 2683 0.179664931753054 4058 4114 Related to psoralen; DNA damaging agent. SGTC_1322 1348-1070 12 µM -0.916886907743357 0.20585962706155 no 2684 0.179600952590751 3946 6758089 SGTC_69 0096-0274 206.684 µM -0.917907988411918 0.205599755737134 no 2685 0.179333519543207 4151 6741392 SGTC_2686 alizarin 95.37 µM -0.919630553918481 0.205161793843449 no 2686 0.178882927219199 4009 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_805 3852-0218 479 µM -0.919714883420648 0.20514036733028 no 2687 0.178860886441219 3934 6615355 SGTC_1669 st015249 58.4 µM -0.920849862933594 0.204852120158962 no 2688 0.178564408886477 4068 722793 SGTC_893 0958-0369 48.9 µM -0.922292404075272 0.204486110328542 no 2689 0.178188037533931 3961 6819948 SGTC_3201 9113999 49.47 µM -0.923044300929933 0.204295489136143 no 2690 0.177992059580164 4037 16649224 SGTC_613 3914-0030 117 µM -0.927089424924394 0.20327178477121 no 2691 0.176940053155067 3729 1145395 SGTC_2557 derrustone 83.84 µM -0.928178375207054 0.202996726702654 no 2692 0.176657524889299 4002 629853 An antioxidant. SGTC_2496 diffractaic acid 79.83 µM -0.931173963670704 0.20224121826776 no 2693 0.175881791803579 4018 94870 An apoptosis inducer which activates caspases. SGTC_1149 3909-7961 23.3 µM -0.931438006134224 0.20217470566719 no 2694 0.175813519376325 4029 735261 SGTC_1950 st077106 7.18 µM -0.932230235334773 0.2019752207761 no 2695 0.17560877652793 3988 13831864 SGTC_1165 k072-0275 30.3 µM -0.935326433374587 0.201196722659121 no 2696 0.174810048397318 3990 6153523 YGL055W OLE1 SGTC_1514 1189-1591 158 µM -0.93560334385805 0.201127184938048 no 2697 0.174738726137576 4053 767698 YMR146C TIF34 SGTC_454 lyso-paf C-16 6.67 µM -0.936798040085834 0.200827338266669 no 2698 0.174431226834451 3994 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2286 7945697 125 µM -0.936853248505769 0.200813488461676 no 2699 0.174417025217902 4045 1245733 SGTC_3174 9107204 49.47 µM -0.936977276556707 0.200782376379288 no 2700 0.174385123364152 4067 3938802 SGTC_3162 9099653 49.47 µM -0.937520025394372 0.200646263416508 no 2701 0.174245563922489 4002 25237511 SGTC_2827 7993847 71.43 µM -0.93866243952986 0.200359944808791 no 2702 0.173952041848756 4088 2985692 SGTC_1686 st019653 115.5 µM -0.939938147171052 0.200040509640139 no 2703 0.173624644274892 3986 97252 SGTC_2860 9025725 38.96 µM -0.940444591998945 0.199913781606235 no 2704 0.173494779080081 4029 40546248 SGTC_3068 9116768 49.47 µM -0.943123771982992 0.199244172227999 no 2705 0.172808798882476 4012 41904888 SGTC_2439 5492030 7.2 µM -0.94377487750206 0.199081645213793 no 2706 0.172642350563048 3999 5722370 SGTC_2149 5554786 194.827 µM -0.944255292795839 0.19896177660946 no 2707 0.172519602970915 4046 745063 YPR165W RHO1 SGTC_1081 sertraline 6 µM -0.945294844265785 0.198702546654119 no 2708 0.172254184924372 4018 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3186 9110464 49.47 µM -0.9470565664819 0.198263696368003 no 2709 0.171804977674616 4038 17018021 SGTC_809 3998-0021 90 µM -0.947063741882138 0.198261910151354 no 2710 0.171803149608682 3976 715485 SGTC_1270 0831-1170 17.3 µM -0.947119157443808 0.198248115540896 no 2711 0.171789031887768 4004 6764716 SGTC_568 1193-0097 7.48 µM -0.95042256771021 0.197426843733536 no 2712 0.170948790703734 3894 3646150 SGTC_483 fpl-64176 144 µM -0.950985256387255 0.197287157182787 no 2713 0.170805930150107 4081 3423 SGTC_2050 5263056 171 µM -0.951283843846554 0.19721305761614 no 2714 0.170730153069057 4054 763468 YGL055W OLE1 SGTC_635 k038-0028 24.7 µM -0.952034266148228 0.19702690188376 no 2715 0.170539801999241 4033 4035102 SGTC_1523 st012844 44.7 µM -0.952543340598281 0.196900677389487 no 2716 0.170410748278642 4148 4274103 SGTC_247 mechlorethamine 29.705 µM -0.952860979332094 0.196821943996688 no 2717 0.170330256468379 3924 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1280 0880-0253 10.1 µM -0.954198304054723 0.196490669283209 no 2718 0.169991636482527 4033 6836607 SGTC_1315 1237-0019 3.69 µM -0.955939907407334 0.196059755777556 no 2719 0.169551297699412 4070 825140 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.956496603360746 0.195922137130636 no 2720 0.169410699803247 3997 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_50 0929-0078 56.389 µM -0.957676258306097 0.195630712957461 no 2721 0.169113016107423 3910 1377751 SGTC_3327 9140648 26.9345 µM -0.958894237510987 0.195330097392431 no 2722 0.168806014025667 4064 8029710 SGTC_1994 st072947 40.9 µM -0.959299383068275 0.195230163618443 no 2723 0.168703973042969 4100 5286565 YDL195W SEC31 SGTC_1495 4469-0029 237 µM -0.95934696763507 0.195218428381306 no 2724 0.16869199087585 4049 793680 SGTC_3071 9117417 49.47 µM -0.959771899595595 0.195113651282015 no 2725 0.168585013927411 3985 45595590 YGL055W OLE1 SGTC_639 0833-0042 114 µM -0.960281530116963 0.194988034824659 no 2726 0.168456771579791 4044 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_128 0906-2981 13.371 µM -0.960546781722259 0.194922673650638 no 2727 0.168390049053554 3992 6740226 SGTC_1767 st044992 70.3 µM -0.964367937769144 0.193982574055449 no 2728 0.167430745435666 4102 9600693 SGTC_2886 9058944 51.95 µM -0.965657898015637 0.193665836498739 no 2729 0.167107696706419 3894 4949929 SGTC_154 3389-1638 511.116 µM -0.96849177150054 0.192971113872168 no 2730 0.166399413265058 4059 5238686 SGTC_3069 9117009 49.47 µM -0.971498042719414 0.192235794019907 no 2731 0.165650163661777 4027 41904981 SGTC_3033 9090887 49.47 µM -0.97325133182876 0.191807740075147 no 2732 0.165214202139616 4093 19325384 SGTC_706 4262-0057 46.9 µM -0.974155196069726 0.191587295748231 no 2733 0.164989743464483 4047 883298 SGTC_1143 3454-2408 5.08 µM -0.974256429002077 0.191562615618031 no 2734 0.164964616360422 4017 X1143 SGTC_1485 3909-9022 254 µM -0.975195716652006 0.191333714424887 no 2735 0.164731593217335 4085 714516 SGTC_2799 7812892 81.82 µM -0.975698219027791 0.19121132517163 no 2736 0.164607017532615 4099 20205235 SGTC_377 3970-0964 33.1 µM -0.977040573931271 0.190884617239543 no 2737 0.16427453291198 4017 16481235 SGTC_1225 1216-0074 20.6 µM -0.978123057131343 0.190621407557894 no 2738 0.164006732679386 4082 4241466 SGTC_2766 oltipraz 83.91 µM -0.979486222462528 0.190290266110059 no 2739 0.163669896423086 4027 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1239 0337-0584 35.4 µM -0.979722928139496 0.190232801365119 no 2740 0.163611452576562 4139 914301 YML130C ERO1 SGTC_3049 9092223 49.47 µM -0.979976464386312 0.190171262510224 no 2741 0.163548868207507 4052 8623917 SGTC_766 1391-0721 126 µM -0.981136221892259 0.189889919691676 no 2742 0.163262785112886 4113 1020919 YIL115C NUP159 SGTC_113 0099-0221 2.5 µM -0.981361706520453 0.189835249639443 no 2743 0.163207201485256 3988 89219 SGTC_863 0466-0191 129 µM -0.985072300589306 0.188936985247853 no 2744 0.16229427908858 4106 765160 YPR165W RHO1 SGTC_2802 7925815 54.55 µM -0.986833298122738 0.188511598988011 no 2745 0.161862183985625 4051 1262923 SGTC_366 0181-0206 4.31 µM -0.98707458015714 0.188453360979818 no 2746 0.161803039169671 4101 274874 SGTC_77 0828-0286 12.516 µM -0.987298458028599 0.188399333722941 no 2747 0.161748173186534 3987 745345 SGTC_2142 5622915 118.518 µM -0.988606961760027 0.188083750606799 no 2748 0.161427739368116 4092 5322196 SGTC_1456 k015-0012 13 µM -0.98922864357391 0.187933928650861 no 2749 0.161275643556046 4060 2989616 SGTC_3200 9114385 49.47 µM -0.991475017491873 0.187393179106451 no 2750 0.160726842669515 4134 17018030 YLR208W SEC13 SGTC_642 0335-0876 158 µM -0.99241993649049 0.18716600484911 no 2751 0.160496358823938 4114 6812350 SGTC_3050 9093513 49.47 µM -0.992690096089073 0.187101085306287 no 2752 0.160430501435246 4055 25236664 SGTC_971 1315-0384 26.7 µM -0.993214997754853 0.186974990889464 no 2753 0.160302595510831 4114 6769120 SGTC_1285 0929-0069 65.5 µM -0.994129773759446 0.18675536466624 no 2754 0.160079845905883 4100 1206237 SGTC_3151 9099821 49.47 µM -0.996177200217812 0.186264382276726 no 2755 0.159582027615801 4059 17174189 SGTC_651 3253-0966 34.4 µM -0.99670032573711 0.186139062745965 no 2756 0.159454995771639 4095 781462 SGTC_1675 st018485 24.5 µM -0.996911496235178 0.186088489719519 no 2757 0.159403735485164 4132 3323024 SGTC_2393 9031399 185.94 µM -0.998793776568114 0.185638080549274 no 2758 0.158947300719833 4145 1526623 YDL150W RPC53 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.00132691449751 0.185032996974849 no 2759 0.158334392488237 4117 165521 SGTC_2650 prasterone 100 µM -1.00642631936016 0.183818637699372 no 2760 0.157105269148281 4074 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1269 0831-0796 3.05 µM -1.00735920769695 0.183597020389247 no 2761 0.156881093371822 4125 927758 SGTC_1781 st038725 66.3 µM -1.01252683187968 0.182372415504268 no 2762 0.155643112056896 4080 4270275 YIL048W NEO1 SGTC_1940 st075990 51.1 µM -1.01311452853669 0.182233469201372 no 2763 0.155502729741158 4200 1084979 SGTC_1785 bathophenanthroline 24 µM -1.01362205993727 0.18211352923943 no 2764 0.155381563632949 4023 72812 An iron chelator. SGTC_1772 st048439 82.2 µM -1.01417719382942 0.181982396365553 no 2765 0.155249104446362 4162 2927068 YDL195W SEC31 SGTC_622 1348-1566 26.3 µM -1.01606297296309 0.181537381624315 no 2766 0.154799699921918 4134 7340407 SGTC_1202 1988-0068 29.6 µM -1.01791710742427 0.181100499208565 no 2767 0.154358675448502 4085 2850480 SGTC_1257 0669-0121 16 µM -1.01812728489342 0.181051017514614 no 2768 0.154308735106356 4128 4307855 SGTC_1140 3229-1848 2.98 µM -1.02302510331566 0.179900332654597 no 2769 0.153147988400011 4141 2849525 SGTC_455 paf C-16 10 µM -1.0235865350642 0.179768724921347 no 2770 0.153015303879752 4091 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3303 9125618 40.5795 µM -1.02489947332651 0.179461189363491 no 2771 0.15270531158009 4130 22695467 SGTC_3144 9087057 49.47 µM -1.02500605762265 0.179436238156706 no 2772 0.152680164706803 3979 17249618 SGTC_2263 7948595 193.29 µM -1.02612680930762 0.179174004095183 no 2773 0.15241590744604 4095 2971371 SGTC_3060 1327-0027 12.5 µM -1.02788301162643 0.178763572062939 no 2774 0.152002430849648 4019 16000455 YPR107C YTH1 SGTC_384 k007-0144 5.16 µM -1.0284015459379 0.178642501632578 no 2775 0.151880490816212 4067 6824886 SGTC_3326 9140064 16.379 µM -1.02977226005566 0.17832270798644 no 2776 0.151558462757272 4043 1868434 SGTC_2268 7933382 153.85 µM -1.03000104973548 0.178269365496936 no 2777 0.151504756401111 4136 935025 YOR257W CDC31 SGTC_1029 k015-0030 64.7 µM -1.03004156937859 0.178259919359304 no 2778 0.151495246091911 4177 2208316 SGTC_1674 st016616 23.6 µM -1.03261731941086 0.177660095339838 no 2779 0.150891509909576 4067 625830 SGTC_106 0092-0003 11.579 µM -1.03345832883527 0.177464522623019 no 2780 0.150694731009886 4038 1072148 SGTC_1467 k284-1082 293 µM -1.03426550724757 0.177276945010193 no 2781 0.150506028649563 4083 3334705 SGTC_2130 NSC 7 2.4545 µM -1.03494332956938 0.177119524798353 no 2782 0.150347688825561 4198 21448 SGTC_3305 9127027 53.8275 µM -1.03718090763715 0.176600487717057 no 2783 0.149825777099995 4060 41905295 SGTC_2736 butenafine 14.65 µM -1.03834580112026 0.176330655725985 no 2784 0.149554546328915 4069 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2997 9067075 71.4286 µM -1.03993972999655 0.175961866348 no 2785 0.149183951311043 4143 27209819 SGTC_3233 9132340 49.47 µM -1.04014160623293 0.175915192854336 no 2786 0.14913705804942 4129 17682950 SGTC_589 1227-0070 34.1 µM -1.04035855595041 0.175865043134507 no 2787 0.149086674387141 4204 2841384 SGTC_2350 9023895 38.85 µM -1.04159442662614 0.175579534149362 no 2788 0.148799876871697 4154 2997209 SGTC_2994 9053520 71.4286 µM -1.04555737711304 0.174666001784997 no 2789 0.147882718381514 4185 4647384 SGTC_2262 9014885 67.46 µM -1.04560638077807 0.174654724468456 no 2790 0.147871401044193 4094 6457424 SGTC_3114 9122766 49.47 µM -1.04700088856364 0.174333997241279 no 2791 0.147549584187207 4142 17176985 SGTC_2787 5284540 71.43 µM -1.04717228865038 0.174294602236074 no 2792 0.147510061818139 4187 736958 SGTC_2843 9000894 45.46 µM -1.05013883209887 0.173613661150438 no 2793 0.146827143681987 4067 2242070 SGTC_2894 9048625 32.47 µM -1.05043257945333 0.173546326541701 no 2794 0.146759636668592 4141 4092861 SGTC_965 1291-5240 308 µM -1.05140541118357 0.173323446637173 no 2795 0.14653621581434 4168 2834598 SGTC_1171 0368-0077 21.4 µM -1.05408139999687 0.17271130676405 no 2796 0.145922825537101 4093 3239779 SGTC_1719 st032227 49.2 µM -1.0588226502262 0.171630121262585 no 2797 0.144840278104868 4153 3125804 SGTC_2515 chrysin 20.77 µM -1.06304655552761 0.170670560421987 no 2798 0.143880419631208 4176 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1201 1889-3372 45.9 µM -1.07204544085609 0.168637725417988 no 2799 0.141849811284885 4034 5392199 SGTC_1556 plumbagin 1.48 µM -1.0731689265935 0.168385028915679 no 2800 0.141597664906323 4093 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2248 tofa 1.1 µM -1.07425883657917 0.168140117164769 no 2801 0.141353344350985 4131 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1032 k061-1018 98.7 µM -1.07431446392491 0.168127623392524 no 2802 0.141340882270489 4260 4005393 SGTC_2324 6149169 200 µM -1.07577961773593 0.167798768335621 no 2803 0.141012914967591 4074 2888231 SGTC_3105 9121040 49.47 µM -1.07877169037509 0.167128482433966 no 2804 0.140344758936421 4044 41448907 SGTC_1286 0929-0070 131 µM -1.08014211067569 0.166822057261562 no 2805 0.140039451077754 4243 1420408 SGTC_3027 9089541 49.47 µM -1.08073369853122 0.16668989063932 no 2806 0.139907794264312 4185 9943819 SGTC_754 3474-0146 171 µM -1.08228378357247 0.166343906764783 no 2807 0.139563224706677 4148 24762078 SGTC_1389 3405-0187 19 µM -1.08258835369745 0.166275980300341 no 2808 0.139495589483366 4127 799890 SGTC_2479 5617353 43.85 µM -1.08293280635925 0.166199180660335 no 2809 0.139419124500134 4219 2731746 SGTC_1954 st077032 68.9 µM -1.08359470919931 0.166051666220751 no 2810 0.139272268860142 4145 698907 SGTC_29 0299-0004 12.984 µM -1.08438654052324 0.165875306547271 no 2811 0.139096724455594 4068 16871 A napthoquinone isolated from Swertia calycina. SGTC_891 0929-0073 133 µM -1.086443381408 0.165417765062393 no 2812 0.138641438719596 4217 5603632 SGTC_1347 1493-0251 600 nM -1.08710600660359 0.16527053903393 no 2813 0.138494981793289 4235 3986378 SGTC_3263 9137018 49.47 µM -1.08804839266719 0.16506130016804 no 2814 0.138286872286614 4151 43844957 SGTC_1299 1079-1439 3.74 µM -1.0886245782959 0.164933453652217 no 2815 0.138159736818328 4140 323161 SGTC_3260 9137109 49.47 µM -1.08891268502074 0.16486955136251 no 2816 0.138096195912509 4120 17478346 SGTC_165 k038-0023 64.381 µM -1.08988126846741 0.164654836408876 no 2817 0.137882724435307 4181 46368543 SGTC_1959 st077091 55.8 µM -1.08998808345842 0.164631168827664 no 2818 0.137859196676501 4178 821356 YKL052C ASK1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.0918984634025 0.164208247805598 no 2819 0.137438866596386 4168 676296 Flavone; oxidizing agent. SGTC_694 1315-0438 43.2 µM -1.09194971395282 0.164196911642022 no 2820 0.137427602293205 4181 6793154 SGTC_16 erodoxin 22.806 µM -1.09218751976981 0.164144317762534 no 2821 0.137375343457501 4213 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1789 tunicamycin 25 nM -1.09440898218737 0.163653540026311 no 2822 0.136887823134004 4098 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_263 alizarin 107.927 µM -1.09470050173696 0.163589206703385 no 2823 0.13682393437088 4212 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1114 scopoletin 1.73284 µM -1.09501772282951 0.163519220153578 no 2824 0.136754436076334 4221 5280460 A coumarin with genotoxic properties. SGTC_438 sphingosine 6.67 µM -1.0952649195843 0.163464696126938 no 2825 0.136700295777263 4141 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1511 0906-3109 28.5 µM -1.09569647160883 0.163369537283049 no 2826 0.136605813661908 4205 2882180 SGTC_1001 4048-4355 44.4 µM -1.09572698907854 0.163362809428838 no 2827 0.136599133991369 4170 21824233 SGTC_153 4077-0274 519.67 µM -1.09696333232998 0.16309039764771 no 2828 0.13632871071142 4214 3121976 SGTC_1123 mangostin 811.285 nM -1.09798111901974 0.16286636359644 no 2829 0.136106366992229 4194 5281650 An antioxidant. SGTC_1354 1498-1681 81 µM -1.09984601875303 0.162456383503176 no 2830 0.135699608937213 4201 5754243 SGTC_900 1112-0045 141 µM -1.09995886946241 0.162431595940199 no 2831 0.135675021526239 4069 56211 YIL048W NEO1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.10015221231942 0.162389134066307 no 2832 0.135632903937229 4251 6710655 SGTC_1019 4262-0212 3.4 µM -1.10157237099513 0.16207746089207 no 2833 0.135323812706062 4222 4677213 SGTC_422 cantharidin 155 µM -1.1015922145264 0.162073108720357 no 2834 0.135319497272634 4117 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_76 0433-0009 400.328 µM -1.10384843144078 0.161578761492274 no 2835 0.134829445906118 4261 2841569 SGTC_439 amiodarone 34.4 µM -1.10388655340047 0.16157041725375 no 2836 0.134821176272278 4059 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3336 9143619 71.43 µM -1.10624946502169 0.161053765072818 no 2837 0.134309279114499 4240 45595730 SGTC_2647 atorvastatin 60.16 µM -1.10827198730852 0.160612396554157 no 2838 0.133872184790678 4169 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3354 9151612 71.43 µM -1.10842600020577 0.160578819217656 no 2839 0.133838940632151 4213 27261949 SGTC_390 dec-rvkr-cmk 16.7 µM -1.11084354256954 0.160052356277298 no 2840 0.133317850194645 4250 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2685 mycophenolic acid 18.85 µM -1.1115999770419 0.159887861265944 no 2841 0.133155091210344 4185 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1454 4239-0054 42.6 µM -1.11178897530218 0.159846778784006 no 2842 0.133114446570216 4306 1340767 SGTC_3284 9108171 64.8615 µM -1.11285176649709 0.159615888856374 no 2843 0.132886049168145 4182 8687505 SGTC_2725 haloperidol 53.21 µM -1.11320302789337 0.159539625813976 no 2844 0.132810621275196 4140 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1220 1838-0075 193 µM -1.12061040498026 0.15793695132601 no 2845 0.131226867029811 4113 5529645 SGTC_1944 st076371 56.9 µM -1.1209400327082 0.15786587896145 no 2846 0.131156694505495 4175 24208455 SGTC_1734 st037168 69.4 µM -1.12218487698455 0.157597662524906 no 2847 0.130891920663486 4244 708907 SGTC_1491 4138-0063 26.5 µM -1.12377788531588 0.157254867014229 no 2848 0.130553632717826 4185 23883227 SGTC_3065 9113888 49.47 µM -1.12467082626625 0.15706293184042 no 2849 0.130364274277585 4280 16648368 SGTC_3308 9128332 17.569 µM -1.1254380922776 0.156898133275594 no 2850 0.130201718487423 4222 17332805 YDL196W YDL196W SGTC_1830 st055982 50.3 µM -1.12926545622129 0.156077766048643 no 2851 0.129392934232296 4186 455313 An antimicrobial agent. SGTC_2684 capsaicin 100 µM -1.12970613675546 0.15598349122435 no 2852 0.129300035259616 4242 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2382 9035899 200 µM -1.13088716472548 0.155731018929835 no 2853 0.129051293133224 4215 6462679 SGTC_1145 3546-0597 10.2 µM -1.13119638184999 0.155664961090661 no 2854 0.128986222234836 4192 875334 SGTC_654 1124-0271 80.9 µM -1.13213051580888 0.15546551495898 no 2855 0.128789783569052 4191 5403748 SGTC_2385 9074692 200 µM -1.13216132879551 0.155458938978609 no 2856 0.128783307455842 4246 17046906 SGTC_179 1273-0063 6.77 µM -1.13242392182371 0.155402904905322 no 2857 0.128728126185775 4186 3108139 SGTC_2220 6782180 200 µM -1.13285618214409 0.155310694979634 no 2858 0.128637326781427 4146 833803 SGTC_2275 7947463 200 µM -1.13411585607315 0.155042186870493 no 2859 0.128372976674317 4194 1225414 SGTC_1813 st051246 8.6015 µM -1.1347573467371 0.154905566616697 no 2860 0.128238501056707 4166 5291959 SGTC_2056 5235370 200 µM -1.13703947170773 0.154420180189833 no 2861 0.127760892621152 4152 5511916 SGTC_790 1575-0012 79.1 µM -1.13729553018775 0.154365781777167 no 2862 0.127707381347135 4282 378741 YLR208W SEC13 SGTC_1766 st045414 44.774 µM -1.1394038289865 0.153918365368955 no 2863 0.127267379832247 4240 253960 SGTC_2541 muurolladie-3-one 83.07 µM -1.14176508103208 0.153418287826349 no 2864 0.126775840297965 4216 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_399 oxolinic acid 75 µM -1.14505018880368 0.152724343766164 no 2865 0.126094183820111 4198 4628 A DNA gyrase inhibitor. SGTC_2435 5706476 10.6 µM -1.14515235371282 0.15270279594974 no 2866 0.126073025752709 4222 5725375 SGTC_1106 tegaserod maleate 11.7 µM -1.1466668898475 0.152383598482066 no 2867 0.125759659840789 4252 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_724 3910-0327 137 µM -1.14729966790978 0.15225036801444 no 2868 0.125628895614904 4287 2885483 SGTC_3149 9097855 49.47 µM -1.15051348117336 0.151574898583985 no 2869 0.124966222459961 4248 25236625 YMR079W SEC14 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.15546757184213 0.150537570996003 no 2870 0.123949502358323 4294 91467 include heat shock SGTC_1169 aniline yellow 25.8 µM -1.15706878496366 0.150203309587741 no 2871 0.123622129331843 4165 6051 A DNA damaging agent. SGTC_2634 4'-methoxyflavone 100 µM -1.15716332666732 0.150183589003404 no 2872 0.123602818933417 4260 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_232 clozapine 119 µM -1.15818574633051 0.149970431328657 no 2873 0.123394121893363 4215 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1610 st001799 48.1 µM -1.1584568077787 0.149913953325622 no 2874 0.123338834057464 4189 621897 SGTC_167 3672-0051 66.205 µM -1.15847249447776 0.149910685300096 no 2875 0.123335635005666 4162 3237971 SGTC_1971 st069429 63.5 µM -1.15886238666393 0.149829473940929 no 2876 0.123256141398516 4243 1246522 YGL099W LSG1 SGTC_1822 st052468 42 µM -1.16095082307596 0.149394969315236 no 2877 0.122830949411827 4238 2873678 SGTC_1552 6-methylflavone 10.6 µM -1.16506764723617 0.148540918952144 no 2878 0.121995805728862 4196 689013 SGTC_490 phenamil 164 µM -1.16555491057782 0.148440050865063 no 2879 0.121897223500907 4230 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2486 5283202 22.39 µM -1.16749933321147 0.148037993327432 no 2880 0.121504388717074 4293 1377751 SGTC_1498 4478-3555 97.6 µM -1.1694341668328 0.14763864266703 no 2881 0.12111437540628 4236 3437919 SGTC_1961 st076550 68.7 µM -1.17014916017744 0.147491250430293 no 2882 0.120970473992139 4287 1579337 SGTC_2654 protoveratrine a 100 µM -1.17252839325326 0.147001493699666 no 2883 0.120492489749236 4258 5702278 A heart drug and vasodilator. SGTC_1305 1181-0477 144 µM -1.17281610388674 0.146942343480857 no 2884 0.120434779395573 4321 6252086 SGTC_857 0438-0306 1.35 µM -1.17369926485187 0.14676087477955 no 2885 0.120257752413945 4325 4686136 SGTC_1774 st048371 48.465 µM -1.17386781444863 0.146726258914913 no 2886 0.120223987992857 4243 4242727 SGTC_1423 4048-0112 5.59 µM -1.17454690863326 0.146586845485597 no 2887 0.12008801723609 4316 X1423 SGTC_139 0099-0334 718.624 µM -1.17506812972367 0.146479902653585 no 2888 0.119983729953128 4289 97690 SGTC_732 3970-1727 52.7 µM -1.17557198793591 0.146376572090135 no 2889 0.119882977378607 4336 1275699 SGTC_358 0075-0058 9.45 µM -1.17663219309589 0.14615930650907 no 2890 0.119671171299128 4142 1069125 SGTC_321 4534-3890 65.3 µM -1.18069192290799 0.145329358267917 no 2891 0.118862565675262 4270 699746 SGTC_2506 ethyl hematommate 54.16 µM -1.1841851353472 0.144617768101151 no 2892 0.118169892490452 4333 3940691 An allergen. SGTC_1218 1348-1416 30.7 µM -1.18616493168026 0.144215514479519 no 2893 0.117778586100494 4230 6787668 SGTC_2671 danthron 100 µM -1.18896690564156 0.143647501719525 no 2894 0.117226345053999 4269 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.19035820973206 0.143366019972647 no 2895 0.116952815470983 4374 688801 SGTC_1493 4348-0038 111 µM -1.19161256340738 0.143112564815356 no 2896 0.116706598259984 4246 800424 SGTC_1381 2324-0066 62.1 µM -1.19207675019614 0.143018847847881 no 2897 0.116615576221276 4314 10885928 SGTC_47 0149-0135 24.25 µM -1.19350948026491 0.14272984844599 no 2898 0.116334950778238 4287 5239155 SGTC_1132 3456-3614 2.5 µM -1.19396799930871 0.142637442925142 no 2899 0.116245243024427 4322 3125502 SGTC_2390 9097792 176.6 µM -1.19415520100819 0.142599727725574 no 2900 0.116208631738287 4300 4497149 SGTC_1281 0884-0031 11.8 µM -1.19910134429395 0.141605679481711 no 2901 0.115244270731086 4308 1548255 SGTC_1780 st038448 24.544 µM -1.19920824646166 0.141584246837033 no 2902 0.115223490762973 4317 728868 YDL195W SEC31 SGTC_466 geldanamycin 89.2 µM -1.20001582309128 0.141422408104011 no 2903 0.115066597627207 4261 5288382 HSP90 inhibitor. SGTC_1160 4092-0570 10.5 µM -1.20170233748515 0.141084834262205 no 2904 0.114739437596065 4274 4994975 SGTC_2115 tiliquinol 12.7705 µM -1.20174046161998 0.141077209631116 no 2905 0.114732049708472 4263 71208 A bioactive hydroxyquinoline. SGTC_1112 tnp00069 1.16933 µM -1.20220891589416 0.140983543995231 no 2906 0.114641297900898 4292 145826 SGTC_3039 9090270 49.47 µM -1.20691709789379 0.140044503411213 no 2907 0.113732036166201 4298 17173750 SGTC_540 1187-0821 17.3 µM -1.20923996620075 0.139582779540102 no 2908 0.113285333703911 4228 847520 SGTC_977 1348-1378 135 µM -1.20932315045056 0.139566263966459 no 2909 0.113269360084926 4278 X977 SGTC_994 3910-0338 138 µM -1.20946673817332 0.139537758888831 no 2910 0.113241791150944 4359 3479481 SGTC_1866 st057638 64 µM -1.20985874643899 0.139459957452662 no 2911 0.113166549690091 4277 688802 SGTC_561 1550-0330 72.9 µM -1.21072188892066 0.139288754570068 no 2912 0.113001005208015 4236 6812934 SGTC_1547 harmine 94.2 µM -1.2162602996958 0.138193623238895 no 2913 0.111942889863585 4240 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1406 3909-7906 11.9 µM -1.2214182649809 0.137179011746649 no 2914 0.110963847549742 4325 X1406 SGTC_1574 spiramycin 23.7 µM -1.22308266415849 0.13685270027541 no 2915 0.110649237823071 4265 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1031 k035-0009 16 µM -1.22495648116466 0.136485967031605 no 2916 0.11029580890249 4355 5180959 SGTC_874 0599-0792 117 µM -1.22686542629978 0.13611305049273 no 2917 0.109936587545017 4319 765305 SGTC_1137 ixabepilone 100 µM -1.22897148390043 0.135702437426579 no 2918 0.109541248895751 4267 154225 A novel microtubule stabilizer. SGTC_381 3461-2219 42.7 µM -1.23006881956889 0.135488829043068 no 2919 0.109335667510292 4303 2883159 SGTC_1219 1469-0211 33.1 µM -1.23147299921988 0.135215826339652 no 2920 0.109073004593128 4323 6822282 SGTC_1105 epirubicin 18.1 µM -1.23160762476011 0.135189672067295 no 2921 0.109047845664579 4335 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1152 3909-8331 15.9 µM -1.2317115638194 0.135169481760056 no 2922 0.109028424303478 4274 16001939 SGTC_562 3772-2733 112 µM -1.23589079521162 0.134359372747297 no 2923 0.108249579498417 4302 2876874 YIL048W NEO1 SGTC_2740 felodipine 17.08 µM -1.23682836810892 0.134178090911039 no 2924 0.10807540398467 4358 3333 L-type calcium channel blocker SGTC_3166 9102297 49.47 µM -1.23979521456418 0.133605551784153 no 2925 0.107525574344963 4318 25237072 SGTC_1215 3852-0577 11.2 µM -1.24046111063241 0.133477278990038 no 2926 0.107402444905972 4355 2884876 SGTC_2464 5717415 7.67 µM -1.24071043696406 0.133429272598509 no 2927 0.107356368660048 4288 5285744 SGTC_976 1348-1067 47.6 µM -1.24415137510099 0.132767952069502 no 2928 0.106721927921412 4334 5310671 YGL099W LSG1 SGTC_2689 tacrolimus 100 µM -1.24516079091469 0.132574379460223 no 2929 0.106536326004618 4338 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3028 9087778 49.47 µM -1.24551155728792 0.132507159600933 no 2930 0.106471884959615 4294 17217395 SGTC_1837 st055472 66.5 µM -1.24594383083837 0.132424352248634 no 2931 0.106392508540656 4383 676091 SGTC_313 3474-0040 5.03 µM -1.24869400131109 0.131898358231216 no 2932 0.105888507878652 4336 1043375 YIL048W NEO1 SGTC_941 3237-0776 460 µM -1.24988907083051 0.131670240584344 no 2933 0.105670036182946 4363 760008 SGTC_294 k038-0071 157 µM -1.25461881862055 0.130770087141643 no 2934 0.104808584315269 4342 24152826 SGTC_716 1683-5115 658 µM -1.25543816806779 0.130614583956487 no 2935 0.104659870479842 4321 723597 SGTC_619 1652-1634 108 µM -1.2566952963976 0.130376243984065 no 2936 0.104431995992687 4305 5400454 SGTC_2829 7992743 58.44 µM -1.25718140071712 0.130284163778885 no 2937 0.104343978311528 4333 16462845 SGTC_3111 9122088 49.47 µM -1.25996195824002 0.129758322060708 no 2938 0.103841542922248 4216 16876704 SGTC_807 1315-0151 48 µM -1.26020450417582 0.129712523077181 no 2939 0.103797799217462 4354 4011080 SGTC_1244 0416-0015 52.5 µM -1.26227017775285 0.129322923834053 no 2940 0.103425791947745 4294 96201 SGTC_779 1360-0071 233 µM -1.26293190433761 0.129198289657768 no 2941 0.103306826482867 4375 7566 SGTC_672 1441-0018 53.7 µM -1.2656467156922 0.128687834920157 no 2942 0.102819796509495 4338 251141 SGTC_2221 6807166 181.081 µM -1.26919623113562 0.1280225475286 no 2943 0.10218554246973 4304 674925 SGTC_3199 9111318 49.47 µM -1.27259562181726 0.127387641557009 no 2944 0.101580786501542 4267 8548020 SGTC_1208 2323-2347 50.3 µM -1.2735956849036 0.127201276855134 no 2945 0.10140337115315 4346 5412760 SGTC_1885 st057546 99.9 µM -1.27441000552415 0.12704966598882 no 2946 0.101259074101945 4379 702008 SGTC_547 1120-0019 610 nM -1.27778619498691 0.126422426095659 no 2947 0.100662411642369 4307 3676939 SGTC_495 decylubiquinone 155 µM -1.28466693646891 0.125150785996759 no 2948 0.0994543484669544 4358 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_826 1683-5028 118 µM -1.28912019755309 0.12433254897881 no 2949 0.0986781514178498 4392 722377 SGTC_637 1181-0519 7.26 µM -1.2906570565941 0.12405103860112 no 2950 0.0984113108846982 4360 6252091 YGR060W ERG25 SGTC_2485 5633444 17.78 µM -1.29284119206449 0.123651732745022 no 2951 0.0980329951730199 4358 5724239 SGTC_1282 0886-0010 32.4 µM -1.2929234865647 0.123636705195917 no 2952 0.0980187617437092 4378 2836211 YNL267W PIK1 SGTC_833 3852-0053 558 µM -1.29388563812163 0.123461104496794 no 2953 0.097852463006345 4417 3123681 SGTC_3266 9136860 49.47 µM -1.29519275192729 0.123222825298598 no 2954 0.0976268722748528 4148 4871271 YPR165W RHO1 SGTC_2532 xanthone 78.9 µM -1.29610251288892 0.123057171524237 no 2955 0.0974700846813069 4380 7020 An insecticide. SGTC_1000 4048-0884 8.67 µM -1.29985202909334 0.122376088827238 no 2956 0.0968258445905315 4395 13040088 SGTC_2738 aclarubicin 5.55 µM -1.30079144686276 0.122205863082811 no 2957 0.0966649252143985 4375 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2502 avocadyne acetate 18.59 µM -1.30528372858706 0.121394144497958 no 2958 0.0958981262911844 4314 3952079 SGTC_858 0438-0351 2.77 µM -1.30542974220839 0.121367824790196 no 2959 0.0958732781418017 4350 2799119 SGTC_1671 st016596 74.5 µM -1.30580748671977 0.121299753012835 no 2960 0.0958090167148692 4418 2829167 SGTC_2708 st078559 56 µM -1.30602075518523 0.121261332644127 no 2961 0.0957727497453747 4319 17250902 SGTC_491 tetrandrine 80.3 µM -1.30626630527385 0.121217107332892 no 2962 0.0957310056939133 4374 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2474 5321570 43.32 µM -1.30681759473978 0.121117857520634 no 2963 0.0956373340459915 4356 2841384 SGTC_1560 lithocholic acid 53.1 µM -1.30946975518212 0.1206411824874 no 2964 0.0951876381416628 4306 9903 A bile acid which acts as a detergent. SGTC_2960 9079389 5.97 µM -1.31129890579406 0.120313198250463 no 2965 0.0948783989651289 4359 16457355 SGTC_18 0111-0177 500 nM -1.31322820987491 0.11996793675845 no 2966 0.0945530304628503 4445 721752 SGTC_1750 st081859 2.357 µM -1.31976915549761 0.118802591824618 no 2967 0.0934560513633761 4302 5291695 SGTC_910 3454-3003 490 µM -1.32031940784981 0.118704923903578 no 2968 0.0933641992317992 4286 820824 SGTC_1760 st045453 10.4495 µM -1.32419253930109 0.118019060988481 no 2969 0.0927195540084831 4418 3323419 YIL048W NEO1 SGTC_2597 laccaic acid a 100 µM -1.33070242752508 0.116872599383455 no 2970 0.0916434719858068 4379 5491415 A textile dye. SGTC_925 2064-1272 59.6 µM -1.33268904530234 0.116524311825832 no 2971 0.0913169348474555 4352 6815817 SGTC_669 0108-0021 26.2 µM -1.33677439688064 0.115810395832692 no 2972 0.0906481444552815 4409 17201 SGTC_730 1436-0052 41.2 µM -1.33898706872071 0.115425030326945 no 2973 0.0902874413337259 4430 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_822 1487-0950 154 µM -1.34074774630336 0.115119037202798 no 2974 0.0900011834091075 4396 1958375 SGTC_1979 st071809 45.3 µM -1.3415735860521 0.114975711070818 no 2975 0.0898671476974779 4439 4976333 SGTC_1174 0739-0097 51.1 µM -1.34274502117928 0.114772623931352 no 2976 0.0896772756150533 4433 728447 SGTC_2015 5119600 184 µM -1.34306965207296 0.114716389129999 no 2977 0.0896247106287686 4417 2828786 SGTC_1739 st037196 92.5 µM -1.34775422699394 0.113907076745798 no 2978 0.0888687222359177 4429 612214 SGTC_2803 7707263 71.43 µM -1.3493585099734 0.113630856471995 no 2979 0.0886109202976243 4374 2199229 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.34946904301507 0.113611842848119 no 2980 0.0885931786084091 4358 6708739 YPR165W RHO1 SGTC_770 0389-1121 67.2 µM -1.35200188904886 0.113176770213738 no 2981 0.0881873554876153 4459 6753108 SGTC_666 0272-0154 136 µM -1.35953979482133 0.111889004103616 no 2982 0.0869878006041539 4398 6870312 SGTC_2125 5246583 200 µM -1.36133207618544 0.111584361044067 no 2983 0.0867043853345638 4415 835267 SGTC_1283 0922-0125 16.4 µM -1.36556177072523 0.110867772728689 no 2984 0.0860382762770292 4402 3360884 SGTC_954 1189-0853 2.85 µM -1.36699427303941 0.110625829379581 no 2985 0.0858135502981312 4331 2828194 SGTC_1224 0823-0416 294 µM -1.36725538398917 0.110581769692658 no 2986 0.0857726355031653 4437 3598164 SGTC_1120 ficusin 1.78878 µM -1.36895687963386 0.110294968467604 no 2987 0.0855063770908033 4429 6199 A DNA cross-linker. SGTC_1079 idarubicin 2.36 µM -1.36906315082014 0.110277073291798 no 2988 0.0854897678129757 4428 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_45 0kpi-0036 14.9 µM -1.37156303051679 0.109856714993377 no 2989 0.0850997546068213 4405 2795021 SGTC_943 3253-1379 105 µM -1.37308412417635 0.109601504369455 no 2990 0.0848630979419274 4404 668464 SGTC_1515 3460-0031 42.1 µM -1.37351630585746 0.109529070213295 no 2991 0.0847959478164643 4390 2876596 SGTC_1479 0549-0158 134 µM -1.37842061359223 0.108709510022704 no 2992 0.0840367313104518 4475 5440202 SGTC_2912 7964298 10.93 µM -1.38095650208792 0.108287470917579 no 2993 0.0836461677212083 4424 2975850 SGTC_659 k018-0002 107 µM -1.38271666511975 0.107995227216023 no 2994 0.0833758799724175 4388 6797879 YHR007C ERG11 SGTC_3021 9087658 49.47 µM -1.38338499316081 0.107884412143571 no 2995 0.0832734247531184 4426 25237042 SGTC_1731 st035964 63 µM -1.38816401603534 0.107094391139664 no 2996 0.0825435534373162 4343 6739575 SGTC_2171 5739187 198.077 µM -1.38994754737699 0.106800627013816 no 2997 0.0822724028917301 4378 2262761 SGTC_1339 1486-1321 22.7 µM -1.392042576779 0.106456299456257 no 2998 0.081954752661332 4461 3469382 SGTC_3297 9117502 71.43 µM -1.39460164630497 0.10603679319665 no 2999 0.0815679991860069 4451 7453720 SGTC_2662 daunorubicin 22.37 µM -1.39559511083456 0.105874257615667 no 3000 0.0814182277875006 4324 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_975 1335-0046 28.5 µM -1.40031770233291 0.105104081198332 no 3001 0.0807091010467644 4437 16486740 SGTC_1468 k284-1086 134 µM -1.40087907251568 0.105012801360625 no 3002 0.0806251189108764 4434 15996457 SGTC_918 glabranin 770.725 nM -1.4028567168804 0.104691689877298 no 3003 0.0803297850265415 4448 124049 Also referred to as licorice root. SGTC_1008 4106-0037 6 µM -1.40290550872931 0.104683776510092 no 3004 0.0803225089845859 4457 2905394 SGTC_3133 9127736 49.47 µM -1.41079116972287 0.103410517656365 no 3005 0.0791530994790517 4449 27243420 SGTC_2840 9008771 71.43 µM -1.41270754184192 0.103102795502422 no 3006 0.0788708665687037 4393 2992978 SGTC_2778 tioconazole 65.09 nM -1.41395029670869 0.102903595492101 no 3007 0.0786882482882709 4337 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1067 clotrimazole 1.36 µM -1.41527283663434 0.102691914088895 no 3008 0.0784942580285294 4480 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2517 totarol 10 µM -1.41591515572669 0.102589220855634 no 3009 0.0784001735099761 4446 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2552 juarezic acid 87.02 µM -1.41591712034385 0.102588906869474 no 3010 0.0783998858713607 4388 1549512 SGTC_2199 6590217 200 µM -1.41625780063481 0.102534469727223 no 3011 0.0783500191388077 4376 703109 SGTC_2861 9024595 19.48 µM -1.41761939707574 0.102317110568603 no 3012 0.0781509569679901 4377 16482810 SGTC_2110 5483698 200 µM -1.41781210367706 0.102286374840201 no 3013 0.0781228147371293 4431 2848765 YHR062C RPP1 SGTC_1606 st000094 49.2 µM -1.41815015066138 0.102232474278915 no 3014 0.0780734660518009 4464 1242210 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.41895099836941 0.102104864007998 no 3015 0.0779566512921479 4436 803109 SGTC_2443 5493264 126.67 µM -1.42056711949286 0.10184769780234 no 3016 0.0777213215065084 4477 5340055 SGTC_617 3770-0098 35 µM -1.42074552611972 0.101819337665845 no 3017 0.0776953760984657 4365 5962639 SGTC_2269 7935389 174.42 µM -1.4214879358064 0.101701383377476 no 3018 0.0775874791772817 4443 97605 SGTC_486 niguldipine 82 µM -1.42419332413726 0.101272392264543 no 3019 0.0771952584381075 4523 1236 A calcium channel blocker. SGTC_610 4215-0184 155 µM -1.42460785521328 0.101206777085978 no 3020 0.077135294047372 4464 5605015 SGTC_801 0866-0028 10.1 µM -1.42848682273325 0.100594284895961 no 3021 0.0765758923837885 4484 6849771 SGTC_881 0833-0569 170 µM -1.43323418394713 0.0998483579423085 no 3022 0.0758954618273319 4477 5418700 SGTC_3197 9113331 49.47 µM -1.43352611295312 0.0998026209425417 no 3023 0.0758537709311466 4437 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1738 st035555 74 µM -1.43833174174053 0.0990519134755992 no 3024 0.0751699748676975 4479 5331140 SGTC_1390 3413-2614 145 µM -1.43837086565297 0.0990458187613133 no 3025 0.0751644272528298 4456 3421432 SGTC_1216 1165-0504 9.65 µM -1.44109996965479 0.0986213562093365 no 3026 0.0747782210646361 4483 6304004 SGTC_2859 9028643 45.46 µM -1.44272187912925 0.0983697292966781 no 3027 0.0745494166737643 4294 17151580 SGTC_1534 6-azauridine 81.6 µM -1.44703051766008 0.0977035608997368 no 3028 0.0739441882535471 4488 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3213 9129884 49.47 µM -1.45020135933757 0.0972154268117063 no 3029 0.0735011880615804 4443 17190742 SGTC_650 1328-0195 38 µM -1.4583543689684 0.0959685354408112 no 3030 0.0723714456633304 4475 2780821 SGTC_1073 triclabendazole 3.09 µM -1.45840105027288 0.0959614301953731 no 3031 0.0723650156767758 4505 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1363 1636-0063 10.4 µM -1.46050922342712 0.0956409535079317 no 3032 0.0720750872536872 4471 6072185 SGTC_1820 st053765 18.6 µM -1.46358135772078 0.0951753500313806 no 3033 0.0716541846309573 4491 3690829 SGTC_2083 5306046 65.942 µM -1.46367881510066 0.0951606070469359 no 3034 0.0716408632530624 4461 539837 SGTC_2915 7971052 15.16 µM -1.46424022237526 0.0950757122216505 no 3035 0.0715641618986061 4413 5741558 SGTC_2985 9022375 71.43 µM -1.46481337100389 0.0949890994519848 no 3036 0.0714859214168421 4514 4939335 SGTC_2405 ticlatone 3.52 µM -1.46514832578464 0.0949385088509642 no 3037 0.0714402271622934 4278 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2508 celastrol 40.54 µM -1.46618114333101 0.0947826400484986 no 3038 0.0712994721624472 4402 122724 Celastrol is a natural product and antioxidant. SGTC_1334 1486-0610 236 µM -1.46804279049106 0.0945021639502626 no 3039 0.0710462999810263 4531 3742339 SGTC_3318 9139014 38.6185 µM -1.47103742069367 0.0940522770306648 no 3040 0.0706404985838345 4473 16643984 SGTC_362 0310-0100 9.03 µM -1.47213932497526 0.0938871349602019 no 3041 0.0704916290242695 4502 790235 SGTC_731 3966-0296 387 µM -1.47395019020862 0.093616206131981 no 3042 0.0702475013759806 4477 660956 SGTC_320 4092-0846 5.34 µM -1.4754593421303 0.0933908589043113 no 3043 0.070044545694911 4454 1359356 SGTC_854 0422-0053 192 µM -1.47590027909639 0.0933250937052164 no 3044 0.0699853322896901 4506 3596728 SGTC_2630 antimycin a 100 µM -1.47771374327018 0.0930549774863294 no 3045 0.0697422071332753 4424 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2640 pentamidine 10.38 µM -1.4792695613131 0.092823698678251 no 3046 0.0695341423347916 4445 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.48097500444866 0.0925706661046541 no 3047 0.0693066171614168 4382 4330530 SGTC_3007 9078383 71.4286 µM -1.48610439373527 0.0918127063031354 no 3048 0.0686257551579446 4495 6496995 SGTC_1637 st007924 17.4 µM -1.49215389310597 0.0909247032409505 no 3049 0.0678294031418457 4395 683336 SGTC_2946 9065502 71.43 µM -1.4967968467686 0.0902475000021513 no 3050 0.0672230635165021 4351 16489101 SGTC_2539 epi(13)torulosol 80 µM -1.49772376186677 0.0901127535202415 no 3051 0.0671025177753604 4459 6708597 SGTC_3031 9088762 49.47 µM -1.49980312371939 0.0898110186586885 no 3052 0.0668327039766746 4466 205253 SGTC_1359 1582-0056 520 nM -1.50035293830406 0.0897313611006069 no 3053 0.0667615016471737 4535 3661189 SGTC_2048 5246248 200 µM -1.50043702452242 0.0897191832569827 no 3054 0.0667506174536807 4504 677046 SGTC_2147 5545932 89.7195 µM -1.50164658034641 0.0895441444480663 no 3055 0.0665942033845031 4543 797404 SGTC_1482 3346-2049 8.48 µM -1.50920731440073 0.0884557571600842 no 3056 0.0656229057960416 4538 3826804 SGTC_2858 9025781 8.96 µM -1.50964752206744 0.0883926931087298 no 3057 0.0655666942322569 4344 4894980 YPL153C RAD53 SGTC_2815 7968870 71.43 µM -1.50994396398298 0.088350243787663 no 3058 0.0655288616317752 4425 2977326 YHR190W ERG9 SGTC_2679 rapamycin 1 nM -1.514674363948 0.0876749229789281 no 3059 0.0649274448346388 4370 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2919 7978188 46.38 µM -1.51921358068567 0.0870305239103365 no 3060 0.0643543719954356 4509 2980291 SGTC_535 2293-4129 48.2 µM -1.52221382272082 0.08660654771824 no 3061 0.0639777563645642 4502 396118 YIL048W NEO1 SGTC_884 0851-0618 334 µM -1.52363132579068 0.0864067725288562 no 3062 0.0638004166481324 4522 9642473 SGTC_2973 9094665 17.96 µM -1.52562480716775 0.0861264053862117 no 3063 0.0635516652142161 4496 25237061 YIL048W NEO1 SGTC_2777 climbazole 1.536 µM -1.52974292335585 0.085549381381759 no 3064 0.0630401872442017 4324 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2667 digitoxin 100 µM -1.53441685969673 0.0848979896784885 no 3065 0.0624635662520729 4477 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.53896049296973 0.0842683290839678 no 3066 0.0619069707069877 4510 688751 SGTC_682 0kpi-0099 17 µM -1.53982101468522 0.084149473013408 no 3067 0.0618019940077185 4515 1714895 YML126C ERG13 SGTC_1941 st076221 61.8 µM -1.54229968846384 0.0838078195648404 no 3068 0.0615003923162045 4399 2828568 SGTC_3056 9094900 49.47 µM -1.54618445245241 0.0832744522191772 no 3069 0.0610300136406571 4530 25236784 SGTC_1634 st006576 41 µM -1.54671514033779 0.0832017888057295 no 3070 0.0609659752947536 4496 3915356 SGTC_1170 0310-0127 64.8 µM -1.54691864639987 0.0831739367810779 no 3071 0.0609414320657481 4525 774975 SGTC_2119 5528445 120.635 µM -1.54740791759687 0.0831070033703821 no 3072 0.0608824566130744 4536 791935 SGTC_2523 spermine 47.74 µM -1.54864735269697 0.0829376271220144 no 3073 0.0607332580932538 4514 1103 A DNA binding polyamine. SGTC_922 1866-0035 480 µM -1.54920069066071 0.0828620940632184 no 3074 0.0606667417531694 4454 3156169 SGTC_785 1270-0111 65.3 µM -1.55042587219683 0.0826950355837599 no 3075 0.0605196663715345 4438 6741994 SGTC_3177 9107506 49.47 µM -1.55446182685064 0.0821465094082014 no 3076 0.0600371477003217 4492 8897194 SGTC_166 k072-0058 166.424 µM -1.55503832306727 0.082068382095385 no 3077 0.05996847124895 4399 5846229 SGTC_1374 2889-5571 141 µM -1.55951373173419 0.0814637735641599 no 3078 0.0594374185334981 4512 2853281 SGTC_2825 7998094 58.44 µM -1.56128872632248 0.0812249119660258 no 3079 0.0592278211832468 4501 2987815 SGTC_65 0798-0905 34.986 µM -1.56788544588526 0.080341819312515 no 3080 0.0584539344791958 4519 3602145 SGTC_2587 piperic acid 92.2 µM -1.57064744231918 0.0799742373077773 no 3081 0.0581322817804153 4466 5370536 SGTC_270 tamoxifen 5.46 µM -1.57823662247369 0.0789707747597218 no 3082 0.0572556298673777 4536 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3204 9114183 49.47 µM -1.58064210261087 0.0786547141988455 no 3083 0.056979946694767 4487 17027248 SGTC_2639 lactacystin 53 µM -1.58670790737285 0.0778619742126633 no 3084 0.0562894073025141 4554 3870 A proteasome inhibitor. SGTC_3287 9117173 37.0625 µM -1.58675924508055 0.0778552908608368 no 3085 0.0562835912296346 4562 2789709 SGTC_2237 6667747 47.222 µM -1.58799473547604 0.0776945809756169 no 3086 0.0561437647866715 4532 729940 YDL015C TSC13 SGTC_2363 9053361 176 µM -1.58801184493757 0.0776923571835536 no 3087 0.0561418303505799 4565 6469797 YMR079W SEC14 SGTC_1340 1486-1359 257 µM -1.59012879877132 0.0774175800551333 no 3088 0.0559028878424611 4495 4309068 SGTC_3294 9122953 26.2835 µM -1.59449785456081 0.0768528182295262 no 3089 0.0554122854437453 4528 16459826 SGTC_184 1494-0393 24.714 µM -1.60186833740096 0.0759071864546687 no 3090 0.0545923637191802 4528 3090647 SGTC_737 1950-0117 57.9 µM -1.6057412319664 0.0754138590059329 no 3091 0.054165388912024 4552 5393513 SGTC_2645 abamectin 100 µM -1.60898408585925 0.075002668658761 no 3092 0.0538099107372692 4501 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2065 5221596 34.26 µM -1.61040739625946 0.0748227353284273 no 3093 0.0536544734866987 4520 788581 SGTC_945 3381-0768 11.3 µM -1.61304132713014 0.0744906255997536 no 3094 0.0533677647469009 4557 1126236 YIL048W NEO1 SGTC_3251 9135047 49.47 µM -1.61457236076682 0.0742980969244381 no 3095 0.0532016674529961 4594 17682963 SGTC_1687 st020778 55.3625 µM -1.62074380160602 0.0735258847160851 no 3096 0.0525362977624743 4579 4259299 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.62110831979861 0.0734804664236337 no 3097 0.0524972050022268 4563 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1815 st051655 58.2 µM -1.62253687928794 0.0733026773375389 no 3098 0.0523442216359023 4515 5984156 SGTC_2473 5854593 8.94 µM -1.62318017501997 0.07322272453086 no 3099 0.0522754472663954 4517 2872951 SGTC_1038 k292-0204 154 µM -1.62337648321724 0.0731983394147593 no 3100 0.052254474367787 4505 4454212 SGTC_2744 captopril 92.04 µM -1.62988990568063 0.0723927699987651 no 3101 0.0515623837326057 4617 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2986 9022445 71.43 µM -1.63453185668001 0.0718228190690823 no 3102 0.0510736113961726 4527 6459286 SGTC_1012 4112-3522 18 µM -1.63881039678918 0.0713005424279732 no 3103 0.0506263766155276 4559 3112398 SGTC_2431 5490079 200 µM -1.64063798418 0.0710783415138577 no 3104 0.0504362926303526 4582 5722345 SGTC_402 epigallocatechin gallate 10 µM -1.6431402302533 0.0707749775074947 no 3105 0.0501769614260521 4534 65064 An antioxidant. SGTC_2783 7738165 71.43 µM -1.64453916191239 0.0706058097846098 no 3106 0.0500324409419455 4545 17201110 SGTC_2837 9008476 45.46 µM -1.64522928390663 0.0705224703932849 no 3107 0.0499612683476692 4522 2992805 SGTC_2358 9037157 4 µM -1.64548097733087 0.0704920946257141 no 3108 0.0499353311927192 4551 2388925 SGTC_1693 xanthone 101.9 µM -1.64883934424798 0.0700877499829154 no 3109 0.049590276107201 4625 7020 An insecticide. SGTC_3142 9086498 49.47 µM -1.64888178476012 0.0700826516201895 no 3110 0.0495859277667476 4425 25236367 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.65394206343244 0.0694768048381817 no 3111 0.0490696424911574 4587 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_835 0312-0010 67.2 µM -1.65448469159034 0.0694120783337901 no 3112 0.0490145355968317 4599 1626196 SGTC_2549 cedrol 20.94 µM -1.65633076889229 0.0691922197916521 no 3113 0.048827426355072 4524 6708665 A sedative which affects the nervous system. SGTC_2309 7664088 163.95 µM -1.65950795941371 0.0688150892257905 no 3114 0.0485067390583785 4537 704922 SGTC_2223 6903751 107.57 µM -1.66240409177605 0.0684727026376274 no 3115 0.0482158895210305 4546 5598863 SGTC_2067 5224629 34.075 µM -1.66525627526542 0.0681367976943162 no 3116 0.0479308189569361 4544 2835000 SGTC_1618 st003135 44.5 µM -1.66937785044099 0.0676536439913714 no 3117 0.0475212602211027 4555 1270615 SGTC_39 0986-0283 58.349 µM -1.67019041639725 0.0675587036516455 no 3118 0.0474408477660546 4585 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3261 9137475 49.47 µM -1.67126642361869 0.0674331412565395 no 3119 0.0473345326711022 4605 17027690 SGTC_1223 0764-0573 147 µM -1.67253337882626 0.0672855278880231 no 3120 0.0472095957756359 4572 1609797 SGTC_2675 theaflavin digallate 100 µM -1.67300547954181 0.0672305872067208 no 3121 0.0471631086667859 4513 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_843 0310-0051 143 µM -1.67544058086222 0.0669477531640972 no 3122 0.0469239100643227 4594 2065037 SGTC_1506 4226-2149 212 µM -1.67683915436931 0.0667857271773448 no 3123 0.0467869694637971 4575 991114 SGTC_3017 9080681 49.47 µM -1.68244845385728 0.066138932117369 no 3124 0.0462409561704033 4604 16451914 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.68550889796858 0.0657880912601093 no 3125 0.0459452147740194 4545 6708630 An antioxidant. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.68612472516238 0.0657176691874677 no 3126 0.0458858893037398 4533 4000243 SGTC_1874 staurosporine 7.6 µM -1.69419902160991 0.0647997411942177 no 3127 0.0451137353530415 4579 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_628 1636-0253 16 µM -1.69525460961083 0.0646804759238488 no 3128 0.0450135656977449 4580 4456143 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.69905835553971 0.0642521244677597 no 3129 0.0446540944598484 4638 368090 SGTC_286 k060-0067 22.9 µM -1.70608130998815 0.0634670452626232 no 3130 0.0439964709321621 4629 5985051 SGTC_3164 9100705 49.47 µM -1.70700895819289 0.0633639063149756 no 3131 0.0439101936811987 4609 17174235 SGTC_1803 st050068 52.4 µM -1.7099587598213 0.0630368047147347 no 3132 0.043636749689667 4609 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1844 rapamycin 4 nM -1.71128769959942 0.0628898698541491 no 3133 0.0435140079542853 4439 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_20 0481-0013 4.944 µM -1.7146025647969 0.0625245231051457 no 3134 0.0432090590984461 4649 182045 SGTC_836 0330-0104 1.35 µM -1.71520438449568 0.0624583715746406 no 3135 0.0431538806511684 4628 46494820 SGTC_2791 5663188 71.43 µM -1.72174942323196 0.0617424654082924 no 3136 0.042557460055742 4596 54690634 SGTC_1851 st056236 18.9 µM -1.72528167507732 0.0613587728171653 no 3137 0.0422383613650388 4574 5393171 SGTC_1604 st002052 72.4 µM -1.72750382197604 0.0611183471931505 no 3138 0.0420386096856171 4630 6254834 YHR062C RPP1 SGTC_510 ag-490 170 µM -1.73990050137655 0.0597905715994481 no 3139 0.0409382453231927 4718 5328779 SGTC_2614 arthonioic acid 13.39 µM -1.74546077719656 0.0592024145975262 no 3140 0.0404523471025532 4474 6710684 SGTC_1519 esterone 74 µM -1.74669706916033 0.0590722602466839 no 3141 0.0403449495255796 4605 698 A steroid. SGTC_396 dithiazanine 1.25 µM -1.74848233083933 0.0588847076658331 no 3142 0.0401902712772577 4569 10578 An antihelmenthic. SGTC_1343 1487-0095 224 µM -1.7489906041478 0.05883139600826 no 3143 0.0401463217800359 4594 4560101 YGL055W OLE1 SGTC_2036 5160441 105 µM -1.75239753543766 0.0584750278000374 no 3144 0.0398527374708248 4583 134534 YIL048W NEO1 SGTC_3153 9100258 49.47 µM -1.75684546945833 0.0580123234682409 no 3145 0.0394720762199761 4523 25236848 SGTC_3236 9132701 49.47 µM -1.75992449704018 0.057693710947676 no 3146 0.0392103045789872 4624 24282524 SGTC_2196 6573537 42.6665 µM -1.76140495704115 0.0575410061331681 no 3147 0.0390849433191216 4643 2903087 SGTC_105 0111-0055 734.78 µM -1.76268221134169 0.0574095169648032 no 3148 0.0389770513124303 4613 5179370 SGTC_2475 5812728 15.03 µM -1.76578805965009 0.0570907662933558 no 3149 0.0387157062340409 4576 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2097 5376186 200 µM -1.76603439986026 0.0570655443495684 no 3150 0.0386950389124625 4593 742755 SGTC_1673 st016611 27.3 µM -1.76604187787647 0.0570647788379016 no 3151 0.0386944116663824 4603 5226799 SGTC_1211 1056-0033 32.3 µM -1.77189146855485 0.0564684387195848 no 3152 0.0382062874450723 4643 6741922 SGTC_82 0054-0107 293.755 µM -1.77462284572489 0.0561916740398824 no 3153 0.0379800912189806 4601 3104697 SGTC_1936 st074407 74.3 µM -1.77820561860919 0.0558302621264872 no 3154 0.0376850452456847 4630 809813 SGTC_804 1595-0054 20.9 µM -1.77860611213606 0.0557899765997502 no 3155 0.0376521806692365 4615 761523 Stimulates phospholipase C. SGTC_768 0384-0033 77.3 µM -1.78015991780044 0.0556338968232268 no 3156 0.0375248964928928 4586 3965305 YMR134W ERG29 SGTC_2322 7413319 38.22 µM -1.78254859065361 0.05539462702375 no 3157 0.0373299073863611 4551 1840400 SGTC_1683 st010134 710 nM -1.78945463116857 0.0547074280058642 no 3158 0.0367708139066308 4587 3818134 SGTC_2862 9027634 71.43 µM -1.78992931668795 0.0546604421612277 no 3159 0.0367326375904908 4584 5012562 SGTC_997 3996-0078 137 µM -1.7951905831784 0.0541417997417693 no 3160 0.036311670152242 4658 735687 SGTC_2796 7949634 45.45 µM -1.80049104586008 0.0536232394580571 no 3161 0.0358915680942945 4592 2971588 SGTC_2161 5662504 8.5105 µM -1.80109577845976 0.0535643275292244 no 3162 0.0358438925093583 4622 2859334 SGTC_2524 avocatin b 10.57 µM -1.80473809421157 0.0532105836229564 no 3163 0.0355578378454677 4654 6710748 SGTC_511 blebbistatin 171 µM -1.80522284695206 0.0531636441076001 no 3164 0.0355199085725359 4659 3476986 A myosin inhibitor. SGTC_429 1112-0049 25.5 µM -1.81090505833739 0.0526158693741316 no 3165 0.0350777747264862 4595 2836170 SGTC_1139 k015-0024 46.9 µM -1.81365743790585 0.0523521504859014 no 3166 0.0348652407976275 4644 2766652 SGTC_3265 9137266 49.47 µM -1.81380730205957 0.0523378214539493 no 3167 0.0348536989638365 4617 17224265 SGTC_1875 nocodazole 6 µM -1.81431508068362 0.0522892941265866 no 3168 0.0348146155545678 4651 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2681 menadione 3.18 µM -1.8150441939913 0.0522196768042705 no 3169 0.034758559084689 4652 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2145 5634607 200 µM -1.81760711587074 0.0519755474403108 no 3170 0.0345621016285995 4640 308662 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.8183652087179 0.051903509873146 no 3171 0.0345041661156297 4612 229346 A bile salt which induces apoptosis. SGTC_217 ketoconazole 989 nM -1.8184572938282 0.0518947649171264 no 3172 0.0344971341590228 4440 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.81870519536965 0.0518712285141371 no 3173 0.0344782093395886 4620 6312947 SGTC_3117 9124945 49.47 µM -1.82128648465534 0.0516266580728657 no 3174 0.0342816599087356 4561 17592065 SGTC_360 0957-0399 1.01 µM -1.83962007497699 0.0499158774170182 no 3175 0.0329120174938242 4648 6752301 YPR165W RHO1 SGTC_1358 1509-0022 2.48 µM -1.84372847801562 0.0495387766475824 no 3176 0.0326113602907761 4658 3258434 SGTC_1664 st014217 9.02 µM -1.84406768231165 0.0495077437601131 no 3177 0.0325866385269477 4698 3982782 SGTC_394 menadione 8.33 µM -1.84526959171482 0.0493979091805268 no 3178 0.0324991657904662 4643 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1450 4112-4260 37.6 µM -1.84828274652263 0.0491234118425814 no 3179 0.0322807251766971 4638 1633175 SGTC_2188 6126565 140.678 µM -1.86582969451716 0.0475490135100368 no 3180 0.0310325982010967 4580 874518 SGTC_513 4245-1575 41.7 µM -1.86963858583317 0.0472126582791828 no 3181 0.0307670115931545 4472 719745 SGTC_2625 euphol 100 µM -1.87006195146698 0.0471753898122617 no 3182 0.0307376076831143 4644 6708538 A triterpene alcohol. SGTC_2819 7996655 46.38 µM -1.87066949623395 0.0471219494412957 no 3183 0.0306954526790525 4624 6456960 SGTC_3176 9106582 49.47 µM -1.87351657291724 0.0468721634322477 no 3184 0.0304985431914455 4679 17018027 SGTC_97 0535-0701 19.132 µM -1.87556858168096 0.0466927914848717 no 3185 0.0303572719913555 4565 2832013 YGL099W LSG1 SGTC_3129 9127257 49.47 µM -1.87990842595508 0.0463152474371851 no 3186 0.0300602796803574 4603 837894 SGTC_3059 1327-0034 3 µM -1.88113122065769 0.0462093143573697 no 3187 0.029977035478447 4518 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1475 4092-1048 11.7 µM -1.88396295587257 0.045964742622654 no 3188 0.0297849932092472 4657 2881759 SGTC_1304 1165-0502 251 µM -1.90032691292559 0.0445717191485909 no 3189 0.0286951158189039 4656 767425 SGTC_588 3970-1144 52.9 µM -1.9033371032614 0.0443192108415808 no 3190 0.0284982861850986 4588 1888707 SGTC_2469 5655019 90.81 µM -1.90768028788589 0.0439569180353461 no 3191 0.0282162754937943 4697 2788239 SGTC_919 tnp00227 403.569 nM -1.91298322115825 0.0435178090458106 no 3192 0.0278751002492222 4618 1269246 A methoxyflavone. YNL221C POP1 SGTC_2918 7977171 22.06 µM -1.91606920217458 0.0432639086931907 no 3193 0.0276781439055969 4648 2236483 SGTC_729 4092-0585 94.1 µM -1.93526017381482 0.041711699045351 no 3194 0.0264791884546009 4683 2169061 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.94101897455663 0.041254814031541 no 3195 0.0261279879499908 4631 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_470 aa-861 153 µM -1.94471777437727 0.0409635085901299 no 3196 0.0259044775463977 4630 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2687 chenodiol 100 µM -1.94753610854523 0.0407426675579699 no 3197 0.0257352475657646 4686 5702181 A cholesterol synthesis inhibitor. SGTC_1082 camptothecin 424.86 nM -1.94935895210479 0.0406003470973501 no 3198 0.0256262864676053 4557 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3319 9138450 16.7555 µM -1.95100715223873 0.0404720097460022 no 3199 0.0255280974905416 4638 2029690 SGTC_1754 st042065 16.137 µM -1.96077198621132 0.0397184103084515 no 3200 0.0249528136643373 4447 1126236 YIL048W NEO1 SGTC_256 clotrimazole 625 nM -1.9627110231235 0.0395701316987136 no 3201 0.0248398807753811 4625 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1668 st014914 51.6 µM -1.96501051035175 0.039394873233961 no 3202 0.0247065105416085 4696 2839556 SGTC_435 c-PAF 6.7 µM -1.96911084721408 0.0390839280045111 no 3203 0.0244701817475245 4593 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_488 nitrendipine 139 µM -1.96963231907475 0.0390445262737242 no 3204 0.0244402624223745 4692 4507 Dihydropyridine L-type calcium channel blocker. SGTC_886 0866-0150 153 µM -1.97179984063618 0.0388810976197463 no 3205 0.0243162302788718 4697 271463 SGTC_1076 itraconazole 331 nM -1.97569345813779 0.0385889227547287 no 3206 0.024094753149352 4673 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3249 9135183 49.47 µM -1.97924930101726 0.0383236597096203 no 3207 0.0238939723258851 4642 4902779 SGTC_1697 st025554 27.742 µM -1.99433628617386 0.0372146702228435 no 3208 0.0230576581443856 4706 1269519 SGTC_1861 st057647 17.4 µM -1.99437841100814 0.0372116108865623 no 3209 0.0230553580082633 4684 688668 SGTC_2795 7780010 54.55 µM -1.99486074866986 0.0371765955282876 no 3210 0.0230290347663125 4643 953673 SGTC_1711 st032263 62.8 µM -1.99521438361239 0.037150940468774 no 3211 0.023009751471209 4682 3958979 SGTC_280 3448-3607 3.04 µM -1.99652272168518 0.0370561505664966 no 3212 0.0229385275307777 4660 626179 SGTC_3002 9075603 71.4286 µM -2.00040999938034 0.0367756805362269 no 3213 0.0227280047593584 4641 20105405 SGTC_1362 1611-0397 101 µM -2.00249072334585 0.0366262695011219 no 3214 0.022615989914376 4695 27816 SGTC_2966 9084041 48.03 µM -2.00538062343925 0.036419577919029 no 3215 0.0224611857851445 4640 17741380 SGTC_2401 5128683 200 µM -2.00652391713726 0.0363380711726995 no 3216 0.022400189805132 4652 708373 SGTC_763 3453-1109 128 µM -2.0161935141777 0.0356546694226967 no 3217 0.0218898721899178 4704 1560353 SGTC_3181 9108277 49.47 µM -2.01760192575458 0.0355560141414754 no 3218 0.0218163680800608 4690 17097298 SGTC_1877 wortmannin 25 µM -2.02183363847825 0.0352609401030189 no 3219 0.0215967706747678 4684 312145 A covalent inhibitor of PI 3-kinase. SGTC_3219 9131112 49.47 µM -2.02552941028643 0.0350048828001931 no 3220 0.0214065158297609 4571 17612988 YMR079W SEC14 SGTC_3283 9109332 35.8195 µM -2.02878707229167 0.0347804467110523 no 3221 0.0212399913016008 4543 17027281 SGTC_346 4513-0042 7.16 µM -2.04332975055822 0.0337928969094237 no 3222 0.0205099032163427 4657 2827372 SGTC_3016 9080866 49.47 µM -2.04993275165234 0.0333521839249598 no 3223 0.0201854968145115 4687 17066299 SGTC_2707 st078556 66.6 µM -2.05267722171531 0.0331704037901745 no 3224 0.0200519463150719 4637 17250899 SGTC_367 0335-0881 7.1 µM -2.056599578859 0.0329120237276047 no 3225 0.0198623793920087 4626 23828853 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.05670872250966 0.032904857824216 no 3226 0.0198571263190479 4663 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.06409740583888 0.0324227305995265 no 3227 0.0195042409452365 4698 689007 SGTC_542 3381-0244 89.3 µM -2.06723409291221 0.0322198249222559 no 3228 0.019356050570678 4700 1112843 SGTC_1088 bifonazole 369 nM -2.07937227976918 0.0314444828988153 no 3229 0.0187915731602036 4709 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2114 5491910 81.25 µM -2.08116611393693 0.0313312185566159 no 3230 0.018709352011831 4710 2849228 SGTC_2914 7968218 45.32 µM -2.08891045252082 0.0308460994650485 no 3231 0.0183578923795426 4687 2977111 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.09889076843377 0.0302301008244106 no 3232 0.01791326541304 4685 442882 SGTC_2741 miltefosine 3.04 µM -2.10048203203234 0.0301328347228635 no 3233 0.0178432297886503 4744 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_577 r071-0003 38.6 µM -2.104494110346 0.0298887473890559 no 3234 0.0176676839171387 4681 4568517 YMR134W ERG29 SGTC_251 melphalan 456.522 µM -2.11504139272267 0.0292548833451068 no 3235 0.0172132097874085 4733 460612 A DNA alkylator. SGTC_4 0960-0234 25.671 µM -2.11560548952671 0.0292212995573352 no 3236 0.0171891872906145 4658 6821112 SGTC_1616 st002734 56.1 µM -2.11610506016143 0.0291915841117617 no 3237 0.0171679366141209 4697 4026101 SGTC_2781 5567276 71.43 µM -2.12663874048893 0.0285708418944889 no 3238 0.0167250555161303 4681 2853274 SGTC_255 tunicamycin 200.472 nM -2.12790652288564 0.0284968781079513 no 3239 0.0166724173321821 4656 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_500 h-89 112 µM -2.1306187805677 0.0283391769282978 no 3240 0.0165602805394206 4685 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_266 formosanin C 406 nM -2.13355108367687 0.028169499194646 no 3241 0.016439772906391 4588 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_309 k408-0051 1.48 µM -2.13604272373351 0.0280259858894538 no 3242 0.0163379658002203 4639 3640463 SGTC_2219 9098279 200 µM -2.14457038500914 0.02753941072899 no 3243 0.0159936061278997 4691 902349 SGTC_2175 5807670 165.306 µM -2.14488704222774 0.027521479225572 no 3244 0.015980939754555 4696 241186 SGTC_1325 1431-0015 227 µM -2.15350005456082 0.0270374665338094 no 3245 0.0156396999055249 4713 1103340 SGTC_1835 st008666 49.2 µM -2.16629973042349 0.0263313205158536 no 3246 0.0151441451567661 4701 690455 SGTC_913 3487-1245 167 µM -2.1835276813058 0.0254052684885804 no 3247 0.0144984863651722 4671 4016153 SGTC_1310 1188-0297 994 nM -2.18766960472211 0.0251867422694455 no 3248 0.0143468388263614 4646 1588352 SGTC_308 4092-1169 104 µM -2.18972031417158 0.0250791320234782 no 3249 0.0142722634480426 4694 2268590 YDL196W YDL196W SGTC_902 1120-0002 2.07 µM -2.21617268460937 0.0237252619598109 no 3250 0.0133398389250095 4715 3280475 SGTC_740 k014-0057 261 µM -2.21872880620032 0.0235977550021918 no 3251 0.0132525900197187 4721 4012779 SGTC_340 k038-0059 454 µM -2.22291173499673 0.0233903415313861 no 3252 0.0131108761609635 4732 23733424 SGTC_575 k072-0246 11.9 µM -2.22417714294028 0.0233278984387418 no 3253 0.0130682641300972 4774 6796779 SGTC_3246 9135460 32.98 µM -2.22458665109533 0.0233077208324706 no 3254 0.0130544997940822 4740 41446951 SGTC_2999 9069765 71.4286 µM -2.22888119838548 0.0230969998960594 no 3255 0.0129109052089687 4679 2097066 SGTC_2600 tangeritin 87.95 µM -2.23466639314666 0.0228156752277203 no 3256 0.0127196292520376 4683 68077 A bioactive flavone. SGTC_789 1309-1135 70.6 µM -2.24003171971657 0.0225573540622477 no 3257 0.0125444318420987 4719 3092424 SGTC_2027 5150920 200 µM -2.2438889539009 0.022373169500392 no 3258 0.0124197735214276 4715 786715 SGTC_505 gw-5074 63.9 µM -2.24860988006516 0.0221494712007739 no 3259 0.0122686636371492 4710 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2666 tannic acid 100 µM -2.25076261539975 0.0220480934298224 no 3260 0.012200288264863 4715 16134267 A thiamine antagonist. SGTC_2335 9018011 154.17 µM -2.25734081495665 0.0217407333209256 no 3261 0.0119933934299156 4720 6458208 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.27191649956095 0.0210725747984503 no 3262 0.0115457770745036 4750 4174840 SGTC_249 wiskostatin 11.211 µM -2.28420126842927 0.0205230047602395 no 3263 0.0111798525327313 4729 2775510 A n-wasp and actin depolymerizer. SGTC_2742 clothiapine 36.27 µM -2.29046388414159 0.0202475460809283 no 3264 0.0109972199395105 4750 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2616 abietic acid 100 µM -2.29493170632403 0.0200529520028691 no 3265 0.0108685192105977 4735 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_374 0880-0231 82.3 µM -2.33281250594 0.0184659184313953 no 3266 0.00982899400801212 4646 6833587 SGTC_2620 irigenin 100 µM -2.35581760918375 0.0175553135879801 no 3267 0.00924099491405112 4714 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_407 eburnamonine 100 µM -2.37506797689341 0.0168230583548324 no 3268 0.00877285928620658 4671 3195 SGTC_3240 9133527 49.47 µM -2.37559445602212 0.0168034045070289 no 3269 0.00876035371782458 4757 17617455 SGTC_1324 1418-0026 34.4 µM -2.37753645670108 0.0167310779497625 no 3270 0.00871436001410397 4762 1372513 SGTC_302 1094-0063 18.9 µM -2.384831584439 0.0164617576735726 no 3271 0.00854347086019377 4758 5440289 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.39569683650927 0.0160675203052981 no 3272 0.00829440228876632 4751 688667 SGTC_2046 4110841 106 µM -2.39830661672581 0.0159740407392829 no 3273 0.00823553559479175 4756 44119630 YMR134W ERG29 SGTC_1061 3448-9325 110 µM -2.39932805630986 0.0159375810044132 no 3274 0.00821259592689296 4729 723482 SGTC_2969 9091408 28.7 µM -2.42551981428618 0.0150267522050126 no 3275 0.00764324063008188 4703 4286311 SGTC_1422 4031-0024 15.5 µM -2.43144759855649 0.0148269346987834 no 3276 0.00751931174969676 4747 782427 SGTC_2717 st081029 62.2815 µM -2.4641607141433 0.0137648371899104 no 3277 0.00686672583926573 4756 5292846 SGTC_660 4031-1742 102 µM -2.50463998305267 0.0125419829489676 no 3278 0.00612880449733489 4685 6738706 SGTC_1462 k081-0014 26.5 µM -2.50933270520753 0.0124064939613048 no 3279 0.00604797482247929 4287 3270634 SGTC_2084 5306078 60.6385 µM -2.52192201072465 0.0120492584258969 no 3280 0.00583577908989081 4747 679340 SGTC_2330 7979373 200 µM -2.5343324403391 0.0117058627918085 no 3281 0.00563308965559947 4726 1863007 SGTC_955 1216-0110 33 µM -2.5441176669044 0.0114411268922859 no 3282 0.0054777086349727 4740 3619719 SGTC_2581 avocatin a 64 µM -2.54673059049635 0.0113713210969862 no 3283 0.00543686724400863 4710 6710728 A skin care supplement. SGTC_683 panaxydol 45 µM -2.55387736226356 0.0111822780898107 no 3284 0.00532653855116303 4759 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1600 coumarin 106 71.1 µM -2.55566021955734 0.0111355468262543 no 3285 0.00529932777740862 4773 100336 A hepatotoxic, DNA x-linker. SGTC_2711 st079103 59.1 µM -2.56125907398303 0.010989895087469 no 3286 0.00521467752273788 4764 54693780 SGTC_2096 5468907 200 µM -2.56318010823773 0.0109403035517368 no 3287 0.00518591144892162 4767 759785 SGTC_1712 st032288 53.4 µM -2.56662311740431 0.0108519093082464 no 3288 0.00513470808629045 4631 2883011 SGTC_951 1171-0579 82.7 µM -2.57597171628097 0.010615026073263 no 3289 0.00499794112614976 4728 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2716 st080858 38.6235 µM -2.58122124955871 0.0104839934660923 no 3290 0.00492257314778978 4763 5296050 SGTC_2586 curcumin 80 µM -2.59008680009319 0.0102659010560943 no 3291 0.00479758673457776 4700 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1005 4092-0690 4.4 µM -2.59375669430303 0.0101767860560817 no 3292 0.0047466821179815 4763 1529343 SGTC_1261 0712-0010 12.7 µM -2.6120047300764 0.00974362336737092 no 3293 0.00450065043672738 4762 2840123 SGTC_612 0302-0167 22.4 µM -2.62944658383173 0.00934474146544699 no 3294 0.00427619833052655 4760 235821 SGTC_1050 3232-1156 69.3 µM -2.63727264862514 0.00917045800869647 no 3295 0.00417878137670532 4757 700529 SGTC_1818 st052136 56.3 µM -2.64061486599816 0.00909689943892657 no 3296 0.00413778671256326 4585 674169 SGTC_2896 9052656 71.43 µM -2.65722144608282 0.0087390169046959 no 3297 0.00393938353913058 4464 6469436 SGTC_2619 obliquin 87.91 µM -2.69483557300167 0.00797372100755392 no 3298 0.00352116868742775 4771 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2411 st077133 39.94 µM -2.70690232436469 0.00774102100543172 no 3299 0.00339571179099171 4741 1403142 YNL221C POP1 SGTC_649 1123-0311 367 µM -2.73029628411305 0.00730685268835348 no 3300 0.0031638713831347 4730 693629 YIL048W NEO1 SGTC_1072 oxiconazole 14.9 nM -2.76759543771082 0.00665894449371118 no 3301 0.0028235754170127 4759 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1644 st010134 20.9 µM -2.78553113912016 0.00636587846272538 no 3302 0.00267200534438615 4788 3818134 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.79527416293977 0.00621151300992861 no 3303 0.00259278591152475 4777 2374 Ca(2+)-ATPase inhibitor. SGTC_1161 k007-0610 110 µM -2.80127118592951 0.00611815477327799 no 3304 0.00254508620818689 4742 5843850 SGTC_2345 9052315 157.45 µM -2.80702187792684 0.00602980114523071 no 3305 0.00250009228179865 4772 6469265 SGTC_2004 4023728 41.89 µM -2.80988909712163 0.00598617316349672 no 3306 0.00247792869671221 4763 360084 YDR527W RBA50 SGTC_1800 st050079 29.0735 µM -2.81630860887245 0.00588950630784584 no 3307 0.00242894889015808 4709 3645560 SGTC_445 e6 berbamine 66 µM -2.81852206164823 0.00585649793197442 no 3308 0.00241226477272935 4787 6610268 A calcium/calmodulin antagonist. SGTC_1045 1348-1485 165 µM -2.83249731805877 0.00565185360575112 no 3309 0.00230929768114235 4767 6810614 SGTC_2024 5144227 134 µM -2.84781611590681 0.00543485214531319 no 3310 0.00220101757538215 4766 3475211 SGTC_268 camptothecin 39.6153 µM -2.87686035051775 0.00504366007489708 no 3311 0.00200826652464368 4757 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1845 st056753 3.01 µM -2.87816624687438 0.00502667563015672 no 3312 0.00199997141999613 4778 5375839 SGTC_1656 st012921 11 µM -2.8782604908717 0.0050254518687557 no 3313 0.00199937398362547 4760 6732821 SGTC_1901 st060216 58.6 µM -2.88082002807088 0.00499231748908118 no 3314 0.00198321026493166 4781 688792 SGTC_2476 5806916 10.51 µM -2.91468988267854 0.00457182503917585 no 3315 0.00178021071777866 4771 2870194 SGTC_670 4204-0025 119 µM -2.95562038455949 0.0041060547550871 no 3316 0.00156020447216605 4789 719039 SGTC_1707 st032323 6.317 µM -2.96911103877255 0.0039621169372781 no 3317 0.00149331326211065 4692 3132057 YMR211W DML1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.96913427542216 0.00396187296384284 no 3318 0.0014932003394883 4792 16623 A steroid. SGTC_451 chloral hydrate 100 µM -2.98820350380072 0.00376613355181158 no 3319 0.0014031131656812 4787 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_352 k048-0007 5.11 µM -3.00347415960198 0.00361568601216327 no 3320 0.00133458107280091 4746 6811911 SGTC_339 3091-4833 71.4 µM -3.03917774293729 0.00328477305347724 no 3321 0.00118612424109233 4699 3240077 SGTC_151 3013-0144 2.285 µM -3.05558817172381 0.00314202117246084 no 3322 0.0011230977384105 4654 906558 YHR107C CDC12 SGTC_1264 0783-0040 158 µM -3.09732360837922 0.00280379814433874 no 3323 0.000976382861096277 4770 2855798 SGTC_2752 diclazuril 33.15 µM -3.11661736110462 0.00265884299669366 no 3324 0.000914694238886 4759 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3232 9132874 49.47 µM -3.12795490987353 0.00257685464831353 no 3325 0.000880135917819554 4788 3784940 SGTC_1773 st048542 73.5835 µM -3.17920110146754 0.00223404128711857 no 3326 0.000738407963309968 4793 3237138 SGTC_2612 dictamnine 15.46 µM -3.23598149299939 0.00190288882209882 no 3327 0.000606126217809739 4774 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2298 7976326 193.81 µM -3.26700854611566 0.0017414104362829 no 3328 0.000543451995996358 4795 2235818 SGTC_1053 3366-3204 134 µM -3.27247594136383 0.00171428359575882 no 3329 0.000533049726944226 4799 3632071 YPR165W RHO1 SGTC_2968 9090663 33.37 µM -3.28098959038939 0.00167280770147698 no 3330 0.000517217809624675 4782 25236811 SGTC_1926 methyl fluorone black 53.6 µM -3.28469834307453 0.00165502722755215 no 3331 0.000510458060951397 4662 72721 Reacts with homocysteine. SGTC_687 k029-0044 34.9 µM -3.34476308209808 0.00139004083467066 no 3332 0.000411764423831948 4801 5829338 SGTC_2399 5884133 200 µM -3.34525587494753 0.00138803700301805 no 3333 0.000411033461780477 4781 722445 SGTC_2331 7980721 200 µM -3.36329520116453 0.00131647541891539 no 3334 0.000385089790266478 4791 2981221 SGTC_769 0302-0231 76 µM -3.37861037325541 0.00125838513031573 no 3335 0.000364265905073142 4779 571869 YER009W NTF2 SGTC_299 1273-0059 1.44 µM -3.46887085618164 0.000961094884536267 yes 3336 0.000261325312542884 4687 2848077 SGTC_2489 cantharidin 73.42 µM -3.4835247026158 0.000919422216683495 yes 3337 0.000247428725553906 4802 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1886 st057356 49.9 µM -3.56784737622674 0.0007102079876878 yes 3338 0.000179963020679939 4806 24207747 SGTC_1872 amphotericin b 148 nM -3.58216541615202 0.000679386501377305 yes 3339 0.000170378951291693 4804 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_431 k089-0097 107 µM -3.59980836304246 0.000643105504670924 yes 3340 0.000159225893639795 4677 5499420 SGTC_1884 5633444 25 µM -3.61614704247051 0.000611109989108083 yes 3341 0.000149510281143735 4795 5724239 SGTC_1718 roemerine 11.9335 µM -3.66331500514494 0.000526806300145715 yes 3342 0.00012448602340306 4647 235224 An aporphine alkaloid with mutagenic activity. SGTC_2021 4019055 173 µM -3.83048400509664 0.00030713799069284 yes 3343 6.39457235115008e-05 4764 44827708 YER133W GLC7 SGTC_2651 TUB2.036 5 µM -3.83440270094596 0.000303201561729322 yes 3344 6.2934891886094e-05 4768 15992207 YFL037W TUB2 SGTC_293 4049-0273 38.5 µM -3.98297306088372 0.000184345855365836 yes 3345 3.40292363929208e-05 4798 1380311 SGTC_1658 st012944 20 µM -4.08572544418786 0.000129404106859497 yes 3346 2.1969656213878e-05 4788 24207260 SGTC_1047 2043-3044 82 µM -4.17189667613977 9.55850098508572e-05 yes 3347 1.51037308939156e-05 4800 669592 SGTC_2398 5228213 48.84 µM -4.18763025683713 9.03869190905533e-05 yes 3348 1.40941123012237e-05 4805 80771 YMR134W ERG29 SGTC_457 grayanotoxin iii 135 µM -4.5313160995865 2.54255938362267e-05 yes 3349 2.93086759461744e-06 4783 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_444 curcumin 90.4 µM -4.73550614162646 1.14684342782227e-05 yes 3350 1.09254543768489e-06 4801 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2784 7567673 72.73 µM -4.80070425182313 8.83456890620928e-06 yes 3351 7.90543110041357e-07 4805 3471247 SGTC_1787 fluconazole 80 µM -5.17103552400671 1.88657427343847e-06 yes 3352 1.16400150835308e-07 4740 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1048 3161-0300 24.5 µM -5.35963449545702 8.25288963867028e-07 yes 3353 4.16952463284792e-08 4807 2165101 SGTC_2009 4012297 12.05 µM -5.41195157462069 6.52968313509e-07 yes 3354 3.11707750675542e-08 4808 45595307 SGTC_2167 5876490 200 µM -6.02737428131789 3.54347628884639e-08 yes 3355 8.3322392109701e-10 4807 686534 SGTC_453 enantio-paf c16 10 µM -7.22640803230593 5.21010559806467e-11 yes 3356 2.47968101818119e-13 4764 13871343 A lipid and platelet activating factor