SGTCid condition conc unit AOS1|YPR180W.score AOS1|YPR180W.strain.pval AOS1|YPR180W.strain.significant AOS1|YPR180W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2502 avocadyne acetate 18.59 µM 4.31063686165311 7.05392921655126e-06 yes 1 8.1392520450739e-06 6 3952079 SGTC_2634 4'-methoxyflavone 100 µM 4.13287075208149 1.57024581412911e-05 yes 2 1.79130104556436e-05 6 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3021 9087658 49.47 µM 4.13160379563646 1.57905296594355e-05 yes 3 1.80120479174334e-05 3 25237042 SGTC_2341 7987486 176.74 µM 4.0525475915601 2.23165865284945e-05 yes 4 2.53314568529583e-05 6 1258686 SGTC_1587 estradiol valerate 56.1 µM 3.86271913056579 4.99597998887702e-05 yes 5 5.60659523057322e-05 3 13791 A steroid. SGTC_358 0075-0058 9.45 µM 3.67199675701301 0.000108401640440387 yes 6 0.000120331368555306 3 1069125 SGTC_1451 4152-0210 104 µM 3.63265532724964 0.000126630101912313 yes 7 0.000140259805810391 6 659563 SGTC_2583 asiatic acid 100 µM 3.62809965029144 0.000128917454370965 yes 8 0.000142757532667455 13 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3025 9087895 49.47 µM 3.6144900641997 0.000135983551448999 yes 9 0.000150469678093128 6 17173641 SGTC_3251 9135047 49.47 µM 3.60326286903536 0.000142084292491825 yes 10 0.000157123718130847 7 17682963 SGTC_213 1246-0773 967 nM 3.44573305529051 0.000259677817057724 yes 11 0.000284756321758645 5 6251622 SGTC_2461 5755302 26.15 µM 3.37344147522706 0.000339752291828884 yes 12 0.000371174127225661 8 2788904 SGTC_2646 retinol 96.75 µM 3.35789434549424 0.000359734903120821 yes 13 0.000392693133423297 7 445354 A vitamin A analog and teratogen. SGTC_667 1498-1044 59 µM 3.31050048012697 0.000427588579557817 yes 14 0.000465646462194347 15 6739982 SGTC_573 3702-0553 84.7 µM 3.16474492729675 0.000717780317094219 yes 15 0.000776094798936685 12 1222756 SGTC_1015 4130-4525 82 µM 3.12115017802061 0.000834783342915782 yes 16 0.000900730696533821 17 1363237 SGTC_2831 7999036 19.48 µM 3.03557073174277 0.00111696811278575 no 17 0.00120040452133532 14 2988270 SGTC_531 3788-1495 174 µM 3.03249252577714 0.0011285831758959 no 18 0.00121271551887387 13 2896655 SGTC_1695 st026914 34.495 µM 3.02947984169281 0.0011400580571741 no 19 0.00122487625756908 12 3289191 SGTC_3191 9110352 49.47 µM 3.02782537163099 0.00114640506479213 no 20 0.00123160191799454 5 17122424 SGTC_866 0495-0101 262 µM 2.9596536647472 0.00143784144219528 no 21 0.00153992531537322 17 635694 SGTC_2876 9059903 25.97 µM 2.94402422856335 0.00151354762486976 no 22 0.00161987318079169 8 6916095 SGTC_2693 st077581 40.7 µM 2.94231720329729 0.00152203268362324 no 23 0.001628830249225 15 25238761 SGTC_1727 st034309 9.9045 µM 2.89394378861733 0.00178126867039178 no 24 0.00190218130467612 36 870305 SGTC_3024 9090631 49.47 µM 2.89169821283535 0.0017942255728838 no 25 0.00191582903981782 10 25236383 SGTC_1222 0366-0074 1.18 µM 2.83439658311987 0.00215526010733861 no 26 0.00229561577838952 17 286520 SGTC_2644 guaiazulene 100 µM 2.79789684536373 0.00241834947894497 no 27 0.00257182685008936 4 3515 A coloring agent. SGTC_95 0471-0001 561.058 µM 2.79482012998172 0.00244180285899744 no 28 0.00259642992996592 16 4015405 SGTC_344 k064-0035 6.43 µM 2.79102544048047 0.00247101254994207 no 29 0.00262706711821833 21 5088750 SGTC_2643 anethole 100 µM 2.78521587802989 0.00251634434782615 no 30 0.00267460482031055 10 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1431 4049-0260 9.09 µM 2.76504063063933 0.00267966986854796 no 31 0.00284578530362232 14 3854841 SGTC_2625 euphol 100 µM 2.73898436567422 0.00290474947152436 no 32 0.00308146520444904 27 6708538 A triterpene alcohol. SGTC_89 0302-0250 142.109 µM 2.73483362858932 0.00294213793520417 no 33 0.00312059060572867 22 4203518 YLR208W SEC13 SGTC_87 0100-0052 35.5 µM 2.69106688237137 0.00336359851050892 no 34 0.00356119571505101 43 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2641 levomentholum 100 µM 2.68629637843538 0.00341267133270743 no 35 0.003612448509573 6 16666 SGTC_1116 jasmonic acid  1.58368 µM 2.66787599576809 0.00360825075819887 no 36 0.00381662127135589 20 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3246 9135460 32.98 µM 2.66029218994866 0.00369165406932512 no 37 0.00390364444885679 13 41446951 SGTC_2167 5876490 200 µM 2.65910618179932 0.00370485248518677 no 38 0.00391741332088104 12 686534 SGTC_1452 4194-0072 190 µM 2.63097430614461 0.00403058253755361 no 39 0.00425702362920558 23 1343545 SGTC_365 0121-0052 13.6 µM 2.62622098649138 0.0040880839997461 no 40 0.00431693718366373 23 3101739 SGTC_2514 salinomycin 42.74 µM 2.62573768482537 0.00409397148147206 no 41 0.00432307101037357 18 23682228 A polyether potassium ionophore. SGTC_1477 0139-0234 16 µM 2.62503480245151 0.00410254739343298 no 42 0.00433200555052686 21 620880 SGTC_263 alizarin 107.927 µM 2.60191094529151 0.00439380008632394 no 43 0.00463529610311474 42 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2989 9073649 71.4286 µM 2.59733173698729 0.0044536215180014 no 44 0.00469755692350881 37 21367202 SGTC_998 3996-0085 177 µM 2.58761736462915 0.00458294165436133 no 45 0.00483211334039369 19 715391 SGTC_1043 0916-0009 19.3 µM 2.58652172122115 0.00459773546278184 no 46 0.00484750297797323 31 3101130 SGTC_431 k089-0097 107 µM 2.58175267213528 0.0046626267583228 no 47 0.00491500020612967 37 5499420 SGTC_2909 7941780 10.49 µM 2.56766977370692 0.00485904462555484 no 48 0.00511923198203015 20 1243215 SGTC_628 1636-0253 16 µM 2.55123888242205 0.00509750644094002 no 49 0.00536703623549064 38 4456143 SGTC_3080 9117754 49.47 µM 2.52437104663716 0.00550993967918669 no 50 0.00579527599751058 29 9550191 SGTC_950 1165-0508 94.1 µM 2.47853462515794 0.00628232244987087 no 51 0.0065961652966666 25 6148369 SGTC_453 enantio-paf c16 10 µM 2.44780928953128 0.00685233085798562 no 52 0.00718638543374277 51 13871343 A lipid and platelet activating factor SGTC_339 3091-4833 71.4 µM 2.44614851329383 0.00688440296445995 no 53 0.00721957546451873 55 3240077 SGTC_2642 cholecalciferol 100 µM 2.43937508785496 0.00701658506022705 no 54 0.00735634408084322 16 9821465 A vitamin D precursor, similar to steriods. SGTC_880 0833-0487 87.2 µM 2.41784476412673 0.00745174037156109 no 55 0.00780636794342147 19 76075 SGTC_2834 9001755 58.44 µM 2.414826309029 0.00751461004621013 no 56 0.00787135739760893 29 2989575 SGTC_1262 0737-0114 49.6 µM 2.40199160297156 0.00778718354493153 no 57 0.00815304136427568 31 765919 SGTC_1906 st060206 94.7 µM 2.3833728529114 0.00819805135123952 no 58 0.00857740469888107 21 5133468 SGTC_526 4469-0568 170 µM 2.37669888184067 0.00834989941050998 no 59 0.00873417082990695 40 2901964 SGTC_149 3970-0822 46.1 µM 2.36902595606296 0.00852752275012369 no 60 0.00891750087892505 49 3114250 YBL034C STU1 SGTC_1246 0422-0085 105 µM 2.35780811651346 0.0087931738819251 no 61 0.00919159623874172 43 264295 SGTC_1117 retinoic acid 1.10837 µM 2.35428742400549 0.00887803025370436 no 62 0.00927912752212232 24 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3164 9100705 49.47 µM 2.35053196153591 0.00896933524229254 no 63 0.00937329879416582 18 17174235 SGTC_987 1497-1013 404 µM 2.34606721674536 0.00907895415676278 no 64 0.00948634278814355 29 1676435 SGTC_3165 9101544 49.47 µM 2.33039662532502 0.00947303905413609 no 65 0.0098925989876788 27 5002184 SGTC_1302 1159-0335 255 µM 2.32796296670588 0.00953556407840777 no 66 0.00995703510516012 26 649284 SGTC_949 1165-0505 146 µM 2.32565688908592 0.00959514393391654 no 67 0.0100184310375269 16 6244267 SGTC_1903 st060211 78.3 µM 2.32564112179569 0.00959555241532146 no 68 0.0100188519532593 34 688960 SGTC_1118 chelidonine 707.474 nM 2.3212754247662 0.00970924042004354 no 69 0.0101359918509749 23 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2419 paclitaxel 166.5 µM 2.30011837442258 0.0102770228948878 no 70 0.0107207572813787 39 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2608 thymoquinone 42.66 µM 2.2871595679629 0.0106389117413096 no 71 0.0110932555112947 31 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_129 0088-0017 176.636 µM 2.28494297817285 0.0107019115830393 no 72 0.0111580857592317 23 182446 SGTC_2814 7977482 42.97 µM 2.28014863373227 0.0108392884651106 no 73 0.0112994373137065 53 6456762 SGTC_2459 5811157 9.22 µM 2.27658454927559 0.0109424057887558 no 74 0.0114055231993334 28 2870684 YBR192W RIM2 SGTC_1946 st076057 65.1 µM 2.26563558758388 0.0112645418034174 no 75 0.0117368521438767 15 953009 SGTC_3029 9088683 49.47 µM 2.26304289121008 0.011342019330192 no 76 0.0118165227101706 36 25236615 SGTC_1935 st074532 41.6 µM 2.25451868572487 0.0116000212107469 no 77 0.0120817782494636 42 2829742 SGTC_2116 5511452 16.8835 µM 2.24522891116601 0.0118869828455701 no 78 0.0123767205018836 39 870744 SGTC_568 1193-0097 7.48 µM 2.24434017470214 0.0119147560136156 no 79 0.0124052612700779 65 3646150 SGTC_118 0083-0097 135.343 µM 2.2412901175325 0.0120104993181074 no 80 0.0125036443416833 75 5207356 SGTC_1312 1218-2183 165 µM 2.23854274735714 0.0120973114971688 no 81 0.0125928415151324 35 6744073 SGTC_521 r062-0005 13.8 µM 2.22683162319969 0.012473491923413 no 82 0.0129792645276224 26 2832033 SGTC_996 3970-0799 1.8 µM 2.21469074016989 0.0128741291433883 no 83 0.0133906494390875 63 6615648 YGL040C HEM2 SGTC_81 0411-0046 9.971 µM 2.21271830432145 0.0129402576017121 no 84 0.0134585363178544 88 12925265 SGTC_1447 4239-0816 81.9 µM 2.20850081350737 0.0130826404961431 no 85 0.0136046905827574 47 1341554 SGTC_397 arbidol 50 µM 2.20834822375519 0.0130878172237089 no 86 0.0136100040522223 39 131410 A RNA synthesis inhibitor. SGTC_405 ebelactone b 50 µM 2.20564632630005 0.0131797748799003 no 87 0.0137043863681719 19 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2692 st077426 47.7 µM 2.20503150295994 0.0132007778717018 no 88 0.0137259419896102 50 25238571 SGTC_593 1203-0218 61.7 µM 2.20362124469307 0.0132490630012153 no 89 0.0137754959676058 35 3666956 SGTC_227 fluconazole 33.516 µM 2.20347446069428 0.0132540974212264 no 90 0.0137806625530303 103 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_119 0121-0043 24.815 µM 2.18752352401424 0.0138111250627654 no 91 0.0143521639257108 73 1092378 SGTC_2015 5119600 184 µM 2.18503806735702 0.0138997138969499 no 92 0.0144430277789571 56 2828786 SGTC_2648 atorvastatin 78.68 µM 2.1831345771947 0.0139678906701882 no 93 0.0145129504486002 32 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1670 st016595 4.04 µM 2.17718522001505 0.0141828388514959 no 94 0.0147333753085742 32 597879 SGTC_2014 4013930 200 µM 2.1697677078872 0.0144548173545675 no 95 0.0150122239195225 47 64556 SGTC_1395 3486-0190 4.35 µM 2.16087068346077 0.0147869572709979 no 96 0.0153526650395843 36 6748079 SGTC_1746 st038117 42 µM 2.14787117512519 0.0152840411458608 no 97 0.0158619954133109 42 2898218 SGTC_96 0929-0093 37.281 µM 2.14644563239055 0.0153394153526515 no 98 0.0159187209818694 45 6991579 SGTC_1177 0983-0204 23.6 µM 2.13026584764029 0.0159800778222245 no 99 0.016574835724454 57 766818 SGTC_3284 9108171 64.8615 µM 2.11992720059112 0.0164013524414017 no 100 0.0170060925521819 40 8687505 SGTC_781 4335-2806 94.4 µM 2.11849814022384 0.0164603246818437 no 101 0.0170664511265082 47 845254 SGTC_152 4469-0003 551.229 µM 2.1140864600499 0.0166435255631458 no 102 0.0172539417105585 81 697280 SGTC_3257 9139206 32.98 µM 2.10904505946066 0.0168550098290695 no 103 0.0174703462162294 44 4910041 SGTC_600 1495-0418 41.6 µM 2.10516942722604 0.0170191492775589 no 104 0.0176382812562354 55 5377768 SGTC_418 lividomycin a 100 µM 2.09859704437837 0.0173006241751803 no 105 0.0179262185659464 34 72394 An antibiotic. SGTC_1433 4060-0023 7.6 µM 2.08841438225187 0.0177445658542973 no 106 0.0183802356179309 46 3840627 SGTC_3160 9100216 49.47 µM 2.07823021614923 0.0181982583441729 no 107 0.0188440801568903 23 17191039 SGTC_2978 9011784 42.97 µM 2.07233559863122 0.0184653458755315 no 108 0.0191170773763062 38 2994934 SGTC_1924 st058459 75.1 µM 2.07100164698684 0.0185262488323157 no 109 0.0191793210714088 31 688683 SGTC_2338 7999974 200 µM 2.06382599554049 0.0188568031770226 no 110 0.0195171086957102 55 315925 SGTC_1439 4092-1168 46 µM 2.06130615844685 0.0189740665655602 no 111 0.0196369205282347 36 2886240 SGTC_146 3448-8650 53.125 µM 2.06025659064152 0.0190230920096697 no 112 0.0196870087268337 57 2891488 YIL048W NEO1 SGTC_2141 5621638 7.665 µM 2.05936485053411 0.0190648299059008 no 113 0.0197296501520049 38 2856238 SGTC_962 1254-0300 21.5 µM 2.05872729966365 0.0190947181903769 no 114 0.019760184744547 29 7340576 SGTC_830 4076-0286 57.8 µM 2.046072784021 0.0196962542530495 no 115 0.0203746051128564 46 6866659 SGTC_1257 0669-0121 16 µM 2.0306998101042 0.0204485854116276 no 116 0.021142727817368 43 4307855 SGTC_2107 5363541 170.161 µM 2.01677445760111 0.0211509545806069 no 117 0.0218595278182924 55 244052 SGTC_2754 granisetron 64.02 µM 2.01371205231848 0.0213081246228744 no 118 0.02201988695446 57 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.0124607570751 0.0213726277438746 no 119 0.0220856947114042 58 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2445 5742597 35.57 µM 2.00647568143866 0.0216834407470448 no 120 0.0224027604071672 56 1774255 SGTC_2143 5623677 140.463 µM 2.00304021548487 0.0218635681102584 no 121 0.0225864860511976 39 5375313 SGTC_348 k064-0012 10.7 µM 2.00176420957076 0.0219307923583268 no 122 0.0226550484635296 73 5066323 SGTC_296 1222-0039 74.9 µM 1.99251320664398 0.022423404261357 no 123 0.0231573888059917 42 5984176 SGTC_2146 5545642 200 µM 1.99117851721224 0.0224952404487807 no 124 0.0232306323880118 50 825326 SGTC_1434 4073-0095 163 µM 1.98259523209991 0.0229618650034488 no 125 0.0237063301926616 41 24133745 SGTC_126 0417-1624 672.48 µM 1.97929352065374 0.0231435188444873 no 126 0.0238914843418383 82 41912 YDL195W SEC31 SGTC_2162 5663267 200 µM 1.9624781501655 0.024087545344958 no 127 0.0248534210124717 68 6456493 SGTC_1490 4089-0339 670 nM 1.96086840561765 0.0241795906143848 no 128 0.0249471878762684 50 742542 SGTC_2256 7954252 200 µM 1.9589586301383 0.0242891746530485 no 129 0.0250588159264248 62 2972920 SGTC_515 4092-1064 102 µM 1.95287094582949 0.0246412768060649 no 130 0.0254174446096216 78 717353 SGTC_2714 st079313 56.9 µM 1.94960488967314 0.0248319390539882 no 131 0.0256116150780224 41 2939799 SGTC_906 1165-0455 526 µM 1.94657549643283 0.0250098902039127 no 132 0.0257928243320634 42 3252859 SGTC_1379 2144-0755 36.5 µM 1.94086908733707 0.0253479974091775 no 133 0.0261370792030177 53 5392327 SGTC_3211 9128781 49.47 µM 1.9324809667805 0.0258519421311019 no 134 0.026650084522863 72 17194361 SGTC_2537 larixol 68.93 µM 1.92736810365529 0.0261632073857884 no 135 0.0269668858672076 67 6708759 SGTC_1435 4092-0789 56.7 µM 1.92211455518009 0.0264862955545408 no 136 0.0272956725013073 65 2248285 SGTC_988 1497-1057 103 µM 1.90828307878761 0.0273528939321551 no 137 0.0281773194149487 57 3533044 SGTC_1706 st031321 9.9705 µM 1.90125794335974 0.0278020251200968 no 138 0.0286341174209844 47 6103185 SGTC_557 1315-0110 16.2 µM 1.89480327662538 0.0282200851256773 no 139 0.0290592344779956 48 6833801 SGTC_1486 3970-0793 4.53 µM 1.88280885495288 0.0290108453881757 no 140 0.0298631383025386 61 2844330 SGTC_345 1362-0200 395 µM 1.88128517288016 0.0291126032995514 no 141 0.029966568434598 64 1419823 SGTC_2331 7980721 200 µM 1.86571832489924 0.0301693136489542 no 142 0.0310403922439187 78 2981221 SGTC_2121 5257820 149.641 µM 1.86136232076101 0.0304706380262968 no 143 0.0313465138989678 46 791256 SGTC_651 3253-0966 34.4 µM 1.85320105948235 0.0310419006014226 no 144 0.0319267729427166 61 781462 SGTC_78 0336-0123 156.75 µM 1.85199548184738 0.0311270337076244 no 145 0.0320132358525595 56 6765896 SGTC_3288 9119690 36.221 µM 1.84503194872616 0.0316225586411743 no 146 0.0325164456267646 86 17595618 YKL019W RAM2 SGTC_1526 st051518 75 µM 1.83887182829414 0.0320663302485402 no 147 0.0329670201457327 56 673993 SGTC_777 1315-0167 517 µM 1.836077845025 0.0322692955601291 no 148 0.0331730722157053 59 4221767 SGTC_2478 5763493 32.33 µM 1.83469822308504 0.0323699067702687 no 149 0.0332752078646047 67 1365576 YLR208W SEC13 SGTC_1736 st036774 51 µM 1.81829258307447 0.0335862749271223 no 150 0.0345097129065907 56 1272247 SGTC_1640 st009078 66.4 µM 1.81432731569712 0.0338858510744321 no 151 0.0348136742772134 62 690618 SGTC_2649 anisomycin 9.56 µM 1.8140451819521 0.0339072497873845 no 152 0.0348353850120965 66 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2386 9075165 157.42 µM 1.80389700020649 0.0346843694315701 no 153 0.0356237276724569 66 16452277 SGTC_1636 st007707 68.9 µM 1.803074136649 0.0347480179986858 no 154 0.0356882861752493 54 403051 SGTC_2770 toltrazuril 17.5 µM 1.8016018483729 0.0348621389301311 no 155 0.035804035130857 47 68591 Kills coccidiodes. SGTC_1807 st050092 58.9 µM 1.79682729524775 0.0352343456660386 no 156 0.0361815208418276 62 5008496 SGTC_15 0266-0086 27.098 µM 1.79665242707041 0.0352480393958347 no 157 0.0361954078928248 82 1712902 YIL048W NEO1 SGTC_952 1185-0122 232 µM 1.7956875742294 0.0353236744531149 no 158 0.0362721095881058 69 678600 SGTC_1799 st045822 46.1415 µM 1.7835910504698 0.0362832684897413 no 159 0.0372450704532216 70 3674992 SGTC_3168 9103419 49.47 µM 1.77994234060298 0.0365768676001031 no 160 0.037542698730866 36 16649256 SGTC_2647 atorvastatin 60.16 µM 1.77710833268709 0.0368062491631528 no 161 0.0377752087268499 49 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_611 3453-1652 23.7 µM 1.77370100576537 0.0370835905090072 no 162 0.0380563099999895 94 1560575 SGTC_1682 st012968 530 nM 1.77258367732748 0.0371749071182491 no 163 0.0381488592086137 53 24207270 SGTC_582 0987-0078 156 µM 1.7610511074865 0.0381282138901434 no 164 0.03911487660864 77 1625765 SGTC_191 3914-0123 66.505 µM 1.75665341003394 0.0384969484123905 no 165 0.0394884516492955 74 3144412 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.75450648997193 0.0386780145299376 no 166 0.0396718794165401 57 23665772 A membrane-active detergent. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.75296050301218 0.0388088286145339 no 167 0.0398043934932921 106 16725076 SGTC_282 k297-0036 65.7 µM 1.74912790847174 0.0391346791004911 no 168 0.0401344560177753 67 5061378 SGTC_1688 st021091 57.6 µM 1.74846941430078 0.039190888399524 no 169 0.0401913886566061 68 3656366 SGTC_1101 ebselen 5.29 µM 1.74804818756569 0.0392268789133829 no 170 0.0402278418227145 87 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_20 0481-0013 4.944 µM 1.74567536060476 0.0394301211825464 no 171 0.0404336894564392 92 182045 SGTC_2480 5767542 37.17 µM 1.73543951566773 0.040316702828356 no 172 0.0413314930036806 59 2867358 SGTC_2602 kawain 100 µM 1.72159904196355 0.0415411745470389 no 173 0.0425710884338679 74 5369129 SGTC_2217 6934799 96.0675 µM 1.71988971944781 0.0416944675835169 no 174 0.0427262448082017 54 675606 SGTC_645 0845-0943 5.41 µM 1.71865199966289 0.041805752761144 no 175 0.0428388785723564 66 1885106 SGTC_3009 9080819 71.4286 µM 1.71604519281008 0.0420409213317275 no 176 0.0430768856096038 73 17027216 SGTC_719 2810-4230 27.3 µM 1.70854352599709 0.0427236505727664 no 177 0.0437677686352612 48 721079 SGTC_3151 9099821 49.47 µM 1.69723374667866 0.0437698717099772 no 178 0.0448262386848635 92 17174189 SGTC_3226 9131256 49.47 µM 1.69586100240901 0.0438982534157468 no 179 0.0449561032692554 45 17178073 SGTC_665 3914-0008 307 µM 1.69472741244692 0.0440044977560033 no 180 0.0450635714892289 56 1069549 SGTC_3324 9138759 60.749 µM 1.69275828423583 0.0441895447651063 no 181 0.045250743032847 66 45595710 SGTC_173 1273-0061 2.693 µM 1.68297201143171 0.0451185260558789 no 182 0.0461902548665014 110 2847414 YPL266W DIM1 SGTC_2736 butenafine 14.65 µM 1.68238836414363 0.0451744228009084 no 183 0.0462467781147649 78 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.67143633262898 0.0462336846861691 no 184 0.0473177622478442 123 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1058 3448-5425 97.3 µM 1.6712873966333 0.0462482258141419 no 185 0.0473324623270458 93 7279705 SGTC_1564 D-Arginine 115 µM 1.66973971165221 0.0463995490284776 no 186 0.0474854365471396 102 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_510 ag-490 170 µM 1.66833362699887 0.0465373717748388 no 187 0.0476247580442542 47 5328779 SGTC_231 b-estradiol 524 µM 1.66789482344037 0.046580449981138 no 188 0.0476683037365712 62 450 A steroid. SGTC_3162 9099653 49.47 µM 1.66783946256264 0.0465858871397312 no 189 0.0476737998666897 57 25237511 SGTC_2239 6685329 187.64 µM 1.66493220913145 0.0468721336403741 no 190 0.0479631406840129 60 805680 SGTC_2305 7443522 69.23 µM 1.66231577138116 0.0471309510944563 no 191 0.0482247385899794 83 5415886 SGTC_2861 9024595 19.48 µM 1.65871163434395 0.0474893462517097 no 192 0.0485869569305943 33 16482810 SGTC_374 0880-0231 82.3 µM 1.65598735100714 0.0477616950819075 no 193 0.0488621902063005 95 6833587 SGTC_2255 7941087 197.44 µM 1.65264430564897 0.0480976095126537 no 194 0.049201637707719 80 935561 SGTC_474 dl-dihydrosphingosine 5 µM 1.64683200005081 0.0486861376751387 no 195 0.0497962909844879 85 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2690 usnic acid 100 µM 1.64633055840124 0.0487371799894251 no 196 0.0498478606580993 78 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2002 4023503 131 µM 1.64445514862921 0.0489284593090745 no 197 0.0500411107871798 98 4736863 YCR052W RSC6 SGTC_2798 7813637 45.45 µM 1.64317919246726 0.0490589408811714 no 198 0.0501729318271138 110 956368 SGTC_2458 5808907 16.39 µM 1.64254508688769 0.0491238889716049 no 199 0.0502385451625993 94 2731747 SGTC_1114 scopoletin 1.73284 µM 1.63849991511444 0.0495398325663966 no 200 0.0506587258706333 67 5280460 A coumarin with genotoxic properties. SGTC_1476 4112-3294 3.34 µM 1.63769120881422 0.0496233237358103 no 201 0.0507430627113087 70 704369 SGTC_2645 abamectin 100 µM 1.63452968423529 0.0499507988478768 no 202 0.0510738392773762 86 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2568 diosmetin 100 µM 1.6343141208881 0.0499731898124891 no 203 0.0510964550781909 99 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1136 pergolide 1.05886 µM 1.631908347461 0.0502236254634955 no 204 0.0513493976412246 112 47811 A dopamine receptor agonist. SGTC_353 1988-1175 58.3 µM 1.63054272978345 0.0503662277054983 no 205 0.0514934209759596 95 2788357 SGTC_2350 9023895 38.85 µM 1.62858060275863 0.0505716840307133 no 206 0.0517009166519421 89 2997209 SGTC_2045 5106652 78.05 µM 1.620951766341 0.0513768585008073 no 207 0.0525139917508372 61 673349 SGTC_2788 5282734 71.43 µM 1.60631608287843 0.0529500818420596 no 208 0.0541022392063484 106 743706 SGTC_3089 9117425 49.47 µM 1.60135049795205 0.0534924422165355 no 209 0.0546496551103411 69 9401657 SGTC_2132 5317594 122.667 µM 1.59565780856892 0.0541196252748948 no 210 0.0552826066540809 74 794577 SGTC_2879 9041815 71.43 µM 1.59515918071327 0.0541748368703736 no 211 0.055338322098531 43 4942971 SGTC_2133 5320837 200 µM 1.59485876471402 0.0542081225615548 no 212 0.0553719112398393 61 2841355 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.59397916893968 0.0543056736624775 no 213 0.055470350336627 103 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1100 amiodarone 5.07 µM 1.59006837401123 0.0547410808893605 no 214 0.0559096968996538 67 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_130 0136-0219 337.655 µM 1.58996252441447 0.0547529038706123 no 215 0.0559216263014403 96 234244 SGTC_2272 7805186 180 µM 1.58534120164663 0.055271058133761 no 216 0.056444416303292 87 2956062 YPR165W RHO1 SGTC_619 1652-1634 108 µM 1.57254017851926 0.0567265757758541 no 217 0.0579126643851854 86 5400454 SGTC_1938 st074717 56.4 µM 1.57249145994989 0.056732172354584 no 218 0.0579183090946282 73 17250979 SGTC_1663 st014140 55.4 µM 1.55909733917897 0.0582873981634131 no 219 0.0594866716703664 74 4207120 SGTC_1512 0259-0544 12.2 µM 1.55666625189128 0.0585732356657661 no 220 0.0597748725839516 103 18476 SGTC_2772 vinpocetine 57.06 µM 1.55395294593013 0.058893553615367 no 221 0.0600978204840111 89 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3040 9091894 49.47 µM 1.54567490752555 0.0598793115486049 no 222 0.0610915501238274 66 25236966 SGTC_219 mitoxanthrone 164.414 µM 1.54358786355616 0.0601298677241832 no 223 0.0613441035044555 94 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1657 st012939 43.4 µM 1.53943963928056 0.0606303115205827 no 224 0.0618485015689873 59 24207257 SGTC_428 3448-4153 16.5 µM 1.53724373766696 0.0608965418157261 no 225 0.0621168167036119 91 3834874 SGTC_640 3381-0960 37.1 µM 1.53654148659735 0.0609818750936582 no 226 0.0622028154770046 98 1745025 SGTC_3081 9117243 49.47 µM 1.52948859831506 0.0618440913330765 no 227 0.0630716817282082 130 45595589 SGTC_338 4055-0136 114 µM 1.52816721771527 0.0620066835303102 no 228 0.0632355129161478 75 2900563 SGTC_50 0929-0078 56.389 µM 1.52698651210435 0.062152248070737 no 229 0.0633821826747267 75 1377751 SGTC_1634 st006576 41 µM 1.51777285008709 0.0632973381790036 no 230 0.0645358358310752 92 3915356 SGTC_3076 9116187 49.47 µM 1.51642254761614 0.0634665273260777 no 231 0.0647062706194413 75 27241210 SGTC_2829 7992743 58.44 µM 1.51627783713639 0.0634846800086994 no 232 0.0647245566529088 77 16462845 SGTC_1425 4048-4433 7.33 µM 1.51593651081765 0.0635275124597204 no 233 0.0647677035263835 107 23734946 SGTC_1223 0764-0573 147 µM 1.51396553731866 0.0637752865464531 no 234 0.0650172901978153 81 1609797 SGTC_1996 st072960 66.8 µM 1.51250003579035 0.0639600037544862 no 235 0.0652033517699799 97 1719405 SGTC_921 1561-0023 372 µM 1.51174582027776 0.0640552298679031 no 236 0.0652992686300623 110 24050882 SGTC_144 4161-2749 112.381 µM 1.50938229249515 0.0643543593862704 no 237 0.0656005577954528 123 797501 YMR168C CEP3 SGTC_1794 st048918 76.9 µM 1.50095706608452 0.0654294988555588 no 238 0.0666833333232455 69 672303 SGTC_3170 9103054 49.47 µM 1.50029216882903 0.0655149356790159 no 239 0.0667693685558926 96 16432970 SGTC_463 ikarugamyin 104 µM 1.49658435176777 0.065992963716907 no 240 0.0672507221675714 42 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1150 3909-7983 10.9 µM 1.4963363040005 0.06602503931687 no 241 0.0672830195455915 121 23965914 SGTC_136 0097-0015 404.482 µM 1.49582969777592 0.066090587203638 no 242 0.0673490201125143 106 4861337 SGTC_177 1327-0068 8.361 µM 1.492778790271 0.0664863992308187 no 243 0.067747550490463 119 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1578 josamycin 24.2 µM 1.49062733037198 0.0667666222614308 no 244 0.068029682366316 97 5282165 A P450 substrate. SGTC_1427 4048-4900 550 nM 1.49035943504282 0.0668015789402928 no 245 0.0680648762584938 100 24132586 SGTC_322 k048-0136 19.3 µM 1.48547533744671 0.0674413723368811 no 246 0.0687089758871596 112 6823282 SGTC_2156 5649887 115 µM 1.47930634960894 0.0682562364334849 no 247 0.0695292283027917 111 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3297 9117502 71.43 µM 1.47775861263489 0.0684618651800944 no 248 0.0697361998979974 58 7453720 SGTC_1430 4049-0248 69.1 µM 1.47461091533426 0.0688815348989991 no 249 0.0701585893133335 99 22774488 SGTC_1939 st074455 53.6 µM 1.46359435636233 0.0703659562948488 no 250 0.0716524077463407 99 1644229 SGTC_757 1066-0008 322 µM 1.46251191269279 0.0705131267695937 no 251 0.0718004911578676 105 6842497 SGTC_1352 1496-0991 99 µM 1.46179902925774 0.070610180499461 no 252 0.0718981451073781 102 3000039 SGTC_3142 9086498 49.47 µM 1.4554028109899 0.0714855762448393 no 253 0.0727788893372037 145 25236367 SGTC_1224 0823-0416 294 µM 1.45506703131702 0.0715317605967137 no 254 0.07282535261815 91 3598164 SGTC_3218 9131285 49.47 µM 1.45065169982492 0.0721411932211731 no 255 0.0734384356598117 105 17156417 SGTC_91 0417-1751 58.384 µM 1.45007969207343 0.0722204357631628 no 256 0.0735181487406828 113 6795624 SGTC_1112 tnp00069 1.16933 µM 1.44668214012768 0.0726924879007661 no 257 0.073992984412952 97 145826 SGTC_1370 2001-0092 44.6 µM 1.43879671214929 0.0737971828793139 no 258 0.0751040641064116 111 790957 SGTC_775 4577-0580 57.3 µM 1.43619520336076 0.074164437670028 no 259 0.0754734017733687 104 2006902 SGTC_1148 3909-7663 27.7 µM 1.42546558995748 0.0756939013684726 no 260 0.0770113300023837 94 4084526 SGTC_215 1287-0124 461.5 µM 1.42423043060131 0.0758714994938644 no 261 0.0771898893240292 80 5560863 SGTC_3042 9091578 49.47 µM 1.4232734883596 0.0760093120321421 no 262 0.0773284446513451 89 25236497 SGTC_1798 st045719 60.953 µM 1.42309192714009 0.0760354807837138 no 263 0.0773547541450871 109 3980186 SGTC_2093 5331342 194.4 µM 1.42218759011416 0.0761659267156635 no 264 0.0774859002055527 107 33839 SGTC_690 glyoxal 20.3 µM 1.42215009764765 0.0761713384849007 no 265 0.077491340968923 130 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3166 9102297 49.47 µM 1.4209446326007 0.0763454947640464 no 266 0.077666428105886 98 25237072 SGTC_1111 tnp00062 510.699 nM 1.41834307740903 0.0767223796850645 no 267 0.0780453128719197 101 676306 SGTC_1520 flindersine 88 µM 1.41653399021884 0.0769852933187237 no 268 0.0783096098236237 115 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1321 1326-2144 215 µM 1.41484071508493 0.0772319959605631 no 269 0.0785576017344759 109 3513030 SGTC_901 1112-0062 60.1 µM 1.41096253825057 0.077799291674442 no 270 0.0791278301570785 98 1908457 SGTC_572 0960-0087 17.7 µM 1.40872586424457 0.0781279049548 no 271 0.0794581219746716 150 6796365 SGTC_1054 3429-0080 167 µM 1.40774158336575 0.0782728491822778 no 272 0.0796038018672921 111 1162877 SGTC_1216 1165-0504 9.65 µM 1.40468932538132 0.0787236184260479 no 273 0.0800568406852277 118 6304004 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.4041572326103 0.0788024008955053 no 274 0.0801360169811987 120 1377 SGTC_1183 1254-0324 198 µM 1.40285349548321 0.0789956866881919 no 275 0.0803302654321169 90 5799357 SGTC_1788 fluconazole 20 µM 1.3965461331271 0.0799358596856413 no 276 0.081275049242884 114 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1432 4049-0298 68.4 µM 1.39639114898598 0.0799590676113137 no 277 0.0812983694893748 97 741646 SGTC_548 1436-0017 110 µM 1.38406962733111 0.0818204887268207 no 278 0.0831685679659171 109 9677137 SGTC_591 4299-0174 154 µM 1.38400190539056 0.0818308090146263 no 279 0.0831789356552801 99 5509088 SGTC_691 1548-0686 185 µM 1.37770795047564 0.0827942465773187 no 280 0.0841467378401156 143 46495133 SGTC_2159 5658611 73.75 µM 1.37373216943284 0.0834072166433665 no 281 0.0847624229881492 110 793844 SGTC_2651 TUB2.036 5 µM 1.37036051414746 0.0839297126791569 no 282 0.0852871957782542 137 15992207 YFL037W TUB2 SGTC_3014 9081533 49.47 µM 1.36909940778149 0.0841257731565813 no 283 0.0854841017127387 135 21367265 SGTC_2284 7945075 39.21 µM 1.36539216727026 0.0847041177140763 no 284 0.0860649122024914 116 1245402 SGTC_1984 st072354 53.1 µM 1.3612771019704 0.0853495707245026 no 285 0.0867130681916559 110 5762938 SGTC_315 k915-0449 187 µM 1.36119173008787 0.085363000311563 no 286 0.0867265534714055 105 20970215 YNL149C PGA2 SGTC_878 0828-0289 13.7 µM 1.36034986859848 0.085495515718083 no 287 0.0868596172307036 122 745350 YLR208W SEC13 SGTC_2408 sulbentine 18.36 µM 1.3569274873101 0.0860358110192224 no 288 0.0874021259848269 127 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1796 st049173 110.4 µM 1.35402051276304 0.0864967416291378 no 289 0.087864916742196 119 94134 SGTC_1429 4049-0205 9.46 µM 1.35394343666562 0.0865089879089582 no 290 0.0878772120914945 101 22774478 SGTC_1507 4075-3230 155 µM 1.35312892137839 0.0866384818720318 no 291 0.0880072238104953 97 659771 SGTC_1322 1348-1070 12 µM 1.35069720465636 0.087025945023307 no 292 0.0883962240512866 114 6758089 SGTC_1846 st056244 14.8 µM 1.34944525338312 0.087225931555338 no 293 0.0885969968653609 98 5393182 SGTC_2372 9071633 200 µM 1.34561900057212 0.0878392635244849 no 294 0.0892127103744902 109 21321366 SGTC_3010 9080089 71.4286 µM 1.34530315302572 0.0878900358992215 no 295 0.0892636778841727 101 17027233 SGTC_1215 3852-0577 11.2 µM 1.34024318305016 0.0887064106442384 no 296 0.0900831482708252 114 2884876 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.33777749499145 0.0891062649063309 no 297 0.0904844900985917 121 23847180 SGTC_765 1319-0117 244 µM 1.33686100484248 0.0892552312025152 no 298 0.090634005801722 112 3487746 YGL099W LSG1 SGTC_681 1642-0006 26.6 µM 1.33085183031819 0.0902365555068462 no 299 0.0916188848455596 125 4446530 SGTC_1900 st060200 72.8 µM 1.32922844209433 0.0905030317051734 no 300 0.0918863071061761 128 688945 SGTC_1527 coumarin 137 µM 1.32610488953089 0.0910173998801032 no 301 0.0924024783943721 132 323 A hepatotoxic, DNA x-linker. SGTC_2251 lansoprazole 556 µM 1.32320815258808 0.0914963524428731 no 302 0.0928830827910679 104 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1756 st041558 35.5 µM 1.31588432126891 0.0927156174776098 no 303 0.0941064359542288 129 3955792 SGTC_2088 5278280 127.392 µM 1.31533286456756 0.0928079076556882 no 304 0.0941990287941585 122 791502 SGTC_1702 st027038 51 µM 1.30833959524531 0.0939841794484536 no 305 0.0953790754185338 111 5521182 SGTC_1125 tnp00248 1.32998 µM 1.30756592657833 0.0941149838046631 no 306 0.0955102901267098 152 24207736 SGTC_2130 NSC 7 2.4545 µM 1.30715880523284 0.0941838698243383 no 307 0.0955793914983725 128 21448 SGTC_929 2805-0021 398 µM 1.30675258767158 0.0942526399844736 no 308 0.0956483761304779 143 3098024 SGTC_2863 9028737 58.44 µM 1.30635114607863 0.094320637982115 no 309 0.0957165856837143 103 6460917 SGTC_1643 st009866 20.2 µM 1.30627095450076 0.0943342255296468 no 310 0.0957302154443252 109 3156273 YOR207C RET1 SGTC_1217 1183-1422 255 µM 1.30525076661426 0.094507210738389 no 311 0.0959037363136855 124 2849664 SGTC_2427 5545055 42.75 µM 1.30493362442821 0.094561033658374 no 312 0.0959577252347528 133 5372858 SGTC_1382 3002-2117 298 µM 1.3024777431496 0.0949785920586189 no 313 0.0963765607745501 127 1497314 SGTC_638 3970-0837 4.09 µM 1.29345725925437 0.096523946785755 no 314 0.0979264786573765 98 4118451 YLR208W SEC13 SGTC_1499 4480-0877 67.3 µM 1.29242696467554 0.0967016216274693 no 315 0.0981046617947927 109 2861909 SGTC_2650 prasterone 100 µM 1.2890358574907 0.0972881161357228 no 316 0.0986928104602618 96 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_688 0527-0193 473 µM 1.28538024511086 0.0979232755717068 no 317 0.0993297205204671 127 4007154 SGTC_1811 st050069 61.5 µM 1.28494612153958 0.097998905580198 no 318 0.0994055561696599 113 3877702 SGTC_1153 4055-0057 267 µM 1.28456968305168 0.0980645207349387 no 319 0.0994713492513956 149 882706 SGTC_2075 5212009 200 µM 1.28390214018759 0.0981809560158972 no 320 0.099588099163604 119 780898 SGTC_2306 7482397 179.52 µM 1.28340729371462 0.0982673342979687 no 321 0.0996747099460196 139 891448 SGTC_678 1218-2179 85.9 µM 1.27768932181318 0.0992694792606736 no 322 0.100679495896241 137 6820081 YOR116C RPO31 SGTC_1426 4048-4480 71.7 µM 1.2733390021555 0.100036916827367 no 323 0.101448886192665 122 14224343 SGTC_266 formosanin C 406 nM 1.27074508423497 0.100496565251956 no 324 0.101909675489878 149 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1753 st043925 64 µM 1.26848887425306 0.100897622449273 no 325 0.102311710689072 124 670181 SGTC_103 0844-0104 51.839 µM 1.26791090636078 0.101000547805402 no 326 0.102414884423758 187 5375804 SGTC_2761 levamisole 97.89 µM 1.26686149160604 0.101187624703991 no 327 0.102602410051479 101 26879 An alkaline phosphatase inhibitor. SGTC_1979 st071809 45.3 µM 1.26412644592182 0.101676381762483 no 328 0.103092322931808 126 4976333 SGTC_1948 st076329 66.6 µM 1.26346074811159 0.101795602701701 no 329 0.103211822191829 118 24208413 SGTC_1581 himbacine 57.9 µM 1.26273357582667 0.10192594946322 no 330 0.103342471629743 123 5281825 An alkaloid muscarinic receptor antagonist. SGTC_274 sirtinol 40.1 µM 1.26071466780792 0.10228847856237 no 331 0.103705833689503 131 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.2595909209148 0.102490672162244 no 332 0.103908486209092 133 551469 SGTC_2177 5811945 192 µM 1.25937420763173 0.102529698363595 no 333 0.103947600523868 127 5343475 SGTC_2696 st077691 74.316 µM 1.25920672825286 0.102559865815894 no 334 0.103977835985405 137 757133 SGTC_1221 2958-7315 257 µM 1.25834492051231 0.102715202150179 no 335 0.104133521089521 144 4562705 SGTC_1348 1493-0373 93.8 µM 1.25769832742477 0.102831859389615 no 336 0.104250438693653 134 3010129 SGTC_1244 0416-0015 52.5 µM 1.25651322870321 0.103045922782542 no 337 0.104464976374573 123 96201 SGTC_954 1189-0853 2.85 µM 1.25235701054819 0.103799214812079 no 338 0.10521990181306 128 2828194 SGTC_2839 9003951 25.97 µM 1.24906176280548 0.104399293595423 no 339 0.105821242336436 108 2990634 SGTC_764 1951-2361 146 µM 1.24569506036828 0.105014976688681 no 340 0.106438183905369 160 5438930 SGTC_2564 betulinic acid 100 µM 1.24563962976328 0.105025135462898 no 341 0.10644836313952 124 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.24510615717397 0.105122941421762 no 342 0.106546365576144 138 676296 Flavone; oxidizing agent. SGTC_2052 5265182 7.135 µM 1.2422462636962 0.105648393444491 no 343 0.107072857531774 127 1239884 SGTC_1851 st056236 18.9 µM 1.24136066158617 0.105811490726522 no 344 0.107236272262319 132 5393171 SGTC_3052 9092717 49.47 µM 1.2404892334388 0.105972155231098 no 345 0.107397247014782 123 25237534 SGTC_1303 1160-0052 261 µM 1.2389321882165 0.106259665160773 no 346 0.107685306041691 116 3562476 SGTC_1941 st076221 61.8 µM 1.23821285662673 0.106392680539448 no 347 0.107818572819175 138 2828568 SGTC_134 0269-0018 6.916 µM 1.23785831090615 0.106458285666339 no 348 0.107884301326046 136 4378915 SGTC_157 1348-1695 65.819 µM 1.23733914557914 0.10655440469077 no 349 0.10798060038515 156 5380510 SGTC_476 mead acid 10 µM 1.23511577482551 0.106966751440153 no 350 0.108393709636768 119 5312531 An omega 9 fatty acid. SGTC_127 0180-0333 59.125 µM 1.23404941453215 0.107164926738516 no 351 0.108592245734068 100 771601 SGTC_1311 1190-0148 100 µM 1.22636961565686 0.108599984511447 no 352 0.110029807358126 150 1961333 SGTC_481 bay k-8644 50 µM 1.22450566402102 0.108950360123122 no 353 0.110380765472238 137 2303 A calcium channel antagonist. SGTC_2046 4110841 106 µM 1.22266253142759 0.109297620587166 no 354 0.110728592188675 156 44119630 YMR134W ERG29 SGTC_302 1094-0063 18.9 µM 1.22172148160855 0.109475227984821 no 355 0.110906484951991 168 5440289 SGTC_3309 9129340 25.759 µM 1.22027590773174 0.109748459445691 no 356 0.111180149826377 130 17158987 SGTC_1356 1502-0781 85.8 µM 1.21815038432902 0.110151098340185 no 357 0.111583415090418 152 567702 SGTC_2139 5578692 56.4705 µM 1.21802336441951 0.110175193290134 no 358 0.111607547059811 150 650991 YMR113W FOL3 SGTC_2354 9060492 162 µM 1.21694441360703 0.110380016544082 no 359 0.1118126828925 150 6471895 SGTC_214 4373-3496 70 µM 1.21564225187178 0.110627576593732 no 360 0.112060615707127 172 3779166 SGTC_2308 7584454 197.62 µM 1.21483565584181 0.110781121783657 no 361 0.112214389336636 145 893577 SGTC_2078 5212016 200 µM 1.21435575105836 0.110872549814406 no 362 0.112305952388497 131 1899708 SGTC_1793 st048256 72.231 µM 1.2134234025717 0.111050328687107 no 363 0.112483991666541 130 672022 SGTC_725 1497-0963 19 µM 1.20819385084107 0.112051276584 no 364 0.113486353246549 137 3549977 SGTC_2711 st079103 59.1 µM 1.20745192293832 0.112193804042865 no 365 0.113629074790471 128 54693780 SGTC_2003 4023581 200 µM 1.20668110440803 0.112342018705542 no 366 0.113777489384807 120 16641307 SGTC_583 1488-1091 88.9 µM 1.20371286035376 0.112914065692292 no 367 0.114350289936715 171 4303273 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.2028412857529 0.113082431829054 no 368 0.114518872409963 142 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2793 7325131 81.82 µM 1.20267923768545 0.113113755151827 no 369 0.114550235707706 139 4176441 SGTC_2769 toremifene 3.73 µM 1.20262102258017 0.11312500943884 no 370 0.114561504336603 151 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1151 3909-8316 15.3 µM 1.20202186885197 0.113240885739132 no 371 0.114677527661854 148 800431 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.19936223445453 0.1137562810714 no 372 0.115193562791191 149 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_469 w7 172 µM 1.19522785748027 0.114560774163663 no 373 0.115999008650691 114 45115570 A P450 inhibitor. SGTC_3315 9136395 68.55 µM 1.19314990455636 0.114966640890648 no 374 0.116405334945478 182 16876844 SGTC_2456 5770359 74.46 µM 1.19210422357353 0.115171270145372 no 375 0.116610190565707 152 3118787 SGTC_3055 9094636 49.47 µM 1.19124254471846 0.115340086536403 no 376 0.116779191018788 176 25236176 SGTC_1691 st019933 84.6 µM 1.19073324825087 0.115439948351986 no 377 0.116879160573282 157 6176082 SGTC_3316 9136639 10.545 µM 1.19051636305015 0.115482493409209 no 378 0.116921751274081 150 4903665 SGTC_1041 0206-0046 107 µM 1.19012916053621 0.115558476281598 no 379 0.116997815280744 142 50494 SGTC_2585 alliin 100 µM 1.18706908988596 0.116160220465287 no 380 0.117600184736301 136 87310 A garlic compound which reacts with lipids. SGTC_198 3454-2873 16.191 µM 1.18590242865731 0.116390221789506 no 381 0.117830416981014 169 710957 SGTC_599 1935-0052 86.5 µM 1.18470380879051 0.116626859877082 no 382 0.118067288010184 120 9557311 SGTC_59 0330-0160 1.33 µM 1.18257323199168 0.117048331792154 no 383 0.11848916319039 139 4293482 SGTC_125 0133-0007 11.75 µM 1.18237236400645 0.117088123212813 no 384 0.118528991916394 142 26541 SGTC_2771 fluoxetine 41.05 µM 1.18142998215363 0.117274934547776 no 385 0.118715976625942 123 3386 A selective serotonin reuptake inhibitor. SGTC_2794 7785382 27.27 µM 1.18002351753261 0.117554134969179 no 386 0.118995430750198 146 2205081 SGTC_698 k064-0052 127 µM 1.17988785621235 0.117581090262431 no 387 0.119022410194211 149 5088751 SGTC_3107 9121808 49.47 µM 1.17851202142678 0.117854709662116 no 388 0.119296271334975 122 662681 SGTC_1178 0988-0033 191 µM 1.17732659927014 0.11809082177576 no 389 0.119532587071874 140 5392207 SGTC_629 3448-6466 76.7 µM 1.17596644484055 0.118362148954238 no 390 0.119804142561713 159 573744 SGTC_1861 st057647 17.4 µM 1.17468340909142 0.118618495947122 no 391 0.120060699694292 147 688668 SGTC_460 trequinsin 123 µM 1.17280492976965 0.118994518152275 no 392 0.12043702038918 152 5537 A vasodilator. SGTC_1219 1469-0211 33.1 µM 1.1721015265978 0.119135537352968 no 393 0.120578148549744 153 6822282 SGTC_1149 3909-7961 23.3 µM 1.17154877954356 0.119246435565804 no 394 0.120689131309008 136 735261 SGTC_486 niguldipine 82 µM 1.17085242893096 0.119386248795115 no 395 0.120829049700378 143 1236 A calcium channel blocker. SGTC_1997 st073024 93.8 µM 1.17075575798138 0.119405667521803 no 396 0.12084848290718 135 686268 SGTC_1828 st055811 49 µM 1.16933922069629 0.119690469331141 no 397 0.121133493564849 130 5877589 SGTC_43 0570-0105 72.5 µM 1.1660122692576 0.120361252294187 no 398 0.12180474245439 142 1114046 YDL195W SEC31 SGTC_362 0310-0100 9.03 µM 1.16541406274502 0.120482143555948 no 399 0.121925713825179 126 790235 SGTC_2976 9009005 19.48 µM 1.16423581651749 0.120720504782629 no 400 0.122164229559817 126 2993148 SGTC_581 0958-0271 211 µM 1.16299969029781 0.120970931842964 no 401 0.122414814038419 125 4591145 SGTC_709 3807-1509 243 µM 1.16097615925352 0.121381667931177 no 402 0.122825797454685 172 1886677 YPL242C IQG1 SGTC_1034 k072-0165 12.7 µM 1.15905514004762 0.121772502537408 no 403 0.123216854922935 169 5835461 SGTC_835 0312-0010 67.2 µM 1.15864198399354 0.121856675238096 no 404 0.123301074032579 159 1626196 SGTC_1061 3448-9325 110 µM 1.15862074198601 0.121861003998251 no 405 0.123305405164223 160 723482 SGTC_555 4296-0685 37 µM 1.15802694057218 0.121982054354315 no 406 0.123426521235736 167 2908540 YHR072W ERG7 SGTC_1516 st013856 110 µM 1.15595998408881 0.12240407567383 no 407 0.123848762597379 144 5281404 A mutagen and neurotoxin. SGTC_2369 9071472 200 µM 1.15532615007856 0.122533693927191 no 408 0.123978445612787 125 17296037 SGTC_2508 celastrol 40.54 µM 1.15467544607002 0.122666862227401 no 409 0.124111679071451 115 122724 Celastrol is a natural product and antioxidant. SGTC_3205 9113483 49.47 µM 1.1543627424091 0.122730893964006 no 410 0.124175741641996 140 17018033 SGTC_804 1595-0054 20.9 µM 1.15268171273191 0.12307551698623 no 411 0.124520525088519 158 761523 Stimulates phospholipase C. SGTC_2080 5212524 12.4 µM 1.15117720984773 0.123384525473061 no 412 0.124829669515472 159 260183 SGTC_1220 1838-0075 193 µM 1.15071344147733 0.123479887940329 no 413 0.124925072429584 139 5529645 SGTC_14 0354-0009 295 µM 1.15023164399554 0.123579012310427 no 414 0.125024238090835 158 1713507 SGTC_1905 st060207 84.5 µM 1.14926812055235 0.12377741346286 no 415 0.125222719591908 169 1948547 SGTC_94 0334-0113 514.748 µM 1.14491495134165 0.124676562905206 no 416 0.126122194927821 146 6795178 SGTC_707 0865-0008 204 µM 1.14333505189158 0.125004018310252 no 417 0.126449753529033 163 723043 SGTC_806 3966-4455 5.86 µM 1.14331756578531 0.125007645899083 no 418 0.126453382214966 137 714982 SGTC_2404 5161160 200 µM 1.14179897284239 0.125322966882646 no 419 0.126768794708807 193 2831543 SGTC_2332 7982454 138.89 µM 1.14154252126884 0.125376271299725 no 420 0.126822113843681 165 2981748 SGTC_2355 9061122 103.12 µM 1.14026441189449 0.125642167086857 no 421 0.127088079806431 160 5302957 SGTC_1351 1496-0003 46.5 µM 1.13899320168122 0.125907017598226 no 422 0.127352994861536 149 3891978 SGTC_1035 k081-0041 55.2 µM 1.13770054522009 0.126176735330442 no 423 0.127622772845034 163 731709 SGTC_1554 st069299 38.7 µM 1.13389148786702 0.126973850643779 no 424 0.128420034057842 132 24207999 SGTC_1008 4106-0037 6 µM 1.13385993098462 0.126980469108174 no 425 0.128426653533178 173 2905394 SGTC_40 0327-0103 19.753 µM 1.13257988603578 0.127249136963751 no 426 0.128695359649569 143 409036 SGTC_2482 5981709 142.65 µM 1.12832755283332 0.128144494479427 no 427 0.129590805696328 173 877755 SGTC_2077 5212015 200 µM 1.12738531266372 0.12834348028019 no 428 0.129789803066536 151 780900 SGTC_1152 3909-8331 15.9 µM 1.12088443539496 0.129722205821543 no 429 0.13116852847569 137 16001939 SGTC_3087 9117406 49.47 µM 1.11912352644703 0.130097423697007 no 430 0.131543722182251 136 42546093 SGTC_1443 4112-3303 14 µM 1.11566931392813 0.130835634114061 no 431 0.132281855160433 171 704433 SGTC_1642 st009582 77.7 µM 1.11541018488442 0.130891129885939 no 432 0.132337343515332 179 6739311 SGTC_752 1896-0090 130 µM 1.11491895042358 0.13099637862136 no 433 0.132442577573377 166 772567 SGTC_1009 4106-0057 9.87 µM 1.1144088067316 0.131105740605048 no 434 0.132551923459293 180 2928005 SGTC_2539 epi(13)torulosol 80 µM 1.11326355231598 0.131351484042127 no 435 0.132797627580052 157 6708597 SGTC_3049 9092223 49.47 µM 1.11178918125133 0.131668315843166 no 436 0.133114402284894 132 8623917 SGTC_396 dithiazanine 1.25 µM 1.11173451207505 0.131680073989751 no 437 0.133126158173943 138 10578 An antihelmenthic. SGTC_2751 anetholtrithion 17.25 µM 1.11135062266634 0.131762660630918 no 438 0.13320872867954 142 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.11021632205821 0.132006893010573 no 439 0.13345291048539 133 77254 SGTC_733 4069-0007 56.1 µM 1.10923354642258 0.132218752019233 no 440 0.133664722172345 165 5717425 YNL287W SEC21 SGTC_2800 7887935 81.82 µM 1.10884831063817 0.132301862021636 no 441 0.133747812736847 160 2961002 SGTC_2438 5259590 200 µM 1.10746334946695 0.132600948186647 no 442 0.134046824883309 164 1201127 SGTC_824 1304-0008 100 µM 1.10669433840108 0.132767219204637 no 443 0.134213052003701 155 768245 SGTC_636 0kpi-0074 126 µM 1.10656758150228 0.132794639608794 no 444 0.134240464980185 154 616434 SGTC_3230 9131665 49.47 µM 1.10588408500511 0.132942562678027 no 445 0.134388347061064 128 15943720 SGTC_106 0092-0003 11.579 µM 1.10534480288696 0.133059354747034 no 446 0.134505105673784 149 1072148 SGTC_2151 5563267 85.4165 µM 1.10289922203408 0.1335898792307 no 447 0.135035466062155 176 5310824 SGTC_620 0109-0052 432 µM 1.101659227192 0.133859428651543 no 448 0.135304924520501 174 493037 SGTC_1723 st034307 2.5525 µM 1.10155888672809 0.133881256945132 no 449 0.135326745224682 179 867466 SGTC_1264 0783-0040 158 µM 1.09980598988665 0.134262980816734 no 450 0.135708330981964 147 2855798 SGTC_325 2810-4341 181 µM 1.09948404267743 0.134333171610566 no 451 0.135778495270577 150 774970 SGTC_2594 a-mangostin 100 µM 1.09773029173866 0.134715966111327 no 452 0.1361611391761 170 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1790 st045711 43.5 µM 1.09605349197307 0.135082663697602 no 453 0.136527682943355 123 585119 SGTC_785 1270-0111 65.3 µM 1.09357594536626 0.135625727620225 no 454 0.137070501959918 159 6741994 SGTC_1791 st048313 56.1 µM 1.0933283960839 0.135680071066749 no 455 0.137124819778582 134 1204976 SGTC_1265 0819-1001 68.8 µM 1.0930846002803 0.135733605104271 no 456 0.137178328371048 169 3106768 SGTC_1349 flufenamic acid 69 µM 1.09280236134151 0.135795598766144 no 457 0.137240292320419 169 3371 A non-steroidal anti-inflammatory. SGTC_76 0433-0009 400.328 µM 1.09272041361975 0.13581360217999 no 458 0.137258287055982 153 2841569 SGTC_1260 0700-1617 7.75 µM 1.09256754689372 0.135847190434251 no 459 0.137291859059913 166 2853078 SGTC_360 0957-0399 1.01 µM 1.08950229641921 0.136521895563753 no 460 0.137966221362281 158 6752301 YPR165W RHO1 SGTC_3314 9135860 59.4275 µM 1.08840054140132 0.136764966469112 no 461 0.138209161128752 154 25252478 SGTC_1055 3448-0672 86 µM 1.08778593109953 0.136900691228954 no 462 0.138344810911242 161 748378 SGTC_123 0083-0120 66.675 µM 1.08727611537557 0.137013343967133 no 463 0.138457400465223 193 16001701 SGTC_64 000l-0018 272.079 µM 1.08645430818248 0.137195070016747 no 464 0.138639022770832 194 6811119 SGTC_554 4483-2211 187 µM 1.08540568573804 0.137427190651619 no 465 0.138871007632931 152 747107 SGTC_1940 st075990 51.1 µM 1.08494862409509 0.137528448619847 no 466 0.138972205229523 162 1084979 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.08354536094415 0.137839647340443 no 467 0.139283214069567 154 803109 SGTC_1354 1498-1681 81 µM 1.08320723121905 0.137914705432994 no 468 0.139358225386313 160 5754243 SGTC_1239 0337-0584 35.4 µM 1.08314709165221 0.137928058143937 no 469 0.139371569736127 188 914301 YML130C ERO1 SGTC_2309 7664088 163.95 µM 1.07581219356421 0.139563231571581 no 470 0.141005628902728 169 704922 SGTC_2138 5575593 77.673 µM 1.07161139916341 0.140505631190659 no 471 0.141947305591497 149 762213 SGTC_192 3455-0609 60.9 µM 1.07107072545795 0.14062723813798 no 472 0.142068814988011 149 3769639 SGTC_2074 5212007 75.395 µM 1.06966059804557 0.140944736423546 no 473 0.142386054008185 164 758611 SGTC_2166 5933061 31.504 µM 1.06900481028954 0.141092556320515 no 474 0.142533750944577 155 2877375 SGTC_260 nsc-65238 3.989 µM 1.06839774411188 0.14122948765015 no 475 0.142670567096563 163 3246252 SGTC_2263 7948595 193.29 µM 1.06676787027256 0.141597571521639 no 476 0.1430383352967 153 2971371 SGTC_1887 st057648 70.8 µM 1.06599743766346 0.141771788812144 no 477 0.143212400102139 184 688672 SGTC_3020 9089140 49.47 µM 1.06318134782951 0.142409823622976 no 478 0.143849859663152 171 17217859 SGTC_287 k060-0039 29.6 µM 1.06265325919118 0.142529687356702 no 479 0.143969612391112 163 5861974 SGTC_1066 ketoconazole 628 nM 1.0595405305729 0.143237589868853 no 480 0.14467684045752 178 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_544 k015-0020 52.4 µM 1.05557738080383 0.144142327791139 no 481 0.145580669704297 179 3008304 SGTC_2149 5554786 194.827 µM 1.05503774464699 0.144265817421925 no 482 0.145704031266195 160 745063 YPR165W RHO1 SGTC_3344 9148862 3.898 µM 1.0543689583964 0.144418960524413 no 483 0.14585701420319 174 4905352 SGTC_1063 disulfiram 1.84 µM 1.05377687498086 0.144554631098854 no 484 0.145992541644833 181 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1856 st057054 55.7 µM 1.05355855040187 0.144604679869061 no 485 0.146042537319377 187 1266018 SGTC_389 tpck 16.7 µM 1.05303603261813 0.144724509346631 no 486 0.146162239028997 147 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1845 st056753 3.01 µM 1.05290646907786 0.144754232615563 no 487 0.146191930465132 152 5375839 SGTC_805 3852-0218 479 µM 1.05269908754117 0.144801816725491 no 488 0.146239463497666 167 6615355 SGTC_1660 st012960 28.1 µM 1.05222237969002 0.144911238231281 no 489 0.146348767006974 165 24207266 SGTC_753 1322-0200 289 µM 1.05144572235227 0.145089628078745 no 490 0.146526962866601 159 5403907 SGTC_703 3875-0075 71.8 µM 1.0491355120367 0.145621131968104 no 491 0.147057876917017 195 2850814 SGTC_499 genistein 192 µM 1.04898635812577 0.145655492339805 no 492 0.14709219854731 163 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_488 nitrendipine 139 µM 1.04544225624758 0.146473545614169 no 493 0.147909307687754 158 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3209 9113616 49.47 µM 1.04501610945013 0.14657211657374 no 494 0.148007762071037 181 16649353 SGTC_2812 7970281 58.44 µM 1.0445144292228 0.146688216027907 no 495 0.148123723445062 179 2233435 SGTC_1647 st011722 22.4 µM 1.04397780335691 0.146812470931211 no 496 0.148247829642783 174 2854783 SGTC_854 0422-0053 192 µM 1.04316353971013 0.14700114725909 no 497 0.148436278338761 194 3596728 SGTC_2325 6158266 200 µM 1.04304008392152 0.147029767889543 no 498 0.148464864246986 156 3623240 SGTC_1508 1080-0625 72.9 µM 1.04219096242028 0.147226720096258 no 499 0.148661576141108 162 767111 SGTC_1218 1348-1416 30.7 µM 1.03977137039867 0.147788909682813 no 500 0.149223066616709 174 6787668 SGTC_3225 9130819 49.47 µM 1.0382981953838 0.148131903429694 no 501 0.149565624298883 184 4547121 SGTC_1569 carminic acid 40.6 µM 1.03712506452759 0.148405419725751 no 502 0.149838787700548 168 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_782 0083-0095 30.5 µM 1.03668028304033 0.148509209099445 no 503 0.149942441968196 168 3591729 An indicator and reagent. SGTC_2511 berberine 10.47 µM 1.03449069070097 0.149020856048249 no 504 0.150453413301809 188 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_818 4072-2707 53.5 µM 1.03353391454928 0.149244797338227 no 505 0.150677053881061 161 882871 SGTC_3275 9138069 49.47 µM 1.03297114932795 0.14937662205024 no 506 0.150808700156986 200 17617007 SGTC_386 1509-0011 3.07 µM 1.0327321898817 0.149432620512466 no 507 0.150864622502313 165 3107280 SGTC_1703 st026983 48.3 µM 1.03107122191193 0.149822243822825 no 508 0.151253710967486 161 1104023 SGTC_833 3852-0053 558 µM 1.02955066452088 0.15017952375578 no 509 0.151610492415589 193 3123681 SGTC_1572 epiandrosterone 68.9 µM 1.02814284164786 0.150510820763651 no 510 0.151941320341648 159 441302 A steroid. SGTC_2316 5844804 197.44 µM 1.02520579192852 0.15120355042673 no 511 0.152633047964485 194 776813 SGTC_1699 st031318 29.054 µM 1.02444623393266 0.151383043666361 no 512 0.152812276902027 187 5340658 SGTC_3329 9141233 27.5565 µM 1.02245090193739 0.151855240847492 no 513 0.15328376964859 175 4909101 YNL103W MET4 SGTC_3058 9093861 49.47 µM 1.0208050596936 0.152245466675878 no 514 0.153673403377271 184 17217477 SGTC_1641 st009299 47.1 µM 1.01923835048602 0.152617548190045 no 515 0.154044911966372 173 4046054 SGTC_2624 nerol 100 µM 1.01769876779972 0.152983774590996 no 516 0.154410566519307 189 637566 A natural product oil. SGTC_2394 5221648 200 µM 1.01693598783867 0.153165435623954 no 517 0.154591940981704 197 788586 SGTC_504 lovastatin 124 µM 1.01499781303015 0.153627667499746 no 518 0.155053434998561 184 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_424 splitomicin 100 mM 1.01475450652546 0.153685758421123 no 519 0.15511143230923 180 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2281 7943571 200 µM 1.01357710603477 0.153967075455589 no 520 0.155392293240548 190 1244024 SGTC_903 1134-0042 114 µM 1.01172145670453 0.154411138185119 no 521 0.155835626667609 182 701009 SGTC_1792 st045773 43.6 µM 1.01036107069011 0.154737220224829 no 522 0.156161165912581 103 2919270 SGTC_1174 0739-0097 51.1 µM 1.00974349054777 0.154885403103828 no 523 0.156309100101819 194 728447 SGTC_3292 9120825 59.784 µM 1.00913090794406 0.155032479435222 no 524 0.156455928351474 186 24824900 SGTC_2747 doxorubicin 7.63 µM 1.00789178443095 0.155330265235878 no 525 0.156753208056862 119 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1115 galangin 695.678 nM 1.00778559256509 0.155355802783594 no 526 0.156778701966068 201 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2611 pyromycin 23.93 µM 1.00736171350616 0.155457766928084 no 527 0.156880491502159 173 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3242 9133940 49.47 µM 1.00365914985593 0.156350295880305 no 528 0.157771466704788 161 17248444 SGTC_617 3770-0098 35 µM 1.00282623147634 0.156551540804954 no 529 0.15797235503297 180 5962639 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.00105326748747 0.156980481741517 no 530 0.158400528252198 172 2374 Ca(2+)-ATPase inhibitor. SGTC_615 k087-0205 167 µM 1.00054552468597 0.157103464454034 no 531 0.158523288932851 204 9642773 SGTC_2717 st081029 62.2815 µM 1.0001264848109 0.157205009738716 no 532 0.158624650245697 179 5292846 SGTC_2977 9011197 71.43 µM 0.998099910498394 0.157696715297705 no 533 0.159115456762856 198 2704722 SGTC_2089 5281248 129.67 µM 0.998084228474185 0.157700524145438 no 534 0.159119258593422 168 2737878 SGTC_872 0588-0139 234 µM 0.99752709567175 0.157835879689224 no 535 0.159254364239116 157 2047100 SGTC_755 1995-0008 37.3 µM 0.995720080764501 0.158275419273007 no 536 0.159693085257601 150 689533 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.993338022775872 0.158856058788812 no 537 0.160272626912491 180 688761 SGTC_441 propafenone 146 µM 0.98937058120863 0.159826239307293 no 538 0.161240931315638 209 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2605 digitonin 300 nM 0.988826524120651 0.159959582184259 no 539 0.161374012277068 205 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1391 3442-0225 151 µM 0.988792829579827 0.159967842766452 no 540 0.161382256601444 172 5227075 SGTC_1795 st049545 62.3 µM 0.988597013046799 0.160015854835454 no 541 0.161430174102678 162 5291882 SGTC_1119 parthenolide 318.541 nM 0.988505316514536 0.160038341059935 no 542 0.161452615993235 210 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_44 0929-0055 61.211 µM 0.988446163465784 0.160052847925469 no 543 0.161467094242236 205 1379590 SGTC_1802 st050112 57.9 µM 0.988352545917689 0.160075808722149 no 544 0.161490009722361 168 4662563 SGTC_1777 st045864 34.765 µM 0.988069577900984 0.1601452230245 no 545 0.161559286849179 223 4691462 SGTC_931 2812-0076 566 µM 0.987738206887604 0.160226535978182 no 546 0.161640438777035 176 3450959 SGTC_885 0865-0106 16.8 µM 0.985482232767599 0.160780831771015 no 547 0.162193627237045 177 2793380 SGTC_248 streptozotocin 5.23457 mM 0.985111987685291 0.160871920933987 no 548 0.162284532821996 199 5300 DNA alkylating agent. SGTC_1820 st053765 18.6 µM 0.982780976528877 0.161446179121414 no 549 0.162857623264677 190 3690829 SGTC_268 camptothecin 39.6153 µM 0.980017069250869 0.162128813764478 no 550 0.163538846509817 222 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1987 st072290 61.9 µM 0.979300778878013 0.162306030642603 no 551 0.163715692863201 192 54697379 SGTC_1988 st071872 53.4 µM 0.979101698898869 0.162355307260366 no 552 0.163764866152854 169 16414116 SGTC_3034 9090421 49.47 µM 0.977925645755026 0.162646604608161 no 553 0.164055550011049 169 17173761 SGTC_2175 5807670 165.306 µM 0.976898192529636 0.16290137324607 no 554 0.164309778355633 157 241186 SGTC_706 4262-0057 46.9 µM 0.976488458335916 0.163003043800547 no 555 0.164411232323997 188 883298 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.975780950476415 0.16317870035721 no 556 0.16458651338063 207 442882 SGTC_1755 st041960 45.185 µM 0.975096889171204 0.163348652638902 no 557 0.164756100786677 205 2257073 SGTC_101 0490-5701 117.494 µM 0.974487837729874 0.163500065752751 no 558 0.164907187528762 169 4661669 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.972789662458834 0.163922721489457 no 559 0.165328925768372 174 2724 A muscle relaxant with antifungal properties. SGTC_741 4582-0002 126 µM 0.972126900250531 0.164087867332148 no 560 0.165493710534884 199 2912688 SGTC_2934 9036370 36.88 µM 0.970887397553903 0.164397013845564 no 561 0.165802177242348 166 6462800 SGTC_1147 3809-1045 12.3 µM 0.968882375972763 0.164897888592389 no 562 0.166301939856215 177 325925 SGTC_750 4073-0104 132 µM 0.968314134263553 0.16504002068873 no 563 0.166443753956734 158 22330957 SGTC_595 3909-8003 73.7 µM 0.965932662466944 0.165636551483981 no 564 0.167038938548177 196 699517 SGTC_1442 4112-3290 3 µM 0.965214484283234 0.165816720009441 no 565 0.167218696818831 189 704353 SGTC_693 4161-2696 114 µM 0.964138401961713 0.166086912553613 no 566 0.167488270940963 214 805759 SGTC_2809 7964133 12.99 µM 0.962149674847717 0.16658700843999 no 567 0.167987212168021 205 1253665 SGTC_3056 9094900 49.47 µM 0.957490337437305 0.167762471841928 no 568 0.169159910575971 206 25236784 SGTC_1350 1495-0454 146 µM 0.957194275865757 0.167837342650922 no 569 0.169234602857841 180 1069057 SGTC_3234 9132280 49.47 µM 0.955797012900703 0.168190985820463 no 570 0.169587398890262 187 17612295 SGTC_1882 5615643 20 µM 0.955522851840534 0.168260431402158 no 571 0.169656677365677 179 2253075 SGTC_1305 1181-0477 144 µM 0.953956089244539 0.168657649541484 no 572 0.170052934947158 210 6252086 SGTC_1418 3966-3099 2.4 µM 0.953213388155164 0.168846155442486 no 573 0.170240982185533 204 740335 SGTC_787 4152-0075 138 µM 0.95166939724766 0.169238470765838 no 574 0.170632337154027 183 9566539 SGTC_1991 st073000 8.92 µM 0.951475340435001 0.169287820362819 no 575 0.170681565394148 211 4301969 YIL048W NEO1 SGTC_2044 5102272 200 µM 0.951337268394521 0.16932293838217 no 576 0.170716596978691 196 592666 SGTC_1146 3579-1023 7 µM 0.950369159657715 0.169569303931066 no 577 0.17096235440023 224 X1146 SGTC_1559 coumarin 343 70.1 µM 0.949435547173551 0.169807108546805 no 578 0.171199569109117 185 108770 A hepatotoxic, DNA x-linker. SGTC_2311 7694451 200 µM 0.949052490892326 0.16990474036986 no 579 0.171296957916403 228 2163142 SGTC_2103 5378138 10 µM 0.948381543569681 0.170075835394416 no 580 0.171467625908694 196 244142 SGTC_3278 9139605 49.47 µM 0.947779632601928 0.170229419724387 no 581 0.171620825655529 201 7958859 SGTC_2746 daunorubicin 9.88 µM 0.946405511099404 0.170580375103256 no 582 0.171970897774521 158 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3015 9080845 49.47 µM 0.945937678802671 0.170699966720416 no 583 0.172090187000377 195 5296973 SGTC_771 0250-0039 27.3 µM 0.944863353947683 0.17097479864489 no 584 0.172364321290126 215 3005115 SGTC_659 k018-0002 107 µM 0.943393665607247 0.171351230004405 no 585 0.17273979099162 195 6797879 YHR007C ERG11 SGTC_1700 st030840 7.9285 µM 0.941409088236024 0.171860379954421 no 586 0.173247629007348 218 5499307 SGTC_2226 7298446 200 µM 0.94081509506292 0.172012958545335 no 587 0.173399811940805 180 3283010 SGTC_300 r073-0011 5.04 µM 0.939646372551315 0.172313419813452 no 588 0.173699490701915 188 2735780 SGTC_2623 humulene 100 µM 0.937404362826602 0.172890743978526 no 589 0.174275298804571 175 6187145 An anti-inflammatory. SGTC_53 0973-0023 39.979 µM 0.937124259396387 0.172962957961708 no 590 0.174347321998176 204 674768 SGTC_2963 9082507 9 µM 0.935453997125239 0.173393970253476 no 591 0.174777190231793 198 16459611 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.935419032189525 0.173403000278553 no 592 0.174786196190644 209 756377 SGTC_2050 5263056 171 µM 0.934739576865928 0.173578535464442 no 593 0.174961262759314 198 763468 YGL055W OLE1 SGTC_1985 st071382 65.5 µM 0.934102480269122 0.173743230085423 no 594 0.175125516334318 204 6123237 SGTC_49 0717-0965 32.132 µM 0.933888959252474 0.173798449227362 no 595 0.175180587305071 207 5889349 YGL099W LSG1 SGTC_743 1275-0778 158 µM 0.933583166447524 0.173877550418612 no 596 0.175259475982591 226 2849257 YMR203W TOM40 SGTC_3150 9097574 49.47 µM 0.933187280443934 0.173979990538962 no 597 0.175361640433456 176 17217476 SGTC_1971 st069429 63.5 µM 0.931798338879296 0.174339698773257 no 598 0.175720376636546 186 1246522 YGL099W LSG1 SGTC_147 4466-0538 29.23 µM 0.9270014379644 0.175585631282371 no 599 0.176962893842277 214 6742687 YHR072W ERG7 SGTC_579 4491-1009 110 µM 0.925840693544913 0.175887965355233 no 600 0.177264387892639 243 1271041 SGTC_2125 5246583 200 µM 0.925089979925646 0.176083675940469 no 601 0.177459552367754 215 835267 SGTC_2670 beta-carotene 100 µM 0.921639836951647 0.176984897858723 no 602 0.178358235915281 163 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2955 9076254 12.21 µM 0.921501388939565 0.177021122989493 no 603 0.178394358206515 189 16459619 SGTC_3065 9113888 49.47 µM 0.917984525160048 0.177942886246301 no 604 0.179313483760811 197 16648368 SGTC_1563 conessine 56.1 µM 0.917488213796104 0.178073211791726 no 605 0.179443433132091 183 441082 An anti-amoebic, histamine inhibitor. SGTC_2060 5238662 140 µM 0.917451821053293 0.178082770466797 no 606 0.179452964185348 212 790130 SGTC_2882 9058044 58.44 µM 0.917152615066404 0.17816137017732 no 607 0.1795313366024 215 18076804 SGTC_303 1348-1668 34.2 µM 0.914908977673553 0.178751457544621 no 608 0.180119708300053 199 5380509 SGTC_505 gw-5074 63.9 µM 0.914693818727424 0.178808109959985 no 609 0.180176195140959 214 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3272 9137413 49.47 µM 0.914124521157664 0.178958063337221 no 610 0.180325709534591 211 17614870 SGTC_432 NS 1619 61.3 µM 0.913169672348717 0.17920974879648 no 611 0.18057665583271 185 4552 A K+/calcium channel activator. SGTC_2076 5212012 200 µM 0.913089616567268 0.17923086054736 no 612 0.180597705447344 191 604802 SGTC_908 3448-7491 47.7 µM 0.909724968135352 0.180119576150653 no 613 0.181483786580991 182 1203031 SGTC_2021 4019055 173 µM 0.909246327607879 0.180246225420121 no 614 0.181610057436216 233 44827708 YER133W GLC7 SGTC_496 calpeptin 138 µM 0.908912111127435 0.180334692918113 no 615 0.181698260163181 188 73364 A calpain inhibitor. SGTC_613 3914-0030 117 µM 0.907894491157622 0.180604225864628 no 616 0.181966984207986 177 1145395 SGTC_120 rhodamine 6G 52.259 µM 0.907804182707751 0.18062815770273 no 617 0.181990844061781 248 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2073 5212005 126 µM 0.906819644544153 0.180889190397699 no 618 0.182251089887308 218 691789 SGTC_2367 9070478 135.38 µM 0.905987322238653 0.18111005010398 no 619 0.182471281377233 208 572802 SGTC_1889 st059080 5.18 µM 0.905143598430314 0.181334107579783 no 620 0.182694658674934 184 176925 Isolated from Daphnopsis sellowiana. SGTC_2479 5617353 43.85 µM 0.904156924002707 0.181596346776475 no 621 0.182956098864382 207 2731746 SGTC_723 4182-0001 115 µM 0.902001847833791 0.182169949618654 no 622 0.183527943071776 188 744821 YLR208W SEC13 SGTC_2902 5787006 60.46 µM 0.901949827149963 0.18218380961516 no 623 0.183541760388857 209 591003 SGTC_3161 9100388 49.47 µM 0.899495086723944 0.182838581263873 no 624 0.184194505846699 221 25236368 SGTC_3273 9137859 49.47 µM 0.898157606729784 0.183195954905409 no 625 0.184550765408979 231 2377234 SGTC_1726 st035556 14.5795 µM 0.898087524153969 0.183214692921162 no 626 0.184569444851651 174 5919439 SGTC_1687 st020778 55.3625 µM 0.896908023557609 0.183530235957 no 627 0.1848839991569 199 4259299 SGTC_951 1171-0579 82.7 µM 0.896671123909798 0.183593652782947 no 628 0.184947216730202 216 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1489 4065-0444 182 µM 0.89664264794295 0.183601276573125 no 629 0.184954816554621 206 2877968 SGTC_2671 danthron 100 µM 0.894938924400539 0.184057768621196 no 630 0.185409868842364 208 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_324 1315-0088 19.6 µM 0.894337635384034 0.184219045266624 no 631 0.185570634594445 224 6787421 SGTC_2288 7946289 167.31 µM 0.891751891602856 0.184913590585113 no 632 0.186262966456987 214 1246052 SGTC_471 1-acyl-paf 4 µM 0.891629483609126 0.184946510350776 no 633 0.186295780776862 190 16759367 SGTC_1588 farnesol 29.9 µM 0.891489493561046 0.184984163005782 no 634 0.18633331276704 205 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3313 9133968 57.047 µM 0.890606242475461 0.185221837908842 no 635 0.186570224544272 210 1494643 SGTC_1942 st076330 65.2 µM 0.890398226352466 0.185277840750957 no 636 0.186626047207767 218 24208414 SGTC_680 0417-1641 114 µM 0.887430649212644 0.186077927027508 no 637 0.187423544207039 203 2835990 SGTC_738 1315-0003 72.4 µM 0.887186955842616 0.186143724039521 no 638 0.187489127026654 227 6251474 SGTC_2081 5214970 32.255 µM 0.885801269837352 0.186518132193377 no 639 0.187862312726388 178 2063512 SGTC_122 0236-0016 402.397 µM 0.884608701476065 0.186840733683428 no 640 0.188183855978803 227 6808838 SGTC_174 3553-0389 74.3 µM 0.884400401347537 0.18689711632422 no 641 0.188240053198324 203 738071 SGTC_2948 9070189 9.45 µM 0.883473763062585 0.187148066181964 no 642 0.188490176090584 191 6473636 YDL196W YDL196W SGTC_2907 7721985 69.9 µM 0.882861587098681 0.187313968400489 no 643 0.188655530094861 190 3267881 SGTC_68 0986-0284 82.829 µM 0.880363009822857 0.187992035595273 no 644 0.189331344199877 213 423278 YIL048W NEO1 SGTC_1144 3486-0183 12.5 µM 0.879717457692639 0.188167472411305 no 645 0.189506194822225 231 6744069 SGTC_447 ml7 120 µM 0.876365962087028 0.189079905927259 no 646 0.190415558147481 221 4216 Selective myosin light chain kinase inhibitor. SGTC_75 0159-0059 199.013 µM 0.876285043079407 0.18910196949495 no 647 0.190437547030801 226 5377270 SGTC_1579 chlormadinone acetate 49.4 µM 0.876256586533575 0.189109728900763 no 648 0.190445280166337 211 45114258 A steroidal progestin. SGTC_163 TUB2.036 7.546 µM 0.875837454388898 0.189224038723317 no 649 0.190559202681455 242 15992207 YJR013W GPI14 SGTC_926 2268-1401 59.4 µM 0.875639555898444 0.189278026320006 no 650 0.190613007160993 236 2931578 SGTC_2669 eugenol 100 µM 0.874511347357691 0.189585987769272 no 651 0.190919921665813 194 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_904 1141-0088 396 µM 0.873991975119084 0.189727861774816 no 652 0.19106131199098 201 1378119 SGTC_2295 7971645 200 µM 0.872614077808913 0.190104570565691 no 653 0.191436732324595 194 2978226 YKL099C UTP11 SGTC_2745 rifampicin 24.3 µM 0.872418657643421 0.190158034449857 no 654 0.191490012855776 159 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2764 methyldopa 94.69 µM 0.870891813678847 0.190576072964294 no 655 0.191906613524588 210 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2843 9000894 45.46 µM 0.870736220905688 0.190618704760338 no 656 0.191949098271099 149 2242070 SGTC_899 1083-0020 478 µM 0.868420774717088 0.191253819311296 no 657 0.192582013008107 236 767123 SGTC_2848 9016370 25.97 µM 0.868173332768496 0.191321767953547 no 658 0.192649725290193 203 7894410 SGTC_2811 7967822 32.47 µM 0.861989952050727 0.193024552710258 no 659 0.194346523561563 199 2232244 SGTC_2941 9056145 11.23 µM 0.859098968944476 0.193823838976046 no 660 0.195142958061113 206 2119517 SGTC_132 0417-1715 25.805 µM 0.858813711321243 0.193902814952427 no 661 0.19522165082313 214 6769098 SGTC_2207 7258803 200 µM 0.85729330778756 0.194324082223544 no 662 0.195641403045333 227 3666799 SGTC_2285 7945142 200 µM 0.856679364521953 0.194494348972231 no 663 0.195811055370199 217 2970608 SGTC_1491 4138-0063 26.5 µM 0.856393208248565 0.194573740575336 no 664 0.195890160073483 219 23883227 SGTC_2588 indole-3-carbinol 100 µM 0.85639016779705 0.194574584228396 no 665 0.195891000676417 219 3712 Induces cell cycle arrest. SGTC_814 3342-0569 96 µM 0.855041977204551 0.194948894395661 no 666 0.196263954688009 223 4346283 SGTC_433 pimozide 108 µM 0.854404665148573 0.19512598932385 no 667 0.196440405985564 205 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_957 1187-1561 14.1 µM 0.852950410164876 0.195530460598361 no 668 0.196843402447873 229 1538454 SGTC_2426 5582046 32.21 µM 0.852501099196444 0.195655530133911 no 669 0.196968014594453 209 2251934 SGTC_1145 3546-0597 10.2 µM 0.852097644197844 0.195767876644995 no 670 0.197079949702316 225 875334 SGTC_710 3448-4187 58 µM 0.850523852572963 0.196206490470231 no 671 0.197516952447834 219 3946412 SGTC_1053 3366-3204 134 µM 0.849165377263254 0.196585574649869 no 672 0.197894637919881 242 3632071 YPR165W RHO1 SGTC_381 3461-2219 42.7 µM 0.84840762246122 0.196797219698089 no 673 0.198105499532108 219 2883159 SGTC_1969 st069479 40.1 µM 0.847172564854021 0.197142473608118 no 674 0.198449471553515 224 3895485 SGTC_2270 7924575 90.91 µM 0.846112703620897 0.197439044299543 no 675 0.198744937279876 226 1262135 SGTC_1135 dihydrocapsaicin 536.708 nM 0.845439109467983 0.197627669758188 no 676 0.198932858118293 231 107982 A Capsaicinoid. SGTC_605 1315-0399 119 µM 0.844724554659723 0.197827884376738 no 677 0.199132323263884 235 24020461 SGTC_966 1300-0360 30.2 µM 0.843872990452522 0.198066648311335 no 678 0.199370191324199 235 70588 SGTC_3287 9117173 37.0625 µM 0.842451660521346 0.198465552135578 no 679 0.199767593328022 188 2789709 SGTC_989 1501-0895 10.3 µM 0.841274058493796 0.198796419289487 no 680 0.200097210001115 215 2830112 SGTC_3312 9133330 71.43 µM 0.840196398560677 0.199099497240372 no 681 0.200399138681294 233 17617324 SGTC_2866 9034245 58.44 µM 0.839764098060222 0.199221154368383 no 682 0.200520333461494 212 6462273 SGTC_1420 4'-methoxyflavone 42 µM 0.839568051390872 0.199276340176398 no 683 0.200575309347213 217 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1355 1499-0035 1.68 µM 0.838452710991787 0.199590476069008 no 684 0.200888247998653 229 1548538 SGTC_1558 st069300 45.6 µM 0.838004705897116 0.199716740657796 no 685 0.201014030267209 227 24208000 SGTC_721 1187-1332 279 µM 0.837653154927981 0.19981585450932 no 686 0.201112765071598 223 25730 SGTC_1927 st060202 13.8 µM 0.837565288710499 0.199840631524282 no 687 0.201137447269827 231 688887 SGTC_1503 4585-0012 61.3 µM 0.836248102352657 0.200212280652104 no 688 0.201507671270669 211 2922052 SGTC_186 3455-3465 67.277 µM 0.836164847831907 0.200235785178955 no 689 0.201531085484413 226 755278 SGTC_1841 st054148 70 µM 0.834104838639079 0.200817897677486 no 690 0.202110954379142 225 675442 SGTC_3073 9114972 49.47 µM 0.8336429821406 0.200948547226531 no 691 0.202241098550753 205 41905075 SGTC_1060 3448-7350 82 µM 0.83276139715858 0.201198070715913 no 692 0.202489654984124 220 570178 SGTC_930 2810-3379 265 µM 0.832332506406029 0.201319530945571 no 693 0.202610643602895 228 1015764 SGTC_2090 5301565 104.445 µM 0.832319962469227 0.201323084002201 no 694 0.202614182854918 228 2056344 SGTC_2899 9053889 58.44 µM 0.831925602005954 0.201434805346127 no 695 0.202725469879944 212 6470052 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.831899302782327 0.201442257172434 no 696 0.202732892719856 224 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1888 azatryptophan 97.5 µM 0.831502538435131 0.201554699510254 no 697 0.202844897413131 187 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2439 5492030 7.2 µM 0.831281986695198 0.2016172197544 no 698 0.202907174105382 225 5722370 SGTC_111 0083-0039 52.457 µM 0.829013496414037 0.202260947255793 no 699 0.203548385107083 195 759313 SGTC_3118 9124250 49.47 µM 0.825810097054562 0.203172064034494 no 700 0.204455912740787 216 1504786 SGTC_1122 capsaicin 818.572 nM 0.825427878253682 0.203280938777429 no 701 0.204564356460955 226 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2998 9066762 71.4286 µM 0.822917628996092 0.203996846256154 no 702 0.205277418445644 211 4945196 SGTC_1627 st003713 25.6 µM 0.821251863636909 0.204472740255437 no 703 0.205751410110208 238 16195070 YER133W GLC7 SGTC_508 roscovitine 141 µM 0.820939252256311 0.204562124060913 no 704 0.205840435653463 252 160355 A CDKinase inhibitor. SGTC_2254 7938975 95.19 µM 0.818682961690636 0.205207946008387 no 705 0.206483660066571 234 2969277 SGTC_1669 st015249 58.4 µM 0.817657990704636 0.205501724943799 no 706 0.206776252191204 245 722793 SGTC_2938 9059746 27.26 µM 0.816104565878099 0.20594744595718 no 707 0.207220166373153 218 6471769 SGTC_2618 avocadyne 43.43 µM 0.815699065420065 0.20606388968658 no 708 0.207336136842166 231 3015189 SGTC_652 0437-0092 114 µM 0.813885821935394 0.206585059075942 no 709 0.207855181828704 224 3091274 SGTC_870 0573-2213 57.6 µM 0.813623802051718 0.206660434340154 no 710 0.207930249006124 227 3916321 SGTC_1722 st034304 3.6505 µM 0.812554543993602 0.206968196616256 no 711 0.208236751144565 226 4036148 YLR033W RSC58 SGTC_840 0245-0196 390 µM 0.811629551754942 0.207234653837031 no 712 0.208502114503976 215 3827528 SGTC_202 3594-0513 34.79 µM 0.810549343803871 0.207546079816004 no 713 0.208812258673665 232 708429 SGTC_2303 7774051 200 µM 0.807429556855672 0.208447071748027 no 714 0.209709521974511 249 2953184 SGTC_406 estrone 100 µM 0.80722200042624 0.208507095599117 no 715 0.209769296361711 228 5870 A steroid. SGTC_2616 abietic acid 100 µM 0.806909739600409 0.208597418419004 no 716 0.209859243543128 243 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2813 7971799 71.43 µM 0.806373844284822 0.208752482250721 no 717 0.210013661789658 219 2234054 SGTC_295 k015-0027 31 µM 0.806111000614134 0.208828562127119 no 718 0.210089424596045 225 3887424 SGTC_2894 9048625 32.47 µM 0.805647422359109 0.208962784267622 no 719 0.210223086835615 252 4092861 SGTC_1813 st051246 8.6015 µM 0.805636443243962 0.208965963721843 no 720 0.210226253018896 216 5291959 SGTC_2748 diazoxide 86.69 µM 0.80493813274209 0.209168246777375 no 721 0.210427690990444 179 3019 A potassium channel activatior. SGTC_932 2857-0803 154 µM 0.804447932720719 0.209310314284411 no 722 0.210569164082874 226 674898 SGTC_2472 5377652 49.4 µM 0.804135673657074 0.209400841367193 no 723 0.210659312012949 248 1610903 SGTC_838 0109-0203 71.4 µM 0.803443216180347 0.209601674016228 no 724 0.210859302450782 222 759422 SGTC_1720 st037298 9.481 µM 0.802440830231671 0.209892595467988 no 725 0.211149001288112 234 597396 SGTC_330 1488-0319 80.1 µM 0.79979400171864 0.210661921595762 no 726 0.211915079462496 246 6846614 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.799767210998717 0.210669717023714 no 727 0.211922841869862 241 688798 SGTC_2980 9014342 25.29 µM 0.798702736837542 0.210979589249862 no 728 0.212231399733064 247 2996599 SGTC_455 paf C-16 10 µM 0.798241647897064 0.211113896782918 no 729 0.212365136507268 215 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.797303585273979 0.211387293429238 no 730 0.212637369308933 243 5024745 SGTC_2176 5809774 33.9695 µM 0.797264673736333 0.211398638603648 no 731 0.212648666129038 210 2870539 SGTC_36 0335-0881 14.2 µM 0.795407645226921 0.211940494380127 no 732 0.213188207080647 237 23828853 SGTC_879 0831-1030 162 µM 0.794570823967743 0.212184932780886 no 733 0.213431597790796 248 1549252 SGTC_1383 3049-0032 20.7 µM 0.792000895038386 0.212936647455905 no 734 0.214180077175174 250 712864 SGTC_1064 honokiol 6.76 µM 0.791763650374335 0.213006120754416 no 735 0.214249250454104 240 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2715 st079500 56.4 µM 0.791628515018237 0.213045698889431 no 736 0.214288657594836 250 28246688 SGTC_2161 5662504 8.5105 µM 0.791180700111391 0.213176884560304 no 737 0.214419276090813 224 2859334 SGTC_2057 5236571 38.335 µM 0.790944881447635 0.213245985672242 no 738 0.21448807820213 218 54684039 YBR257W POP4 SGTC_2953 9074162 66.49 µM 0.790794131483835 0.213290166245756 no 739 0.214532067517581 227 16451992 SGTC_2513 baicalein 25.65 µM 0.790540423720768 0.213364532902012 no 740 0.214606112083894 240 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_760 0568-0725 82.9 µM 0.78979985385573 0.213581694703459 no 741 0.21482233221448 253 3916171 SGTC_3169 9102970 49.47 µM 0.788771956239488 0.213883324694639 no 742 0.215122651494724 245 17027839 SGTC_317 4495-0002 170 µM 0.78867035577256 0.213913152166188 no 743 0.21515234917883 221 15991618 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.787876051094126 0.214146424519364 no 744 0.215384605419739 214 6708630 An antioxidant. SGTC_48 0382-0018 55 µM 0.786007472546245 0.214695774245137 no 745 0.215931554675105 218 762596 SGTC_541 4513-1321 94 µM 0.785854270313853 0.214740850983289 no 746 0.215976433973494 244 747515 SGTC_1502 4534-4282 27.7 µM 0.785784166975639 0.214761479343023 no 747 0.215996971955613 255 3278949 SGTC_395 anisomycin 6.25 µM 0.783258886542965 0.215505326827879 no 748 0.216737550538627 249 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2944 9067346 25.62 µM 0.781842826255891 0.215923095119338 no 749 0.217153474459887 253 6473075 SGTC_924 2046-0044 21.3 µM 0.780502178158022 0.216319047279476 no 750 0.2175476729757 238 3623589 SGTC_1650 st011916 45.8 µM 0.778208097445772 0.216997563957337 no 751 0.218223171955042 262 242528 SGTC_2329 6138490 200 µM 0.77373198881021 0.218324990913862 no 752 0.219544649471898 243 720019 SGTC_1376 2910-0861 41.3 µM 0.773722804457618 0.218327719409704 no 753 0.219547365676816 254 1112859 SGTC_1675 st018485 24.5 µM 0.772598138319819 0.218661984705816 no 754 0.21988012330861 266 3323024 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.770598586829198 0.219257004089862 no 755 0.220472449547633 212 4000243 SGTC_484 loperamide 105 µM 0.76755031213492 0.220165887220079 no 756 0.221377195862867 211 3955 An opioid-receptor agonist. SGTC_1120 ficusin 1.78878 µM 0.76645127408493 0.220494109060327 no 757 0.221703916966843 244 6199 A DNA cross-linker. SGTC_1242 0402-0103 60.1 µM 0.76605311091195 0.220613087522476 no 758 0.221822350530184 245 432868 SGTC_307 1501-1223 22.3 µM 0.765457836359863 0.220791035062045 no 759 0.22199948222053 241 2830329 SGTC_2245 6637752 200 µM 0.765166616711895 0.220878120319722 no 760 0.222086167826574 237 681890 SGTC_1973 st070275 50.2 µM 0.76493551315761 0.220947242673506 no 761 0.222154972783928 228 17118334 SGTC_2380 9035439 200 µM 0.763722184523432 0.221310348585888 no 762 0.22251640876944 236 6462575 SGTC_280 3448-3607 3.04 µM 0.762273120425673 0.221744448545227 no 763 0.222948506546577 225 626179 SGTC_1715 st032160 10.2275 µM 0.762026717228731 0.221818312563888 no 764 0.223022029262785 226 5289825 SGTC_3075 9116269 49.47 µM 0.761817370656673 0.221881079199461 no 765 0.223084505731396 242 17015205 YNL244C SUI1 SGTC_909 3448-9333 149 µM 0.761172829481149 0.222074390278325 no 766 0.223276922323814 239 3344074 SGTC_1323 1348-1351 11.2 µM 0.757625901897113 0.223139905104747 no 767 0.224337484694753 247 6989654 SGTC_1743 st037606 46.3785 µM 0.757019539364108 0.223322350337905 no 768 0.224519078191588 214 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1875 nocodazole 6 µM 0.754685664317667 0.224025369387723 no 769 0.225218805057141 246 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2260 7964312 200 µM 0.75423369882945 0.224161657381899 no 770 0.225354452960263 252 231951 SGTC_1266 0828-0227 32.9 µM 0.753647060705537 0.224338625456318 no 771 0.225530588983924 255 3913820 SGTC_2752 diclazuril 33.15 µM 0.753272349772216 0.224451704051041 no 772 0.225643135384345 241 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2804 7954240 19.48 µM 0.753202645005066 0.224472742812522 no 773 0.225664075082983 243 828705 SGTC_587 k089-0003 57 µM 0.753089983365704 0.224506749471941 no 774 0.225697921588716 252 9659696 SGTC_3083 9117465 49.47 µM 0.752594909056143 0.224656221168321 no 775 0.22584668890648 272 16420915 SGTC_647 0140-0236 81 µM 0.752149846264958 0.224790641669639 no 776 0.225980475339069 240 990837 SGTC_2891 9063876 19.48 µM 0.751868922560332 0.224875511383873 no 777 0.2260649444171 227 6472478 SGTC_961 1252-1571 372 µM 0.748022569296965 0.226039356633724 no 778 0.22722327217989 263 6813498 SGTC_3279 9140807 49.47 µM 0.747792515959617 0.226109074856855 no 779 0.227292658504975 267 45595718 SGTC_2664 lyso-paf C-16 73.48 µM 0.747155643376676 0.226302144018898 no 780 0.227484807736612 270 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_176 1486-1328 72.834 µM 0.746971613878838 0.226357950256732 no 781 0.22754034784829 254 22310231 SGTC_47 0149-0135 24.25 µM 0.746142163634538 0.226609574299602 no 782 0.227790770722342 249 5239155 SGTC_1878 temozolomide 1 mM 0.745496159662974 0.226805656953314 no 783 0.227985915942437 246 5394 DNA alkylating agent. SGTC_304 1310-0298 97 µM 0.745287949594045 0.226868875691675 no 784 0.228048832182895 284 1550234 SGTC_3144 9087057 49.47 µM 0.744870306212421 0.226995714542506 no 785 0.228175063733609 248 17249618 SGTC_2710 st078562 53.7235 µM 0.743776228283969 0.22732817698426 no 786 0.228505931928889 256 17250908 SGTC_1772 st048439 82.2 µM 0.743322678741032 0.227466079548778 no 787 0.22864317218407 246 2927068 YDL195W SEC31 SGTC_1196 1588-0294 184 µM 0.739695049831706 0.228570760770417 no 788 0.229742526216302 249 6144269 SGTC_828 2074-0507 139 µM 0.739576851805519 0.228606804910657 no 789 0.229778395890281 253 X828 SGTC_2299 7976368 114.88 µM 0.739387874623377 0.228664439577578 no 790 0.229835751500427 249 2979718 SGTC_792 4534-1957 155 µM 0.73875679764902 0.228856965897231 no 791 0.230027344886068 251 1717904 SGTC_60 0986-0278 202 µM 0.738118100719361 0.229051909482403 no 792 0.230221342639601 265 3110598 SGTC_643 k048-0106 28.4 µM 0.73580204393102 0.229759598997145 no 793 0.230925588584698 262 6763920 SGTC_3126 9127922 49.47 µM 0.734941729274019 0.230022786512697 no 794 0.231187491465058 284 45595682 SGTC_856 0433-0016 11.3 µM 0.734922190069119 0.230028765906246 no 795 0.231193441647782 256 3911780 SGTC_1172 0370-0043 85 µM 0.733923728432185 0.230334431208388 no 796 0.231497612220204 248 376585 SGTC_404 fumagillin 50 µM 0.733562492532024 0.23044507453623 no 797 0.231607713778399 271 12015870 A methionine aminopeptidase binder. SGTC_2220 6782180 200 µM 0.733330189300229 0.230516242633671 no 798 0.231678533197919 236 833803 SGTC_1968 st069590 43.6 µM 0.733115343903832 0.230582073305375 no 799 0.23174404120208 264 6384066 SGTC_1696 st025591 34.7925 µM 0.732434567890187 0.230790738917369 no 800 0.231951683158668 253 2787147 SGTC_1797 st048695 56.8 µM 0.725657299686741 0.232873790388752 no 801 0.234024442395491 284 592262 YIL048W NEO1 SGTC_2004 4023728 41.89 µM 0.72451392116895 0.233226244413284 no 802 0.234375141863562 281 360084 YDR527W RBA50 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.724367480276895 0.233271407170345 no 803 0.234420079522925 271 2346 DNA damaging agent; causes G2/M arrest. SGTC_3310 9130229 44.1445 µM 0.724206802776457 0.233320966118673 no 804 0.234469391391196 248 7761258 SGTC_2667 digitoxin 100 µM 0.723434050878544 0.233559393293191 no 805 0.234706628828993 234 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3210 9128157 49.47 µM 0.722770604113762 0.233764202889434 no 806 0.234910415065999 260 17590849 SGTC_1758 st042942 75.2445 µM 0.721317488259062 0.234213135185334 no 807 0.235357099784307 260 669317 SGTC_448 monastrol 171 µM 0.720169474417492 0.234568145098796 no 808 0.23571032804944 277 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_234 nsc-17383 10.7 µM 0.714694933841884 0.236265170202045 no 809 0.237398784444865 241 408974 SGTC_1671 st016596 74.5 µM 0.71401291890341 0.236477057135322 no 810 0.237609595498685 275 2829167 SGTC_217 ketoconazole 989 nM 0.713526073664425 0.236628373116897 no 811 0.237760142344434 247 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3194 9111903 49.47 µM 0.712905769176324 0.23682124660965 no 812 0.237952034485896 269 17087251 SGTC_1401 3807-4679 7.6 µM 0.712902805724626 0.236822168253717 no 813 0.237952951437952 276 3291456 SGTC_2595 hexamethylquercetagetin 100 µM 0.712847562692495 0.236839349395159 no 814 0.237970045107101 276 386331 SGTC_1677 st019204 53.9 µM 0.712388399649762 0.236982180262205 no 815 0.238112148459811 260 3945625 SGTC_834 0312-0008 75.7 µM 0.711994152542456 0.237104855635678 no 816 0.238234198502345 270 6385573 YIL048W NEO1 SGTC_2164 5685496 200 µM 0.711198981407854 0.237352390124736 no 817 0.238480469851129 270 759046 SGTC_1109 tnp00067 928.257 nM 0.710985185908381 0.237418968246642 no 818 0.238546707925444 259 676295 SGTC_2917 7979103 53.79 µM 0.71076948831532 0.237486149089033 no 819 0.238613545510058 251 2980565 SGTC_1608 st001473 40.5 µM 0.710112711511659 0.237690772031514 no 820 0.238817122124949 284 7292267 SGTC_2593 nobiletin 86.24 µM 0.7095385675004 0.237869729415647 no 821 0.238995163416123 253 72344 An anti-infammatory. SGTC_233 rapamycin 362 pM 0.709038021316472 0.238025807046206 no 822 0.239150441312176 268 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_711 k292-0785 179 µM 0.707233098965557 0.238589074143623 no 823 0.239710816346828 271 4146315 SGTC_1555 citronellol 128 µM 0.705993792249701 0.238976250045553 no 824 0.240095998965533 264 8842 A terpine precursor. SGTC_2229 7354935 190 µM 0.705989254338281 0.238977668380405 no 825 0.24009740999043 284 318112 SGTC_2037 5169046 200 µM 0.705582147681443 0.239104929246354 no 826 0.240224014729533 253 5718022 SGTC_3214 9129694 49.47 µM 0.702475620230767 0.24007724324803 no 827 0.241191300268582 277 17158655 SGTC_52 0329-0193 875 nM 0.701260018090108 0.240458301279828 no 828 0.241570380183364 287 3739292 SGTC_3104 9120930 49.47 µM 0.700330349599444 0.240749949074291 no 829 0.241860511189006 275 17014836 SGTC_1594 piperine 70.1 µM 0.698931154831034 0.241189255350751 no 830 0.242297528153695 257 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_795 0685-0265 78 µM 0.698802518571736 0.241229665236963 no 831 0.24233772717963 257 302754 SGTC_1059 3448-6867 171 µM 0.6957901339265 0.242177029128964 no 832 0.243280134399729 281 3934407 SGTC_3167 9103034 49.47 µM 0.695661284668328 0.242217595823038 no 833 0.243320488278366 262 5127859 SGTC_3119 9125183 49.47 µM 0.695509019781537 0.242265539404041 no 834 0.243368180284363 249 22695334 SGTC_1553 gossypol 38.6 µM 0.695434449352804 0.242289021239758 no 835 0.243391538879836 262 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2297 7971671 152.32 µM 0.695228740703076 0.242353804205499 no 836 0.243455981762948 266 909016 SGTC_1384 3089-0840 101 µM 0.694742739400418 0.242506895840419 no 837 0.243608269262164 252 1069836 SGTC_1548 st061468 90.8 µM 0.692871283775749 0.243096897959033 no 838 0.244195166136837 272 390799 SGTC_2165 5727197 32.143 µM 0.690959127021385 0.243700532517589 no 839 0.244795613592314 273 1361712 SGTC_3328 9140624 29.0385 µM 0.689143397250963 0.244274474975645 no 840 0.245366516277225 268 4904392 SGTC_769 0302-0231 76 µM 0.688671080522448 0.244423891095773 no 841 0.245515139539889 291 571869 YER009W NTF2 SGTC_1701 st028638 40.4 µM 0.687324616940827 0.244850111376671 no 842 0.245939094732681 272 3490878 SGTC_3274 9138298 49.47 µM 0.686924478078408 0.244976851569683 no 843 0.246065160411837 281 17015756 SGTC_159 3970-0959 50 µM 0.684846733077614 0.245635524715426 no 844 0.246720320942071 268 6615653 SGTC_1976 st070609 63.5 µM 0.683405659537646 0.246092922438696 no 845 0.247175272398097 267 682556 SGTC_401 neomycin 50 µM 0.682501232904901 0.246380221236184 no 846 0.247461031721992 253 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1320 1313-0481 95.3 µM 0.682346283002272 0.246429460419174 no 847 0.247510006832948 268 6813365 YLR208W SEC13 SGTC_1173 0443-0020 122 µM 0.682044609649376 0.246525339751344 no 848 0.247605371769581 272 5331295 SGTC_1272 0839-0021 27 µM 0.680728640925841 0.246943821149447 no 849 0.248021605063962 284 5027250 SGTC_618 k072-0232 33.2 µM 0.680102243981995 0.247143150429913 no 850 0.248219861859312 278 5872756 YGL099W LSG1 SGTC_82 0054-0107 293.755 µM 0.679601205170335 0.247302650720796 no 851 0.248378503185504 267 3104697 SGTC_3276 9139060 49.47 µM 0.679532362304073 0.247324570402622 no 852 0.24840030476818 302 4870619 SGTC_2172 5754775 163.918 µM 0.678656997553755 0.247603378520753 no 853 0.248677609582654 270 2263357 SGTC_836 0330-0104 1.35 µM 0.677259773587209 0.248048749076176 no 854 0.249120574379979 268 46494820 SGTC_2906 7926292 26.41 µM 0.677103169128144 0.248098693977442 no 855 0.249170249159552 299 2966319 SGTC_2627 acetyl isogambogic acid 100 µM 0.675745309102986 0.248531972777228 no 856 0.249601181794318 284 6857789 A caspase activator and apoptosis inducer. SGTC_3219 9131112 49.47 µM 0.675476376507482 0.248617834135502 no 857 0.249686577621159 266 17612988 YMR079W SEC14 SGTC_1031 k035-0009 16 µM 0.67516292900634 0.24871792758004 no 858 0.249786128119202 279 5180959 SGTC_2048 5246248 200 µM 0.674772573259678 0.248842610194207 no 859 0.249910134029118 263 677046 SGTC_2716 st080858 38.6235 µM 0.670844129691414 0.250099235326072 no 860 0.251159915715001 267 5296050 SGTC_1913 st060213 96.1 µM 0.670490572325518 0.250212495658785 no 861 0.251272557176582 293 688959 SGTC_2847 9005661 71.43 µM 0.670279539467972 0.250280111939512 no 862 0.251339803829634 255 2991449 SGTC_1475 4092-1048 11.7 µM 0.669920260727465 0.250395249435474 no 863 0.251454311641773 286 2881759 SGTC_1801 st050089 28.441 µM 0.669402681568674 0.250561166561454 no 864 0.251619320753499 264 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2491 paeonol 100 µM 0.668917785911761 0.250716659370351 no 865 0.251773961935677 283 11092 Increases levels of cortical cytochrome oxidase. SGTC_2898 9056270 58.44 µM 0.665177081024161 0.251917917038134 no 866 0.252968618882309 241 19154699 SGTC_252 miconazole 1.30953 nM 0.665031823266758 0.251964625053338 no 867 0.253015069478567 275 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1751 st044839 27.194 µM 0.664830038491831 0.252029517063255 no 868 0.253079603758417 261 5291326 SGTC_2994 9053520 71.4286 µM 0.663810425841415 0.252357549321862 no 869 0.253405825988606 280 4647384 SGTC_3333 9141820 12.094 µM 0.663232668362051 0.252543526710001 no 870 0.253590775935663 275 1939433 SGTC_2337 9009472 200 µM 0.662857314276137 0.25266439009162 no 871 0.25371097111823 281 5742383 SGTC_2919 7978188 46.38 µM 0.662554658912443 0.25276186678853 no 872 0.253807908633352 260 2980291 SGTC_2079 5212404 121 µM 0.662348539526075 0.252828263321596 no 873 0.253873937759605 269 758462 SGTC_2292 7671323 168.05 µM 0.660701627448582 0.253359107071673 no 874 0.254401839954982 302 937504 SGTC_2483 5729050 27.16 µM 0.657820136488796 0.254289295938493 no 875 0.25532685680122 292 2865180 SGTC_1809 st050081 57.6 µM 0.65756280784907 0.254372452513742 no 876 0.255409549924893 289 5036894 SGTC_2533 agelasine 13.65 µM 0.657420177684452 0.254418550047567 no 877 0.255455390469525 275 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1694 st024011 44.9 µM 0.656616429912931 0.254678400134711 no 878 0.255713790897635 301 2787533 SGTC_1689 st020265 53.493 µM 0.656547061627905 0.254700833279337 no 879 0.255736098810381 291 5758320 YPR016C TIF6 SGTC_2413 inermin 26.06 µM 0.656399283540134 0.254748626972493 no 880 0.255783625654687 299 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1007 4101-0031 70 µM 0.656036798966156 0.254865879907988 no 881 0.255900223678308 301 1146276 SGTC_2010 4012422 159 µM 0.655926693243414 0.254901501413698 no 882 0.255935646151723 283 952393 SGTC_1648 st011736 69.8 µM 0.654653243529972 0.255313678305895 no 883 0.256345517679477 285 2855514 SGTC_216 k038-0035 28.382 µM 0.652193026626926 0.256110961198162 no 884 0.257138328968668 289 4444231 YPR107C YTH1 SGTC_1412 3909-8563 178 µM 0.650922100252162 0.256523338583587 no 885 0.257548387185267 309 23767530 SGTC_8 0354-0001 70 µM 0.649798549470203 0.256888184857995 no 886 0.25791117801834 276 4993152 SGTC_2398 5228213 48.84 µM 0.648782717815979 0.257218284201692 no 887 0.258239414785215 289 80771 YMR134W ERG29 SGTC_1333 1482-0047 286 µM 0.647721468392746 0.257563377644457 no 888 0.258582558120028 290 3811116 SGTC_1276 0871-0068 94.2 µM 0.647569980756092 0.257612657478226 no 889 0.25863155923191 288 3414906 SGTC_2549 cedrol 20.94 µM 0.647183694440935 0.257738340882695 no 890 0.258756531508056 285 6708665 A sedative which affects the nervous system. SGTC_2694 st077685 81.9 µM 0.646741859025517 0.257882136942625 no 891 0.258899513471745 264 2838096 SGTC_2328 6201408 200 µM 0.646094331583441 0.258092950991805 no 892 0.259109133070569 308 2890418 SGTC_3101 9120531 49.47 µM 0.644540623003651 0.258599152621347 no 893 0.259612462089325 310 24824904 SGTC_689 0833-0039 98 µM 0.643798423697688 0.258841144081216 no 894 0.259853078035845 326 5374726 SGTC_2852 9023854 51.95 µM 0.643210558836129 0.259032898465668 no 895 0.260043741429691 309 19798528 SGTC_2825 7998094 58.44 µM 0.642841539917265 0.259153305479294 no 896 0.260163462919466 293 2987815 SGTC_724 3910-0327 137 µM 0.642498461778883 0.259265274236388 no 897 0.260274793873023 311 2885483 SGTC_1375 2910-0797 186 µM 0.642329155836501 0.259320539011756 no 898 0.260329743731395 299 742508 SGTC_1693 xanthone 101.9 µM 0.641618234391301 0.259552664118446 no 899 0.260560545288359 304 7020 An insecticide. SGTC_1561 5-methoxyflavone 52.9 µM 0.640135550689952 0.26003712463558 no 900 0.261042239190028 283 94525 SGTC_677 0929-0063 136 µM 0.637949410896006 0.260752286011668 no 901 0.261753305948524 311 1539583 SGTC_1945 st075991 56.6 µM 0.637397396232259 0.260933028862806 no 902 0.261933011984991 275 1084980 SGTC_1309 pyrazolanthrone 13.4 µM 0.636423112062767 0.261252190023101 no 903 0.26225034036081 306 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1071 trifluoperazine 6.31 µM 0.636105727858613 0.261356203714431 no 904 0.262353756217036 320 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_972 1319-0219 195 µM 0.635629003013506 0.261512476750706 no 905 0.262509130554817 297 23903702 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.635500754998614 0.261554525345134 no 906 0.262550937233931 308 61125 An anti-inflammatory. SGTC_3059 1327-0034 3 µM 0.632665175794035 0.262485110752339 no 907 0.263476157804014 290 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2781 5567276 71.43 µM 0.632408692334239 0.262569367459933 no 908 0.263559927737736 301 2853274 SGTC_411 enrofloxacin 100 µM 0.630342647662861 0.263248582834998 no 909 0.26423521286545 278 71188 A bacterial gyrase inhibitor. SGTC_3340 9146634 11.102 µM 0.629701203859842 0.263459640886173 no 910 0.264445047385588 277 4907387 SGTC_2913 7966556 36.57 µM 0.626328079457123 0.264570939540027 no 911 0.265549886163457 278 2976516 SGTC_1086 cerivastatin 2.18 µM 0.625784017207499 0.264750407615191 no 912 0.265728308254507 272 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2719 novobiocin 32.65 µM 0.625596433649379 0.264812299551255 no 913 0.26578983929225 305 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2218 6965428 192.983 µM 0.623822794042792 0.265397863379085 no 914 0.266371984157018 292 675684 SGTC_1877 wortmannin 25 µM 0.621934281566572 0.26602207377428 no 915 0.266992541049127 302 312145 A covalent inhibitor of PI 3-kinase. SGTC_986 1493-0483 84 µM 0.620532575171042 0.266485860397633 no 916 0.267453607214114 306 40079 SGTC_560 2332-1943 155 µM 0.620194879074655 0.266597655979989 no 917 0.267564746279094 297 21177716 SGTC_1182 1222-0449 220 µM 0.619605542249378 0.266792814976729 no 918 0.267758758509819 302 658318 SGTC_90 0870-0863 4.608 µM 0.619077927451346 0.266967595941841 no 919 0.267932511698371 320 1738164 SGTC_1459 k035-0031 35.7 µM 0.617172922623484 0.267599140704887 no 920 0.268560336829884 287 3877128 YMR208W ERG12 SGTC_625 k213-0058 121 µM 0.616331435047268 0.267878349210023 no 921 0.268837897925444 301 3655420 SGTC_2768 sulfasalazine 50.2 µM 0.615511678952665 0.268150488159977 no 922 0.269108429445764 307 5384001 An antioxidant and salicylic acid derivative. SGTC_1483 3453-0561 55.9 µM 0.615320038531135 0.26821412814672 no 923 0.269171693287027 310 4546991 SGTC_1760 st045453 10.4495 µM 0.614961403265962 0.268333244226951 no 924 0.269290105078519 315 3323419 YIL048W NEO1 SGTC_1269 0831-0796 3.05 µM 0.614837512329135 0.26837439918721 no 925 0.269331016629026 298 927758 SGTC_1881 5652484 16 µM 0.614834606537326 0.268375364491611 no 926 0.269331976223696 307 2255129 SGTC_1546 5-methoxyflavanone 78.7 µM 0.611477467445885 0.26949177157345 no 927 0.270441765505724 285 147795 SGTC_3337 9144342 33.5465 µM 0.610094966072863 0.269952194171375 no 928 0.270899450536642 278 17682949 SGTC_536 3852-0578 10.6 µM 0.610050451454771 0.269967025677287 no 929 0.270914193777685 308 2869208 SGTC_7 0192-1582 4.227 µM 0.609766475745652 0.270061651102326 no 930 0.271008255952793 320 252616 SGTC_860 0443-0016 25.1 µM 0.608522564416156 0.270476338470382 no 931 0.271420472534628 301 5337942 SGTC_1251 0490-5699 265 µM 0.607973059382869 0.2706596302872 no 932 0.271602671023698 297 3883818 SGTC_527 4476-4215 268 µM 0.602009403893528 0.272652836263683 no 933 0.273583938862321 291 4418754 SGTC_2415 st077333 57.7 µM 0.597024244271426 0.274324575341042 no 934 0.275245597056068 317 2766255 SGTC_1779 st039427 55 µM 0.595606447571844 0.274800946333291 no 935 0.275719084191191 331 1124498 SGTC_1204 4049-0315 18.3 µM 0.59521211620494 0.274933511698445 no 936 0.275850846149007 306 588402 SGTC_1365 1672-3266 55.4 µM 0.594274030123202 0.275249001802187 no 937 0.276164422695569 308 6415873 SGTC_3190 9110366 49.47 µM 0.592744878155626 0.275763656486319 no 938 0.276675951173296 306 17123768 SGTC_2962 9082311 13.18 µM 0.592334429936581 0.275901878287195 no 939 0.276813332383949 318 16459453 SGTC_1248 0469-0687 58.6 µM 0.590988947912458 0.276355218885008 no 940 0.277263913108947 306 4017482 SGTC_1930 st074634 34.3 µM 0.589306398958239 0.276922642956589 no 941 0.277827876538909 303 684253 YOR116C RPO31 SGTC_736 0958-0254 92.6 µM 0.588894185252832 0.27706174516563 no 942 0.277966129326334 320 6812352 SGTC_1902 st060212 70.5 µM 0.588391330075747 0.277231480782469 no 943 0.278134827897891 301 688944 SGTC_2920 7982904 15.77 µM 0.587662637479574 0.277477536631345 no 944 0.278379379307191 300 6456808 SGTC_3156 9099931 49.47 µM 0.587630993670037 0.277488224137027 no 945 0.278390001437768 319 18111053 SGTC_1332 1480-0653 17.5 µM 0.587348188488232 0.277583748813309 no 946 0.278484941684494 305 5749438 SGTC_2448 5185112 27.17 µM 0.587267281098931 0.277611080306945 no 947 0.278512105925447 289 5718189 SGTC_759 3486-0358 89.3 µM 0.586332297093903 0.277927024554468 no 948 0.278826115622854 312 875103 SGTC_2819 7996655 46.38 µM 0.584219888519464 0.278641482614411 no 949 0.27953619117232 298 6456960 SGTC_1645 Cervolide 78 µM 0.583905991084722 0.278747725163439 no 950 0.279641781101263 328 23173 A fragrance. SGTC_1741 st038134 10.228 µM 0.582368958503105 0.279268237729863 no 951 0.280159092848799 325 1272587 SGTC_2137 5261020 140 µM 0.580412625953837 0.279931427693398 no 952 0.280818196353661 308 763655 SGTC_235 0330-0087 5 mM 0.579577138939838 0.280214887431052 no 953 0.281099906648831 306 46494818 YHR062C RPP1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.579305720931065 0.280307002652909 no 954 0.281191452996843 306 75037 A free radical scavenger. SGTC_366 0181-0206 4.31 µM 0.578514412471324 0.28057564461169 no 955 0.281458434898029 318 274874 SGTC_1380 2291-0730 164 µM 0.578247188068995 0.280666392975023 no 956 0.281548622147019 294 2999191 SGTC_3038 9091290 49.47 µM 0.577842343320391 0.28080390371454 no 957 0.281685282304746 328 25236843 SGTC_2744 captopril 92.04 µM 0.5714647009759 0.282974440028203 no 958 0.283842340802521 280 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_974 1326-0144 138 µM 0.56757077094526 0.284303629874712 no 959 0.285163229482434 321 5411856 SGTC_3342 9147791 14.508 µM 0.567238148260257 0.284417308559272 no 960 0.285276196548194 305 1838168 SGTC_3008 9078912 71.4286 µM 0.566744278460986 0.284586135862766 no 961 0.285443966525767 319 16648731 SGTC_3346 9158254 43.5805 µM 0.564512088356688 0.28534979696122 no 962 0.286202837824949 321 17639500 SGTC_1081 sertraline 6 µM 0.564446273942727 0.285372327728596 no 963 0.286225227098061 320 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2823 7987624 58.44 µM 0.564321329510543 0.28541510327235 no 964 0.286267733981431 333 2239440 SGTC_2606 farnesol 9.78 µM 0.564150385673473 0.285473631959159 no 965 0.286325895007709 323 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.562536276927104 0.286026560869376 no 966 0.286875347196628 287 641818 YHR062C RPP1 SGTC_2722 naftopidil 47.16 µM 0.56174747328413 0.286296958360859 no 967 0.287144042255608 327 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3302 9125395 16.351 µM 0.561619682928646 0.286340775603365 no 968 0.287187583486195 303 17599668 SGTC_2013 4024628 200 µM 0.560118579023083 0.286855717993827 no 969 0.287699279315373 331 5230760 SGTC_2713 st079149 53.4 µM 0.559740816092191 0.286985375804402 no 970 0.287828118843441 312 3103253 SGTC_1667 st014849 34.6 µM 0.55766205841117 0.287699354333854 no 971 0.288537585443714 299 5348460 SGTC_1472 k841-0093 193 µM 0.555713516994095 0.288369369434024 no 972 0.289203357325191 327 X1472 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.55469682022512 0.288719257199577 no 973 0.28955102575466 321 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_503 tyrphostin 8 294 µM 0.554190252746769 0.288893662782163 no 974 0.289724324192314 353 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_168 3970-0862 530.542 µM 0.553237132117147 0.28922194601414 no 975 0.290050521843108 329 3135186 SGTC_2442 5158906 48.48 µM 0.552275592620538 0.28955330653998 no 976 0.290379775117071 303 1893835 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.552133804684079 0.289602183806615 no 977 0.290428341373993 341 91467 include heat shock SGTC_990 3985-0011 41.3 µM 0.550358094920079 0.290214635853295 no 978 0.291036892431323 338 5399565 YGL099W LSG1 SGTC_2767 sibutramine 71.45 µM 0.549596476894429 0.290477507902991 no 979 0.291298087911651 328 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1211 1056-0033 32.3 µM 0.548366567614041 0.290902245565907 no 980 0.291720113841268 298 6741922 SGTC_857 0438-0306 1.35 µM 0.547120415879181 0.291332888211654 no 981 0.292148003529522 304 4686136 SGTC_894 0960-0238 55.9 µM 0.546709995934894 0.291474785421459 no 982 0.292288992861885 323 6741907 YDL195W SEC31 SGTC_1381 2324-0066 62.1 µM 0.542926554333555 0.292784375532446 no 983 0.293590186001021 331 10885928 SGTC_663 1486-0733 13.9 µM 0.542456494699877 0.292947271300178 no 984 0.293752035030143 324 722445 YPR165W RHO1 SGTC_2663 amphotericin b 100 µM 0.541576857584106 0.293252216118907 no 985 0.294055018987897 321 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2534 helenine 20.12 µM 0.540674396022189 0.293565226351265 no 986 0.294366014682833 330 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3253 9135987 49.47 µM 0.538402475547462 0.294353904566967 no 987 0.295149608839806 315 4182430 SGTC_2407 paclitaxel 400 µM 0.538224923006641 0.294415581645014 no 988 0.295210887840383 369 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_438 sphingosine 6.67 µM 0.536758337678161 0.294925262788675 no 989 0.295717276688433 300 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1509 1326-1131 80 µM 0.535302888377186 0.295431475446274 no 990 0.296220214699816 306 768313 SGTC_1626 st003712 1.76 µM 0.533129959995425 0.296187973813963 no 991 0.296971810555665 333 24207035 SGTC_3224 9130643 49.47 µM 0.533115063350411 0.296193163101085 no 992 0.296976966177209 315 17644395 SGTC_1975 st070967 30.8 µM 0.532355116768167 0.296457947892951 no 993 0.297240032520378 333 261391 SGTC_2102 5377816 72.7585 µM 0.53210691502173 0.296544451214265 no 994 0.297325974159151 341 1379702 SGTC_331 k048-0133 24.5 µM 0.532042936941766 0.296566750741751 no 995 0.297348128869426 314 6813582 SGTC_2712 st079126 47.7 µM 0.531445519628587 0.296775017314138 no 996 0.297555042482955 328 3152970 SGTC_2108 5365811 200 µM 0.531376936600413 0.296798930433286 no 997 0.297578800205119 296 780283 SGTC_2820 7989630 71.43 µM 0.530659660358785 0.297049078845215 no 998 0.29782732242943 292 2984098 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.528352886706552 0.297854213667829 no 999 0.298627215454673 360 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3141 9094609 49.47 µM 0.527206507616194 0.298254704975102 no 1000 0.299025095020026 333 25236309 YDL196W YDL196W SGTC_1804 st050076 49.1 µM 0.526834482133785 0.29838472598077 no 1001 0.299154267493449 320 3895976 SGTC_604 1000-0114 314 µM 0.525731079376603 0.298770511247039 no 1002 0.299537533294921 334 1572745 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.524762453983345 0.29910936072525 no 1003 0.299874167636557 312 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2563 tomatine 8.54 µM 0.523584941490641 0.299521518927107 no 1004 0.300283628704889 379 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.523223438668772 0.299648105392505 no 1005 0.3004093861908 325 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1278 0874-0585 172 µM 0.521811502183885 0.300142751411354 no 1006 0.300900790184689 318 766306 SGTC_1876 myriocin 605 nM 0.52070720695752 0.300529878113653 no 1007 0.301285376549147 364 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2347 9049783 174.81 µM 0.520581616352318 0.300573919998182 no 1008 0.301329129261893 357 6467988 YPL169C MEX67 SGTC_1394 3474-0001 65.7 µM 0.520373782530528 0.300646809184847 no 1009 0.301401539795047 309 5017666 YIL048W NEO1 SGTC_2216 7189485 200 µM 0.520356335343398 0.300652928432963 no 1010 0.301407618854624 332 731273 SGTC_2152 5568786 200 µM 0.519318305791766 0.301017097433927 no 1011 0.301769394967294 350 5399883 SGTC_1815 st051655 58.2 µM 0.51859587792106 0.301270662069021 no 1012 0.30202129210019 325 5984156 SGTC_3157 9099274 49.47 µM 0.516680755943062 0.301943314905296 no 1013 0.302689515960095 324 17217662 SGTC_2791 5663188 71.43 µM 0.516672404758879 0.301946249588517 no 1014 0.302692431303064 362 54690634 SGTC_193 1273-0060 1.558 µM 0.516622268199989 0.301963868307555 no 1015 0.30270993390745 327 2847393 YHR072W ERG7 SGTC_3125 9127534 49.47 µM 0.516386876877721 0.302046594429364 no 1016 0.302792114757631 315 1639235 SGTC_3023 9089636 49.47 µM 0.516145164170849 0.302131552733464 no 1017 0.302876512953234 344 17249241 SGTC_1448 4255-0083 152 µM 0.51612912075731 0.302137192126559 no 1018 0.302882115162804 361 5399660 SGTC_2545 solidagenone 89.61 µM 0.515222924051252 0.302455804476512 no 1019 0.303198625834535 315 6708572 An anti ulcer agent SGTC_538 2922-0838 53.3 µM 0.513398270282894 0.30309779643357 no 1020 0.303836377648691 310 777039 SGTC_2246 7293507 91.5585 µM 0.512896612408177 0.30327440810216 no 1021 0.30401182160834 330 887656 SGTC_2114 5491910 81.25 µM 0.511747840895706 0.303679013195025 no 1022 0.304413749538616 373 2849228 SGTC_1844 rapamycin 4 nM 0.511049234131008 0.303925184972061 no 1023 0.304658291089133 315 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_900 1112-0045 141 µM 0.510228500627569 0.304214504822777 no 1024 0.3049456936478 323 56211 YIL048W NEO1 SGTC_2997 9067075 71.4286 µM 0.509663798848724 0.304413641186191 no 1025 0.305143509525191 357 27209819 SGTC_1263 0774-1208 64.8 µM 0.509517653932825 0.304465187160499 no 1026 0.30519471358469 360 906585 SGTC_1428 4049-0204 61.7 µM 0.509077758147533 0.304620363834728 no 1027 0.305348860667746 350 X1428 SGTC_3171 9103192 49.47 µM 0.507855343422669 0.305051764750276 no 1028 0.305777397104719 341 13018434 SGTC_963 1269-2853 151 µM 0.50768489867857 0.305111937745413 no 1029 0.305837170303565 301 3668223 SGTC_2421 5690543 90.72 µM 0.507597935296037 0.305142640910976 no 1030 0.30586766945014 363 3397993 SGTC_1649 st011737 51.3 µM 0.506735031444342 0.305447370781071 no 1031 0.306170373560822 319 1761035 SGTC_2844 9010103 25.97 µM 0.505649826084272 0.305830796659998 no 1032 0.306551248303938 353 2480525 SGTC_2544 sphondin 68.51 µM 0.504317983512363 0.306301655663336 no 1033 0.307018971048653 315 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_29 0299-0004 12.984 µM 0.503990504969018 0.306417481331721 no 1034 0.307134024665008 325 16871 A napthoquinone isolated from Swertia calycina. SGTC_3054 9094397 49.47 µM 0.500725927356028 0.307573183697539 no 1035 0.308282011273022 351 2598354 SGTC_3071 9117417 49.47 µM 0.500125225186194 0.307786048644854 no 1036 0.308493452660192 341 45595590 YGL055W OLE1 SGTC_661 1304-0007 33.6 µM 0.499231475325108 0.308102877787357 no 1037 0.308808161581898 343 3117130 SGTC_104 0074-0074 590.992 µM 0.498703261334233 0.308290193858065 no 1038 0.308994223354266 330 3943124 SGTC_13 0199-0087 65 µM 0.497547049375982 0.308700385760929 no 1039 0.309401666530051 341 4589825 SGTC_3327 9140648 26.9345 µM 0.497428027476324 0.308742624991232 no 1040 0.309443622555129 370 8029710 SGTC_1908 st060353 56.5 µM 0.497000129946781 0.308894500818691 no 1041 0.309594479845188 360 4227716 SGTC_808 0711-0032 135 µM 0.496430669835737 0.309096672853124 no 1042 0.309795295450549 355 4252555 SGTC_1972 st070201 17.4 µM 0.494732822479189 0.30969979257359 no 1043 0.310394364705727 337 2829099 SGTC_3208 9114115 49.47 µM 0.494394759316245 0.309819942695864 no 1044 0.310513707209519 360 650895 SGTC_513 4245-1575 41.7 µM 0.493999532038354 0.309960435125769 no 1045 0.310653254987761 339 719745 SGTC_112 phenothiazine 287.218 µM 0.491877363949501 0.310715281735947 no 1046 0.31140302064185 362 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1907 st060210 83.7 µM 0.490283091609842 0.31128288278217 no 1047 0.311966795051793 358 688793 SGTC_2396 5342950 42.78 µM 0.490273378432843 0.311286342294817 no 1048 0.311970231225336 330 1886677 SGTC_100 0086-0128 49.5915 µM 0.487907276067695 0.312129565716705 no 1049 0.31280776025375 355 93297 SGTC_482 fipronil 114 µM 0.485412813290055 0.313019600767418 no 1050 0.313691772516835 347 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2104 5389443 200 µM 0.484917083151916 0.313196609497366 no 1051 0.313867581950965 357 2244536 SGTC_2551 apiole 73.87 µM 0.484901800828605 0.313202066990536 no 1052 0.313873002459868 332 10659 A possible DNA adduct former. SGTC_2815 7968870 71.43 µM 0.482347163279749 0.314114931701201 no 1053 0.314779674295508 344 2977326 YHR190W ERG9 SGTC_888 0916-0002 6.97 µM 0.48090099059383 0.31463220673974 no 1054 0.315293434353332 327 2802138 YIL048W NEO1 SGTC_99 0109-0120 622.8 µM 0.479523520802997 0.315125246293135 no 1055 0.315783119737158 360 759414 SGTC_2017 5132927 60.65 µM 0.479361719037427 0.315183181853184 no 1056 0.315840660911651 337 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2038 4100038 30.985 µM 0.479015480644882 0.315307172997453 no 1057 0.315963807834771 343 3596803 SGTC_158 k038-0087 26.446 µM 0.476604411426271 0.316171175245986 no 1058 0.316821920751049 343 X158 SGTC_318 1488-0629 67.2 µM 0.473876561730221 0.317149906685381 no 1059 0.317793967002786 374 3662576 SGTC_927 2425-1185 123 µM 0.4734870512608 0.317289764661953 no 1060 0.317932868493095 364 730375 SGTC_1386 3228-0095 33.8 µM 0.4728168192815 0.317530479827282 no 1061 0.318171936716689 363 870181 SGTC_3293 9120939 62.045 µM 0.472696011101153 0.317573876540377 no 1062 0.318215036421734 364 934087 SGTC_820 1582-0060 59.9 µM 0.469741704572703 0.318635901548364 no 1063 0.319269784050493 341 3848840 SGTC_380 3970-0968 6 µM 0.469672026680767 0.318660967651262 no 1064 0.319294678186535 347 2891601 SGTC_2885 9057732 51.95 µM 0.469656649331981 0.318666499649785 no 1065 0.319300172231325 346 6471414 SGTC_596 1155-0152 116 µM 0.469650267312383 0.318668795592081 no 1066 0.319302452421569 347 280313 SGTC_2219 9098279 200 µM 0.469382738788488 0.318765045690151 no 1067 0.319398042093802 339 902349 SGTC_1698 5-fluorocytosine 1.055 µM 0.469014783457725 0.318897446823382 no 1068 0.319529534522127 348 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1185 1319-0113 81.3 µM 0.468727145822353 0.319000963389468 no 1069 0.319632340443347 359 4672763 SGTC_2129 girgensonine 121.053 µM 0.467819929238713 0.319327549789939 no 1070 0.319956683768364 356 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_537 1334-0398 209 µM 0.467055092303813 0.319602990292321 no 1071 0.320230231242992 358 5846986 SGTC_369 0957-0393 4.5 µM 0.466928810215039 0.319648477802436 no 1072 0.320275406021314 344 6997992 SGTC_2429 5902844 64.44 µM 0.466183346218498 0.319917053338946 no 1073 0.320542134444806 367 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1901 st060216 58.6 µM 0.46612817847096 0.319936932911952 no 1074 0.320561877254681 344 688792 SGTC_1750 st081859 2.357 µM 0.465013099656683 0.320338859830765 no 1075 0.320961037831095 369 5291695 SGTC_3116 9124943 49.47 µM 0.465009594096015 0.32034012373263 no 1076 0.320962293030139 318 41905195 YPL160W CDC60 SGTC_3213 9129884 49.47 µM 0.464892484653904 0.320382347803076 no 1077 0.321004226345713 335 17190742 SGTC_1441 4106-0040 13 µM 0.464891749328243 0.320382612933729 no 1078 0.321004489650594 348 2904180 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.464566345997567 0.320499950076607 no 1079 0.321121018671658 343 97141 SGTC_2862 9027634 71.43 µM 0.464035190296608 0.320691517983467 no 1080 0.321311266780504 324 5012562 SGTC_1360 1598-0022 39.8 µM 0.463412553018394 0.320916140669974 no 1081 0.321534341252494 376 761525 SGTC_1732 st034308 51.822 µM 0.462514288763609 0.321240314083193 no 1082 0.32185627899198 326 830119 SGTC_1000 4048-0884 8.67 µM 0.461011859600356 0.321782828223036 no 1083 0.322395048226999 362 13040088 SGTC_1175 0741-0056 27.6 µM 0.459833293900607 0.322208664232949 no 1084 0.322817941744653 360 765927 SGTC_1612 st002233 45.4 µM 0.458898489586004 0.322546591140688 no 1085 0.323153531733994 345 1035021 SGTC_427 1354-0053 47.3 µM 0.4588960187787 0.322547484519138 no 1086 0.323154418932136 369 6813657 SGTC_1194 1488-0194 225 µM 0.458407758558427 0.322724046577238 no 1087 0.323329759324424 353 1391452 SGTC_2598 perillyl alcohol 100 µM 0.457722626076318 0.322971867929154 no 1088 0.323575865195908 344 10819 An apoptosis inducer. SGTC_253 dyclonine 31.25 µM 0.45739348746402 0.323090949619008 no 1089 0.323694122258507 337 3180 An oral anasthetic. SGTC_1525 8-methoxypsoralen 92.5 µM 0.45571294808038 0.323699247846133 no 1090 0.324298204914279 390 4114 Related to psoralen; DNA damaging agent. SGTC_2763 lisinopril 49.32 µM 0.455204166093823 0.323883502678547 no 1091 0.324481181796327 373 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3003 9075612 71.4286 µM 0.452662977108889 0.324804436910556 no 1092 0.325395721391757 372 6501993 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.452191729760243 0.324975336291674 no 1093 0.325565432786588 351 521171 SGTC_3108 9121785 49.47 µM 0.451674062555466 0.325163112441634 no 1094 0.325751903158099 372 17140271 SGTC_1416 3966-0321 25.3 µM 0.451050030549356 0.32538952988809 no 1095 0.325976745457348 336 582530 YLR208W SEC13 SGTC_1103 duloxetine 36.1 µM 0.45057914997905 0.325560422098688 no 1096 0.32614644832283 357 60835 A selective serotonin reuptake inhibitor. SGTC_3178 9107506 49.47 µM 0.448844043903108 0.326190443973726 no 1097 0.326772081947646 357 8897194 SGTC_1195 1502-0147 41.1 µM 0.448018273562061 0.326490457942215 no 1098 0.327070004299833 343 817940 SGTC_387 norethindrone acetate 66.7 µM 0.447818267996679 0.32656313967091 no 1099 0.327142179122596 372 541197 SGTC_1552 6-methylflavone 10.6 µM 0.447683268168377 0.326612202132285 no 1100 0.327190899364941 368 689013 SGTC_2357 9067248 200 µM 0.447558591521941 0.326657515543681 no 1101 0.327235896677858 370 9150235 SGTC_2884 9058502 51.95 µM 0.447466755629543 0.326690894701817 no 1102 0.327269042970547 357 6471554 SGTC_408 cantharidin 100 µM 0.446290601007777 0.327118508644387 no 1103 0.327693672352074 343 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3143 9086658 49.47 µM 0.444782794645411 0.327667033110143 no 1104 0.328238364652974 361 25236626 SGTC_2041 5107442 45.335 µM 0.444156864472001 0.32789484944963 no 1105 0.32846458817812 362 793005 SGTC_3237 9133362 49.47 µM 0.443712558493576 0.328056599916599 no 1106 0.328625207308379 387 43845137 SGTC_1872 amphotericin b 148 nM 0.443631750253198 0.328086021782897 no 1107 0.32865442334978 366 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.442938279478392 0.328338554778825 no 1108 0.328905189227503 356 279621 SGTC_810 3825-7150 143 µM 0.442422850557201 0.328526303227628 no 1109 0.329091623327848 337 22330411 YGL099W LSG1 SGTC_2858 9025781 8.96 µM 0.44203402054474 0.328667965830355 no 1110 0.329232293891585 352 4894980 YPL153C RAD53 SGTC_6 0844-0013 19.835 µM 0.441972074452726 0.32869053695082 no 1111 0.329254706925097 372 1584900 SGTC_675 1309-0189 238 µM 0.440853191697821 0.329098328580571 no 1112 0.329659641210075 320 4246530 SGTC_1749 st037932 54.2 µM 0.439732518570802 0.32950697669477 no 1113 0.330065423715644 390 594497 SGTC_1454 4239-0054 42.6 µM 0.439389364935726 0.329632146788588 no 1114 0.330189715613552 377 1340767 SGTC_1805 st050013 60.3 µM 0.438827254878673 0.329837225539325 no 1115 0.330393355070851 362 4037144 SGTC_2420 aureobasidin a 50 nM 0.438585799724652 0.329925333112853 no 1116 0.330480844109637 332 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3128 9127691 49.47 µM 0.438573538674242 0.329929807451782 no 1117 0.330485287034926 388 41316314 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.438348052059147 0.330012097034766 no 1118 0.33056699882748 348 88881 An O-methylated flavonoid and antioxidant. SGTC_1782 st039423 80.636 µM 0.436831134614648 0.330565897867441 no 1119 0.331116908823266 357 2068169 SGTC_195 4234-0266 16.654 µM 0.436383587856578 0.330729360564815 no 1120 0.331279222296533 367 2303354 SGTC_566 0958-0068 16.5 µM 0.436114825722922 0.330827539196614 no 1121 0.331376710512231 356 6815365 SGTC_335 4077-0256 27.6 µM 0.435178497938981 0.331169669983822 no 1122 0.331716434348709 368 3121989 SGTC_1203 3992-3522 103 µM 0.433886908428493 0.331641843473178 no 1123 0.332185283460237 400 5322312 SGTC_1273 0849-0096 14.1 µM 0.432911011858528 0.331998784909441 no 1124 0.332539709861863 375 5286025 SGTC_1106 tegaserod maleate 11.7 µM 0.432871301970123 0.33201331232808 no 1125 0.332554134883679 374 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_336 4111-0029 111 µM 0.432247708078002 0.332241480287653 no 1126 0.33278069423187 381 3131175 SGTC_2662 daunorubicin 22.37 µM 0.432207111677118 0.332256336339491 no 1127 0.332795445523016 339 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1089 terbinafine 2.25 µM 0.431924841131747 0.3323596391345 no 1128 0.332898019775612 373 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1267 0828-0272 9.49 µM 0.431102735535277 0.332660578370698 no 1129 0.333196835841182 357 745334 SGTC_2359 9039622 200 µM 0.430813156198653 0.332766607221271 no 1130 0.333302116359935 380 6463596 SGTC_3282 9108498 15.4605 µM 0.429092818568122 0.333396780675392 no 1131 0.333927839138931 349 16459645 SGTC_194 1486-1323 56.904 µM 0.425629344874448 0.334666904559019 no 1132 0.335188976970415 368 5178754 SGTC_2883 9059145 45.46 µM 0.425100786604784 0.33486090421269 no 1133 0.335381602258983 372 16476510 SGTC_1725 st036284 20.55 µM 0.424811406279165 0.334967135743957 no 1134 0.335487081002622 365 707914 SGTC_2481 5478948 45.16 µM 0.424388007148324 0.335122589378237 no 1135 0.335641432786941 348 77792 SGTC_2995 9067767 71.4286 µM 0.42420259422948 0.335190673783446 no 1136 0.335709034515029 359 11673567 SGTC_2877 9040724 71.43 µM 0.423463253636325 0.33546221659079 no 1137 0.335978651660511 359 6463895 SGTC_375 3970-0961 9.27 µM 0.422970446271645 0.335643261169029 no 1138 0.336158411828809 349 2898222 SGTC_1929 genistein trimethyl ether 50.5 µM 0.422348336382292 0.335871862612775 no 1139 0.336385390878505 370 136420 SGTC_2566 crystal violet carbinol 226 nM 0.421540838673377 0.336168677522067 no 1140 0.336680098291801 388 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_727 3032-0951 202 µM 0.421118337292523 0.3363240186373 no 1141 0.336834335983469 385 3652836 SGTC_270 tamoxifen 5.46 µM 0.420729635917925 0.336466957185805 no 1142 0.336976258937715 387 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2868 9035608 32.47 µM 0.420309037824373 0.336621651854639 no 1143 0.337129854193736 359 6462614 SGTC_2310 7668677 200 µM 0.420030227529669 0.336724212655081 no 1144 0.337231685930063 406 2197143 SGTC_2828 7998861 71.43 µM 0.419789746414373 0.33681268376254 no 1145 0.33731952802527 336 2988188 SGTC_1004 4084-0029 199 µM 0.419382975047399 0.336962352297827 no 1146 0.337468132222903 391 716894 YLR208W SEC13 SGTC_2570 licareol 100 µM 0.418036208692176 0.337458069210084 no 1147 0.337960321941472 359 443158 SGTC_1560 lithocholic acid 53.1 µM 0.417642683999792 0.337602970851598 no 1148 0.338104191979239 374 9903 A bile acid which acts as a detergent. SGTC_1891 st059073 26.2 µM 0.417374483057093 0.337701740225005 no 1149 0.338202258030236 402 688754 SGTC_357 1325-0123 420 µM 0.417335531154051 0.337716085828718 no 1150 0.338216501470886 386 1098503 SGTC_2055 5235184 200 µM 0.415200622762242 0.338502711749638 no 1151 0.338997521481089 400 2836034 SGTC_1423 4048-0112 5.59 µM 0.414121671466643 0.338900529397547 no 1152 0.339392501160459 379 X1423 SGTC_701 4424-0219 185 µM 0.414033522018464 0.338933038725542 no 1153 0.339424778485974 372 2911779 SGTC_2499 avocadenofuran 51.48 µM 0.411549521929864 0.339849625039162 no 1154 0.340334818265139 372 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2296 7971656 126.45 µM 0.411491488132732 0.339871050632257 no 1155 0.340356090707595 361 666570 SGTC_246 cycloheximide 667 µM 0.410662876010538 0.340177023696764 no 1156 0.340659876060935 377 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_982 1491-0518 27.5 µM 0.408751461431336 0.340883233305455 no 1157 0.341361031935333 360 3091256 SGTC_1359 1582-0056 520 nM 0.407172786548786 0.34146692657 no 1158 0.341940543677484 381 3661189 SGTC_3145 9085516 49.47 µM 0.407158598578844 0.341472174098358 no 1159 0.341945753594535 363 25236195 SGTC_2433 5607874 27.82 µM 0.406843994525038 0.341588540667368 no 1160 0.342061286029389 365 2252428 SGTC_70 0141-0289 43.283 µM 0.406797638185814 0.341605688344282 no 1161 0.342078310775338 351 352408 SGTC_1128 3448-9350 235 µM 0.40617260821228 0.341836925134727 no 1162 0.342307889496379 316 619386 SGTC_3091 9116372 49.47 µM 0.405558126661792 0.342064317278484 no 1163 0.342533650517323 349 17169793 SGTC_3306 9127676 59.7925 µM 0.40545156074546 0.342103758390482 no 1164 0.342572808648887 339 41905287 SGTC_2487 5918373 44.05 µM 0.403536426931655 0.342812861898455 no 1165 0.343276821365444 396 2876279 SGTC_2905 7799065 20.05 µM 0.403185431505746 0.342942882734589 no 1166 0.343405908112307 388 1296806 SGTC_1191 1487-1166 10.6 µM 0.403036371586663 0.342998105308246 no 1167 0.34346073389844 387 3955771 SGTC_1154 4088-0362 150 µM 0.402708768110906 0.343119485111183 no 1168 0.343581241432099 370 6618304 SGTC_1880 MG-132 525 µM 0.40269659504389 0.343123995645421 no 1169 0.343585719549036 394 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.401966912210903 0.343394408691242 no 1170 0.343854188694422 363 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2790 5423970 71.43 µM 0.396539924680893 0.345408102957114 no 1171 0.345853380469606 377 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_550 4123-0385 25.7 µM 0.396528258622878 0.345412436412155 no 1172 0.345857682664897 363 5731123 SGTC_475 α-linolenic acid 10 µM 0.396210713982292 0.34553039881135 no 1173 0.345974794049507 364 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2918 7977171 22.06 µM 0.395690043513585 0.345723851442271 no 1174 0.346166850712839 367 2236483 SGTC_1635 st007035 42.4 µM 0.394790922659443 0.346058010346696 no 1175 0.346498597296698 355 3716403 SGTC_1557 sumaresinolic acid 42.3 µM 0.393869228474504 0.346400683114164 no 1176 0.346838794961101 362 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3347 9188721 44.724 µM 0.391093248114529 0.347433511852633 no 1177 0.347864155608315 409 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3250 9135583 49.47 µM 0.390607521405726 0.347614347654175 no 1178 0.34804368260303 357 7699353 SGTC_2912 7964298 10.93 µM 0.389489333719812 0.348030780109099 no 1179 0.348457099719619 374 2975850 SGTC_876 0720-0963 56.8 µM 0.387983064200706 0.348592030723526 no 1180 0.349014283329458 400 765861 SGTC_816 0325-0417 81.3 µM 0.384402351210363 0.349927568183872 no 1181 0.350340129067129 384 68101 SGTC_552 k242-0005 476 µM 0.383478551023643 0.350272430282244 no 1182 0.350682485399302 405 4088318 SGTC_3136 9095672 49.47 µM 0.379336017135674 0.351820386638853 no 1183 0.352219178466308 360 17217380 SGTC_2278 7948257 134.34 µM 0.378297832489328 0.352208715485414 no 1184 0.352604677710198 375 1247028 SGTC_2443 5493264 126.67 µM 0.378175697939908 0.352254409570515 no 1185 0.352650038734561 394 5340055 SGTC_2379 9035213 200 µM 0.376380206624576 0.352926400909245 no 1186 0.353317129423232 406 646551 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.376128486863985 0.353020647790277 no 1187 0.353410688605863 350 688803 SGTC_207 4185-0010 4.486 µM 0.375714978578564 0.353175489797153 no 1188 0.353564400562209 393 3761753 SGTC_653 0203-0016 55.2 µM 0.37545726721939 0.353272004501415 no 1189 0.353660210766155 401 295302 SGTC_3084 9116877 49.47 µM 0.375002806620741 0.353442226162755 no 1190 0.353829189671606 395 27241325 SGTC_2123 5259487 200 µM 0.373452442363011 0.354023147270219 no 1191 0.354405867301774 395 2173474 SGTC_2376 9072922 81.32 µM 0.373322007339037 0.354072036763764 no 1192 0.354454399509702 377 17087968 SGTC_1690 st023502 41.2 µM 0.370632616109882 0.355080606158923 no 1193 0.355455592727066 419 24207482 SGTC_2638 epoxomicin 18 µM 0.369424205439871 0.355534112907673 no 1194 0.355905779335058 405 9915668 A protesome inhibitor. SGTC_1498 4478-3555 97.6 µM 0.367841196065199 0.356128513024718 no 1195 0.356495824641478 390 3437919 SGTC_1644 st010134 20.9 µM 0.365517891464734 0.357001517813864 no 1196 0.357362426952562 411 3818134 SGTC_1830 st055982 50.3 µM 0.36517255185958 0.35713134667773 no 1197 0.357491303015822 416 455313 An antimicrobial agent. SGTC_1514 1189-1591 158 µM 0.364902884842128 0.357232738278335 no 1198 0.357591950396276 414 767698 YMR146C TIF34 SGTC_1245 0418-0076 17.2 µM 0.364685726232098 0.357314394668826 no 1199 0.357673007349252 396 6790114 SGTC_2981 9013952 38.96 µM 0.364167957970711 0.357509113224551 no 1200 0.357866296211548 346 2996344 SGTC_1989 st071868 50.2 µM 0.364010018411932 0.357568517382124 no 1201 0.357925264127036 403 16414057 SGTC_1680 diphenhydramine 100 µM 0.363777972459499 0.357655800663045 no 1202 0.358011906368016 403 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_343 4130-2827 29.8 µM 0.36240384309482 0.358172827100857 no 1203 0.358525134021168 363 1118244 SGTC_3345 9148410 3.559 µM 0.361397954542146 0.358551465187412 no 1204 0.358900988431472 394 4903596 SGTC_1814 st052110 31.539 µM 0.360488389924257 0.358893964636412 no 1205 0.359240968669736 396 674163 SGTC_2262 9014885 67.46 µM 0.360322436097657 0.358956467326341 no 1206 0.359303011504611 396 6457424 SGTC_2353 9059630 146.67 µM 0.359583049203841 0.359234986256271 no 1207 0.359579480803327 395 4779114 SGTC_523 1934-0222 13.7 µM 0.35837212560279 0.359691289447938 no 1208 0.360032424402917 427 1361595 SGTC_3280 9140961 49.47 µM 0.357676869850172 0.359953367885836 no 1209 0.360292572336883 383 4901226 SGTC_37 0566-0070 1.56 µM 0.355858803533243 0.36063900361004 no 1210 0.360973154431837 427 1626686 SGTC_3286 9117135 37.221 µM 0.355754510918642 0.360678348431718 no 1211 0.361012209116234 398 3438150 SGTC_34 0469-0683 81.75 µM 0.355304048913978 0.360848304029464 no 1212 0.361180911253431 384 3690923 SGTC_2009 4012297 12.05 µM 0.353273372293056 0.361614802321518 no 1213 0.361941753012896 371 45595307 SGTC_913 3487-1245 167 µM 0.352651466604718 0.361849657849458 no 1214 0.362174874255486 372 4016153 SGTC_3103 9120822 49.47 µM 0.35259196136823 0.361872132046535 no 1215 0.362197182464925 421 17141819 SGTC_255 tunicamycin 200.472 nM 0.352427409655002 0.361934283134612 no 1216 0.362258874498898 374 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_985 1493-0307 8.71 µM 0.352258970862876 0.361997906141455 no 1217 0.362322027542007 427 3278274 SGTC_973 1325-0077 65.9 µM 0.350204626313159 0.362774183323568 no 1218 0.363092567525719 420 2835149 SGTC_540 1187-0821 17.3 µM 0.348781342595112 0.363312332064808 no 1219 0.363626735676257 430 847520 SGTC_161 4065-0411 162.148 µM 0.347626833392 0.363749054512756 no 1220 0.364060225783293 397 1906281 YLR208W SEC13 SGTC_1301 naphtanilide LB 4.81 µM 0.347390015560294 0.363838658781518 no 1221 0.364149166639798 391 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2352 9027995 87.8 µM 0.346646973611883 0.364119850329362 no 1222 0.364428275819411 397 2997347 SGTC_1808 st050063 61.5 µM 0.346098004997991 0.364327645142564 no 1223 0.3646345313367 426 4011993 SGTC_3074 9116018 49.47 µM 0.345840419139235 0.364425159923876 no 1224 0.36473132361419 401 17027303 SGTC_1467 k284-1082 293 µM 0.34515158391486 0.364685976714392 no 1225 0.364990207539498 396 3334705 SGTC_1040 k898-0338 155 µM 0.344952312258402 0.36476143952853 no 1226 0.365065110996439 416 20969351 SGTC_3232 9132874 49.47 µM 0.344253360954382 0.365026169013838 no 1227 0.365327877801468 385 3784940 SGTC_2206 7254556 146.969 µM 0.343203706328556 0.365423849069437 no 1228 0.3657226082942 383 4398905 SGTC_2665 lovastatin 100 µM 0.342172669751705 0.365814616258131 no 1229 0.36611047579598 395 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_184 1494-0393 24.714 µM 0.340755701645588 0.366351880266144 no 1230 0.366643750790999 383 3090647 SGTC_905 2-aminofluorene 215 µM 0.339828827956207 0.366703459715087 no 1231 0.366992718474772 379 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1970 st070122 35.8 µM 0.33844358596743 0.367229114747981 no 1232 0.367514466539679 412 102928 SGTC_1920 st075728 45.7 µM 0.337476922212052 0.367596080268853 no 1233 0.367878703112281 425 3400306 SGTC_1315 1237-0019 3.69 µM 0.336574717615316 0.367938684871134 no 1234 0.36821875885559 403 825140 SGTC_1450 4112-4260 37.6 µM 0.335477302629166 0.368355560607315 no 1235 0.36863253179305 422 1633175 SGTC_2240 6690706 185.951 µM 0.335467984629483 0.368359100906253 no 1236 0.368636045735101 364 805876 SGTC_700 3453-2283 142 µM 0.335214845904094 0.368455283201631 no 1237 0.368731511928804 374 565664 SGTC_1774 st048371 48.465 µM 0.333781163437329 0.369000178909861 no 1238 0.369272349230828 395 4242727 SGTC_165 k038-0023 64.381 µM 0.333779548476591 0.36900079285221 no 1239 0.369272958599056 393 46368543 SGTC_1485 3909-9022 254 µM 0.332406297444806 0.369522967834252 no 1240 0.369791241986587 393 714516 SGTC_843 0310-0051 143 µM 0.331847980718288 0.369735335151838 no 1241 0.370002025930966 425 2065037 SGTC_1338 1486-1223 76 µM 0.329341751239449 0.370689120102225 no 1242 0.370948694880538 416 3444526 SGTC_2940 9060638 45.86 µM 0.328460357662726 0.371024737573598 no 1243 0.371281806541146 382 4027022 SGTC_2047 4141938 200 µM 0.32845892779509 0.371025282119078 no 1244 0.371282347020131 431 3807862 SGTC_971 1315-0384 26.7 µM 0.328088811256292 0.371166244609706 no 1245 0.37142225676298 416 6769120 SGTC_3163 9099914 49.47 µM 0.326451548972902 0.371790019037436 no 1246 0.372041370666677 435 16268368 SGTC_780 0109-0199 192 µM 0.325336761106014 0.372214930693502 no 1247 0.372463105741556 428 610414 SGTC_1763 st044482 94.5 µM 0.324980343423428 0.372350815432549 no 1248 0.372597974308878 414 88505 SGTC_2799 7812892 81.82 µM 0.323258649354443 0.373007437245345 no 1249 0.373249683633383 406 20205235 SGTC_543 3844-1095 191 µM 0.322850692758785 0.37316307839443 no 1250 0.373404159840602 411 4230703 SGTC_1933 st074711 15.9 µM 0.321179676597234 0.373800810233104 no 1251 0.374037116324057 421 17250958 SGTC_1372 2752-0194 270 µM 0.318679571170282 0.374755603297781 no 1252 0.374984753716483 403 823334 SGTC_2639 lactacystin 53 µM 0.318312434452736 0.374895878054023 no 1253 0.375123976570544 387 3870 A proteasome inhibitor. SGTC_256 clotrimazole 625 nM 0.318202986967146 0.374937698702166 no 1254 0.375165483580671 400 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_306 1672-3436 11.6 µM 0.317257988369703 0.375298850377288 no 1255 0.375523926184115 424 6797378 SGTC_1012 4112-3522 18 µM 0.317107887915128 0.375356224586084 no 1256 0.375580869921955 388 3112398 SGTC_1050 3232-1156 69.3 µM 0.316046896034352 0.375761855346268 no 1257 0.375983456545789 403 700529 SGTC_1279 0874-0590 65.2 µM 0.3145140975515 0.376348106235483 no 1258 0.376565305508744 413 3523074 SGTC_2840 9008771 71.43 µM 0.314462752769584 0.376367749070163 no 1259 0.376584800806488 377 2992978 SGTC_133 0724-0033 378.92 µM 0.3140907315219 0.376510081796953 no 1260 0.376726064384983 436 280309 SGTC_225 nsc-122657 1.016 µM 0.313793368857886 0.37662386274781 no 1261 0.376838990543749 410 275685 SGTC_533 1222-0222 6.71 µM 0.313729133333159 0.376648442826956 no 1262 0.376863385949059 427 3982874 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.313655025142871 0.376676801357523 no 1263 0.376891531411873 447 1273210 SGTC_2275 7947463 200 µM 0.313221502766113 0.376842708058153 no 1264 0.377056191470972 405 1225414 SGTC_262 fenpropimorph 62.5 µM 0.312380008126679 0.377164808465042 no 1265 0.377375870969642 413 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1206 3978-0017 132 µM 0.31038302165106 0.377929540329263 no 1266 0.378134851901132 420 3873677 SGTC_923 1900-2434 73.3 µM 0.309901863106956 0.378113868259048 no 1267 0.37831779297863 452 5910570 SGTC_2106 5357045 167.29 µM 0.309369570329831 0.378317817625111 no 1268 0.378520207562294 406 668842 SGTC_610 4215-0184 155 µM 0.309129439559653 0.378409835457605 no 1269 0.378611532828459 422 5605015 SGTC_811 0416-0114 265 µM 0.308478247163081 0.378659406319382 no 1270 0.378859224987906 422 6612453 SGTC_2096 5468907 200 µM 0.308462110000608 0.378665591564055 no 1271 0.378865363665734 415 759785 SGTC_2921 7974240 10.71 µM 0.308435469064269 0.378675802888836 no 1272 0.37887549811189 407 2979074 YDR527W RBA50 SGTC_2983 9022671 12.99 µM 0.307233660880885 0.379136537367271 no 1273 0.37933276301231 441 6405161 SGTC_2063 5246145 200 µM 0.306147171403435 0.37955321021883 no 1274 0.379746296720935 419 711240 SGTC_1458 k015-0034 6.33 µM 0.305866231706935 0.379660974448742 no 1275 0.37985324886217 414 3598957 SGTC_351 caspofungin 25 nM 0.305853693357154 0.379665784188553 no 1276 0.379858022354771 400 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_236 1509-0011 5.31 µM 0.30574981461267 0.379705633029881 no 1277 0.379897570880229 430 3107280 SGTC_1313 1220-0047 237 µM 0.305455685561326 0.379818470566498 no 1278 0.380009557966587 407 3528706 SGTC_633 0437-0093 97.7 µM 0.305245201149696 0.379899225562539 no 1279 0.380089704258597 408 2831118 SGTC_2512 diallyl trisulfide 49.23 µM 0.30483777376285 0.380055555089716 no 1280 0.380244855288813 444 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2384 9036245 200 µM 0.304425765075827 0.380213662389045 no 1281 0.38040177050529 407 6462766 SGTC_2707 st078556 66.6 µM 0.303485231584332 0.38057466472338 no 1282 0.380760050295936 402 17250899 SGTC_2225 6654152 15.4 µM 0.303405598659362 0.380605234786525 no 1283 0.380790389767122 427 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1340 1486-1359 257 µM 0.303063012050634 0.380736757911974 no 1284 0.380920920726902 415 4309068 SGTC_3085 9117376 49.47 µM 0.302576840825997 0.38092342855772 no 1285 0.381106182975235 406 16480349 SGTC_2851 9015922 71.43 µM 0.301211795108367 0.381447700514663 no 1286 0.381626498031973 446 2996893 SGTC_3152 9099253 49.47 µM 0.300745456292316 0.381626856786922 no 1287 0.38180430167903 408 25236131 SGTC_2324 6149169 200 µM 0.300703661842823 0.381642914458433 no 1288 0.381820238104194 439 2888231 SGTC_2110 5483698 200 µM 0.300407053198184 0.381756879082106 no 1289 0.381933342163871 378 2848765 YHR062C RPP1 SGTC_2304 7443016 91.4 µM 0.299572849811403 0.382077456268798 no 1290 0.382251498121889 413 939854 SGTC_578 3460-0051 92 µM 0.299264849830057 0.382195838464217 no 1291 0.382368986023326 450 2876744 SGTC_2196 6573537 42.6665 µM 0.298237482122933 0.382590794835865 no 1292 0.382760958052481 432 2903087 SGTC_832 4083-0019 164 µM 0.295058020700453 0.383813864191821 no 1293 0.383974778714536 386 1990758 SGTC_1361 1608-0041 5.61 µM 0.29466495987175 0.383965146800416 no 1294 0.384124916612568 420 X1361 SGTC_1156 4092-0367 4.88 µM 0.294260161434789 0.384120965503578 no 1295 0.384279556115023 435 1357585 SGTC_244 nsc-207895 1.295 µM 0.294027444452764 0.38421055352642 no 1296 0.384368466079462 412 42640 SGTC_3323 9138564 53.9225 µM 0.292990892622057 0.384609665362692 no 1297 0.384764556510347 393 43912313 YNL103W MET4 SGTC_3238 9133470 49.47 µM 0.29267297045677 0.384732102008874 no 1298 0.384886066050862 428 3534688 SGTC_1606 st000094 49.2 µM 0.291931604201815 0.385017658038716 no 1299 0.385169459413538 426 1242210 SGTC_1775 st081588 35.1725 µM 0.291590248732595 0.385149160741719 no 1300 0.385299965988625 408 1426443 YGL099W LSG1 SGTC_137 0438-0332 85.389 µM 0.291361852610428 0.385237154719207 no 1301 0.385387293349003 436 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2000 st075254 36.4 µM 0.288296595594212 0.386418673768362 no 1302 0.386559856452729 396 17234175 SGTC_597 k018-0003 82.8 µM 0.287921577534672 0.386563298977075 no 1303 0.386703384751843 435 6786234 SGTC_501 nsc-95397 161 µM 0.286407977535022 0.387147176727152 no 1304 0.387282832662794 432 262093 SGTC_2904 7225135 42.03 µM 0.286359118884303 0.387166028425794 no 1305 0.387301541297169 446 4446116 SGTC_3176 9106582 49.47 µM 0.285452816735233 0.387515765681793 no 1306 0.387648623994527 403 17018027 SGTC_1983 st071813 46.9 µM 0.285181143992942 0.387620620569928 no 1307 0.387752682861013 419 11838595 SGTC_1207 2099-0101 141 µM 0.284663727673131 0.387820345384642 no 1308 0.387950891234871 414 5837381 SGTC_3341 9147222 25.867 µM 0.282881113182321 0.388508668848896 no 1309 0.38863398650149 422 1939759 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.282514965722504 0.388650093317282 no 1310 0.38877433639146 393 94937 An inhibitor of serotonin biosynthesis. SGTC_1912 st060209 90.8 µM 0.281535879660816 0.389028337797828 no 1311 0.389149706241584 454 688787 SGTC_2431 5490079 200 µM 0.281474663434381 0.389051990595591 no 1312 0.389173179249223 431 5722345 SGTC_71 0417-1750 47.813 µM 0.27961278490188 0.389771581466325 no 1313 0.389887298641107 439 6811472 SGTC_754 3474-0146 171 µM 0.279564823391331 0.389790122945917 no 1314 0.389905699095189 387 24762078 SGTC_2859 9028643 45.46 µM 0.279475815925635 0.389824533079476 no 1315 0.389939847501322 417 17151580 SGTC_2932 9016711 44.54 µM 0.279404016879276 0.389852291096897 no 1316 0.389967394382607 412 7117328 SGTC_407 eburnamonine 100 µM 0.277037517397289 0.390767510082999 no 1317 0.39087564920836 401 3195 SGTC_2287 7945887 168.79 µM 0.275639495472777 0.391308465289468 no 1318 0.391412485672432 426 1245853 SGTC_2065 5221596 34.26 µM 0.275495879299451 0.391364048533878 no 1319 0.391467645612627 390 788581 SGTC_2964 9083345 53.42 µM 0.275422244486587 0.391392548007652 no 1320 0.391495928036128 433 17741579 SGTC_730 1436-0052 41.2 µM 0.275052237731346 0.391535763520308 no 1321 0.391638052752288 402 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_567 1080-0542 68.4 µM 0.274443541481398 0.391771398620281 no 1322 0.391871892870383 418 5950415 SGTC_121 0557-0495 61.343 µM 0.273950888465616 0.391962140789755 no 1323 0.392061181786658 453 3104427 SGTC_1277 0873-0036 22 µM 0.273337428325639 0.392199692567244 no 1324 0.392296923360772 413 5965735 SGTC_514 4466-0038 2.65 nM 0.272006046543007 0.392715385146166 no 1325 0.392808685055363 401 5722064 SGTC_2960 9079389 5.97 µM 0.271196574623947 0.393029015207886 no 1326 0.393119923676598 422 16457355 SGTC_394 menadione 8.33 µM 0.271159519300949 0.393043373964303 no 1327 0.393134172932846 442 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3299 9121982 43.1275 µM 0.270700509605867 0.393221250035954 no 1328 0.393310692415628 411 17594604 YPL160W CDC60 SGTC_2636 apigenin dimethyl ether 100 µM 0.269725182541902 0.393599284097463 no 1329 0.393685842737484 430 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3271 9137798 49.47 µM 0.266017813751514 0.395037162447602 no 1330 0.395112744892914 416 6498326 SGTC_3011 9081274 71.4286 µM 0.264716472690249 0.395542219155766 no 1331 0.395613943346789 413 6625322 SGTC_2886 9058944 51.95 µM 0.264696041884684 0.395550149850706 no 1332 0.395621813445492 425 4949929 SGTC_965 1291-5240 308 µM 0.264237063803172 0.395728324319921 no 1333 0.39579862643827 427 2834598 SGTC_2720 fluspirilene 36.88 µM 0.26256293268025 0.396378403471687 no 1334 0.396443736638755 425 3396 An atypical antipsychotic. SGTC_3057 9095946 49.47 µM 0.262319526073792 0.396472944337257 no 1335 0.396537554671815 426 24540043 SGTC_1575 cyproterone acetate 48 µM 0.26139727039074 0.396831210218768 no 1336 0.396893080899012 438 9880 An androgen receptor antagonist and liver toxin. SGTC_740 k014-0057 261 µM 0.26127424726463 0.396879007231932 no 1337 0.396940512354744 455 4012779 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.259445625836367 0.39758964652425 no 1338 0.397645715092455 425 15053 SGTC_1613 st002381 52.1 µM 0.259329379533426 0.397634833708812 no 1339 0.397690556490188 409 551167 SGTC_3215 9129942 49.47 µM 0.257245418376262 0.39844514216202 no 1340 0.398494662305647 463 17682944 SGTC_2105 5350118 200 µM 0.25610452143019 0.398888943916245 no 1341 0.398935065396396 428 2133313 SGTC_2780 5215298 71.43 µM 0.255185773679361 0.399246426099889 no 1342 0.399289809188182 428 2834131 SGTC_3233 9132340 49.47 µM 0.253903908049058 0.399745337583204 no 1343 0.399784897762309 451 17682950 SGTC_796 1234-0020 70.7 µM 0.253865785974518 0.399760177484494 no 1344 0.39979962393267 397 46495034 SGTC_509 pifithrin 175 µM 0.252387759819594 0.400335644861305 no 1345 0.400370680114914 439 4817 A p53 inhibitor. SGTC_1829 berberine 14.4 µM 0.251821837018471 0.400556043467652 no 1346 0.400589388816514 438 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_364 0083-0097 67.7 µM 0.251258390012476 0.400775509334216 no 1347 0.400807171679429 405 5207356 SGTC_2801 7907800 81.82 µM 0.250794216079188 0.400956331299062 no 1348 0.400986606799439 456 6620925 SGTC_1974 st069448 26.9 µM 0.248434230107601 0.401876006576327 no 1349 0.401899225876877 437 6323587 YNR016C ACC1 SGTC_2277 7947813 106.88 µM 0.246706964794519 0.402549458481277 no 1350 0.402567508012214 448 1246798 SGTC_3111 9122088 49.47 µM 0.245346551368067 0.403080080480061 no 1351 0.403094055084736 454 16876704 SGTC_1556 plumbagin 1.48 µM 0.244405725787931 0.403447148964208 no 1352 0.403458303843364 440 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1341 1486-1360 280 µM 0.244049820709516 0.403586029563834 no 1353 0.403596117425915 457 3976547 SGTC_1737 st035557 69.7 µM 0.242205855860986 0.404305772309357 no 1354 0.404310328900898 437 5716916 SGTC_3203 9113543 49.47 µM 0.240419149548745 0.405003474821809 no 1355 0.405002667149245 407 17018012 SGTC_2056 5235370 200 µM 0.238594780518338 0.405716196185434 no 1356 0.405709906400691 414 5511916 SGTC_2985 9022375 71.43 µM 0.238356450031 0.40580932725987 no 1357 0.405802320953829 420 4939335 SGTC_3086 9117350 49.47 µM 0.238339062136806 0.405816122038972 no 1358 0.405809063454452 434 2679265 SGTC_115 0527-0192 112.043 µM 0.23566077046036 0.406863072879006 no 1359 0.40684795659831 460 4233931 SGTC_1330 1469-0054 61.8 µM 0.23556571080613 0.406900244214494 no 1360 0.406884841758256 459 7102664 SGTC_2466 5983409 37.09 µM 0.233271445314068 0.407797628319077 no 1361 0.407775315173813 449 2879657 SGTC_2223 6903751 107.57 µM 0.232466314295877 0.408112664016795 no 1362 0.408087923953421 448 5598863 SGTC_393 acivicin 6.25 µM 0.231473233860339 0.408501323314868 no 1363 0.408473588562433 448 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2493 resveratrol 26.09 µM 0.230860974856967 0.408740986403052 no 1364 0.408711404674831 440 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1473 k844-0725 134 µM 0.230626771052016 0.408832672331927 no 1365 0.408802383955424 437 54682906 SGTC_1765 st044815 90.4 µM 0.229826613168167 0.409145955147632 no 1366 0.409113251941397 439 645695 SGTC_882 0843-0131 351 µM 0.228844416733989 0.409530590166177 no 1367 0.409494921560396 448 5425421 SGTC_1717 st033143 58.0435 µM 0.228092064323485 0.409825275581366 no 1368 0.409787334629 461 674616 SGTC_2857 9024691 58.44 µM 0.227161547118098 0.410189815987309 no 1369 0.41014906352227 464 16478292 SGTC_2756 carbadox 75.1 µM 0.227133974175454 0.410200619178193 no 1370 0.410159783385177 427 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2967 9089538 49.85 µM 0.226876723524676 0.410301414310663 no 1371 0.410259801033579 435 728216 SGTC_895 0964-0006 13.7 µM 0.225938564832119 0.410669050830855 no 1372 0.410624601427439 455 6738897 SGTC_1492 4158-0558 28.5 µM 0.225420801034823 0.410871980717346 no 1373 0.410825965574332 464 3967268 SGTC_1334 1486-0610 236 µM 0.224503420875788 0.411231592894982 no 1374 0.411182802687621 428 3742339 SGTC_2742 clothiapine 36.27 µM 0.223241541733586 0.411726370184688 no 1375 0.411673761005295 461 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1157 4092-0394 27.6 µM 0.222606517468175 0.411975413571476 no 1376 0.411920881759541 412 3659885 SGTC_1160 4092-0570 10.5 µM 0.221626059097038 0.412359998673638 no 1377 0.412302497349878 456 4994975 SGTC_823 0417-1665 178 µM 0.219754675654601 0.413094282755807 no 1378 0.413031110151053 459 3429856 SGTC_2349 9023730 187.07 µM 0.217083529486075 0.414142900023371 no 1379 0.414071624740579 439 4126287 SGTC_2567 aureobasidin a 60 nM 0.215520202789931 0.414756902923582 no 1380 0.414680881293586 433 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_994 3910-0338 138 µM 0.214173906784989 0.41528583314444 no 1381 0.415205721667583 459 3479481 SGTC_254 nsc-64875 3.808 µM 0.213171286165424 0.415679840652496 no 1382 0.415596681923791 462 56993 SGTC_2237 6667747 47.222 µM 0.213020946060515 0.415738928275028 no 1383 0.415655312514264 473 729940 YDL015C TSC13 SGTC_2970 9090938 41.86 µM 0.21125683539624 0.416432412235462 no 1384 0.41634343156232 428 17217104 SGTC_673 1082-0474 110 µM 0.211195470428539 0.416456539919152 no 1385 0.416367372559116 462 3098046 SGTC_3048 9093155 49.47 µM 0.21082919943179 0.416600558120856 no 1386 0.416510276383381 464 25236002 SGTC_3064 1327-0027 10 µM 0.209152404379446 0.417260018636091 no 1387 0.417164633223556 471 16000455 YPR107C YTH1 SGTC_3063 1327-0034 4 µM 0.208911233402972 0.41735488707106 no 1388 0.417258767331118 472 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_326 k292-0812 17.5 µM 0.206012692623291 0.418495448993152 no 1389 0.418390498343172 462 3579357 SGTC_1113 artemisinin 1.17947 µM 0.205036590157089 0.418879695433766 no 1390 0.418771768732399 459 2240 An anti-malaria and mitochondrial poison. SGTC_2881 9058953 51.95 µM 0.204925594274316 0.418923394292165 no 1391 0.418815129105018 445 17122249 SGTC_1724 st037281 8.293 µM 0.204377191752185 0.41913931394555 no 1392 0.419029376180039 437 574124 YDL195W SEC31 SGTC_1274 0865-0114 173 µM 0.204175244987817 0.419218831526806 no 1393 0.419108277755731 419 870624 SGTC_993 3909-8757 62.7 µM 0.203401116728472 0.419523679065776 no 1394 0.419410763515477 420 4288324 YLR208W SEC13 SGTC_2724 maprotiline 69.64 µM 0.200898106939048 0.420509680545572 no 1395 0.420389123990642 467 4011 A tricyclic antidepressant. SGTC_162 k030-0015 37.8 µM 0.20028966818458 0.420749436219249 no 1396 0.420627021216308 449 1809920 YMR134W ERG29 SGTC_2832 7992762 51.95 µM 0.199420082681439 0.42109214794762 no 1397 0.420967076130153 387 2985177 SGTC_1609 st001574 46.4 µM 0.199116587606834 0.42121177226759 no 1398 0.421085772997525 489 3960012 SGTC_1803 st050068 52.4 µM 0.198665034694035 0.42138976788972 no 1399 0.421262388530607 459 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1916 st067606 49.2 µM 0.197090230904969 0.422010658235753 no 1400 0.421878464050874 450 19590279 SGTC_1800 st050079 29.0735 µM 0.196477298024969 0.422252368850099 no 1401 0.422118299956376 462 3645560 SGTC_2455 5377712 9.75 µM 0.196147766521508 0.422382331995288 no 1402 0.422247255035072 413 2243908 SGTC_2377 9073351 62.6 µM 0.193921187320806 0.423260688032886 no 1403 0.423118796759568 457 7337946 YHR072W ERG7 SGTC_2160 5660466 132.927 µM 0.193394853186549 0.423468375803094 no 1404 0.423324872956532 472 2859134 SGTC_3105 9121040 49.47 µM 0.193310777944494 0.423501553277088 no 1405 0.423357792975353 469 41448907 SGTC_1513 0337-0559 19 µM 0.192902372493755 0.423662724500525 no 1406 0.423517713475582 439 775073 SGTC_1967 st070177 51.4 µM 0.192002648149342 0.42401783254566 no 1407 0.423870065548322 481 5729214 SGTC_2211 7117706 200 µM 0.190706342120415 0.424529574006238 no 1408 0.424377834797462 474 822771 SGTC_258 haloperidol 50.781 µM 0.189623358878475 0.424957199834417 no 1409 0.424802140782445 487 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2444 5485484 36.41 µM 0.189365837321432 0.425058897590512 no 1410 0.424903048942425 459 6790631 SGTC_1306 1185-0270 9.02 µM 0.188401622202052 0.425439719719287 no 1411 0.425280914067643 469 1548076 SGTC_1137 ixabepilone 100 µM 0.186866137270678 0.426046311511777 no 1412 0.425882795013828 452 154225 A novel microtubule stabilizer. SGTC_1510 1123-0200 71.5 µM 0.186373004760725 0.426241160218887 no 1413 0.426076130305791 461 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1161 k007-0610 110 µM 0.185280027422859 0.426673086394171 no 1414 0.426504701308869 468 5843850 SGTC_845 0330-0138 4.51 µM 0.185234167541165 0.426691211370593 no 1415 0.42652268548142 483 9039800 SGTC_1307 1187-1599 12.2 µM 0.183635616786223 0.42732309523471 no 1416 0.42714966004341 466 1538471 SGTC_1470 k295-0292 231 µM 0.182323650769461 0.427841835738477 no 1417 0.427664369557697 479 5045612 SGTC_3124 9127567 49.47 µM 0.18042692514248 0.428592005667559 no 1418 0.428408708983696 460 17592030 SGTC_1013 4112-3890 241 µM 0.178172735022789 0.429483891034409 no 1419 0.429293660700358 438 705171 SGTC_1944 st076371 56.9 µM 0.177233290568407 0.429855695061705 no 1420 0.429662573737801 482 24208455 SGTC_197 4544-0043 41.561 µM 0.176712838210816 0.430061701346922 no 1421 0.429866978074527 459 896523 SGTC_2586 curcumin 80 µM 0.176552861597823 0.430125027374345 no 1422 0.42992981164672 441 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2201 6605497 169.863 µM 0.174865023822443 0.430793259626569 no 1423 0.430592846860384 476 670741 SGTC_3258 9138477 49.47 µM 0.174338378667263 0.43100180449263 no 1424 0.430799769617682 459 4970355 SGTC_1879 gemcitabine 100 µM 0.174125562829106 0.431086082352739 no 1425 0.430883391919885 460 60750 A nucleoside analog which inhibits DNA replication. SGTC_2227 7312221 64.1025 µM 0.173752185605843 0.431233952204986 no 1426 0.431030111526338 481 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2280 7785178 200 µM 0.172764507590325 0.431625152108619 no 1427 0.431418268158555 444 2954328 SGTC_1465 k213-0056 144 µM 0.171777695700011 0.432016075939694 no 1428 0.431806150556322 465 24048857 YMR208W ERG12 SGTC_2430 5571206 200 µM 0.170991692126383 0.432327497554421 no 1429 0.432115149056835 488 1731771 SGTC_676 falcarinol 140 µM 0.17073376056762 0.432429701507345 no 1430 0.432216557738155 478 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_293 4049-0273 38.5 µM 0.170708882137815 0.432439559686684 no 1431 0.432226339207741 457 1380311 SGTC_1084 voriconazole 435 nM 0.169591024394431 0.432882558689967 no 1432 0.432665890895707 496 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3318 9139014 38.6185 µM 0.169429735359402 0.432946483354771 no 1433 0.432729318082631 489 16643984 SGTC_2040 5100729 123 µM 0.168081951372322 0.433480727222549 no 1434 0.43325940402965 478 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_355 1311-2252 105 µM 0.167625063923663 0.4336618590441 no 1435 0.433439126015867 473 5338538 SGTC_850 0388-0143 75.9 µM 0.167619830888609 0.433663933747794 no 1436 0.433441184570805 448 67273 SGTC_2950 9072895 21.46 µM 0.167496054054271 0.433713007190032 no 1437 0.433489876040536 435 17332245 SGTC_1014 4130-3005 69.3 µM 0.166767596653317 0.434001837259673 no 1438 0.433776457857861 445 743608 SGTC_1299 1079-1439 3.74 µM 0.166188894003211 0.43423131537253 no 1439 0.434004149607314 457 323161 SGTC_2928 9011484 9.79 µM 0.165352208337186 0.434563132955471 no 1440 0.434333384005048 472 2994751 SGTC_2827 7993847 71.43 µM 0.164893171876171 0.434745199858122 no 1441 0.434514033443576 482 2985692 SGTC_841 0251-0215 91.2 µM 0.164534011184208 0.434887662844893 no 1442 0.434655387258958 489 3888614 SGTC_51 1013-0126 23.419 µM 0.16309482533377 0.435458608143924 no 1443 0.435221887016251 496 1627850 SGTC_2043 5101342 149 µM 0.162926853975073 0.435525253539999 no 1444 0.435288013457095 462 678451 SGTC_1932 st074806 40.9 µM 0.160778804493676 0.436377688264943 no 1445 0.436133809800514 482 17251235 SGTC_2996 9066192 71.4286 µM 0.16029603281721 0.436569312819585 no 1446 0.436323941910887 462 6472854 SGTC_2474 5321570 43.32 µM 0.160257585916184 0.43658457402874 no 1447 0.436339084257559 493 2841384 SGTC_2307 7538926 6.34 µM 0.157090195989286 0.437842167841344 no 1448 0.43758688205969 476 96582 SGTC_2252 omeprazole 400 µM 0.156184346649623 0.43820194612873 no 1449 0.437943857439938 490 4594 A proton pump inhibitor. SGTC_1445 4239-0156 97.7 µM 0.156176254619968 0.438205160289598 no 1450 0.43794704655959 486 4008346 SGTC_920 mycophenolic acid 780.421 nM 0.155624083657327 0.438424492670471 no 1451 0.438164670109821 462 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_204 PMA1.184 62.41 µM 0.155366983911593 0.438526623837918 no 1452 0.438266005545452 464 2252213 YGL008C PMA1 SGTC_1437 4092-1038 11.6 µM 0.155219762364104 0.438585108464164 no 1453 0.438324034495689 482 3977136 SGTC_1001 4048-4355 44.4 µM 0.154827011890607 0.438741137459049 no 1454 0.438478847786895 476 21824233 SGTC_1327 1436-0082 2.18 µM 0.15422521570712 0.438980233045144 no 1455 0.438716080391651 467 15992205 SGTC_3199 9111318 49.47 µM 0.153632865921362 0.439215597292336 no 1456 0.438949610658792 471 8548020 SGTC_919 tnp00227 403.569 nM 0.153326600288119 0.439337297304082 no 1457 0.439070362344967 476 1269246 A methoxyflavone. YNL221C POP1 SGTC_2019 4016004 108 µM 0.152116171202711 0.439818338497733 no 1458 0.439547654929738 458 45595336 SGTC_1923 st058458 19.1 µM 0.151445119799214 0.440085061903635 no 1459 0.439812299718651 492 3534982 SGTC_1748 st037455 53.6035 µM 0.149618073079055 0.440811397271218 no 1460 0.440532974218055 479 580690 SGTC_2339 9000433 200 µM 0.148898284396297 0.441097601305586 no 1461 0.440816947488759 458 2988954 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.148792971625926 0.441139478595459 no 1462 0.440858498366405 501 140250 A respiratory chain inhibitor. SGTC_1834 st055981 52.8 µM 0.148457333097266 0.441272948583216 no 1463 0.440990928010648 491 471719 YDL150W RPC53 SGTC_1107 amlodipine 47 µM 0.14749582033471 0.441655340535287 no 1464 0.441370339270086 485 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1304 1165-0502 251 µM 0.147318052910933 0.4417260442979 no 1465 0.441440491889846 466 767425 SGTC_1734 st037168 69.4 µM 0.146325322064214 0.442120919029011 no 1466 0.441832288439598 448 708907 SGTC_385 1494-0393 12.4 µM 0.145912267588444 0.442285235086925 no 1467 0.441995323552729 476 3090647 SGTC_2565 isoliquiritigenin 100 µM 0.143789411400214 0.443129878687279 no 1468 0.442833382230838 476 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2140 5586273 200 µM 0.143161877438722 0.44337961203968 no 1469 0.443081168513678 486 854421 SGTC_1455 4262-0120 131 µM 0.14177514895859 0.443931553992574 no 1470 0.443628807009596 457 1529587 SGTC_3031 9088762 49.47 µM 0.141435892367546 0.444066600592839 no 1471 0.443762800621594 453 205253 SGTC_2492 derrusnin 100 µM 0.140536055266633 0.444424826794532 no 1472 0.444118233584183 490 1715307 Part of coumarin class of compounds. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.13907294236902 0.445007390550693 no 1473 0.444696254640144 466 115019 SGTC_2036 5160441 105 µM 0.139053807097225 0.445015010380465 no 1474 0.444703815050575 464 134534 YIL048W NEO1 SGTC_2099 5377090 177.372 µM 0.13903083847945 0.445024156708397 no 1475 0.444712890055498 466 2243829 SGTC_2012 4023501 200 µM 0.137684420448162 0.445560364500364 no 1476 0.44524491640162 487 3477460 SGTC_2880 9042983 58.44 µM 0.137492705417512 0.445636722680527 no 1477 0.445320679111165 468 6464714 SGTC_483 fpl-64176 144 µM 0.137479295625358 0.445642063742179 no 1478 0.445325978521011 492 3423 SGTC_2314 7727897 200 µM 0.136156591928051 0.4461689391724 no 1479 0.445848745070693 477 900724 SGTC_732 3970-1727 52.7 µM 0.134182062451555 0.446955634372287 no 1480 0.446629304861668 499 1275699 SGTC_3137 9097352 49.47 µM 0.133225339931181 0.447336888571023 no 1481 0.447007585553688 492 44120435 SGTC_403 arphamenine a 50 µM 0.131782841600358 0.447911816466614 no 1482 0.447578029297471 497 5487158 An arginine aminopeptidase inhibitor. SGTC_1665 st014639 11.4 µM 0.130274013335642 0.448513298174247 no 1483 0.448174819596698 494 981133 YIL048W NEO1 SGTC_3043 9092303 49.47 µM 0.130238891959103 0.448527300430919 no 1484 0.448188712637574 461 25236084 SGTC_479 n-linoleoylglycine 10 µM 0.128483624780609 0.449227174983438 no 1485 0.44888312817315 492 6433346 An anti-infammatory. SGTC_3281 9140613 49.47 µM 0.126077501304081 0.450186820620313 no 1486 0.449835288350429 454 16013766 SGTC_2244 6635614 200 µM 0.125465058221786 0.450431130937007 no 1487 0.450077692956327 471 836499 SGTC_3197 9113331 49.47 µM 0.125014595932327 0.450610837318911 no 1488 0.450255997555067 457 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3180 9109287 49.47 µM 0.124815325838072 0.450690336901076 no 1489 0.450334877006316 482 18891271 SGTC_3270 9137563 49.47 µM 0.123285394148696 0.451300774790463 no 1490 0.45094055318872 503 17015724 SGTC_2740 felodipine 17.08 µM 0.121715214066303 0.451927391419694 no 1491 0.451562281872136 505 3333 L-type calcium channel blocker SGTC_772 k072-0172 35.3 µM 0.120301987766449 0.452491474480438 no 1492 0.452121964769984 447 5861980 SGTC_1357 1503-1303 39.5 µM 0.120239935927409 0.452516244405176 no 1493 0.452146541475492 488 292895 SGTC_1604 st002052 72.4 µM 0.118572680523836 0.453181850221808 no 1494 0.452806955205267 478 6254834 YHR062C RPP1 SGTC_23 0213-0011 39.996 µM 0.117704527777797 0.453528488507682 no 1495 0.453150889537614 486 627608 SGTC_2628 lathosterol 100 µM 0.117698374451914 0.453530945550325 no 1496 0.453153327414132 469 6710616 SGTC_983 1491-0821 12.2 µM 0.116939055479106 0.453834157660527 no 1497 0.453454174328672 478 46495113 SGTC_3277 9138724 49.47 µM 0.113934617555162 0.455034155409438 no 1498 0.454644811697309 506 15943418 SGTC_1955 wogonin 32.4 µM 0.113920465545996 0.455039808820576 no 1499 0.45465042101074 474 5281703 A flavanone. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.112989319109675 0.45541180095178 no 1500 0.455019511550456 458 4174840 SGTC_3195 9113082 49.47 µM 0.112782073333981 0.455494600776229 no 1501 0.455101665530021 516 17018038 SGTC_3339 9145883 14.936 µM 0.112040315515741 0.455790967227565 no 1502 0.455395720318463 504 2030670 SGTC_211 3455-0679 143.504 µM 0.111341340955034 0.456070262311222 no 1503 0.455672836923346 468 748649 SGTC_1039 k821-0043 94 µM 0.111154542356407 0.456144906663819 no 1504 0.455746899060851 485 15992768 SGTC_1994 st072947 40.9 µM 0.111062177350095 0.456181816110709 no 1505 0.455783520620191 497 5286565 YDL195W SEC31 SGTC_2946 9065502 71.43 µM 0.110284247505291 0.456492695136627 no 1506 0.456091974862209 475 16489101 SGTC_2553 4-methylesculetin 85.09 µM 0.10997238857423 0.456617328774558 no 1507 0.456215636397701 454 5319502 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.109271846505227 0.456897314194932 no 1508 0.456493438045504 470 5282362 SGTC_1776 st049249 45.9 µM 0.109080582848235 0.456973760202832 no 1509 0.45656928781157 502 1822314 SGTC_1181 1222-0449 220 µM 0.108839780831085 0.457070008419563 no 1510 0.4566647853426 479 658318 SGTC_1410 3909-8106 77.9 µM 0.107260305331972 0.457701384657912 no 1511 0.457291237286971 508 1039210 SGTC_1632 st005650 90 µM 0.10678692404374 0.45789063397157 no 1512 0.457479010627592 483 2759605 SGTC_291 SEC14.278 35.5 µM 0.105729510766128 0.458313403175442 no 1513 0.457898482686053 501 1068044 SGTC_2675 theaflavin digallate 100 µM 0.104582309801408 0.458772124127402 no 1514 0.458353626225545 502 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2524 avocatin b 10.57 µM 0.103796439736435 0.459086394661975 no 1515 0.458665445944037 514 6710748 SGTC_2708 st078559 56 µM 0.103531262649498 0.459192445128402 no 1516 0.458770669398043 513 17250902 SGTC_2576 guaiol 23.12 µM 0.103488556240766 0.459209524683299 no 1517 0.458787615762295 472 227829 SGTC_1392 3455-1037 33.9 µM 0.102053863497129 0.459783344260679 no 1518 0.459356960667333 501 981132 SGTC_1550 gossypolone 36.6 µM 0.100278119858868 0.460493686416239 no 1519 0.460061763873125 500 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_35 0133-0054 64.071 µM 0.100178457339601 0.4605335576909 no 1520 0.460101324259861 489 99677 SGTC_151 3013-0144 2.285 µM 0.0997912349920931 0.460688474741382 no 1521 0.460255033389104 506 906558 YHR107C CDC12 SGTC_2115 tiliquinol 12.7705 µM 0.0997792164809513 0.460693283113947 no 1522 0.460259804270073 504 71208 A bioactive hydroxyquinoline. SGTC_928 2764-0428 58.7 µM 0.0988396713441846 0.461069194581113 no 1523 0.46063278475858 509 662578 SGTC_2271 7849410 118.62 µM 0.0984431275635245 0.461227861978535 no 1524 0.460790215063243 502 972430 SGTC_3082 9117008 49.47 µM 0.0976994735023566 0.461525433775626 no 1525 0.461085466821183 501 41448529 SGTC_3139 9095020 49.47 µM 0.0974593208479484 0.461621535025526 no 1526 0.461180818827765 513 25236292 SGTC_1108 betulinic acid 729.144 nM 0.0963865610426508 0.462050845751548 no 1527 0.461606782580521 470 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1729 st035615 45.989 µM 0.095194348191492 0.462528012579657 no 1528 0.462080229545802 526 17385451 SGTC_2465 5809242 33.21 µM 0.0949170031559271 0.462639023880326 no 1529 0.462190375464428 510 2731748 SGTC_3217 9129673 49.47 µM 0.0948650445593017 0.462659821372571 no 1530 0.462211010832414 472 17248312 SGTC_2657 nystatin 74.44 µM 0.0942571019474953 0.462903170421073 no 1531 0.462452462916128 501 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1614 st002383 48.6 µM 0.0941507579064599 0.462945739554447 no 1532 0.462494700218985 506 1947235 SGTC_947 3447-0010 211 µM 0.0938587260738657 0.463062641017539 no 1533 0.46261069043346 490 748350 SGTC_140 0062-0056 502.533 µM 0.0937775362239218 0.463095142193135 no 1534 0.462642938264433 487 3758964 SGTC_3331 9141060 1.957 µM 0.0928800128318553 0.463454446886197 no 1535 0.462999442274082 476 4906567 YPR165W RHO1 SGTC_1241 0364-0022 50.8 µM 0.0911604382082422 0.464142925603173 no 1536 0.463682554876922 502 4563895 SGTC_881 0833-0569 170 µM 0.0910529486621608 0.464185965569321 no 1537 0.463725259400303 473 5418700 SGTC_2348 9022543 33.42 µM 0.0895894817547136 0.464771994889548 no 1538 0.464306721568748 520 3162678 YDL140C RPO21 SGTC_644 1498-1197 63.3 µM 0.0885848396995658 0.465174337130503 no 1539 0.464705928440058 495 6741615 SGTC_237 nikkomycin 200 µM 0.0884432757164581 0.465231033995572 no 1540 0.464762183494235 503 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2435 5706476 10.6 µM 0.0882871141043657 0.46529357808027 no 1541 0.464824240208176 506 5725375 SGTC_2676 harmalol 100 µM 0.0879732802070349 0.465419273878708 no 1542 0.464948956545041 485 5459187 A monoamine oxidase inhibitor SGTC_3336 9143619 71.43 µM 0.0871174044332944 0.465762084140107 no 1543 0.465289095622221 519 45595730 SGTC_2838 9002687 71.43 µM 0.0864710061504636 0.466021007685373 no 1544 0.465546001731133 494 6457060 SGTC_2942 9052777 62.25 µM 0.0862893977158167 0.466093755984779 no 1545 0.465618183218631 517 6469503 SGTC_2150 5556613 200 µM 0.0855632093401171 0.466384662193869 no 1546 0.465906822928583 490 743190 SGTC_160 3453-0671 289.699 µM 0.0853881771818902 0.466454781598456 no 1547 0.465976396038213 496 5322268 SGTC_976 1348-1067 47.6 µM 0.0850300826272563 0.46659824063272 no 1548 0.466118737414978 494 5310671 YGL099W LSG1 SGTC_313 3474-0040 5.03 µM 0.0847420286600098 0.466713643314869 no 1549 0.466233241041022 508 1043375 YIL048W NEO1 SGTC_2267 7931562 200 µM 0.0839756243354989 0.467020700473219 no 1550 0.466537906130487 495 934880 SGTC_2291 7917025 104.35 µM 0.0828949206926017 0.467453713842029 no 1551 0.466967546421165 512 2964612 SGTC_2592 piperlongumine 83.33 µM 0.0813268651455518 0.468082066385477 no 1552 0.467591004726774 507 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1316 1272-0050 65.9 µM 0.0805198760041807 0.468405474851265 no 1553 0.467911894396655 506 7340392 SGTC_714 4296-0578 26.1 µM 0.0802067359742787 0.468530974281769 no 1554 0.468036416445905 510 1589775 SGTC_761 k216-0224 480 µM 0.0797415574221094 0.468717413077608 no 1555 0.468221403314282 516 1340404 SGTC_2757 clomiphene 4.22 µM 0.0786413922701591 0.469158375219978 no 1556 0.468658931600311 519 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_285 1486-1325 46 µM 0.0784073743583272 0.469252177889799 no 1557 0.468752003851298 493 22310230 SGTC_684 1140-0066 328 µM 0.0773095850469029 0.46969223343478 no 1558 0.469188632982679 502 6813534 SGTC_1033 k072-0102 21.3 µM 0.0771873232413273 0.469741245126676 no 1559 0.469237263073751 512 5965931 SGTC_31 0508-1974 57.237 µM 0.0771442135415556 0.469758526833618 no 1560 0.469254410227768 511 6810525 SGTC_92 0063-0024 660.874 µM 0.0765826122698783 0.469983665318 no 1561 0.469477795861837 520 3594437 SGTC_1754 st042065 16.137 µM 0.0764001022504211 0.470056833228173 no 1562 0.46955039413052 505 1126236 YIL048W NEO1 SGTC_2723 salbutamol 83.58 µM 0.0752470772399704 0.470519101970492 no 1563 0.470009064138667 513 9884233 β2-adrenoceptor agonist SGTC_32 0928-0142 34.1 µM 0.0745179300989251 0.470811450895213 no 1564 0.470299137337616 514 2244242 SGTC_1079 idarubicin 2.36 µM 0.0724964842087157 0.471622024134185 no 1565 0.471103401651912 525 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_430 0958-0115 16.4 µM 0.0712514689622308 0.472121317603508 no 1566 0.471598809581462 493 6833180 SGTC_589 1227-0070 34.1 µM 0.0711176703862476 0.47217497800549 no 1567 0.471652052422201 521 2841384 SGTC_853 0419-0306 21 µM 0.0709977766178509 0.472223062263264 no 1568 0.471699762514471 518 762713 SGTC_1275 0867-0008 21.1 µM 0.0705105450642172 0.472418474138917 no 1569 0.471893653847068 512 3422836 SGTC_283 0987-0079 11.7 µM 0.0689799282683736 0.473032395041267 no 1570 0.472502798179272 519 411556 SGTC_1740 st038286 13.222 µM 0.0686648095311039 0.473158795212272 no 1571 0.472628214994879 511 716786 SGTC_1268 0828-0275 2.46 µM 0.0673220436024625 0.473697434527597 no 1572 0.473162664219759 499 745337 SGTC_2126 5251174 33.877 µM 0.0666504302970303 0.473966864688821 no 1573 0.473429998699277 498 790722 SGTC_708 3448-5400 146 µM 0.0665716347807991 0.473998475757674 no 1574 0.473461363900791 526 3462195 SGTC_1953 st076800 12.1 µM 0.0661783101370598 0.474156271601803 no 1575 0.473617932457838 502 297591 SGTC_1453 4237-0541 195 µM 0.0658352709199787 0.474293897011302 no 1576 0.473754487502353 513 739892 SGTC_489 paxilline 115 µM 0.065443008962632 0.474451274066781 no 1577 0.473910640625927 505 105008 A toxic potassium channel blocker. SGTC_143 4032-1194 15.74 µM 0.065195307835015 0.474550654798359 no 1578 0.474009248494053 506 1806963 SGTC_756 0508-1999 28.3 µM 0.0645960359271254 0.474791096578731 no 1579 0.474247820495893 511 6753853 SGTC_778 3456-2434 196 µM 0.0643813695034793 0.474877227961942 no 1580 0.474333282114831 515 5539063 SGTC_9 0092-0002 10.449 µM 0.0633144747624161 0.475305319326329 no 1581 0.474758044847939 515 759368 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0625264973733196 0.475621513474347 no 1582 0.475071780683137 518 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1132 3456-3614 2.5 µM 0.0609808125743124 0.476241799652677 no 1583 0.475687244980117 496 3125502 SGTC_454 lyso-paf C-16 6.67 µM 0.0586237474063293 0.477187804618671 no 1584 0.476625897756901 509 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2064 5220758 200 µM 0.0584174283970122 0.47727061667487 no 1585 0.476708066312642 520 788518 SGTC_1854 st056233 32.9 µM 0.0582672171677415 0.477330908880768 no 1586 0.476767890021477 516 5393174 SGTC_400 oxethazaine 37.5 µM 0.058128135675221 0.477386734264285 no 1587 0.47682328162491 513 4621 A local anesthetic. SGTC_3252 9135871 49.47 µM 0.0528461220923143 0.479507179778461 no 1588 0.478927256351173 517 17682838 SGTC_2101 5377231 179.231 µM 0.0516238668564684 0.479997934622929 no 1589 0.479414200845851 519 2844213 SGTC_2766 oltipraz 83.91 µM 0.0515260160180781 0.480037224605754 no 1590 0.479453185798456 517 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_664 1222-0054 14.9 µM 0.0509046380142673 0.480286730617787 no 1591 0.479700754851286 524 6813991 SGTC_991 3996-0057 64.7 µM 0.0503524356802774 0.480508466551206 no 1592 0.479920769549888 513 715343 SGTC_2409 alverine citrate 63.97 µM 0.049664941483804 0.480784537128981 no 1593 0.480194697304055 450 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_423 5-fluorouracil 457 µM 0.0486972913419225 0.481173122879192 no 1594 0.480580267256306 527 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0484324857486848 0.481279465768542 no 1595 0.480685784895598 536 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_465 cgp-37157 41 µM 0.0477482091768536 0.481554269542688 no 1596 0.480958456262892 519 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2659 sanguinarine 24.21 µM 0.047073030440069 0.481825428240429 no 1597 0.481227511046517 525 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1030 k029-0042 36.7 µM 0.0470689845821569 0.481827053123884 no 1598 0.481229123323164 486 6080581 SGTC_2860 9025725 38.96 µM 0.0466561834035782 0.481992842486815 no 1599 0.481393626433537 527 40546248 SGTC_2366 9070441 60.58 µM 0.0462029104217935 0.482174889736401 no 1600 0.481574261386386 519 6837235 SGTC_2589 lobaric acid 100 µM 0.0460203919875846 0.48224819535359 no 1601 0.481646998335803 524 73157 A novel microtubule depolymerizer. SGTC_1711 st032263 62.8 µM 0.0452729666956094 0.482548393032165 no 1602 0.481944867394717 512 3958979 SGTC_2135 5326629 150.42 µM 0.0451868765434618 0.482582971125091 no 1603 0.481979177283714 524 5020077 SGTC_2485 5633444 17.78 µM 0.0446864548566198 0.482783967984477 no 1604 0.482178615185989 528 5724239 SGTC_1832 st054113 55 µM 0.04402940824114 0.483047880661558 no 1605 0.482440481102518 526 1251267 SGTC_308 4092-1169 104 µM 0.043399519485694 0.483300891949903 no 1606 0.482691530368392 524 2268590 YDL196W YDL196W SGTC_3012 9080433 71.4286 µM 0.0427976042660336 0.483542673220932 no 1607 0.482931436880117 531 17688859 SGTC_1646 st011709 75.6 µM 0.0426726251428272 0.483592876420228 no 1608 0.482981250828366 533 5757843 SGTC_2786 7743617 45.45 µM 0.0420743411270405 0.483833206320725 no 1609 0.483219717433437 527 583674 SGTC_2468 5987765 72.9 µM 0.0419433495908927 0.483885826234939 no 1610 0.483271929404855 509 26772094 SGTC_3149 9097855 49.47 µM 0.041684491648923 0.483989811508274 no 1611 0.483375108543391 542 25236625 YMR079W SEC14 SGTC_3079 9117512 49.47 µM 0.0412659362546291 0.484157950806267 no 1612 0.483541944428929 529 7185044 SGTC_2629 bisabolol 100 µM 0.0408667185881649 0.484318324505699 no 1613 0.483701074995186 535 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1504 k297-0033 30 µM 0.04029481150496 0.484548075402016 no 1614 0.483929045120302 532 4388117 SGTC_2094 5332512 191.667 µM 0.0401108623038454 0.484621973978837 no 1615 0.484002370952917 530 755774 SGTC_960 1222-0186 7.7 µM 0.0382160419319737 0.485383217293806 no 1616 0.484757715313421 525 3126296 SGTC_181 1447-1644 8.07 µM 0.0380979791821184 0.485430650747338 no 1617 0.484804781260568 524 534600 SGTC_3319 9138450 16.7555 µM 0.0373653544469929 0.485724998138123 no 1618 0.485096848257757 538 2029690 SGTC_1229 0139-0193 12.2 µM 0.0365133257203731 0.48606732836461 no 1619 0.48543652670344 513 3090752 SGTC_1630 st005209 31.3 µM 0.0363432164771709 0.486135676518216 no 1620 0.48550434545944 532 3367314 SGTC_2935 9038016 29.96 µM 0.035719947769572 0.486386102973122 no 1621 0.485752832340426 537 6463195 SGTC_2957 9076800 11.52 µM 0.0346007466770041 0.48683580615373 no 1622 0.486199053047807 529 16459615 SGTC_2317 5986382 200 µM 0.0344261233254774 0.486905972617103 no 1623 0.486268676206677 539 877883 SGTC_889 0919-1524 82.7 µM 0.0338342041569879 0.487143818235463 no 1624 0.486504680289276 502 3905452 SGTC_2111 5486399 200 µM 0.0330149044620301 0.487473037677153 no 1625 0.486831351039391 530 689674 SGTC_2721 ifenprodil 61.44 µM 0.0322001815439682 0.487800426496994 no 1626 0.487156205702161 522 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3322 9139058 2.11 µM 0.0311432231848207 0.48822516759221 no 1627 0.487577659628096 504 4908926 YPR165W RHO1 SGTC_1230 0170-0365 3.77 µM 0.0293331947848653 0.488952562330504 no 1628 0.488299426338207 537 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2462 5162487 171.77 µM 0.0287363806716747 0.489192411739177 no 1629 0.488537420380086 535 2259986 SGTC_1721 st082152 9.2685 µM 0.0282801561221522 0.489375763241526 no 1630 0.488719353695101 533 5296051 SGTC_3188 9110789 49.47 µM 0.0279970958616662 0.48948952309972 no 1631 0.488832233703491 521 849217 SGTC_1369 1866-0067 208 µM 0.0278620077806462 0.489543814318098 no 1632 0.488886105035018 533 3531355 SGTC_2326 6164455 177.58 µM 0.0266032480747377 0.490049712674066 no 1633 0.489388091294399 525 2888790 SGTC_2555 cholic acid 100 µM 0.0263148174129348 0.490165635889251 no 1634 0.489503118208865 523 6708657 Influences liver metabolism. SGTC_1482 3346-2049 8.48 µM 0.0262752120642481 0.490181553746604 no 1635 0.489518912995564 534 3826804 SGTC_2543 pimpinellin 60.67 µM 0.0237520335428781 0.491195680131873 no 1636 0.490525200465001 530 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1300 1094-0077 113 µM 0.0214422552810558 0.492124085858924 no 1637 0.491446433232258 535 5532636 SGTC_2842 9000675 19.48 µM 0.0203907168312173 0.492546761783852 no 1638 0.491865844603902 542 2989072 SGTC_574 1315-0397 40 µM 0.0193055935823085 0.492982946208021 no 1639 0.492298660863887 541 6794277 SGTC_419 nsc-638432 893 µM 0.0188019521422247 0.49318539664815 no 1640 0.492499548257357 513 368090 SGTC_1163 k060-0048 49.9 µM 0.0183231491029503 0.493377864341294 no 1641 0.492690530125903 539 6809982 SGTC_2546 rhodinyl acetate 100 µM 0.0160789017448181 0.494280019430682 no 1642 0.493585722654439 531 6708682 SGTC_1422 4031-0024 15.5 µM 0.0159510219889486 0.494331426173962 no 1643 0.493636732753899 539 782427 SGTC_1883 5-benzylidenerhodanine 20 µM 0.0146180456489333 0.494867278532699 no 1644 0.494168451222487 535 1273210 SGTC_2356 9061756 188.97 µM 0.0144841799862021 0.494921092642122 no 1645 0.494221850241688 532 20104043 SGTC_170 4197-0004 226 µM 0.0130815421323228 0.495484959615194 no 1646 0.494781368592222 537 218692 SGTC_2933 9026794 32.47 µM 0.0127525857219149 0.495617202977179 no 1647 0.494912592264324 542 17586027 SGTC_2945 9067681 61.76 µM 0.0123152902368823 0.495793000340531 no 1648 0.495087034218024 541 16456930 SGTC_783 0848-0141 92.7 µM 0.0116224452373781 0.496071532943251 no 1649 0.495363419579228 537 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2571 chrysanthemic acid 100 µM 0.0107120930775872 0.496437509112126 no 1650 0.49572657488841 531 2743 An insecticide. SGTC_861 0443-0273 110 µM 0.0106868087548079 0.496447673859622 no 1651 0.495736661296444 527 6149169 SGTC_532 1548-0774 215 µM 0.0105787665316481 0.496491108781011 no 1652 0.495779761470871 536 5932993 SGTC_1158 4092-0494 91.8 µM 0.0100639545467868 0.496698073041881 no 1653 0.495985130796484 542 1148199 SGTC_2908 7930301 100 µM 0.00984586883292996 0.496785747939751 no 1654 0.496072130097387 545 2223178 SGTC_1396 3511-0007 98.6 µM 0.0095825833984173 0.496891594252191 no 1655 0.496177160832932 540 X1396 SGTC_1574 spiramycin 23.7 µM 0.0080565409685607 0.497505099655824 no 1656 0.496785939943515 542 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1011 4112-3381 17.4 µM 0.00798596607917147 0.497533472596199 no 1657 0.496814094345072 543 2877139 SGTC_1676 st018489 23.4 µM 0.00604890386546562 0.498312226343509 no 1658 0.49758685121387 546 3696235 SGTC_1280 0880-0253 10.1 µM 0.00604077830796126 0.498315493062857 no 1659 0.497590092783086 541 6836607 SGTC_2373 9071805 200 µM 0.00569336362151306 0.498455164354695 no 1660 0.497728688804213 541 10149009 SGTC_1317 1273-0028 910 nM 0.0051385185384197 0.498678229373308 no 1661 0.497950036717734 547 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1032 k061-1018 98.7 µM 0.00495814047983083 0.498750747067857 no 1662 0.498021996234692 534 4005393 SGTC_2301 7769476 200 µM 0.00461963138327798 0.498886838559332 no 1663 0.498157040276442 544 977820 SGTC_1806 st050005 60.3 µM 0.0035286258503898 0.499325458505059 no 1664 0.498592284877853 545 5194765 SGTC_1261 0712-0010 12.7 µM 0.00347394792665689 0.499347440846529 no 1665 0.498614098079728 546 2840123 SGTC_1539 benzyladenosine 56 µM 0.00332679451085274 0.499406601417041 no 1666 0.498672803459552 544 92208 A nucleotide analog. SGTC_1159 4092-0538 61.2 µM 0.00267700438351344 0.499667838811984 no 1667 0.49893203104217 548 717301 SGTC_668 1682-0499 62.6 µM 0.00194811088970287 0.499960878573782 no 1668 0.499222816690773 547 682214 SGTC_1367 1812-0510 76.9 µM 0.00175349327753052 0.499960878573782 no 1669 0.499300457751678 545 1142582 YDR527W RBA50 SGTC_3326 9140064 16.379 µM 0.0013552572417221 0.4998007742467 no 1670 0.499459330750967 546 1868434 SGTC_3235 9132602 49.47 µM 0.00129231054074393 0.499775467550695 no 1671 0.499484442829391 547 4912240 SGTC_2518 prenyletin 46.28 µM 0.000566374764182986 0.499483616985142 no 1672 0.499774049172095 548 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1184 1269-1718 139 µM 0.00052187609307785 0.499465727032097 no 1673 0.499791801570791 548 5403821 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.000763924525005833 0.498948792817356 no 1674 0.499695238237582 548 5357218 A potent inhibitor of glutathione S-transferases. SGTC_341 1486-1430 230 µM -0.00125915383509538 0.49874969474058 no 1675 0.499497670430389 548 2054753 YPL210C SRP72 SGTC_731 3966-0296 387 µM -0.00163382655113126 0.498599064488063 no 1676 0.499348197799897 550 660956 SGTC_1982 st072467 71.9 µM -0.00166060354796802 0.498588299297931 no 1677 0.499337515338209 550 3163533 SGTC_2541 muurolladie-3-one 83.07 µM -0.00208331911546757 0.498418354561429 no 1678 0.499168876522481 549 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3155 9099265 49.47 µM -0.00214325257243953 0.498394259479967 no 1679 0.499144966585879 548 25236499 SGTC_718 1130-0073 349 µM -0.00347628678340901 0.497858340660218 no 1680 0.498613165016515 551 6740020 SGTC_1771 st048882 4.1505 µM -0.00381774220832465 0.497721066155646 no 1681 0.498476944917221 550 4580403 SGTC_875 0709-0210 25.7 µM -0.00452704086441482 0.497435909401216 no 1682 0.49819397816288 551 6251364 SGTC_517 1365-0151 113 µM -0.00614432534295957 0.496785723546234 no 1683 0.49754878425951 553 768657 SGTC_1529 apigenin 74 µM -0.00851902993295213 0.495831053207241 no 1684 0.496601439879567 554 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.00933063972945209 0.495504777907022 no 1685 0.496277667320373 553 16486 A toxic proline analog. SGTC_2294 7971431 200 µM -0.00984781454289255 0.495296869985792 no 1686 0.496071353909048 555 5741572 SGTC_3183 9108214 49.47 µM -0.0105664477193917 0.495007976515249 no 1687 0.495784675691261 555 4974831 SGTC_2661 dactinomycin 12.96 µM -0.0106697503749642 0.494966448637672 no 1688 0.49574346621742 555 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3109 9122853 49.47 µM -0.0107380540707872 0.494938990443005 no 1689 0.495716218546229 564 1234709 SGTC_2082 5219693 150 µM -0.0110688498133484 0.49480601036848 no 1690 0.495584257983263 553 2834649 SGTC_1197 1601-0112 267 µM -0.012694482580355 0.494152513749766 no 1691 0.49493577018792 555 7350313 SGTC_1962 st076595 64.5 µM -0.0128551562560995 0.494087924522009 no 1692 0.494871675895567 555 279619 SGTC_1121 fusaric acid 630.51 nM -0.0151404884760677 0.49316926117114 no 1693 0.493960049762567 558 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3028 9087778 49.47 µM -0.0153329886909611 0.493091881057405 no 1694 0.493883262201926 553 17217395 SGTC_209 4077-0173 175.592 µM -0.0154066805608322 0.493062258897964 no 1695 0.493853866871581 545 15993494 SGTC_556 4058-0063 51.5 µM -0.0159710813537564 0.492835386165121 no 1696 0.493628731244437 556 6615692 SGTC_2471 5466956 24.79 µM -0.0165756815218693 0.492592357023481 no 1697 0.493387562613919 560 724419 SGTC_2591 skatole 100 µM -0.018404066508205 0.491857424223157 no 1698 0.492658254194272 555 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2155 5570423 76 µM -0.0194941964296414 0.491419251471993 no 1699 0.492223433371481 563 797402 SGTC_1253 0550-0034 176 µM -0.0203262748563443 0.491084808282244 no 1700 0.491891547905153 562 5969915 SGTC_1478 0453-0656 35.7 µM -0.0207780946520069 0.490903207754486 no 1701 0.491711335951163 554 5258496 SGTC_259 usnic acid 108.925 µM -0.0223451356217129 0.490273379756679 no 1702 0.491086322419458 570 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1073 triclabendazole 3.09 µM -0.0237633161869877 0.489703402869838 no 1703 0.49052070061133 560 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1847 st056231 15 µM -0.0239596039736775 0.489624515038191 no 1704 0.490442415403987 567 5393180 SGTC_456 gingerol 170 µM -0.0249291419537685 0.489234864872247 no 1705 0.490055741267862 564 442793 A herb. SGTC_630 4356-0227 183 µM -0.0268000559686295 0.488482987691469 no 1706 0.489309604289286 558 779312 SGTC_5 0352-0601 109.883 µM -0.0268131500221659 0.488477725634545 no 1707 0.489304382394257 551 762456 SGTC_3100 9120536 49.47 µM -0.0271892775739254 0.488326573562121 no 1708 0.489154383901254 559 16421196 SGTC_922 1866-0035 480 µM -0.0278851527298779 0.488046930917784 no 1709 0.488876875122416 572 3156169 SGTC_682 0kpi-0099 17 µM -0.0281864549314224 0.487925852185983 no 1710 0.488756720166053 565 1714895 YML126C ERG13 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0282415651060248 0.487903706201514 no 1711 0.488734743136259 557 688788 SGTC_2947 9072639 7.68 µM -0.0284482384378954 0.487820655002862 no 1712 0.488652325521276 569 16488146 SGTC_1768 st044301 37.178 µM -0.0291167933838277 0.487552001385768 no 1713 0.488385721146371 560 3931349 SGTC_2695 st077686 51.995 µM -0.0294208590470684 0.487429816819913 no 1714 0.488264468445301 565 2876092 SGTC_1010 4112-3296 15.2 µM -0.0294842352842379 0.487404350106979 no 1715 0.488239195948448 561 704384 SGTC_2395 5646831 180.19 µM -0.0298061293343352 0.487275002999217 no 1716 0.488110835219072 568 6808628 SGTC_2900 5328528 85.29 µM -0.0300276851984332 0.487185975693065 no 1717 0.488022486763317 563 795359 SGTC_1419 3993-2473 62.6 µM -0.0305658561853911 0.486969726295866 no 1718 0.487807886118083 563 704026 SGTC_1346 1488-2224 62.4 µM -0.0319078792614125 0.486430487592138 no 1719 0.487272757549302 562 3722427 SGTC_1784 st039334 36.3 µM -0.0332131024013728 0.485906059271918 no 1720 0.486752324841091 564 3496984 SGTC_776 4476-4378 112 µM -0.0337647333898108 0.485684425584725 no 1721 0.486532379289304 566 2892008 SGTC_1714 st033236 13.627 µM -0.0344621073673365 0.485404241778399 no 1722 0.48625432916413 578 2916566 SGTC_2374 9071832 200 µM -0.0350596366114117 0.485164178297798 no 1723 0.486016093464191 559 17381698 SGTC_3296 9122258 64.045 µM -0.0352148776064295 0.48510180951791 no 1724 0.485954199487466 569 4730474 SGTC_1951 sophoraflavanone G 9.2 µM -0.035681387503606 0.484914389232057 no 1725 0.485768205860675 577 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1633 st005664 67.9 µM -0.037268125565349 0.48427694263044 no 1726 0.485135609971507 572 2063822 SGTC_148 3253-0744 288.01 µM -0.0377106857415172 0.484099158264827 no 1727 0.484959178034246 564 6893655 SGTC_2233 sulbentine 40.3845 µM -0.0377799675938808 0.484071326786566 no 1728 0.484931558256171 567 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_399 oxolinic acid 75 µM -0.0381218018803128 0.483934008364811 no 1729 0.484795284278067 568 4628 A DNA gyrase inhibitor. SGTC_3039 9090270 49.47 µM -0.0385752292757348 0.48375186476242 no 1730 0.484614525881796 560 17173750 SGTC_2184 6075246 200 µM -0.0389122045627845 0.483616502632942 no 1731 0.484480193052687 563 2267320 SGTC_1867 st057372 64 µM -0.0396067184251734 0.483337524126313 no 1732 0.484203335557415 576 688837 SGTC_2532 xanthone 78.9 µM -0.0404505973871322 0.482998558308544 no 1733 0.483866946175156 570 7020 An insecticide. SGTC_3068 9116768 49.47 µM -0.0410303559338198 0.482765690395106 no 1734 0.48363584784823 565 41904888 SGTC_3308 9128332 17.569 µM -0.0412271719085093 0.482686637912061 no 1735 0.483557396016251 558 17332805 YDL196W YDL196W SGTC_1052 3253-3998 198 µM -0.0417014565326345 0.482496141049715 no 1736 0.48336834641387 577 5450317 SGTC_2449 5812982 45.77 µM -0.0417322025588945 0.482483792017002 no 1737 0.483356091192526 561 776185 SGTC_349 k015-0014 24 µM -0.0421578257444108 0.482312843701504 no 1738 0.483186441414815 566 2196908 SGTC_472 calcifediol 10 µM -0.0433025286867185 0.481853098691743 no 1739 0.482730187757193 561 5283731 A vitamin D metabolite. SGTC_10 0279-0212 42.575 µM -0.0446153194328898 0.481325874620073 no 1740 0.48220696583868 578 39851 YBR002C RER2 SGTC_2531 methyl deoxycholate 70.07 µM -0.0451362108295027 0.481116690734631 no 1741 0.48199936937713 573 16667744 Haematoxylin. SGTC_2034 5197015 53.07 µM -0.0453431030565167 0.48103360667838 no 1742 0.481916915739523 575 780676 SGTC_2890 9046729 58.44 µM -0.0454665124478373 0.48098404816259 no 1743 0.481867733238933 576 903329 SGTC_2142 5622915 118.518 µM -0.046197095566069 0.480690667986786 no 1744 0.481576578703781 567 5322196 SGTC_2382 9035899 200 µM -0.0473757195893942 0.480217390192493 no 1745 0.481106890123378 571 6462679 SGTC_569 4130-2812 160 µM -0.0476583386887241 0.480103908297111 no 1746 0.480994268629812 574 743552 SGTC_3060 1327-0027 12.5 µM -0.0480065012881455 0.479964110509323 no 1747 0.480855530652076 561 16000455 YPR107C YTH1 SGTC_2787 5284540 71.43 µM -0.0493926176199556 0.479407567588262 no 1748 0.480303205634424 579 736958 SGTC_912 3474-0017 2.18 µM -0.0494803079456006 0.479372360172307 no 1749 0.4802682649789 567 3360550 SGTC_2871 9038510 12.99 µM -0.0500690066991037 0.479136003480278 no 1750 0.480033698909794 568 4945164 SGTC_1051 3253-3903 78 µM -0.050324363331426 0.47903348260967 no 1751 0.479931954616549 559 5509239 SGTC_956 1185-0240 191 µM -0.0507011427379239 0.478882215321186 no 1752 0.479781833024509 583 1416193 SGTC_1020 4335-0961 93.3 µM -0.0515234756335726 0.478552080303905 no 1753 0.479454197920861 609 669075 SGTC_637 1181-0519 7.26 µM -0.053004018645087 0.477957736499114 no 1754 0.478864352900395 570 6252091 YGR060W ERG25 SGTC_1077 5-fluorocytosine 377 nM -0.0537217904325642 0.477669614363003 no 1755 0.478578410807082 576 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3093 9117344 49.47 µM -0.0538056468784518 0.477635954146371 no 1756 0.47854500524027 571 24824913 SGTC_1162 k048-0130 20.1 µM -0.0546837499990317 0.477283490676225 no 1757 0.478195207806159 595 6797406 SGTC_1231 0242-0792 125 µM -0.0547738670393818 0.477247319427902 no 1758 0.47815931011002 572 3707635 SGTC_1438 4092-1045 4 µM -0.0552486939665939 0.477056736126329 no 1759 0.477970167986112 565 1351342 SGTC_1893 st059353 36.1 µM -0.055301304117254 0.477035620088713 no 1760 0.477949211611377 591 3112488 SGTC_914 3820-6779 408 µM -0.0558740435907286 0.476805744903627 no 1761 0.477721074366134 579 2893481 SGTC_1495 4469-0029 237 µM -0.0561222034374447 0.476706145655974 no 1762 0.477622228013489 579 793680 SGTC_2145 5634607 200 µM -0.0561350549674965 0.476700987718783 no 1763 0.477617109064565 587 308662 SGTC_2845 9003024 42.97 µM -0.0561836827081862 0.476681471102699 no 1764 0.477597739970748 580 2990173 SGTC_2061 5245884 80.95 µM -0.0589828641657428 0.475558122737158 no 1765 0.476482878380871 590 573863 SGTC_1999 st074831 12.5 µM -0.0609802025314247 0.474756682791984 no 1766 0.475687487899935 614 17112523 SGTC_898 1000-0849 28.3 µM -0.0614038022241744 0.47458672475259 no 1767 0.47551881216946 571 6751807 SGTC_2447 5741742 33.78 µM -0.0614320211398216 0.474575402831908 no 1768 0.475507575663848 580 1776504 SGTC_3173 9105693 49.47 µM -0.0622225697280252 0.474258229341186 no 1769 0.475192794634071 591 17096658 SGTC_1545 lovastatin 49.4 µM -0.0632893503935724 0.473830255554875 no 1770 0.474768047958954 578 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3174 9107204 49.47 µM -0.0636619439127295 0.473680784628443 no 1771 0.47461970380385 591 3938802 SGTC_2833 9001315 45.46 µM -0.0650974982997783 0.473104927408089 no 1772 0.47404818613861 566 2989378 SGTC_1871 st057448 67.3 µM -0.0651633970339905 0.473078494178846 no 1773 0.474021952048542 575 691747 SGTC_1547 harmine 94.2 µM -0.0668238849177022 0.472412480505503 no 1774 0.473360954245534 570 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_943 3253-1379 105 µM -0.0676866806836547 0.472066447620664 no 1775 0.473017526134315 575 668464 SGTC_799 1310-0557 151 µM -0.0687051446674897 0.471658009589975 no 1776 0.472612161515443 619 5354492 SGTC_2069 5228469 200 µM -0.0701880356946928 0.471063374230685 no 1777 0.472021998486313 573 2835210 SGTC_2127 5253358 187.912 µM -0.0703241121989704 0.471008811125556 no 1778 0.471967845627462 587 20612 SGTC_2436 5633522 8.09 µM -0.0706689860791549 0.470870528195062 no 1779 0.471830602313396 591 5724242 SGTC_3026 9090633 49.47 µM -0.071088054756344 0.470702500352601 no 1780 0.471663837520972 593 25236842 SGTC_1904 st060225 78 µM -0.0715671301769703 0.470510418874606 no 1781 0.471473199646383 576 66595 SGTC_3018 9082602 49.47 µM -0.0724318192927101 0.470163746051413 no 1782 0.471129131577595 582 17332089 SGTC_3078 9116413 49.47 µM -0.0741193702685811 0.469487235238679 no 1783 0.470457701204084 581 17177322 SGTC_2741 miltefosine 3.04 µM -0.0747071423960991 0.469251627856439 no 1784 0.470223862373311 573 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2273 7815444 169.05 µM -0.074715856796165 0.469248134785907 no 1785 0.470220395519847 584 2824616 SGTC_2401 5128683 200 µM -0.0749366387379094 0.4691596375857 no 1786 0.470132562500318 610 708373 SGTC_449 xestospongin c 11.1929 µM -0.075607236914881 0.468890847511439 no 1787 0.469865789361101 587 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1773 st048542 73.5835 µM -0.0756350205675063 0.468879711535016 no 1788 0.469854736934543 588 3237138 SGTC_3332 9141069 11.198 µM -0.0758749488990428 0.468783546782653 no 1789 0.469759293638187 594 17332883 SGTC_1042 0350-0096 82 µM -0.0759514211827875 0.468752896603018 no 1790 0.469728873390413 581 3122515 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0767540899884861 0.468431197226831 no 1791 0.469409586912032 574 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2344 7990960 76.95 µM -0.0769998806923225 0.468332691573636 no 1792 0.469311819940536 597 140813 SGTC_2134 5324836 1.464 µM -0.0770408403606101 0.468316276336879 no 1793 0.469295527792421 572 699272 SGTC_1770 st043884 66.3 µM -0.0771566689635955 0.468269856478642 no 1794 0.469249455999513 575 670149 SGTC_2930 9013230 14.89 µM -0.0775332425300512 0.468118942581486 no 1795 0.469099673571141 592 2995857 SGTC_420 mitomycin C 81.9 mM -0.0786120369190212 0.467686635321669 no 1796 0.468670606547007 579 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1831 st055328 12 µM -0.0786265342714736 0.467680826029313 no 1797 0.468664840786782 585 1103068 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0790268617874575 0.467520411905406 no 1798 0.468505628629069 593 5393153 SGTC_1494 4358-1428 177 µM -0.0809974112747913 0.466730875884201 no 1799 0.467722005622713 608 1564571 SGTC_1271 0832-2808 169 µM -0.0821918065559665 0.466252383491145 no 1800 0.46724709441137 605 3663794 SGTC_2841 9004761 38.96 µM -0.0823163061966599 0.466202509891265 no 1801 0.46719759397767 582 2991039 SGTC_1488 4013-0813 75.9 µM -0.0825230642569551 0.466119685373224 no 1802 0.467115389129407 587 2910057 SGTC_516 3992-2719 87.3 µM -0.0828448830634895 0.465990771977413 no 1803 0.466987440120415 586 5350887 YDR037W KRS1 SGTC_3200 9114385 49.47 µM -0.083344675642483 0.465790573359186 no 1804 0.466788738907137 600 17018030 YLR208W SEC13 SGTC_3016 9080866 49.47 µM -0.0834061965432592 0.465765930934938 no 1805 0.466764280776499 592 17066299 SGTC_2762 leflunomide 42.06 µM -0.0844119740046226 0.465363081737188 no 1806 0.466364443693169 584 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_416 estradiol valerate 100 µM -0.0875749939572171 0.464096414399664 no 1807 0.465107238865691 592 13791 A steroid. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0879349941593416 0.463952271042378 no 1808 0.464964171503323 570 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2327 6189656 200 µM -0.0884093548335038 0.463762345209877 no 1809 0.46477566316527 600 5349088 SGTC_1931 st074438 57.1 µM -0.0885057004838671 0.463723771080753 no 1810 0.464737376895164 589 2787313 SGTC_2653 dihydrofissinolide 100 µM -0.0887087126259549 0.463642491760375 no 1811 0.464656704081498 580 6857746 SGTC_2968 9090663 33.37 µM -0.089106199049996 0.4634833557928 no 1812 0.464498755432704 634 25236811 SGTC_290 2043-6722 48.1 µM -0.0891449520663778 0.463467841112812 no 1813 0.464483356497299 592 773758 YLR208W SEC13 SGTC_794 k038-0031 316 µM -0.0897628500719493 0.463220474604565 no 1814 0.464237835160487 581 6624242 SGTC_1155 4088-0394 48.2 µM -0.0897678033515449 0.463218491688219 no 1815 0.464235867033226 592 2326248 SGTC_1070 indatraline 8.81 µM -0.0919818737582299 0.462332238554865 no 1816 0.463356220588382 598 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2068 5226020 147 µM -0.0921730907186322 0.462255706503868 no 1817 0.463280258753949 608 1810509 SGTC_251 melphalan 456.522 µM -0.092530874791703 0.462112511931888 no 1818 0.46313813095098 606 460612 A DNA alkylator. SGTC_250 brefeldin a 552.239 µM -0.0927554000166982 0.462022653553311 no 1819 0.463048941911976 576 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_230 MPP+ 141.667 µM -0.0934368918537487 0.461749922139974 no 1820 0.462778241620176 607 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2954 9074818 52.69 µM -0.0946815407010321 0.461251863140493 no 1821 0.462283890243344 606 16648742 SGTC_734 2023-0417 80 µM -0.0953932727884294 0.46096708350771 no 1822 0.462001229624755 591 3935732 SGTC_2620 irigenin 100 µM -0.0954584073997207 0.46094102271735 no 1823 0.46197536271613 580 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1233 0325-0408 14.2 µM -0.0955289853965859 0.460912784181653 no 1824 0.461947334257312 611 12874 SGTC_371 0195-0006 7.36 µM -0.0962289921473331 0.46063271940657 no 1825 0.461669352626514 587 3928593 SGTC_1456 k015-0012 13 µM -0.0990202787701939 0.459516152771549 no 1826 0.460561084550181 612 2989616 SGTC_739 1486-1183 203 µM -0.0997082351057528 0.459241006122188 no 1827 0.460287981228944 602 4346692 SGTC_2986 9022445 71.43 µM -0.101555156556063 0.458502430801426 no 1828 0.459554887614356 587 6459286 SGTC_1337 1486-1011 40.3 µM -0.102299161061937 0.458204947180433 no 1829 0.459259610595637 585 X1337 SGTC_897 1000-0139 31.4 µM -0.102304584731949 0.458202778659696 no 1830 0.459257458157234 617 6151020 SGTC_3022 9087993 49.47 µM -0.103304652101366 0.457802947708551 no 1831 0.458860591766446 574 17173644 SGTC_67 0335-0847 266 µM -0.103749818838721 0.45762498196885 no 1832 0.458683945115124 660 4552207 YOR254C SEC63 SGTC_1567 st069303 68.4 µM -0.104184912653906 0.457451051323333 no 1833 0.458511303384254 598 5581319 SGTC_2222 6885208 172.143 µM -0.104371459745057 0.457376480806099 no 1834 0.458437285392017 587 609514 SGTC_309 k408-0051 1.48 µM -0.106645669434091 0.45646750743528 no 1835 0.457535043094344 601 3640463 SGTC_512 prima-1 270 µM -0.106927352175773 0.456354938096688 no 1836 0.457423306843362 589 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1855 st056195 39.6 µM -0.1080069759799 0.455923518775049 no 1837 0.456995079276294 580 4028379 SGTC_1762 st045503 25.4615 µM -0.108061782745665 0.455901619289314 no 1838 0.456973341764933 607 4645554 SGTC_1716 st033144 30.6155 µM -0.110813318442094 0.454802344375522 no 1839 0.455882191905352 603 674617 SGTC_2109 5483026 200 µM -0.113581647080433 0.453696709672298 no 1840 0.454784718347768 589 759335 SGTC_2182 6325192 200 µM -0.114047177321717 0.453510817912136 no 1841 0.454600197646821 580 736248 SGTC_459 nigericin 15.3 µM -0.115213626992109 0.453045085512848 no 1842 0.454137898913518 639 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3254 9136651 49.47 µM -0.115667754503536 0.452863781879565 no 1843 0.453957931427281 599 16454030 SGTC_2523 spermine 47.74 µM -0.116442572050569 0.452554470239208 no 1844 0.453650898615663 584 1103 A DNA binding polyamine. SGTC_1524 corynanthine 62.1 µM -0.116871303080452 0.45238333069629 no 1845 0.453481019552449 652 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1018 4259-0013 28.1 µM -0.117208805838973 0.452248613597494 no 1846 0.453347294484758 616 6801262 SGTC_2738 aclarubicin 5.55 µM -0.117610424673716 0.452088311185583 no 1847 0.453188172291547 594 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1047 2043-3044 82 µM -0.11865924764955 0.451669720174431 no 1848 0.452772662017543 632 669592 SGTC_2689 tacrolimus 100 µM -0.118804800586648 0.451611633432633 no 1849 0.45271500265317 594 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_175 3793-3120 23.7 µM -0.11892969410262 0.451561792203987 no 1850 0.452665528110047 627 5322297 SGTC_2417 cerulenin 830 nM -0.120229334614826 0.451043190400112 no 1851 0.452150740327284 616 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2601 securinine 100 µM -0.120651100164006 0.450874909179933 no 1852 0.451983696181166 590 442872 A GABA receptor antagonist. SGTC_1027 k015-0025 8.67 µM -0.12069406212849 0.450857768180528 no 1853 0.451966681174357 594 3598955 SGTC_347 4534-1311 26.2 µM -0.121513621483584 0.450530797311162 no 1854 0.451642113133589 594 2862016 SGTC_435 c-PAF 6.7 µM -0.12224424326016 0.450239337217706 no 1855 0.451352794063413 600 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_549 1661-1316 519 µM -0.122623896135372 0.450087896442096 no 1856 0.451202465434194 622 2857282 SGTC_1664 st014217 9.02 µM -0.122713073489672 0.450052325296171 no 1857 0.451167155483284 618 3982782 SGTC_2987 9018338 71.43 µM -0.122955634369634 0.449955574417992 no 1858 0.451071114975804 606 5055682 SGTC_1928 4'-methoxychalcone 40.3 µM -0.123474641259249 0.449748566811883 no 1859 0.450865626977768 591 641818 SGTC_3343 9148379 18.9835 µM -0.124546204839841 0.449321213473265 no 1860 0.450441409485042 604 1955036 SGTC_1602 st001878 87.6 µM -0.126826104422919 0.44841215637745 no 1861 0.449539017113332 610 595405 YLR310C CDC25 SGTC_1873 rapamycin 2 nM -0.126834965662525 0.448408623688862 no 1862 0.449535510309128 607 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_819 1013-0258 27.7 µM -0.12717949684575 0.448271273464395 no 1863 0.449399166371395 626 5753198 SGTC_3132 9126706 49.47 µM -0.127731347132997 0.448051286680225 no 1864 0.449180790927155 604 850858 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.128659190167764 0.44768145210914 no 1865 0.448813664237108 612 616764 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.129084945216994 0.447511763030061 no 1866 0.448645217157385 621 390807 SGTC_624 k048-0052 28 µM -0.12936165832948 0.44740148130547 no 1867 0.448535742464506 600 6835531 SGTC_1843 st055809 45.5 µM -0.129377584868737 0.447395134038522 no 1868 0.448529441642697 602 16413835 SGTC_1226 3909-7979 35.4 µM -0.129505859763716 0.447344012626494 no 1869 0.448478694289415 593 6615510 SGTC_3175 9106517 49.47 µM -0.129926409123258 0.447176417170547 no 1870 0.448312324962611 622 41468073 SGTC_1692 fluoroquinolonic acid 71 µM -0.131779570534228 0.446438016302507 no 1871 0.447579322981894 637 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_422 cantharidin 155 µM -0.132179713586886 0.446278601711775 no 1872 0.447421073266574 594 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2231 micatex 6.853 µM -0.132290330276133 0.446234534217412 no 1873 0.447377327738556 610 20737 An antifungal of unknown mechanism. SGTC_3236 9132701 49.47 µM -0.133410381513962 0.445788365521464 no 1874 0.446934417769965 630 24282524 SGTC_1952 st077036 64.1 µM -0.134073588591411 0.445524211500778 no 1875 0.446672192153448 621 2937007 SGTC_3004 9076122 71.4286 µM -0.135235921270158 0.445061315174058 no 1876 0.446212673445418 631 44782551 SGTC_2536 dehydroabietamide 32.04 µM -0.135325821877222 0.445025515575838 no 1877 0.446177134977843 623 3983547 SGTC_2375 9072683 200 µM -0.135562989007012 0.444931074673408 no 1878 0.446083382888343 607 16798029 SGTC_1673 st016611 27.3 µM -0.135910414732359 0.444792734000547 no 1879 0.445946051055065 621 5226799 SGTC_1444 4112-3581 28 µM -0.136345988225606 0.444619303466566 no 1880 0.445773884981752 594 2877249 SGTC_2837 9008476 45.46 µM -0.136412441050044 0.444592845145845 no 1881 0.445747619539023 650 2992805 SGTC_1028 k015-0029 4.8 µM -0.137358830218784 0.444216065315712 no 1882 0.445373585629882 594 4588309 SGTC_1993 st073995 70.8 µM -0.137861410309581 0.444015996809327 no 1883 0.445174974618366 606 3098394 SGTC_2896 9052656 71.43 µM -0.138550704735162 0.443741623742488 no 1884 0.444902599700152 620 6469436 SGTC_1874 staurosporine 7.6 µM -0.139519065896085 0.443356213976298 no 1885 0.444519995438108 600 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_877 0771-0151 33.1 µM -0.140094023451532 0.443127404994396 no 1886 0.44429285131041 637 6166523 SGTC_2085 5307070 144.047 µM -0.141151567279325 0.442706596498636 no 1887 0.44387510330594 628 2840351 SGTC_203 k066-0004 30.888 µM -0.141348788824782 0.442628126979529 no 1888 0.44379720428755 597 6795412 SGTC_571 k831-0106 44.2 µM -0.141681696893608 0.442495676294576 no 1889 0.443665716423001 620 4783639 SGTC_98 0074-0023 107.663 µM -0.141711181511518 0.442483945864674 no 1890 0.443654071256202 654 3563821 SGTC_142 0335-0849 62.6745 µM -0.142617349423482 0.442123452378318 no 1891 0.443296197346706 601 3889043 YPR107C YTH1 SGTC_2679 rapamycin 1 nM -0.143691092713015 0.441696355789179 no 1892 0.44287220259464 627 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3017 9080681 49.47 µM -0.143988948118419 0.441577891573961 no 1893 0.44275459840754 616 16451914 SGTC_609 0986-0026 86.3 µM -0.144226601371196 0.441483374941813 no 1894 0.442660767845023 620 2848610 SGTC_2 0422-0095 29 µM -0.146383122030917 0.44062586209103 no 1895 0.441809475226565 593 6790840 SGTC_1629 st005085 44.9 µM -0.14717039138315 0.440312883649936 no 1896 0.441498765172548 627 24207091 SGTC_425 3825-7017 13.1 µM -0.148382352644239 0.439831142157688 no 1897 0.441020513224217 595 3397440 SGTC_3072 9116419 49.47 µM -0.150720810178839 0.438901882925889 no 1898 0.440097978308657 619 17170162 SGTC_1540 guanosine 70.6 µM -0.151089584154391 0.438755369654973 no 1899 0.439952524408939 604 6802 Guanosine is a purine nucleoside SGTC_672 1441-0018 53.7 µM -0.151511993968482 0.438587557269433 no 1900 0.439785925120044 611 251141 SGTC_299 1273-0059 1.44 µM -0.152438493073584 0.438219522080279 no 1901 0.439420549370683 624 2848077 SGTC_337 1315-0038 354 µM -0.15348447932687 0.437804086980164 no 1902 0.439008114494864 628 1626437 SGTC_671 0560-0003 407 µM -0.155378886039818 0.437051858923531 no 1903 0.43826131425207 629 3238678 SGTC_224 benfluorex 43.875 µM -0.155586737137576 0.436969339536497 no 1904 0.438179389926697 618 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_480 am 92016 50 µM -0.155998862600528 0.436805728881035 no 1905 0.438016958879567 663 2129 K+ channel blocker. SGTC_2750 bromebric acid 70.15 µM -0.156090813359943 0.436769226606942 no 1906 0.437980719742084 635 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2084 5306078 60.6385 µM -0.156809875571296 0.436483794526762 no 1907 0.437697344781582 640 679340 SGTC_2952 9073731 13.78 µM -0.157271624340347 0.436300520564121 no 1908 0.437515391217376 626 16457353 SGTC_2298 7976326 193.81 µM -0.157314304395722 0.436283580996821 no 1909 0.437498573672955 620 2235818 SGTC_2318 6029776 164 µM -0.157542042001245 0.436193194700062 no 1910 0.437408838414464 638 818325 SGTC_2412 st077135 33.4 µM -0.158316690851807 0.435885770926076 no 1911 0.437103628302642 685 13258915 SGTC_623 k072-0108 16.9 µM -0.158636346829497 0.435758924924026 no 1912 0.436977695379787 637 5382803 SGTC_1895 st058434 18.3 µM -0.159582628800734 0.435383459752417 no 1913 0.436604931903246 669 5393175 SGTC_2870 9038528 12.99 µM -0.160393865637745 0.435061624061927 no 1914 0.436285410787127 643 6463316 SGTC_1980 st071811 45.7 µM -0.160870848110991 0.43487241457747 no 1915 0.436097561528194 662 4974850 SGTC_1745 st081495 74 µM -0.161506648838879 0.434620228238112 no 1916 0.435847187543863 613 13842402 YBL026W LSM2 SGTC_1860 st056228 74.6 µM -0.162756169460246 0.434124691380509 no 1917 0.43535520985857 637 688679 SGTC_1570 verbenone 133 µM -0.163618792397283 0.433782651358974 no 1918 0.435015624943384 634 29025 A natural terpanoid with antifungal properties. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.165600633983009 0.432997016341433 no 1919 0.434235624167849 642 688751 SGTC_440 fluspirilene 35.1 µM -0.165663814567025 0.432971974843685 no 1920 0.434210762144096 642 3396 An atypical antipsychotic. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.168197100328753 0.431968134924465 no 1921 0.433214111025821 614 6708561 SGTC_1166 k206-0078 225 µM -0.16823413446094 0.43195346301854 no 1922 0.433199544105906 616 5404595 SGTC_372 0155-0182 15.9 µM -0.16861721043975 0.431801704348087 no 1923 0.433048871214511 616 771486 SGTC_722 3534-0461 190 µM -0.169023666867205 0.431640694327015 no 1924 0.432889012878426 611 658262 SGTC_2783 7738165 71.43 µM -0.16922252465798 0.431561924712321 no 1925 0.432810806586441 616 17201110 SGTC_292 k038-0015 474 µM -0.174188647196256 0.429595683060328 no 1926 0.430858603685772 636 46368540 SGTC_2248 tofa 1.1 µM -0.174387428069286 0.429517015561526 no 1927 0.430780496943437 635 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2685 mycophenolic acid 18.85 µM -0.175091411085547 0.429238436923287 no 1928 0.430503903491475 621 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_608 k048-0125 159 µM -0.176639775145818 0.428625845819592 no 1929 0.429895674632382 625 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1659 st012954 42.1 µM -0.177077951724572 0.42845251781771 no 1930 0.429723580104384 652 24207262 SGTC_3320 9137005 35.139 µM -0.177290862705478 0.428368302333305 no 1931 0.429639963806135 627 4908713 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.177614778039949 0.42824018609258 no 1932 0.429512758943414 642 6708760 SGTC_2856 9022925 19.48 µM -0.177880597110539 0.428135053959458 no 1933 0.429408374543797 632 4944862 SGTC_3334 9142812 21.919 µM -0.178115044742336 0.428042333545016 no 1934 0.429316313479721 633 45283678 SGTC_2440 5628896 157.78 µM -0.181089075627894 0.426866496841638 no 1935 0.428148829611248 620 5522048 SGTC_58 0957-0393 9 µM -0.181579308660287 0.426672736461546 no 1936 0.427956444092916 635 6997992 SGTC_55 0767-0285 6.563 µM -0.181919723666104 0.42653820077136 no 1937 0.427822862764037 642 3116166 SGTC_107 0358-0022 2.6945 µM -0.182649103195391 0.426249970891688 no 1938 0.427536676791101 669 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2975 9084847 53.72 µM -0.182797430178993 0.426191361134651 no 1939 0.42747848252931 615 27211724 SGTC_470 aa-861 153 µM -0.18378430044675 0.425801451895055 no 1940 0.427091336388436 624 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_93 0109-0045 59.227 µM -0.184233892200523 0.42562384367979 no 1941 0.426914986197031 615 88733 SGTC_172 1112-0046 2.638 µM -0.185164802248585 0.425256141900073 no 1942 0.426549887703865 656 2802135 YIL048W NEO1 SGTC_2383 9036125 200 µM -0.1857010215544 0.425044369189598 no 1943 0.426339613585966 631 79580 SGTC_2874 9043904 71.43 µM -0.186132428646756 0.424874006371243 no 1944 0.426170455936172 633 4463428 SGTC_674 0498-0004 451 µM -0.189492182915602 0.42354772069861 no 1945 0.424853540621527 634 4231473 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.190134740614879 0.423294164865616 no 1946 0.424601773763647 625 5106787 A p450 inhibitor. SGTC_2153 5569715 200 µM -0.190141673791168 0.423291429179607 no 1947 0.424599057375135 638 2054701 SGTC_1961 st076550 68.7 µM -0.190780437847752 0.423039402157241 no 1948 0.424348807757268 636 1579337 SGTC_1164 k060-0068 93.7 µM -0.19183600497868 0.42262299281006 no 1949 0.423935333411605 623 5963676 SGTC_626 0214-0009 33 µM -0.193324068250462 0.422036115548922 no 1950 0.423352589063883 653 3437874 SGTC_2411 st077133 39.94 µM -0.1934767301285 0.421975916999421 no 1951 0.423292814205926 671 1403142 YNL221C POP1 SGTC_2335 9018011 154.17 µM -0.194346344078489 0.421633040407889 no 1952 0.42295235000888 644 6458208 SGTC_62 0180-0423 3.232 µM -0.196137400063616 0.420927039591043 no 1953 0.422251311861101 644 30102 YGL099W LSG1 SGTC_27 0485-0001 32.618 µM -0.196355472917062 0.420841096660801 no 1954 0.422165972624695 632 2054479 SGTC_3159 9100096 49.47 µM -0.196612414354317 0.420739840388323 no 1955 0.422065427494595 614 25236875 SGTC_3127 9126946 49.47 µM -0.19775819812853 0.420288370310579 no 1956 0.421617126624293 666 27243249 SGTC_1742 st038235 28.8875 µM -0.198505503327921 0.419993968124202 no 1957 0.421324789696968 632 564103 YBR002C RER2 SGTC_3283 9109332 35.8195 µM -0.19875799099076 0.419894510277858 no 1958 0.42122602931163 629 17027281 SGTC_1686 st019653 115.5 µM -0.199835936626238 0.419469952492223 no 1959 0.420804447396841 670 97252 SGTC_2261 9010538 184.68 µM -0.20117902073461 0.41894109892948 no 1960 0.420279297577557 704 6457250 SGTC_1345 1488-0192 31.4 µM -0.201200583192352 0.4189326096757 no 1961 0.420270867748165 660 658348 SGTC_2658 polymyxin b sulfate 77.05 µM -0.201493288421269 0.418817373812937 no 1962 0.420156438441068 631 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2282 7944268 200 µM -0.201531534199641 0.418802317249913 no 1963 0.420141487249121 668 2970414 SGTC_289 k017-0060 526 µM -0.202667276389055 0.418355253606788 no 1964 0.419697551004901 638 5512909 SGTC_1769 st044406 64.4 µM -0.204260254182441 0.417728385527659 no 1965 0.419075063856343 651 670903 SGTC_109 0132-0036 33.701 µM -0.207432764076693 0.416480564593666 no 1966 0.417835948488615 620 67274 A color developer. SGTC_2083 5306046 65.942 µM -0.207935780876414 0.416282793483766 no 1967 0.417639555313228 648 539837 SGTC_272 doxorubicin 8.13 µM -0.208602076487884 0.4160208586825 no 1968 0.417379444717462 630 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_809 3998-0021 90 µM -0.210160768145584 0.415408250130479 no 1969 0.416771099113896 643 715485 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.213684148160987 0.414024224928498 no 1970 0.415396686885921 657 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_925 2064-1272 59.6 µM -0.213783610793661 0.413985170241103 no 1971 0.415357903094852 664 6815817 SGTC_1085 doxorubicin 7.67 µM -0.214742997447156 0.413608504197378 no 1972 0.414983848700558 648 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2990 9074105 71.4286 µM -0.215052492406483 0.413487009917677 no 1973 0.414863196413493 652 6502001 SGTC_2457 5731572 11.68 µM -0.215898050783512 0.413155122679916 no 1974 0.414533608260963 670 2865357 SGTC_1778 st046819 58.9 µM -0.216303621818966 0.412995955379892 no 1975 0.414375543044125 623 671715 SGTC_704 1310-0270 142 µM -0.217342936494066 0.412588139249627 no 1976 0.413970549119777 664 5718033 SGTC_281 1672-3440 14.9 µM -0.218904750090058 0.411975477583972 no 1977 0.413362123085401 641 6833000 SGTC_2991 9074669 71.4286 µM -0.220120692220402 0.411498641341816 no 1978 0.41288857997156 664 17333109 SGTC_1358 1509-0022 2.48 µM -0.220355309368035 0.411406650371707 no 1979 0.412797223958714 634 3258434 SGTC_269 exalamide 29 µM -0.220574908214083 0.411320552335692 no 1980 0.412711720101578 630 3316 A derivative of salicylamide. SGTC_273 hydroxyurea 18.1 mM -0.222800020259147 0.410448395065134 no 1981 0.411845576119848 634 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_323 4013-0906 34.3 µM -0.223090478789296 0.410334579205005 no 1982 0.411732544230665 640 2910086 SGTC_1421 4029-0249 71.4 µM -0.223362992494 0.410227801871413 no 1983 0.411626502226489 666 2894095 SGTC_1353 1498-1206 8.11 µM -0.223653255892304 0.410114077106429 no 1984 0.411513560464702 649 6756808 SGTC_1562 morin hydrate 59.1 µM -0.223832989107695 0.410043661690743 no 1985 0.411443629776162 665 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_190 3970-0790 3.722 µM -0.224020186514136 0.409970325057391 no 1986 0.411370797907446 635 2832352 SGTC_477 mead ethanolamide 10 µM -0.224215552993476 0.409893791458495 no 1987 0.411294790999401 626 16061185 SGTC_2168 5727979 200 µM -0.224731320860201 0.409691759116633 no 1988 0.411094148625724 633 695210 SGTC_1668 st014914 51.6 µM -0.225273243266555 0.409479507565561 no 1989 0.410883356750954 624 2839556 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.225808093512619 0.409270051937949 no 1990 0.410675340968761 654 5377381 SGTC_2597 laccaic acid a 100 µM -0.226421921654591 0.409029699266589 no 1991 0.410436639796711 668 5491415 A textile dye. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.227069847072413 0.408776032451864 no 1992 0.410184715106132 680 165506 SGTC_747 3448-8087 38.7 µM -0.22816956044058 0.408345575367879 no 1993 0.409757212277651 681 5168703 SGTC_969 1313-0238 134 µM -0.229656622066607 0.407763675801188 no 1994 0.409179302266441 643 5212874 SGTC_3051 9093778 49.47 µM -0.229714849720644 0.407740894966739 no 1995 0.409156677524238 659 17217378 SGTC_649 1123-0311 367 µM -0.230762547810882 0.407331049691766 no 1996 0.408749639243933 659 693629 YIL048W NEO1 SGTC_3096 9117468 49.47 µM -0.230910664408422 0.407273116661775 no 1997 0.408692102804211 668 41316311 SGTC_1849 st056239 19.2 µM -0.231057624317406 0.407215638053453 no 1998 0.408635017629249 651 5393181 SGTC_3231 9132313 49.47 µM -0.231430769918734 0.407069703217511 no 1999 0.408490081491293 666 4905967 SGTC_3216 9129716 49.47 µM -0.231451431703337 0.407061622903687 no 2000 0.408482056466048 640 8056934 SGTC_1390 3413-2614 145 µM -0.232351485786272 0.406709672412093 no 2001 0.408132513270922 682 3421432 SGTC_1048 3161-0300 24.5 µM -0.232631268333459 0.4066002836502 no 2002 0.408023872362259 634 2165101 SGTC_592 k241-0073 46.5 µM -0.232638623973739 0.406597407856504 no 2003 0.408021016227118 671 4230158 SGTC_485 niflumic acid 177 µM -0.232890377382534 0.406498984266617 no 2004 0.407923265378551 658 4488 A COX2 inhibitor. SGTC_1344 1488-0097 29.1 µM -0.234336266670832 0.405933824998428 no 2005 0.40736196644162 645 747966 SGTC_2795 7780010 54.55 µM -0.235882840186202 0.405329527916194 no 2006 0.406761792059899 646 953673 SGTC_1134 3477-0009 42.5 µM -0.235884625487557 0.405328830470397 no 2007 0.406761099369319 634 3973534 SGTC_1234 0326-0494 15.5 µM -0.236151553260742 0.405224555854792 no 2008 0.406657535625636 686 1547813 SGTC_1735 st034310 56.75 µM -0.240858890257344 0.403386759239957 no 2009 0.40483224251948 649 871153 SGTC_2224 6650123 117.647 µM -0.243793536313371 0.402242116811358 no 2010 0.403695363297432 654 2908370 SGTC_3300 9124615 50.48 µM -0.246026858728946 0.401371582596833 no 2011 0.402830720563581 668 24824903 SGTC_210 3551-0445 56.827 µM -0.246281612355795 0.401272312340081 no 2012 0.402732121435427 684 2865180 YOR207C RET1 SGTC_3069 9117009 49.47 µM -0.247034238038288 0.400979072722898 no 2013 0.402440863461965 640 41904981 SGTC_650 1328-0195 38 µM -0.248477974144414 0.400416717453038 no 2014 0.401882304942913 672 2780821 SGTC_1943 st076331 65.2 µM -0.248916052994433 0.400246120413157 no 2015 0.401712858776505 657 24208415 SGTC_1511 0906-3109 28.5 µM -0.24953444897247 0.400005336524661 no 2016 0.401473698525768 650 2882180 SGTC_2269 7935389 174.42 µM -0.249794077257566 0.39990425678377 no 2017 0.401373300125116 635 97605 SGTC_2147 5545932 89.7195 µM -0.250193982716172 0.399748576777488 no 2018 0.401218669204719 692 797404 SGTC_2460 5552655 174.22 µM -0.250317488265755 0.399700500271327 no 2019 0.401170916601144 649 5401989 SGTC_2235 salicylic acid 500 µM -0.250398506167078 0.399668963586158 no 2020 0.40113959236745 648 338 A COX inhibitor and kinase inhibitor. SGTC_2006 4011487 200 µM -0.251568656541515 0.399213548900039 no 2021 0.400687244012868 653 45595294 SGTC_1208 2323-2347 50.3 µM -0.253988045493389 0.398272374466468 no 2022 0.399752396826253 682 5412760 SGTC_1963 st076565 50.3 µM -0.254152749397495 0.39820832390353 no 2023 0.399688776378542 648 4914280 SGTC_2778 tioconazole 65.09 nM -0.254465254045153 0.398086803670972 no 2024 0.399568072016091 675 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2071 5230951 39.92 µM -0.255350818756691 0.397742497629003 no 2025 0.399226076400736 638 1799272 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.255436560449405 0.397709165630102 no 2026 0.399192967978391 708 65057 A dermal irritant. YDR527W RBA50 SGTC_1329 1447-1697 50.6 µM -0.256375289677369 0.397344284456766 no 2027 0.398830533181764 656 2840515 SGTC_3177 9107506 49.47 µM -0.256561276654349 0.397272002539304 no 2028 0.398758735647744 664 8897194 SGTC_1909 st060837 51.5 µM -0.257737644725755 0.396814901062425 no 2029 0.398304695531568 694 678937 SGTC_2792 7535235 81.82 µM -0.258711228846754 0.396436702535042 no 2030 0.397929027547566 650 1281891 SGTC_614 0462-0418 107 µM -0.261982809297125 0.395166539933126 no 2031 0.396667347817575 651 5188303 SGTC_2180 6301957 200 µM -0.262247567084381 0.395063798533855 no 2032 0.396565291512063 687 845462 SGTC_847 0342-0274 5.54 µM -0.262451717193586 0.394984581415052 no 2033 0.396486602513941 675 18097 SGTC_666 0272-0154 136 µM -0.264004989483388 0.394382001825543 no 2034 0.395888037031764 653 6870312 SGTC_2821 7996764 71.43 µM -0.265019863044246 0.393988426108169 no 2035 0.395497080130019 631 2987135 SGTC_402 epigallocatechin gallate 10 µM -0.265646857865934 0.393745326795926 no 2036 0.395255597187983 673 65064 An antioxidant. SGTC_1314 1222-0010 41.1 µM -0.266563298720948 0.393390077571637 no 2037 0.394902708382177 666 3526027 SGTC_3245 9134821 49.47 µM -0.266882747873724 0.393266267112168 no 2038 0.394779720111291 675 17014901 SGTC_3321 9137793 26.8275 µM -0.267201791548423 0.393142624578875 no 2039 0.39465689841492 652 4904192 SGTC_1990 st072050 59.8 µM -0.267582779331823 0.39299499027937 no 2040 0.394510243918761 656 17233948 SGTC_2022 5136654 200 µM -0.268063431291735 0.392808757668 no 2041 0.394325246794185 697 1713771 SGTC_1842 st055362 61.2 µM -0.268520936713338 0.392631516166676 no 2042 0.39414918063201 646 676032 SGTC_545 4218-0007 221 µM -0.269087766786333 0.392411952246794 no 2043 0.393931072026634 689 2840508 SGTC_69 0096-0274 206.684 µM -0.269329772495845 0.392318220783698 no 2044 0.393837961606455 683 6741392 SGTC_1757 st041620 31.8375 µM -0.269475757002014 0.39226168240518 no 2045 0.393781797771979 674 5289815 SGTC_1936 st074407 74.3 µM -0.269832470628784 0.392123540259382 no 2046 0.393644570552915 649 809813 SGTC_2259 7964009 200 µM -0.269905833520525 0.392095131178662 no 2047 0.393616349590986 663 313134 SGTC_1515 3460-0031 42.1 µM -0.270002993738628 0.392057507695433 no 2048 0.393578975222958 661 2876596 SGTC_2250 alverine citrate 130 µM -0.270150973368977 0.392000207281341 no 2049 0.393522054167895 654 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1825 st052143 62.6 µM -0.270940384888172 0.391694572334684 no 2050 0.393218441820103 690 674173 SGTC_3207 9114163 49.47 µM -0.271465277493545 0.3914913876518 no 2051 0.393016600943212 730 849233 SGTC_3030 9087619 49.47 µM -0.272832281889676 0.390962362553512 no 2052 0.392491071631132 656 25236973 SGTC_2066 5222451 176 µM -0.273980529811796 0.390518151140473 no 2053 0.392049792159088 682 2281147 SGTC_1188 1403-0014 4.57 µM -0.275399406484023 0.389969441626935 no 2054 0.391504700009833 673 9614867 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.275433965548952 0.389956079638069 no 2055 0.391491426050402 665 6857784 SGTC_2519 cryptotanshinone 88.04 µM -0.275715005721719 0.389847422509962 no 2056 0.391383484655733 663 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_837 0091-0265 12.5 µM -0.275806664029904 0.38981198698694 no 2057 0.391348282508952 664 759367 SGTC_1318 1280-3875 124 µM -0.276124246331441 0.389689215296002 no 2058 0.39122631923102 692 373245 SGTC_265 mycophenolic acid 32.932 µM -0.278276337092918 0.388857545728916 no 2059 0.390400119636998 687 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3240 9133527 49.47 µM -0.278861909717263 0.388631340738933 no 2060 0.39017540051204 707 17617455 SGTC_2743 auranofin 4.32 µM -0.279488400594634 0.38838937095778 no 2061 0.389935019243663 653 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.279875104779374 0.388240035681956 no 2062 0.389786663874312 657 66535 A nucleotide analog. SGTC_2236 dapsone 200 µM -0.280340653704422 0.388060274501504 no 2063 0.38960808177425 663 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_150 3970-0969 77.2 µM -0.28075522978468 0.387900215517132 no 2064 0.389449072203917 678 6615640 SGTC_2136 5328288 199.296 µM -0.283844911153722 0.386707956974467 no 2065 0.388264617616769 668 262395 SGTC_3027 9089541 49.47 µM -0.285041602159434 0.386246459525629 no 2066 0.387806134732818 677 9943819 SGTC_2826 7992541 19.48 µM -0.287182410567776 0.385421270015188 no 2067 0.386986326829176 709 2985066 SGTC_2486 5283202 22.39 µM -0.289556486343346 0.384506772304821 no 2068 0.386077780142118 679 1377751 SGTC_3 0833-0587 95.581 µM -0.289871199105316 0.38438559256673 no 2069 0.385957387940069 673 5382644 SGTC_2552 juarezic acid 87.02 µM -0.290308267996699 0.384217318503656 no 2070 0.385790207073182 665 1549512 SGTC_3186 9110464 49.47 µM -0.290631604556444 0.384092846089664 no 2071 0.385666542996279 678 17018021 SGTC_3114 9122766 49.47 µM -0.291090882137359 0.383916062047724 no 2072 0.385490906568701 665 17176985 SGTC_2234 tolnaftate 200 µM -0.291159331264861 0.383889716838456 no 2073 0.385464732338205 682 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2340 7987427 183.45 µM -0.29209317382076 0.383530346217204 no 2074 0.385107692862353 683 2239331 SGTC_1785 bathophenanthroline 24 µM -0.292107226631295 0.383524939038559 no 2075 0.385102320742349 673 72812 An iron chelator. SGTC_3294 9122953 26.2835 µM -0.293635960355286 0.382936855268488 no 2076 0.384518047044954 668 16459826 SGTC_1852 st056254 31.4 µM -0.293797586526576 0.382874695548272 no 2077 0.384456289708444 675 442583 SGTC_892 0929-0076 29 µM -0.296300796648511 0.381912373399865 no 2078 0.383500188808215 654 5751038 SGTC_2289 7946404 165.07 µM -0.296427218243375 0.38186379178009 no 2079 0.38345192084919 667 1246120 YPR165W RHO1 SGTC_3354 9151612 71.43 µM -0.297906662308725 0.381295405627009 no 2080 0.382887201459066 698 27261949 SGTC_2368 9071271 200 µM -0.299012392055956 0.380870763466201 no 2081 0.382465295190728 702 27209959 SGTC_2157 5649910 96.377 µM -0.299733980198088 0.380593723569344 no 2082 0.382190038569503 694 2858091 SGTC_1625 st003711 30.1 µM -0.301532555373253 0.379903461959613 no 2083 0.381504214439626 672 24207034 YER133W GLC7 SGTC_2204 7233102 200 µM -0.301773014787812 0.379811206788347 no 2084 0.381412551735155 686 2172480 SGTC_2666 tannic acid 100 µM -0.301898426051504 0.379763093949418 no 2085 0.381364747821518 678 16134267 A thiamine antagonist. SGTC_1363 1636-0063 10.4 µM -0.302984201140415 0.379346624548075 no 2086 0.380950950858233 678 6072185 SGTC_1096 rimcazole 32.2 µM -0.304434970178478 0.378790373399544 no 2087 0.380398264488734 691 18528119 A dopamine reuptake inhibitor. SGTC_2910 7948405 25.97 µM -0.305050113725581 0.378554591914347 no 2088 0.380163992427569 673 2971328 SGTC_2654 protoveratrine a 100 µM -0.305483095075733 0.378388659400067 no 2089 0.379999121606335 692 5702278 A heart drug and vasodilator. SGTC_1385 3091-4834 14.1 µM -0.309160956875616 0.376980090354117 no 2090 0.378599545942711 676 4072814 SGTC_183 3914-0051 30.55 µM -0.310996072788322 0.376277877377975 no 2091 0.377901803582298 673 1596232 SGTC_896 0964-0007 44.5 µM -0.311895715320546 0.375933775661507 no 2092 0.377559889439229 675 6756758 SGTC_3095 9117207 49.47 µM -0.312014191008273 0.37588846757591 no 2093 0.377514869238572 689 17015229 SGTC_3077 9117319 49.47 µM -0.312420870424339 0.375732956149243 no 2094 0.377360345649172 691 17154678 SGTC_2290 7904846 200 µM -0.312921822331365 0.37554142331334 no 2095 0.377170028882974 678 2962154 SGTC_737 1950-0117 57.9 µM -0.31362396252971 0.37527302022301 no 2096 0.376903328839944 688 5393513 SGTC_812 4251-0442 148 µM -0.313681423613438 0.375251057576264 no 2097 0.376881505492624 700 5723007 SGTC_443 clozapine 122 µM -0.316301833903686 0.374249920987322 no 2098 0.375886709652989 701 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2253 7938677 135.83 µM -0.316360636601684 0.374227464914576 no 2099 0.375864395603999 683 2301972 SGTC_1016 4226-1401 38 µM -0.316624387458876 0.374126746752101 no 2100 0.375764314325195 687 2901613 SGTC_1591 genipin 88.4 µM -0.317264596641924 0.373882306736892 no 2101 0.37552141926054 682 442424 A DNA cross-linking agent. SGTC_748 act1.228 77.9 µM -0.319361355891302 0.373082092864924 no 2102 0.374726255609456 689 4421505 YNR035C ARC35 SGTC_2497 7-hydroxyflavone 100 µM -0.320139381071942 0.372785303868092 no 2103 0.374431336773953 686 5281894 SGTC_464 bw-b 70c 158 µM -0.321389340130625 0.37230864699322 no 2104 0.373957680168733 718 5353454 SGTC_749 1000-0129 128 µM -0.322400675001069 0.371923129666201 no 2105 0.37357458646299 724 708470 SGTC_1343 1487-0095 224 µM -0.322737326389771 0.371794827790117 no 2106 0.37344709058654 717 4560101 YGL055W OLE1 SGTC_2846 9008642 19.48 µM -0.323145914677273 0.371639129027347 no 2107 0.373292369534325 753 2992898 SGTC_941 3237-0776 460 µM -0.323267902973308 0.371592647606209 no 2108 0.373246179908701 693 760008 SGTC_2208 7283366 200 µM -0.323391922336905 0.371545394202871 no 2109 0.373199223107228 685 898663 SGTC_2488 5268135 45.7 µM -0.323564199568227 0.37147975697577 no 2110 0.373133997807456 714 1270356 YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.32373867561912 0.371413285812219 no 2111 0.37306794372569 719 5013332 SGTC_1190 1486-1332 13 µM -0.324668017288398 0.371059293725495 no 2112 0.372716171463904 706 4150046 SGTC_1091 telmisartan 47.6 µM -0.324693447063957 0.371049608895908 no 2113 0.372706547334434 705 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2926 9010726 65.15 µM -0.326533372511643 0.370349097647415 no 2114 0.372010422066643 724 2994293 SGTC_1817 st052116 64.4 µM -0.326548253172795 0.370343433910954 no 2115 0.372004793755198 686 4361398 SGTC_3298 9116858 71.43 µM -0.326731485231439 0.370273696162647 no 2116 0.371935492148334 728 2506942 SGTC_342 k048-0088 23.3 µM -0.327291341046263 0.370060642606154 no 2117 0.371723770485684 663 6820570 SGTC_2214 7179297 48.276 µM -0.327858686088511 0.369844779689187 no 2118 0.371509256182248 668 769744 SGTC_1325 1431-0015 227 µM -0.328721230569885 0.369516678139584 no 2119 0.371183202834639 684 1103340 SGTC_1045 1348-1485 165 µM -0.329003358530678 0.369409380662161 no 2120 0.371076574744246 694 6810614 SGTC_627 1391-0720 175 µM -0.330009574040952 0.369026784752363 no 2121 0.370696363985912 701 997839 SGTC_359 0081-0058 15.9 µM -0.330097197023707 0.368993473775501 no 2122 0.370663260547 741 3494159 SGTC_868 0527-0199 213 µM -0.330190966590348 0.368957827187528 no 2123 0.370627836026034 703 2849450 SGTC_995 3931-2021 34.6 µM -0.331549414228248 0.368441538638988 no 2124 0.370114761176044 697 730143 SGTC_3179 9107801 49.47 µM -0.331706082218588 0.368382011008501 no 2125 0.370055603767117 675 4818259 SGTC_978 1416-0512 87.4 µM -0.332771575723819 0.367977249551082 no 2126 0.369653357920283 720 6814003 SGTC_1247 0448-0043 5.84 µM -0.333686182647306 0.367629924000412 no 2127 0.369308188602091 718 3089013 YGL099W LSG1 SGTC_1597 7-benzyloxygramine 47.5 µM -0.335134668346779 0.36708007743805 no 2128 0.368761750976201 700 260807 SGTC_1672 st016598 6.51 µM -0.335641624536833 0.366887700704055 no 2129 0.368570565613531 715 4665860 YNL267W PIK1 SGTC_2730 imipramine 71.33 µM -0.335646950133651 0.366885679955426 no 2130 0.368568557375559 695 3696 A tricyclic antidepressant. SGTC_2958 9077254 16.72 µM -0.336039980691424 0.366736558316985 no 2131 0.368420358754467 692 16457351 SGTC_383 2324-0395 7.37 µM -0.336126704435322 0.366703656746422 no 2132 0.368387660778827 716 3146421 SGTC_2806 7952793 58.44 µM -0.336604670256313 0.366522341907154 no 2133 0.368207467554021 683 2972490 SGTC_2476 5806916 10.51 µM -0.337015264896072 0.366366607896976 no 2134 0.368052696425843 686 2870194 SGTC_2656 pseudo-anisatin 100 µM -0.337653306878129 0.366124649294895 no 2135 0.367812232922369 678 6708809 A neurotoxin. SGTC_1565 sinapyl alcohol 95.1 µM -0.33928664635774 0.365505496193692 no 2136 0.367196900673318 704 5280507 A phenol propionate derived from cinnamic acid. SGTC_2895 9054447 58.44 µM -0.339589203260423 0.365390843779033 no 2137 0.367082955000698 688 2697450 SGTC_648 0375-0473 33.3 µM -0.342094034676808 0.364442113383175 no 2138 0.366140063287748 708 1713139 SGTC_2059 5238311 157 µM -0.343485122081662 0.363915582874069 no 2139 0.365616765820162 675 703021 SGTC_138 0850-0259 40.9225 µM -0.34525655462898 0.363245462513542 no 2140 0.364950752572727 701 6813004 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.345925158140394 0.362992643191007 no 2141 0.364699480537921 682 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1366 1683-0113 21.9 µM -0.346648024501723 0.362719372595464 no 2142 0.364427881022385 693 708623 SGTC_2875 9039966 71.43 µM -0.347465575164257 0.362410392027736 no 2143 0.364120788184774 707 6463691 SGTC_1709 st033179 39.1045 µM -0.348155890679899 0.362149567767301 no 2144 0.363861556017609 692 573381 SGTC_2753 fluvastatin 17.09 µM -0.348414582830411 0.362051841709376 no 2145 0.363764426151595 701 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2949 9072542 2.23 µM -0.349415933073299 0.361673646745482 no 2146 0.363388536690921 729 16457352 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.35442146247642 0.359785165284105 no 2147 0.361511526195434 683 3256 An antibiotic and ribosome inhibitor. SGTC_2557 derrustone 83.84 µM -0.354500704911569 0.359755296137902 no 2148 0.361481837923326 744 629853 An antioxidant. SGTC_2621 lithochol-11-enic acid 100 µM -0.354533377256741 0.359742981078535 no 2149 0.361469597433348 733 6708711 SGTC_744 1594-0068 283 µM -0.354564802927202 0.359731136060792 no 2150 0.361457824136034 686 668392 SGTC_944 3370-0224 231 µM -0.354592754586721 0.359720600586442 no 2151 0.361447352450656 691 4580514 SGTC_1094 duloxetine 25.4 µM -0.355134931363349 0.359516265675876 no 2152 0.361244254295125 686 60834 A selective serotonin reuptake inhibitor. SGTC_2446 5162541 200 µM -0.35517409797984 0.359501506164804 no 2153 0.361229584085727 681 1549321 SGTC_2067 5224629 34.075 µM -0.357358127690946 0.358678810745231 no 2154 0.360411859602371 703 2835000 SGTC_3228 9131799 49.47 µM -0.357560969843174 0.358602435958975 no 2155 0.360335945618957 700 17015818 SGTC_2232 chlorophetanol 41.5365 µM -0.357758046559672 0.358528237408933 no 2156 0.360262194631804 704 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3032 9089427 49.47 µM -0.358426045274158 0.358276778460331 no 2157 0.360012251669006 706 17173707 SGTC_1371 2421-0008 32.7 µM -0.359652140516035 0.357815391714764 no 2158 0.359553643274151 714 2827552 SGTC_2622 2-methoxyxanthone 59.94 µM -0.362092501095378 0.356897688402096 no 2159 0.358641453621615 692 71034 A hepatoprotective. SGTC_685 1278-0033 54.9 µM -0.362193464089299 0.356859738821759 no 2160 0.358603731686846 683 3590572 SGTC_705 1124-0212 310 µM -0.36373896608313 0.356278998504058 no 2161 0.358026471442207 727 9554485 SGTC_220 paclitaxel 373.376 µM -0.365766030857686 0.355517810587474 no 2162 0.357269834734556 714 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2854 9024559 71.43 µM -0.367559340345451 0.354844880642389 no 2163 0.356600918624711 731 3163529 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.371199748865801 0.353480230377036 no 2164 0.355244380073709 716 165521 SGTC_1238 0333-0287 48.8 µM -0.372192029160579 0.353108587887565 no 2165 0.354874940150748 704 7226 SGTC_2086 5274770 176.623 µM -0.372542835716409 0.352977232475995 no 2166 0.354744362554338 707 689278 SGTC_562 3772-2733 112 µM -0.373593010438003 0.352584111615498 no 2167 0.354353567439198 718 2876874 YIL048W NEO1 SGTC_1124 fisetin 1.16336 µM -0.374145052800193 0.352377523974753 no 2168 0.354148200728059 725 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_354 2783-3500 4.88 µM -0.374606211234496 0.352204980682018 no 2169 0.353976676494275 713 6740761 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.375361033271612 0.351922628256752 no 2170 0.353695990356701 748 6710655 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.375920270887742 0.351713489734243 no 2171 0.353488084999588 715 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1308 1187-1617 41.4 µM -0.376310902198628 0.351567431653263 no 2172 0.353342887603298 714 2882570 SGTC_2001 4023502 57.655 µM -0.376638807575221 0.351444843879479 no 2173 0.353221021870781 685 108941 YCR052W RSC6 SGTC_1995 st072814 61.1 µM -0.376993981804902 0.351312079046947 no 2174 0.35308903867345 696 5769371 SGTC_2016 5121758 140 µM -0.377578770547217 0.351093523384062 no 2175 0.352871768936831 736 2795203 SGTC_580 1123-0028 41 µM -0.37953116931571 0.350364201839515 no 2176 0.352146731397904 720 1677248 YPR107C YTH1 SGTC_2556 citropten 84.59 µM -0.379572693826425 0.350348696273882 no 2177 0.352131316791851 682 2775 A potential DNA crosslinker. SGTC_2266 7929956 200 µM -0.3799350229998 0.350213410411568 no 2178 0.351996824339249 718 2967153 SGTC_2818 7996756 12.99 µM -0.380337620464023 0.350063111532358 no 2179 0.351847406471218 697 2241621 SGTC_2718 lomofungin 53.02 µM -0.380747249133965 0.349910211845673 no 2180 0.351695402559618 724 5351222 A RNA synthesis inhibitor. SGTC_1169 aniline yellow 25.8 µM -0.380854524570415 0.349870173793723 no 2181 0.351655598993546 716 6051 A DNA damaging agent. SGTC_17 0960-0276 49.807 µM -0.381241367642777 0.349725807515363 no 2182 0.351512077930409 715 6821114 SGTC_1227 3909-8010 46.6 µM -0.381468493120655 0.3496410564963 no 2183 0.351427822897585 705 15982272 SGTC_1056 3448-1962 115 µM -0.381862634873825 0.349494001767441 no 2184 0.351281628418462 703 715507 SGTC_3061 glucosamine 200 µM -0.383130007542416 0.349021296773969 no 2185 0.350811685628643 709 91431 and experimental redox chemotherapeutic SGTC_200 k038-0079 37.545 µM -0.383653210464066 0.348826220662036 no 2186 0.350617748063431 710 3436683 SGTC_54 0159-0055 9 µM -0.384646881471482 0.348455840648045 no 2187 0.350249527551382 764 3319099 SGTC_694 1315-0438 43.2 µM -0.386663630237022 0.347704563945865 no 2188 0.349502622324037 737 6793154 SGTC_164 4100-3994 89.624 µM -0.386863476054933 0.347630150132893 no 2189 0.349428640858127 737 4615967 SGTC_827 3253-0474 693 µM -0.387065922343852 0.34755477400411 no 2190 0.349353702548438 735 5402065 SGTC_135 0933-0004 26.348 µM -0.38741492389093 0.347424845613279 no 2191 0.349224528559779 720 21230617 YGL099W LSG1 SGTC_329 k048-0121 21.3 µM -0.388020930205438 0.347199280537424 no 2192 0.349000272333756 711 6832902 SGTC_368 fentichlor 4.58 µM -0.389038064401668 0.346820808876994 no 2193 0.348623994351241 757 7329 A pesticide. SGTC_1065 prochlorperazine maleate 2.48 µM -0.391630001588653 0.345857050701082 no 2194 0.347665808532326 735 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1255 0566-0045 221 µM -0.391760518579669 0.345808546998254 no 2195 0.347617584750635 708 2788469 SGTC_154 3389-1638 511.116 µM -0.393323105434455 0.345228043457519 no 2196 0.347040427471159 764 5238686 SGTC_3050 9093513 49.47 µM -0.39513102977421 0.344556850836562 no 2197 0.346373094883409 729 25236664 SGTC_451 chloral hydrate 100 µM -0.395375844012237 0.344466001007644 no 2198 0.34628276678893 744 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3243 9134147 49.47 µM -0.39538544395459 0.344462438680626 no 2199 0.346279224916107 731 24282180 SGTC_1474 0330-0125 5.35 µM -0.395617466640648 0.344376344372633 no 2200 0.346193624861939 720 X1474 SGTC_1761 st044296 37 µM -0.396693106415024 0.343977323011876 no 2201 0.345796892134584 715 1826700 SGTC_2432 5630864 12.22 µM -0.398207319514849 0.343415902092174 no 2202 0.345238685488444 746 5714970 SGTC_2507 purpurin 79.67 µM -0.398484189073524 0.343313285180024 no 2203 0.345136655346173 696 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_63 0099-0242 26.702 µM -0.399247341270809 0.343030495836596 no 2204 0.344855481828137 734 3898502 YLR359W ADE13 SGTC_232 clozapine 119 µM -0.400087791704782 0.34271916500261 no 2205 0.344545927893953 705 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2399 5884133 200 µM -0.403841559907665 0.341329950476099 no 2206 0.343164616458015 732 722445 SGTC_3338 9144300 39.5675 µM -0.404202931126252 0.341196325313949 no 2207 0.343031749247655 720 4901274 SGTC_2705 st078069 42.8 µM -0.405194950459026 0.340829606179384 no 2208 0.342667108209724 735 1530061 SGTC_3131 9127911 49.47 µM -0.405950976763479 0.340550227372242 no 2209 0.342389310578794 738 45595681 SGTC_2388 9080168 200 µM -0.406430928519722 0.34037291337952 no 2210 0.342212999221994 722 15943073 SGTC_577 r071-0003 38.6 µM -0.409516490268314 0.339233823520504 no 2211 0.341080333847865 709 4568517 YMR134W ERG29 SGTC_528 3492-0019 172 µM -0.410461248683054 0.338885342202494 no 2212 0.340733812215294 716 2869262 SGTC_2873 9040596 71.43 µM -0.411856924961001 0.338370788687089 no 2213 0.34022214734227 785 6463863 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.412916504516581 0.337980347629956 no 2214 0.339833894225604 713 688662 SGTC_3013 9080133 71.4286 µM -0.412958268003091 0.337964961903751 no 2215 0.339818594647494 722 17050193 SGTC_3289 9119912 71.43 µM -0.413518946456134 0.337758433405204 no 2216 0.339613222033929 767 17014829 SGTC_1469 k284-2957 126 µM -0.414613819974223 0.337355272545498 no 2217 0.339212314798463 721 23884841 SGTC_2264 7948757 110.76 µM -0.414982963286973 0.33721938644558 no 2218 0.339077187463029 718 2971411 SGTC_1270 0831-1170 17.3 µM -0.416810494877894 0.336546963116179 no 2219 0.338408512702031 742 6764716 SGTC_2463 5473429 200 µM -0.417890006226521 0.336150012161863 no 2220 0.33801376983885 726 5399405 SGTC_1210 3013-0140 750 nM -0.417942340967063 0.336130772606663 no 2221 0.337994637215472 737 905973 SGTC_2709 st078560 56 µM -0.421714527596791 0.334745156034381 no 2222 0.336616699651371 747 17250903 SGTC_2024 5144227 134 µM -0.421969180139439 0.334651696680672 no 2223 0.336523756667555 723 3475211 SGTC_108 0509-0257 621.132 µM -0.422126671131704 0.334593901455725 no 2224 0.336466280665516 714 536624 SGTC_3311 9131146 2.8755 µM -0.422670576465969 0.334394332052277 no 2225 0.336267812964463 724 4900406 YPR165W RHO1 SGTC_1057 3448-5381 134 µM -0.422990997479407 0.334276785274708 no 2226 0.336150914664684 726 5497911 SGTC_3133 9127736 49.47 µM -0.423601594311757 0.334052832194278 no 2227 0.335928196203149 728 27243420 SGTC_3249 9135183 49.47 µM -0.424239915436864 0.333818773632995 no 2228 0.335695426739521 737 4902779 SGTC_79 0052-0007 94.094 µM -0.425331892305936 0.333418519235684 no 2229 0.335297373856678 733 2801472 SGTC_575 k072-0246 11.9 µM -0.425928257240876 0.333200006989361 no 2230 0.335080061932285 741 6796779 SGTC_1243 0416-0003 5.65 µM -0.426316451095492 0.333057800481255 no 2231 0.334938635994603 738 2141977 SGTC_2652 actinonin 100 µM -0.426475575931032 0.332999515439193 no 2232 0.334880670743672 734 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2174 5790901 200 µM -0.426490039976046 0.33299421767631 no 2233 0.334875402044004 730 786020 SGTC_2943 9068529 45.32 µM -0.430127159309555 0.331663106144063 no 2234 0.333551572289688 730 3270634 SGTC_1232 0279-0259 161 µM -0.430409508925916 0.331559860522954 no 2235 0.333448889746705 724 1560000 SGTC_1225 1216-0074 20.6 µM -0.43090749155695 0.331377796456699 no 2236 0.333267818010488 729 4241466 SGTC_1496 4469-0713 57.4 µM -0.43129830642839 0.331234941172708 no 2237 0.333125740809309 758 746691 SGTC_1003 4049-0218 100 µM -0.431868693458456 0.331026490624033 no 2238 0.332918424761981 732 295161 SGTC_1466 k213-0079 57.5 µM -0.432358970691458 0.330847358413714 no 2239 0.332740266674249 753 3657981 SGTC_735 3076-0345 636 µM -0.433675641819695 0.330366479046966 no 2240 0.332261998613379 710 2888990 SGTC_3201 9113999 49.47 µM -0.434628751279131 0.330018555623856 no 2241 0.331915961121921 753 16649224 SGTC_2025 5147754 141 µM -0.434856745455269 0.329935350319393 no 2242 0.331833206412689 726 315777 YLR208W SEC13 SGTC_2434 5670830 169.91 µM -0.435410124148162 0.329733432603122 no 2243 0.331632381495874 753 1549830 SGTC_311 1315-0136 58 µM -0.437432760622424 0.328995832167946 no 2244 0.330898764846757 743 6759207 SGTC_839 0122-0028 230 µM -0.43743568056596 0.328994767824361 no 2245 0.330897706242399 754 759448 SGTC_1176 0848-0131 83.3 µM -0.437548608034823 0.328953605891127 no 2246 0.330856766244768 747 6769040 SGTC_767 0929-0023 86 µM -0.438392883050867 0.328645934364251 no 2247 0.330550752338657 721 1204563 SGTC_2779 methotrexate 400 µM -0.438564355219717 0.328583460489296 no 2248 0.330488614775442 726 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_660 4031-1742 102 µM -0.438828253402826 0.32848732164083 no 2249 0.330392993284115 722 6738706 SGTC_768 0384-0033 77.3 µM -0.438995070133622 0.328426555694301 no 2250 0.330332554227307 748 3965305 YMR134W ERG29 SGTC_902 1120-0002 2.07 µM -0.442018302198073 0.327326077655567 no 2251 0.32923798096917 740 3280475 SGTC_3090 9117696 49.47 µM -0.443305871201225 0.326857847942393 no 2252 0.328772254830769 745 7923821 SGTC_3153 9100258 49.47 µM -0.444502326541248 0.326422996302464 no 2253 0.328339723581873 759 25236848 SGTC_825 1988-2224 89.6 µM -0.4450843636389 0.326211540161875 no 2254 0.328129394137767 733 1180859 SGTC_1078 idebenone 36.1 µM -0.445362459356048 0.326110526717873 no 2255 0.32802891854079 741 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_570 0987-0065 62.6 µM -0.446356405900766 0.325749597208391 no 2256 0.327669908791742 705 3104428 SGTC_2612 dictamnine 15.46 µM -0.446914029175933 0.325547180226973 no 2257 0.327468567074986 726 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_891 0929-0073 133 µM -0.44699083868089 0.325519302442743 no 2258 0.327440837303402 756 5603632 SGTC_1707 st032323 6.317 µM -0.44756457588661 0.32531109709226 no 2259 0.327233736790739 744 3132057 YMR211W DML1 SGTC_1603 st002045 67.8 µM -0.447805192915248 0.32522379502221 no 2260 0.327146897674874 743 5887985 SGTC_2469 5655019 90.81 µM -0.45084414869482 0.324122010370437 no 2261 0.326050939755964 751 2788239 SGTC_1826 st055655 41.6 µM -0.45093270566366 0.324089926740278 no 2262 0.326019025355272 724 676168 SGTC_2144 5628481 200 µM -0.45124632015988 0.323976316697315 no 2263 0.325906014361748 731 2818399 SGTC_2749 bexarotene 57.39 µM -0.451822614710281 0.323767590879016 no 2264 0.325698388302356 733 82146 An retinoic acid receptor inhibitor. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.452030650739083 0.323692256751131 no 2265 0.325623450841924 730 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_88 0180-0332 8.668 µM -0.452325372581283 0.323585544272409 no 2266 0.325517300013698 723 3101745 SGTC_1607 st000305 50.6 µM -0.45235593954319 0.323574477459034 no 2267 0.325506291431355 766 5457690 SGTC_1347 1493-0251 600 nM -0.452993811708188 0.323343570522389 no 2268 0.325276598789209 736 3986378 SGTC_1898 st060199 18.6 µM -0.454218035325218 0.3229005975504 no 2269 0.3248359516619 716 688866 SGTC_2199 6590217 200 µM -0.454261610289902 0.322884835013566 no 2270 0.324820271797932 711 703109 SGTC_409 arachidonic acid 100 µM -0.455428295565238 0.322462923905853 no 2271 0.324400571296457 730 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1133 3473-0247 50 µM -0.456380086697484 0.322118894712227 no 2272 0.32405834139662 747 711311 SGTC_3007 9078383 71.4286 µM -0.457342620201938 0.32177113757523 no 2273 0.323712400077246 728 6496995 SGTC_2221 6807166 181.081 µM -0.457458166625556 0.321729401885338 no 2274 0.323670882109482 737 674925 SGTC_1209 2323-2347 50.3 µM -0.457757706660181 0.321621217666014 no 2275 0.323563262052648 715 5412760 SGTC_2892 9047358 58.44 µM -0.458988578810938 0.321176825114997 no 2276 0.323121183887488 762 6466771 SGTC_153 4077-0274 519.67 µM -0.459241348745632 0.321085597028813 no 2277 0.323030430308006 689 3121976 SGTC_1126 isoteolin 1.0172 µM -0.459527502711434 0.320982333225478 no 2278 0.322927703363202 727 133323 SGTC_2186 6124449 200 µM -0.45955022945264 0.320974132465663 no 2279 0.32291954522697 727 3834182 YLR033W RSC58 SGTC_1684 st024538 14.6195 µM -0.46181664040282 0.320156755665227 no 2280 0.322106408342775 737 6732859 SGTC_1407 3909-7909 12.3 µM -0.464139420149166 0.319319954237643 no 2281 0.321273930275511 729 4411780 SGTC_278 4092-0821 23.9 µM -0.464753450235975 0.319098898095078 no 2282 0.321054013289868 768 877900 SGTC_2807 7945238 51.95 µM -0.466275180099672 0.318551339502152 no 2283 0.320509271099603 771 17148797 SGTC_2163 5671233 125 µM -0.466831317006996 0.318351325506501 no 2284 0.320310284001298 709 701023 SGTC_2049 5262831 67.185 µM -0.468376869004018 0.317795747658116 no 2285 0.31975755324742 750 763417 SGTC_1294 1000-1494 117 µM -0.469027579337938 0.317561960100102 no 2286 0.319524961408493 716 712797 YDL207W GLE1 SGTC_1885 st057546 99.9 µM -0.469996717295673 0.317213902555247 no 2287 0.319178681448581 737 702008 SGTC_2268 7933382 153.85 µM -0.470143536263213 0.317161187877286 no 2288 0.319126235723936 725 935025 YOR257W CDC31 SGTC_2739 tacrine 100.86 µM -0.471131414373166 0.316806591266027 no 2289 0.318773446443931 743 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3121 9125696 49.47 µM -0.471637280235881 0.316625076969421 no 2290 0.318592856059402 762 1235365 SGTC_2674 ligustilide 100 µM -0.472200206756582 0.316423140122779 no 2291 0.318391946086429 721 5319022 A signalling regulator. SGTC_1093 fluphenazine 7.97 µM -0.472378537267027 0.316359179594574 no 2292 0.318328310587803 772 6602611 An atypical antipsychotic. SGTC_2363 9053361 176 µM -0.472407059877739 0.316348950103377 no 2293 0.318318133070314 768 6469797 YMR079W SEC14 SGTC_2925 9010536 32.5 µM -0.472826045053773 0.316198699369864 no 2294 0.318168645417704 750 2994177 SGTC_41 0478-0632 82.643 µM -0.472958199181857 0.316151314357805 no 2295 0.31812150094072 782 3750424 SGTC_1884 5633444 25 µM -0.473351674149632 0.316010248367054 no 2296 0.317981150686199 736 5724239 SGTC_3117 9124945 49.47 µM -0.478053882426468 0.314326521828893 no 2297 0.316305927449787 747 17592065 SGTC_1424 4048-1941 275 µM -0.478967849575493 0.313999702760514 no 2298 0.315980750418936 751 X1424 SGTC_1404 3909-7820 48.3 µM -0.479055776938959 0.313968269120442 no 2299 0.315949474564802 758 23741373 SGTC_1254 0550-0035 264 µM -0.479431540405235 0.313833950570756 no 2300 0.31581582995829 744 15121435 SGTC_1922 5578187 25 µM -0.479729948682888 0.313727300596059 no 2301 0.315709714765685 703 1350412 SGTC_2697 mebhydrolin 72.4 µM -0.481320283011104 0.313159183878362 no 2302 0.315144441802764 740 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_110 0850-0284 111.64 µM -0.481907607455978 0.312949485375169 no 2303 0.314935790835309 745 3906265 SGTC_786 4544-0069 423 µM -0.483450917349595 0.312398750023654 no 2304 0.314387801170971 721 748821 YLR208W SEC13 SGTC_2011 4012611 177 µM -0.484152441204414 0.312148547236692 no 2305 0.314138843142211 752 2049887 SGTC_377 3970-0964 33.1 µM -0.485121264041272 0.31180315305734 no 2306 0.313795164596041 756 16481235 SGTC_445 e6 berbamine 66 µM -0.486208261636852 0.31141582546207 no 2307 0.313409757189582 771 6610268 A calcium/calmodulin antagonist. SGTC_1017 4239-0030 168 µM -0.487059957762561 0.311112488104998 no 2308 0.313107920874134 730 1149593 SGTC_332 4112-0506 40.9 µM -0.48854248764532 0.310584781037034 no 2309 0.312582819326346 755 2790355 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.488570564304118 0.310574790894894 no 2310 0.312572878438764 762 688669 SGTC_1710 st031758 61.5 µM -0.490912494356541 0.309741985620656 no 2311 0.311744169837176 763 5394341 SGTC_1992 st073643 23.3 µM -0.491590520163795 0.309501057247015 no 2312 0.311504423177394 764 3161292 SGTC_3135 9127742 49.47 µM -0.491609440448358 0.309494335323278 no 2313 0.311497734201379 744 3643468 SGTC_1859 st055998 20 µM -0.491981122282838 0.309362298600047 no 2314 0.311366344415802 778 676301 SGTC_2581 avocatin a 64 µM -0.492413698389098 0.309208660708032 no 2315 0.31121345871408 788 6710728 A skin care supplement. SGTC_1506 4226-2149 212 µM -0.492413781073891 0.309208631344093 no 2316 0.311213429493843 756 991114 SGTC_3266 9136860 49.47 µM -0.493390395842512 0.30886189015813 no 2317 0.310868383585339 746 4871271 YPR165W RHO1 SGTC_2982 9019404 25.97 µM -0.494021472552693 0.308637920724143 no 2318 0.310645507464786 729 22333232 SGTC_1658 st012944 20 µM -0.495263323649383 0.308197395037873 no 2319 0.310207128289611 771 24207260 SGTC_3192 9110362 49.47 µM -0.495936045014958 0.307958873764279 no 2320 0.309969767060442 762 16649480 SGTC_2887 9044784 58.44 µM -0.497028395983995 0.30757174068198 no 2321 0.30958451353062 756 6465546 SGTC_1747 st037496 66.6 µM -0.497896847723286 0.307264111105529 no 2322 0.309278374627926 764 723305 SGTC_1480 1070-0044 41.2 µM -0.49816387278467 0.307169550698895 no 2323 0.309184271916399 754 3124987 SGTC_561 1550-0330 72.9 µM -0.499627487137089 0.30665147527174 no 2324 0.308668699800176 760 6812934 SGTC_1628 st004252 77.7 µM -0.501563989674011 0.305966605057274 no 2325 0.307987127652142 724 692968 SGTC_2092 5303694 80.6725 µM -0.501665739365284 0.305930638630972 no 2326 0.307951334073117 757 1963699 SGTC_1531 st059297 52.4 µM -0.501876772880267 0.305856048582952 no 2327 0.307877102377151 746 7566702 SGTC_3001 9076041 71.4286 µM -0.503109224965257 0.305420597828669 no 2328 0.307443740622023 751 16004211 SGTC_412 gemfibrozil 100 µM -0.503334568191363 0.305341009153304 no 2329 0.307364533199285 740 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2313 7726885 200 µM -0.50433427432425 0.304988035262724 no 2330 0.307013248064893 746 726423 SGTC_2817 7995342 71.43 µM -0.504441936058952 0.304950033122637 no 2331 0.306975427537351 790 18879975 SGTC_1611 st001856 99.4 µM -0.504858590367501 0.304802983468537 no 2332 0.306829080261501 789 647478 SGTC_2797 7859098 81.82 µM -0.509102280224513 0.303307058594373 no 2333 0.305340266799485 756 972681 SGTC_2755 lomerizine 42.69 µM -0.510111262489568 0.30295187002215 no 2334 0.304986757656869 756 3949 A calcium channel blocker. SGTC_3006 9075424 71.4286 µM -0.510439199023084 0.302836467745508 no 2335 0.304871900280613 763 7465181 SGTC_3088 9117578 49.47 µM -0.510655267898023 0.302760442937548 no 2336 0.304796234240459 783 678341 SGTC_1258 0671-0043 57.1 µM -0.511516766844445 0.30245740567332 no 2337 0.304494625438964 789 4298767 SGTC_2393 9031399 185.94 µM -0.512038120731823 0.302274082493982 no 2338 0.304312165170911 776 1526623 YDL150W RPC53 SGTC_2170 morpholine 200 µM -0.512099309617866 0.302252569972721 no 2339 0.30429075384876 763 121171 Reacts with secondary amines. SGTC_57 miconazole 162.5 nM -0.512212512992507 0.302212772236139 no 2340 0.304251143294507 773 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2626 ethyl orsellinate 100 µM -0.512673233506205 0.302050825770886 no 2341 0.3040899580631 773 75653 A natural product. SGTC_955 1216-0110 33 µM -0.5145156074559 0.301403608396576 no 2342 0.303445775636331 756 3619719 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.51546318802345 0.301070971054284 no 2343 0.303114693541763 768 4620898 SGTC_3094 9117742 49.47 µM -0.515814975147212 0.30094752232746 no 2344 0.302991821210096 805 17149698 SGTC_1487 3970-0795 2.82 µM -0.516201200697932 0.300812014798785 no 2345 0.302856945887427 756 3765103 SGTC_1892 st058411 7.36 µM -0.517722952111338 0.300278375242141 no 2346 0.302325790984452 793 3934738 SGTC_2596 sinensetin 100 µM -0.517724770410363 0.300277737866891 no 2347 0.302325156572056 744 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1019 4262-0212 3.4 µM -0.519168819738615 0.299771743002821 no 2348 0.301821510218005 775 4677213 SGTC_1417 3966-0327 90.4 µM -0.519501726458172 0.299655147283206 no 2349 0.301705454636208 766 651118 SGTC_1786 berberine 21.6 µM -0.520748817017533 0.299218554770272 no 2350 0.301270881247091 761 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_657 3534-0529 86.7 µM -0.521300152990972 0.299025630242749 no 2351 0.301078847220901 779 1049549 SGTC_2582 agaric acid 100 µM -0.521611697323601 0.298916639042385 no 2352 0.300970358634732 766 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2893 9048488 25.97 µM -0.521786639033708 0.298855445049173 no 2353 0.300909446690252 751 6467338 SGTC_817 1391-0715 46 µM -0.522171700574311 0.298720771937185 no 2354 0.300775393923699 789 1353946 SGTC_1977 st070720 65.3 µM -0.522239572107863 0.298697037109529 no 2355 0.300751768372383 750 682188 SGTC_1192 1488-0095 21.4 µM -0.523122512726116 0.298388348948725 no 2356 0.300444499965395 794 915875 SGTC_1652 st011932 78 µM -0.523608744974781 0.298218417498346 no 2357 0.3002753489232 774 1551076 SGTC_2607 solasodine 47.35 µM -0.524460448552783 0.297920865133265 no 2358 0.299979161076959 752 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2008 4012253 172 µM -0.524975987514501 0.297740821499496 no 2359 0.299799941859398 745 603940 SGTC_2805 7950783 58.44 µM -0.525186835994986 0.297667200386827 no 2360 0.299726657588944 753 1178958 YDL195W SEC31 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.52651113619741 0.297204989887164 no 2361 0.299266558312007 782 4213774 SGTC_2128 5255449 168.493 µM -0.52661440516161 0.297168960492562 no 2362 0.29923069322992 747 736008 SGTC_770 0389-1121 67.2 µM -0.526734352155172 0.297127114825354 no 2363 0.299189038353583 753 6753108 SGTC_2803 7707263 71.43 µM -0.529090475744237 0.296305685521221 no 2364 0.298371344060342 759 2199229 SGTC_1310 1188-0297 994 nM -0.530551299372174 0.295796913487531 no 2365 0.297864875625923 765 1588352 SGTC_493 zm226600 134 µM -0.531292824161697 0.295538810724085 no 2366 0.297607938624264 799 5240098 A potassium channel opener. YCR052W RSC6 SGTC_788 1182-0090 188 µM -0.532223326529132 0.295215077063755 no 2367 0.297285664424284 755 5715185 SGTC_2999 9069765 71.4286 µM -0.533193769283162 0.294877621646806 no 2368 0.29694972708411 766 2097066 SGTC_1105 epirubicin 18.1 µM -0.533224875255391 0.294866808000698 no 2369 0.296938962029433 756 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2540 epiandrosterone 100 µM -0.53368780074657 0.294705898695547 no 2370 0.296778775372183 768 441302 A steroid. SGTC_789 1309-1135 70.6 µM -0.533885208399947 0.294637293647003 no 2371 0.296710478201112 751 3092424 SGTC_821 1114-0266 29.2 µM -0.535784081257469 0.29397775526934 no 2372 0.296053892605412 767 3123235 SGTC_2249 haloperidol 116.36 µM -0.538064095892285 0.293186737476183 no 2373 0.295266399421827 789 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_298 1391-0729 10 µM -0.538170496147335 0.293149847574191 no 2374 0.2952296734447 769 3237558 SGTC_2293 7624732 200 µM -0.540682129700533 0.292279667965159 no 2375 0.294363348948472 782 894453 SGTC_1326 1431-2094 10.8 µM -0.540812857860228 0.292234408849593 no 2376 0.294318289730003 796 616278 SGTC_2687 chenodiol 100 µM -0.542283778840624 0.291725389325522 no 2377 0.293811514225614 748 5702181 A cholesterol synthesis inhibitor. SGTC_2300 7976697 71.57 µM -0.542454587053932 0.291666307080057 no 2378 0.293752691947178 754 2236109 SGTC_2869 9037858 32.47 µM -0.542572104900426 0.291625661113125 no 2379 0.293712224765842 755 27187042 SGTC_1411 3909-8223 150 µM -0.542583819834211 0.291621609406807 no 2380 0.293708190878694 788 X1411 SGTC_883 0850-0245 24.6 µM -0.543105401275691 0.291441242771533 no 2381 0.293528616991117 781 6823229 YPR165W RHO1 SGTC_2966 9084041 48.03 µM -0.543175948718979 0.291416850951311 no 2382 0.293504332303605 768 17741380 SGTC_2988 9073640 71.4286 µM -0.54396726105142 0.291143319522359 no 2383 0.293232001054993 799 9102229 SGTC_642 0335-0876 158 µM -0.544949314496166 0.290804021798759 no 2384 0.292894188977804 784 6812350 SGTC_1896 st058441 89 µM -0.545576545241837 0.290587411477362 no 2385 0.292678525307491 748 688759 SGTC_328 k915-0120 63.5 µM -0.545736252490645 0.290532269611044 no 2386 0.292623624203492 763 6624543 SGTC_2257 7960413 200 µM -0.545953023852964 0.290457433144166 no 2387 0.292549114344721 773 2974689 YIL048W NEO1 SGTC_1324 1418-0026 34.4 µM -0.546149903864807 0.290389471633322 no 2388 0.292481449292499 787 1372513 SGTC_2655 perillic acid 100 µM -0.547040658701814 0.290082082792236 no 2389 0.292175399601521 786 5702197 An apoptosis inducer. SGTC_1600 coumarin 106 71.1 µM -0.547715586743901 0.289849274799556 no 2390 0.291943603959586 804 100336 A hepatotoxic, DNA x-linker. SGTC_3244 9134489 49.47 µM -0.547985010926102 0.289756364777432 no 2391 0.29185109749654 800 16584271 SGTC_802 4112-3352 742 µM -0.547999731317318 0.28975128890272 no 2392 0.291846043661659 751 704594 SGTC_3181 9108277 49.47 µM -0.548223681993275 0.289674071538047 no 2393 0.291769161485142 795 17097298 SGTC_1981 st071826 47 µM -0.548602733400934 0.289543398027695 no 2394 0.291639054799125 746 11838600 SGTC_2228 7354201 200 µM -0.548627525882029 0.289534852076223 no 2395 0.291630545899657 796 753451 SGTC_124 0136-0217 7.121 µM -0.549109855196674 0.289368617059311 no 2396 0.291465031177505 790 3976905 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.552301988774235 0.288269578867847 no 2397 0.290370734130351 805 7104 SGTC_1965 Pectolinarigenin 58.4 µM -0.553373198501421 0.287901207516624 no 2398 0.290003943716279 781 5320438 An anti-inflammatory. SGTC_2640 pentamidine 10.38 µM -0.554087179364964 0.287655804795742 no 2399 0.289759591901361 792 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2198 6589944 200 µM -0.554250684573063 0.287599620253518 no 2400 0.289703647704623 760 5290268 SGTC_1088 bifonazole 369 nM -0.554322063313131 0.287575094332218 no 2401 0.289679226669861 777 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1205 4161-2785 76 µM -0.556123532065963 0.286956432588795 no 2402 0.289063204606106 787 3498106 SGTC_2378 9074213 121.43 µM -0.556333756698311 0.286884278190108 no 2403 0.288991357312109 776 657714 SGTC_3304 9125678 46.087 µM -0.556727644075525 0.286749109251571 no 2404 0.288856763253398 786 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_864 0469-0573 172 µM -0.557408592655191 0.286515501774983 no 2405 0.288624148002401 795 689425 SGTC_2777 climbazole 1.536 µM -0.564223365754465 0.28418260105713 no 2406 0.286301063965011 790 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_77 0828-0286 12.516 µM -0.564298846683996 0.28415681261557 no 2407 0.286275383098934 776 745345 SGTC_1617 st002906 78 µM -0.564366290999315 0.284133770870681 no 2408 0.286252437454312 772 5150859 SGTC_245 methotrexate 289.6 µM -0.565389348228292 0.28378436217746 no 2409 0.285904484017608 764 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_171 k064-0041 9.68 µM -0.568096920354656 0.282860628622786 no 2410 0.28498457940078 770 53325 SGTC_2760 etidronate 98.04 µM -0.569254883170501 0.282466011567731 no 2411 0.284591589923824 788 3305 A chelator and antioxidant. SGTC_519 k048-0011 62.8 µM -0.569349803935181 0.282433675681883 no 2412 0.284559387189207 771 6836379 SGTC_2939 9044578 71.43 µM -0.569670688729333 0.282324375649827 no 2413 0.284450536984801 780 2653634 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.570104455895175 0.282176657891596 no 2414 0.284303426567212 795 279621 SGTC_1853 st056710 91.2 µM -0.571469408272159 0.281712071434695 no 2415 0.283840745779978 792 269167 SGTC_2703 st077852 53.4 µM -0.573939259461125 0.280872351028492 no 2416 0.283004452512993 808 6281836 SGTC_1501 4491-0275 38.4 µM -0.574664519082353 0.280626001298835 no 2417 0.282759103973174 792 5104718 SGTC_1824 st053723 68.6 µM -0.574845437288049 0.280564564908923 no 2418 0.282697916966955 797 675225 SGTC_1911 st060208 74.3 µM -0.574938949346607 0.280532812539823 no 2419 0.282666293440675 794 688783 SGTC_1954 st077032 68.9 µM -0.575085607446609 0.280483017736513 no 2420 0.282616700627206 819 698907 SGTC_141 0443-0274 32.331 µM -0.575118323968348 0.280471910084333 no 2421 0.282605638021855 769 1627241 SGTC_2810 7959871 45.46 µM -0.575512543641064 0.280338084512619 no 2422 0.28247235486858 782 2974535 SGTC_1179 1021-1431 9.29 µM -0.576748159163364 0.279918831143508 no 2423 0.282054797119064 806 2840958 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.577552333065674 0.2796461325041 no 2424 0.281783198370582 764 6312947 SGTC_466 geldanamycin 89.2 µM -0.577791884498818 0.279564924572496 no 2425 0.281702317521029 772 5288382 HSP90 inhibitor. SGTC_1193 1488-0126 41.5 µM -0.577905434257769 0.2795264352063 no 2426 0.281663983105305 772 1384710 SGTC_598 3937-0236 20.2 µM -0.577935329133265 0.279516302325045 no 2427 0.28165389100913 807 1379313 SGTC_2737 bleomycin 30.5 nM -0.580104302952956 0.278781603990004 no 2428 0.280922141098571 795 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_128 0906-2981 13.371 µM -0.58013954378541 0.278769674597165 no 2429 0.280910259437001 800 6740226 SGTC_602 3130-1533 38.1 µM -0.58029608792631 0.278716685760721 no 2430 0.280857482561547 802 720941 SGTC_793 0488-0545 106 µM -0.580593540038224 0.27861601430821 no 2431 0.280757213557278 802 292548 SGTC_1189 1431-2119 7.28 µM -0.58181632092439 0.278202355229643 no 2432 0.280345204720082 806 3107275 SGTC_1966 st070145 16.1 µM -0.582303710801157 0.27803755781829 no 2433 0.280181063213578 797 3748532 SGTC_2889 9059656 51.95 µM -0.582813398712617 0.277865271905511 no 2434 0.280009462074523 792 3949838 SGTC_686 1319-0111 510 µM -0.582940942024592 0.277822167567362 no 2435 0.279966528910684 842 4562600 SGTC_3092 9117248 49.47 µM -0.583971290952344 0.277474072218525 no 2436 0.279619813706287 798 17141857 SGTC_981 1488-1094 54.9 µM -0.585514763629881 0.276953021204596 no 2437 0.279100821254318 795 3449522 SGTC_2215 7188065 200 µM -0.586090348421082 0.276758835941849 no 2438 0.278907400925066 798 940217 SGTC_1436 4092-1007 8.32 µM -0.588391036682834 0.275983318669854 no 2439 0.278134926340338 765 2881121 SGTC_277 nystatin 15.5 µM -0.589114132224502 0.27573979783986 no 2440 0.277892356902912 803 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2673 kobusone 100 µM -0.589603906612272 0.275574913862121 no 2441 0.277728115997516 807 6710676 An epoxy ketone and protein crosslinker. SGTC_2584 androsterone 48.74 µM -0.591367507739252 0.274981594322435 no 2442 0.277137103129949 775 2754130 A steroid. SGTC_1102 cgs 12066b 26.1 µM -0.592698629582916 0.274534188808618 no 2443 0.276691429372504 775 6438352 A 5-HT1B full agonist. SGTC_2202 7226349 200 µM -0.592918098638848 0.274460457213545 no 2444 0.276617982535786 771 844334 SGTC_117 lucigenin 22.078 µM -0.594241108933531 0.274016193206829 no 2445 0.276175430526812 815 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1104 tacrolimus 29.8 µM -0.594269082832819 0.27400680346962 no 2446 0.276166076903255 793 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_415 dibenzyl ketone 100 µM -0.594644080148866 0.273880946982293 no 2447 0.276040704188592 810 7593 SGTC_1403 3909-7815 62.9 µM -0.594704269057348 0.273860749060875 no 2448 0.276020583856099 781 6615483 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.595275446267094 0.273669112662632 no 2449 0.275829682944884 824 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1678 st019265 80.2 µM -0.595783334004503 0.273498766337914 no 2450 0.275659989377382 795 5367020 SGTC_539 4859-0462 2.54 µM -0.595937895399957 0.273446936627795 no 2451 0.275608358085059 785 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1440 4100-1550 40 µM -0.596437795434547 0.27327933639202 no 2452 0.275441398857845 808 742806 SGTC_2072 5231554 129 µM -0.597633099938067 0.272878796041508 no 2453 0.275042386650148 804 789545 SGTC_497 capsazepine 133 µM -0.597748059365125 0.272840289085928 no 2454 0.275004026325627 771 2733484 A calcium channel blocker. SGTC_2706 st078239 82.5 µM -0.600412925047747 0.271948418427559 no 2455 0.274115538012664 802 15434492 SGTC_606 k015-0008 38.6 µM -0.601256091284129 0.271666531933418 no 2456 0.273834715026177 813 1970475 SGTC_2097 5376186 200 µM -0.601403159045313 0.271617379289172 no 2457 0.273785747553823 777 742755 SGTC_2053 5265679 138 µM -0.604241725508231 0.270669548638351 no 2458 0.27284147179418 815 764595 SGTC_745 0469-0705 296 µM -0.604245343956189 0.270668341451028 no 2459 0.27284026911522 812 3486736 SGTC_801 0866-0028 10.1 µM -0.60573477728214 0.270171664858195 no 2460 0.272345443241749 802 6849771 SGTC_1415 3966-0071 78.1 µM -0.605742931337102 0.270168947006534 no 2461 0.272342735494457 798 2893185 SGTC_2691 st077356 60.2 µM -0.606495735834241 0.269918086484762 no 2462 0.272092806541145 803 2839272 SGTC_2200 6600604 21.907 µM -0.606720651994893 0.269843159260336 no 2463 0.272018157145475 832 2904777 SGTC_45 0kpi-0036 14.9 µM -0.606946468243013 0.269767942663456 no 2464 0.271943219259174 810 2795021 SGTC_616 4092-0450 108 µM -0.608852825531897 0.269133377396014 no 2465 0.271310997699099 817 787165 SGTC_1708 st033234 31.827 µM -0.610087518270558 0.268722787735066 no 2466 0.270901917220796 791 674664 SGTC_462 ag-879 158 µM -0.610296816389101 0.268653218108185 no 2467 0.270832602738421 814 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_97 0535-0701 19.132 µM -0.610814899190087 0.268481048965197 no 2468 0.270661064310848 784 2832013 YGL099W LSG1 SGTC_3307 9126885 69.2785 µM -0.610979258648262 0.268426440665327 no 2469 0.27060665584886 785 24824909 SGTC_2796 7949634 45.45 µM -0.612758735182418 0.267835568798772 no 2470 0.270017939746738 803 2971588 SGTC_2027 5150920 200 µM -0.613570890766385 0.267566111975399 no 2471 0.269749462052942 789 786715 SGTC_1413 3910-0535 34.4 µM -0.616125156630127 0.266719549951437 no 2472 0.268905959962927 796 2876951 SGTC_1661 st013063 9.66 µM -0.617431809709003 0.266287009096011 no 2473 0.268474973009441 826 721395 SGTC_2437 5741531 144.16 µM -0.619629606591217 0.265560274910682 no 2474 0.267750835036575 823 2262990 SGTC_646 4092-0839 27.3 µM -0.621155265354185 0.265056385418275 no 2475 0.267248734891832 814 877796 SGTC_3325 9138760 55.175 µM -0.626243225085722 0.263379469209385 no 2476 0.265577709667064 793 43844959 SGTC_1840 st055363 71 µM -0.626578253004131 0.263269239348389 no 2477 0.265467863585892 811 676033 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.627517630336738 0.262960293991224 no 2478 0.265159991581156 797 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_72 0744-0168 198.391 µM -0.627559494718981 0.262946529817242 no 2479 0.265146275148985 823 677577 SGTC_3295 9122362 53.5725 µM -0.629250611835429 0.262390832342855 no 2480 0.264592499552391 824 4730473 SGTC_1839 st053978 48 µM -0.63060869876013 0.261945003663261 no 2481 0.264148204865916 812 3788398 SGTC_2824 7998404 51.95 µM -0.631636109851432 0.26160798649696 no 2482 0.263812342614727 828 837851 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.631877438449018 0.261528856821469 no 2483 0.263733483521115 832 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2506 ethyl hematommate 54.16 µM -0.632098438950283 0.261456403342627 no 2484 0.263661277599604 806 3940691 An allergen. SGTC_2286 7945697 125 µM -0.632503013165843 0.261323793206572 no 2485 0.263529120078463 803 1245733 SGTC_3185 9108267 49.47 µM -0.633819383732517 0.260892556387152 no 2486 0.263099350788473 812 4910486 SGTC_980 1473-0395 201 µM -0.636362554216912 0.260060463524513 no 2487 0.262270070800118 822 768876 SGTC_2333 9017922 200 µM -0.636802823231867 0.259916552202998 no 2488 0.262126643449445 821 3163164 SGTC_1837 st055472 66.5 µM -0.638061850324462 0.259505239147017 no 2489 0.261716709524292 796 676091 SGTC_1029 k015-0030 64.7 µM -0.638980041379967 0.259205486323017 no 2490 0.261417957930746 808 2208316 SGTC_1810 st050138 53 µM -0.640165569123034 0.258818723596477 no 2491 0.261032482270523 840 3444541 SGTC_2681 menadione 3.18 µM -0.640165963049347 0.258818595132883 no 2492 0.26103235423353 826 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2484 5809818 12.04 µM -0.640700252520183 0.258644387982886 no 2493 0.260858725040742 807 2870548 SGTC_2735 sertaconazole 140 nM -0.640741087353539 0.258631076125021 no 2494 0.260845457301679 835 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3123 9126162 49.47 µM -0.640938845248865 0.258566613512476 no 2495 0.260781208243417 793 25239884 SGTC_1140 3229-1848 2.98 µM -0.642665936333495 0.258003992083492 no 2496 0.260220444289438 816 2849525 SGTC_2381 9035592 200 µM -0.642683538776217 0.257998261139219 no 2497 0.260214732206522 813 4749657 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.643308083218848 0.257794966795313 no 2498 0.260012106160386 838 5282309 SGTC_1479 0549-0158 134 µM -0.643440605030521 0.257751840552331 no 2499 0.25996912149465 796 5440202 SGTC_2470 5664817 21.68 µM -0.645481005435296 0.2570883111447 no 2500 0.25930776180938 818 2859561 SGTC_346 4513-0042 7.16 µM -0.645776638391741 0.256992246316061 no 2501 0.259212009777387 803 2827372 SGTC_2171 5739187 198.077 µM -0.650076939235113 0.255596993804774 no 2502 0.257821262180925 800 2262761 SGTC_917 harmaline 728.087 nM -0.650149808679232 0.255573385112766 no 2503 0.257797729099053 796 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3356 9151811 4.48 µM -0.651205079276387 0.255231619764191 no 2504 0.257457055996073 834 1859254 YPR165W RHO1 SGTC_2403 6032726 181.2 µM -0.651670846286788 0.255080850116314 no 2505 0.257306766819302 808 2881040 SGTC_695 3505-6186 243 µM -0.652747931738739 0.254732374062142 no 2506 0.256959398063665 825 1819379 SGTC_1522 st012842 45.6 µM -0.652821466597138 0.254708591972164 no 2507 0.256935691378268 818 3491067 YOR116C RPO31 SGTC_2336 9001819 198.65 µM -0.653013561400657 0.254646471603777 no 2508 0.256873767872563 826 2989602 SGTC_3120 9124077 49.47 µM -0.654490144509829 0.254169233424116 no 2509 0.25639803730487 828 18774327 YGL155W CDC43 SGTC_1899 st063254 59.6 µM -0.654822227472497 0.254061967388917 no 2510 0.256291108960804 809 3093813 SGTC_2247 cerulenin 830 nM -0.655976450376845 0.253689326931048 no 2511 0.255919638304182 799 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3019 9081971 49.47 µM -0.656097785317835 0.25365017066743 no 2512 0.255880604660013 823 16451803 SGTC_2397 5161689 200 µM -0.657258580218153 0.253275728513643 no 2513 0.255507332193832 828 2259942 SGTC_967 1306-0166 352 µM -0.657445179549445 0.253215563562611 no 2514 0.255447354697919 827 4437607 SGTC_1519 esterone 74 µM -0.657785973033679 0.253105701415275 no 2515 0.255337834496871 824 698 A steroid. SGTC_530 4358-1714 28 µM -0.658461479759804 0.25288801134573 no 2516 0.255120820652381 815 1564641 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.658550512289283 0.252859326907237 no 2517 0.255092225185748 811 688664 SGTC_1505 k297-0037 20.6 µM -0.658789935807473 0.252782198100786 no 2518 0.255015335460189 808 4089396 SGTC_1886 st057356 49.9 µM -0.658792843829304 0.252781261375672 no 2519 0.255014401637327 809 24207747 SGTC_622 1348-1566 26.3 µM -0.659118228024416 0.252676460932263 no 2520 0.254909925688715 816 7340407 SGTC_3202 9113761 49.47 µM -0.659219359841664 0.252643892840412 no 2521 0.254877458353802 817 4798415 SGTC_964 1287-0107 19.4 µM -0.659824304384513 0.252449125062616 no 2522 0.254683292303224 803 51516812 YPR165W RHO1 SGTC_1389 3405-0187 19 µM -0.662189780184911 0.251688297424127 no 2523 0.253924801521562 809 799890 SGTC_321 4534-3890 65.3 µM -0.662435959583407 0.251609186329557 no 2524 0.253845932160289 823 699746 SGTC_2516 gossypol 71.55 µM -0.663111629521763 0.251392123622771 no 2525 0.253629531498597 825 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1046 2001-0062 216 µM -0.665771717608535 0.250538518438625 no 2526 0.252778512502941 833 739778 SGTC_188 3229-0966 278.469 µM -0.666480558061522 0.250311315497696 no 2527 0.252551993257634 824 5722370 SGTC_2698 st077697 67.5 µM -0.667764221039619 0.249900144255585 no 2528 0.252142054302354 822 3154499 SGTC_849 0386-0493 241 µM -0.669032520134099 0.249494246584515 no 2529 0.251737366777832 834 726119 SGTC_196 k015-0023 18.111 µM -0.671417579991098 0.248731898364038 no 2530 0.250977274360484 812 5211998 SGTC_131 0141-0277 33.849 µM -0.67229948093913 0.248450326548157 no 2531 0.250696530071218 833 1547771 SGTC_655 k060-0012 42 µM -0.672481824131722 0.248392129526875 no 2532 0.250638503707378 834 5994525 SGTC_1256 0570-0116 285 µM -0.673415663974453 0.248094197245648 no 2533 0.25034144303864 827 410638 SGTC_2371 9071574 200 µM -0.673642591530847 0.248021827074711 no 2534 0.250269284072063 829 45596039 SGTC_1131 3454-3128 32.3 µM -0.67432969005216 0.247802771055228 no 2535 0.250050866109418 816 710982 SGTC_639 0833-0042 114 µM -0.674615426529139 0.247711704937067 no 2536 0.249960064698349 849 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_742 0kpi-0133 140 µM -0.674947817002169 0.247605792370264 no 2537 0.249854459589731 825 2728852 SGTC_2179 6298986 200 µM -0.67527101024487 0.247502833598909 no 2538 0.249751799285235 815 738374 SGTC_1571 st070080 73.4 µM -0.675633755671494 0.247387302049703 no 2539 0.249636602160718 826 4315245 SGTC_1393 3470-5649 58.2 µM -0.675639073919458 0.247385608444215 no 2540 0.249634913453792 809 4108395 SGTC_2683 piperine 63.03 µM -0.67627620574759 0.247182757534303 no 2541 0.249432648462073 833 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1631 benzylvanillin 81.9 µM -0.676402712917165 0.247142490594484 no 2542 0.249392497639914 810 75506 SGTC_1957 st077035 62.4 µM -0.676423089209666 0.247136005195725 no 2543 0.249386030937191 844 705593 SGTC_3260 9137109 49.47 µM -0.676462760501147 0.247123378815162 no 2544 0.249373440951128 809 17478346 SGTC_3355 9151058 44.0485 µM -0.676802508581993 0.24701525962473 no 2545 0.24926563315163 829 17015728 SGTC_379 3970-0972 5.9 µM -0.676810718552193 0.247012647251134 no 2546 0.249263028296231 830 2898042 YBL034C STU1 SGTC_2342 7990637 118.86 µM -0.677491922791743 0.246795942797137 no 2547 0.249046946575425 842 2033102 YER133W GLC7 SGTC_3255 9139072 49.47 µM -0.678595978426747 0.246444937273516 no 2548 0.248696945838679 830 17646060 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.679636152638603 0.246114486076838 no 2549 0.248367436196433 822 2724278 An inhibitor of dopamine biosynthesis. SGTC_522 1273-0010 11.6 µM -0.680759453712989 0.245757893522924 no 2550 0.248011854891154 827 5705015 SGTC_2878 9043973 25.97 µM -0.681735312526235 0.245448331902187 no 2551 0.247703167105274 844 6465167 SGTC_1781 st038725 66.3 µM -0.682777053068266 0.24511810265769 no 2552 0.247373865888476 837 4270275 YIL048W NEO1 SGTC_1950 st077106 7.18 µM -0.683016180335381 0.245042333623936 no 2553 0.247298309180029 812 13831864 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.683365194219308 0.244931768916632 no 2554 0.247188053899412 851 229346 A bile salt which induces apoptosis. SGTC_327 1273-0057 3.96 µM -0.683649074995954 0.244841857639017 no 2555 0.247098393892757 828 3108138 SGTC_439 amiodarone 34.4 µM -0.684028130170417 0.244721830240462 no 2556 0.246978701432734 834 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2677 mitomycin C 100 µM -0.685010791853948 0.24441081908427 no 2557 0.246668555513866 844 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1712 st032288 53.4 µM -0.685336479640272 0.24430778633297 no 2558 0.246565808558579 826 2883011 SGTC_391 gliotoxin 8.33 µM -0.685958799296861 0.244110977918791 no 2559 0.246369544891862 844 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2888 9058547 12.99 µM -0.687302356570848 0.24368637003618 no 2560 0.245946107059108 817 16476514 SGTC_3106 9121286 49.47 µM -0.688234307683411 0.243392077507344 no 2561 0.245652621285268 814 15943471 SGTC_2974 9094440 9.66 µM -0.689045141627835 0.243136187797854 no 2562 0.245397430256721 824 25236134 SGTC_189 3970-0742 2.116 µM -0.689239614686632 0.243074836010999 no 2563 0.245336245597268 826 2891807 SGTC_392 N-ethylmaleimide 8.33 µM -0.689713693145088 0.242925310225921 no 2564 0.245187126504666 818 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_697 0508-1955 564 µM -0.690016154350926 0.242829939051885 no 2565 0.245092014263289 827 6243113 SGTC_2836 9010338 19.48 µM -0.690929556315896 0.24254205087226 no 2566 0.244804905497555 823 2994051 SGTC_208 k072-0098 12.366 µM -0.691140687202369 0.242475532454138 no 2567 0.244738566697054 840 5948901 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.692529389742164 0.242038257342567 no 2568 0.24430246793757 848 688801 SGTC_2699 st077704 54.6 µM -0.693562468031141 0.241713238921988 no 2569 0.243978318911149 832 645852 SGTC_2915 7971052 15.16 µM -0.694299967080597 0.241481358164694 no 2570 0.243747055819567 810 5741558 SGTC_421 streptovitacin 30 mM -0.695349476170997 0.241151585180833 no 2571 0.243418157531868 855 91467 include heat shock SGTC_1235 benzylparaben 21.5 µM -0.695909816299206 0.240975617411018 no 2572 0.243242654708764 850 7180 SGTC_1364 1653-0028 37.6 µM -0.69591068899027 0.240975343407841 no 2573 0.243242381428591 820 5718652 SGTC_1964 st076914 61 µM -0.695920302747567 0.240972324939611 no 2574 0.243239370924905 862 24208661 SGTC_398 bronopol 33.3 µM -0.695996885541625 0.24094828068056 no 2575 0.243215390096008 821 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1568 digitonin 820 nM -0.696750392018444 0.240711776185489 no 2576 0.242979508269168 856 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2782 7736369 71.43 µM -0.697295513910988 0.240540756546571 no 2577 0.242808937481474 841 2950836 YOL077C BRX1 SGTC_3267 9137951 49.47 µM -0.697924155844908 0.240343616555864 no 2578 0.242612313427579 862 16643986 SGTC_1812 st052057 4.327 µM -0.698055617944966 0.240302401615456 no 2579 0.242571206152177 830 3645418 SGTC_715 0868-0130 184 µM -0.698426701475097 0.240186083270117 no 2580 0.242455191291618 842 2876258 SGTC_1129 3453-1384 223 µM -0.700180394446522 0.239636793158277 no 2581 0.24190732690424 851 1084452 SGTC_1339 1486-1321 22.7 µM -0.700719440271731 0.239468091584826 no 2582 0.24173906074558 836 3469382 SGTC_815 1582-0027 36.9 µM -0.702807662787036 0.238815167177566 no 2583 0.241087810581242 855 3128206 SGTC_1960 st011366 51.8 µM -0.703236127923618 0.238681319510366 no 2584 0.240954303977421 847 3972846 SGTC_1651 st011928 86.1 µM -0.70393689132072 0.238462497440157 no 2585 0.24073603791765 846 720198 SGTC_2402 5553605 200 µM -0.704262404049723 0.238360889422169 no 2586 0.240634687410735 855 6758546 SGTC_1759 st043059 70 µM -0.704794939006671 0.238194711049486 no 2587 0.240468929280572 856 669426 SGTC_2931 9014674 55.67 µM -0.705870459354784 0.237859286869375 no 2588 0.240134349886625 853 2996810 SGTC_2118 5526350 200 µM -0.706562191645471 0.237643692203266 no 2589 0.239919295764945 840 743594 SGTC_2302 7771753 200 µM -0.706894451365958 0.237540173765272 no 2590 0.239816036190525 831 2203047 SGTC_948 3448-0295 75.3 µM -0.707439630271703 0.237370372115357 no 2591 0.239646658198426 843 678569 SGTC_2765 myclobutanil 7.74 µM -0.707905716215283 0.237225257654026 no 2592 0.239501904856834 865 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3053 9095903 49.47 µM -0.709290857058647 0.236794285945272 no 2593 0.23907200049634 874 17174018 SGTC_590 k048-0076 22.4 µM -0.713349085485169 0.235534093919795 no 2594 0.237814885252248 849 6832814 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.713446187273774 0.235503986527376 no 2595 0.237784850558607 833 16623 A steroid. SGTC_1493 4348-0038 111 µM -0.714389691661586 0.235211554028895 no 2596 0.237493122211296 863 800424 SGTC_2058 5236698 133 µM -0.71517076816152 0.234969616687819 no 2597 0.237251764729324 830 766665 SGTC_3285 9112818 20.8695 µM -0.715441088963059 0.23488591724171 no 2598 0.237168265317556 849 17017947 YPR165W RHO1 SGTC_1583 clindamycin 39.6 µM -0.717792467898118 0.234158555107524 no 2599 0.236442629132224 853 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2560 caryophyllene 100 µM -0.719174158505279 0.233731733237673 no 2600 0.236016809695633 845 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_473 2-arachidonoylglycerol 10 µM -0.71991225185798 0.23350390361825 no 2601 0.235789512008694 830 5282280 An endocannabinoid. SGTC_871 0574-0004 149 µM -0.721277027047584 0.233082958751871 no 2602 0.235369544179966 852 9551173 SGTC_3239 9133757 49.47 µM -0.721928995485798 0.232882017475881 no 2603 0.235169066652404 871 17036923 SGTC_3115 9123671 49.47 µM -0.722660453288839 0.232656691613241 no 2604 0.23494425877596 856 3286988 SGTC_942 3253-1115 227 µM -0.723099203709902 0.23252159254146 no 2605 0.234809469239306 866 46497897 SGTC_1685 st024049 53.0905 µM -0.723183534385577 0.232495630622756 no 2606 0.234783566714866 847 1941139 SGTC_1518 st038567 90.8 µM -0.723206756628515 0.232488481740015 no 2607 0.234776434181913 868 77966 SGTC_826 1683-5028 118 µM -0.723813106823203 0.232301862316814 no 2608 0.234590240795213 847 722377 SGTC_984 1492-0255 2.91 µM -0.724222391100661 0.232175941982995 no 2609 0.234464607088625 836 1585198 SGTC_1731 st035964 63 µM -0.724296176990902 0.232153245070235 no 2610 0.234441961768001 880 6739575 SGTC_634 1611-4317 11.2 µM -0.725181741321757 0.231880937378921 no 2611 0.234170271342769 857 2843522 SGTC_1978 st071761 42 µM -0.726155560263599 0.231581697213449 no 2612 0.233871705840231 845 5147680 SGTC_699 0375-0592 111 µM -0.727329445188927 0.231221266023658 no 2613 0.233512082184697 804 762578 SGTC_1534 6-azauridine 81.6 µM -0.727795794617265 0.231078164384696 no 2614 0.233369299615367 840 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_139 0099-0334 718.624 µM -0.727981747596072 0.23102111757639 no 2615 0.233312379757611 868 97690 SGTC_2385 9074692 200 µM -0.730092905312933 0.230374006405787 no 2616 0.232666698853614 841 17046906 SGTC_2704 st078022 71.1 µM -0.731309410866292 0.230001584364138 no 2617 0.232295091768196 846 54697681 SGTC_3204 9114183 49.47 µM -0.732460093539227 0.229649623694262 no 2618 0.231943895769032 838 17027248 SGTC_2441 5730946 39.09 µM -0.732766339488003 0.229556002739562 no 2619 0.231850477312253 833 1774275 SGTC_946 3434-1334 87.4 µM -0.73345326063663 0.229346085222078 no 2620 0.231641012455419 839 4047976 SGTC_3222 9128301 49.47 µM -0.735811767794527 0.228626164219715 no 2621 0.230922629326627 831 4911358 SGTC_1857 st056007 79.3 µM -0.736362788100483 0.228458151454925 no 2622 0.230754972216591 841 619834 SGTC_3002 9075603 71.4286 µM -0.73763351703507 0.228070955386284 no 2623 0.230368591082375 849 20105405 SGTC_2927 9011802 47.9 µM -0.73812748807642 0.227920540154438 no 2624 0.230218490662062 834 43912568 SGTC_201 4262-0159 12.803 µM -0.738176980480392 0.227905472688871 no 2625 0.230203454677349 849 1341029 SGTC_487 nimodipine 119 µM -0.740083636685549 0.227325437173707 no 2626 0.229624623475907 831 4497 L-type voltage-gated calcium channels inhibitor SGTC_1947 st076332 61.6 µM -0.740095553716711 0.227321814438504 no 2627 0.229621008216074 864 24208416 SGTC_2522 biochanin a 4.94 µM -0.741078516907518 0.227023109137766 no 2628 0.229322917295116 837 5280373 A possible chelator. SGTC_1250 0485-0349 40.2 µM -0.741715813796102 0.226829564094802 no 2629 0.229129768239272 853 6842794 YDL195W SEC31 SGTC_2835 9006588 71.43 µM -0.742211513420514 0.226679086073865 no 2630 0.22897959695009 817 2345538 SGTC_1833 st055984 71 µM -0.743039735209757 0.226427791061098 no 2631 0.228728811943421 842 676288 SGTC_762 1165-0429 115 µM -0.744273474176628 0.226053747887122 no 2632 0.228355522721323 845 5967793 SGTC_2322 7413319 38.22 µM -0.745138545417207 0.225791685292064 no 2633 0.228093984667303 840 1840400 SGTC_852 0418-0143 439 µM -0.745440596072346 0.225700223285235 no 2634 0.228002705012068 843 5369229 SGTC_2979 9012552 45.46 µM -0.745997181184892 0.225531742252628 no 2635 0.227834558914103 868 17100905 SGTC_1388 3346-4487 254 µM -0.748620395728857 0.224738641402206 no 2636 0.227043017740705 870 3345614 SGTC_2283 7944793 200 µM -0.748691231853636 0.224717246812058 no 2637 0.227021664835395 841 2970533 SGTC_340 k038-0059 454 µM -0.749187135764749 0.224567501618359 no 2638 0.226872210829572 857 23733424 SGTC_468 gf-109203x 121 µM -0.749333799584548 0.224523225255265 no 2639 0.226828020372175 837 2396 A protein kinase C inhibitor. SGTC_1187 1391-0724 117 µM -0.750819901263527 0.224074865256832 no 2640 0.22638052534136 857 6997986 SGTC_2701 st077767 14.721 µM -0.752174493827478 0.223666625273801 no 2641 0.225973065079163 845 5721188 SGTC_1090 efavirenz 20.7 µM -0.752405760169192 0.223596969729063 no 2642 0.225903541824991 847 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_654 1124-0271 80.9 µM -0.753621358023316 0.223231044430054 no 2643 0.225538307904705 853 5403748 SGTC_728 3030-5151 22.5 µM -0.753908989365656 0.223144510113524 no 2644 0.225451936202999 855 3125388 SGTC_382 3229-0966 23.2 µM -0.754798526781102 0.222877012357605 no 2645 0.225184938988407 865 5722370 SGTC_1143 3454-2408 5.08 µM -0.754955159580593 0.222829929358731 no 2646 0.225137943756331 828 X1143 SGTC_1062 mesoridazine 14.2 µM -0.75718363101991 0.222160676698208 no 2647 0.224469927780539 835 4078 A neuroleptic. SGTC_2203 7227154 166.4 µM -0.757666225934679 0.222015895463435 no 2648 0.224325411406324 851 896304 SGTC_3229 9132204 49.47 µM -0.757795088151485 0.22197724517566 no 2649 0.224286831663594 864 17682924 SGTC_2816 7982706 58.44 µM -0.757963613435835 0.221926704344157 no 2650 0.224236382977379 861 2981853 SGTC_3248 9135562 49.47 µM -0.759858904864305 0.221358758038583 no 2651 0.223669464141152 857 17650701 SGTC_1958 st076513 41.9 µM -0.762645938893605 0.22052510225127 no 2652 0.222837289816902 878 732122 YGL099W LSG1 SGTC_2351 9026858 72.31 µM -0.762648466143826 0.22052434711917 no 2653 0.222836536012282 891 1409300 SGTC_3070 9117005 49.47 µM -0.76353930890918 0.220258259246146 no 2654 0.22257091427553 859 8779016 SGTC_22 0964-0034 14.468 µM -0.763753953064602 0.220194174222965 no 2655 0.222506941030895 868 138402 SGTC_758 0868-0029 16 µM -0.764537868954915 0.219960215997783 no 2656 0.222273389275908 836 762687 SGTC_3102 9121669 49.47 µM -0.764774564368189 0.2198896027421 no 2657 0.222202898205599 874 41905072 SGTC_890 0929-0006 47.2 µM -0.764837170052455 0.219870927787135 no 2658 0.222184255526332 869 1378169 SGTC_1405 3909-7894 12 µM -0.76510449936387 0.219791195065554 no 2659 0.222104660424905 839 7104060 SGTC_2959 9079155 11 µM -0.767086267062212 0.219200637665648 no 2660 0.221515113196124 871 16189457 SGTC_1836 st055642 81 µM -0.768584695708246 0.21875471925409 no 2661 0.221069946845537 866 8571 SGTC_2173 5763948 167 µM -0.768614999989102 0.218745706371226 no 2662 0.221060949068161 856 2867177 SGTC_2684 capsaicin 100 µM -0.771256298994031 0.217960971500494 no 2663 0.220277514913163 873 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2051 5263410 176 µM -0.771934871182397 0.217759628822212 no 2664 0.220076501336123 855 227584 SGTC_4 0960-0234 25.671 µM -0.771982070598345 0.217745628030547 no 2665 0.22006252335877 833 6821112 SGTC_102 gallobenzophenone 83.616 µM -0.774914395341324 0.216876829571089 no 2666 0.219195122645804 843 70837 SGTC_1067 clotrimazole 1.36 µM -0.777302423071406 0.216170780046845 no 2667 0.218490182903257 846 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2951 9072950 58.06 µM -0.779168477388594 0.215619985961427 no 2668 0.217940238223199 865 16488155 SGTC_249 wiskostatin 11.211 µM -0.780948760858064 0.215095267747684 no 2669 0.217416315827481 847 2775510 A n-wasp and actin depolymerizer. SGTC_1362 1611-0397 101 µM -0.782468542299855 0.21464791666898 no 2670 0.216969632887416 865 27816 SGTC_3261 9137475 49.47 µM -0.782834453598829 0.214540290680578 no 2671 0.216862166219616 800 17027690 SGTC_2346 9031566 143.75 µM -0.784139159725781 0.214156791139905 no 2672 0.216479229881777 872 4771086 SGTC_1170 0310-0127 64.8 µM -0.785773292482489 0.213677024518047 no 2673 0.216000157927316 883 774975 SGTC_73 0327-0325 16.231 µM -0.787817807266155 0.213077656028637 no 2674 0.215401641751127 826 53298 SGTC_2154 5570129 200 µM -0.788845413113584 0.212776774569771 no 2675 0.215101181628453 896 673366 SGTC_12 0849-0099 9.267 µM -0.791005711188121 0.212145051927014 no 2676 0.214470329376906 867 6071388 SGTC_1934 st074720 32.6 µM -0.792157103051648 0.211808805951976 no 2677 0.214134538797608 863 17250992 SGTC_2361 9034121 116 µM -0.793934156245347 0.211290457882984 no 2678 0.213616881987017 903 6496917 SGTC_2822 7994718 71.43 µM -0.794718371776418 0.211061946850148 no 2679 0.213388671533458 903 1018011 SGTC_113 0099-0221 2.5 µM -0.796197763281987 0.210631264450982 no 2680 0.21295854871078 858 89219 SGTC_2729 fluphenazine 10.66 µM -0.796321082424252 0.210595386918122 no 2681 0.212922717383303 865 3372 An atypical antipsychotic. SGTC_2243 6634756 200 µM -0.796379750779887 0.210578319652044 no 2682 0.212905672075411 852 885676 SGTC_384 k007-0144 5.16 µM -0.799580884929338 0.209648305702413 no 2683 0.211976833032313 894 6824886 SGTC_831 k061-1017 217 µM -0.800561451146991 0.209363909345561 no 2684 0.211692787459384 889 1240153 SGTC_1378 2093-0007 380 nM -0.801548680018716 0.209077810080213 no 2685 0.211407037048098 889 3618014 SGTC_2178 5812956 200 µM -0.804095004152224 0.208340948009668 no 2686 0.21067105480104 866 5403383 SGTC_1026 k007-1105 30.6 µM -0.804239369036088 0.208299217253167 no 2687 0.210629373065141 863 7066794 SGTC_2619 obliquin 87.91 µM -0.80755001551644 0.207343580918799 no 2688 0.209674835555787 866 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1374 2889-5571 141 µM -0.808670579637855 0.207020712021287 no 2689 0.209352327588906 859 2853281 SGTC_2070 5230947 200 µM -0.809074553239179 0.20690438782688 no 2690 0.209236132151035 889 2835538 SGTC_2561 acetosyringone 100 µM -0.810752441920107 0.20642165398013 no 2691 0.208753925367201 888 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1087 pterostilbene 9.05 µM -0.811099644841656 0.206321846004823 no 2692 0.208654224902444 889 5281727 Similar to reservatol, lowers cholesterol. SGTC_1127 asiatic acid 681.4 nM -0.81448494750376 0.205350196723291 no 2693 0.20768359597474 893 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1986 st071812 45 µM -0.815206152974509 0.205143548133345 no 2694 0.207477158227446 880 11838594 SGTC_1092 toremifene 6.32 µM -0.815596130587102 0.205031858486622 no 2695 0.207365581634477 882 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_297 0986-0032 24 µM -0.817558427847416 0.204470405013341 no 2696 0.20680468685765 865 2847425 SGTC_1049 3226-0134 66 µM -0.819122604434609 0.204023518132427 no 2697 0.206358233177492 873 5702385 SGTC_1615 st002656 86.5 µM -0.81977051363977 0.203838580365452 no 2698 0.20617347169664 872 1584458 SGTC_180 1486-1293 102.781 µM -0.820005709421311 0.203771471329378 no 2699 0.206106426196963 871 4140536 SGTC_1319 1306-0155 43.7 µM -0.82066246741442 0.203584146580575 no 2700 0.205919277578602 885 3122360 SGTC_2922 7999257 32.47 µM -0.821174433533491 0.203438191561557 no 2701 0.205773458544386 898 2988377 SGTC_773 4358-1457 44.6 µM -0.82132413436546 0.20339552555951 no 2702 0.205730832087154 905 1186886 SGTC_2365 9042475 200 µM -0.821848829208123 0.2032460252499 no 2703 0.205581469603003 875 6464479 SGTC_2100 5377183 190 µM -0.825203279478947 0.202291799015659 no 2704 0.20462809594095 858 2844202 SGTC_1713 st033146 12.748 µM -0.825614905634488 0.202174890337853 no 2705 0.204511288482206 879 674619 SGTC_1819 st053448 58.6 µM -0.826972595490433 0.201789570474891 no 2706 0.204126297211554 917 2857616 SGTC_2319 6033012 152.6 µM -0.829241296474071 0.201146682854927 no 2707 0.203483940653958 889 847246 SGTC_2515 chrysin 20.77 µM -0.829876481162921 0.200966909262966 no 2708 0.203304311711625 873 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2688 kanamycin b 96.69 µM -0.83001021311877 0.200929071969611 no 2709 0.203266504647985 863 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2702 st077768 96.8 µM -0.830186449743332 0.200879215196225 no 2710 0.203216687592935 856 6484119 SGTC_3227 9130768 49.47 µM -0.830310960637728 0.200843995940561 no 2711 0.203181496316349 902 17720899 SGTC_3291 9121177 71.43 µM -0.830714773850756 0.200729798496873 no 2712 0.203067389147958 891 17015612 SGTC_74 000s-0487 160.283 µM -0.832301417877589 0.200281476793734 no 2713 0.202619415249953 869 677548 SGTC_2678 equilin 100 µM -0.832756574310261 0.200152979052418 no 2714 0.202491015253015 841 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_800 3448-7362 155 µM -0.833606621852295 0.199913130132145 no 2715 0.202251346457962 889 15991913 SGTC_1080 nisoldipine 24.4 µM -0.83408588156958 0.199777978716988 no 2716 0.202116295207982 879 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2425 5628681 7.85 µM -0.834196041315406 0.19974692139878 no 2717 0.202085260771507 884 5714958 SGTC_376 3970-0862 59.1 µM -0.835112371531727 0.199488693161539 no 2718 0.201827220817891 898 3135186 SGTC_1521 st012942 49.4 µM -0.835998954380477 0.199239039302021 no 2719 0.201577745645418 858 24207259 SGTC_1414 3917-0015 5.4 µM -0.836163907814093 0.199192610649955 no 2720 0.201531349861081 871 6618702 SGTC_2580 diallyl disulphide 81.36 µM -0.836817857870412 0.199008610602086 no 2721 0.201347478949305 882 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2610 ononetin 44.17 µM -0.838396145020366 0.198564954557711 no 2722 0.200904126900477 908 259632 SGTC_1705 st027868 56.3335 µM -0.838558508506957 0.198519348097649 no 2723 0.200858551098425 877 292948 SGTC_940 3232-1287 54.8 µM -0.838980495646166 0.198400845218391 no 2724 0.20074012736382 878 1585493 YIL048W NEO1 SGTC_1921 5740136 50 µM -0.839695887094782 0.198200045770996 no 2725 0.200539460320388 874 1774243 SGTC_893 0958-0369 48.9 µM -0.840773060592171 0.197897931166338 no 2726 0.200237540881102 886 6819948 SGTC_2682 pyrogallin 40.03 µM -0.84117750121441 0.1977845696682 no 2727 0.200124251358832 868 822798 An ATP competetive kinase inhibitor. SGTC_997 3996-0078 137 µM -0.841901043825074 0.197581864325746 no 2728 0.199921673008618 874 735687 SGTC_529 4076-0302 30.3 µM -0.842227587221712 0.197490422134413 no 2729 0.199830287386 896 5816522 SGTC_2956 9076196 2.52 µM -0.842447118309957 0.197428961065932 no 2730 0.199768864087789 901 16423868 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.843619001428786 0.197101070268713 no 2731 0.199441171375192 867 17037758 SGTC_114 0364-0001 490.298 µM -0.843793929027065 0.197052154122583 no 2732 0.199392284286295 884 4003655 SGTC_187 1488-2104 32.728 µM -0.844248937499652 0.196924951548803 no 2733 0.199265156672592 872 2852859 SGTC_3212 9128307 49.47 µM -0.844957910055804 0.196726849650016 no 2734 0.199067169784445 890 27243542 SGTC_2916 7875993 68.79 µM -0.846232467473845 0.196371015077862 no 2735 0.198711536496429 874 1299250 SGTC_1848 st056003 16.4 µM -0.846499581939418 0.196296490777541 no 2736 0.198637053488446 866 146492 SGTC_2973 9094665 17.96 µM -0.847245454911372 0.196088484794308 no 2737 0.198429161172087 872 25237061 YIL048W NEO1 SGTC_1838 st055369 84.5 µM -0.84758861600013 0.195992830361265 no 2738 0.198333558226337 875 676036 SGTC_2520 obtusaquinone 4.71 µM -0.851653040839631 0.194862046673987 no 2739 0.197203345643548 884 5967872 SGTC_2774 tamoxifen 10.92 µM -0.857038604530687 0.193369828973822 no 2740 0.19571177493556 882 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1072 oxiconazole 14.9 nM -0.857511785124164 0.193239055404075 no 2741 0.195581052246179 864 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2424 5537928 59.2 µM -0.858530931001998 0.192957576050664 no 2742 0.195299679212556 880 5382802 SGTC_2119 5528445 120.635 µM -0.859576237397335 0.192669131661626 no 2743 0.195011339239106 907 791935 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.863520422476962 0.191583138541598 no 2744 0.193925697909191 875 6708739 YPR165W RHO1 SGTC_564 3555-0129 330 µM -0.864067845145658 0.191432707898679 no 2745 0.193775310826999 870 563260 SGTC_551 k048-0028 34.9 µM -0.866445790949698 0.190780093656316 no 2746 0.193122870936301 894 6836383 SGTC_1959 st077091 55.8 µM -0.8676878136147 0.190439770733082 no 2747 0.192782629476258 885 821356 YKL052C ASK1 SGTC_2603 homopterocarpin 100 µM -0.868912793943462 0.190104482943744 no 2748 0.192447415585708 899 101795 A weak amylase inhibitor. SGTC_3350 9150499 3.57 µM -0.8693407096415 0.189987444235153 no 2749 0.192330401184021 901 4910996 YPR165W RHO1 SGTC_2477 5967686 25.23 µM -0.87166997575848 0.189351146480874 no 2750 0.19169422206212 907 776118 SGTC_1827 berberine 7.24 µM -0.874496375103279 0.188580808167736 no 2751 0.190923996710642 872 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_859 0439-0102 54.6 µM -0.87486494490669 0.188480496664172 no 2752 0.19082369743666 889 610143 SGTC_975 1335-0046 28.5 µM -0.879972297573099 0.187093847490087 no 2753 0.189437158457552 906 16486740 SGTC_696 1560-0013 611 µM -0.880291042663243 0.187007517715968 no 2754 0.189350831900488 884 1650269 SGTC_1818 st052136 56.3 µM -0.880522306342829 0.186944897070611 no 2755 0.189288213320458 872 674169 SGTC_1926 methyl fluorone black 53.6 µM -0.880604081138842 0.186922757526844 no 2756 0.189266074452906 842 72721 Reacts with homocysteine. SGTC_334 1502-1024 68.5 µM -0.881221625887434 0.186755617095707 no 2757 0.189098938216162 895 3296216 SGTC_2686 alizarin 95.37 µM -0.881662760597191 0.186636279259422 no 2758 0.188979602389889 865 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1044 1222-0021 1.78 µM -0.882033528803636 0.186536013827483 no 2759 0.188879338011899 872 4306703 SGTC_2320 7373003 200 µM -0.883705643636683 0.186084244763041 no 2760 0.18842756649461 889 5415828 SGTC_2258 7960471 200 µM -0.884304717220013 0.185922553271822 no 2761 0.188265871256342 902 2974708 SGTC_683 panaxydol 45 µM -0.884329831081825 0.185915776879535 no 2762 0.188259094673948 877 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2525 harmine 47.85 µM -0.885893127213329 0.185494259260206 no 2763 0.187837559992323 871 5280953 A monoamine oxidase inhibitor SGTC_506 n9-isopropylolomoucine 153 µM -0.886939125714372 0.185212554102448 no 2764 0.187555837675417 898 6610355 SGTC_2212 7123476 200 µM -0.887420217277081 0.185083077225249 no 2765 0.187426351361563 884 1085715 SGTC_3351 9150312 21.596 µM -0.887463038265542 0.185071555475596 no 2766 0.187414828724826 899 4904905 SGTC_310 1273-0058 1.06 µM -0.890183982909292 0.184340350735654 no 2767 0.186683551827876 850 2734232 SGTC_46 0329-0187a 2.197 µM -0.891476746556631 0.183993574605072 no 2768 0.186336730531553 878 46494817 SGTC_763 3453-1109 128 µM -0.892730387998906 0.183657680977022 no 2769 0.186000786418759 885 1560353 SGTC_1596 piperlongumine 63 µM -0.892907391928935 0.183610286341345 no 2770 0.185953384125085 895 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_679 0422-0091 41.4 µM -0.894466864954592 0.183193050728833 no 2771 0.185536075379998 915 627384 YHR062C RPP1 SGTC_829 1635-0120 117 µM -0.895106171425233 0.183022175893864 no 2772 0.185365167626794 886 285054 SGTC_631 k072-0230 41.5 µM -0.898453672942512 0.182129074924585 no 2773 0.184471866446672 925 5773147 SGTC_1497 4476-2978 41.3 µM -0.899831323426523 0.181762315537482 no 2774 0.184105011101695 888 1528379 SGTC_1697 st025554 27.742 µM -0.900150588114983 0.181677386586574 no 2775 0.184020058785862 890 1269519 SGTC_1139 k015-0024 46.9 µM -0.901666369105929 0.18127450614579 no 2776 0.183617061633413 914 2766652 SGTC_2680 butyl paraben 22.24 µM -0.902148616399595 0.181146446722401 no 2777 0.183488963076679 929 7184 An antifungal and steroid mimetic. SGTC_3189 9110682 49.47 µM -0.905336658463907 0.180301297265107 no 2778 0.182643530648116 925 17122418 SGTC_3290 9121031 71.43 µM -0.905719845842311 0.180199881190001 no 2779 0.182542077726325 899 17014854 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.905898052605488 0.180152728395837 no 2780 0.182494907589057 895 2333 A French combination drug. SGTC_1142 3253-1408 9.78 µM -0.90614675059965 0.180086936852647 no 2781 0.182429091622896 909 256655 SGTC_2205 7238770 200 µM -0.906960381558386 0.179871801142917 no 2782 0.182213874224336 897 279867 SGTC_2062 5245942 200 µM -0.90772878178481 0.179668773364716 no 2783 0.182010766785767 919 1376160 SGTC_848 0368-0089 85.6 µM -0.908021661746804 0.179591426130454 no 2784 0.181933388546391 898 762535 SGTC_223 busulfan 5 mM -0.91016640973321 0.17902565338113 no 2785 0.18136737795755 894 2478 A DNA alkylator. SGTC_275 trichlorophene 5.69 µM -0.910233059108563 0.179008089627215 no 2786 0.181349806508653 884 62616 SGTC_1654 st012436 41.8 µM -0.910472716360589 0.178944942990779 no 2787 0.181286632051383 896 4323132 SGTC_3265 9137266 49.47 µM -0.911291721654121 0.17872925134353 no 2788 0.181070843542859 870 17224265 SGTC_1342 1486-1464 234 µM -0.91157807047954 0.178653877706519 no 2789 0.180995435388417 896 3253938 SGTC_507 nimesulide 162 µM -0.913007468218527 0.178277926543745 no 2790 0.18061930687462 901 4495 A COX2 inhibitor. SGTC_413 propylparaben 100 µM -0.914001145937449 0.178016869689974 no 2791 0.180358121780694 904 7175 A pharmaceutical preservative. SGTC_2972 9093619 59.92 µM -0.914282966851143 0.177942874207222 no 2792 0.180284089188744 892 25236256 SGTC_83 0170-0301 39.027 µM -0.914437175869792 0.177902392979597 no 2793 0.180243587517332 902 3089716 SGTC_3268 9137683 49.47 µM -0.916230516065413 0.177432051947841 no 2794 0.179773001571582 957 1953228 SGTC_1573 oleylamine 1.06 µM -0.917879647288422 0.177000226270215 no 2795 0.179340939036855 913 5356789 An amine of the fatty acid oleic acid. SGTC_279 1273-0055 2.93 µM -0.91975142223853 0.176510906560242 no 2796 0.17885133700489 935 2847562 SGTC_1783 st039459 87.517 µM -0.921136846180807 0.176149280370367 no 2797 0.178489492628554 911 729761 SGTC_25 0118-0223 35.662 µM -0.921694415373298 0.176003874959618 no 2798 0.178343997196654 898 5333628 SGTC_2587 piperic acid 92.2 µM -0.923142813356463 0.175626510443866 no 2799 0.177966392909036 890 5370536 SGTC_2312 7706453 155.7 µM -0.924913889414707 0.175165772926946 no 2800 0.177505350591457 907 976098 SGTC_2971 9092186 9.93 µM -0.925560862382719 0.174997657151983 no 2801 0.177337120291032 898 25236400 SGTC_1610 st001799 48.1 µM -0.929025909130434 0.174099008800089 no 2802 0.176437829639139 915 621897 SGTC_2274 7947094 46.08 µM -0.931148128319897 0.17355006942235 no 2803 0.175888472850903 902 2971028 SGTC_2733 amorolfine 100 µM -0.931898350597615 0.17335627854672 no 2804 0.175694530059911 955 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1656 st012921 11 µM -0.933514619576478 0.172939246344559 no 2805 0.175277162850869 885 6732821 SGTC_2148 5546263 113.568 µM -0.934579080078284 0.172664942035698 no 2806 0.175002632154644 931 792097 SGTC_713 1488-1073 324 µM -0.934609358171982 0.17265714363402 no 2807 0.174994827246692 926 3312542 SGTC_1590 st077108 57.8 µM -0.935985745579947 0.17230287952183 no 2808 0.174640263473135 893 5489485 SGTC_1228 0124-0032 52.5 µM -0.936829964358125 0.172085818279169 no 2809 0.174423014659225 903 X1228 SGTC_1835 st008666 49.2 µM -0.93746722908564 0.171922083663939 no 2810 0.174259136556956 898 690455 SGTC_2490 carminic acid 95.39 µM -0.937936474441184 0.17180158245355 no 2811 0.174138528648015 900 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3348 9149464 3.537 µM -0.938035599618235 0.171776134221206 no 2812 0.174113057763146 904 1951442 SGTC_16 erodoxin 22.806 µM -0.939399383965886 0.171426256712515 no 2813 0.173762864593364 904 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2158 5657123 3.6195 µM -0.939718636318372 0.17134441867952 no 2814 0.173680951588877 943 2858827 SGTC_511 blebbistatin 171 µM -0.940442595376754 0.171158929557309 no 2815 0.173495290942829 925 3476986 A myosin inhibitor. SGTC_1766 st045414 44.774 µM -0.942427037350837 0.170651144584715 no 2816 0.172987025049028 902 253960 SGTC_2122 5258151 111.688 µM -0.942701817514225 0.170580909100307 no 2817 0.172916721731507 923 2173356 SGTC_1500 4488-1866 171 µM -0.94291425109073 0.170526622470416 no 2818 0.172862382452802 923 2900003 SGTC_1764 st044502 93.5 µM -0.94475789594864 0.170055950405705 no 2819 0.172391245898249 915 8407 SGTC_979 1426-2828 121 µM -0.949747069336304 0.168786422727256 no 2820 0.171120393354434 926 747872 SGTC_936 3005-4620 401 µM -0.949831785224564 0.168764918933224 no 2821 0.171098866210325 906 777207 SGTC_2808 7946468 45.46 µM -0.952262387994799 0.168148698654047 no 2822 0.170481963874883 929 2970879 SGTC_495 decylubiquinone 155 µM -0.953507960572427 0.167833475731326 no 2823 0.170166382368793 932 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2700 st077718 96.8 µM -0.954668004538256 0.167540240332684 no 2824 0.169872807496719 919 904970 SGTC_3263 9137018 49.47 µM -0.956780540644665 0.167007082734061 no 2825 0.169339018054117 908 43844957 SGTC_1468 k284-1086 134 µM -0.95760757138335 0.166798656733729 no 2826 0.169130339907384 917 15996457 SGTC_247 mechlorethamine 29.705 µM -0.958696776641783 0.166524414399454 no 2827 0.168855761390229 889 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3097 9117246 49.47 µM -0.959540322686112 0.166312224756725 no 2828 0.168643308184455 907 16423892 SGTC_717 1532-0246 73.2 µM -0.959561343176249 0.166306939391918 no 2829 0.168638016216191 915 9561992 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.960322807854864 0.166115550837923 no 2830 0.168446387283846 903 688664 SGTC_886 0866-0150 153 µM -0.960470613939731 0.166078417361437 no 2831 0.16840920688451 921 271463 SGTC_1098 clofazimine 15.1 µM -0.961353528388364 0.165856713558721 no 2832 0.168187221006164 929 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2364 9055074 200 µM -0.961825840380119 0.165738192463402 no 2833 0.168068547761615 930 6470630 SGTC_774 k060-0086 136 µM -0.962033993631156 0.165685976260997 no 2834 0.16801626422802 930 5911235 SGTC_1141 3253-0389 52.6 µM -0.965016411603183 0.164938991222008 no 2835 0.167268295864205 922 5402031 SGTC_855 0428-0020 25 µM -0.967078488436923 0.164423794706056 no 2836 0.166752399168787 902 6812414 SGTC_1998 st075797 76.8 µM -0.967363621473058 0.164352638250141 no 2837 0.166681144592419 901 24208315 SGTC_1138 3761-0006 1.03 µM -0.970437633368334 0.163586770437302 no 2838 0.165914198877114 923 12061087 SGTC_534 k292-0788 63.4 µM -0.973195921034552 0.162901538801826 no 2839 0.165227968855265 939 4146317 SGTC_3269 9137823 49.47 µM -0.974102060565877 0.162676837614022 no 2840 0.165002933260501 881 17682936 SGTC_166 k072-0058 166.424 µM -0.974650843836793 0.162540850407897 no 2841 0.164866741986547 921 5846229 SGTC_178 4092-0806 87.505 µM -0.974769945764247 0.162511347001042 no 2842 0.164837194137538 902 2169044 SGTC_2558 carylophyllene oxide 100 µM -0.975100960452056 0.162429367797198 no 2843 0.164755091130186 940 6708694 An oxygenated terpenoid and antifungal agent. SGTC_65 0798-0905 34.986 µM -0.975702579482096 0.16228043955855 no 2844 0.164605936796839 962 3602145 SGTC_3262 9137218 49.47 µM -0.975755991205597 0.162267222010695 no 2845 0.164592699108868 884 17650664 SGTC_3352 9151559 45.5865 µM -0.977972380299407 0.161719360626856 no 2846 0.164043992298927 908 17159339 SGTC_1097 itavastatin 7.23 µM -0.978410295784736 0.161611256638005 no 2847 0.163935719034742 912 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2400 5203494 178.7 µM -0.984622954194151 0.160082673415252 no 2848 0.162404655132153 917 6777674 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.985000677098027 0.159990043050231 no 2849 0.162311869186671 943 689007 SGTC_2276 7947513 42.08 µM -0.985063523161148 0.159974634482871 no 2850 0.162296434680838 940 2105100 SGTC_314 1671-0008 2.74 µM -0.985490236837465 0.159870038696661 no 2851 0.162191662378898 923 3913060 SGTC_1368 1852-0141 284 µM -0.986789298569916 0.159551888956741 no 2852 0.161872970996012 933 2838987 SGTC_873 0591-4978 488 µM -0.987832595378174 0.159296678178106 no 2853 0.161617320567207 915 3305145 SGTC_3129 9127257 49.47 µM -0.990952245254074 0.158535146548269 no 2854 0.160854449654735 933 837894 SGTC_3241 9133421 49.47 µM -0.991174711062025 0.158480932207849 no 2855 0.160800138399969 961 17018221 SGTC_356 1634-0012 32.5 µM -0.99157548297329 0.158383295821905 no 2856 0.160702326950461 932 735457 SGTC_446 go6976 132 µM -0.991768644287414 0.158336251798072 no 2857 0.160655198333743 944 3501 A protein kinase C inhibitor. SGTC_229 benomyl 22.8748 µM -0.993056732239404 0.158022775167946 no 2858 0.160341153994451 926 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3037 9091026 49.47 µM -0.994477434744277 0.157677497522132 no 2859 0.159995242928347 930 25236398 YIL048W NEO1 SGTC_1718 roemerine 11.9335 µM -0.995412073559374 0.157450619887522 no 2860 0.159767944436635 878 235224 An aporphine alkaloid with mutagenic activity. SGTC_502 l-744,832 89.3 µM -0.995748148006033 0.157369092420648 no 2861 0.159686264835456 940 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.997936341345199 0.156838942669268 no 2862 0.159155114149748 924 6728940 SGTC_2969 9091408 28.7 µM -0.999003022813225 0.156580936441016 no 2863 0.158896613478686 918 4286311 SGTC_450 aminopyrene 156 nM -1.00045196851073 0.15623091692271 no 2864 0.158545915497804 920 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2614 arthonioic acid 13.39 µM -1.00504860560623 0.155123928563524 no 2865 0.157436722887573 953 6710684 SGTC_1868 st057644 42.7 µM -1.00668356189019 0.154731440654314 no 2866 0.157043431994414 949 688665 SGTC_3147 9097027 49.47 µM -1.00753367678227 0.154527621418384 no 2867 0.156839191317107 943 25236841 SGTC_1704 st028805 70.8 µM -1.00872007708787 0.154243472871712 no 2868 0.15655445014028 935 2876101 SGTC_601 0986-0029 62.9 µM -1.00944416932887 0.1540702192329 no 2869 0.156380832243239 908 24747981 SGTC_221 trifluoperazine 10.304 µM -1.01660613813524 0.152363510471626 no 2870 0.154670416513258 944 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1387 3342-1166 1.8 µM -1.01721298148439 0.15221947763624 no 2871 0.154526060924111 915 3418228 SGTC_21 0849-0113 22.993 µM -1.01761858861665 0.152123258161897 no 2872 0.154429624973494 930 1560156 SGTC_1719 st032227 49.2 µM -1.01767805360381 0.15210915507513 no 2873 0.154415490099138 924 3125804 SGTC_1236 0330-0013 258 µM -1.02222790821406 0.15103265782377 no 2874 0.153336522412209 955 4617066 SGTC_1530 rhein 70.4 µM -1.02282120101432 0.150892659099773 no 2875 0.153196195993185 926 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_813 k007-0158 173 µM -1.02375267965936 0.150673033314709 no 2876 0.152976053143631 927 6523916 SGTC_226 1,3-diallylurea 8.28947 mM -1.02423882146062 0.150558494470075 no 2877 0.152861243191383 927 74537 YKL182W FAS1 SGTC_851 0394-0702 453 µM -1.02546788006908 0.150269177277307 no 2878 0.152571236768378 941 762646 SGTC_1006 4099-6547 255 µM -1.02549349723071 0.150263151008606 no 2879 0.152565196075934 949 3146833 SGTC_2032 5185112 25.99 µM -1.02684389630343 0.149945706533966 no 2880 0.152246987899687 914 5718189 SGTC_1171 0368-0077 21.4 µM -1.02745561448816 0.149802054428134 no 2881 0.15210298767619 931 3239779 SGTC_2185 6113692 200 µM -1.02785370673345 0.149708618238449 no 2882 0.152009324214154 942 874150 SGTC_2197 6588183 93.1375 µM -1.02862259492521 0.149528262661417 no 2883 0.151828528058382 918 884136 SGTC_1075 aripiprazole 15.2 µM -1.02966055126911 0.149285022743275 no 2884 0.151584690005886 945 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1130 3454-2858 15.9 µM -1.03123735939197 0.148916011379105 no 2885 0.151214762574232 941 715628 YIL048W NEO1 SGTC_702 1488-0190 94 µM -1.03586483593596 0.147836590956899 no 2886 0.15013260230937 921 949357 SGTC_2924 9010168 62.78 µM -1.03856779085212 0.147208520386138 no 2887 0.149502896011744 950 2993929 SGTC_746 1095-0025 46.6 µM -1.03902514294891 0.147102425219888 no 2888 0.149396521503461 939 6749286 SGTC_105 0111-0055 734.78 µM -1.03973144749177 0.146938679558517 no 2889 0.149232342986069 955 5179370 SGTC_3140 9094243 49.47 µM -1.04167099082109 0.146489655744152 no 2890 0.148782121436888 952 19291112 SGTC_116 0155-0182 31.788 µM -1.04315968046181 0.146145634532834 no 2891 0.148437171883231 846 771486 SGTC_444 curcumin 90.4 µM -1.04426571348348 0.145890393059716 no 2892 0.148181235627371 929 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_558 k064-0027 21.3 µM -1.04663556723729 0.145344506262772 no 2893 0.14763384564678 909 5088526 SGTC_3264 9137442 49.47 µM -1.04682845585829 0.145300135653141 no 2894 0.147589351820512 934 17015726 SGTC_18 0111-0177 500 nM -1.04896938826696 0.144808264014274 no 2895 0.147096103801743 949 721752 SGTC_3223 9129970 49.47 µM -1.04944478347913 0.144699195958711 no 2896 0.146986727942898 953 17248386 SGTC_86 0417-1630 471.922 µM -1.04996870754053 0.144579058226759 no 2897 0.146866250071647 930 3634867 SGTC_1 0258-0098 57.368 µM -1.05068345487928 0.144415272404489 no 2898 0.146701998678626 898 6790032 YDR047W HEM12 SGTC_2732 terfenadine 20 µM -1.05198216197932 0.144117991121612 no 2899 0.146403866885578 962 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2098 5376439 882.5 nM -1.05449558160902 0.143543828148239 no 2900 0.145828041225037 929 2844116 SGTC_1949 st076024 69.1 µM -1.05668262616853 0.143045479927313 no 2901 0.145328228385893 948 2921930 SGTC_1956 st077085 54 µM -1.0574995109359 0.142859641690524 no 2902 0.145141838852798 947 24208685 SGTC_2914 7968218 45.32 µM -1.05854182977502 0.142622755083263 no 2903 0.144904245463116 926 2977111 SGTC_2321 7390090 138.78 µM -1.06120637949173 0.14201839384179 no 2904 0.144298060411636 967 649046 SGTC_2423 st077119 87.2 µM -1.0640439726306 0.141376692455343 no 2905 0.143654389966959 926 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2391 6285546 200 µM -1.06507581090911 0.141143837590645 no 2906 0.14342081225903 945 846083 SGTC_1780 st038448 24.544 µM -1.06664033641258 0.140791267578658 no 2907 0.143067139304658 953 728868 YDL195W SEC31 SGTC_553 k007-0256 45.7 µM -1.06686578525412 0.14074051138037 no 2908 0.143016223484336 946 6287000 SGTC_2390 9097792 176.6 µM -1.0673880120672 0.140622988068853 no 2909 0.142898329761961 927 4497149 SGTC_3134 9127454 49.47 µM -1.07331933204231 0.139292862388225 no 2910 0.141563932141127 964 24262820 SGTC_803 4488-1585 147 µM -1.07390079278754 0.139162929425425 no 2911 0.141433573992807 935 747204 SGTC_2112 5488546 200 µM -1.07433115117363 0.139066814864934 no 2912 0.141337144005497 989 600757 SGTC_2113 5491891 107.031 µM -1.07456893026756 0.139013729595932 no 2913 0.141283884191499 942 789979 SGTC_3146 9095609 49.47 µM -1.074681272839 0.138988653402805 no 2914 0.141258725465639 959 17173999 SGTC_2362 9071156 126 µM -1.0806772476879 0.137654747928341 no 2915 0.139920353666164 963 653133 SGTC_2929 9013348 24.6 µM -1.08341165048143 0.137049344250717 no 2916 0.139312873358634 947 2995952 SGTC_1937 st074714 47.2 µM -1.08547258931003 0.136594251231934 no 2917 0.138856198786043 951 17250970 SGTC_205 1486-1330 71.903 µM -1.08599350224275 0.136479387920433 no 2918 0.138740933505683 954 4118834 SGTC_887 0885-0007 9.62 µM -1.08657849052769 0.136350474522683 no 2919 0.138611567627119 960 5719458 SGTC_2728 chlorpromazine 9.18 µM -1.08697767915441 0.13626255348073 no 2920 0.138523337170284 983 2726 A thorazine and dopamine antagonist. SGTC_2897 9048598 12.99 µM -1.08704285282058 0.136248202706683 no 2921 0.138508935829648 964 6467404 SGTC_939 1165-0479 45.3 µM -1.08917347646587 0.135779624150788 no 2922 0.138038696479987 932 1377347 SGTC_319 1348-1596 45.5 µM -1.0951745819966 0.134465764921554 no 2923 0.136720079548024 952 5380505 SGTC_641 4092-0595 30 µM -1.10092795728373 0.13321436316159 no 2924 0.135464006602268 972 786260 SGTC_869 0564-0080 44.1 µM -1.10194019654735 0.132995025336062 no 2925 0.135243835889757 940 6843321 SGTC_467 ro 31-8220 72.8 µM -1.1059026630563 0.132138807440385 no 2926 0.134384326014412 954 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3158 9100007 49.47 µM -1.10645564656763 0.132019620522975 no 2927 0.13426467569395 969 19297233 SGTC_2984 9022109 38.96 µM -1.11080025879627 0.131085786986518 no 2928 0.133327167529546 987 6459207 SGTC_2007 4011539 71.82 µM -1.11146640340146 0.130943009934106 no 2929 0.133183821771073 943 45595301 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.11234155130708 0.130755599861997 no 2930 0.132995662431652 936 5379071 SGTC_410 α-linolenic acid 100 µM -1.11434504306961 0.130327256971715 no 2931 0.132565595145148 955 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2242 6630449 61.2675 µM -1.11482067466977 0.130225710542393 no 2932 0.132463637488136 955 691249 YDR170C SEC7 SGTC_585 0kpi-0023 191 µM -1.11483044168733 0.13022362587677 no 2933 0.132461544370577 918 64601 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.1185860358942 0.129423745315738 no 2934 0.131658391747059 973 6708784 An antioxidant flavonoid SGTC_1863 st057641 20.1 µM -1.11915171256323 0.129303561021199 no 2935 0.131537710789357 978 3921635 SGTC_2961 9083290 32.55 µM -1.12079561438964 0.128954734914455 no 2936 0.13118743568803 952 17741490 SGTC_2872 9044037 25.97 µM -1.12263718172874 0.12856474105717 no 2937 0.130795808644558 957 6465195 SGTC_1752 st044819 83.042 µM -1.12574058795489 0.127909377584648 no 2938 0.130137669208263 956 441209 YML126C ERG13 SGTC_1186 1319-0216 26 µM -1.12764043704509 0.127509323336573 no 2939 0.129735900935049 955 4565136 SGTC_276 colchicine 750 µM -1.12920406474878 0.127180721106472 no 2940 0.129405879714154 946 2833 A microtubule depolymerizer. SGTC_2849 9019321 12.99 µM -1.13004628726712 0.127003969242722 no 2941 0.129228360436645 953 16489627 SGTC_2370 9071495 200 µM -1.13256416490823 0.126476578171781 no 2942 0.128698662240468 983 21791103 SGTC_588 3970-1144 52.9 µM -1.13498108962596 0.125971769540628 no 2943 0.128191620877347 934 1888707 SGTC_1025 k007-0731 70 µM -1.14075824448808 0.124770827519274 no 2944 0.126985270589757 957 6256118 SGTC_3247 9135149 49.47 µM -1.14596699741389 0.12369492250252 no 2945 0.125904403869407 960 8934436 YOR116C RPO31 SGTC_1397 3532-0190 20.1 µM -1.15857549061549 0.121117491791546 no 2946 0.12331463203189 942 5322280 SGTC_1866 st057638 64 µM -1.15913627358523 0.121003740515574 no 2947 0.123200321128269 938 688802 SGTC_1331 1472-0049 76.2 µM -1.16113921581764 0.120598070114182 no 2948 0.122792644522986 967 24051409 SGTC_2358 9037157 4 µM -1.1624218332702 0.120338795789026 no 2949 0.122532079444625 947 2388925 SGTC_1897 st060201 15 µM -1.16298569930086 0.120224937599184 no 2950 0.122417652322041 975 611878 SGTC_320 4092-0846 5.34 µM -1.16617018654767 0.119583337354538 no 2951 0.121772821952153 955 1359356 SGTC_1398 3558-0053 112 µM -1.16633846649485 0.119549500166939 no 2952 0.121738813270492 960 4532369 SGTC_2504 purpurogallin 52.29 µM -1.16661325687942 0.119494260725326 no 2953 0.121683293617332 960 5281571 An antioxidant. SGTC_546 peri-Naphthalide 147 µM -1.16670543395703 0.11947573496132 no 2954 0.121664673809777 942 223824 A penicillin ester. SGTC_2903 5923464 63.88 µM -1.16758399951488 0.119299262406829 no 2955 0.121487303691484 978 2876576 SGTC_3041 9091929 49.47 µM -1.16904289498108 0.119006628733243 no 2956 0.121193174751654 957 25236887 SGTC_807 1315-0151 48 µM -1.16921341229877 0.118972458496838 no 2957 0.121158829354577 977 4011080 SGTC_3198 9112019 49.47 µM -1.17257514192754 0.118300210477003 no 2958 0.120483111355163 997 45595555 SGTC_766 1391-0721 126 µM -1.17461251275017 0.117894104991745 no 2959 0.120074887479229 997 1020919 YIL115C NUP159 SGTC_3196 9111891 49.47 µM -1.17809092659606 0.117203040419858 no 2960 0.119380179451333 991 18891510 SGTC_953 1188-0045 9.7 µM -1.17979711244957 0.116865119498528 no 2961 0.119040459136138 967 6144426 SGTC_3000 9075062 71.4286 µM -1.1816105237475 0.11650671958727 no 2962 0.118680137951518 925 17057871 SGTC_1402 3909-7673 35.9 µM -1.18890912525562 0.115072119729377 no 2963 0.117237714436981 989 5328014 SGTC_491 tetrandrine 80.3 µM -1.19384608877992 0.114108868783514 no 2964 0.116269089629382 981 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_603 3794-0023 45.9 µM -1.19465424894721 0.113951737305772 no 2965 0.116111072251875 993 3802260 SGTC_2734 clemastine 41.6 µM -1.19523896176191 0.113838147107727 no 2966 0.11599684000952 1020 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3138 9097216 49.47 µM -1.1969899786492 0.113498465646673 no 2967 0.115655230402367 969 25237486 SGTC_261 5-fluorouridine 15.376 µM -1.19760758859157 0.113378827491328 no 2968 0.11553491021926 986 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2334 9017922 200 µM -1.19886198118932 0.113136114126895 no 2969 0.115290808518694 962 3163164 SGTC_1074 carmofur 3.8 µM -1.2019382281218 0.112542458849507 no 2970 0.114693730947719 974 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_352 k048-0007 5.11 µM -1.20267244038722 0.112401099792022 no 2971 0.114551551411984 977 6811911 SGTC_3301 9125354 19.7965 µM -1.20594458214554 0.111772651654931 no 2972 0.113919429550722 952 41905162 SGTC_945 3381-0768 11.3 µM -1.20613571701096 0.111736020104623 no 2973 0.113882582546203 975 1126236 YIL048W NEO1 SGTC_2428 5615643 7.78 µM -1.20754919460176 0.11146538958909 no 2974 0.113610355765491 969 2253075 SGTC_720 r052-1644 49.9 µM -1.20894664683756 0.111198288827333 no 2975 0.113341671753806 979 1422863 YOR257W CDC31 SGTC_559 1550-0661 158 µM -1.21058948791913 0.110884872310892 no 2976 0.113026387533306 978 5830875 SGTC_458 nppb 133 µM -1.21062622585754 0.110877870793777 no 2977 0.113019344170406 990 4549 A chloride channel blocker. SGTC_858 0438-0351 2.77 µM -1.21064451928097 0.110874384550856 no 2978 0.113015837089349 977 2799119 SGTC_1655 st012546 55.1 µM -1.21096862241871 0.110812632080321 no 2979 0.11295371528871 985 720985 YLR208W SEC13 SGTC_2505 galangin 7.89 µM -1.21194532665587 0.110626686344645 no 2980 0.112766654924974 982 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_992 3909-8734 162 µM -1.21257622687629 0.110506693998961 no 2981 0.11264594128851 995 4288319 SGTC_3154 9100113 49.47 µM -1.21500033571799 0.110046515250241 no 2982 0.112182981669352 974 25237525 SGTC_2213 7173844 200 µM -1.21741552595 0.109589398455146 no 2983 0.111723079380332 985 892728 SGTC_918 glabranin 770.725 nM -1.21992760183939 0.10911539257703 no 2984 0.111246160629871 990 124049 Also referred to as licorice root. SGTC_1036 k216-0215 33.5 µM -1.2207080011013 0.108968438723334 no 2985 0.111098298634672 902 622330 SGTC_2911 7942208 15.64 µM -1.22738233553864 0.107717430230206 no 2986 0.109839461237724 947 1243384 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.23204817420517 0.106849051881666 no 2987 0.108965544589488 962 6708514 SGTC_3062 9077494 49.47 µM -1.23280362954329 0.10670892745386 no 2988 0.108824518438436 868 16459633 SGTC_1605 st000082 49.1 µM -1.23512135176821 0.106279856136549 no 2989 0.108392672002627 953 1114022 SGTC_3220 9131269 49.47 µM -1.23620434866014 0.10607979264897 no 2990 0.108191307335221 987 17722206 SGTC_3122 9126309 49.47 µM -1.2372653086803 0.10588406404591 no 2991 0.107994301286973 1009 17591206 SGTC_500 h-89 112 µM -1.24445508581549 0.104564550432224 no 2992 0.106666059916378 987 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3305 9127027 53.8275 µM -1.24548520324738 0.104376476645205 no 2993 0.106476725614235 977 41905295 SGTC_3130 9127414 49.47 µM -1.2466323832175 0.104167318795244 no 2994 0.106266161065929 992 1494646 SGTC_1237 0330-0133 46.1 µM -1.24955807161774 0.103635273007696 no 2995 0.105730513777843 987 X1237 YHR072W ERG7 SGTC_1744 st037937 38.9 µM -1.24984071015524 0.103583978921482 no 2996 0.105678870707883 1010 1016152 SGTC_3148 9097893 49.47 µM -1.25089332398123 0.103393109492199 no 2997 0.105486699945908 948 17174100 SGTC_2035 5154463 94.595 µM -1.25236137835025 0.103127335161681 no 2998 0.105219106389389 992 2769623 SGTC_2095 5432005 200 µM -1.25466074797128 0.102712058497437 no 2999 0.104800970327509 992 783734 SGTC_2830 7992007 71.43 µM -1.25641243016542 0.102396513257542 no 3000 0.104483238621065 974 1952075 SGTC_1728 st035614 33.7865 µM -1.26112485061461 0.101551125692427 no 3001 0.103631934261952 972 15945546 SGTC_1822 st052468 42 µM -1.26458033918868 0.100934464210069 no 3002 0.103010902292364 978 2873678 SGTC_911 3456-4043 236 µM -1.26520294163462 0.10082364635082 no 3003 0.102899294124939 979 914281 SGTC_999 SEC7.066 22.7 µM -1.26887219258487 0.100172353126412 no 3004 0.102243325783595 996 740511 YDR170C SEC7 SGTC_1870 st057514 26.5 µM -1.26971846613658 0.100022576137742 no 3005 0.102092466301261 984 5393161 SGTC_2005 4024620 188 µM -1.27241273002768 0.0995468233314219 no 3006 0.101613256699832 993 236743 SGTC_3005 9076496 71.4286 µM -1.27357179802908 0.0993426647761138 no 3007 0.10140760615099 986 21368410 SGTC_2867 9039098 71.43 µM -1.27375537979331 0.0993103567351531 no 3008 0.101375061528455 974 6463460 SGTC_2731 amoxapine 43.43 µM -1.27615827224629 0.0988881865234379 no 3009 0.10094978796414 1035 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_11 0438-0307 1.3 µM -1.2795666704021 0.0982916108971283 no 3010 0.100348788984815 989 4011476 SGTC_2759 disulfiram 3.38 µM -1.28002878782213 0.0982109293416748 no 3011 0.100267505783164 961 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3303 9125618 40.5795 µM -1.28126042031536 0.0979961343242979 no 3012 0.100051105034862 966 22695467 SGTC_1298 1079-1278 263 µM -1.28130175269251 0.0979889319893216 no 3013 0.100043848757053 992 2840950 SGTC_1464 k208-0027 110 µM -1.28352997418368 0.0976012292515019 no 3014 0.0996532325987832 968 X1464 SGTC_333 3486-0131 40.1 µM -1.28532799824698 0.0972892003619606 no 3015 0.0993388451173888 969 6744690 SGTC_3221 9128209 49.47 µM -1.28614750892203 0.0971472256399004 no 3016 0.0991957931283396 987 16460723 SGTC_2265 7929201 200 µM -1.28640904833822 0.0971019477134445 no 3017 0.099150171105045 983 1265108 SGTC_2517 totarol 10 µM -1.28944424026098 0.0965776251271629 no 3018 0.0986218447776549 981 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_185 k048-0037 25.491 µM -1.2933964214479 0.0958980159499697 no 3019 0.0979369935898154 993 6827589 SGTC_1335 1486-0900 202 µM -1.29548686800646 0.0955399723243785 no 3020 0.097576164290824 986 X1335 SGTC_2279 7948423 32.93 µM -1.29707199370934 0.0952691346377196 no 3021 0.0973032083624654 971 1247112 SGTC_862 0452-0056 10.2 µM -1.29762948309565 0.0951740154045609 no 3022 0.0972073429291741 1008 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1180 1193-0155 285 µM -1.29869498568882 0.0949924132008266 no 3023 0.0970243127978934 1011 2921347 SGTC_301 4119-0100 24.5 µM -1.29943276993446 0.0948668163309982 no 3024 0.0968977258464977 996 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2521 angolensin 13.4 µM -1.30257920867706 0.0943325550680435 no 3025 0.0963592298862271 983 821428 A flavenoid. SGTC_2473 5854593 8.94 µM -1.30282325379895 0.0942912094355137 no 3026 0.0963175549727064 981 2872951 SGTC_586 0957-0265 8.15 µM -1.30345167468271 0.0941848051588939 no 3027 0.0962103022448558 959 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_692 k241-0027 77.8 µM -1.3076447078069 0.0934771068077997 no 3028 0.095496922706932 979 3600480 SGTC_3349 9149703 23.001 µM -1.30892758580739 0.0932613698293766 no 3029 0.095279440624944 1000 4910494 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.31028551150548 0.0930334133811872 no 3030 0.0950496334797575 1008 368090 SGTC_478 N-arachidonylglycine 10 µM -1.31742714691429 0.0918413150143889 no 3031 0.0938477431619974 1000 5283389 SGTC_1005 4092-0690 4.4 µM -1.31796251117784 0.0917524087465113 no 3032 0.0937580989150161 1005 1529343 SGTC_1168 k815-0004 80.5 µM -1.3191447401089 0.0915563055697564 no 3033 0.0935603641547007 1008 642433 SGTC_1738 st035555 74 µM -1.32964525885693 0.089828137286895 no 3034 0.0918175893923153 993 5331140 SGTC_977 1348-1378 135 µM -1.33600764330811 0.0887928840435087 no 3035 0.0907733875327915 984 X977 SGTC_1252 0493-0875 34.8 µM -1.34113772431328 0.0879646351871911 no 3036 0.0899378705714706 984 3960963 SGTC_1821 st053465 65.6 µM -1.34770014821214 0.0869135513642496 no 3037 0.0888774222016451 1009 675086 SGTC_2450 5739737 12.93 µM -1.35138112481614 0.0863281027826779 no 3038 0.0882866884901353 991 2262825 SGTC_3335 9143315 29.6265 µM -1.35456348882168 0.0858243383329145 no 3039 0.0877783363567942 986 4899691 SGTC_1296 1068-0102 11.9 µM -1.35458113611001 0.0858215509358346 no 3040 0.0877755234721299 997 767053 SGTC_1024 4507-0395 26 µM -1.35759023690847 0.0853472523216072 no 3041 0.0872968713074745 1008 4201836 SGTC_199 4063-0024 41.6 µM -1.35844890580005 0.085212268521919 no 3042 0.0871606424421924 1019 306215 SGTC_1328 1441-0025 69.2 µM -1.35875763827798 0.0851637745155558 no 3043 0.0871117004786099 992 4562601 SGTC_2725 haloperidol 53.21 µM -1.35983262151898 0.0849950833977194 no 3044 0.0869414483865354 996 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3193 9111931 49.47 µM -1.3598552856255 0.0849915295438863 no 3045 0.0869378616019583 1011 17087244 SGTC_2600 tangeritin 87.95 µM -1.3628282395456 0.084526319335736 no 3046 0.086468324459044 995 68077 A bioactive flavone. SGTC_1409 3909-8004 61.9 µM -1.36327513098989 0.0844565548749161 no 3047 0.0863979083374575 1006 2119279 SGTC_2030 5175110 200 µM -1.36559078799829 0.0840957481840303 no 3048 0.0860337197830906 1019 2831986 SGTC_2726 cimetidine 79.27 µM -1.36771745144908 0.0837654094185117 no 3049 0.0857002676039003 1001 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1002 4049-0206 172 µM -1.3711132809388 0.0832399508843393 no 3050 0.0851698227498267 992 4662749 SGTC_1662 st014054 52 µM -1.37129683845479 0.0832116186096874 no 3051 0.0851412204288609 1018 2838777 SGTC_958 1222-0007 33 µM -1.37706954569817 0.0823242912121342 no 3052 0.0842453736254288 999 7312461 SGTC_779 1360-0071 233 µM -1.38057650445023 0.0817887239871563 no 3053 0.0837046058425795 991 7566 SGTC_1862 st057513 3.81 µM -1.38256797230736 0.0814857671926356 no 3054 0.0833986875787836 1002 5393163 SGTC_2389 9091542 195.52 µM -1.38531242890152 0.0810696479963877 no 3055 0.0829784774524699 986 3626624 YOL127W RPL25 SGTC_726 3448-4391 34.2 µM -1.38609427736599 0.0809513968069413 no 3056 0.0828590587839976 1004 1356692 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.38733594799041 0.0807638671547204 no 3057 0.0826696731829512 1015 364106 SGTC_1484 3473-2379 286 µM -1.38849557419497 0.0805890250889438 no 3058 0.0824930957606476 1047 671917 SGTC_417 st075190 100 µM -1.38887744856784 0.0805315107897194 no 3059 0.0824350095645665 1012 222757 SGTC_3353 9151644 39.2805 µM -1.39189213599498 0.080078555247497 no 3060 0.0819775317841859 1011 4909158 SGTC_1864 st057645 30.4 µM -1.39910212699347 0.0790030716156203 no 3061 0.080891179995512 1006 688666 SGTC_2360 9040895 200 µM -1.4034474662127 0.0783602003334068 no 3062 0.0802417235321187 1001 4914414 SGTC_179 1273-0063 6.77 µM -1.40418528233416 0.0782514391654199 no 3063 0.0801318416578922 1025 3108139 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.40590498996695 0.0779983822233599 no 3064 0.079876169690882 986 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1481 3346-2004 36 µM -1.40623353457999 0.0779501072303767 no 3065 0.0798273946500771 1028 2770522 SGTC_3110 9122132 49.47 µM -1.40670891952103 0.0778802962640882 no 3066 0.0797568598858591 1021 918317 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.40932229422426 0.0774973655251935 no 3067 0.0793699447326415 987 688667 SGTC_24 0417-1663 219 µM -1.41186886238105 0.0771256008762397 no 3068 0.0789942887809756 1036 4329390 SGTC_61 0978-8327 98.565 µM -1.41305093772662 0.0769534950064079 no 3069 0.0788203737277483 990 6150059 YHR072W ERG7 SGTC_1679 SEC14.276 6.7 µM -1.41370921359535 0.0768577790677919 no 3070 0.0787236494955547 992 1005053 YMR079W SEC14 SGTC_2526 patulin 37.61 µM -1.41821115037344 0.0762056040548982 no 3071 0.0780645637272145 1017 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_662 k832-1615 104 µM -1.41831334083011 0.0761908492319221 no 3072 0.0780496517331034 1011 5878478 SGTC_3317 9138495 8.753 µM -1.42113121291365 0.0757848453921122 no 3073 0.0776393087189254 1010 17020139 SGTC_2630 antimycin a 100 µM -1.43005450236548 0.0745100312250976 no 3074 0.0763506885040649 1021 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1068 loratadine 26.9 µM -1.43021002289859 0.0744879590248563 no 3075 0.0763283748207424 1029 3957 A H1 histamine antagonist. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.43135318637185 0.0743258690881261 no 3076 0.076164508955464 981 4330530 SGTC_1259 0671-0132 43 µM -1.43406510568153 0.0739424216560847 no 3077 0.0757768422606864 1003 X1259 SGTC_1377 2944-0135 198 µM -1.43640256707599 0.0736131345954282 no 3078 0.0754439115571516 983 1894137 SGTC_2776 terbinafine 19.92 µM -1.43664118274286 0.0735795830674379 no 3079 0.0754099877145101 975 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2323 6148992 148.28 µM -1.43719547980065 0.0735016890000704 no 3080 0.0753312285155171 995 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_547 1120-0019 610 nM -1.43744763191048 0.0734662755287645 no 3081 0.0752954213739731 963 3676939 SGTC_145 3737-0113 38.366 µM -1.44155848686775 0.0728907658478775 no 3082 0.074713483324766 1004 6849351 SGTC_658 3253-0951 102 µM -1.44354664971668 0.0726136690464564 no 3083 0.074433270616118 1020 1184878 SGTC_2091 4-phenylthiadiazole 200 µM -1.44431676091849 0.0725065531510005 no 3084 0.0743249465841569 1019 270010 SGTC_3099 9120367 49.47 µM -1.44719353052533 0.0721074894308172 no 3085 0.0739213639939325 1024 24824940 SGTC_2572 astragaloside iv 100 µM -1.45313914621287 0.0712880556394554 no 3086 0.0730925620187985 1008 45006101 An anti-inflammatory agent. SGTC_2315 7733312 200 µM -1.45544089542129 0.0709727514119289 no 3087 0.0727736208637408 1009 726316 SGTC_2124 5246320 200 µM -1.45801388615444 0.0706215604160003 no 3088 0.072418357763835 1006 579342 SGTC_751 0833-0568 350 µM -1.45919993934535 0.0704601248148671 no 3089 0.0722550427562832 1031 6954252 SGTC_169 k015-0017 16.025 µM -1.45991597909933 0.0703628009245055 no 3090 0.0721565835354752 1041 1840002 SGTC_1446 4239-0190 62 µM -1.46292287712341 0.0699552324123012 no 3091 0.0717442416634227 1035 1340085 SGTC_520 3584-0023 682 µM -1.46420052259638 0.0697826054854565 no 3092 0.0715695837450788 1005 1340790 SGTC_670 4204-0025 119 µM -1.46661511332126 0.0694572576965792 no 3093 0.0712403931864366 1021 719039 SGTC_2033 5192550 145 µM -1.46800048984551 0.0692711168325097 no 3094 0.0710520449243507 999 182073 SGTC_3182 9108849 49.47 µM -1.469280775258 0.0690994380359046 no 3095 0.0708783245083054 1012 17133045 SGTC_1653 st012112 65 µM -1.46981621286322 0.0690277362923346 no 3096 0.0708057684516256 1017 720429 SGTC_1925 st057770 10.1 µM -1.4758275735894 0.0682266712949949 no 3097 0.0699950932563022 1007 5989122 SGTC_257 daunorubicin 18.5 µM -1.47628114325729 0.0681665215970077 no 3098 0.0699342170667054 988 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1865 st057639 52.2 µM -1.48901890512123 0.0664939781865626 no 3099 0.0682411952709341 1020 688818 SGTC_2414 st077232 92.9 µM -1.4902176742531 0.0663382228097891 no 3100 0.06808350531496 1009 729801 SGTC_3045 9092950 49.47 µM -1.49185273707011 0.0661262356985584 no 3101 0.0678688775689543 1021 44120432 SGTC_84 0443-0269 128.823 µM -1.49453569481398 0.0657795257150897 no 3102 0.0675178297491122 997 6150058 SGTC_1290 0986-0249 10.2 µM -1.50210065667301 0.0648095162890208 no 3103 0.0665355576644091 1022 53329 SGTC_2054 5233173 129 µM -1.50442741011844 0.064513414844965 no 3104 0.0662356755103196 889 6889 SGTC_1449 4112-4002 201 µM -1.50447921926579 0.0645068336208696 no 3105 0.0662290100547608 1020 2059539 SGTC_1022 4477-0945 21.3 µM -1.51015846554767 0.063788566198862 no 3106 0.0655014970055244 1015 4648966 SGTC_1910 st062352 60.4 µM -1.5105083110326 0.0637445246672248 no 3107 0.0654568851524904 1017 2245730 SGTC_3172 9105863 49.47 µM -1.51400636494911 0.0633054595456463 no 3108 0.0650121125865404 1058 2348785 SGTC_867 0518-0118 155 µM -1.51538237469114 0.0631333935951697 no 3109 0.0648377991304403 1001 6848158 SGTC_1400 3771-8998 51.5 µM -1.51811055943548 0.0627933192908874 no 3110 0.064493264818187 1051 670767 SGTC_2802 7925815 54.55 µM -1.51941322365412 0.0626314436134058 no 3111 0.0643292577438944 1021 1262923 SGTC_2727 riluzole 51.77 µM -1.52638935822192 0.0617700826290107 no 3112 0.0634564631623096 1032 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_212 3807-4682 38.772 µM -1.53248591502113 0.0610249224784383 no 3113 0.0627012853532396 1024 3125501 YBL034C STU1 SGTC_1666 st014829 29 µM -1.53500865712079 0.0607186398693386 no 3114 0.0623908507752235 1044 3858230 SGTC_492 tmb-8 126 µM -1.54293281417895 0.0597643940191073 no 3115 0.061423539044251 1021 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_687 k029-0044 34.9 µM -1.54652136345043 0.0593361358953665 no 3116 0.0609893523475733 1042 5829338 SGTC_2992 9074591 71.4286 µM -1.55013287858954 0.0589075699782173 no 3117 0.0605548130174467 1020 17741321 SGTC_907 3448-6986 75.5 µM -1.55058602748522 0.0588539683054448 no 3118 0.0605004613647497 1026 590582 SGTC_378 3970-0959 8.33 µM -1.55122025312503 0.0587790118672037 no 3119 0.0604244550819787 1044 6615653 SGTC_56 0957-0365 83.25 µM -1.55374223762579 0.0584816903000387 no 3120 0.0601229568347057 1023 6752360 SGTC_934 2950-0684 338 µM -1.55807282245952 0.0579739057999917 no 3121 0.0596079931755397 1017 1121253 SGTC_2467 5474540 200 µM -1.5607782862495 0.0576584383789155 no 3122 0.0592880362091182 1012 5413519 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.56775882268221 0.0568507150123158 no 3123 0.0584687140239978 1001 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_584 0986-0246 15.4 µM -1.56956610429527 0.0566430520087014 no 3124 0.0582580446772093 1044 53315 YDR232W HEM1 SGTC_167 3672-0051 66.205 µM -1.56991556023895 0.0566029673280635 no 3125 0.0582173785360995 1017 3237971 SGTC_798 1287-0182 476 µM -1.57375738113293 0.0561637596213853 no 3126 0.0577717752111727 1054 1649755 SGTC_80 0159-0065 512.242 µM -1.57911893835782 0.0555553086564803 no 3127 0.0571543892650498 1021 1548079 SGTC_791 1348-1292 225 µM -1.58101686441806 0.0553411756429934 no 3128 0.0569370908862324 1043 5437054 SGTC_3259 9138485 49.47 µM -1.5847408205925 0.0549229157356345 no 3129 0.0565126165737089 1021 17646153 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.5869401676182 0.054677069701594 no 3130 0.0562630982075015 1020 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3098 9119039 49.47 µM -1.59670621613323 0.0535959005275333 no 3131 0.0551656046906727 1023 17161528 SGTC_66 0109-0187 42.4 µM -1.60910837935583 0.0522473848717023 no 3132 0.0537963226665436 1018 759417 SGTC_1336 1486-0901 104 µM -1.61028714640909 0.0521206297008871 no 3133 0.0536675919934878 1025 5006114 SGTC_935 2996-0153 430 µM -1.61572113179144 0.05153945792973 no 3134 0.0530773100098453 1039 23738523 SGTC_1282 0886-0010 32.4 µM -1.61650351389305 0.0514562071726715 no 3135 0.0529927471441847 1011 2836211 YNL267W PIK1 SGTC_933 2914-0560 114 µM -1.62064337382318 0.051017476665188 no 3136 0.0525470722007814 1025 463887 SGTC_3066 9117245 49.47 µM -1.62113623342839 0.0509654437412718 no 3137 0.0524942123565398 1021 17176980 SGTC_3113 9123498 49.47 µM -1.62743332637644 0.0503043486027996 no 3138 0.0518225491597807 1058 8897275 SGTC_26 0302-0163 425.158 µM -1.63013300968106 0.0500230258029108 no 3139 0.0515366942381603 1061 3100915 SGTC_3112 9123419 49.47 µM -1.63328943969832 0.0496956997070058 no 3140 0.0512040683753901 1050 17015854 SGTC_2965 9082772 38.63 µM -1.63678075137407 0.0493356388391948 no 3141 0.0508381445377925 888 16459634 SGTC_442 cape 100 µM -1.63678493762484 0.0493352083624493 no 3142 0.0508377070305608 1050 5281787 SGTC_1616 st002734 56.1 µM -1.63986217113865 0.0490195835175551 no 3143 0.0505169139330149 1045 4026101 SGTC_206 4546-0025 72.014 µM -1.6447249056846 0.0485241146392013 no 3144 0.0500132771557725 1038 6620745 YIL048W NEO1 SGTC_612 0302-0167 22.4 µM -1.6464572436327 0.0483485754201257 no 3145 0.0498348279716147 1043 235821 SGTC_729 4092-0585 94.1 µM -1.65519102206792 0.0474712965099514 no 3146 0.0489428779005649 1024 2169061 SGTC_1297 1068-0111 14.1 µM -1.66411161292021 0.0465884649648771 no 3147 0.0480450633810254 1031 767057 SGTC_2195 6536160 144.242 µM -1.66770531961717 0.0462365556807828 no 3148 0.0476871194460154 1042 3834386 SGTC_1283 0922-0125 16.4 µM -1.66916600783785 0.0460941311070352 no 3149 0.0475422423410582 1020 3360884 SGTC_2864 9034755 47.6 µM -1.67055164317491 0.0459593504776722 no 3150 0.0474051353741035 1027 4930451 SGTC_1406 3909-7906 11.9 µM -1.6709484760383 0.0459208089602005 no 3151 0.0473659276492202 1004 X1406 SGTC_1917 st066507 28.5 µM -1.67613633513938 0.0454193347304499 no 3152 0.046855745518532 1018 3156428 SGTC_884 0851-0618 334 µM -1.67966940183987 0.0450803458077379 no 3153 0.0465108281353248 1032 9642473 SGTC_669 0108-0021 26.2 µM -1.68626595413445 0.0444528746077988 no 3154 0.0458722927467898 1036 17201 SGTC_1816 st051957 91.6 µM -1.68707643908588 0.0443762681852208 no 3155 0.0457943274021455 1066 674121 SGTC_535 2293-4129 48.2 µM -1.69025483001466 0.0440768751563197 no 3156 0.0454896063472566 1053 396118 YIL048W NEO1 SGTC_2617 dihydrotanshinone i 20.83 µM -1.69045758762734 0.0440578315121389 no 3157 0.0454702228770233 1033 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2451 5856223 45.7 µM -1.69165696150503 0.0439453181312336 no 3158 0.0453556994784642 1032 2179896 SGTC_2183 6420625 130.508 µM -1.69384553780011 0.0437406048860476 no 3159 0.0451473191399835 1031 2897619 SGTC_156 3474-0145 5.642 µM -1.70303492615381 0.0428894382876671 no 3160 0.0442807662509562 1031 2265471 SGTC_2993 9054257 71.4286 µM -1.70520454869066 0.0426904428814991 no 3161 0.0440781409863879 1019 6470217 YGL055W OLE1 SGTC_2529 gangaleoidin 93.61 µM -1.70912839759131 0.0423324478036698 no 3162 0.0437135842025369 1055 4565183 SGTC_1076 itraconazole 331 nM -1.71997789607494 0.0413552142934778 no 3163 0.0427182297884916 1050 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2387 9077560 195.08 µM -1.7290156094743 0.0405552020227737 no 3164 0.0419031507092703 1031 5303272 SGTC_2026 5148700 152 µM -1.73039660056123 0.0404340715084988 no 3165 0.0417797203975137 1058 79838 SGTC_2120 5538279 151.968 µM -1.73120507297719 0.0403632946099 no 3166 0.0417075974466338 1051 2058197 SGTC_33 0986-0033 35.816 µM -1.7327595094474 0.0402274957251765 no 3167 0.0415692111950553 1026 2848082 SGTC_1408 3909-7976 48.8 µM -1.73746524749352 0.0398186533014947 no 3168 0.0411525415278533 1047 24152374 SGTC_842 0271-0008 11.1 µM -1.73843797551198 0.039734563768216 no 3169 0.0410668350715567 1035 1221709 SGTC_1023 4482-3888 16 µM -1.74298146882463 0.0393437021088878 no 3170 0.040668425921764 1046 3303168 SGTC_712 r015-0009 80.6 µM -1.74828285638464 0.0388916021171702 no 3171 0.0402075301574506 1059 6813872 YLR060W FRS1 SGTC_316 k060-0003 58.6 µM -1.75055366713175 0.0386992469843231 no 3172 0.0400114110852025 1061 6152314 SGTC_271 rotenone 740 µM -1.75349634983243 0.038451132874031 no 3173 0.0397584227641422 1058 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1471 k673-0312 37 µM -1.75630512717987 0.0382155200257328 no 3174 0.0395181611450029 1052 24099884 SGTC_621 3584-0052 32.1 µM -1.75757167093622 0.0381096624664916 no 3175 0.0394102085327807 1043 2273927 SGTC_2029 5175081 200 µM -1.75841133938953 0.0380396150175922 no 3176 0.0393387725589537 1051 1380876 SGTC_294 k038-0071 157 µM -1.76482425444669 0.0375080896232946 no 3177 0.0387966534945419 1059 24152826 SGTC_1399 3562-5772 25 µM -1.76523654868849 0.0374741257391499 no 3178 0.038762009215807 1044 23847490 SGTC_524 r073-0010 27.8 µM -1.78201237527671 0.0361133333447703 no 3179 0.0373736068372183 1047 2772106 SGTC_305 1682-2595 20.8 µM -1.78362303759039 0.0359848391469082 no 3180 0.0372424697867088 1040 226033 SGTC_2635 hydroquinidine 100 µM -1.78778916347906 0.0356542134264764 no 3181 0.0369050149276561 1055 442912 An experimental heart treatment. SGTC_3256 9138902 49.47 µM -1.79274352798549 0.0352642780818751 no 3182 0.0365069715003358 1076 17228773 SGTC_19 0279-0214 38.434 µM -1.7955864178027 0.0350421113104147 no 3183 0.0362801587941215 1065 3566274 YBR002C RER2 SGTC_1082 camptothecin 424.86 nM -1.79561838402442 0.0350396197526964 no 3184 0.0362776150240772 1002 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1787 fluconazole 80 µM -1.79708965503518 0.0349251010475813 no 3185 0.0361606938800063 1029 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_42 0133-0086 60.653 µM -1.80009483746228 0.0346921425070952 no 3186 0.035922832319321 1040 162923 Model of phenazepam hydroxylation. SGTC_2923 7992654 58.14 µM -1.80262391845341 0.0344970810836963 no 3187 0.0357236490142158 1035 2985126 SGTC_1167 k781-0610 148 µM -1.80702787728678 0.0341595662582057 no 3188 0.0353789663497956 1034 4525169 SGTC_2343 7990716 14.84 µM -1.80850004373322 0.0340473482064911 no 3189 0.0352643550076405 1056 6456862 SGTC_2865 9030313 51.95 µM -1.8118569949586 0.0337925931539492 no 3190 0.0350041479037057 1054 42562754 SGTC_1914 st062367 72.6 µM -1.81215847149384 0.033769791404539 no 3191 0.0349808568890478 1046 978205 SGTC_1523 st012844 44.7 µM -1.8131001942912 0.0336986470565876 no 3192 0.0349081846131077 1046 4274103 SGTC_844 0330-0132 15.3 µM -1.81503084929507 0.033553177434631 no 3193 0.03475958439969 1052 2828079 SGTC_563 tetrahydrosecaminediol 614 µM -1.81636116443698 0.0334532428934029 no 3194 0.034657494194872 1057 334274 A psychoactive constituent of the cannabis plant. SGTC_938 3126-1755 342 µM -1.81758607741593 0.0333614430843691 no 3195 0.0345637105833061 1042 1777771 SGTC_1249 0481-0015 10.2 µM -1.82088862031599 0.0331149706598938 no 3196 0.0343118946802421 1042 4227577 SGTC_2028 5153890 36.43 µM -1.82522232552592 0.0327938193664553 no 3197 0.0339837430403976 1065 2830968 YPR165W RHO1 SGTC_2418 pentamidine 31.67 µM -1.82592364937635 0.0327420896105982 no 3198 0.0339308816658598 1000 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2453 5731132 22.18 µM -1.83197634589645 0.0322984319632537 no 3199 0.033477472407809 1058 1362040 SGTC_2031 5180455 200 µM -1.8347688252299 0.0320954243543444 no 3200 0.033269974792849 1056 29949 SGTC_2936 9038235 15.59 µM -1.83633666246999 0.0319819082815692 no 3201 0.0331539403386125 1033 4749415 SGTC_1293 1000-1278 195 µM -1.83924428028321 0.0317722657301503 no 3202 0.0329396322170267 1056 678847 SGTC_490 phenamil 164 µM -1.85104356617594 0.0309331431180446 no 3203 0.0320816428919921 987 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2464 5717415 7.67 µM -1.85236311490577 0.0308404524550238 no 3204 0.0319868490832871 1058 5285744 SGTC_3184 9108758 49.47 µM -1.85601136653795 0.0305853798062958 no 3205 0.0317259689652462 1071 902885 SGTC_797 k781-0471 270 µM -1.8602929138002 0.0302882604685801 no 3206 0.0314220477871088 1032 23738129 SGTC_3067 9117431 49.47 µM -1.86207064739951 0.0301655988345776 no 3207 0.0312965663853755 1063 17150885 SGTC_2087 5276107 200 µM -1.86750646314205 0.0297930857835979 no 3208 0.0309154475547453 1049 144405 SGTC_2937 9044753 11.33 µM -1.87333943714376 0.0293976087019603 no 3209 0.030510763653268 1035 6465530 YGL099W LSG1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.88402597578109 0.0286843674033362 no 3210 0.0297807309703783 1045 5355888 SGTC_3187 9109394 49.47 µM -1.89223524313828 0.0281462887684693 no 3211 0.029229822306677 1054 17098090 SGTC_2181 6316240 54.2555 µM -1.89266092327906 0.0281186181780426 no 3212 0.0292014880988032 1060 12779990 SGTC_2569 tetrandrine 100 µM -1.89916675436122 0.0276985288506046 no 3213 0.0287712772031125 1050 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1733 st037357 54.9 µM -1.90201891260977 0.0275160176112074 no 3214 0.0285843410633877 1042 1272339 YGL099W LSG1 SGTC_874 0599-0792 117 µM -1.90345323846048 0.0274246138286558 no 3215 0.0284907149220576 1053 765305 SGTC_1915 st067105 30.6 µM -1.90410326193542 0.027383273910236 no 3216 0.0284483684896207 1049 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1767 st044992 70.3 µM -1.91077692615534 0.0269618429366734 no 3217 0.0280166270658195 1058 9600693 SGTC_3047 9092122 49.47 µM -1.9131084633078 0.0268158921603439 no 3218 0.0278670842589481 1054 17173831 SGTC_2789 5281112 71.43 µM -1.91590225612457 0.0266418742940332 no 3219 0.0276887691372701 1042 765948 SGTC_361 000s-0510 1.45 µM -1.92344817058673 0.0261765684662264 no 3220 0.0272118948345094 1043 660 SGTC_2330 7979373 200 µM -1.9304803338559 0.025749078338758 no 3221 0.0267736748203549 1038 1863007 SGTC_1123 mangostin 811.285 nM -1.94771580750014 0.0247259774065352 no 3222 0.02572448879817 1037 5281650 An antioxidant. SGTC_452 diindolylmethane 8 µM -1.95946580288996 0.0240482237056504 no 3223 0.0250291304795597 1064 3071 Inhibits expression of several cancer promoting factors. SGTC_2345 9052315 157.45 µM -1.96179824740618 0.0239155591633783 no 3224 0.0248929889112686 1049 6469265 SGTC_284 0988-0104 32.6 µM -1.96974532471695 0.0234681555215669 no 3225 0.0244337828002847 1052 4666532 SGTC_2238 6671620 73.2395 µM -1.97097421013135 0.0233996044971824 no 3226 0.024363412893452 1046 729941 SGTC_38 0929-0051 58.268 µM -1.97213848298167 0.0233348132759882 no 3227 0.0242968999594946 1055 1379719 SGTC_1292 0kpi-0043 232 µM -1.97377145730355 0.0232441934830731 no 3228 0.0242038678683767 1068 3333905 SGTC_3044 9093193 49.47 µM -1.99166561374732 0.0222704435362828 no 3229 0.0232038794873854 1058 25236277 SGTC_228 caffeine 993.056 µM -2.00071509233691 0.0217912456961151 no 3230 0.0227115510205545 1063 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_222 nsc-310342 10.666 µM -2.00097813234868 0.0217774481943102 no 3231 0.022697373267511 1074 432556 SGTC_3330 9141424 71.43 µM -2.00125446114018 0.0217629615913945 no 3232 0.0226824872895997 1056 27261020 SGTC_565 1418-0001 44.5 µM -2.00739089510985 0.0214433490632273 no 3233 0.0223540287667781 1071 2862145 SGTC_937 3122-0005 46.7 µM -2.01929619849272 0.0208345775036467 no 3234 0.0217282213871979 1062 759535 SGTC_2475 5812728 15.03 µM -2.02079515481477 0.0207589764112824 no 3235 0.0216504873013146 1064 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2528 xanthyletin 44.79 µM -2.02152679080669 0.0207221601906378 no 3236 0.0216126309484847 1060 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1038 k292-0204 154 µM -2.02957349057307 0.0203208823365104 no 3237 0.0211999559018953 1067 4454212 SGTC_182 3448-4371 550.524 µM -2.02960557302415 0.0203192957067916 no 3238 0.0211983239874723 1063 3491403 SGTC_2210 7115885 190.385 µM -2.03555416875422 0.0200269186049334 no 3239 0.0208975719658179 1083 2927039 SGTC_2117 5521686 200 µM -2.04047900863211 0.0197875674385154 no 3240 0.020651319846407 1066 803312 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.04134240764984 0.0197458566938834 no 3241 0.0206084023213819 1062 1241132 A phosphatase inhibitor. SGTC_916 4466-0038 42 nM -2.04588430829226 0.0195276648001906 no 3242 0.0203838772751032 1066 5722064 YGL116W CDC20 SGTC_1165 k072-0275 30.3 µM -2.05370750218286 0.0191566412448852 no 3243 0.0200020050051623 1066 6153523 YGL055W OLE1 SGTC_1281 0884-0031 11.8 µM -2.06080243822987 0.0188253549974307 no 3244 0.0196609458916114 1070 1548255 SGTC_286 k060-0067 22.9 µM -2.09559788927183 0.0172703518726724 no 3245 0.0180589383135829 1074 5985051 SGTC_3035 9091303 49.47 µM -2.09740038961205 0.0171928794111423 no 3246 0.0179790733172358 1083 25237002 SGTC_312 4092-0653 6.84 µM -2.10896334083767 0.0167029263147932 no 3247 0.017473873027109 1044 1148278 SGTC_656 4090-1979 187 µM -2.11008112530182 0.0166562023245227 no 3248 0.0174256843793985 1072 22330961 SGTC_1295 1013-0063 9.78 µM -2.13298688187438 0.0157230695287079 no 3249 0.0164629011660292 1070 6826038 SGTC_2775 cyproheptadine 69.59 µM -2.13712300500717 0.0155594421637965 no 3250 0.0162939941463203 1074 2913 A selective serotonin reuptake inhibitor. SGTC_2020 4017018 200 µM -2.13845927634829 0.0155068918116367 no 3251 0.0162397429694878 1078 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_218 alverine citrate 93.75 µM -2.14259051432972 0.0153453887545494 no 3252 0.0160729967530383 1061 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1287 0971-0001 34.6 µM -2.1641164604839 0.0145270459185087 no 3253 0.0152277062613147 1066 4665869 SGTC_910 3454-3003 490 µM -2.1879158452773 0.0136662673423801 no 3254 0.0143378664380389 1060 820824 SGTC_518 1021-0119 62.6 µM -2.18827883121168 0.0136534871023575 no 3255 0.0143246489528041 1071 1097762 SGTC_1021 4476-0760 85.3 µM -2.19390388952315 0.013456750734473 no 3256 0.0141211598618022 1078 746768 SGTC_39 0986-0283 58.349 µM -2.20855741239991 0.0129556979078213 no 3257 0.0136027201553751 1060 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1284 0929-0043 16 µM -2.21031409636735 0.0128967277472438 no 3258 0.0135416854897938 1073 1239883 SGTC_784 4579-0127 173 µM -2.22439221622857 0.0124324668731629 no 3259 0.0130610335508344 1080 1948547 SGTC_373 0844-0104 25.9 µM -2.22998223835811 0.0122521767425973 no 3260 0.0128743110288096 1068 5375804 SGTC_1288 0973-0013 65.5 µM -2.23090404650098 0.012222665098025 no 3261 0.0128437428238355 1081 4315430 SGTC_3046 9092212 49.47 µM -2.23607248763478 0.0120583360873997 no 3262 0.0126735116452921 1083 25236637 SGTC_1681 tripelennamine 100 µM -2.24015661022394 0.0119298408822784 no 3263 0.0125403787180741 1061 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_959 1222-0044 107 µM -2.26794468166604 0.0110866914777739 no 3264 0.0116662892669714 1074 6083612 SGTC_264 promethazine 12.5 mM -2.27417014577931 0.0109050660034476 no 3265 0.0114778792428104 1074 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2785 7756463 72.73 µM -2.29361308812491 0.0103543956666597 no 3266 0.0109063664676283 1071 2201551 SGTC_846 0335-0850 148 µM -2.30031838856988 0.0101701897722398 no 3267 0.0107150943182671 1076 6819598 SGTC_288 1315-0019 35.1 µM -2.31247807074996 0.00984342690908245 no 3268 0.0103756762119529 1057 6811474 SGTC_1291 0993-0025 5.79 µM -2.33115004333633 0.00935950997769091 no 3269 0.00987272464464096 1071 4353356 SGTC_525 k781-2675 26.7 µM -2.34052036795763 0.00912460032573827 no 3270 0.00962844400309555 1057 3651118 YDL195W SEC31 SGTC_2850 9015429 58.44 µM -2.34292209798047 0.00906522757269752 no 3271 0.00956668881575701 1075 6457570 SGTC_863 0466-0191 129 µM -2.34384948806582 0.00904239242232076 no 3272 0.00954293584941315 1085 765160 YPR165W RHO1 SGTC_2416 tofa 880 nM -2.34400254382898 0.00903862857334327 no 3273 0.00953902063847622 1065 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_968 1309-0633 340 µM -2.36578186363157 0.0085168394349125 no 3274 0.00899602090940716 1081 3761976 SGTC_457 grayanotoxin iii 135 µM -2.37002673751359 0.0084182764324388 no 3275 0.00889339946447271 1054 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2496 diffractaic acid 79.83 µM -2.39002934059087 0.00796718440436007 no 3276 0.00842351342743248 1076 94870 An apoptosis inducer which activates caspases. SGTC_414 piperonyl butoxide 100 µM -2.39469013994762 0.00786518031428499 no 3277 0.00831720809726116 1080 5794 A potent inhibitor of cytochrome P450. SGTC_2131 toluylene red 5.2905 µM -2.39680702842051 0.00781923168288136 no 3278 0.0082693155788434 1071 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2452 5863136 48.41 µM -2.40823476577239 0.00757524026660255 no 3279 0.00801493464500206 1077 2184096 SGTC_155 k072-0202 43.6 µM -2.41847560804296 0.0073623123282541 no 3280 0.00779284523095155 1078 5857737 SGTC_1373 2887-0003 58.5 µM -2.43235762632799 0.0070821063080846 no 3281 0.00750044385856641 1083 776948 SGTC_429 1112-0049 25.5 µM -2.43674013437672 0.00699562210956693 no 3282 0.00741016279454596 1080 2836170 SGTC_970 1315-0089 19.5 µM -2.45550698383999 0.0066357326568386 no 3283 0.00703430095454748 1076 6811083 YLR033W RSC58 SGTC_607 4491-0986 66.8 µM -2.45829101807035 0.00658376172871116 no 3284 0.0069799999319236 1037 698981 YDR232W HEM1 SGTC_2855 9016525 58.44 µM -2.46928481932814 0.00638203497791229 no 3285 0.00676917071295546 1075 43811474 SGTC_367 0335-0881 7.1 µM -2.47379587276252 0.00630085662644733 no 3286 0.00668430281210943 1077 23828853 SGTC_542 3381-0244 89.3 µM -2.48083238735727 0.00617605600773059 no 3287 0.00655379962408739 1086 1112843 SGTC_2773 thioridazine 9.09 µM -2.48230489675998 0.0061502181430016 no 3288 0.00652677647773052 1087 5452 An antipsychotic. SGTC_3033 9090887 49.47 µM -2.51015162374935 0.00567930127856771 no 3289 0.00603396661554934 1067 19325384 SGTC_635 k038-0028 24.7 µM -2.52069281738276 0.00550956834028119 no 3290 0.00585620245674936 1084 4035102 SGTC_2495 cafestol 54.53 µM -2.52664955736621 0.00541566002292799 no 3291 0.00575781730446971 1076 16667697 An anti-infammatory. SGTC_1739 st037196 92.5 µM -2.52774042601366 0.00539861739460988 no 3292 0.00573995961759117 1076 612214 SGTC_2405 ticlatone 3.52 µM -2.53666634629864 0.00526094939919261 no 3293 0.00559567798766386 1069 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3036 9090181 49.47 µM -2.58277947950273 0.00459828498580558 no 3294 0.00490039727462187 1089 25236586 SGTC_1285 0929-0069 65.5 µM -2.61785954909126 0.00414516610236759 no 3295 0.00442416081086817 1089 1206237 SGTC_1674 st016616 23.6 µM -2.63124904361949 0.00398303764984219 no 3296 0.00425358352016938 1076 625830 SGTC_1286 0929-0070 131 µM -2.6545496358126 0.00371439288640905 no 3297 0.00397071775908414 1083 1420408 SGTC_1850 st056238 17 µM -2.67033598958245 0.00354173768289763 no 3298 0.00378876902212748 1078 5393177 SGTC_790 1575-0012 79.1 µM -2.68637404146448 0.00337374256498202 no 3299 0.00361160884907131 1076 378741 YLR208W SEC13 SGTC_822 1487-0950 154 µM -2.69169749504361 0.00331958475389635 no 3300 0.00355446968978458 1077 1958375 SGTC_1289 0976-0073 69.1 µM -2.71198748273798 0.00312026090278097 no 3301 0.00334405591733344 1087 3391136 SGTC_1037 k284-1091 78.7 µM -2.75953932965791 0.00269469425620288 no 3302 0.00289414596712397 1080 3334711 SGTC_2241 6772625 37.8075 µM -2.7631008918024 0.00266503462749383 no 3303 0.00286275327523255 1068 2285411 SGTC_2406 ethylparaben 405.7 µM -2.76454843600457 0.00265306441058255 no 3304 0.00285008219302192 1084 8434 A possible steroid mimic. SGTC_576 1073-0113 22.7 µM -2.78423212990697 0.00249504424075343 no 3305 0.00268273097425176 1085 5439563 SGTC_85 0868-0259 160.055 µM -2.8049468455942 0.0023379834329837 no 3306 0.00251624390569177 1080 83173 SGTC_1919 st067113 52.3 µM -2.81374979457699 0.00227399210744473 no 3307 0.00244836625803433 1078 1268243 SGTC_2784 7567673 72.73 µM -2.83391403379315 0.00213335055795732 no 3308 0.00229908498708356 1079 3471247 SGTC_363 0455-0021 3.06 µM -2.8555148933142 0.00199148067486473 no 3309 0.00214835538110491 1065 4597466 SGTC_1683 st010134 710 nM -2.91181140191257 0.00166108158829657 no 3310 0.00179669763748249 1089 3818134 SGTC_2853 9015042 58.44 µM -2.91803070428451 0.00162782526422956 no 3311 0.00176124831302346 1085 6457456 SGTC_865 0488-0499 301 µM -2.94558050735313 0.00148768283237201 no 3312 0.00161174623966688 1087 9634651 SGTC_632 0781-2353 4.65 µM -3.02077782243883 0.00115934006774529 no 3313 0.00126063144410548 1093 6811515 YHR007C ERG11 SGTC_1457 k015-0032 57.3 µM -3.02252704114385 0.00115256122782128 no 3314 0.00125336842710718 1088 4302660 SGTC_2023 5144124 124 µM -3.07446273929839 0.000967104924469162 yes 3315 0.00105441030878373 1081 2830192 SGTC_350 k064-0020 19.8 µM -3.11902500031397 0.000830263425249806 yes 3316 0.000907252823424934 1066 2790705 SGTC_2018 5133068 143 µM -3.16364818211624 0.000711292277133344 yes 3317 0.000779025067696624 1085 785362 SGTC_716 1683-5115 658 µM -3.18447840289393 0.000661321884423924 yes 3318 0.000725075657439418 1094 723597 SGTC_3206 9114350 49.47 µM -3.20830273245459 0.000608150359171132 yes 3319 0.000667604357732836 1090 17087243 SGTC_1638 st008370 60.6 µM -3.20838403125964 0.000607975876354566 yes 3320 0.000667415647167897 1083 24207134 SGTC_2489 cantharidin 73.42 µM -3.21590594034091 0.000592031016067811 yes 3321 0.000650167219662824 1087 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1637 st007924 17.4 µM -3.25816118798479 0.000509415235939677 yes 3322 0.000560683461315627 1085 683336 SGTC_370 0180-0345 38.7 µM -3.39266319188756 0.000312164544584999 yes 3323 0.000346083441099216 1071 3989527 SGTC_1789 tunicamycin 25 nM -3.39553027610614 0.000308864646001185 yes 3324 0.000342478989666599 1086 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1730 st033808 45.1 µM -3.51105423538254 0.000199967031861531 yes 3325 0.000223166663599699 1088 1045166 SGTC_426 0988-0037 14.6 µM -3.61024936797232 0.000136270786851018 yes 3326 0.000152951382914226 1093 5383008 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -3.72992294804489 8.4721953093539e-05 yes 3327 9.57691677782297e-05 1092 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1460 k062-0059 9.15 µM -4.39798731216808 4.6264605963574e-06 yes 3328 5.46296822716366e-06 1074 1373085 SGTC_1213 1315-0166 115 µM -4.55247542286885 2.22028219774122e-06 yes 3329 2.65091781314334e-06 1095 768401 SGTC_2575 plumbagin 510 nM -4.64556817430836 1.41054957265665e-06 yes 3330 1.69570875183374e-06 1095 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1212 0520-0165 585 µM -5.51723855366239 1.33458735672701e-08 yes 3331 1.72183921211284e-08 1095 5403258 SGTC_1240 0356-0016 42.1 µM -7.22840232162168 1.59312926488623e-13 yes 3332 2.44354568574962e-13 1094 4305613 SGTC_1461 k072-0203 53.8 µM -8.07691770141552 1.95410747440598e-16 yes 3333 3.32121713067344e-16 1074 5418714 SGTC_1214 0358-0031 63.7 µM -11.9423553809666 1.13856406594592e-33 yes 3334 3.55892796722475e-33 1095 4301366 SGTC_1462 k081-0014 26.5 µM -15.0293651783756 3.92347120612067e-52 yes 3335 2.35751306553382e-51 1074 3270634 SGTC_1463 k081-0032 34.1 µM -15.5075169225321 2.29001615561009e-55 yes 3336 1.54291755226513e-54 1074 977755