SGTCid condition conc unit PZF1|YPR186C.score PZF1|YPR186C.strain.pval PZF1|YPR186C.strain.significant PZF1|YPR186C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2602 kawain 100 µM 5.72226623723635 7.13934699230918e-10 yes 1 5.25562082108296e-09 2 5369129
SGTC_2428 5615643 7.78 µM 5.20145304140164 1.89827720669575e-08 yes 2 9.8868218329565e-08 4 2253075
SGTC_1713 st033146 12.748 µM 4.74469442993875 2.64148285034081e-07 yes 3 1.04410660370374e-06 5 674619
SGTC_1129 3453-1384 223 µM 4.68312606617654 3.70198182435528e-07 yes 4 1.41266313538288e-06 11 1084452
SGTC_2975 9084847 53.72 µM 4.3892538475058 1.75176787783279e-06 yes 5 5.68701200165418e-06 4 27211724
SGTC_2143 5623677 140.463 µM 4.31193501092162 2.59613910830489e-06 yes 6 8.09160028066305e-06 1 5375313
SGTC_1369 1866-0067 208 µM 4.30045859315861 2.75073013112354e-06 yes 7 8.52225090670452e-06 8 3531355
SGTC_2015 5119600 184 µM 4.17084429087382 5.23432995527527e-06 yes 8 1.51736588977347e-05 7 2828786
SGTC_1470 k295-0292 231 µM 3.9985970068319 1.19673297267886e-05 yes 9 3.18595325107645e-05 3 5045612
SGTC_2539 epi(13)torulosol 80 µM 3.98514125301431 1.27487650254005e-05 yes 10 3.37199978619983e-05 4 6708597
SGTC_564 3555-0129 330 µM 3.93580604680942 1.60496596410279e-05 yes 11 4.14589602006293e-05 2 563260
SGTC_3200 9114385 49.47 µM 3.80139735348804 2.96577233563907e-05 yes 12 7.19411721915331e-05 23 17018030 YLR208W SEC13
SGTC_1717 st033143 58.0435 µM 3.74893744876503 3.74918366894476e-05 yes 13 8.87926835111879e-05 6 674616
SGTC_164 4100-3994 89.624 µM 3.70458758436424 4.56036292446476e-05 yes 14 0.000105867470525313 8 4615967
SGTC_323 4013-0906 34.3 µM 3.65056598482234 5.77268254673267e-05 yes 15 0.000130831537229864 3 2910086
SGTC_1714 st033236 13.627 µM 3.6469551866663 5.86370768332434e-05 yes 16 0.000132683091389492 10 2916566
SGTC_1494 4358-1428 177 µM 3.62004024000717 6.58611024674896e-05 yes 17 0.00014727860175329 7 1564571
SGTC_2139 5578692 56.4705 µM 3.56980807092132 8.16392727264853e-05 yes 18 0.000178621435597931 21 650991 YMR113W FOL3
SGTC_537 1334-0398 209 µM 3.56236705475457 8.4258942740023e-05 yes 19 0.000183763018271087 12 5846986
SGTC_1468 k284-1086 134 µM 3.47297036669825 0.000122576463135149 yes 20 0.000257366092224638 16 15996457
SGTC_3106 9121286 49.47 µM 3.43528310994291 0.000143195005026385 yes 21 0.000295967539595707 7 15943471
SGTC_2147 5545932 89.7195 µM 3.34334953009826 0.000207915034684353 yes 22 0.000413867848876706 16 797404
SGTC_2989 9073649 71.4286 µM 3.28948989670494 0.000257608221001458 yes 23 0.000501845799340768 17 21367202
SGTC_628 1636-0253 16 µM 3.28785523438403 0.000259276804630075 yes 24 0.000504768682371248 17 4456143
SGTC_1929 genistein trimethyl ether 50.5 µM 3.27298754833249 0.00027492223389716 yes 25 0.000532085827473463 9 136420
SGTC_2955 9076254 12.21 µM 3.2071195308141 0.000355403076396991 yes 26 0.000670356379843782 12 16459619
SGTC_2024 5144227 134 µM 3.18981159610546 0.0003799198900942 yes 27 0.000711827862281138 13 3475211
SGTC_2811 7967822 32.47 µM 3.1072448619715 0.000520002243306087 yes 28 0.0009441995618433 14 2232244
SGTC_2158 5657123 3.6195 µM 3.10419767460772 0.000525988434951699 yes 29 0.00095397904642912 24 2858827
SGTC_1880 MG-132 525 µM 3.0907342219951 0.000553208318184288 yes 30 0.000998311314214527 28 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1259 0671-0132 43 µM 3.07889255149962 0.000578220002956738 yes 31 0.00103885801416535 16 X1259
SGTC_2752 diclazuril 33.15 µM 3.0786689221571 0.000578702247119479 yes 32 0.00103963806673243 22 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 3.07780603676576 0.000580566497553826 yes 33 0.00104265297866323 37 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_517 1365-0151 113 µM 3.03316999196159 0.000684924411097769 yes 34 0.00120999618067779 18 768657
SGTC_102 gallobenzophenone 83.616 µM 3.02527374851872 0.000705095351827013 yes 35 0.00124204090461714 14 70837
SGTC_659 k018-0002 107 µM 2.99909686400013 0.000775946620219258 yes 36 0.00135390602011859 20 6797879 YHR007C ERG11
SGTC_540 1187-0821 17.3 µM 2.99127035423596 0.00079836986505132 yes 37 0.00138909705371481 17 847520
SGTC_1758 st042942 75.2445 µM 2.95315399853844 0.000916346900366763 yes 38 0.00157272501592118 13 669317
SGTC_1879 gemcitabine 100 µM 2.95247591901262 0.000918583708264799 yes 39 0.00157618328466256 8 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2086 5274770 176.623 µM 2.94542075835996 0.000942156328248623 yes 40 0.0016125787399447 24 689278
SGTC_570 0987-0065 62.6 µM 2.88146621406211 0.00118261137025261 no 41 0.00197914834347742 12 3104428
SGTC_1923 st058458 19.1 µM 2.87792271000681 0.00119744990501913 no 42 0.00200151601201923 28 3534982
SGTC_2193 5925765 200 µM 2.86042666124887 0.00127324445270922 no 43 0.00211535696991698 5 877370
SGTC_3064 1327-0027 10 µM 2.84895870429313 0.0013252788974725 no 44 0.00219312866584796 13 16000455 YPR107C YTH1
SGTC_658 3253-0951 102 µM 2.84605508352032 0.00133875852308994 no 45 0.0022132268604051 21 1184878
SGTC_1349 flufenamic acid 69 µM 2.83213700997526 0.00140512751555449 no 46 0.00231190158212624 12 3371 A non-steroidal anti-inflammatory.
SGTC_2546 rhodinyl acetate 100 µM 2.81246082047743 0.00150408680482072 no 47 0.00245820062534207 19 6708682
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.76874991208715 0.00174705544853647 no 48 0.00281359053358836 25 5106787 A p450 inhibitor.
SGTC_160 3453-0671 289.699 µM 2.74261441898042 0.00190887859917664 no 49 0.00304761053281236 22 5322268
SGTC_2195 6536160 144.242 µM 2.72154651394572 0.00204911140609279 no 50 0.00324886200807233 20 3834386
SGTC_670 4204-0025 119 µM 2.71217217310496 0.00211446328681354 no 51 0.00334219316766914 10 719039
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.68734037881486 0.00229681055626156 no 52 0.00360117584893887 14 7104
SGTC_2295 7971645 200 µM 2.65066238453451 0.00259226666407353 no 53 0.00401670497850734 15 2978226 YKL099C UTP11
SGTC_960 1222-0186 7.7 µM 2.63754832829735 0.00270597125722708 no 54 0.00417538627395043 32 3126296
SGTC_1508 1080-0625 72.9 µM 2.6058749004392 0.00299938495507613 no 55 0.00458199624576735 12 767111
SGTC_2028 5153890 36.43 µM 2.60377736403576 0.00301979234958789 no 56 0.0046101314533668 31 2830968 YPR165W RHO1
SGTC_3012 9080433 71.4286 µM 2.59152890475056 0.00314147795352157 no 57 0.00477752572336186 23 17688859
SGTC_1570 verbenone 133 µM 2.58931432490995 0.00316394462779777 no 58 0.00480836344097694 21 29025 A natural terpanoid with antifungal properties.
SGTC_1314 1222-0010 41.1 µM 2.58053630955476 0.00325442603410602 no 59 0.00493234909682357 20 3526027
SGTC_1901 st060216 58.6 µM 2.57401092078274 0.00332318901398815 no 60 0.00502635500619795 20 688792
SGTC_898 1000-0849 28.3 µM 2.56021697555356 0.00347286241678859 no 61 0.00523034150232197 26 6751807
SGTC_1272 0839-0021 27 µM 2.55558935393218 0.00352441523759798 no 62 0.00530040699672338 34 5027250
SGTC_1392 3455-1037 33.9 µM 2.55100423562367 0.00357617125638316 no 63 0.00537065102010557 21 981132
SGTC_2098 5376439 882.5 nM 2.52276621519981 0.00391022911773238 no 64 0.00582178903869212 18 2844116
SGTC_995 3931-2021 34.6 µM 2.49192965005917 0.00430672408144943 no 65 0.00635255996626569 33 730143
SGTC_843 0310-0051 143 µM 2.48649868109753 0.00438016368828527 no 66 0.00645035239074126 22 2065037
SGTC_2685 mycophenolic acid 18.85 µM 2.48017543988101 0.00446707726572019 no 67 0.0065658876551805 10 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1173 0443-0020 122 µM 2.46887082376604 0.0046263057508606 no 68 0.00677700683529899 31 5331295
SGTC_1345 1488-0192 31.4 µM 2.46494807950616 0.00468273099747891 no 69 0.00685165533010123 19 658348
SGTC_73 0327-0325 16.231 µM 2.46058334461443 0.0047462348172974 no 70 0.00693556750732476 14 53298
SGTC_443 clozapine 122 µM 2.46050294091912 0.00474741180430622 no 71 0.00693712174522023 18 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_449 xestospongin c 11.1929 µM 2.4594434093314 0.00476294605841284 no 72 0.00695763169006676 17 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.44532383297615 0.00497432907039874 no 73 0.00723610658528024 31 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_657 3534-0529 86.7 µM 2.43015976403001 0.00521061902239663 no 74 0.00754608426901076 18 1049549
SGTC_1506 4226-2149 212 µM 2.40830235451813 0.00556877768244048 no 75 0.00801345081850094 37 991114
SGTC_1256 0570-0116 285 µM 2.40004091793424 0.00570974376585543 no 76 0.00819661963167064 34 410638
SGTC_3161 9100388 49.47 µM 2.37019075301687 0.00624583941801879 no 77 0.00888945499408874 32 25236368
SGTC_934 2950-0684 338 µM 2.36200359541114 0.00640045990738222 no 78 0.00908823295960374 30 1121253
SGTC_543 3844-1095 191 µM 2.35910419943696 0.00645602385557791 no 79 0.0091595555723533 38 4230703
SGTC_827 3253-0474 693 µM 2.35314109178059 0.0065716437933881 no 80 0.00930778456008931 39 5402065
SGTC_744 1594-0068 283 µM 2.35112574075224 0.00661113178364601 no 81 0.00935835388152704 32 668392
SGTC_567 1080-0542 68.4 µM 2.33670793302145 0.0068997989493118 no 82 0.00972718788591709 28 5950415
SGTC_883 0850-0245 24.6 µM 2.32984601656319 0.00704105330149606 no 83 0.00990714553027922 42 6823229 YPR165W RHO1
SGTC_3031 9088762 49.47 µM 2.32244041070918 0.00719635735289478 no 84 0.0101046167718348 32 205253
SGTC_3208 9114115 49.47 µM 2.32045069942366 0.00723859545576284 no 85 0.0101582544773989 60 650895
SGTC_1975 st070967 30.8 µM 2.31437618724639 0.00736890232406495 no 86 0.0103235479667998 57 261391
SGTC_2276 7947513 42.08 µM 2.29732796288957 0.00774571794200049 no 87 0.0108000338906803 26 2105100
SGTC_1509 1326-1131 80 µM 2.28757260914946 0.00796888210488858 no 88 0.0110812112657387 23 768313
SGTC_3072 9116419 49.47 µM 2.28433101442326 0.00804427841269106 no 89 0.0111760422468758 36 17170162
SGTC_322 k048-0136 19.3 µM 2.28045674577562 0.00813521210188636 no 90 0.0112903066827627 38 6823282
SGTC_1958 st076513 41.9 µM 2.27716550710336 0.00821316972563239 no 91 0.0113881720326652 36 732122 YGL099W LSG1
SGTC_2891 9063876 19.48 µM 2.27499387176623 0.00826496663189751 no 92 0.0114531487289055 23 6472478
SGTC_2655 perillic acid 100 µM 2.26592955659922 0.00848427534929792 no 93 0.0117278483095632 25 5702197 An apoptosis inducer.
SGTC_3214 9129694 49.47 µM 2.26580513881095 0.00848732079976168 no 94 0.0117316583096554 38 17158655
SGTC_3330 9141424 71.43 µM 2.26050065677533 0.00861805737696008 no 95 0.0118950978583328 23 27261020
SGTC_1699 st031318 29.054 µM 2.25448552142975 0.00876844329589453 no 96 0.012082820253116 36 5340658
SGTC_1464 k208-0027 110 µM 2.24689785330383 0.00896142237515665 no 97 0.0123232779739635 37 X1464
SGTC_1298 1079-1278 263 µM 2.24375514165989 0.0090424351458906 no 98 0.012424080042531 35 2840950
SGTC_1559 coumarin 343 70.1 µM 2.23004520716302 0.00940339808175757 no 99 0.0128722209112578 26 108770 A hepatotoxic, DNA x-linker.
SGTC_1299 1079-1439 3.74 µM 2.22770487758753 0.00946625899539817 no 100 0.0129501007755302 32 323161
SGTC_979 1426-2828 121 µM 2.21880440070091 0.00970869288831827 no 101 0.013250017251661 37 747872
SGTC_501 nsc-95397 161 µM 2.21564659234624 0.00979600076570378 no 102 0.0133578576294055 36 262093
SGTC_3217 9129673 49.47 µM 2.21551321323244 0.00979970351198333 no 103 0.0133624292139391 46 17248312
SGTC_1112 tnp00069 1.16933 µM 2.20878139799723 0.00998818075702673 no 104 0.013594924762078 28 145826
SGTC_416 estradiol valerate 100 µM 2.20692876977069 0.0100406026724793 no 105 0.0136595180535408 33 13791 A steroid.
SGTC_1675 st018485 24.5 µM 2.19455286470605 0.0103969899765352 no 106 0.0140978439292998 51 3323024
SGTC_1121 fusaric acid 630.51 nM 2.19119556547786 0.0104955511114856 no 107 0.0142188216887518 34 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2013 4024628 200 µM 2.17100894983502 0.0111055119470604 no 108 0.0149652479265142 49 5230760
SGTC_530 4358-1714 28 µM 2.16678817338903 0.0112368745485944 no 109 0.0151255048201829 62 1564641
SGTC_2229 7354935 190 µM 2.15959268223477 0.0114639341315993 no 110 0.0154021077111779 53 318112
SGTC_2379 9035213 200 µM 2.1583766739655 0.0115026973763052 no 111 0.0154492788922272 48 646551
SGTC_3180 9109287 49.47 µM 2.15481093196694 0.01161702119968 no 112 0.0155883162184234 60 18891271
SGTC_2406 ethylparaben 405.7 µM 2.1544574327148 0.0116284085611409 no 113 0.0156021583731395 42 8434 A possible steroid mimic.
SGTC_1085 doxorubicin 7.67 µM 2.15286257039095 0.0116799048402793 no 114 0.0156647404450199 57 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2915 7971052 15.16 µM 2.1503494596747 0.0117614520512131 no 115 0.0157637914375811 28 5741558
SGTC_2758 dehydroepiandrosterone 69.35 µM 2.14596448422567 0.0119049224055204 no 116 0.0159379061729434 47 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2759 disulfiram 3.38 µM 2.14511448915939 0.0119329080506579 no 117 0.0159718471238222 76 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1350 1495-0454 146 µM 2.13724557656928 0.0121947086244192 no 118 0.0162890114151796 41 1069057
SGTC_2393 9031399 185.94 µM 2.13008676927268 0.0124371936191906 no 119 0.0165822252197484 60 1526623 YDL150W RPC53
SGTC_571 k831-0106 44.2 µM 2.12575189154948 0.0125860464940773 no 120 0.0167619618425497 46 4783639
SGTC_3225 9130819 49.47 µM 2.12363351528478 0.0126593474561864 no 121 0.0168504003733314 61 4547121
SGTC_1556 plumbagin 1.48 µM 2.10961882820867 0.0131536599856102 no 122 0.0174456006253569 65 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2969 9091408 28.7 µM 2.10676586209282 0.0132563053970244 no 123 0.0175689399911186 46 4286311
SGTC_667 1498-1044 59 µM 2.10342360550466 0.0133774342316393 no 124 0.0177143783909102 45 6739982
SGTC_703 3875-0075 71.8 µM 2.09828667653958 0.0135654681412371 no 125 0.0179399143839413 48 2850814
SGTC_1167 k781-0610 148 µM 2.0863921340703 0.0140096363230381 no 126 0.0184715584643093 57 4525169
SGTC_1091 telmisartan 47.6 µM 2.08209731462467 0.0141730664484092 no 127 0.0186667908941577 38 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1963 st076565 50.3 µM 2.06534729396361 0.0148262427756462 no 128 0.0194450758468246 57 4914280
SGTC_1130 3454-2858 15.9 µM 2.05608866303819 0.0151982762183995 no 129 0.0198869854032485 63 715628 YIL048W NEO1
SGTC_2093 5331342 194.4 µM 2.05558607073165 0.0152186990271282 no 130 0.0199112157823068 52 33839
SGTC_2084 5306078 60.6385 µM 2.05036143076727 0.0154324019735664 no 131 0.0201645870009172 42 679340
SGTC_330 1488-0319 80.1 µM 2.04203506981672 0.0157782980988962 no 132 0.0205740263620359 58 6846614
SGTC_1084 voriconazole 435 nM 2.02309534792191 0.0165899411890905 no 133 0.0215316590474416 60 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2842 9000675 19.48 µM 2.01947852995101 0.0167489334831359 no 134 0.0217187533176447 49 2989072
SGTC_587 k089-0003 57 µM 2.01837027806562 0.0167979114594111 no 135 0.0217763562182701 30 9659696
SGTC_2354 9060492 162 µM 2.01759917598648 0.0168320616959413 no 136 0.0218165113853631 37 6471895
SGTC_874 0599-0792 117 µM 2.01612844607592 0.0168973613976511 no 137 0.0218932731009949 59 765305
SGTC_2088 5278280 127.392 µM 2.01186888476732 0.0170877074029723 no 138 0.0221168800726327 47 791502
SGTC_1561 5-methoxyflavone 52.9 µM 2.00752112365049 0.0172838817048812 no 139 0.022347101865508 31 94525
SGTC_956 1185-0240 191 µM 2.00555059177478 0.0173734252543499 no 140 0.0224521089327777 39 1416193
SGTC_384 k007-0144 5.16 µM 2.00547367684984 0.0173769283883402 no 141 0.0224562160523433 69 6824886
SGTC_2823 7987624 58.44 µM 2.00399170550479 0.0174445434962759 no 142 0.0225354744706553 70 2239440
SGTC_2150 5556613 200 µM 1.99699644801503 0.0177667437357536 no 143 0.0229127844246865 52 743190
SGTC_2302 7771753 200 µM 1.99160785070777 0.018018390865186 no 144 0.0232070506622773 56 2203047
SGTC_234 nsc-17383 10.7 µM 1.9903174374003 0.0180791020883296 no 145 0.02327798916812 53 408974
SGTC_2271 7849410 118.62 µM 1.98922740490094 0.0181305215994503 no 146 0.0233380541651676 42 972430
SGTC_556 4058-0063 51.5 µM 1.98850725344379 0.018164561250878 no 147 0.0233778088006886 41 6615692
SGTC_1178 0988-0033 191 µM 1.98597322948306 0.018284771204956 no 148 0.0235181482581216 51 5392207
SGTC_961 1252-1571 372 µM 1.97182055643597 0.0189686854536073 no 149 0.0243150474127369 71 6813498
SGTC_1136 pergolide 1.05886 µM 1.97030696168464 0.0190431000688666 no 150 0.0244016005303284 77 47811 A dopamine receptor agonist.
SGTC_456 gingerol 170 µM 1.96567519568959 0.0192723609255871 no 151 0.02466807090975 45 442793 A herb.
SGTC_2897 9048598 12.99 µM 1.93243330793474 0.0209875669625243 no 152 0.0266530231262389 20 6467404
SGTC_864 0469-0573 172 µM 1.93240249254371 0.0209892150281321 no 153 0.0266549233207787 53 689425
SGTC_631 k072-0230 41.5 µM 1.92705906040972 0.0212766527645562 no 154 0.0269861350114082 60 5773147
SGTC_2708 st078559 56 µM 1.92168593522715 0.0215690375010848 no 155 0.027322644030812 33 17250902
SGTC_3321 9137793 26.8275 µM 1.91786668094556 0.0217789250831457 no 156 0.0275639590059046 72 4904192
SGTC_3125 9127534 49.47 µM 1.91059975963387 0.0221830453669216 no 157 0.028028017644566 36 1639235
SGTC_1621 st003705 32.4 µM 1.90653034569619 0.0224121005555578 no 158 0.028290716222262 60 24207032
SGTC_1678 st019265 80.2 µM 1.90472633485525 0.0225142793205453 no 159 0.0284078269464644 50 5367020
SGTC_727 3032-0951 202 µM 1.90080805066018 0.0227375637068208 no 160 0.0286635795998933 46 3652836
SGTC_276 colchicine 750 µM 1.89910790725432 0.0228350257651064 no 161 0.0287751448366792 58 2833 A microtubule depolymerizer.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.88919024166578 0.0234106051966703 no 162 0.0294331709149044 51 5282309
SGTC_1436 4092-1007 8.32 µM 1.88431928706285 0.0236977354563996 no 163 0.0297609000438781 49 2881121
SGTC_2069 5228469 200 µM 1.88271633289618 0.023792870725441 no 164 0.02986941040138 58 2835210
SGTC_535 2293-4129 48.2 µM 1.87708644778389 0.0241295521144292 no 165 0.0302531232601431 74 396118 YIL048W NEO1
SGTC_1117 retinoic acid 1.10837 µM 1.87434042691758 0.0242952177841441 no 166 0.0304417594037789 47 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3069 9117009 49.47 µM 1.872459369521 0.0244092511318314 no 167 0.0305715389989932 33 41904981
SGTC_161 4065-0411 162.148 µM 1.87017085019503 0.0245485911534999 no 168 0.0307300481295084 72 1906281 YLR208W SEC13
SGTC_1656 st012921 11 µM 1.86640066809471 0.0247796000186753 no 169 0.0309926648636447 50 6732821
SGTC_867 0518-0118 155 µM 1.86615530452419 0.0247946970687382 no 170 0.0310098201399709 70 6848158
SGTC_875 0709-0210 25.7 µM 1.86225204472755 0.0250359013436966 no 171 0.0312837857797205 65 6251364
SGTC_804 1595-0054 20.9 µM 1.84160675567311 0.0263446363023692 no 172 0.0327663460763228 56 761523 Stimulates phospholipase C.
SGTC_64 000l-0018 272.079 µM 1.82817499082729 0.0272264288984015 no 173 0.0337616465663631 120 6811119
SGTC_1991 st073000 8.92 µM 1.81907087168317 0.0278380059569363 no 174 0.0344503091581157 93 4301969 YIL048W NEO1
SGTC_3133 9127736 49.47 µM 1.81292965865214 0.0282569777555659 no 175 0.0349213355658699 48 27243420
SGTC_872 0588-0139 234 µM 1.81174069561038 0.0283386957939031 no 176 0.0350131361827075 49 2047100
SGTC_1252 0493-0875 34.8 µM 1.80987710477204 0.0284671770054669 no 177 0.035157423680826 52 3960963
SGTC_757 1066-0008 322 µM 1.80057334375861 0.0291158744870216 no 178 0.0358850768843323 67 6842497
SGTC_1833 st055984 71 µM 1.79517928320483 0.0294975632912443 no 179 0.0363125700423555 50 676288
SGTC_1825 st052143 62.6 µM 1.79136494233192 0.0297699693364098 no 180 0.0366173754395967 68 674173
SGTC_3019 9081971 49.47 µM 1.77618695704284 0.0308746806734493 no 181 0.0378510536624398 64 16451803
SGTC_1338 1486-1223 76 µM 1.77465575547645 0.0309879875871394 no 182 0.0379773725072033 61 3444526
SGTC_2483 5729050 27.16 µM 1.77380026870186 0.0310514421794476 no 183 0.0380480968374125 79 2865180
SGTC_1322 1348-1070 12 µM 1.77044857337876 0.0313010863136712 no 184 0.0383262220869856 56 6758089
SGTC_3254 9136651 49.47 µM 1.76738632854169 0.0315306200935603 no 185 0.0385817754787119 75 16454030
SGTC_2692 st077426 47.7 µM 1.76130617764493 0.0319904884442762 no 186 0.0390932975139973 86 25238571
SGTC_939 1165-0479 45.3 µM 1.75125194932081 0.0327630772145478 no 187 0.0399512603003721 65 1377347
SGTC_2200 6600604 21.907 µM 1.74855692318349 0.0329727634783949 no 188 0.0401838189627744 74 2904777
SGTC_255 tunicamycin 200.472 nM 1.74724914682794 0.0330749127506446 no 189 0.0402970649848697 80 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_465 cgp-37157 41 µM 1.74065441210447 0.0335940017988622 no 190 0.040872086870398 49 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2648 atorvastatin 78.68 µM 1.74059412689977 0.0335987777583557 no 191 0.0408773739273818 62 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_635 k038-0028 24.7 µM 1.73932767463996 0.0336992388373608 no 192 0.040988571039168 89 4035102
SGTC_217 ketoconazole 989 nM 1.73658080928989 0.0339179829844928 no 193 0.0412305946522788 66 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_907 3448-6986 75.5 µM 1.72987567417195 0.0344568483657869 no 194 0.0418262451604363 76 590582
SGTC_2665 lovastatin 100 µM 1.72758519721815 0.0346425290814481 no 195 0.0420313092974028 58 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3295 9122362 53.5725 µM 1.711208889151 0.0359941677778647 no 196 0.0435212791568104 86 4730473
SGTC_904 1141-0088 396 µM 1.70498473249158 0.0365190853751746 no 197 0.044098635953359 63 1378119
SGTC_1312 1218-2183 165 µM 1.70160357076691 0.0368068527493984 no 198 0.0444148538505033 77 6744073
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.70142630362924 0.0368219907953637 no 199 0.0444314827609827 44 6708630 An antioxidant.
SGTC_1467 k284-1082 293 µM 1.69004875702882 0.0378042977600031 no 200 0.0455093135725324 75 3334705
SGTC_154 3389-1638 511.116 µM 1.68861280643627 0.0379297799916053 no 201 0.0456468274341406 73 5238686
SGTC_175 3793-3120 23.7 µM 1.68829722681963 0.0379574027886366 no 202 0.0456770936560961 71 5322297
SGTC_842 0271-0008 11.1 µM 1.68581485018356 0.0381752588894555 no 203 0.0459157332893881 89 1221709
SGTC_406 estrone 100 µM 1.68477908563743 0.0382664597250336 no 204 0.0460156007326172 67 5870 A steroid.
SGTC_1810 st050138 53 µM 1.68445419722821 0.0382951032791049 no 205 0.0460469620946816 88 3444541
SGTC_2722 naftopidil 47.16 µM 1.68056982112476 0.0386389223456849 no 206 0.0464232508993503 70 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2894 9048625 32.47 µM 1.67990445732573 0.0386980674609468 no 207 0.0464879532178639 98 4092861
SGTC_2592 piperlongumine 83.33 µM 1.67885630270584 0.0387913889828411 no 208 0.0465900262656555 80 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2651 TUB2.036 5 µM 1.67856899255895 0.038817001374374 no 209 0.0466180369404411 105 15992207 YFL037W TUB2
SGTC_2490 carminic acid 95.39 µM 1.67486016188504 0.039148864919758 no 210 0.0469808357880737 75 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3303 9125618 40.5795 µM 1.67316700819336 0.039301133060201 no 211 0.0471472115904366 66 22695467
SGTC_2643 anethole 100 µM 1.67056835042276 0.0395357718291592 no 212 0.0474034841469459 87 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_878 0828-0289 13.7 µM 1.66841468732663 0.0397310933338972 no 213 0.0476167173215494 92 745350 YLR208W SEC13
SGTC_838 0109-0203 71.4 µM 1.6636260065727 0.0401682038741841 no 214 0.048093595706827 67 759422
SGTC_618 k072-0232 33.2 µM 1.66361812946759 0.0401689261013189 no 215 0.0480943832813651 90 5872756 YGL099W LSG1
SGTC_753 1322-0200 289 µM 1.65940577239362 0.0405566577599842 no 216 0.0485170269495302 60 5403907
SGTC_3194 9111903 49.47 µM 1.65931790701237 0.0405647776711228 no 217 0.0485258743748693 73 17087251
SGTC_2491 paeonol 100 µM 1.65431552522679 0.0410292438036113 no 218 0.0490317100713169 61 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1416 3966-0321 25.3 µM 1.65370444949354 0.0410862760181785 no 219 0.0490937890780413 83 582530 YLR208W SEC13
SGTC_1645 Cervolide 78 µM 1.65340993399695 0.0411137863479898 no 220 0.0491237312344753 82 23173 A fragrance.
SGTC_2875 9039966 71.43 µM 1.64907659306121 0.041520287696581 no 221 0.0495659721371176 62 6463691
SGTC_3038 9091290 49.47 µM 1.64880579663228 0.0415457982534261 no 222 0.0495937135207949 66 25236843
SGTC_2684 capsaicin 100 µM 1.64879608030385 0.0415467138225257 no 223 0.0495947091274871 82 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1399 3562-5772 25 µM 1.64839940558435 0.0415841064189508 no 224 0.0496353689652264 78 23847490
SGTC_2220 6782180 200 µM 1.64629336380967 0.0417830896170457 no 225 0.0498516875512768 38 833803
SGTC_2325 6158266 200 µM 1.64497472991434 0.0419080689396709 no 226 0.0499875112123076 74 3623240
SGTC_2435 5706476 10.6 µM 1.64467221196535 0.0419367840498031 no 227 0.0500187131425371 70 5725375
SGTC_2610 ononetin 44.17 µM 1.64087248766307 0.0422988135081482 no 228 0.0504119435753569 84 259632
SGTC_1081 sertraline 6 µM 1.6401819768064 0.0423648745883893 no 229 0.0504836677888478 78 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_801 0866-0028 10.1 µM 1.62618044871742 0.0437224940335935 no 230 0.051955637026416 92 6849771
SGTC_3215 9129942 49.47 µM 1.61013933180173 0.0453207915231657 no 231 0.0536837211236844 90 17682944
SGTC_1260 0700-1617 7.75 µM 1.60763209465976 0.0455748012520048 no 232 0.0539578893682929 90 2853078
SGTC_1522 st012842 45.6 µM 1.60267123492638 0.0460807614853929 no 233 0.054503628722178 93 3491067 YOR116C RPO31
SGTC_608 k048-0125 159 µM 1.60014259717113 0.0463403889695633 no 234 0.0547834765065967 81 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3103 9120822 49.47 µM 1.59966260070412 0.0463898049057394 no 235 0.0548367264138155 114 17141819
SGTC_3312 9133330 71.43 µM 1.59837778751293 0.046522285411989 no 236 0.0549794625027939 85 17617324
SGTC_1694 st024011 44.9 µM 1.59503139790304 0.0468687662653539 no 237 0.0553526073695038 90 2787533
SGTC_162 k030-0015 37.8 µM 1.5918719747181 0.0471977854131432 no 238 0.0557067368895768 85 1809920 YMR134W ERG29
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.58713804635177 0.0476942345033433 no 239 0.056240691299773 111 368090
SGTC_784 4579-0127 173 µM 1.58641786849221 0.0477701250329125 no 240 0.0563222748429745 91 1948547
SGTC_1301 naphtanilide LB 4.81 µM 1.58527885260905 0.0478903490224972 no 241 0.0564514958208381 103 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2010 4012422 159 µM 1.58471198986444 0.0479502720208241 no 242 0.0565158932328271 89 952393
SGTC_1469 k284-2957 126 µM 1.58176363248419 0.0482629110621353 no 243 0.0568517700587153 96 23884841
SGTC_396 dithiazanine 1.25 µM 1.5706041366929 0.0494610391337866 no 244 0.0581373142525704 69 10578 An antihelmenthic.
SGTC_1454 4239-0054 42.6 µM 1.56750680539522 0.0497977568638459 no 245 0.0584981383820104 91 1340767
SGTC_3248 9135562 49.47 µM 1.56567827593734 0.0499973971790306 no 246 0.0587119772809902 85 17650701
SGTC_1529 apigenin 74 µM 1.56458285812144 0.050117301144237 no 247 0.0588403754113205 91 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2999 9069765 71.4286 µM 1.56328704694666 0.0502594359557955 no 248 0.0589925468038301 78 2097066
SGTC_1107 amlodipine 47 µM 1.56243622990166 0.0503529348976774 no 249 0.0590926288565849 81 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2101 5377231 179.231 µM 1.56141656643545 0.0504651714460549 no 250 0.0592127477954662 102 2844213
SGTC_1320 1313-0481 95.3 µM 1.56012482058373 0.0506076427865115 no 251 0.0593651935681083 63 6813365 YLR208W SEC13
SGTC_275 trichlorophene 5.69 µM 1.55976130985183 0.0506477934173848 no 252 0.0594081488282258 74 62616
SGTC_395 anisomycin 6.25 µM 1.55702883822819 0.0509504141561596 no 253 0.0597318193670846 84 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2937 9044753 11.33 µM 1.55441351846657 0.0512414067559803 no 254 0.0600429053442831 89 6465530 YGL099W LSG1
SGTC_3323 9138564 53.9225 µM 1.54922002776505 0.0518231776048784 no 255 0.060664418285271 102 43912313 YNL103W MET4
SGTC_858 0438-0351 2.77 µM 1.54648666089507 0.05213146898897 no 256 0.0609935395693888 94 2799119
SGTC_683 panaxydol 45 µM 1.5464452241829 0.0521361537438481 no 257 0.0609985396311591 62 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_533 1222-0222 6.71 µM 1.54511153792893 0.0522871164110699 no 258 0.0611596433179428 102 3982874
SGTC_124 0136-0217 7.121 µM 1.54032683063881 0.0528315654077977 no 259 0.0617403534219902 126 3976905
SGTC_2670 beta-carotene 100 µM 1.53905684342424 0.0529768292159167 no 260 0.0618952098155857 49 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3343 9148379 18.9835 µM 1.53772261740369 0.0531297818146748 no 261 0.0620582255505485 73 1955036
SGTC_3224 9130643 49.47 µM 1.52378546783848 0.054748515705123 no 262 0.0637811554542053 86 17644395
SGTC_2857 9024691 58.44 µM 1.51935113447965 0.0552716399955098 no 263 0.0643370674865573 106 16478292
SGTC_1704 st028805 70.8 µM 1.51711664058356 0.0555367379921777 no 264 0.064618618797083 98 2876101
SGTC_2787 5284540 71.43 µM 1.50184648131182 0.0573753328265778 no 265 0.0665683804709915 101 736958
SGTC_1184 1269-1718 139 µM 1.49977501716525 0.0576283933768611 no 266 0.0668363454218595 101 5403821
SGTC_1141 3253-0389 52.6 µM 1.49793059615027 0.0578544551841403 no 267 0.0670756417066996 107 5402031
SGTC_1451 4152-0210 104 µM 1.4963243217248 0.0580518959057399 no 268 0.0672845800167451 98 659563
SGTC_1001 4048-4355 44.4 µM 1.49381771157671 0.0583610618990419 no 269 0.0676116354569624 116 21824233
SGTC_1116 jasmonic acid 1.58368 µM 1.4876012758925 0.059133379682781 no 270 0.0684280383852556 89 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2046 4110841 106 µM 1.48561463451867 0.0593818792229217 no 271 0.0686905409361176 115 44119630 YMR134W ERG29
SGTC_2834 9001755 58.44 µM 1.48467600645089 0.0594995721789915 no 272 0.0688148352815729 100 2989575
SGTC_3 0833-0587 95.581 µM 1.47958465682546 0.060141156243739 no 273 0.0694920618119667 103 5382644
SGTC_2825 7998094 58.44 µM 1.47701663506605 0.060466812816517 no 274 0.0698355890934809 109 2987815
SGTC_512 prima-1 270 µM 1.47435064247227 0.0608063513593787 no 275 0.0701936032172135 87 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_417 st075190 100 µM 1.46913037940693 0.0614755157677085 no 276 0.0708987146142157 110 222757
SGTC_427 1354-0053 47.3 µM 1.46812849379613 0.0616045988501779 no 277 0.071034661521025 78 6813657
SGTC_1247 0448-0043 5.84 µM 1.46804965965361 0.0616147648275325 no 278 0.0710453670986854 110 3089013 YGL099W LSG1
SGTC_1974 st069448 26.9 µM 1.46782657703572 0.0616435393199181 no 279 0.0710756681526488 91 6323587 YNR016C ACC1
SGTC_3109 9122853 49.47 µM 1.45858253703609 0.0628451402961571 no 280 0.0723400214458983 117 1234709
SGTC_773 4358-1457 44.6 µM 1.45633293875367 0.0631403010674975 no 281 0.0726503020656693 131 1186886
SGTC_1010 4112-3296 15.2 µM 1.45589085167003 0.0631984322603982 no 282 0.0727113975180771 74 704384
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.45443173762593 0.0633905907929591 no 283 0.0729133230712062 87 17037758
SGTC_2320 7373003 200 µM 1.45233142578778 0.0636679902104456 no 284 0.073204736730466 105 5415828
SGTC_771 0250-0039 27.3 µM 1.45054936137859 0.0639040968281805 no 285 0.0734526923450945 117 3005115
SGTC_1157 4092-0394 27.6 µM 1.44967527561967 0.0640201535259933 no 286 0.073574546774042 94 3659885
SGTC_974 1326-0144 138 µM 1.43763174745044 0.0656359676916068 no 287 0.0752692840381435 109 5411856
SGTC_931 2812-0076 566 µM 1.43178620571726 0.0664315447440313 no 288 0.0761025081124277 108 3450959
SGTC_861 0443-0273 110 µM 1.43125430892719 0.0665043047852591 no 289 0.076178671877264 115 6149169
SGTC_1760 st045453 10.4495 µM 1.42659879020029 0.0671437852718232 no 290 0.0768477865693132 115 3323419 YIL048W NEO1
SGTC_325 2810-4341 181 µM 1.42526446183288 0.0673279420997914 no 291 0.0770403844298701 91 774970
SGTC_394 menadione 8.33 µM 1.42422224763045 0.0674720542933854 no 292 0.0771910733333458 115 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1679 SEC14.276 6.7 µM 1.42228421605514 0.0677406693139708 no 293 0.0774718795557262 136 1005053 YMR079W SEC14
SGTC_2582 agaric acid 100 µM 1.42039197744415 0.0680037336156571 no 294 0.0777467985488372 137 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_442 cape 100 µM 1.41907199574852 0.0681877076933267 no 295 0.0779390136824244 92 5281787
SGTC_1928 4'-methoxychalcone 40.3 µM 1.41821771461343 0.0683069787934504 no 296 0.0780636057850632 123 641818
SGTC_745 0469-0705 296 µM 1.41641011437122 0.0685598789070379 no 297 0.0783277321515503 149 3486736
SGTC_1418 3966-3099 2.4 µM 1.41616263441896 0.0685945597952998 no 298 0.0783639465758209 128 740335
SGTC_2623 humulene 100 µM 1.41220608304771 0.0691508548279414 no 299 0.0789446449529759 86 6187145 An anti-inflammatory.
SGTC_738 1315-0003 72.4 µM 1.41162115861949 0.0692333899017301 no 300 0.0790307694682332 122 6251474
SGTC_2339 9000433 200 µM 1.41153247047971 0.069245910760811 no 301 0.0790438341570982 94 2988954
SGTC_2057 5236571 38.335 µM 1.41033715595978 0.0694148337275506 no 302 0.0792200760827129 105 54684039 YBR257W POP4
SGTC_932 2857-0803 154 µM 1.40852833288764 0.0696710615971127 no 303 0.0794873416898268 110 674898
SGTC_1619 st003326 88.7 µM 1.40758473936351 0.0698050145066453 no 304 0.0796270344419731 81 2849032
SGTC_1021 4476-0760 85.3 µM 1.40270834726101 0.0705004303260611 no 305 0.0803519135767674 96 746768
SGTC_1861 st057647 17.4 µM 1.39812048239523 0.0711595504071703 no 306 0.0810384450479468 110 688668
SGTC_1472 k841-0093 193 µM 1.39808496311441 0.0711646717138372 no 307 0.0810437773951967 98 X1472
SGTC_770 0389-1121 67.2 µM 1.39674590389425 0.0713579489441504 no 308 0.0812449974608113 109 6753108
SGTC_975 1335-0046 28.5 µM 1.39631355388382 0.0714204394843864 no 309 0.0813100470117678 98 16486740
SGTC_2196 6573537 42.6665 µM 1.39612086924227 0.0714483030562546 no 310 0.0813390501804308 118 2903087
SGTC_809 3998-0021 90 µM 1.39495663182406 0.0716168376021463 no 311 0.0815144589178966 122 715485
SGTC_1017 4239-0030 168 µM 1.39403286620395 0.0717507784263881 no 312 0.0816538400417831 109 1149593
SGTC_2179 6298986 200 µM 1.39149277835369 0.0721200674709027 no 313 0.0820380240116335 108 738374
SGTC_2249 haloperidol 116.36 µM 1.38988759839344 0.0723541857046533 no 314 0.0822815060367796 153 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1797 st048695 56.8 µM 1.38462925921332 0.0731252028455925 no 315 0.0830829299751046 113 592262 YIL048W NEO1
SGTC_563 tetrahydrosecaminediol 614 µM 1.3840692074863 0.0732076909017919 no 316 0.0831686322378184 95 334274 A psychoactive constituent of the cannabis plant.
SGTC_2170 morpholine 200 µM 1.38391487916262 0.0732304338868074 no 317 0.0831922601039702 99 121171 Reacts with secondary amines.
SGTC_2311 7694451 200 µM 1.38374144397655 0.0732559990534136 no 318 0.083218819278371 146 2163142
SGTC_2087 5276107 200 µM 1.37915365114058 0.0739347432997343 no 319 0.0839236924751466 104 144405
SGTC_210 3551-0445 56.827 µM 1.37840783900393 0.0740455356406498 no 320 0.0840387022423694 104 2865180 YOR207C RET1
SGTC_1733 st037357 54.9 µM 1.37702297690234 0.074251596883491 no 321 0.084252572062747 133 1272339 YGL099W LSG1
SGTC_1410 3909-8106 77.9 µM 1.37604876945674 0.0743968167633056 no 322 0.0844032674145677 131 1039210
SGTC_444 curcumin 90.4 µM 1.37215669601322 0.0749791516905686 no 323 0.0850073314316303 122 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_85 0868-0259 160.055 µM 1.37001045736098 0.0753017572628457 no 324 0.0853418186519409 106 83173
SGTC_1560 lithocholic acid 53.1 µM 1.36459029985732 0.0761211818403018 no 325 0.0861909276161057 95 9903 A bile acid which acts as a detergent.
SGTC_311 1315-0136 58 µM 1.3619248832752 0.0765266235162768 no 326 0.0866107961848794 103 6759207
SGTC_830 4076-0286 57.8 µM 1.36143534607127 0.0766012661952014 no 327 0.0866880762143317 121 6866659
SGTC_1027 k015-0025 8.67 µM 1.35731894266897 0.0772311109740785 no 328 0.0873399454973178 124 3598955
SGTC_2037 5169046 200 µM 1.35711390722018 0.0772625857093238 no 329 0.0873725101081465 123 5718022
SGTC_1695 st026914 34.495 µM 1.35654750807254 0.0773495835755002 no 330 0.0874625151537425 109 3289191
SGTC_207 4185-0010 4.486 µM 1.35225348938604 0.0780115589861841 no 331 0.0881471188207898 127 3761753
SGTC_487 nimodipine 119 µM 1.35161045566622 0.0781110594225823 no 332 0.0882499818835752 80 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1023 4482-3888 16 µM 1.34998954015927 0.0783623004966282 no 333 0.0885096690333059 132 3303168
SGTC_1043 0916-0009 19.3 µM 1.34908157969185 0.0785033013961305 no 334 0.0886553820751509 128 3101130
SGTC_1243 0416-0003 5.65 µM 1.34791004659428 0.0786855176425052 no 335 0.0888436581830449 108 2141977
SGTC_2027 5150920 200 µM 1.34708512866424 0.0788140147306688 no 336 0.0889764085624602 98 786715
SGTC_2594 a-mangostin 100 µM 1.34309339124111 0.07943805277341 no 337 0.0896208676267813 130 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2112 5488546 200 µM 1.34273143558185 0.0794948225811035 no 338 0.0896794759260459 124 600757
SGTC_259 usnic acid 108.925 µM 1.34101736968417 0.0797640769217443 no 339 0.0899574065848252 134 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2085 5307070 144.047 µM 1.33998239645259 0.0799269895563493 no 340 0.090125534043824 135 2840351
SGTC_2308 7584454 197.62 µM 1.33270818826938 0.0810791112490785 no 341 0.0913137925504685 126 893577
SGTC_97 0535-0701 19.132 µM 1.32858246348012 0.0817381083600428 no 342 0.0919928804078668 120 2832013 YGL099W LSG1
SGTC_788 1182-0090 188 µM 1.32578179596998 0.0821877510340326 no 343 0.0924559922465462 123 5715185
SGTC_3229 9132204 49.47 µM 1.32549798876853 0.0822334195868217 no 344 0.0925030180305308 89 17682924
SGTC_1447 4239-0816 81.9 µM 1.32493749316843 0.0823236673183828 no 345 0.0925959420197503 137 1341554
SGTC_205 1486-1330 71.903 µM 1.32436949571516 0.0824151990223233 no 346 0.0926901801587069 112 4118834
SGTC_837 0091-0265 12.5 µM 1.32151814387308 0.082875847053745 no 347 0.0931643284089953 135 759367
SGTC_23 0213-0011 39.996 µM 1.31959666292573 0.0831873612254048 no 348 0.0934848588167475 127 627608
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.31674730016996 0.0836509250508397 no 349 0.0939616714844825 89 4000243
SGTC_1042 0350-0096 82 µM 1.31665543296481 0.0836659031891863 no 350 0.0939770743618604 122 3122515
SGTC_22 0964-0034 14.468 µM 1.31449560702002 0.0840186245708204 no 351 0.0943397377326254 154 138402
SGTC_547 1120-0019 610 nM 1.30927593722868 0.084875657329566 no 352 0.0952204487594791 114 3676939
SGTC_2991 9074669 71.4286 µM 1.3057374649084 0.0854603660735718 no 353 0.0958209263455315 169 17333109
SGTC_1908 st060353 56.5 µM 1.3026445452481 0.0859739166771437 no 354 0.0963480712411355 144 4227716
SGTC_1087 pterostilbene 9.05 µM 1.30168839420455 0.0861331430436233 no 355 0.096511464288507 141 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.30152669628138 0.0861600921447079 no 356 0.0965391163502075 125 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1897 st060201 15 µM 1.30151774538989 0.086161584113573 no 357 0.0965406472176888 121 611878
SGTC_3238 9133470 49.47 µM 1.30021162555911 0.086379500389058 no 358 0.0967642235999416 104 3534688
SGTC_1865 st057639 52.2 µM 1.2945279011285 0.0873325874913795 no 359 0.0977415691178101 137 688818
SGTC_2064 5220758 200 µM 1.29330200921025 0.0875391790667316 no 360 0.0979533130140895 144 788518
SGTC_1896 st058441 89 µM 1.29296056660288 0.0875967850480029 no 361 0.0980123489776833 121 688759
SGTC_3076 9116187 49.47 µM 1.29225950059243 0.0877151530132142 no 362 0.0981336461106489 106 27241210
SGTC_3033 9090887 49.47 µM 1.29167804172758 0.0878134170037723 no 363 0.0982343324418956 137 19325384
SGTC_1318 1280-3875 124 µM 1.2893168943209 0.0882132843054327 no 364 0.0986439699872586 150 373245
SGTC_2541 muurolladie-3-one 83.07 µM 1.28887464279811 0.0882883315860946 no 365 0.0987208354224602 174 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2800 7887935 81.82 µM 1.28550413124546 0.0888618499247529 no 366 0.0993080870098064 126 2961002
SGTC_2355 9061122 103.12 µM 1.28266844709616 0.0893465080225171 no 367 0.0998041294037495 132 5302957
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.28256711480019 0.0893638634484209 no 368 0.099821888759411 147 442882
SGTC_2327 6189656 200 µM 1.2819921503841 0.0894623864734452 no 369 0.0999226999232042 115 5349088
SGTC_2910 7948405 25.97 µM 1.28064718259085 0.0896931689129392 no 370 0.100158809691671 103 2971328
SGTC_2182 6325192 200 µM 1.27304095052412 0.091006654041702 no 371 0.10150175544044 126 736248
SGTC_2151 5563267 85.4165 µM 1.27219488275292 0.0911536348426613 no 372 0.101651942678378 145 5310824
SGTC_3320 9137005 35.139 µM 1.27209977569996 0.0911701680545957 no 373 0.101668835439325 148 4908713
SGTC_1731 st035964 63 µM 1.26962238253778 0.0916016166668379 no 374 0.102109586322431 138 6739575
SGTC_2715 st079500 56.4 µM 1.26264934072081 0.0928241215601701 no 375 0.103357613721147 139 28246688
SGTC_3113 9123498 49.47 µM 1.262348741892 0.0928770921111123 no 376 0.103411662455929 140 8897275
SGTC_2958 9077254 16.72 µM 1.26230844786494 0.0928841942922811 no 377 0.103418909023889 113 16457351
SGTC_2275 7947463 200 µM 1.26177514303536 0.0929782318484799 no 378 0.103514854483473 135 1225414
SGTC_1649 st011737 51.3 µM 1.26025257647448 0.0932470930312173 no 379 0.103789130857766 121 1761035
SGTC_492 tmb-8 126 µM 1.25942551171266 0.0933933801514192 no 380 0.103938339748641 114 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3042 9091578 49.47 µM 1.25878530059735 0.093506733876459 no 381 0.104053945563269 118 25236497
SGTC_929 2805-0021 398 µM 1.2583398635303 0.0935856614551388 no 382 0.104134435129054 150 3098024
SGTC_1646 st011709 75.6 µM 1.25509719957372 0.094161716483252 no 383 0.104721738479076 140 5757843
SGTC_724 3910-0327 137 µM 1.25426368929711 0.0943102102235767 no 384 0.104873088625992 144 2885483
SGTC_1602 st001878 87.6 µM 1.25397181732752 0.0943622493818954 no 385 0.104926124632188 151 595405 YLR310C CDC25
SGTC_3232 9132874 49.47 µM 1.25285379576624 0.094561782358547 no 386 0.105129459782382 126 3784940
SGTC_282 k297-0036 65.7 µM 1.25144677256053 0.0948133351860482 no 387 0.105385760875048 130 5061378
SGTC_2796 7949634 45.45 µM 1.25056109815049 0.0949719320258744 no 388 0.105547325539591 141 2971588
SGTC_1692 fluoroquinolonic acid 71 µM 1.24929595800799 0.0951988182610803 no 389 0.105778422882874 129 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1973 st070275 50.2 µM 1.24572467566855 0.0958414339473649 no 390 0.106432745662221 100 17118334
SGTC_2502 avocadyne acetate 18.59 µM 1.2445951634132 0.0960453407771703 no 391 0.106640299563166 122 3952079
SGTC_185 k048-0037 25.491 µM 1.24185907872142 0.0965405983000635 no 392 0.107144280292841 111 6827589
SGTC_1203 3992-3522 103 µM 1.23893156614918 0.0970725809990334 no 393 0.107685421237537 144 5322312
SGTC_699 0375-0592 111 µM 1.23706009733228 0.0974137867043064 no 394 0.108032386119439 113 762578
SGTC_3350 9150499 3.57 µM 1.23186026198249 0.098366435856099 no 395 0.109000643876702 138 4910996 YPR165W RHO1
SGTC_2353 9059630 146.67 µM 1.23112743136528 0.098501242609839 no 396 0.109137603686653 130 4779114
SGTC_1483 3453-0561 55.9 µM 1.23051196379018 0.098614564484649 no 397 0.109252724850755 149 4546991
SGTC_1270 0831-1170 17.3 µM 1.22561597380885 0.0995194306595006 no 398 0.110171611888815 154 6764716
SGTC_3162 9099653 49.47 µM 1.22508718402741 0.0996175223418881 no 399 0.110271186695829 111 25237511
SGTC_1718 roemerine 11.9335 µM 1.22071850833092 0.100430625475182 no 400 0.111096308793949 154 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1169 aniline yellow 25.8 µM 1.22050370348662 0.100470729754556 no 401 0.111136993231385 142 6051 A DNA damaging agent.
SGTC_2079 5212404 121 µM 1.21895428451752 0.100760353989011 no 402 0.111430772114808 120 758462
SGTC_201 4262-0159 12.803 µM 1.2181969899077 0.100902132154389 no 403 0.111574561632135 125 1341029
SGTC_2329 6138490 200 µM 1.21787273322322 0.100962882858274 no 404 0.111636169676054 137 720019
SGTC_2513 baicalein 25.65 µM 1.2162881566695 0.101260142766821 no 405 0.111937585746619 149 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_601 0986-0029 62.9 µM 1.21395757484889 0.101698508063175 no 406 0.112381962616749 140 24747981
SGTC_817 1391-0715 46 µM 1.21184708158512 0.102096666993509 no 407 0.112785461007221 167 1353946
SGTC_954 1189-0853 2.85 µM 1.21134656362589 0.102191259272012 no 408 0.112881304973903 137 2828194
SGTC_1949 st076024 69.1 µM 1.20840828490968 0.102747846852935 no 409 0.113445127290836 155 2921930
SGTC_1581 himbacine 57.9 µM 1.20636310119367 0.103136556923083 no 410 0.11383875845599 133 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_79 0052-0007 94.094 µM 1.20530473318787 0.103338130444715 no 411 0.114042841533485 140 2801472
SGTC_1380 2291-0730 164 µM 1.19259968792461 0.105780249512128 no 412 0.116513094070131 141 2999191
SGTC_2814 7977482 42.97 µM 1.19209104239328 0.105878880801786 no 413 0.11661277447416 155 6456762
SGTC_2369 9071472 200 µM 1.18901255672855 0.106477247683393 no 414 0.117217362892143 116 17296037
SGTC_2318 6029776 164 µM 1.18817098445407 0.106641248661941 no 415 0.117383026318502 144 818325
SGTC_679 0422-0091 41.4 µM 1.1881432031227 0.106646665642035 no 416 0.117388497896674 157 627384 YHR062C RPP1
SGTC_1756 st041558 35.5 µM 1.18725869479763 0.106819236515908 no 417 0.117562797666826 148 3955792
SGTC_897 1000-0139 31.4 µM 1.18200653016263 0.107848104787069 no 418 0.118601554889274 146 6151020
SGTC_774 k060-0086 136 µM 1.18144700726894 0.107958131305436 no 419 0.118712596703938 150 5911235
SGTC_925 2064-1272 59.6 µM 1.18121455606898 0.108003865071911 no 420 0.118758750101129 152 6815817
SGTC_2689 tacrolimus 100 µM 1.17399826287424 0.10943058474658 no 421 0.120197860711792 144 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_328 k915-0120 63.5 µM 1.17358407524703 0.109512881835455 no 422 0.120280831424965 119 6624543
SGTC_1271 0832-2808 169 µM 1.1727993686286 0.109668921116522 no 423 0.120438135699117 163 3663794
SGTC_2108 5365811 200 µM 1.17011731502668 0.110203453718777 no 424 0.120976880668883 138 780283
SGTC_1319 1306-0155 43.7 µM 1.16934990951047 0.110356740710179 no 425 0.121131341181202 154 3122360
SGTC_3166 9102297 49.47 µM 1.16899226866809 0.110428230620065 no 426 0.121203373162149 148 25237072
SGTC_3353 9151644 39.2805 µM 1.16840414561898 0.110545864501568 no 427 0.121321891762777 146 4909158
SGTC_805 3852-0218 479 µM 1.1672440336423 0.110778168475494 no 428 0.121555916481675 141 6615355
SGTC_3040 9091894 49.47 µM 1.16659204003048 0.110908878877562 no 429 0.121687579713028 128 25236966
SGTC_1700 st030840 7.9285 µM 1.16645539761237 0.110936286679881 no 430 0.121715185905174 171 5499307
SGTC_232 clozapine 119 µM 1.16481181449656 0.11126633758421 no 431 0.122047587752217 139 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_592 k241-0073 46.5 µM 1.16296829994429 0.111637372855237 no 432 0.12242118210697 156 4230158
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.1628146193347 0.111668343333908 no 433 0.122452362194747 147 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2642 cholecalciferol 100 µM 1.16210485037757 0.111811459242393 no 434 0.122596438731147 127 9821465 A vitamin D precursor, similar to steriods.
SGTC_2858 9025781 8.96 µM 1.16072827895059 0.11208940125173 no 435 0.122876208913695 157 4894980 YPL153C RAD53
SGTC_1111 tnp00062 510.699 nM 1.15975400781808 0.112286413511443 no 436 0.123074487166256 143 676306
SGTC_184 1494-0393 24.714 µM 1.15931875269608 0.112374508558967 no 437 0.123163140311166 181 3090647
SGTC_551 k048-0028 34.9 µM 1.15653375538632 0.112939357259254 no 438 0.123731450375914 172 6836383
SGTC_143 4032-1194 15.74 µM 1.15492677755898 0.113266202513066 no 439 0.124060206379962 169 1806963
SGTC_2475 5812728 15.03 µM 1.15218641613316 0.11382512349761 no 440 0.124622239205782 147 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1613 st002381 52.1 µM 1.15020975389669 0.114229499645467 no 441 0.125028744912012 148 551167
SGTC_1229 0139-0193 12.2 µM 1.14997165882119 0.114278276953864 no 442 0.125077772208879 158 3090752
SGTC_475 α-linolenic acid 10 µM 1.14962168058986 0.114350002107329 no 443 0.125149862273438 152 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_791 1348-1292 225 µM 1.14339373104682 0.115631732390436 no 444 0.126437577064425 157 5437054
SGTC_47 0149-0135 24.25 µM 1.14157535025359 0.116007878093076 no 445 0.126815287461271 161 5239155
SGTC_182 3448-4371 550.524 µM 1.1386577795653 0.116613212948653 no 446 0.127422959468913 131 3491403
SGTC_2156 5649887 115 µM 1.13604081827248 0.117158080317332 no 447 0.127969740792508 161 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2717 st081029 62.2815 µM 1.13404877312011 0.117574043570083 no 448 0.128387044918578 143 5292846
SGTC_2255 7941087 197.44 µM 1.13363664956027 0.117660230343356 no 449 0.128473496545286 144 935561
SGTC_2221 6807166 181.081 µM 1.13080515255769 0.118253586160315 no 450 0.129068555392497 127 674925
SGTC_3249 9135183 49.47 µM 1.13054173097398 0.118308894985618 no 451 0.129124012283505 149 4902779
SGTC_2840 9008771 71.43 µM 1.12498915663454 0.119478988791254 no 452 0.130296814606724 103 2992978
SGTC_1606 st000094 49.2 µM 1.12316214677776 0.119865773743344 no 453 0.130684317927887 160 1242210
SGTC_2022 5136654 200 µM 1.12314519120886 0.119869367431419 no 454 0.13068791788061 179 1713771
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.12230577249569 0.12004737498693 no 455 0.13086622632152 178 65057 A dermal irritant. YDR527W RBA50
SGTC_2844 9010103 25.97 µM 1.11912561663259 0.120723450084481 no 456 0.131543276391494 163 2480525
SGTC_1332 1480-0653 17.5 µM 1.11904182008762 0.120741300712966 no 457 0.131561149174614 154 5749438
SGTC_1786 berberine 21.6 µM 1.11820380932499 0.120919918852378 no 458 0.13173997886758 172 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2886 9058944 51.95 µM 1.11413491493402 0.121789827958752 no 459 0.132610655986919 99 4949929
SGTC_914 3820-6779 408 µM 1.11352802364926 0.121919954127768 no 460 0.13274085978129 134 2893481
SGTC_3001 9076041 71.4286 µM 1.11196093016998 0.12225641294366 no 461 0.133077474581741 145 16004211
SGTC_1571 st070080 73.4 µM 1.11192949894234 0.122263167966612 no 462 0.13308423207699 145 4315245
SGTC_235 0330-0087 5 mM 1.11096958696725 0.122469593055415 no 463 0.133290720225843 152 46494818 YHR062C RPP1
SGTC_3192 9110362 49.47 µM 1.10805824968644 0.123097159329825 no 464 0.133918330117725 154 16649480
SGTC_1743 st037606 46.3785 µM 1.10802915032779 0.123103443328337 no 465 0.133924613429415 132 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1632 st005650 90 µM 1.10674377156985 0.123381244871825 no 466 0.134202362422313 146 2759605
SGTC_737 1950-0117 57.9 µM 1.10586590440442 0.123571225492388 no 467 0.134392282163227 157 5393513
SGTC_725 1497-0963 19 µM 1.10507427752382 0.123742718301391 no 468 0.134563702659758 153 3549977
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.10266114836183 0.124266510508623 no 469 0.135087172359102 185 6708760
SGTC_3245 9134821 49.47 µM 1.10251606789074 0.124298050925697 no 470 0.13511868848062 171 17014901
SGTC_398 bronopol 33.3 µM 1.10200905550194 0.12440831912081 no 471 0.135228867394074 186 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1475 4092-1048 11.7 µM 1.10125795051185 0.124571799786081 no 472 0.135392203279392 158 2881759
SGTC_2658 polymyxin b sulfate 77.05 µM 1.10103274173139 0.124620846527611 no 473 0.135441203696757 168 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2982 9019404 25.97 µM 1.10087363437791 0.124655505609266 no 474 0.135475829240197 134 22333232
SGTC_230 MPP+ 141.667 µM 1.09813818617856 0.125252434618061 no 475 0.136072076523232 157 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2450 5739737 12.93 µM 1.09659855389147 0.125589289317589 no 476 0.136408459966494 157 2262825
SGTC_1795 st049545 62.3 µM 1.09534305780299 0.125864445650808 no 477 0.136683185225318 135 5291882
SGTC_1444 4112-3581 28 µM 1.09466126033675 0.126014045396273 no 478 0.136832533239757 168 2877249
SGTC_766 1391-0721 126 µM 1.09407465929762 0.126142856360718 no 479 0.136961117676249 181 1020919 YIL115C NUP159
SGTC_921 1561-0023 372 µM 1.09407241496845 0.126143349366251 no 480 0.136961609797415 169 24050882
SGTC_1628 st004252 77.7 µM 1.09356829829852 0.126254121305477 no 481 0.137072179676592 155 692968
SGTC_72 0744-0168 198.391 µM 1.0922869385341 0.126535985642031 no 482 0.137353499785778 167 677577
SGTC_104 0074-0074 590.992 µM 1.09113586271264 0.126789564541536 no 483 0.137606552257981 151 3943124
SGTC_503 tyrphostin 8 294 µM 1.08898175706006 0.127265058341637 no 484 0.138080965283757 181 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_542 3381-0244 89.3 µM 1.08763500759658 0.127562967106482 no 485 0.138378134900635 173 1112843
SGTC_489 paxilline 115 µM 1.08513773456091 0.128116660672308 no 486 0.138930328368306 157 105008 A toxic potassium channel blocker.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.08326357824771 0.128533292227215 no 487 0.139345723350391 151 61125 An anti-inflammatory.
SGTC_2447 5741742 33.78 µM 1.08152678449939 0.128920226253492 no 488 0.139731426427453 174 1776504
SGTC_1841 st054148 70 µM 1.07365685728159 0.130683659304821 no 489 0.141488252179827 178 675442
SGTC_249 wiskostatin 11.211 µM 1.07340723268132 0.130739864813103 no 490 0.141544220405546 152 2775510 A n-wasp and actin depolymerizer.
SGTC_1231 0242-0792 125 µM 1.07329805140341 0.130764453336115 no 491 0.141568704608216 158 3707635
SGTC_507 nimesulide 162 µM 1.0713369011732 0.131206664952227 no 492 0.142008986655488 154 4495 A COX2 inhibitor.
SGTC_1854 st056233 32.9 µM 1.0710531041443 0.131270742610668 no 493 0.142072776333852 175 5393174
SGTC_2780 5215298 71.43 µM 1.06885309193266 0.131768209722498 no 494 0.142567935802748 192 2834131
SGTC_579 4491-1009 110 µM 1.06857279687375 0.131831683378737 no 495 0.142631105873102 190 1271041
SGTC_2164 5685496 200 µM 1.0674912474205 0.132076801202042 no 496 0.142875031956955 135 759046
SGTC_3093 9117344 49.47 µM 1.06711536793668 0.132162062492418 no 497 0.142959871510095 149 24824913
SGTC_1400 3771-8998 51.5 µM 1.06256871239482 0.133196393006591 no 498 0.143988791001148 135 670767
SGTC_901 1112-0062 60.1 µM 1.06230588337544 0.133256354510757 no 499 0.144048422185555 159 1908457
SGTC_3018 9082602 49.47 µM 1.05936402193596 0.133928774816261 no 500 0.144717014123821 179 17332089
SGTC_130 0136-0219 337.655 µM 1.05831086860574 0.134170059551939 no 501 0.144956869758197 192 234244
SGTC_803 4488-1585 147 µM 1.05278566614052 0.135440813183966 no 502 0.146219617926339 157 747204
SGTC_1819 st053448 58.6 µM 1.0520024285612 0.135621617026137 no 503 0.146399217705443 192 2857616
SGTC_3265 9137266 49.47 µM 1.04669238634997 0.136851755820516 no 504 0.147620738187399 129 17224265
SGTC_2929 9013348 24.6 µM 1.04580665637204 0.137057686260556 no 505 0.147825153665137 153 2995952
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.04496623758505 0.137253277601205 no 506 0.148019287032072 157 6708514
SGTC_3013 9080133 71.4286 µM 1.04464613469917 0.137327825514126 no 507 0.148093274368291 175 17050193
SGTC_2568 diosmetin 100 µM 1.04421462893018 0.137428361502448 no 508 0.148193050095194 203 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1219 1469-0211 33.1 µM 1.03962445225104 0.138500931674129 no 509 0.149257205984747 189 6822282
SGTC_2981 9013952 38.96 µM 1.03803118977426 0.138874553661174 no 510 0.149627767298222 172 2996344
SGTC_650 1328-0195 38 µM 1.03741301067812 0.139019702044758 no 511 0.149771708674056 186 2780821
SGTC_2724 maprotiline 69.64 µM 1.03561972705139 0.139441349030359 no 512 0.150189792533033 176 4011 A tricyclic antidepressant.
SGTC_2218 6965428 192.983 µM 1.03421283595422 0.13977275356671 no 513 0.150518337354416 161 675684
SGTC_3316 9136639 10.545 µM 1.03378201723691 0.139874343385975 no 514 0.150619040145923 181 4903665
SGTC_701 4424-0219 185 µM 1.03232145552592 0.140219126621619 no 515 0.150960776621915 176 2911779
SGTC_360 0957-0399 1.01 µM 1.02258816250154 0.142531524413407 no 516 0.153251304426803 175 6752301 YPR165W RHO1
SGTC_3210 9128157 49.47 µM 1.02126044737053 0.142848945385363 no 517 0.153565530160513 163 17590849
SGTC_1744 st037937 38.9 µM 1.02119745442466 0.142864017167046 no 518 0.153580449076417 178 1016152
SGTC_3177 9107506 49.47 µM 1.01582454943187 0.144153502219605 no 519 0.154856471694408 162 8897194
SGTC_60 0986-0278 202 µM 1.01524907166086 0.144292079391431 no 520 0.154993557159256 176 3110598
SGTC_379 3970-0972 5.9 µM 1.01348249771703 0.144718037685969 no 521 0.15541487597235 178 2898042 YBL034C STU1
SGTC_1900 st060200 72.8 µM 1.01308578694493 0.144813809362978 no 522 0.155509593263465 179 688945
SGTC_588 3970-1144 52.9 µM 1.01235128358044 0.144991241662569 no 523 0.155685061252533 144 1888707
SGTC_166 k072-0058 166.424 µM 1.00973081614258 0.145625454024539 no 524 0.156312137075525 190 5846229
SGTC_2544 sphondin 68.51 µM 1.00915897520591 0.145764100011076 no 525 0.156449199001528 187 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_196 k015-0023 18.111 µM 1.00691020398073 0.14631018731715 no 526 0.156988963983992 161 5211998
SGTC_1909 st060837 51.5 µM 1.00094688538686 0.147764952594613 no 527 0.158426243862847 184 678937
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.999723711000704 0.148064541847644 no 528 0.158722117016285 164 4174840
SGTC_279 1273-0055 2.93 µM 0.997894460236732 0.148513334025335 no 529 0.15916526927721 205 2847562
SGTC_2833 9001315 45.46 µM 0.992749267990478 0.149780539158344 no 530 0.160416079330606 176 2989378
SGTC_3207 9114163 49.47 µM 0.98987056698777 0.150492669547 no 531 0.16111869371676 203 849233
SGTC_4 0960-0234 25.671 µM 0.989532327125712 0.150576490841451 no 532 0.161201380707615 182 6821112
SGTC_863 0466-0191 129 µM 0.989218395536406 0.150654315972041 no 533 0.161278150002777 208 765160 YPR165W RHO1
SGTC_2826 7992541 19.48 µM 0.987524924839167 0.151074597316005 no 534 0.161692685066465 217 2985066
SGTC_2890 9046729 58.44 µM 0.985992568385658 0.151455565454675 no 535 0.162068379842346 184 903329
SGTC_2536 dehydroabietamide 32.04 µM 0.985019956818519 0.15169770323988 no 536 0.162307134135203 160 3983547
SGTC_994 3910-0338 138 µM 0.984920634923681 0.151722444522137 no 537 0.1623315283075 205 3479481
SGTC_2813 7971799 71.43 µM 0.984593486866984 0.151803956718773 no 538 0.162411895100893 183 2234054
SGTC_31 0508-1974 57.237 µM 0.980772947895535 0.152758035997266 no 539 0.16335236070552 174 6810525
SGTC_431 k089-0097 107 µM 0.980328817637125 0.15286920334188 no 540 0.163461917090038 204 5499420
SGTC_213 1246-0773 967 nM 0.980188776006416 0.152904267369657 no 541 0.163496471927473 166 6251622
SGTC_237 nikkomycin 200 µM 0.979136971533709 0.153167791638186 no 542 0.163756153018554 188 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_896 0964-0007 44.5 µM 0.979015542082908 0.15319823453922 no 543 0.16378615008977 184 6756758
SGTC_1208 2323-2347 50.3 µM 0.97807417418251 0.153434375665932 no 544 0.164018819935173 173 5412760
SGTC_1624 st003710 6.25 µM 0.974250522638989 0.154396011885772 no 545 0.164966082315277 185 24207033
SGTC_3150 9097574 49.47 µM 0.974013690248253 0.154455705244855 no 546 0.165024870886269 168 17217476
SGTC_1875 nocodazole 6 µM 0.972582608406091 0.154816732537252 no 547 0.16538039489738 195 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_350 k064-0020 19.8 µM 0.972161091934494 0.154923177131524 no 548 0.165485206744873 190 2790705
SGTC_1335 1486-0900 202 µM 0.968461533014519 0.155859491796979 no 549 0.166406960667363 186 X1335
SGTC_524 r073-0010 27.8 µM 0.968207625008495 0.155923889439213 no 550 0.166470343786009 200 2772106
SGTC_1982 st072467 71.9 µM 0.967782075120321 0.156031859232025 no 551 0.166576608856598 193 3163533
SGTC_204 PMA1.184 62.41 µM 0.967622886178064 0.15607226103984 no 552 0.166616371554494 201 2252213 YGL008C PMA1
SGTC_272 doxorubicin 8.13 µM 0.965420772129873 0.156631860059529 no 553 0.167167050707068 199 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2198 6589944 200 µM 0.964793954874163 0.156791387422757 no 554 0.167324012182227 162 5290268
SGTC_1450 4112-4260 37.6 µM 0.962274476125606 0.157433682542395 no 555 0.167955873331149 200 1633175
SGTC_3041 9091929 49.47 µM 0.961837893922617 0.157545156753394 no 556 0.168065519890421 179 25236887
SGTC_106 0092-0003 11.579 µM 0.961228510761786 0.157700839598533 no 557 0.168218641991566 175 1072148
SGTC_1652 st011932 78 µM 0.960801092591173 0.157810095013752 no 558 0.168326094567698 197 1551076
SGTC_1061 3448-9325 110 µM 0.960400923621206 0.157912430114487 no 559 0.168426736722199 214 723482
SGTC_3098 9119039 49.47 µM 0.960286685115334 0.157941652289844 no 560 0.168455474707437 181 17161528
SGTC_1161 k007-0610 110 µM 0.95870457627246 0.158346720326078 no 561 0.168853796209222 229 5843850
SGTC_3261 9137475 49.47 µM 0.95736673910675 0.158689778756592 no 562 0.169191090168709 125 17027690
SGTC_2973 9094665 17.96 µM 0.957088112579326 0.158761287565883 no 563 0.169261391558484 209 25237061 YIL048W NEO1
SGTC_3095 9117207 49.47 µM 0.956152354608028 0.159001602113677 no 564 0.169497633674252 151 17015229
SGTC_1067 clotrimazole 1.36 µM 0.954934601436624 0.15931469334094 no 565 0.169805385152736 201 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2874 9043904 71.43 µM 0.954494259609469 0.15942800703253 no 566 0.169916756818615 199 4463428
SGTC_2905 7799065 20.05 µM 0.953791324151916 0.159609003576565 no 567 0.17009464093538 187 1296806
SGTC_415 dibenzyl ketone 100 µM 0.952963097615816 0.159822433410582 no 568 0.170304384176719 201 7593
SGTC_1140 3229-1848 2.98 µM 0.952136486875262 0.160035632931747 no 569 0.170513883352775 195 2849525
SGTC_984 1492-0255 2.91 µM 0.951317938482182 0.160246936186948 no 570 0.170721501723773 192 1585198
SGTC_1362 1611-0397 101 µM 0.95119909179934 0.160277630884152 no 571 0.17075165969785 196 27816
SGTC_1113 artemisinin 1.17947 µM 0.950515311988381 0.160454306293407 no 572 0.170925238677118 226 2240 An anti-malaria and mitochondrial poison.
SGTC_128 0906-2981 13.371 µM 0.94981625616093 0.160635060216783 no 573 0.17110281216915 223 6740226
SGTC_589 1227-0070 34.1 µM 0.947671889388371 0.161190355591762 no 574 0.171648257928103 186 2841384
SGTC_763 3453-1109 128 µM 0.94693151483625 0.161382370085672 no 575 0.171836838889234 200 1560353
SGTC_2553 4-methylesculetin 85.09 µM 0.944778711001298 0.161941542101326 no 576 0.172385931369712 187 5319502
SGTC_49 0717-0965 32.132 µM 0.942017511323825 0.162660584984807 no 577 0.173091837284754 204 5889349 YGL099W LSG1
SGTC_1952 st077036 64.1 µM 0.938831943881765 0.163492713485448 no 578 0.173908517656682 183 2937007
SGTC_909 3448-9333 149 µM 0.938772930167108 0.163508154984272 no 579 0.17392367001717 178 3344074
SGTC_1965 Pectolinarigenin 58.4 µM 0.938558518265532 0.163564265865908 no 580 0.173978729479495 189 5320438 An anti-inflammatory.
SGTC_1340 1486-1359 257 µM 0.937305637558957 0.163892390541691 no 581 0.174300681944892 205 4309068
SGTC_365 0121-0052 13.6 µM 0.933366527827056 0.164926808968017 no 582 0.175315378222164 174 3101739
SGTC_2294 7971431 200 µM 0.932643973969367 0.165117011024809 no 583 0.175501910449633 204 5741572
SGTC_1837 st055472 66.5 µM 0.932135132515267 0.165251041495806 no 584 0.175633346813411 182 676091
SGTC_2017 5132927 60.65 µM 0.930789217630077 0.165605899113242 no 585 0.175981304136636 166 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1574 spiramycin 23.7 µM 0.930444047372426 0.165696984426056 no 586 0.176070610755408 221 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1688 st021091 57.6 µM 0.929532487220517 0.165937687334228 no 587 0.176306598519738 208 3656366
SGTC_2443 5493264 126.67 µM 0.925659010870431 0.166963020766172 no 588 0.177311607852929 213 5340055
SGTC_1202 1988-0068 29.6 µM 0.92474835126031 0.167204670059458 no 589 0.177548411124652 187 2850480
SGTC_747 3448-8087 38.7 µM 0.924568431529632 0.167252439558085 no 590 0.177595220134708 192 5168703
SGTC_3147 9097027 49.47 µM 0.924317237700949 0.167319147363385 no 591 0.177660585272571 234 25236841
SGTC_3202 9113761 49.47 µM 0.923606965010619 0.167507862339121 no 592 0.177845493095881 203 4798415
SGTC_1521 st012942 49.4 µM 0.923153500638476 0.167628416654418 no 593 0.177963608558502 190 24207259
SGTC_2396 5342950 42.78 µM 0.922745850703123 0.167736838806064 no 594 0.178069832786503 237 1886677
SGTC_256 clotrimazole 625 nM 0.920531642941228 0.168326537485892 no 595 0.178647502569165 189 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1063 disulfiram 1.84 µM 0.919704097196848 0.168547275419949 no 596 0.178863705486964 221 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.919290188308232 0.168657750452835 no 597 0.17897190424 226 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2525 harmine 47.85 µM 0.918582919206183 0.168846632962752 no 598 0.179156884753549 183 5280953 A monoamine oxidase inhibitor
SGTC_705 1124-0212 310 µM 0.918524594228656 0.168862215230958 no 599 0.17917214454558 238 9554485
SGTC_3146 9095609 49.47 µM 0.917692561229273 0.169084604146367 no 600 0.179389921606844 199 17173999
SGTC_1058 3448-5425 97.3 µM 0.917463447228978 0.169145875612293 no 601 0.17944991932118 219 7279705
SGTC_1504 k297-0033 30 µM 0.912072676372076 0.170591630748695 no 602 0.1808652304084 142 4388117
SGTC_739 1486-1183 203 µM 0.910712158260238 0.170957755865767 no 603 0.181223528126402 195 4346692
SGTC_1597 7-benzyloxygramine 47.5 µM 0.910061099715913 0.171133138067584 no 604 0.181395144075235 220 260807
SGTC_321 4534-3890 65.3 µM 0.90492254887517 0.172521397080014 no 605 0.182753210130035 213 699746
SGTC_1554 st069299 38.7 µM 0.904679239396063 0.172587308494371 no 606 0.182817671320658 192 24207999
SGTC_3348 9149464 3.537 µM 0.902594017873283 0.173152843702613 no 607 0.183370701309699 180 1951442
SGTC_306 1672-3436 11.6 µM 0.902142395848164 0.173275483925064 no 608 0.183490615076831 213 6797378
SGTC_781 4335-2806 94.4 µM 0.900492744232741 0.173723924926857 no 609 0.183929042447562 213 845254
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.899973942900971 0.173865108257534 no 610 0.184067058837765 202 88881 An O-methylated flavonoid and antioxidant.
SGTC_2008 4012253 172 µM 0.896362810659943 0.174849839780256 no 611 0.185029511408291 190 603940
SGTC_1919 st067113 52.3 µM 0.896154766247506 0.174906679730986 no 612 0.185085055277057 222 1268243
SGTC_1953 st076800 12.1 µM 0.895271376042467 0.175148161932593 no 613 0.185321018868307 211 297591
SGTC_3029 9088683 49.47 µM 0.894760322474219 0.175287959267403 no 614 0.185457612345433 201 25236615
SGTC_672 1441-0018 53.7 µM 0.887653702256619 0.177239284506847 no 615 0.187363528547647 200 251141
SGTC_814 3342-0569 96 µM 0.886760026478297 0.177485636093517 no 616 0.187604056544775 214 4346283
SGTC_1115 galangin 695.678 nM 0.884836864902147 0.178016509407918 no 617 0.188122311729434 232 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1323 1348-1351 11.2 µM 0.881332089154922 0.178986546409683 no 618 0.18906905132201 215 6989654
SGTC_462 ag-879 158 µM 0.880503598416294 0.179216337732393 no 619 0.189293278336223 238 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_246 cycloheximide 667 µM 0.878669489812658 0.179725708311823 no 620 0.18979025300605 216 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3278 9139605 49.47 µM 0.878010224959182 0.179909022058897 no 621 0.189969084925276 222 7958859
SGTC_2742 clothiapine 36.27 µM 0.877816466408233 0.179962920458475 no 622 0.190021663480769 172 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_179 1273-0063 6.77 µM 0.877574671440601 0.180030195513495 no 623 0.19008728980085 201 3108139
SGTC_2855 9016525 58.44 µM 0.877266770133301 0.180115886309279 no 624 0.190170878405772 219 43811474
SGTC_2277 7947813 106.88 µM 0.875373498944887 0.180643357748335 no 625 0.190685357202249 207 1246798
SGTC_1282 0886-0010 32.4 µM 0.874791614257051 0.180805667098674 no 626 0.190843650403949 218 2836211 YNL267W PIK1
SGTC_1156 4092-0367 4.88 µM 0.87236073344017 0.181484718693834 no 627 0.191505807404953 235 1357585
SGTC_2533 agelasine 13.65 µM 0.872255183379774 0.18151423957161 no 628 0.19153459044211 203 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_357 1325-0123 420 µM 0.871954189959541 0.181598439732894 no 629 0.19161668457726 229 1098503
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.87133669673548 0.181771254320128 no 630 0.191785169567779 234 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1792 st045773 43.6 µM 0.86825419180323 0.182635476656362 no 631 0.192627596682772 161 2919270
SGTC_478 N-arachidonylglycine 10 µM 0.866348359014192 0.183171084291903 no 632 0.193149577077804 172 5283389
SGTC_1821 st053465 65.6 µM 0.86595666181521 0.183281286560577 no 633 0.193256964221418 192 675086
SGTC_3074 9116018 49.47 µM 0.864861284938492 0.183589685399763 no 634 0.193557464557183 258 17027303
SGTC_2873 9040596 71.43 µM 0.863354128802218 0.184014547230491 no 635 0.19397139592377 231 6463863
SGTC_2659 sanguinarine 24.21 µM 0.860524804060364 0.184813775246265 no 636 0.194749908319871 220 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3126 9127922 49.47 µM 0.859396128827431 0.185133204699359 no 637 0.195061002381296 260 45595682
SGTC_1 0258-0098 57.368 µM 0.857804415452606 0.185584262253837 no 638 0.195500235605597 206 6790032 YDR047W HEM12
SGTC_2067 5224629 34.075 µM 0.857738895772749 0.185602843732412 no 639 0.195518328619897 212 2835000
SGTC_1426 4048-4480 71.7 µM 0.857591235835005 0.185644724542612 no 640 0.195559108086942 208 14224343
SGTC_1926 methyl fluorone black 53.6 µM 0.85655858013688 0.18593778069936 no 641 0.195844442498626 198 72721 Reacts with homocysteine.
SGTC_3252 9135871 49.47 µM 0.856025913077515 0.186089057745651 no 642 0.195991723131314 223 17682838
SGTC_2026 5148700 152 µM 0.854141844702236 0.186624743658045 no 643 0.196513200540273 220 79838
SGTC_2285 7945142 200 µM 0.852929003904339 0.186970088056736 no 644 0.196849338188574 220 2970608
SGTC_2208 7283366 200 µM 0.852277083276349 0.187155879267642 no 645 0.197030161125836 228 898663
SGTC_1907 st060210 83.7 µM 0.851671056750668 0.187328693460339 no 646 0.197198344569705 230 688793
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.851425061028387 0.187398869606277 no 647 0.197266637657951 235 688798
SGTC_2557 derrustone 83.84 µM 0.85108405514918 0.187496176537602 no 648 0.19736133103128 239 629853 An antioxidant.
SGTC_2584 androsterone 48.74 µM 0.850579298170173 0.187640267584795 no 649 0.197501546636692 215 2754130 A steroid.
SGTC_3176 9106582 49.47 µM 0.850151844688886 0.18776234458145 no 650 0.197620335318202 171 17018027
SGTC_1999 st074831 12.5 µM 0.849848093709775 0.187849123027117 no 651 0.197704773501663 226 17112523
SGTC_1838 st055369 84.5 µM 0.849651299688922 0.187905358218635 no 652 0.197759490903719 210 676036
SGTC_9 0092-0002 10.449 µM 0.849480257299347 0.187954243153914 no 653 0.197807055650761 234 759368
SGTC_1547 harmine 94.2 µM 0.847270561981954 0.188586493023099 no 654 0.198422165526453 214 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1757 st041620 31.8375 µM 0.845861258954329 0.188990414374701 no 655 0.198815073365245 211 5289815
SGTC_356 1634-0012 32.5 µM 0.84555104723695 0.189079395890721 no 656 0.198901622046146 243 735457
SGTC_107 0358-0022 2.6945 µM 0.844663280784656 0.189334186477882 no 657 0.199149433230383 216 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1390 3413-2614 145 µM 0.842420409886077 0.189978835362403 no 658 0.199776336315384 250 3421432
SGTC_318 1488-0629 67.2 µM 0.842374392264766 0.189992075916669 no 659 0.199789211080091 222 3662576
SGTC_2473 5854593 8.94 µM 0.842167055888616 0.190051739415028 no 660 0.199847225636979 226 2872951
SGTC_1025 k007-0731 70 µM 0.841331454318232 0.190292310366512 no 661 0.200081137049127 225 6256118
SGTC_2781 5567276 71.43 µM 0.839442327236206 0.190836882001253 no 662 0.200610569984246 227 2853274
SGTC_1770 st043884 66.3 µM 0.839166099063679 0.190916589320887 no 663 0.200688054097183 259 670149
SGTC_2457 5731572 11.68 µM 0.838583191128771 0.191084857959375 no 664 0.200851623173343 234 2865357
SGTC_2211 7117706 200 µM 0.837753364871145 0.191324561600425 no 665 0.201084617656968 211 822771
SGTC_3063 1327-0034 4 µM 0.837721347105267 0.191333813944439 no 666 0.201093610692611 238 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.837039832010747 0.191530820020851 no 667 0.201285089423191 202 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_844 0330-0132 15.3 µM 0.836674469169464 0.191636486879474 no 668 0.201387786891509 232 2828079
SGTC_682 0kpi-0099 17 µM 0.836486451646516 0.191690877479006 no 669 0.201440647752578 254 1714895 YML126C ERG13
SGTC_1641 st009299 47.1 µM 0.836063712891211 0.191813203868238 no 670 0.20155953051841 223 4046054
SGTC_3010 9080089 71.4286 µM 0.835622510443067 0.191940923987079 no 671 0.201683650469669 216 17027233
SGTC_2036 5160441 105 µM 0.835381224564425 0.192010793891701 no 672 0.201751548853336 240 134534 YIL048W NEO1
SGTC_1006 4099-6547 255 µM 0.834786634655962 0.192183037573174 no 673 0.201918926198615 238 3146833
SGTC_2994 9053520 71.4286 µM 0.833873865491363 0.192447636820587 no 674 0.202176032851354 203 4647384
SGTC_1297 1068-0111 14.1 µM 0.82821039578743 0.194094372354174 no 675 0.203775678712845 241 767057
SGTC_1218 1348-1416 30.7 µM 0.828199381267869 0.194097583325246 no 676 0.203778797094481 237 6787668
SGTC_2763 lisinopril 49.32 µM 0.828175192861224 0.194104634883366 no 677 0.203785645308079 237 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_584 0986-0246 15.4 µM 0.827775239730952 0.194221254386139 no 678 0.203898899791379 264 53315 YDR232W HEM1
SGTC_2142 5622915 118.518 µM 0.826424655575899 0.194615376901396 no 679 0.204281620983572 226 5322196
SGTC_811 0416-0114 265 µM 0.82464890692274 0.195134309311234 no 680 0.204785473362274 230 6612453
SGTC_1064 honokiol 6.76 µM 0.824216318412594 0.195260853242631 no 681 0.204908328245915 227 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2993 9054257 71.4286 µM 0.822270287361449 0.195830736826896 no 682 0.205461541670744 247 6470217 YGL055W OLE1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.822119282658769 0.195874999813435 no 683 0.205504506004077 199 6312947
SGTC_3028 9087778 49.47 µM 0.822109940202797 0.195877738503728 no 684 0.205507164324277 224 17217395
SGTC_1227 3909-8010 46.6 µM 0.820376965027291 0.196386152599646 no 685 0.2060006214548 202 15982272
SGTC_3136 9095672 49.47 µM 0.819607037507323 0.196612287580508 no 686 0.206220080229027 223 17217380
SGTC_2357 9067248 200 µM 0.819409108510708 0.196670446674381 no 687 0.206276519944673 227 9150235
SGTC_593 1203-0218 61.7 µM 0.818668548644361 0.196888143849957 no 688 0.206487772768674 232 3666956
SGTC_2442 5158906 48.48 µM 0.817787201112039 0.197147417433908 no 689 0.206739353780292 223 1893835
SGTC_1280 0880-0253 10.1 µM 0.816895561750663 0.197409928771015 no 690 0.206994057181668 237 6836607
SGTC_1346 1488-2224 62.4 µM 0.815447070090029 0.197836835725727 no 691 0.207408225181866 228 3722427
SGTC_2126 5251174 33.877 µM 0.815327482169157 0.197872106204385 no 692 0.207442440898935 222 790722
SGTC_1988 st071872 53.4 µM 0.814270471398063 0.198184019185725 no 693 0.207745010985251 211 16414116
SGTC_1228 0124-0032 52.5 µM 0.813673908736879 0.198360189637723 no 694 0.20791589249362 227 X1228
SGTC_651 3253-0966 34.4 µM 0.813274696287181 0.198478133515641 no 695 0.208030290651308 237 781462
SGTC_140 0062-0056 502.533 µM 0.813077909761953 0.198536287963238 no 696 0.208086695387457 217 3758964
SGTC_1393 3470-5649 58.2 µM 0.812317375836748 0.19876113791661 no 697 0.208304771348902 207 4108395
SGTC_308 4092-1169 104 µM 0.811724369855625 0.198936565134564 no 698 0.208474903755799 235 2268590 YDL196W YDL196W
SGTC_3231 9132313 49.47 µM 0.8105580534509 0.199281865223183 no 699 0.208809756914669 227 4905967
SGTC_1940 st075990 51.1 µM 0.809993159909165 0.199449237486954 no 700 0.208972053506406 246 1084979
SGTC_3282 9108498 15.4605 µM 0.808794521474933 0.199804662141267 no 701 0.209316674004108 237 16459645
SGTC_1794 st048918 76.9 µM 0.807064406422289 0.200318353486466 no 702 0.209814688708673 195 672303
SGTC_1276 0871-0068 94.2 µM 0.804990489349569 0.200935168207386 no 703 0.210412584026249 242 3414906
SGTC_440 fluspirilene 35.1 µM 0.803891529250278 0.201262477166339 no 704 0.210729811286929 236 3396 An atypical antipsychotic.
SGTC_2718 lomofungin 53.02 µM 0.798560731223049 0.202854706760751 no 705 0.212272582576109 240 5351222 A RNA synthesis inhibitor.
SGTC_2704 st078022 71.1 µM 0.798159786513728 0.202974766438485 no 706 0.21238888518 231 54697681
SGTC_2698 st077697 67.5 µM 0.795487822076038 0.203775947891714 no 707 0.213164896025287 245 3154499
SGTC_2291 7917025 104.35 µM 0.795215335935231 0.203857757931517 no 708 0.213244126194598 229 2964612
SGTC_262 fenpropimorph 62.5 µM 0.793338643029851 0.204421739438091 no 709 0.213790274116636 252 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1701 st028638 40.4 µM 0.789821584460476 0.205481179503474 no 710 0.214815985846963 229 3490878
SGTC_1237 0330-0133 46.1 µM 0.78960357901394 0.205546956201034 no 711 0.21487965871458 265 X1237 YHR072W ERG7
SGTC_2268 7933382 153.85 µM 0.788152001156646 0.205985245534729 no 712 0.215303900597441 234 935025 YOR257W CDC31
SGTC_1460 k062-0059 9.15 µM 0.787517543636643 0.206176987553259 no 713 0.215489481325802 224 1373085
SGTC_2053 5265679 138 µM 0.787216335611053 0.206268053899785 no 714 0.215577618046887 270 764595
SGTC_1388 3346-4487 254 µM 0.785008392325212 0.206936324542605 no 715 0.216224324046776 252 3345614
SGTC_2916 7875993 68.79 µM 0.78283925072559 0.207594097295261 no 716 0.21686075752729 268 1299250
SGTC_504 lovastatin 124 µM 0.782082115180385 0.207823982428386 no 717 0.217083158378669 241 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1881 5652484 16 µM 0.781189645198493 0.208095151421037 no 718 0.217345481494027 242 2255129
SGTC_828 2074-0507 139 µM 0.780130516064479 0.208417229118626 no 719 0.217657028006727 241 X828
SGTC_2290 7904846 200 µM 0.77980548230405 0.20851612974564 no 720 0.2177526894648 237 2962154
SGTC_1557 sumaresinolic acid 42.3 µM 0.777737940881073 0.209145884715237 no 721 0.218361760052965 233 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1708 st033234 31.827 µM 0.777530626515013 0.209209092565293 no 722 0.218422886232479 229 674664
SGTC_1739 st037196 92.5 µM 0.776692002237609 0.209464894530994 no 723 0.218670253276542 237 612214
SGTC_2850 9015429 58.44 µM 0.775647483514072 0.209783756788709 no 724 0.218978577906264 264 6457570
SGTC_1396 3511-0007 98.6 µM 0.775355284655945 0.209873007955567 no 725 0.219064874908287 240 X1396
SGTC_1796 st049173 110.4 µM 0.775007804182585 0.209979173754113 no 726 0.219167524043934 266 94134
SGTC_1102 cgs 12066b 26.1 µM 0.773814607663557 0.210343971556364 no 727 0.219520216419762 229 6438352 A 5-HT1B full agonist.
SGTC_2052 5265182 7.135 µM 0.772239676165532 0.210826047052666 no 728 0.219986243153554 239 1239884
SGTC_1759 st043059 70 µM 0.770797349444266 0.211268101047497 no 729 0.220413529287262 265 669426
SGTC_823 0417-1665 178 µM 0.769954944299649 0.211526538047976 no 730 0.22066330985886 251 3429856
SGTC_2114 5491910 81.25 µM 0.769145460064695 0.211775049720446 no 731 0.220903481778014 251 2849228
SGTC_639 0833-0042 114 µM 0.768639160018242 0.211930570650442 no 732 0.221053775757744 263 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1893 st059353 36.1 µM 0.768271403958727 0.212043576694729 no 733 0.221162979959577 259 3112488
SGTC_1782 st039423 80.636 µM 0.767832169989226 0.212178593018796 no 734 0.221293449777666 238 2068169
SGTC_599 1935-0052 86.5 µM 0.76618358129531 0.212685801547104 no 735 0.221783538158255 225 9557311
SGTC_305 1682-2595 20.8 µM 0.765626734070634 0.212857282245793 no 736 0.221949216304131 252 226033
SGTC_2611 pyromycin 23.93 µM 0.759695750216995 0.214688725397617 no 737 0.22371823481469 241 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2564 betulinic acid 100 µM 0.758374152213815 0.215098069023347 no 738 0.22411351359908 262 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_992 3909-8734 162 µM 0.756500669561096 0.215679125775721 no 739 0.224674535558241 245 4288319
SGTC_1856 st057054 55.7 µM 0.755864602326929 0.215876607444729 no 740 0.22486518943909 263 1266018
SGTC_2777 climbazole 1.536 µM 0.755816550252265 0.215891530569725 no 741 0.22487959622429 265 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1148 3909-7663 27.7 µM 0.755579530570339 0.215965148506518 no 742 0.224950666194341 254 4084526
SGTC_1403 3909-7815 62.9 µM 0.753991003987754 0.216458917580863 no 743 0.225427311780928 245 6615483
SGTC_1664 st014217 9.02 µM 0.752791673376056 0.216832143488027 no 744 0.225787555587546 255 3982782
SGTC_3034 9090421 49.47 µM 0.751833025654787 0.217130737412898 no 745 0.226075739304341 232 17173761
SGTC_1696 st025591 34.7925 µM 0.749949770011222 0.217718013977901 no 746 0.226642478791623 245 2787147
SGTC_2113 5491891 107.031 µM 0.749359919184959 0.217902142014763 no 747 0.226820150930511 259 789979
SGTC_2345 9052315 157.45 µM 0.746469408429901 0.218805742102017 no 748 0.227691952324323 250 6469265
SGTC_108 0509-0257 621.132 µM 0.746260597970831 0.218871101558911 no 749 0.227755004215263 247 536624
SGTC_1808 st050063 61.5 µM 0.744540386817402 0.219409969587682 no 750 0.228274808721252 259 4011993
SGTC_879 0831-1030 162 µM 0.743275433547921 0.219806710842924 no 751 0.228657470841388 257 1549252
SGTC_3124 9127567 49.47 µM 0.742482636016026 0.220055574461997 no 752 0.228897484226902 221 17592030
SGTC_646 4092-0839 27.3 µM 0.741321358006128 0.220420397808662 no 753 0.229249307352515 265 877796
SGTC_92 0063-0024 660.874 µM 0.74101414770863 0.220516967955533 no 754 0.229342431094461 254 3594437
SGTC_1132 3456-3614 2.5 µM 0.7404287570113 0.220701049931334 no 755 0.229519937519977 239 3125502
SGTC_3322 9139058 2.11 µM 0.739941686394348 0.220854281231617 no 756 0.229667689269555 235 4908926 YPR165W RHO1
SGTC_2411 st077133 39.94 µM 0.739829674677435 0.220889528473919 no 757 0.229701675298866 270 1403142 YNL221C POP1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.739584992845845 0.220966534831667 no 758 0.229775925220025 257 6710655
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.735144884593061 0.222366594311428 no 759 0.231125630588364 236 803109
SGTC_3141 9094609 49.47 µM 0.734922868533236 0.222436733227473 no 760 0.231193235036845 280 25236309 YDL196W YDL196W
SGTC_2215 7188065 200 µM 0.734836941946868 0.222463882387086 no 761 0.231219402859522 258 940217
SGTC_1381 2324-0066 62.1 µM 0.734127559857592 0.222688089250181 no 762 0.231435499056086 261 10885928
SGTC_581 0958-0271 211 µM 0.733233160032101 0.22297095618083 no 763 0.23170811688584 252 4591145
SGTC_2621 lithochol-11-enic acid 100 µM 0.732369545741438 0.223244280844726 no 764 0.231971520836339 259 6708711
SGTC_1269 0831-0796 3.05 µM 0.731589788837263 0.223491229292931 no 765 0.232209491296302 252 927758
SGTC_3283 9109332 35.8195 µM 0.731095896848341 0.223647724878195 no 766 0.232360290191994 233 17027281
SGTC_425 3825-7017 13.1 µM 0.730385198675772 0.223873027405283 no 767 0.232577381580796 256 3397440
SGTC_2181 6316240 54.2555 µM 0.729984607754617 0.224000077866528 no 768 0.232699796619418 261 12779990
SGTC_1720 st037298 9.481 µM 0.729771906472062 0.224067554344358 no 769 0.232764809738585 261 597396
SGTC_1764 st044502 93.5 µM 0.729423228729945 0.224178192406944 no 770 0.2328714065159 245 8407
SGTC_1440 4100-1550 40 µM 0.728967674492084 0.224322789917007 no 771 0.233010718128639 275 742806
SGTC_1267 0828-0272 9.49 µM 0.728740690005833 0.224394856840501 no 772 0.233080148814484 260 745334
SGTC_2060 5238662 140 µM 0.728613337654046 0.224435296601063 no 773 0.233119108758414 267 790130
SGTC_1302 1159-0335 255 µM 0.728568480404038 0.224449541660992 no 774 0.233132832459385 252 649284
SGTC_1412 3909-8563 178 µM 0.727517077911085 0.224783576452084 no 775 0.233454628702685 280 23767530
SGTC_333 3486-0131 40.1 µM 0.726624514536225 0.22506736850629 no 776 0.233728003298137 251 6744690
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.725726272846085 0.225353170838701 no 777 0.234003296102533 273 756377
SGTC_1732 st034308 51.822 µM 0.723783035882702 0.225972172165296 no 778 0.234599472824816 249 830119
SGTC_3117 9124945 49.47 µM 0.72363473810359 0.226019450585812 no 779 0.234645004419024 247 17592065
SGTC_2432 5630864 12.22 µM 0.723492059662503 0.226064942797496 no 780 0.234688815330411 272 5714970
SGTC_630 4356-0227 183 µM 0.72299298867189 0.226224109458309 no 781 0.234842095885995 278 779312
SGTC_361 000s-0510 1.45 µM 0.72293180090089 0.226243628179101 no 782 0.234860892401438 262 660
SGTC_1994 st072947 40.9 µM 0.722824747758556 0.226277780108254 no 783 0.234893780483188 277 5286565 YDL195W SEC31
SGTC_144 4161-2749 112.381 µM 0.722627809535372 0.226340614644159 no 784 0.234954289047916 267 797501 YMR168C CEP3
SGTC_2965 9082772 38.63 µM 0.721605292245585 0.226667014410978 no 785 0.235268592235786 202 16459634
SGTC_1101 ebselen 5.29 µM 0.720386208627201 0.22705650742733 no 786 0.235643619498539 267 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_385 1494-0393 12.4 µM 0.718702179658898 0.227595169038125 no 787 0.23616222002221 260 3090647
SGTC_1325 1431-0015 227 µM 0.718585673169807 0.227632461957429 no 788 0.236198121695057 243 1103340
SGTC_2778 tioconazole 65.09 nM 0.7181795585224 0.227762483333759 no 789 0.236323290113078 265 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_654 1124-0271 80.9 µM 0.717868431347716 0.227862121859537 no 790 0.236419207185248 259 5403748
SGTC_1588 farnesol 29.9 µM 0.717373984212935 0.228020519080006 no 791 0.23657168385542 261 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1355 1499-0035 1.68 µM 0.715176660529052 0.228725185186509 no 792 0.237249944463367 265 1548538
SGTC_3183 9108214 49.47 µM 0.711576346617455 0.229882418837733 no 793 0.238363579221995 252 4974831
SGTC_544 k015-0020 52.4 µM 0.711243352974213 0.229989616920499 no 794 0.238466723924165 271 3008304
SGTC_1579 chlormadinone acetate 49.4 µM 0.710724624957425 0.230156662762974 no 795 0.238627448475472 267 45114258 A steroidal progestin.
SGTC_3243 9134147 49.47 µM 0.710439669650631 0.230248455719105 no 796 0.238715765272894 275 24282180
SGTC_1461 k072-0203 53.8 µM 0.708694296242537 0.230811141280993 no 797 0.239257102568404 270 5418714
SGTC_183 3914-0051 30.55 µM 0.705324351659087 0.231899737115883 no 798 0.240304204662498 252 1596232
SGTC_3260 9137109 49.47 µM 0.704751582852624 0.232085042958897 no 799 0.240482422097266 251 17478346
SGTC_2342 7990637 118.86 µM 0.703909856202963 0.232357513284314 no 800 0.240744456522227 284 2033102 YER133W GLC7
SGTC_930 2810-3379 265 µM 0.703813502857767 0.232388714599016 no 801 0.240774461789683 288 1015764
SGTC_405 ebelactone b 50 µM 0.70318800331639 0.232591321653953 no 802 0.240969297248312 267 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2489 cantharidin 73.42 µM 0.702852565395214 0.23270001459463 no 803 0.241073817370517 265 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2407 paclitaxel 400 µM 0.701937415770745 0.232996696755886 no 804 0.241359096945313 291 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1995 st072814 61.1 µM 0.698080588934887 0.234249346009858 no 805 0.242563398325302 264 5769371
SGTC_1824 st053723 68.6 µM 0.696451765471389 0.234779485138548 no 806 0.243072977165336 274 675225
SGTC_626 0214-0009 33 µM 0.696296108963097 0.23483018192831 no 807 0.243121704728354 275 3437874
SGTC_2563 tomatine 8.54 µM 0.695826293719211 0.234983235825953 no 808 0.243268810282329 295 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3256 9138902 49.47 µM 0.69383202842319 0.235633530041564 no 809 0.243893777119857 298 17228773
SGTC_477 mead ethanolamide 10 µM 0.692464107993925 0.236080157741821 no 810 0.244322959189993 238 16061185
SGTC_2172 5754775 163.918 µM 0.69097617440166 0.23656649899774 no 811 0.244790256936516 264 2263357
SGTC_516 3992-2719 87.3 µM 0.689746194386258 0.236968942216475 no 812 0.245176905181471 261 5350887 YDR037W KRS1
SGTC_280 3448-3607 3.04 µM 0.689566819836308 0.237027664084488 no 813 0.245233319584271 250 626179
SGTC_2841 9004761 38.96 µM 0.688316812047426 0.237437101250611 no 814 0.245626648454204 245 2991039
SGTC_2219 9098279 200 µM 0.687971097619559 0.237550407717147 no 815 0.245735491129551 249 902349
SGTC_942 3253-1115 227 µM 0.687486566382764 0.237709260744219 no 816 0.245888081633715 303 46497897
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.686766867310418 0.237945320811517 no 817 0.246114825959021 273 5379071
SGTC_776 4476-4378 112 µM 0.686679609415288 0.23797394998542 no 818 0.24614232455943 306 2892008
SGTC_2223 6903751 107.57 µM 0.684810839943487 0.238587543290803 no 819 0.246731647069975 268 5598863
SGTC_1473 k844-0725 134 µM 0.684495542436068 0.238691153640053 no 820 0.246831151595878 283 54682906
SGTC_2312 7706453 155.7 µM 0.68369923426782 0.23895293914095 no 821 0.247082553555591 269 976098
SGTC_696 1560-0013 611 µM 0.683258107277247 0.239098026736186 no 822 0.247221880419326 268 1650269
SGTC_1941 st076221 61.8 µM 0.680257278555857 0.240086282348771 no 823 0.248170785013003 262 2828568
SGTC_43 0570-0105 72.5 µM 0.67872575999071 0.240591510585386 no 824 0.248655820520796 274 1114046 YDL195W SEC31
SGTC_2552 juarezic acid 87.02 µM 0.676670548775594 0.241270406829072 no 825 0.249307503281468 268 1549512
SGTC_3100 9120536 49.47 µM 0.676207366104376 0.241423553205921 no 826 0.249454498218602 275 16421196
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.675646884928846 0.241608940875611 no 827 0.249632433229622 285 2374 Ca(2+)-ATPase inhibitor.
SGTC_2593 nobiletin 86.24 µM 0.675147460208069 0.241774198293784 no 828 0.249791041534002 268 72344 An anti-infammatory.
SGTC_2691 st077356 60.2 µM 0.675094781506341 0.241791633017588 no 829 0.249807774460668 297 2839272
SGTC_3289 9119912 71.43 µM 0.674501642335878 0.241987987473584 no 830 0.24999622097173 290 17014829
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.674214589564275 0.242083045275979 no 831 0.250087447716002 289 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_625 k213-0058 121 µM 0.674068432251398 0.242131453189542 no 832 0.250133903993669 285 3655420
SGTC_1459 k035-0031 35.7 µM 0.672975439854271 0.242493623161719 no 833 0.250481458002009 272 3877128 YMR208W ERG12
SGTC_84 0443-0269 128.823 µM 0.671045650257875 0.243133786941242 no 834 0.251095724305962 265 6150058
SGTC_779 1360-0071 233 µM 0.669897398496172 0.243515126521183 no 835 0.25146159912906 280 7566
SGTC_2596 sinensetin 100 µM 0.669721028760408 0.243573728314212 no 836 0.251517821899209 292 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2911 7942208 15.64 µM 0.66944339835585 0.243665991086187 no 837 0.251606337785659 253 1243384
SGTC_1487 3970-0795 2.82 µM 0.669143561065673 0.24376565489178 no 838 0.251701952291681 276 3765103
SGTC_2382 9035899 200 µM 0.669116436638196 0.243774671945843 no 839 0.251710602891778 289 6462679
SGTC_2924 9010168 62.78 µM 0.668613932147139 0.243941753567022 no 840 0.251870891456583 282 2993929
SGTC_1650 st011916 45.8 µM 0.668298867702437 0.244046543297181 no 841 0.251971417988262 295 242528
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.667152313351541 0.244428089577972 no 842 0.252337423799663 279 2724 A muscle relaxant with antifungal properties.
SGTC_2746 daunorubicin 9.88 µM 0.666879923920325 0.244518781592253 no 843 0.252424417785554 253 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2625 euphol 100 µM 0.664965259425905 0.245156780026733 no 844 0.253036356795297 277 6708538 A triterpene alcohol.
SGTC_2918 7977171 22.06 µM 0.664765041738613 0.245223547591452 no 845 0.253100392693961 281 2236483
SGTC_1213 1315-0166 115 µM 0.663890879058892 0.245515173359846 no 846 0.25338007717665 271 768401
SGTC_3240 9133527 49.47 µM 0.662533063580004 0.245968517735147 no 847 0.253814826147537 296 17617455
SGTC_1190 1486-1332 13 µM 0.661056403092343 0.246462051218867 no 848 0.254288071358764 289 4150046
SGTC_1414 3917-0015 5.4 µM 0.66045817096319 0.246662144915603 no 849 0.254479926423669 288 6618702
SGTC_471 1-acyl-paf 4 µM 0.660177885934369 0.246755923174005 no 850 0.254569840864531 268 16759367
SGTC_1520 flindersine 88 µM 0.659107714070243 0.247114158680385 no 851 0.2549133012103 291 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1860 st056228 74.6 µM 0.658183591194547 0.247423728591928 no 852 0.255210083679627 311 688679
SGTC_2899 9053889 58.44 µM 0.65755508253607 0.247634389694874 no 853 0.255412032687571 277 6470052
SGTC_796 1234-0020 70.7 µM 0.656835879147534 0.247875566991838 no 854 0.255643225650509 276 46495034
SGTC_369 0957-0393 4.5 µM 0.656756419965184 0.247902220482442 no 855 0.255668775063356 287 6997992
SGTC_1238 0333-0287 48.8 µM 0.655114781388295 0.248453227676867 no 856 0.256196927950601 285 7226
SGTC_632 0781-2353 4.65 µM 0.654861101625597 0.248538432113131 no 857 0.25627859328092 299 6811515 YHR007C ERG11
SGTC_947 3447-0010 211 µM 0.654732475975331 0.248581640071895 no 858 0.256320006009978 296 748350
SGTC_135 0933-0004 26.348 µM 0.653233928285578 0.249085327316485 no 859 0.256802740170653 278 21230617 YGL099W LSG1
SGTC_3102 9121669 49.47 µM 0.652581604332943 0.249304753931377 no 860 0.257013024061589 297 41905072
SGTC_1516 st013856 110 µM 0.652549606103389 0.249315520035598 no 861 0.257023341351366 282 5281404 A mutagen and neurotoxin.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.652243632186185 0.249418480308606 no 862 0.257122008361885 284 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2251 lansoprazole 556 µM 0.652015573745107 0.249495236708148 no 863 0.257195562879876 296 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1424 4048-1941 275 µM 0.650841269750464 0.249890664499767 no 864 0.25757447823604 290 X1424
SGTC_710 3448-4187 58 µM 0.650734916078347 0.249926493792044 no 865 0.257608809930534 272 3946412
SGTC_2418 pentamidine 31.67 µM 0.649001854289452 0.250510725783759 no 866 0.25816858882746 271 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2077 5212015 200 µM 0.648891698368893 0.250547884861097 no 867 0.258204190489704 282 780900
SGTC_3206 9114350 49.47 µM 0.64806151422576 0.250828026152699 no 868 0.258472582337441 273 17087243
SGTC_2588 indole-3-carbinol 100 µM 0.646955396095191 0.25120153742804 no 869 0.258830405828345 286 3712 Induces cell cycle arrest.
SGTC_1575 cyproterone acetate 48 µM 0.646275444390053 0.251431287764206 no 870 0.259050493831021 303 9880 An androgen receptor antagonist and liver toxin.
SGTC_1138 3761-0006 1.03 µM 0.646104326932659 0.251489124494092 no 871 0.259105896678334 282 12061087
SGTC_386 1509-0011 3.07 µM 0.64592214730937 0.25155070789912 no 872 0.25916488786512 278 3107280
SGTC_403 arphamenine a 50 µM 0.645427836882109 0.251717843111046 no 873 0.259324984416321 287 5487158 An arginine aminopeptidase inhibitor.
SGTC_1980 st071811 45.7 µM 0.643408161787152 0.252401340282483 no 874 0.259979644419571 304 4974850
SGTC_2770 toltrazuril 17.5 µM 0.642763138885355 0.252619834435729 no 875 0.26018890236981 266 68591 Kills coccidiodes.
SGTC_3061 glucosamine 200 µM 0.641931933879232 0.252901542502099 no 876 0.260458689363038 274 91431 and experimental redox chemotherapeutic
SGTC_458 nppb 133 µM 0.639951683732892 0.253573345109844 no 877 0.261102005730867 286 4549 A chloride channel blocker.
SGTC_38 0929-0051 58.268 µM 0.639672577280591 0.253668107682237 no 878 0.261192743613744 299 1379719
SGTC_1691 st019933 84.6 µM 0.638299485190017 0.254134572308674 no 879 0.261639373529306 314 6176082
SGTC_1490 4089-0339 670 nM 0.637519547635527 0.254399731644865 no 880 0.261893240662966 297 742542
SGTC_1545 lovastatin 49.4 µM 0.636228581520733 0.254838946379902 no 881 0.262313723339685 276 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2639 lactacystin 53 µM 0.634380189439197 0.25546849985998 no 882 0.26291636752341 282 3870 A proteasome inhibitor.
SGTC_502 l-744,832 89.3 µM 0.634035563206628 0.255585967716007 no 883 0.263028806663078 312 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1555 citronellol 128 µM 0.633654563360486 0.255715866558107 no 884 0.263153141801915 291 8842 A terpine precursor.
SGTC_835 0312-0010 67.2 µM 0.633526521674431 0.255759529081656 no 885 0.263194933548162 301 1626196
SGTC_609 0986-0026 86.3 µM 0.633096973037369 0.25590603462716 no 886 0.263335159428534 282 2848610
SGTC_1368 1852-0141 284 µM 0.632698045940058 0.256042135339402 no 887 0.263465423084675 308 2838987
SGTC_1548 st061468 90.8 µM 0.632526394702214 0.256100708672743 no 888 0.263521483339243 292 390799
SGTC_435 c-PAF 6.7 µM 0.632415343026604 0.256138607064435 no 889 0.263557755386824 285 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1077 5-fluorocytosine 377 nM 0.632084005654918 0.256251699310382 no 890 0.263665992979694 314 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1040 k898-0338 155 µM 0.630841788897496 0.256675925015866 no 891 0.264071988247129 305 20969351
SGTC_2551 apiole 73.87 µM 0.630568229048905 0.256769396724347 no 892 0.26416143893353 282 10659 A possible DNA adduct former.
SGTC_950 1165-0508 94.1 µM 0.630546619713556 0.256776781097653 no 893 0.264168505576555 296 6148369
SGTC_2640 pentamidine 10.38 µM 0.629070185862412 0.257281571879501 no 894 0.264651554045762 292 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2629 bisabolol 100 µM 0.627906581255569 0.257679769897481 no 895 0.265032569712478 316 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_376 3970-0862 59.1 µM 0.627386546720292 0.257857834709566 no 896 0.265202942103831 312 3135186
SGTC_3164 9100705 49.47 µM 0.626700951878667 0.258092686499871 no 897 0.265427639898933 265 17174235
SGTC_3004 9076122 71.4286 µM 0.626582997993451 0.258133103003273 no 898 0.265466308005049 310 44782551
SGTC_612 0302-0167 22.4 µM 0.624030714074771 0.25900843759073 no 899 0.266303707173924 319 235821
SGTC_3218 9131285 49.47 µM 0.622825023421947 0.259422476054878 no 900 0.266699756242294 310 17156417
SGTC_2803 7707263 71.43 µM 0.620858297362953 0.260098589739601 no 901 0.267346430940299 296 2199229
SGTC_1505 k297-0037 20.6 µM 0.62054240174777 0.260207271757778 no 902 0.267450373540911 287 4089396
SGTC_2401 5128683 200 µM 0.617250749727844 0.26134113607918 no 903 0.26853467316954 310 708373
SGTC_2678 equilin 100 µM 0.615408815093318 0.261976726720613 no 904 0.269142385669869 272 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_408 cantharidin 100 µM 0.612914990927449 0.262838523945437 no 905 0.269966275240536 285 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_223 busulfan 5 mM 0.611943985293904 0.263174468561488 no 906 0.270287409334261 288 2478 A DNA alkylator.
SGTC_3060 1327-0027 12.5 µM 0.60861566910939 0.264327648228003 no 907 0.271389607996999 275 16000455 YPR107C YTH1
SGTC_870 0573-2213 57.6 µM 0.608411874417853 0.264398341565629 no 908 0.271457168938899 284 3916321
SGTC_2127 5253358 187.912 µM 0.607059131901358 0.264867831581419 no 909 0.271905835282846 304 20612
SGTC_33 0986-0033 35.816 µM 0.607022960646093 0.264880391184092 no 910 0.271917837324831 276 2848082
SGTC_2469 5655019 90.81 µM 0.606889655549711 0.26492668080163 no 911 0.271962071776953 307 2788239
SGTC_3181 9108277 49.47 µM 0.606557919116002 0.265041892684094 no 912 0.272072166968152 322 17097298
SGTC_129 0088-0017 176.636 µM 0.606078032587001 0.265208602045347 no 913 0.272231468748806 296 182446
SGTC_913 3487-1245 167 µM 0.605420792704871 0.265437009136988 no 914 0.272449719437269 282 4016153
SGTC_1640 st009078 66.4 µM 0.605255051826253 0.265494623941279 no 915 0.272504770989669 303 690618
SGTC_1604 st002052 72.4 µM 0.60500153419809 0.265582763950857 no 916 0.272588988654835 288 6254834 YHR062C RPP1
SGTC_1009 4106-0057 9.87 µM 0.601755717583615 0.266712540898068 no 917 0.273668377801514 297 2928005
SGTC_3284 9108171 64.8615 µM 0.601242850665945 0.266891277359583 no 918 0.273839123816037 298 8687505
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.59988963223201 0.267363170449711 no 919 0.274289896223393 289 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2344 7990960 76.95 µM 0.598165387101854 0.267965056856444 no 920 0.274864792155446 308 140813
SGTC_2374 9071832 200 µM 0.597380216954586 0.268239364003657 no 921 0.275126779377366 293 17381698
SGTC_2675 theaflavin digallate 100 µM 0.597012926358669 0.268367729178751 no 922 0.275249375198775 294 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3233 9132340 49.47 µM 0.596936620626223 0.268394401307603 no 923 0.275274848224877 339 17682950
SGTC_2741 miltefosine 3.04 µM 0.596790003964318 0.26844565386559 no 924 0.275323796297706 292 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2768 sulfasalazine 50.2 µM 0.596120092828117 0.268679896251025 no 925 0.275547501072616 316 5384001 An antioxidant and salicylic acid derivative.
SGTC_818 4072-2707 53.5 µM 0.59573490965379 0.268814626608136 no 926 0.275676166528183 310 882871
SGTC_481 bay k-8644 50 µM 0.593252274544407 0.269683822419681 no 927 0.276506166614169 326 2303 A calcium channel antagonist.
SGTC_2106 5357045 167.29 µM 0.593162198494344 0.269715385406809 no 928 0.276536304057647 307 668842
SGTC_602 3130-1533 38.1 µM 0.593064042544458 0.269749781727687 no 929 0.276569146689364 324 720941
SGTC_468 gf-109203x 121 µM 0.592055448918852 0.27010334558456 no 930 0.276906729249405 279 2396 A protein kinase C inhibitor.
SGTC_1562 morin hydrate 59.1 µM 0.591242992218941 0.2703883218663 no 931 0.277178810209437 309 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1275 0867-0008 21.1 µM 0.590551313452879 0.270631052604474 no 932 0.277410547269738 302 3422836
SGTC_307 1501-1223 22.3 µM 0.59029130180407 0.270722326594366 no 933 0.277497684935911 306 2830329
SGTC_561 1550-0330 72.9 µM 0.58898439578398 0.271181333028929 no 934 0.277935870652062 316 6812934
SGTC_652 0437-0092 114 µM 0.588483365201972 0.271357405870907 no 935 0.278103948089459 291 3091274
SGTC_1721 st082152 9.2685 µM 0.587025160405064 0.27187017411771 no 936 0.278593404416792 317 5296051
SGTC_2877 9040724 71.43 µM 0.586546774773213 0.27203850027376 no 937 0.278754069142249 302 6463895
SGTC_1404 3909-7820 48.3 µM 0.585434629532058 0.272430023097273 no 938 0.279127754801335 301 23741373
SGTC_3047 9092122 49.47 µM 0.583141760210894 0.273238093656982 no 939 0.279898936695928 311 17173831
SGTC_2519 cryptotanshinone 88.04 µM 0.582460165924913 0.27347853507984 no 940 0.280128382663181 297 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_133 0724-0033 378.92 µM 0.582181498244517 0.273576868955159 no 941 0.280222217168706 297 280309
SGTC_2324 6149169 200 µM 0.580356868847833 0.27422116065269 no 942 0.280836992335281 314 2888231
SGTC_1842 st055362 61.2 µM 0.580053229759975 0.274328450803175 no 943 0.280939361168149 296 676032
SGTC_2652 actinonin 100 µM 0.579780014407396 0.274425008509373 no 944 0.281031488359961 309 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1961 st076550 68.7 µM 0.579716116499381 0.274447593245359 no 945 0.281053036600753 317 1579337
SGTC_1273 0849-0096 14.1 µM 0.576886576295715 0.275448613803045 no 946 0.282008039643288 317 5286025
SGTC_2186 6124449 200 µM 0.576315387078922 0.275650903938094 no 947 0.282201012134152 306 3834182 YLR033W RSC58
SGTC_3189 9110682 49.47 µM 0.5759135353994 0.275793265909095 no 948 0.282336813135691 321 17122418
SGTC_764 1951-2361 146 µM 0.575681913197801 0.275875337951175 no 949 0.282415101388094 319 5438930
SGTC_2743 auranofin 4.32 µM 0.574801921844641 0.276187259753543 no 950 0.2827126334216 268 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1655 st012546 55.1 µM 0.573970603723393 0.276482087746726 no 951 0.282993846929961 325 720985 YLR208W SEC13
SGTC_1168 k815-0004 80.5 µM 0.570192201984332 0.277824043954546 no 952 0.284273672251084 334 642433
SGTC_1289 0976-0073 69.1 µM 0.568370776283346 0.278472084730226 no 953 0.284891614801118 331 3391136
SGTC_829 1635-0120 117 µM 0.567961290710428 0.278617875972119 no 954 0.285030626321891 322 285054
SGTC_1488 4013-0813 75.9 µM 0.566974787604541 0.278969258279545 no 955 0.285365655600025 301 2910057
SGTC_1395 3486-0190 4.35 µM 0.565623113043323 0.279451060662882 no 956 0.285825006167903 330 6748079
SGTC_3156 9099931 49.47 µM 0.563584111567562 0.280178623441755 no 957 0.286518601172717 323 18111053
SGTC_1876 myriocin 605 nM 0.562223946806891 0.280664471394316 no 958 0.286981723886733 347 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_10 0279-0212 42.575 µM 0.56177296159407 0.280825652272153 no 959 0.28713535815264 300 39851 YBR002C RER2
SGTC_2301 7769476 200 µM 0.560537864828441 0.281267301444898 no 960 0.287556309946441 312 977820
SGTC_2932 9016711 44.54 µM 0.559873019748878 0.281505177267905 no 961 0.287783026468556 332 7117328
SGTC_3188 9110789 49.47 µM 0.55889294765748 0.281856015476985 no 962 0.288117391367918 323 849217
SGTC_3328 9140624 29.0385 µM 0.558698351102671 0.281925700625633 no 963 0.288183802430149 312 4904392
SGTC_1864 st057645 30.4 µM 0.557216292145685 0.282456699017213 no 964 0.288689829823305 306 688666
SGTC_3352 9151559 45.5865 µM 0.556073981684399 0.282866298817127 no 965 0.289080140385609 297 17159339
SGTC_2265 7929201 200 µM 0.555853140309453 0.282945519099684 no 966 0.289155627231027 345 1265108
SGTC_1889 st059080 5.18 µM 0.555775040132663 0.282973537767483 no 967 0.289182325243826 302 176925 Isolated from Daphnopsis sellowiana.
SGTC_988 1497-1057 103 µM 0.55510159019416 0.283215195158668 no 968 0.289412587581032 343 3533044
SGTC_839 0122-0028 230 µM 0.555045751798354 0.283235236371622 no 969 0.289431683407587 338 759448
SGTC_2748 diazoxide 86.69 µM 0.554277414219492 0.28351107296882 no 970 0.289694502492738 289 3019 A potassium channel activatior.
SGTC_2950 9072895 21.46 µM 0.553328456485353 0.283851930589245 no 971 0.290019259377506 291 17332245
SGTC_151 3013-0144 2.285 µM 0.553230466773773 0.283887138838911 no 972 0.290052803607773 328 906558 YHR107C CDC12
SGTC_1917 st066507 28.5 µM 0.55252912187043 0.28413919697342 no 973 0.290292943875456 323 3156428
SGTC_2591 skatole 100 µM 0.550310989671173 0.284937080916483 no 974 0.291053043913951 340 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_918 glabranin 770.725 nM 0.548809351985622 0.285477840645957 no 975 0.291568145838292 321 124049 Also referred to as licorice root.
SGTC_1254 0550-0035 264 µM 0.548793094608019 0.285483697816719 no 976 0.291573724879235 331 15121435
SGTC_302 1094-0063 18.9 µM 0.547302685732228 0.286020901800577 no 977 0.292085399507652 322 5440289
SGTC_3062 9077494 49.47 µM 0.546912900778465 0.286161475359746 no 978 0.292219286108599 279 16459633
SGTC_2313 7726885 200 µM 0.545708809877297 0.28659593052377 no 979 0.292633057559911 304 726423
SGTC_539 4859-0462 2.54 µM 0.545499071830766 0.286671639331379 no 980 0.292705159358517 321 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_594 1487-1584 10.8 µM 0.544910285079613 0.286884223408741 no 981 0.292907611081209 330 5013332
SGTC_2481 5478948 45.16 µM 0.543411693813288 0.287425633209464 no 982 0.293423188049186 311 77792
SGTC_2815 7968870 71.43 µM 0.54328429208693 0.287471683078332 no 983 0.293467038861318 327 2977326 YHR190W ERG9
SGTC_2102 5377816 72.7585 µM 0.542379339012316 0.287798882392093 no 984 0.293778604908068 333 1379702
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.536867357118673 0.289795610979411 no 985 0.295679620260454 314 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1206 3978-0017 132 µM 0.536654970968925 0.289872678235319 no 986 0.295752982640496 334 3873677
SGTC_1785 bathophenanthroline 24 µM 0.535315744460836 0.290358856394628 no 987 0.29621577049673 316 72812 An iron chelator.
SGTC_278 4092-0821 23.9 µM 0.534551500912302 0.290636470029089 no 988 0.296480013983973 319 877900
SGTC_3105 9121040 49.47 µM 0.534510385163477 0.290651408960423 no 989 0.296494233153678 289 41448907
SGTC_526 4469-0568 170 µM 0.53372907703167 0.290935356465173 no 990 0.296764494411316 332 2901964
SGTC_3250 9135583 49.47 µM 0.533353306120245 0.29107196744631 no 991 0.296894516979995 310 7699353
SGTC_288 1315-0019 35.1 µM 0.533336284037334 0.291078156509691 no 992 0.296900407502048 335 6811474
SGTC_2854 9024559 71.43 µM 0.532069048891339 0.291539083376877 no 993 0.297339086577042 338 3163529
SGTC_3307 9126885 69.2785 µM 0.531629888898179 0.291698896835633 no 994 0.297491179752282 315 24824909
SGTC_1954 st077032 68.9 µM 0.531029836332002 0.291917326236248 no 995 0.29769905185634 344 698907
SGTC_2784 7567673 72.73 µM 0.530799110994975 0.292001334477909 no 996 0.297778998092593 335 3471247
SGTC_1250 0485-0349 40.2 µM 0.530703202555257 0.292036258528985 no 997 0.297812233209489 330 6842794 YDL195W SEC31
SGTC_83 0170-0301 39.027 µM 0.530358361826965 0.292161844720641 no 998 0.297931744716668 324 3089716
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.529803669913716 0.292363908498276 no 999 0.298124030239262 340 1273210
SGTC_89 0302-0250 142.109 µM 0.529662625863974 0.292415298539882 no 1000 0.298172932572671 336 4203518 YLR208W SEC13
SGTC_990 3985-0011 41.3 µM 0.527612442343322 0.293162765966018 no 1001 0.298884177682364 347 5399565 YGL099W LSG1
SGTC_169 k015-0017 16.025 µM 0.527181447252714 0.293320013208972 no 1002 0.299033795534645 366 1840002
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.525196348264787 0.294044774638643 no 1003 0.299723351615767 345 165506
SGTC_2373 9071805 200 µM 0.523507076420449 0.294662180496364 no 1004 0.300310713939044 339 10149009
SGTC_937 3122-0005 46.7 µM 0.523087272746003 0.294815705735835 no 1005 0.300456760963505 323 759535
SGTC_1852 st056254 31.4 µM 0.522332212199229 0.295091929604662 no 1006 0.300719522430894 332 442583
SGTC_538 2922-0838 53.3 µM 0.522007863786714 0.295210622600312 no 1007 0.300832427681256 307 777039
SGTC_1932 st074806 40.9 µM 0.521433111783888 0.295421002969888 no 1008 0.301032545036647 356 17251235
SGTC_2938 9059746 27.26 µM 0.521393604280891 0.295435466701825 no 1009 0.301046302976825 337 6471769
SGTC_1150 3909-7983 10.9 µM 0.520579926795556 0.29573342716225 no 1010 0.301329717881885 333 23965914
SGTC_1387 3342-1166 1.8 µM 0.520345405778641 0.295819332012885 no 1011 0.301411427031 325 3418228
SGTC_941 3237-0776 460 µM 0.519982203976162 0.295952395144194 no 1012 0.301537989356726 337 760008
SGTC_2521 angolensin 13.4 µM 0.519061805248366 0.296289716733677 no 1013 0.301858821112469 339 821428 A flavenoid.
SGTC_3032 9089427 49.47 µM 0.518856630998897 0.296364936108974 no 1014 0.301930361471039 317 17173707
SGTC_716 1683-5115 658 µM 0.518093443412923 0.296644806778599 no 1015 0.302196537305231 339 723597
SGTC_1910 st062352 60.4 µM 0.51795658217689 0.296695008345234 no 1016 0.302244281335861 324 2245730
SGTC_2939 9044578 71.43 µM 0.516114899005513 0.2973709274404 no 1017 0.302887081303961 350 2653634
SGTC_2620 irigenin 100 µM 0.515861085462855 0.297464135080603 no 1018 0.302975717435015 346 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2180 6301957 200 µM 0.515404262659334 0.297631927171717 no 1019 0.303135277193015 338 845462
SGTC_889 0919-1524 82.7 µM 0.515028670215973 0.297769915508428 no 1020 0.30326649283438 328 3905452
SGTC_1855 st056195 39.6 µM 0.51492246043643 0.297808941049981 no 1021 0.303303602510247 325 4028379
SGTC_2104 5389443 200 µM 0.514067991915683 0.298122990355006 no 1022 0.303602227460196 345 2244536
SGTC_997 3996-0078 137 µM 0.514065892096247 0.298123762303399 no 1023 0.303602961479769 330 735687
SGTC_2492 derrusnin 100 µM 0.512902158548618 0.298551721127636 no 1024 0.304009881719162 358 1715307 Part of coumarin class of compounds.
SGTC_3263 9137018 49.47 µM 0.510944342138725 0.299272330844058 no 1025 0.304695015210001 324 43844957
SGTC_2863 9028737 58.44 µM 0.507943324664805 0.300378438559544 no 1026 0.305746545022778 344 6460917
SGTC_2518 prenyletin 46.28 µM 0.50758752962583 0.300509699022761 no 1027 0.305871318939095 312 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3101 9120531 49.47 µM 0.507250882044192 0.300633919421508 no 1028 0.305989398774795 362 24824904
SGTC_2000 st075254 36.4 µM 0.506539353305775 0.300896544356063 no 1029 0.306239035292071 323 17234175
SGTC_1637 st007924 17.4 µM 0.506342519047044 0.300969214057571 no 1030 0.306308109562108 323 683336
SGTC_2766 oltipraz 83.91 µM 0.50415691390156 0.301776653888867 no 1031 0.307075557546365 324 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_585 0kpi-0023 191 µM 0.503893559323994 0.301874012083854 no 1032 0.307168088393633 333 64601
SGTC_2122 5258151 111.688 µM 0.502659649144047 0.302330357832639 no 1033 0.307601791912034 332 2173356
SGTC_283 0987-0079 11.7 µM 0.502428804666235 0.302415767035236 no 1034 0.307682960663805 339 411556
SGTC_11 0438-0307 1.3 µM 0.501928600882316 0.302600872498696 no 1035 0.307858872918433 352 4011476
SGTC_2431 5490079 200 µM 0.501598655896626 0.302722999759486 no 1036 0.307974932538428 363 5722345
SGTC_2463 5473429 200 µM 0.50119361628453 0.302872953050059 no 1037 0.308117433292154 355 5399405
SGTC_1241 0364-0022 50.8 µM 0.500231103773094 0.303229426636012 no 1038 0.308456179801999 351 4563895
SGTC_2415 st077333 57.7 µM 0.498229078893909 0.303971491438668 no 1039 0.309161294432698 384 2766255
SGTC_1433 4060-0023 7.6 µM 0.497683702616428 0.304173779285358 no 1040 0.309353498401904 323 3840627
SGTC_653 0203-0016 55.2 µM 0.497520715010702 0.304234245353297 no 1041 0.309410949357994 356 295302
SGTC_390 dec-rvkr-cmk 16.7 µM 0.497494410919685 0.304244004296152 no 1042 0.309420221635715 332 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1195 1502-0147 41.1 µM 0.496939481566146 0.304449918214501 no 1043 0.309615864314118 328 817940
SGTC_2096 5468907 200 µM 0.49589364513406 0.304838158227724 no 1044 0.309984724985345 331 759785
SGTC_78 0336-0123 156.75 µM 0.495697546227592 0.304910979417472 no 1045 0.310053909287265 324 6765896
SGTC_1079 idarubicin 2.36 µM 0.495360817994715 0.305036041234116 no 1046 0.310172723739632 368 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2963 9082507 9 µM 0.495111952008351 0.305128485400526 no 1047 0.310260548763554 343 16459611
SGTC_1530 rhein 70.4 µM 0.494080046884252 0.305511931188826 no 1048 0.310624824405717 339 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1567 st069303 68.4 µM 0.491959800280189 0.30630046344333 no 1049 0.311373881109069 357 5581319
SGTC_1036 k216-0215 33.5 µM 0.491041483612744 0.306642269772949 no 1050 0.311698553707267 314 622330
SGTC_2712 st079126 47.7 µM 0.48962092754603 0.307171345809025 no 1051 0.312201082394621 343 3152970
SGTC_1239 0337-0584 35.4 µM 0.488926528424355 0.307430116073142 no 1052 0.312446856774356 360 914301 YML130C ERO1
SGTC_296 1222-0039 74.9 µM 0.488008832390499 0.307772245788219 no 1053 0.312771792475676 318 5984176
SGTC_2298 7976326 193.81 µM 0.486894588351096 0.308187876064771 no 1054 0.313166517074976 325 2235818
SGTC_3071 9117417 49.47 µM 0.486455340417961 0.308351789995697 no 1055 0.313322180979019 346 45595590 YGL055W OLE1
SGTC_1212 0520-0165 585 µM 0.484971367013926 0.308905846106394 no 1056 0.313848328255814 372 5403258
SGTC_895 0964-0006 13.7 µM 0.483213942324299 0.309562560711645 no 1057 0.314471918374228 355 6738897
SGTC_155 k072-0202 43.6 µM 0.482690260762656 0.309758367856813 no 1058 0.314657839752083 369 5857737
SGTC_1742 st038235 28.8875 µM 0.480494944044331 0.310579794807366 no 1059 0.31543774871692 378 564103 YBR002C RER2
SGTC_2190 6049624 200 µM 0.480468044399199 0.310589865783163 no 1060 0.315447310204581 350 2265554
SGTC_2356 9061756 188.97 µM 0.47994495978641 0.310785731986844 no 1061 0.315633265361016 345 20104043
SGTC_420 mitomycin C 81.9 mM 0.478609876338189 0.311285889794348 no 1062 0.316108095465255 334 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2352 9027995 87.8 µM 0.476861805229384 0.311941290731353 no 1063 0.316730265757635 350 2997347
SGTC_1152 3909-8331 15.9 µM 0.476577776898094 0.312047837255626 no 1064 0.316831405644378 371 16001939
SGTC_2002 4023503 131 µM 0.475111460419024 0.312598141272605 no 1065 0.317353765163832 386 4736863 YCR052W RSC6
SGTC_337 1315-0038 354 µM 0.474854995414049 0.312694434782034 no 1066 0.317445165499752 369 1626437
SGTC_2433 5607874 27.82 µM 0.474200974305842 0.312940054365978 no 1067 0.317678299331828 343 2252428
SGTC_2425 5628681 7.85 µM 0.47400448619538 0.313013862292764 no 1068 0.317748354054497 355 5714958
SGTC_2913 7966556 36.57 µM 0.473854505159497 0.313070205550844 no 1069 0.317801831807799 353 2976516
SGTC_1634 st006576 41 µM 0.473451604920445 0.313221584379129 no 1070 0.317945510117305 362 3915356
SGTC_1822 st052468 42 µM 0.472632772986113 0.313529335235148 no 1071 0.318237598326594 338 2873678
SGTC_3090 9117696 49.47 µM 0.471670686375468 0.313891093019224 no 1072 0.318580931829815 357 7923821
SGTC_2972 9093619 59.92 µM 0.471105556143585 0.314103673211793 no 1073 0.318782678798011 315 25236256
SGTC_1347 1493-0251 600 nM 0.470140771886589 0.31446673036814 no 1074 0.319127223163289 334 3986378
SGTC_2952 9073731 13.78 µM 0.46833638777583 0.315146218254016 no 1075 0.319772025321489 324 16457353
SGTC_1070 indatraline 8.81 µM 0.468003321075166 0.315271711704423 no 1076 0.319891107368844 374 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2338 7999974 200 µM 0.467195905515595 0.315576019597922 no 1077 0.320179861400976 364 315925
SGTC_2459 5811157 9.22 µM 0.464738914169807 0.316502807127045 no 1078 0.321059218707018 355 2870684 YBR192W RIM2
SGTC_101 0490-5701 117.494 µM 0.46333556837339 0.317032673050622 no 1079 0.321561927288226 364 4661669
SGTC_1052 3253-3998 198 µM 0.462419009263114 0.31737894405376 no 1080 0.321890434998205 329 5450317
SGTC_3158 9100007 49.47 µM 0.461545622390558 0.317709053608447 no 1081 0.322203598749994 339 19297233
SGTC_732 3970-1727 52.7 µM 0.460211570292114 0.318213558200281 no 1082 0.322682183421951 370 1275699
SGTC_1315 1237-0019 3.69 µM 0.460094801230748 0.318257733363743 no 1083 0.322724087750947 343 825140
SGTC_3340 9146634 11.102 µM 0.45807119963656 0.319023696682086 no 1084 0.323450644724362 359 4907387
SGTC_2650 prasterone 100 µM 0.456684545804219 0.319549012613626 no 1085 0.323948900202222 340 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3173 9105693 49.47 µM 0.453979328626099 0.320574891454778 no 1086 0.324921852557618 356 17096658
SGTC_1351 1496-0003 46.5 µM 0.453016691847069 0.320940276279611 no 1087 0.325268361067416 339 3891978
SGTC_45 0kpi-0036 14.9 µM 0.452888247332893 0.320989042660097 no 1088 0.325314607092271 366 2795021
SGTC_2977 9011197 71.43 µM 0.448725318103143 0.322571245124581 no 1089 0.326814909183578 401 2704722
SGTC_1383 3049-0032 20.7 µM 0.448107680870644 0.322806265065484 no 1090 0.327037742505857 389 712864
SGTC_1750 st081859 2.357 µM 0.448032978787643 0.322834695093881 no 1091 0.327064697967442 376 5291695
SGTC_2283 7944793 200 µM 0.447857089159932 0.322901639044566 no 1092 0.327128169453847 362 2970533
SGTC_2105 5350118 200 µM 0.447078396246964 0.323198080068062 no 1093 0.32740922842741 356 2133313
SGTC_1463 k081-0032 34.1 µM 0.445674206609165 0.323732925543234 no 1094 0.327916299484028 347 977755
SGTC_446 go6976 132 µM 0.444737728651391 0.324089825632607 no 1095 0.328254650290252 389 3501 A protein kinase C inhibitor.
SGTC_2486 5283202 22.39 µM 0.443418582304888 0.324592838378551 no 1096 0.328731498777522 352 1377751
SGTC_312 4092-0653 6.84 µM 0.443049265592089 0.324733722466745 no 1097 0.328865050372544 342 1148278
SGTC_2871 9038510 12.99 µM 0.442513353041615 0.32493820284153 no 1098 0.329058884893227 376 4945164
SGTC_2466 5983409 37.09 µM 0.441953422615927 0.325151903719261 no 1099 0.329261455562109 364 2879657
SGTC_1417 3966-0327 90.4 µM 0.441338427328709 0.325386686727626 no 1100 0.329484005273204 364 651118
SGTC_1493 4348-0038 111 µM 0.441225968531344 0.325429626937476 no 1101 0.329524707523721 380 800424
SGTC_569 4130-2812 160 µM 0.439963254651628 0.325911928711251 no 1102 0.329981860540575 368 743552
SGTC_1886 st057356 49.9 µM 0.438740763550766 0.326379144835775 no 1103 0.330424693337162 355 24207747
SGTC_1740 st038286 13.222 µM 0.438730050981041 0.326383240210548 no 1104 0.330428574888413 329 716786
SGTC_674 0498-0004 451 µM 0.438439993430499 0.326494136066178 no 1105 0.330533680157068 348 4231473
SGTC_277 nystatin 15.5 µM 0.437526993715117 0.326843297502264 no 1106 0.330864602004579 384 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3324 9138759 60.749 µM 0.437504818717902 0.326851779846089 no 1107 0.330872641101754 372 45595710
SGTC_352 k048-0007 5.11 µM 0.437249358190125 0.326949504643111 no 1108 0.330965258778169 389 6811911
SGTC_57 miconazole 162.5 nM 0.436618578758127 0.327190856119536 no 1109 0.331193993304021 359 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_156 3474-0145 5.642 µM 0.435572875144923 0.32759112682118 no 1110 0.331573327249691 352 2265471
SGTC_722 3534-0461 190 µM 0.435271443995305 0.327706544389386 no 1111 0.331682704931724 334 658262
SGTC_1872 amphotericin b 148 nM 0.433192749817067 0.328502921230808 no 1112 0.332437372798069 374 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3305 9127027 53.8275 µM 0.432171325523824 0.328894529113707 no 1113 0.332808449155568 360 41905295
SGTC_2452 5863136 48.41 µM 0.431687957240178 0.329079915114457 no 1114 0.33298411063076 351 2184096
SGTC_2246 7293507 91.5585 µM 0.431399226426349 0.32919067196303 no 1115 0.333089056149059 364 887656
SGTC_2123 5259487 200 µM 0.430083308829596 0.329695646388678 no 1116 0.333567520583856 376 2173474
SGTC_1924 st058459 75.1 µM 0.42991304956588 0.329761004936727 no 1117 0.333629446242083 379 688683
SGTC_2225 6654152 15.4 µM 0.429128328095516 0.330062308321425 no 1118 0.333914918905541 376 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1011 4112-3381 17.4 µM 0.428395277408215 0.330343871696524 no 1119 0.33418168119408 374 2877139
SGTC_1354 1498-1681 81 µM 0.427904056326813 0.330532602555556 no 1120 0.334360486883819 360 5754243
SGTC_873 0591-4978 488 µM 0.426570560878336 0.331045158821931 no 1121 0.334846071945998 397 3305145
SGTC_2601 securinine 100 µM 0.425113447090864 0.331605592544712 no 1122 0.335376987824843 363 442872 A GABA receptor antagonist.
SGTC_3057 9095946 49.47 µM 0.424671132092145 0.331775790001218 no 1123 0.335538215424033 365 24540043
SGTC_2288 7946289 167.31 µM 0.423547780213651 0.332208198233965 no 1124 0.335947822869865 393 1246052
SGTC_2754 granisetron 64.02 µM 0.423391460727882 0.332268387517868 no 1125 0.336004837055343 390 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2892 9047358 58.44 µM 0.423206430952068 0.332339637008582 no 1126 0.33607232758113 377 6466771
SGTC_52 0329-0193 875 nM 0.423017984702386 0.332412208310678 no 1127 0.336141069715032 395 3739292
SGTC_1830 st055982 50.3 µM 0.42197983276679 0.332812116795115 no 1128 0.336519868893443 395 455313 An antimicrobial agent.
SGTC_2252 omeprazole 400 µM 0.420860236474743 0.333243611873364 no 1129 0.336928571368645 370 4594 A proton pump inhibitor.
SGTC_127 0180-0333 59.125 µM 0.419245763503459 0.333866222282071 no 1130 0.337518264900718 339 771601
SGTC_2912 7964298 10.93 µM 0.418415075609318 0.334186749787673 no 1131 0.337821833049603 365 2975850
SGTC_374 0880-0231 82.3 µM 0.418175247663108 0.334279311813409 no 1132 0.337909495865653 375 6833587
SGTC_359 0081-0058 15.9 µM 0.417906757807088 0.334382947911066 no 1133 0.338007645722026 427 3494159
SGTC_1979 st071809 45.3 µM 0.417785377094943 0.334429804563898 no 1134 0.338052021589029 397 4976333
SGTC_1214 0358-0031 63.7 µM 0.417350138206173 0.334597841237885 no 1135 0.338211160121153 389 4301366
SGTC_1127 asiatic acid 681.4 nM 0.416014402502422 0.335113747756334 no 1136 0.338699732123864 366 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1123 mangostin 811.285 nM 0.414590791364181 0.335663937374259 no 1137 0.339220745258051 355 5281650 An antioxidant.
SGTC_2531 methyl deoxycholate 70.07 µM 0.413417851829885 0.336117513697729 no 1138 0.339650248774868 374 16667744 Haematoxylin.
SGTC_661 1304-0007 33.6 µM 0.412098746274385 0.336627897680388 no 1139 0.340133523787698 381 3117130
SGTC_886 0866-0150 153 µM 0.410931355369385 0.337079831918267 no 1140 0.340561434964421 384 271463
SGTC_244 nsc-207895 1.295 µM 0.409771585073194 0.337529048946076 no 1141 0.340986756101225 359 42640
SGTC_2545 solidagenone 89.61 µM 0.409414432901757 0.337667432359666 no 1142 0.341117774817765 363 6708572 An anti ulcer agent
SGTC_940 3232-1287 54.8 µM 0.408035286749941 0.338202006988947 no 1143 0.341623884420159 392 1585493 YIL048W NEO1
SGTC_2619 obliquin 87.91 µM 0.406830115542507 0.338669413965113 no 1144 0.342066383165932 383 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3015 9080845 49.47 µM 0.406723149801576 0.338710910990883 no 1145 0.342105667918057 386 5296973
SGTC_80 0159-0065 512.242 µM 0.405898240819566 0.339030997597882 no 1146 0.342408685341804 367 1548079
SGTC_281 1672-3440 14.9 µM 0.4057649121129 0.339082743596936 no 1147 0.342457671089369 373 6833000
SGTC_2413 inermin 26.06 µM 0.404572386305708 0.339545707859721 no 1148 0.342895929828203 413 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_866 0495-0101 262 µM 0.404537024860494 0.339559439637359 no 1149 0.342908928553781 376 635694
SGTC_147 4466-0538 29.23 µM 0.404061622312662 0.339744071602514 no 1150 0.343083702674533 351 6742687 YHR072W ERG7
SGTC_474 dl-dihydrosphingosine 5 µM 0.403647853534692 0.339904798179693 no 1151 0.343235845458275 340 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1033 k072-0102 21.3 µM 0.401836371809124 0.340608802233509 no 1152 0.343902226185603 370 5965931
SGTC_621 3584-0052 32.1 µM 0.400622414861785 0.34108089875242 no 1153 0.344349070127218 397 2273927
SGTC_694 1315-0438 43.2 µM 0.400569345636614 0.341101542561999 no 1154 0.344368609276994 382 6793154
SGTC_1761 st044296 37 µM 0.399465269352018 0.341531133565787 no 1155 0.34477520477295 353 1826700
SGTC_1681 tripelennamine 100 µM 0.397416168556232 0.342328973211079 no 1156 0.345530297195749 335 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1379 2144-0755 36.5 µM 0.39708404652364 0.342458354943475 no 1157 0.345652741970305 388 5392327
SGTC_2487 5918373 44.05 µM 0.396136382014873 0.342827629509743 no 1158 0.346002210023435 400 2876279
SGTC_2395 5646831 180.19 µM 0.396082442481714 0.342848652543107 no 1159 0.346022105129922 394 6808628
SGTC_1479 0549-0158 134 µM 0.394883814022698 0.343315945663482 no 1160 0.346464317921537 340 5440202
SGTC_3308 9128332 17.569 µM 0.394567902291447 0.343439145844643 no 1161 0.346580902855563 381 17332805 YDL196W YDL196W
SGTC_366 0181-0206 4.31 µM 0.393331606140614 0.343921440072052 no 1162 0.347037288617992 372 274874
SGTC_2493 resveratrol 26.09 µM 0.393117898822077 0.344004835683941 no 1163 0.347116202410355 349 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_733 4069-0007 56.1 µM 0.392522081220119 0.344237383335239 no 1164 0.347336249653584 376 5717425 YNL287W SEC21
SGTC_48 0382-0018 55 µM 0.391509244153853 0.344632828858614 no 1165 0.347710428521393 333 762596
SGTC_549 1661-1316 519 µM 0.389588702539962 0.345383138723439 no 1166 0.348420353714078 390 2857282
SGTC_1540 guanosine 70.6 µM 0.385045785502663 0.347160363879868 no 1167 0.350101746916786 403 6802 Guanosine is a purine nucleoside
SGTC_2523 spermine 47.74 µM 0.384941559671866 0.347201177501846 no 1168 0.350140356920148 367 1103 A DNA binding polyamine.
SGTC_916 4466-0038 42 nM 0.384756998724788 0.347273453767395 no 1169 0.350208730516177 384 5722064 YGL116W CDC20
SGTC_1568 digitonin 820 nM 0.384379658251077 0.347421242077286 no 1170 0.350348537523895 406 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2363 9053361 176 µM 0.384187864567704 0.347496368447799 no 1171 0.350419606058625 408 6469797 YMR079W SEC14
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.383498894346948 0.347766290296097 no 1172 0.350674944945007 412 5393153
SGTC_832 4083-0019 164 µM 0.381257663346383 0.348644883613804 no 1173 0.351506032592625 363 1990758
SGTC_2881 9058953 51.95 µM 0.379918372229199 0.34917029224203 no 1174 0.352003004509481 343 17122249
SGTC_1372 2752-0194 270 µM 0.379534939840513 0.349320767420175 no 1175 0.35214533170481 364 823334
SGTC_2898 9056270 58.44 µM 0.379388821602281 0.349378116666367 no 1176 0.352199575138734 383 19154699
SGTC_552 k242-0005 476 µM 0.379019308950958 0.349523160254981 no 1177 0.352336762635432 406 4088318
SGTC_2045 5106652 78.05 µM 0.377894033194078 0.349964996317301 no 1178 0.352754657590584 398 673349
SGTC_2810 7959871 45.46 µM 0.37714196830786 0.35026040561753 no 1179 0.353034051914466 374 2974535
SGTC_2555 cholic acid 100 µM 0.376552983654276 0.350491820672877 no 1180 0.353252916798733 377 6708657 Influences liver metabolism.
SGTC_2237 6667747 47.222 µM 0.37593802334604 0.350733500922438 no 1181 0.353481485960096 420 729940 YDL015C TSC13
SGTC_50 0929-0078 56.389 µM 0.375858935266289 0.350764587033569 no 1182 0.353510885346342 388 1377751
SGTC_1201 1889-3372 45.9 µM 0.373875366161096 0.351544568730773 no 1183 0.354248522258749 375 5392199
SGTC_1812 st052057 4.327 µM 0.373613619287474 0.351647539968798 no 1184 0.354345899926156 357 3645418
SGTC_731 3966-0296 387 µM 0.373136847201621 0.35183513010782 no 1185 0.354523297872876 379 660956
SGTC_1174 0739-0097 51.1 µM 0.372896934387225 0.351929539545656 no 1186 0.354612576868453 392 728447
SGTC_1594 piperine 70.1 µM 0.372004543999167 0.352280789190596 no 1187 0.354944733072791 376 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_218 alverine citrate 93.75 µM 0.370784452437051 0.352761227697392 no 1188 0.35539904120017 406 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2438 5259590 200 µM 0.36954637244765 0.353248989697443 no 1189 0.355860257559201 408 1201127
SGTC_792 4534-1957 155 µM 0.368713713959015 0.353577164913805 no 1190 0.356170562820836 378 1717904
SGTC_250 brefeldin a 552.239 µM 0.367603750881209 0.354014803287347 no 1191 0.356584358791062 407 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1059 3448-6867 171 µM 0.366259977233148 0.354544887077391 no 1192 0.357085545646018 380 3934407
SGTC_2273 7815444 169.05 µM 0.366209995619667 0.354564608967892 no 1193 0.357104192037507 430 2824616
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.364728739298829 0.355149264190579 no 1194 0.357656951716619 393 1241132 A phosphatase inhibitor.
SGTC_1210 3013-0140 750 nM 0.364717923133027 0.355153534612045 no 1195 0.357660989079639 402 905973
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.363632451205411 0.355582191362857 no 1196 0.358066245404773 393 616764
SGTC_2737 bleomycin 30.5 nM 0.363399983005384 0.355674017661904 no 1197 0.358153057233357 399 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2645 abamectin 100 µM 0.363161428550986 0.355768256775159 no 1198 0.358242149508656 384 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_972 1319-0219 195 µM 0.36313784529521 0.355777573638946 no 1199 0.358250957501584 401 23903702
SGTC_2817 7995342 71.43 µM 0.361594278495422 0.356387566360746 no 1200 0.358827620432304 373 18879975
SGTC_729 4092-0585 94.1 µM 0.358842223374279 0.357476045357446 no 1201 0.359856561874114 366 2169061
SGTC_1384 3089-0840 101 µM 0.357511169713342 0.358002913935114 no 1202 0.360354582883327 359 1069836
SGTC_1181 1222-0449 220 µM 0.357474312242354 0.358017507016008 no 1203 0.360368376684148 389 658318
SGTC_116 0155-0182 31.788 µM 0.356051266383424 0.358581095968188 no 1204 0.360901086251432 353 771486
SGTC_271 rotenone 740 µM 0.355581132860425 0.358767357361078 no 1205 0.361077137585022 406 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2673 kobusone 100 µM 0.355329849848151 0.358866926524629 no 1206 0.361171247838493 413 6710676 An epoxy ketone and protein crosslinker.
SGTC_264 promethazine 12.5 mM 0.35406841159014 0.35936690754252 no 1207 0.361643807258539 420 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3137 9097352 49.47 µM 0.353600956077426 0.359552248448236 no 1208 0.361818978873677 421 44120435
SGTC_2472 5377652 49.4 µM 0.352657566054442 0.359926392681032 no 1209 0.362172587629367 400 1610903
SGTC_2837 9008476 45.46 µM 0.35044634304385 0.360803879329861 no 1210 0.363001875992973 398 2992805
SGTC_2586 curcumin 80 µM 0.34964764292211 0.361121010547622 no 1211 0.363301575567053 381 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_439 amiodarone 34.4 µM 0.347933050569222 0.361802127435975 no 1212 0.363945231709013 413 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2876 9059903 25.97 µM 0.346254558012364 0.362469328124983 no 1213 0.364575708088192 388 6916095
SGTC_1859 st055998 20 µM 0.345537094835248 0.362754647312823 no 1214 0.364845313947399 387 676301
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.343358825060973 0.36362136327044 no 1215 0.365664265766446 382 688664
SGTC_87 0100-0052 35.5 µM 0.343209848273214 0.363680665498225 no 1216 0.365720298155809 391 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_261 5-fluorouridine 15.376 µM 0.341767411360376 0.364255015752733 no 1217 0.366262968167714 369 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2534 helenine 20.12 µM 0.341613221662246 0.364316429149177 no 1218 0.366320992879213 400 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_404 fumagillin 50 µM 0.34111014203525 0.364516828807229 no 1219 0.366510333197228 383 12015870 A methionine aminopeptidase binder.
SGTC_2920 7982904 15.77 µM 0.33933956561215 0.365222424702966 no 1220 0.367176969958005 403 6456808
SGTC_2245 6637752 200 µM 0.33788388746124 0.365802871941883 no 1221 0.36772534508555 407 681890
SGTC_1987 st072290 61.9 µM 0.337481361048253 0.365963432427809 no 1222 0.367877030297665 419 54697379
SGTC_2011 4012611 177 µM 0.337124232997388 0.366105903986346 no 1223 0.368011625164092 404 2049887
SGTC_113 0099-0221 2.5 µM 0.33655165632222 0.366334364473412 no 1224 0.368227452390763 430 89219
SGTC_2 0422-0095 29 µM 0.336007579086142 0.366551497470807 no 1225 0.368432575571449 364 6790840
SGTC_859 0439-0102 54.6 µM 0.335702061125527 0.366673443802623 no 1226 0.368547775692726 407 610143
SGTC_289 k017-0060 526 µM 0.334972418743562 0.366964732217283 no 1227 0.368822946064967 423 5512909
SGTC_2515 chrysin 20.77 µM 0.33370206249703 0.367472067571528 no 1228 0.369302196534205 378 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3108 9121785 49.47 µM 0.333594439774283 0.367515058925165 no 1229 0.369342807279418 421 17140271
SGTC_2117 5521686 200 µM 0.33308606945676 0.367718156768942 no 1230 0.369534657266251 387 803312
SGTC_1798 st045719 60.953 µM 0.332115109340193 0.368106165555336 no 1231 0.369901170727071 426 3980186
SGTC_1745 st081495 74 µM 0.331906556285816 0.368189523746994 no 1232 0.369979909786089 386 13842402 YBL026W LSM2
SGTC_171 k064-0041 9.68 µM 0.331433467503888 0.368378639280798 no 1233 0.370158544323912 375 53325
SGTC_2656 pseudo-anisatin 100 µM 0.33084756351881 0.368612896487571 no 1234 0.370379815803424 417 6708809 A neurotoxin.
SGTC_2688 kanamycin b 96.69 µM 0.32970739212299 0.369068901823198 no 1235 0.370810533849098 394 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_208 k072-0098 12.366 µM 0.329527428584815 0.369140894119662 no 1236 0.370878532775147 385 5948901
SGTC_2207 7258803 200 µM 0.3291200558667 0.369303875735981 no 1237 0.371032472777708 415 3666799
SGTC_2847 9005661 71.43 µM 0.327070311431087 0.370124293145234 no 1238 0.371807353014793 407 2991449
SGTC_1962 st076595 64.5 µM 0.324728560289636 0.371062310795764 no 1239 0.372693258545955 397 279619
SGTC_1056 3448-1962 115 µM 0.322804349753149 0.371833651407421 no 1240 0.373421709298139 408 715507
SGTC_1790 st045711 43.5 µM 0.321581461819461 0.372324126995651 no 1241 0.373884894869501 383 585119
SGTC_629 3448-6466 76.7 µM 0.319436496188165 0.373184929252611 no 1242 0.374697769669788 422 573744
SGTC_1751 st044839 27.194 µM 0.318043311196166 0.373744371865885 no 1243 0.375226041825401 374 5291326
SGTC_1684 st024538 14.6195 µM 0.317456210773471 0.373980205679923 no 1244 0.375448730536436 391 6732859
SGTC_2697 mebhydrolin 72.4 µM 0.317079244556087 0.374131655045202 no 1245 0.375591736685578 398 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_19 0279-0214 38.434 µM 0.316799963027712 0.374243871291344 no 1246 0.375697696132318 401 3566274 YBR002C RER2
SGTC_1223 0764-0573 147 µM 0.312262547540621 0.376068506479395 no 1247 0.377420500333082 397 1609797
SGTC_1971 st069429 63.5 µM 0.310388757626323 0.376822827069945 no 1248 0.378132671193214 420 1246522 YGL099W LSG1
SGTC_1791 st048313 56.1 µM 0.309451329253843 0.377200378839809 no 1249 0.378489114988082 413 1204976
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.308807826500849 0.377459619274409 no 1250 0.378733857627827 380 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3327 9140648 26.9345 µM 0.306077549380742 0.378560147013005 no 1251 0.379772800571144 438 8029710
SGTC_2495 cafestol 54.53 µM 0.305196827089929 0.378915361702072 no 1252 0.380108124409955 414 16667697 An anti-infammatory.
SGTC_2667 digitoxin 100 µM 0.305140734651353 0.378937988485427 no 1253 0.380129483950268 406 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_604 1000-0114 314 µM 0.304990049588247 0.378998774459067 no 1254 0.380186865395839 417 1572745
SGTC_2747 doxorubicin 7.63 µM 0.304624413793803 0.37914628345223 no 1255 0.380326111858865 423 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3096 9117468 49.47 µM 0.303428802811251 0.379628753332992 no 1256 0.380781549105736 418 41316311
SGTC_3123 9126162 49.47 µM 0.301851264453274 0.380265630726629 no 1257 0.381382724534916 370 25239884
SGTC_1905 st060207 84.5 µM 0.300986915919396 0.380614719841878 no 1258 0.381712235881029 411 1948547
SGTC_3346 9158254 43.5805 µM 0.300353273307818 0.380870694291974 no 1259 0.381953850818164 411 17639500
SGTC_983 1491-0821 12.2 µM 0.300327388143061 0.380881152306753 no 1260 0.38196372209613 379 46495113
SGTC_2206 7254556 146.969 µM 0.299960890955422 0.381029232285542 no 1261 0.382103493611621 398 4398905
SGTC_1970 st070122 35.8 µM 0.298880947910301 0.381465675058066 no 1262 0.382515442202354 429 102928
SGTC_3044 9093193 49.47 µM 0.295724889263477 0.382742011050186 no 1263 0.383720094000758 431 25236277
SGTC_3262 9137218 49.47 µM 0.29495816634665 0.383052273031936 no 1264 0.384012918548282 399 17650664
SGTC_2449 5812982 45.77 µM 0.293482475528482 0.383649636910434 no 1265 0.384576696288229 417 776185
SGTC_2757 clomiphene 4.22 µM 0.292878901342681 0.383894045267848 no 1266 0.384807358177112 448 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_718 1130-0073 349 µM 0.292312737899763 0.384123346689969 no 1267 0.385023760244977 422 6740020
SGTC_1026 k007-1105 30.6 µM 0.292300473584653 0.384128314300004 no 1268 0.385028448374713 382 7066794
SGTC_2942 9052777 62.25 µM 0.292239467623276 0.384153024794788 no 1269 0.385051768627135 433 6469503
SGTC_2159 5658611 73.75 µM 0.290771898430858 0.384747606119957 no 1270 0.385612889478422 430 793844
SGTC_1344 1488-0097 29.1 µM 0.289966497884167 0.385074027111379 no 1271 0.385920933910828 424 747966
SGTC_899 1083-0020 478 µM 0.288619917857312 0.385619964716191 no 1272 0.386436125815264 444 767123
SGTC_1638 st008370 60.6 µM 0.284847822877946 0.387150471111122 no 1273 0.387880365929913 386 24207134
SGTC_697 0508-1955 564 µM 0.284846744498589 0.387150908909708 no 1274 0.387880779037094 416 6243113
SGTC_3059 1327-0034 3 µM 0.284323536240498 0.387363337013659 no 1275 0.388081225398959 392 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1799 st045822 46.1415 µM 0.282530353829311 0.388091643642446 no 1276 0.388768437603697 446 3674992
SGTC_1957 st077035 62.4 µM 0.281502204452983 0.388509407499643 no 1277 0.389162618755023 443 705593
SGTC_2185 6113692 200 µM 0.278741594952894 0.38963175194705 no 1278 0.390221569467049 416 874150
SGTC_2348 9022543 33.42 µM 0.276554114032253 0.390521741701811 no 1279 0.391061251269475 455 3162678 YDL140C RPO21
SGTC_3302 9125395 16.351 µM 0.276080316949619 0.390714584668039 no 1280 0.391243189091357 422 17599668
SGTC_2153 5569715 200 µM 0.275545537867579 0.390932280573182 no 1281 0.391448572558078 443 2054701
SGTC_3270 9137563 49.47 µM 0.275314574929979 0.391026310691207 no 1282 0.391537283909903 451 17015724
SGTC_765 1319-0117 244 µM 0.274304203985524 0.391437729865602 no 1283 0.391925427031363 405 3487746 YGL099W LSG1
SGTC_1160 4092-0570 10.5 µM 0.273846319568483 0.391624218672654 no 1284 0.39210136291337 417 4994975
SGTC_3195 9113082 49.47 µM 0.271543996987632 0.392562293546733 no 1285 0.392986332826387 451 17018038
SGTC_2867 9039098 71.43 µM 0.271118148291326 0.392735873005152 no 1286 0.393150081912661 420 6463460
SGTC_2719 novobiocin 32.65 µM 0.271084895031504 0.392749428207985 no 1287 0.39316286938862 427 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2986 9022445 71.43 µM 0.270677803672776 0.392915383558833 no 1288 0.393319424913177 457 6459286
SGTC_1114 scopoletin 1.73284 µM 0.270085413579406 0.393156912780491 no 1289 0.393547271766083 451 5280460 A coumarin with genotoxic properties.
SGTC_2476 5806916 10.51 µM 0.269608712515566 0.393351303156458 no 1290 0.393730648434201 444 2870194
SGTC_3356 9151811 4.48 µM 0.269252061331084 0.39349675667763 no 1291 0.393867859905937 442 1859254 YPR165W RHO1
SGTC_2745 rifampicin 24.3 µM 0.268764384918644 0.393695670444758 no 1292 0.394055500958364 445 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_505 gw-5074 63.9 µM 0.268389027856323 0.393848790220521 no 1293 0.3941999421544 438 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.26825461875256 0.393903623850503 no 1294 0.39425166767704 441 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_12 0849-0099 9.267 µM 0.268101541830199 0.393966075778489 no 1295 0.39431057952829 442 6071388
SGTC_2175 5807670 165.306 µM 0.267236561304686 0.394319019495641 no 1296 0.394643513793956 414 241186
SGTC_2138 5575593 77.673 µM 0.266131487070685 0.39477005646858 no 1297 0.395068972981496 442 762213
SGTC_841 0251-0215 91.2 µM 0.26595222913837 0.394843234057885 no 1298 0.395138000004228 443 3888614
SGTC_702 1488-0190 94 µM 0.26592335746101 0.394855020548528 no 1299 0.395149117956284 428 949357
SGTC_1946 st076057 65.1 µM 0.265612251100064 0.394982031818794 no 1300 0.395268924708977 428 953009
SGTC_2210 7115885 190.385 µM 0.265217320874725 0.395143280821605 no 1301 0.395421026208958 446 2927039
SGTC_3011 9081274 71.4286 µM 0.264578464069293 0.395404162434896 no 1302 0.395667106124198 414 6625322
SGTC_2040 5100729 123 µM 0.26256199773642 0.396227907465083 no 1303 0.396444096989697 424 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2232 chlorophetanol 41.5365 µM 0.262543636020457 0.39623541052995 no 1304 0.396451174076248 432 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_750 4073-0104 132 µM 0.261151896635894 0.396804222363053 no 1305 0.396987686041844 439 22330957
SGTC_1366 1683-0113 21.9 µM 0.26082857474748 0.396936397349324 no 1306 0.397112353754215 403 708623
SGTC_553 k007-0256 45.7 µM 0.260327316794236 0.397141336550816 no 1307 0.397305651528036 415 6287000
SGTC_2335 9018011 154.17 µM 0.259373534276583 0.397531368719087 no 1308 0.397673523871846 443 6458208
SGTC_973 1325-0077 65.9 µM 0.258597764419576 0.397848681403131 no 1309 0.397972804162223 452 2835149
SGTC_1498 4478-3555 97.6 µM 0.258093129068269 0.398055128397275 no 1310 0.398167517100744 446 3437919
SGTC_815 1582-0027 36.9 µM 0.257561337544762 0.398272715907088 no 1311 0.398372735660038 429 3128206
SGTC_473 2-arachidonoylglycerol 10 µM 0.257555890069344 0.398274944956755 no 1312 0.398374837988501 436 5282280 An endocannabinoid.
SGTC_2862 9027634 71.43 µM 0.257169830653944 0.398432924860125 no 1313 0.398523836292538 415 5012562
SGTC_2455 5377712 9.75 µM 0.256481348754053 0.39871470078388 no 1314 0.398789590217161 387 2243908
SGTC_198 3454-2873 16.191 µM 0.256384405742267 0.398754381026489 no 1315 0.398827013979325 437 710957
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.256187623021569 0.398834930391548 no 1316 0.398902982601137 440 229346 A bile salt which induces apoptosis.
SGTC_2201 6605497 169.863 µM 0.255443951060439 0.399139377630813 no 1317 0.399190114191002 446 670741
SGTC_1862 st057513 3.81 µM 0.255241268135402 0.399222363381455 no 1318 0.399268379492247 424 5393163
SGTC_2836 9010338 19.48 µM 0.254914617337635 0.399356115664783 no 1319 0.399394523072973 416 2994051
SGTC_180 1486-1293 102.781 µM 0.253925936576846 0.399761018416032 no 1320 0.399776388430647 422 4140536
SGTC_966 1300-0360 30.2 µM 0.253633498605238 0.399880803679836 no 1321 0.399889357264295 443 70588
SGTC_351 caspofungin 25 nM 0.252657889997828 0.400280489963391 no 1322 0.400266295577041 416 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1643 st009866 20.2 µM 0.252584754554532 0.400310456227074 no 1323 0.400294556097955 430 3156273 YOR207C RET1
SGTC_194 1486-1323 56.904 µM 0.251591637427937 0.40071743062799 no 1324 0.400678361557476 436 5178754
SGTC_1558 st069300 45.6 µM 0.250564893516497 0.4011382984418 no 1325 0.401075263439199 433 24208000
SGTC_980 1473-0395 201 µM 0.249141871305888 0.401721792477166 no 1326 0.401625520877087 462 768876
SGTC_728 3030-5151 22.5 µM 0.248528307726292 0.401973444925189 no 1327 0.401862835288933 422 3125388
SGTC_258 haloperidol 50.781 µM 0.247734496413951 0.402299086085276 no 1328 0.40216991969156 448 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3179 9107801 49.47 µM 0.24604392001447 0.40299282835131 no 1329 0.402824117018405 390 4818259
SGTC_3285 9112818 20.8695 µM 0.244357537965257 0.403685153801724 no 1330 0.40347696243324 449 17017947 YPR165W RHO1
SGTC_1456 k015-0012 13 µM 0.24335177950051 0.404098200643658 no 1331 0.403866447726659 437 2989616
SGTC_211 3455-0679 143.504 µM 0.243342870313366 0.404101859964478 no 1332 0.403869898283131 418 748649
SGTC_2931 9014674 55.67 µM 0.243035318617996 0.404228187554293 no 1333 0.403989018616074 419 2996810
SGTC_3292 9120825 59.784 µM 0.242804523143446 0.40432299390416 no 1334 0.4040784157254 460 24824900
SGTC_1339 1486-1321 22.7 µM 0.242447666911676 0.404469594651563 no 1335 0.404216651500062 432 3469382
SGTC_263 alizarin 107.927 µM 0.241889488572071 0.404698927786166 no 1336 0.404432897610859 454 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2887 9044784 58.44 µM 0.241611082059541 0.404813326119774 no 1337 0.404540767113151 469 6465546
SGTC_1883 5-benzylidenerhodanine 20 µM 0.241228111786918 0.4049707034062 no 1338 0.404689162036239 443 1273210
SGTC_706 4262-0057 46.9 µM 0.24115576013783 0.40500043722211 no 1339 0.404717198696186 433 883298
SGTC_209 4077-0173 175.592 µM 0.238739328746024 0.405993813968471 no 1340 0.405653859228765 443 15993494
SGTC_3234 9132280 49.47 µM 0.238291225338295 0.406178092653667 no 1341 0.405827613265436 418 17612295
SGTC_202 3594-0513 34.79 µM 0.238170884559731 0.406227585309669 no 1342 0.405874279085297 424 708429
SGTC_3070 9117005 49.47 µM 0.237800873682941 0.406379769385848 no 1343 0.406017770502649 448 8779016
SGTC_3171 9103192 49.47 µM 0.236881972140745 0.406757771249775 no 1344 0.40637417807384 460 13018434
SGTC_1484 3473-2379 286 µM 0.235048878629498 0.407512096860555 no 1345 0.407085398038459 469 671917
SGTC_2762 leflunomide 42.06 µM 0.234939397542188 0.407557159667965 no 1346 0.40712788520895 427 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1705 st027868 56.3335 µM 0.234511004587399 0.407733499494153 no 1347 0.407294145469063 472 292948
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.23424099241826 0.407844654484296 no 1348 0.407398946377323 439 77254
SGTC_2337 9009472 200 µM 0.233291763403782 0.408235479182735 no 1349 0.407767427013652 457 5742383
SGTC_27 0485-0001 32.618 µM 0.233243577475735 0.408255321143975 no 1350 0.407786134459024 466 2054479
SGTC_1478 0453-0656 35.7 µM 0.231662799824488 0.408906382600961 no 1351 0.408399963414453 447 5258496
SGTC_1596 piperlongumine 63 µM 0.228776724523478 0.410095693263424 no 1352 0.409521229096509 413 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_496 calpeptin 138 µM 0.228066590657485 0.410388456620221 no 1353 0.409797236231271 415 73364 A calpain inhibitor.
SGTC_2683 piperine 63.03 µM 0.227251716648426 0.410724462204274 no 1354 0.410114007703663 471 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_58 0957-0393 9 µM 0.226651288037604 0.410972085201556 no 1355 0.410347453919582 428 6997992
SGTC_2364 9055074 200 µM 0.226152124158211 0.411177972585506 no 1356 0.410541552669186 436 6470630
SGTC_3300 9124615 50.48 µM 0.222957620148329 0.412496169121723 no 1357 0.411784245240602 428 24824903
SGTC_2879 9041815 71.43 µM 0.222856945310951 0.412537728233716 no 1358 0.4118234231687 435 4942971
SGTC_606 k015-0008 38.6 µM 0.221704876308449 0.413013378190027 no 1359 0.412271816917527 445 1970475
SGTC_1330 1469-0054 61.8 µM 0.220732028785939 0.413415133215493 no 1360 0.412650545568702 466 7102664
SGTC_3081 9117243 49.47 µM 0.220212223875054 0.413629833273068 no 1361 0.412852938506933 442 45595589
SGTC_924 2046-0044 21.3 µM 0.219162969118806 0.414063295741342 no 1362 0.413261550297636 418 3623589
SGTC_2779 methotrexate 400 µM 0.218430573642583 0.414365921097873 no 1363 0.413546823141177 464 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1039 k821-0043 94 µM 0.217188262989875 0.41487935926475 no 1364 0.41403081558195 450 15992768
SGTC_967 1306-0166 352 µM 0.216068193199204 0.415342400854669 no 1365 0.414467296124322 479 4437607
SGTC_1304 1165-0502 251 µM 0.215168441567273 0.415714447195576 no 1366 0.414817997319793 424 767425
SGTC_1133 3473-0247 50 µM 0.215102977381344 0.415741519519611 no 1367 0.414843516312661 420 711311
SGTC_523 1934-0222 13.7 µM 0.214641686156693 0.415932295086953 no 1368 0.41502334523476 474 1361595
SGTC_1831 st055328 12 µM 0.212871627245424 0.416664519367444 no 1369 0.41571354667426 457 1103068
SGTC_2634 4'-methoxyflavone 100 µM 0.212515841718748 0.416811732965367 no 1370 0.4158523100633 431 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3153 9100258 49.47 µM 0.212354475597512 0.416878505372163 no 1371 0.415915249500242 470 25236848
SGTC_1553 gossypol 38.6 µM 0.212081174283269 0.416991601410636 no 1372 0.416021853194124 480 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_854 0422-0053 192 µM 0.211243658641579 0.417338220244393 no 1373 0.416348572329885 446 3596728
SGTC_2725 haloperidol 53.21 µM 0.209522437004584 0.418050775922992 no 1374 0.417020210935887 470 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2165 5727197 32.143 µM 0.20947114179687 0.418072015383124 no 1375 0.417040230586968 452 1361712
SGTC_77 0828-0286 12.516 µM 0.209018003934558 0.418259653488181 no 1376 0.417217091960261 417 745345
SGTC_2917 7979103 53.79 µM 0.20822214618385 0.418589252153701 no 1377 0.417527758692916 465 2980565
SGTC_2966 9084041 48.03 µM 0.207841142757328 0.41874706218338 no 1378 0.417676503368151 412 17741380
SGTC_3037 9091026 49.47 µM 0.207597921954073 0.418847810065208 no 1379 0.417771463529412 444 25236398 YIL048W NEO1
SGTC_2716 st080858 38.6235 µM 0.207430165752535 0.418917301803577 no 1380 0.417836963007244 455 5296050
SGTC_893 0958-0369 48.9 µM 0.205458909809106 0.419734068641316 no 1381 0.418606799227706 464 6819948
SGTC_2654 protoveratrine a 100 µM 0.205376419979333 0.419768254901454 no 1382 0.41863902086744 478 5702278 A heart drug and vasodilator.
SGTC_1698 5-fluorocytosine 1.055 µM 0.205238406524549 0.419825453171329 no 1383 0.41869293200433 460 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3094 9117742 49.47 µM 0.205046435769623 0.419905016310539 no 1384 0.418767922606492 478 17149698
SGTC_689 0833-0039 98 µM 0.204285838812443 0.420220281276403 no 1385 0.419065067811405 479 5374726
SGTC_391 gliotoxin 8.33 µM 0.204163662297584 0.420270927821932 no 1386 0.419112803267398 444 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1230 0170-0365 3.77 µM 0.202731336829831 0.420864776318069 no 1387 0.419672514248854 456 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_605 1315-0399 119 µM 0.202487501785872 0.420965889387643 no 1388 0.419767814088053 443 24020461
SGTC_2214 7179297 48.276 µM 0.201822754145475 0.421241572184233 no 1389 0.420027646169495 461 769744
SGTC_1364 1653-0028 37.6 µM 0.20004373335291 0.421979553694414 no 1390 0.420723189027555 482 5718652
SGTC_1734 st037168 69.4 µM 0.199419685956416 0.422238488937497 no 1391 0.420967231284549 417 708907
SGTC_2710 st078562 53.7235 µM 0.199395804399861 0.422248398751808 no 1392 0.420976571097366 469 17250908
SGTC_2626 ethyl orsellinate 100 µM 0.19689923103803 0.423284639216504 no 1393 0.42195319772146 451 75653 A natural product.
SGTC_2517 totarol 10 µM 0.196300041646115 0.423533421087862 no 1394 0.422187664397702 432 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2227 7312221 64.1025 µM 0.195770257792533 0.42375341135787 no 1395 0.422394995214324 475 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2130 NSC 7 2.4545 µM 0.19388137714578 0.424537953178472 no 1396 0.423134382947711 474 21448
SGTC_1103 duloxetine 36.1 µM 0.192731521296026 0.42501568955179 no 1397 0.423584617911194 446 60835 A selective serotonin reuptake inhibitor.
SGTC_2960 9079389 5.97 µM 0.192713118431591 0.425023336379472 no 1398 0.423591824508139 449 16457355
SGTC_139 0099-0334 718.624 µM 0.192386150097575 0.425159204196295 no 1399 0.423719870192589 447 97690
SGTC_917 harmaline 728.087 nM 0.192343755910928 0.425176821249577 no 1400 0.423736472979619 435 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_40 0327-0103 19.753 µM 0.191422033817512 0.425559882984732 no 1401 0.42409747937396 441 409036
SGTC_3075 9116269 49.47 µM 0.190944876361309 0.425758214163288 no 1402 0.424284390348998 466 17015205 YNL244C SUI1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.19026909208063 0.426039136994107 no 1403 0.424549136077676 478 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2962 9082311 13.18 µM 0.190207063806798 0.426064923966786 no 1404 0.424573438025734 446 16459453
SGTC_3185 9108267 49.47 µM 0.189212503232699 0.426478435067131 no 1405 0.424963134253175 453 4910486
SGTC_1620 st003704 16.5 µM 0.18808938032079 0.426945496033294 no 1406 0.425403292901168 467 2834414
SGTC_1147 3809-1045 12.3 µM 0.188047413446347 0.426962950332479 no 1407 0.425419741778197 445 325925
SGTC_39 0986-0283 58.349 µM 0.187410800471425 0.427227739375468 no 1408 0.425669277539784 441 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_35 0133-0054 64.071 µM 0.186845738130413 0.427462795542556 no 1409 0.425890792255187 443 99677
SGTC_358 0075-0058 9.45 µM 0.186799304973898 0.427482112079201 no 1410 0.425908995937956 479 1069125
SGTC_2044 5102272 200 µM 0.185691770399226 0.427942906079402 no 1411 0.42634324117525 446 592666
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.185481067704646 0.428030580889221 no 1412 0.426425864201924 449 6708739 YPR165W RHO1
SGTC_353 1988-1175 58.3 µM 0.183472952935211 0.428866348662715 no 1413 0.42721346948621 457 2788357
SGTC_2332 7982454 138.89 µM 0.182526752862126 0.429260263428926 no 1414 0.427584680621332 487 2981748
SGTC_1143 3454-2408 5.08 µM 0.180626158151662 0.43005171696684 no 1415 0.428330511177825 460 X1143
SGTC_490 phenamil 164 µM 0.180506645648979 0.43010149428748 no 1416 0.428377418807616 471 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2095 5432005 200 µM 0.180444802964612 0.430127252389718 no 1417 0.428401691926875 494 783734
SGTC_610 4215-0184 155 µM 0.180406835847323 0.430143066224611 no 1418 0.428416594072126 467 5605015
SGTC_3134 9127454 49.47 µM 0.179568310849917 0.430492352124919 no 1419 0.428745742259872 479 24262820
SGTC_3221 9128209 49.47 µM 0.177825965530874 0.431218296176097 no 1420 0.429429827397355 467 16460723
SGTC_1126 isoteolin 1.0172 µM 0.177672549353816 0.431282227831762 no 1421 0.429490072326584 431 133323
SGTC_2262 9014885 67.46 µM 0.177424757621743 0.431385491511147 no 1422 0.429587381017445 482 6457424
SGTC_514 4466-0038 2.65 nM 0.176468126631099 0.431784197808479 no 1423 0.429963093484493 465 5722064
SGTC_59 0330-0160 1.33 µM 0.176373578252193 0.43182360762375 no 1424 0.430000230379775 464 4293482
SGTC_1089 terbinafine 2.25 µM 0.176106553653927 0.431934912931497 no 1425 0.430105116161605 449 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1242 0402-0103 60.1 µM 0.174922162221343 0.432428674235237 no 1426 0.430570397907791 440 432868
SGTC_1389 3405-0187 19 µM 0.174385778566607 0.432652322149302 no 1427 0.430781145069512 488 799890
SGTC_203 k066-0004 30.888 µM 0.174083459711021 0.432778385058252 no 1428 0.430899935979108 478 6795412
SGTC_2799 7812892 81.82 µM 0.173412610220781 0.43305814471818 no 1429 0.431163556873219 471 20205235
SGTC_856 0433-0016 11.3 µM 0.169713103489058 0.434601523061882 no 1430 0.432617884237877 467 3911780
SGTC_2083 5306046 65.942 µM 0.169604925530043 0.434646668392694 no 1431 0.432660424331705 433 539837
SGTC_575 k072-0246 11.9 µM 0.168831616022951 0.434969414310119 no 1432 0.432964544646887 474 6796779
SGTC_709 3807-1509 243 µM 0.16869679414434 0.435025687568935 no 1433 0.43301757027135 482 1886677 YPL242C IQG1
SGTC_1413 3910-0535 34.4 µM 0.168403565636007 0.435148082660358 no 1434 0.433132901597017 478 2876951
SGTC_2520 obtusaquinone 4.71 µM 0.166130512578862 0.436097076633113 no 1435 0.434027121116251 493 5967872
SGTC_2852 9023854 51.95 µM 0.166054429228247 0.436128847637383 no 1436 0.434057058187995 497 19798528
SGTC_1313 1220-0047 237 µM 0.163534423319262 0.437181387305445 no 1437 0.435048836030634 466 3528706
SGTC_453 enantio-paf c16 10 µM 0.163471691119308 0.437207594587025 no 1438 0.435073530263113 487 13871343 A lipid and platelet activating factor
SGTC_1013 4112-3890 241 µM 0.16310364538799 0.43736135654766 no 1439 0.435218414814844 460 705171
SGTC_96 0929-0093 37.281 µM 0.162688743959257 0.437534705201326 no 1440 0.435381754966368 441 6991579
SGTC_452 diindolylmethane 8 µM 0.162367048683642 0.437669119941382 no 1441 0.435508408914877 499 3071 Inhibits expression of several cancer promoting factors.
SGTC_290 2043-6722 48.1 µM 0.161903094898291 0.437862987573691 no 1442 0.435691082799898 474 773758 YLR208W SEC13
SGTC_2372 9071633 200 µM 0.161076556539758 0.438208401647396 no 1443 0.436016552146569 484 21321366
SGTC_2524 avocatin b 10.57 µM 0.160287908865068 0.438538024931899 no 1444 0.436327141528996 486 6710748
SGTC_397 arbidol 50 µM 0.159949027469907 0.438679676954263 no 1445 0.436460613657339 470 131410 A RNA synthesis inhibitor.
SGTC_1948 st076329 66.6 µM 0.159818333253668 0.438734309081904 no 1446 0.436512090931814 493 24208413
SGTC_3264 9137442 49.47 µM 0.159815376283188 0.438735545153084 no 1447 0.436513255623041 433 17015726
SGTC_1427 4048-4900 550 nM 0.159546966070906 0.438847748330271 no 1448 0.436618979301002 478 24132586
SGTC_112 phenothiazine 287.218 µM 0.15747481824092 0.439714130383761 no 1449 0.437435326201896 496 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1211 1056-0033 32.3 µM 0.155762626704739 0.440430229844807 no 1450 0.438110065279592 482 6741922
SGTC_257 daunorubicin 18.5 µM 0.155724608960864 0.440446132439046 no 1451 0.438125049331424 479 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_329 k048-0121 21.3 µM 0.15555831594769 0.440515692937715 no 1452 0.438190591957135 456 6832902
SGTC_1072 oxiconazole 14.9 nM 0.154894763553276 0.440793275683699 no 1453 0.438452140952032 478 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1078 idebenone 36.1 µM 0.154483943997221 0.440965147721664 no 1454 0.438614085040633 495 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1343 1487-0095 224 µM 0.154359709015048 0.441017125334476 no 1455 0.438663060199408 497 4560101 YGL055W OLE1
SGTC_2990 9074105 71.4286 µM 0.153270391950779 0.441472918809356 no 1456 0.439092524283774 495 6502001
SGTC_1943 st076331 65.2 µM 0.153001074019209 0.441585619146839 no 1457 0.439198714159375 495 24208415
SGTC_188 3229-0966 278.469 µM 0.152350762705093 0.441857771656761 no 1458 0.439455144659851 486 5722370
SGTC_1105 epirubicin 18.1 µM 0.148709476495811 0.443382137954035 no 1459 0.440891441614008 478 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_176 1486-1328 72.834 µM 0.147019680447102 0.444089830218627 no 1460 0.441558243182429 447 22310231
SGTC_2250 alverine citrate 130 µM 0.146810224270299 0.444177563636108 no 1461 0.441640907166064 498 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_145 3737-0113 38.366 µM 0.146761572819125 0.444197942314711 no 1462 0.441660108313772 467 6849351
SGTC_1370 2001-0092 44.6 µM 0.146259914506593 0.444408080992626 no 1463 0.441858104544374 495 790957
SGTC_2343 7990716 14.84 µM 0.146031609688517 0.444503720333168 no 1464 0.441948217489576 481 6456862
SGTC_292 k038-0015 474 µM 0.144602163636428 0.445102603869801 no 1465 0.442512494428093 463 46368540
SGTC_1209 2323-2347 50.3 µM 0.143846219360801 0.445419366521112 no 1466 0.442810952302541 475 5412760
SGTC_734 2023-0417 80 µM 0.142692172248456 0.445903012988759 no 1467 0.443266649547583 496 3935732
SGTC_513 4245-1575 41.7 µM 0.140895190748298 0.446656265097521 no 1468 0.443976370737588 465 719745
SGTC_1216 1165-0504 9.65 µM 0.14088056582047 0.446662396314496 no 1469 0.44398214762038 465 6304004
SGTC_382 3229-0966 23.2 µM 0.140447453355076 0.446843976078185 no 1470 0.444153233509667 491 5722370
SGTC_2066 5222451 176 µM 0.139221987225251 0.447357805543064 no 1471 0.444637367203592 498 2281147
SGTC_67 0335-0847 266 µM 0.137947687112982 0.44789220446717 no 1472 0.445140880891451 481 4552207 YOR254C SEC63
SGTC_1774 st048371 48.465 µM 0.13632329236287 0.448573558411249 no 1473 0.445782855563683 495 4242727
SGTC_3056 9094900 49.47 µM 0.136056892153394 0.448685314770255 no 1474 0.445888152815297 453 25236784
SGTC_3182 9108849 49.47 µM 0.134150597213168 0.449485134318909 no 1475 0.446641745203407 464 17133045
SGTC_2296 7971656 126.45 µM 0.133995234838132 0.449550328424679 no 1476 0.446703171251678 471 666570
SGTC_3128 9127691 49.47 µM 0.133552847122097 0.449735973305437 no 1477 0.446878086295985 493 41316314
SGTC_976 1348-1067 47.6 µM 0.132636192598363 0.450120675871627 no 1478 0.447240553867305 466 5310671 YGL099W LSG1
SGTC_1430 4049-0248 69.1 µM 0.131940346552953 0.450412740613491 no 1479 0.447515737819354 488 22774488
SGTC_1139 k015-0024 46.9 µM 0.131895753269554 0.450431458495449 no 1480 0.447533373841654 491 2766652
SGTC_2315 7733312 200 µM 0.131496433265158 0.450599076644525 no 1481 0.447691303959213 454 726316
SGTC_2310 7668677 200 µM 0.131495533097444 0.450599454507952 no 1482 0.447691659982793 494 2197143
SGTC_506 n9-isopropylolomoucine 153 µM 0.130829028037766 0.45087924562307 no 1483 0.44795527964942 496 6610355
SGTC_2617 dihydrotanshinone i 20.83 µM 0.13076327828716 0.450906847932899 no 1484 0.44798128659208 486 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3027 9089541 49.47 µM 0.129329618195863 0.45150876954754 no 1485 0.448548418149769 482 9943819
SGTC_2996 9066192 71.4286 µM 0.129070894594218 0.451617406465049 no 1486 0.448650776042852 480 6472854
SGTC_153 4077-0274 519.67 µM 0.127214849273982 0.452396857588576 no 1487 0.449385176424574 501 3121976
SGTC_1307 1187-1599 12.2 µM 0.127090660002328 0.452449017783362 no 1488 0.449434321878125 495 1538471
SGTC_1527 coumarin 137 µM 0.126800950377968 0.452570700648813 no 1489 0.449548971759046 504 323 A hepatotoxic, DNA x-linker.
SGTC_2403 6032726 181.2 µM 0.126491435358867 0.452700707031341 no 1490 0.449671464093447 490 2881040
SGTC_3087 9117406 49.47 µM 0.125904058352088 0.452947438423794 no 1491 0.449903935071331 449 42546093
SGTC_3187 9109394 49.47 µM 0.125288889645342 0.453205863369343 no 1492 0.450147423827178 485 17098090
SGTC_1274 0865-0114 173 µM 0.125096838467453 0.453286545814678 no 1493 0.450223443086985 467 870624
SGTC_344 k064-0035 6.43 µM 0.124968914805733 0.453340288777827 no 1494 0.450274079885188 492 5088750
SGTC_1671 st016596 74.5 µM 0.124944868295361 0.453350391232004 no 1495 0.450283598451515 501 2829167
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.124695723366587 0.453455064129871 no 1496 0.450382221617341 500 91467 include heat shock
SGTC_1008 4106-0037 6 µM 0.124655154958309 0.453472108382775 no 1497 0.450398280772898 514 2905394
SGTC_1933 st074711 15.9 µM 0.124252502092119 0.453641282030065 no 1498 0.450557676809084 509 17250958
SGTC_2385 9074692 200 µM 0.122515114604446 0.454371337340272 no 1499 0.451245538220608 456 17046906
SGTC_3144 9087057 49.47 µM 0.122420003427654 0.454411307808724 no 1500 0.451283198607795 511 17249618
SGTC_772 k072-0172 35.3 µM 0.120909556615226 0.455046134638494 no 1501 0.451881336312042 446 5861980
SGTC_3014 9081533 49.47 µM 0.120355214415035 0.455279148428073 no 1502 0.452100883580173 501 21367265
SGTC_1422 4031-0024 15.5 µM 0.12034869228429 0.455281890050942 no 1503 0.452103466757838 505 782427
SGTC_2968 9090663 33.37 µM 0.120059679428168 0.455403380744748 no 1504 0.452217936223523 500 25236811
SGTC_3279 9140807 49.47 µM 0.119891707882943 0.455473991906889 no 1505 0.452284466622687 496 45595718
SGTC_95 0471-0001 561.058 µM 0.119256517927579 0.455741023050766 no 1506 0.452536065625755 500 4015405
SGTC_464 bw-b 70c 158 µM 0.119087284467509 0.455812171452648 no 1507 0.452603102288628 499 5353454
SGTC_1342 1486-1464 234 µM 0.118719245678181 0.455966905622989 no 1508 0.452748894267928 497 3253938
SGTC_2505 galangin 7.89 µM 0.118502407726986 0.45605807370829 no 1509 0.45283479372484 502 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2985 9022375 71.43 µM 0.118163726843672 0.456200474477193 no 1510 0.452968965169718 469 4939335
SGTC_2065 5221596 34.26 µM 0.117574018592845 0.456448434890751 no 1511 0.453202596144901 469 788581
SGTC_1104 tacrolimus 29.8 µM 0.117507638156171 0.456476347587997 no 1512 0.453228895802712 476 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2657 nystatin 74.44 µM 0.117171347792356 0.456617759583075 no 1513 0.453362135820741 481 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1499 4480-0877 67.3 µM 0.117089412722228 0.456652214575371 no 1514 0.453394599724204 490 2861909
SGTC_111 0083-0039 52.457 µM 0.116907407159173 0.456728751957603 no 1515 0.45346671417161 504 759313
SGTC_3336 9143619 71.43 µM 0.116899806179189 0.45673194837347 no 1516 0.453469725873781 509 45595730
SGTC_1308 1187-1617 41.4 µM 0.11483582393092 0.457600011153135 no 1517 0.45428762674286 509 2882570
SGTC_1955 wogonin 32.4 µM 0.113689151109285 0.458082362674934 no 1518 0.454742106459191 475 5281703 A flavanone.
SGTC_2795 7780010 54.55 µM 0.112689013165335 0.45850312427444 no 1519 0.45513855599344 479 953673
SGTC_3227 9130768 49.47 µM 0.112634167310357 0.458526199470401 no 1520 0.455160297904073 506 17720899
SGTC_1630 st005209 31.3 µM 0.11001390158002 0.459628780500453 no 1521 0.456199174985435 502 3367314
SGTC_1752 st044819 83.042 µM 0.109588523427552 0.459807804802382 no 1522 0.456367856405923 480 441209 YML126C ERG13
SGTC_2946 9065502 71.43 µM 0.109124490987977 0.460003106408372 no 1523 0.456551874943044 476 16489101
SGTC_2328 6201408 200 µM 0.108787746272492 0.460144841303336 no 1524 0.456685421594606 491 2890418
SGTC_1075 aripiprazole 15.2 µM 0.1080485289289 0.46045599352123 no 1525 0.456978598494495 483 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3213 9129884 49.47 µM 0.107000503464808 0.460897171067185 no 1526 0.457394290170973 469 17190742
SGTC_730 1436-0052 41.2 µM 0.1025770252222 0.462759805568197 no 1527 0.459149338926082 473 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_93 0109-0045 59.227 µM 0.101442545529074 0.463237644566713 no 1528 0.459599582098619 509 88733
SGTC_2906 7926292 26.41 µM 0.100413413442018 0.463671157415959 no 1529 0.4600080606008 502 2966319
SGTC_1531 st059297 52.4 µM 0.100283104656304 0.463726051934679 no 1530 0.460059785200687 500 7566702
SGTC_740 k014-0057 261 µM 0.0992103287398238 0.464178000934153 no 1531 0.46048563708571 514 4012779
SGTC_2700 st077718 96.8 µM 0.0989362305709185 0.464293482993451 no 1532 0.460594451088606 484 904970
SGTC_1811 st050069 61.5 µM 0.0971340486247956 0.465052846300844 no 1533 0.461309970902175 516 3877702
SGTC_1715 st032160 10.2275 µM 0.0962096104161862 0.465442415059356 no 1534 0.46167704910834 505 5289825
SGTC_2732 terfenadine 20 µM 0.0957867553652688 0.465620622042042 no 1535 0.461844968337494 518 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1816 st051957 91.6 µM 0.095525481824346 0.465730735962669 no 1536 0.46194872561751 510 674121
SGTC_2484 5809818 12.04 µM 0.0947268856081327 0.466067321139279 no 1537 0.462265881184671 495 2870548
SGTC_1972 st070201 17.4 µM 0.093496628568721 0.466585886265443 no 1538 0.462754513988286 501 2829099
SGTC_566 0958-0068 16.5 µM 0.093058294307206 0.466770662107413 no 1539 0.462928624964443 496 6815365
SGTC_3294 9122953 26.2835 µM 0.092650615320621 0.46694252192444 no 1540 0.463090565718424 513 16459826
SGTC_1788 fluconazole 20 µM 0.0922362357056063 0.46711721275222 no 1541 0.46325517440561 506 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3280 9140961 49.47 µM 0.0913414108878874 0.467494467370112 no 1542 0.463610657183884 478 4901226
SGTC_978 1416-0512 87.4 µM 0.0910904092509103 0.467600293929859 no 1543 0.463710376634961 499 6814003
SGTC_1441 4106-0040 13 µM 0.0909444973216181 0.467661813934259 no 1544 0.463768346458607 498 2904180
SGTC_1674 st016616 23.6 µM 0.0908683860890796 0.46769390458047 no 1545 0.463798585242409 513 625830
SGTC_2936 9038235 15.59 µM 0.0898409630502149 0.468127115625828 no 1546 0.464206797991267 506 4749415
SGTC_2081 5214970 32.255 µM 0.0889888930255551 0.46848641804918 no 1547 0.464545368590019 487 2063512
SGTC_2041 5107442 45.335 µM 0.0877920699934306 0.468991139827414 no 1548 0.465020970328789 497 793005
SGTC_2971 9092186 9.93 µM 0.0875050668205836 0.469112181661722 no 1549 0.465135029071034 497 25236400
SGTC_1793 st048256 72.231 µM 0.0858323081739718 0.469817713851442 no 1550 0.465799861516455 514 672022
SGTC_488 nitrendipine 139 µM 0.08572573713966 0.469862666365156 no 1551 0.46584222107917 519 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1736 st036774 51 µM 0.0846842425484035 0.470301997236169 no 1552 0.466256211793427 514 1272247
SGTC_1284 0929-0043 16 µM 0.0837807577253108 0.470683141119436 no 1553 0.466615373666925 504 1239883
SGTC_2992 9074591 71.4286 µM 0.0827072843124994 0.47113603123177 no 1554 0.46704214633824 513 17741321
SGTC_2630 antimycin a 100 µM 0.0826090828518778 0.47117746353942 no 1555 0.467081189446197 498 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1729 st035615 45.989 µM 0.0820383124302739 0.471418284201957 no 1556 0.467308123604251 528 17385451
SGTC_1616 st002734 56.1 µM 0.0820040489348089 0.471432741061773 no 1557 0.467321746859061 494 4026101
SGTC_1094 duloxetine 25.4 µM 0.0798371095429517 0.472347117465701 no 1558 0.46818340468209 496 60834 A selective serotonin reuptake inhibitor.
SGTC_3255 9139072 49.47 µM 0.078852083423008 0.472762814227195 no 1559 0.468575138198153 512 17646060
SGTC_2387 9077560 195.08 µM 0.0787119697495818 0.472821946856745 no 1560 0.468630862269172 503 5303272
SGTC_3220 9131269 49.47 µM 0.0771580541863803 0.473477790762491 no 1561 0.469248905018087 521 17722206
SGTC_125 0133-0007 11.75 µM 0.0765971211499163 0.473714555301489 no 1562 0.469472024608106 522 26541
SGTC_1288 0973-0013 65.5 µM 0.0748631933380162 0.474446488207213 no 1563 0.470161780902995 510 4315430
SGTC_778 3456-2434 196 µM 0.0741814023337678 0.474734312459562 no 1564 0.470433021930665 509 5539063
SGTC_17 0960-0276 49.807 µM 0.0737281300603091 0.474925672765481 no 1565 0.470613357573086 508 6821114
SGTC_2248 tofa 1.1 µM 0.0734591533828261 0.475039230781682 no 1566 0.470720373548557 520 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2260 7964312 200 µM 0.0728175248046872 0.47531012514651 no 1567 0.470975662600177 492 231951
SGTC_1710 st031758 61.5 µM 0.0721597939414057 0.475587829711376 no 1568 0.471237370755333 522 5394341
SGTC_786 4544-0069 423 µM 0.0716695975792613 0.475794806231573 no 1569 0.471432425769948 492 748821 YLR208W SEC13
SGTC_313 3474-0040 5.03 µM 0.0715180170444716 0.475858809686947 no 1570 0.471492742872968 515 1043375 YIL048W NEO1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.070938687104471 0.476103432031532 no 1571 0.471723276531009 496 75037 A free radical scavenger.
SGTC_105 0111-0055 734.78 µM 0.0701949477516824 0.47641748952002 no 1572 0.472019247759093 493 5179370
SGTC_2729 fluphenazine 10.66 µM 0.0701227208768988 0.476447989416995 no 1573 0.472047991284514 520 3372 An atypical antipsychotic.
SGTC_2756 carbadox 75.1 µM 0.0699847120032406 0.476506268058345 no 1574 0.472102913926695 520 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3198 9112019 49.47 µM 0.0698736425967553 0.476553171016901 no 1575 0.472147116000688 520 45595555
SGTC_2205 7238770 200 µM 0.0687855364075315 0.477012679157197 no 1576 0.472580165545976 509 279867
SGTC_660 4031-1742 102 µM 0.0686705605143356 0.477061235367814 no 1577 0.472625926087267 513 6738706
SGTC_1737 st035557 69.7 µM 0.0677510027455477 0.477449591930538 no 1578 0.472991924115022 522 5716916
SGTC_1128 3448-9350 235 µM 0.0671942502540345 0.477684735479192 no 1579 0.473213531206918 510 619386
SGTC_963 1269-2853 151 µM 0.066615337170536 0.477929246757326 no 1580 0.473443967785778 494 3668223
SGTC_1866 st057638 64 µM 0.0654273639357727 0.478431028225753 no 1581 0.473916868740679 506 688802
SGTC_3145 9085516 49.47 µM 0.0653319791591872 0.478471318769338 no 1582 0.473954840518954 520 25236195
SGTC_649 1123-0311 367 µM 0.0641595458024406 0.478966572636836 no 1583 0.474421594383925 521 693629 YIL048W NEO1
SGTC_638 3970-0837 4.09 µM 0.0640993472312391 0.478992002321523 no 1584 0.474445560806504 515 4118451 YLR208W SEC13
SGTC_1781 st038725 66.3 µM 0.0639277181847901 0.479064504055159 no 1585 0.474513890747171 504 4270275 YIL048W NEO1
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0634638505338115 0.479260460411666 no 1586 0.474698572143419 506 5282362
SGTC_3139 9095020 49.47 µM 0.0623387404628811 0.479735772898943 no 1587 0.475146539013268 530 25236292
SGTC_2744 captopril 92.04 µM 0.0621366887648801 0.479821134459233 no 1588 0.4752269900125 524 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1651 st011928 86.1 µM 0.0620741525023347 0.479847554583033 no 1589 0.475251890304099 507 720198
SGTC_1899 st063254 59.6 µM 0.0619207864871624 0.479912348550038 no 1590 0.475312957018378 520 3093813
SGTC_2739 tacrine 100.86 µM 0.0610022416825744 0.480300425767535 no 1591 0.475678711888976 527 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_284 0988-0104 32.6 µM 0.0603976220868412 0.480555882518974 no 1592 0.475919476250856 517 4666532
SGTC_2038 4100038 30.985 µM 0.0602834634491856 0.480604116381594 no 1593 0.47596493612342 517 3596803
SGTC_531 3788-1495 174 µM 0.0592923074266428 0.481022907621128 no 1594 0.476359644060583 504 2896655
SGTC_2166 5933061 31.504 µM 0.0586436640811827 0.481296989008385 no 1595 0.476617965799626 500 2877375
SGTC_748 act1.228 77.9 µM 0.057688655606097 0.481700539684804 no 1596 0.476998315081252 518 4421505 YNR035C ARC35
SGTC_1024 4507-0395 26 µM 0.0571637208727463 0.481922365380095 no 1597 0.477207388715991 503 4201836
SGTC_2347 9049783 174.81 µM 0.0568413898929165 0.482058578031662 no 1598 0.477335771425639 514 6467988 YPL169C MEX67
SGTC_1813 st051246 8.6015 µM 0.0560955097235359 0.482373784766184 no 1599 0.477632860514768 523 5291959
SGTC_2446 5162541 200 µM 0.0534675680394051 0.483484431560559 no 1600 0.478679685313647 525 1549321
SGTC_2676 harmalol 100 µM 0.0524410619833841 0.48391829902125 no 1601 0.479088628189888 511 5459187 A monoamine oxidase inhibitor
SGTC_912 3474-0017 2.18 µM 0.0510526066159728 0.484505179734641 no 1602 0.479641800575513 522 3360550
SGTC_945 3381-0768 11.3 µM 0.0502279904773776 0.484853749441991 no 1603 0.479970353262004 532 1126236 YIL048W NEO1
SGTC_2819 7996655 46.38 µM 0.0500134083742993 0.484944456367572 no 1604 0.480055851678281 528 6456960
SGTC_761 k216-0224 480 µM 0.0498787330652157 0.4850013859461 no 1605 0.48010951238014 526 1340404
SGTC_2149 5554786 194.827 µM 0.0495470250603745 0.485141605948591 no 1606 0.480241681307283 516 745063 YPR165W RHO1
SGTC_2300 7976697 71.57 µM 0.0492095114571936 0.485284281986228 no 1607 0.480376165702362 531 2236109
SGTC_301 4119-0100 24.5 µM 0.0482534752705077 0.485688434247583 no 1608 0.480757116342807 523 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3339 9145883 14.936 µM 0.0480240553187919 0.485785420846567 no 1609 0.480848535675053 536 2030670
SGTC_2802 7925815 54.55 µM 0.0466991061296308 0.486345555428413 no 1610 0.481376521387738 518 1262923
SGTC_2441 5730946 39.09 µM 0.0465999171641192 0.486387489582893 no 1611 0.481416049026838 523 1774275
SGTC_2693 st077581 40.7 µM 0.046257295104873 0.486532341188639 no 1612 0.48155258820948 525 25238761
SGTC_2585 alliin 100 µM 0.045727258323996 0.486756430308935 no 1613 0.481763818763997 536 87310 A garlic compound which reacts with lipids.
SGTC_2056 5235370 200 µM 0.0454159795723986 0.486888034792989 no 1614 0.481887872136283 506 5511916
SGTC_2409 alverine citrate 63.97 µM 0.0446965858821831 0.487192190242534 no 1615 0.482174577525836 462 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_795 0685-0265 78 µM 0.0445923848702784 0.487236246443506 no 1616 0.482216106308365 523 302754
SGTC_2136 5328288 199.296 µM 0.0443841628128095 0.487324283221746 no 1617 0.482299092726374 529 262395
SGTC_810 3825-7150 143 µM 0.044342269055342 0.487341996076241 no 1618 0.482315789479028 514 22330411 YGL099W LSG1
SGTC_2426 5582046 32.21 µM 0.0435676278709683 0.487669522046148 no 1619 0.482624528200407 521 2251934
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0431287189036126 0.487855100812515 no 1620 0.48279946310914 518 16725076
SGTC_580 1123-0028 41 µM 0.0428967140979506 0.487953197767113 no 1621 0.48289193405563 532 1677248 YPR107C YTH1
SGTC_1608 st001473 40.5 µM 0.0424559466261953 0.488139566369197 no 1622 0.483067614780709 535 7292267
SGTC_251 melphalan 456.522 µM 0.042334307789979 0.488190999070264 no 1623 0.483116098065163 525 460612 A DNA alkylator.
SGTC_426 0988-0037 14.6 µM 0.0422297130594531 0.488235225147906 no 1624 0.483157788042784 533 5383008
SGTC_2516 gossypol 71.55 µM 0.0416170994989743 0.488494261112341 no 1625 0.48340197081108 521 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2004 4023728 41.89 µM 0.0407304884805139 0.488869162033548 no 1626 0.483755377731977 533 360084 YDR527W RBA50
SGTC_2445 5742597 35.57 µM 0.0404126286277221 0.489003570571117 no 1627 0.48388208114288 532 1774255
SGTC_3345 9148410 3.559 µM 0.0400873599179339 0.489141113271529 no 1628 0.484011739513284 533 4903596
SGTC_1605 st000082 49.1 µM 0.0388708458518542 0.48965553812993 no 1629 0.484496680317511 524 1114022
SGTC_2477 5967686 25.23 µM 0.0383405685224407 0.489879780874339 no 1630 0.484708072773642 522 776118
SGTC_3228 9131799 49.47 µM 0.0378859914395874 0.490072014180802 no 1631 0.484889291121435 509 17015818
SGTC_2226 7298446 200 µM 0.0368814942806003 0.490496807920186 no 1632 0.485289747566286 533 3283010
SGTC_1950 st077106 7.18 µM 0.0361174711877349 0.490819914361274 no 1633 0.485594345711551 516 13831864
SGTC_1204 4049-0315 18.3 µM 0.0360736082277788 0.490838464253629 no 1634 0.485611833105051 516 588402
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0352556662966079 0.491184380081285 no 1635 0.485937937252508 534 4114 Related to psoralen; DNA damaging agent.
SGTC_3212 9128307 49.47 µM 0.0350405182549705 0.491275369452992 no 1636 0.486023715901356 505 27243542
SGTC_1682 st012968 530 nM 0.0350046070806828 0.491290556877895 no 1637 0.486038033603522 517 24207270
SGTC_2614 arthonioic acid 13.39 µM 0.0344961784778367 0.491505581021764 no 1638 0.486240744834614 531 6710684
SGTC_2115 tiliquinol 12.7705 µM 0.0344054951162689 0.491543933004472 no 1639 0.486276900799256 536 71208 A bioactive hydroxyquinoline.
SGTC_2137 5261020 140 µM 0.0342897522410715 0.491592883318677 no 1640 0.486323048296303 525 763655
SGTC_392 N-ethylmaleimide 8.33 µM 0.0341209312085702 0.491664281828722 no 1641 0.486390358755588 523 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2381 9035592 200 µM 0.0341054150241541 0.491670844012952 no 1642 0.486396545216916 513 4749657
SGTC_2404 5161160 200 µM 0.03368239865041 0.491849749128092 no 1643 0.486565207425306 528 2831543
SGTC_1172 0370-0043 85 µM 0.0333513042862288 0.491989779074101 no 1644 0.486697220794004 528 376585
SGTC_3170 9103054 49.47 µM 0.0327974425362772 0.49222402636777 no 1645 0.486918058838763 525 16432970
SGTC_2462 5162487 171.77 µM 0.0322711519801255 0.492446615335774 no 1646 0.48712790730132 534 2259986
SGTC_2540 epiandrosterone 100 µM 0.0321503249190534 0.492497718184862 no 1647 0.487176085324973 530 441302 A steroid.
SGTC_1035 k081-0041 55.2 µM 0.0319082834137981 0.492600088093195 no 1648 0.487272596397885 536 731709
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0313664939714951 0.492829236232865 no 1649 0.487488630966663 538 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_642 0335-0876 158 µM 0.0306685055691138 0.493124451708454 no 1650 0.487766954128438 536 6812350
SGTC_3120 9124077 49.47 µM 0.0296550478422226 0.493553102173839 no 1651 0.48817108138209 528 18774327 YGL155W CDC43
SGTC_1818 st052136 56.3 µM 0.029283776857206 0.493710136247357 no 1652 0.488319132773351 534 674169
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.027606261343004 0.494419675868521 no 1653 0.488988093870235 529 15053
SGTC_3045 9092950 49.47 µM 0.0274898135999256 0.494468930512929 no 1654 0.489034532174152 525 44120432
SGTC_233 rapamycin 362 pM 0.0272215041408744 0.494582419395406 no 1655 0.489141532118043 535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_466 geldanamycin 89.2 µM 0.027079348716841 0.494642548129232 no 1656 0.48919822302845 536 5288382 HSP90 inhibitor.
SGTC_1044 1222-0021 1.78 µM 0.0264465294802649 0.494910218722462 no 1657 0.489450590977485 528 4306703
SGTC_2420 aureobasidin a 50 nM 0.0260533992179667 0.495076506565124 no 1658 0.489607373234266 515 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3334 9142812 21.919 µM 0.025891293652878 0.495145074889336 no 1659 0.48967202218943 523 45283678
SGTC_1353 1498-1206 8.11 µM 0.0257840883340796 0.495190421277328 no 1660 0.489714776650235 535 6756808
SGTC_459 nigericin 15.3 µM 0.024576313158717 0.495701297862619 no 1661 0.490196456476688 531 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2253 7938677 135.83 µM 0.0241978714882822 0.495861376320865 no 1662 0.490347387970352 521 2301972
SGTC_1921 5740136 50 µM 0.0236444983367197 0.496095450893379 no 1663 0.490568088760456 538 1774243
SGTC_1047 2043-3044 82 µM 0.0236098124692143 0.49611012291862 no 1664 0.49058192255769 537 669592
SGTC_2649 anisomycin 9.56 µM 0.0226763905649752 0.496504959693134 no 1665 0.490954204296247 539 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1927 st060202 13.8 µM 0.0224709115482225 0.496591877638405 no 1666 0.491036157680479 541 688887
SGTC_215 1287-0124 461.5 µM 0.0221674633449167 0.496720236997401 no 1667 0.491157185849613 536 5560863
SGTC_229 benomyl 22.8748 µM 0.0213781791876926 0.497054107753077 no 1668 0.491471990036801 523 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_522 1273-0010 11.6 µM 0.0211440109120307 0.497153162396475 no 1669 0.491565388550433 538 5705015
SGTC_1726 st035556 14.5795 µM 0.018574379793893 0.498240142607853 no 1670 0.492590320636362 507 5919439
SGTC_647 0140-0236 81 µM 0.0185259971288408 0.498260609120021 no 1671 0.492609619206392 533 990837
SGTC_3193 9111931 49.47 µM 0.0179343348626545 0.498510890498359 no 1672 0.492845619077416 531 17087244
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0167461792089181 0.499013498556936 no 1673 0.493319553317817 540 147795
SGTC_1261 0712-0010 12.7 µM 0.0159729817096985 0.499340573844837 no 1674 0.493627973208799 542 2840123
SGTC_1912 st060209 90.8 µM 0.0151618057855257 0.499683715105114 no 1675 0.493951546362584 542 688787
SGTC_2804 7954240 19.48 µM 0.0149828038061624 0.499759436037811 no 1676 0.494022949709367 540 828705
SGTC_1224 0823-0416 294 µM 0.0149225416600875 0.499784927969781 no 1677 0.494046988139905 536 3598164
SGTC_1888 azatryptophan 97.5 µM 0.0145558838439446 0.499940030594324 no 1678 0.494193247556503 527 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2504 purpurogallin 52.29 µM 0.014272352214186 0.499940030594324 no 1679 0.494306348561139 528 5281571 An antioxidant.
SGTC_3009 9080819 71.4286 µM 0.0141334384076391 0.499881267639089 no 1680 0.494361761562558 538 17027216
SGTC_2681 menadione 3.18 µM 0.013304002061516 0.499530401742207 no 1681 0.494692627643938 546 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_430 0958-0115 16.4 µM 0.0125237788113974 0.499200354161381 no 1682 0.495003865725222 534 6833180
SGTC_421 streptovitacin 30 mM 0.0124090817037301 0.499151835393027 no 1683 0.495049619695392 535 91467 include heat shock
SGTC_3199 9111318 49.47 µM 0.0123555280272869 0.499129181308831 no 1684 0.495070982883413 540 8548020
SGTC_2705 st078069 42.8 µM 0.0118582478004763 0.498918823753984 no 1685 0.495269354450191 539 1530061
SGTC_2791 5663188 71.43 µM 0.0111753448828777 0.498629945309385 no 1686 0.495541775225056 545 54690634
SGTC_1849 st056239 19.2 µM 0.0106003997051858 0.498386735201142 no 1687 0.495771131567177 542 5393181
SGTC_1753 st043925 64 µM 0.00883127878173474 0.497638375670606 no 1688 0.496476875299635 545 670181
SGTC_381 3461-2219 42.7 µM 0.00829536670259949 0.497411679903852 no 1689 0.496690665445209 542 2883159
SGTC_797 k781-0471 270 µM 0.00829305759130868 0.497410703130172 no 1690 0.496691586615647 541 23738129
SGTC_600 1495-0418 41.6 µM 0.0076357271039325 0.49713264740707 no 1691 0.496953815217623 544 5377768
SGTC_451 chloral hydrate 100 µM 0.00737493427541495 0.497022330464295 no 1692 0.497057853572768 541 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3142 9086498 49.47 µM 0.00680536091910324 0.496781398295162 no 1693 0.497285074752021 545 25236367
SGTC_2234 tolnaftate 200 µM 0.00676410371631942 0.496763946351741 no 1694 0.497301533615755 545 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1607 st000305 50.6 µM 0.00633098296458731 0.496580735114432 no 1695 0.497474320091044 544 5457690
SGTC_1683 st010134 710 nM 0.00515437134832064 0.496083029003571 no 1696 0.497943712445354 541 3818134
SGTC_2340 7987427 183.45 µM 0.00503067698429259 0.496030706691696 no 1697 0.497993058717109 544 2239331
SGTC_1398 3558-0053 112 µM 0.00488573321811369 0.495969396039082 no 1698 0.498050882202903 544 4532369
SGTC_2238 6671620 73.2395 µM 0.00318228524833025 0.495248851657991 no 1699 0.498730454008913 545 729941
SGTC_245 methotrexate 289.6 µM 0.000965286252299822 0.494311103014163 no 1700 0.499614906561071 547 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1526 st051518 75 µM 0.000944367034758948 0.494302254722365 no 1701 0.499623252117616 547 673993
SGTC_2309 7664088 163.95 µM 0.00061819515747485 0.494164292759968 no 1702 0.499753375829852 547 704922
SGTC_664 1222-0054 14.9 µM 0.000508250820927291 0.494117789408683 no 1703 0.499797237267213 547 6813991
SGTC_2761 levamisole 97.89 µM 0.000412846074763466 0.494077435958521 no 1704 0.499835298250158 546 26879 An alkaline phosphatase inhibitor.
SGTC_826 1683-5028 118 µM 5.41456289100483e-06 0.493905104892046 no 1705 0.499997839901933 548 722377
SGTC_2099 5377090 177.372 µM -0.000167151092135493 0.49383211523968 no 1706 0.499933316362442 548 2243829
SGTC_1697 st025554 27.742 µM -0.000437331884324208 0.493717837978859 no 1707 0.499825529826337 549 1269519
SGTC_3036 9090181 49.47 µM -0.00157915189932789 0.493234892858027 no 1708 0.499370009802019 550 25236586
SGTC_315 k915-0449 187 µM -0.00273240561601245 0.492747121797006 no 1709 0.498909929228985 551 20970215 YNL149C PGA2
SGTC_2878 9043973 25.97 µM -0.00300586607806144 0.492631462688526 no 1710 0.498800834738026 552 6465167
SGTC_959 1222-0044 107 µM -0.00319323883914103 0.492552214417323 no 1711 0.498726084180619 550 6083612
SGTC_2812 7970281 58.44 µM -0.00385178986998835 0.492273686260359 no 1712 0.498463361965307 552 2233435
SGTC_363 0455-0021 3.06 µM -0.00394979564201167 0.492232235930955 no 1713 0.498424263616604 551 4597466
SGTC_819 1013-0258 27.7 µM -0.00412207410489104 0.492159373088943 no 1714 0.498355535013599 552 5753198
SGTC_2080 5212524 12.4 µM -0.00432267771166207 0.492074530840877 no 1715 0.498275506466787 552 260183
SGTC_1032 k061-1018 98.7 µM -0.00441182107366779 0.492036829124951 no 1716 0.498239943749821 554 4005393
SGTC_1617 st002906 78 µM -0.00462454676341878 0.491946860588135 no 1717 0.498155079344426 550 5150859
SGTC_3092 9117248 49.47 µM -0.00478582147993225 0.491878652595679 no 1718 0.498090740753511 551 17141857
SGTC_3235 9132602 49.47 µM -0.00561408142012505 0.491528360010458 no 1719 0.497760317320922 557 4912240
SGTC_2720 fluspirilene 36.88 µM -0.00621587155592027 0.491273851454831 no 1720 0.497520241995235 553 3396 An atypical antipsychotic.
SGTC_326 k292-0812 17.5 µM -0.00639106053420086 0.49119976134905 no 1721 0.497450353093314 552 3579357
SGTC_54 0159-0055 9 µM -0.00722059702327564 0.490848941811071 no 1722 0.497119423588475 552 3319099
SGTC_216 k038-0035 28.382 µM -0.00723891309414259 0.490841195834647 no 1723 0.497112116724361 552 4444231 YPR107C YTH1
SGTC_1324 1418-0026 34.4 µM -0.00807629456407217 0.490487065914686 no 1724 0.496778059655454 571 1372513
SGTC_2242 6630449 61.2675 µM -0.00820857929209122 0.490431123177109 no 1725 0.496725287433843 570 691249 YDR170C SEC7
SGTC_2953 9074162 66.49 µM -0.00824373616981192 0.490416255491084 no 1726 0.496711262343419 552 16451992
SGTC_2543 pimpinellin 60.67 µM -0.0085536150037469 0.490285209699259 no 1727 0.49658764293525 557 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2351 9026858 72.31 µM -0.00968545342728146 0.48980657143086 no 1728 0.496136123533519 560 1409300
SGTC_1235 benzylparaben 21.5 µM -0.0107227202139094 0.489367939027478 no 1729 0.495722335517892 554 7180
SGTC_1309 pyrazolanthrone 13.4 µM -0.0107943392928 0.48933765370151 no 1730 0.495693765292737 557 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1985 st071382 65.5 µM -0.0119030505408616 0.488868824546971 no 1731 0.495251482004166 571 6123237
SGTC_320 4092-0846 5.34 µM -0.0120843523040769 0.488792160808476 no 1732 0.495179158267438 557 1359356
SGTC_3184 9108758 49.47 µM -0.0121477023029126 0.488765373258346 no 1733 0.495153887129389 553 902885
SGTC_2012 4023501 200 µM -0.0122238253500746 0.48873318469115 no 1734 0.495123520682054 558 3477460
SGTC_1108 betulinic acid 729.144 nM -0.0125427465354725 0.488598329933287 no 1735 0.494996299292427 556 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1080 nisoldipine 24.4 µM -0.0126215998880917 0.488564987256941 no 1736 0.494964843846096 554 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_723 4182-0001 115 µM -0.0133701861858869 0.488248455957614 no 1737 0.49466622634665 562 744821 YLR208W SEC13
SGTC_780 0109-0199 192 µM -0.0135826581412725 0.488158615920143 no 1738 0.494581469997224 557 610414
SGTC_1162 k048-0130 20.1 µM -0.0153225621614973 0.487422951057411 no 1739 0.493887421296768 567 6797406
SGTC_3287 9117173 37.0625 µM -0.0160848814153134 0.487100641158933 no 1740 0.493583337419519 551 2789709
SGTC_2928 9011484 9.79 µM -0.0171077199633892 0.486668196526383 no 1741 0.49317534008714 559 2994751
SGTC_948 3448-0295 75.3 µM -0.017377305339953 0.486554221451206 no 1742 0.493067807068775 558 678569
SGTC_2703 st077852 53.4 µM -0.0187566145052198 0.485971095685191 no 1743 0.49251763216862 559 6281836
SGTC_648 0375-0473 33.3 µM -0.0196354984601071 0.48559954852227 no 1744 0.492167072805242 558 1713139
SGTC_568 1193-0097 7.48 µM -0.0197139837451462 0.485566369563178 no 1745 0.492135767766264 562 3646150
SGTC_2695 st077686 51.995 µM -0.0204574798269771 0.485252068168718 no 1746 0.491839215576778 561 2876092
SGTC_1458 k015-0034 6.33 µM -0.0206236674474156 0.485181816185165 no 1747 0.49177293029344 574 3598957
SGTC_2882 9058044 58.44 µM -0.0206358772587831 0.48517665478713 no 1748 0.49176806031986 564 18076804
SGTC_1265 0819-1001 68.8 µM -0.0217103781548341 0.484722445733698 no 1749 0.491339492577222 565 3106768
SGTC_888 0916-0002 6.97 µM -0.0221584955929704 0.484533025007388 no 1750 0.491160762586475 564 2802138 YIL048W NEO1
SGTC_1055 3448-0672 86 µM -0.0237555655251399 0.483857966937082 no 1751 0.490523791805412 562 748378
SGTC_1192 1488-0095 21.4 µM -0.0250829690137108 0.483296928047996 no 1752 0.489994392333671 567 915875
SGTC_2199 6590217 200 µM -0.025745515376551 0.483016909239164 no 1753 0.489730159927123 559 703109
SGTC_1471 k673-0312 37 µM -0.0258633478594076 0.48296710935397 no 1754 0.489683167215826 557 24099884
SGTC_1642 st009582 77.7 µM -0.0262236153945445 0.482814850088591 no 1755 0.489539489998309 562 6739311
SGTC_3247 9135149 49.47 µM -0.0262481345747942 0.482804487679322 no 1756 0.489529711626536 557 8934436 YOR116C RPO31
SGTC_138 0850-0259 40.9225 µM -0.0264918787158239 0.482701476036838 no 1757 0.489432505586631 565 6813004
SGTC_2322 7413319 38.22 µM -0.0269913892239853 0.48249037550999 no 1758 0.48923330096733 558 1840400
SGTC_236 1509-0011 5.31 µM -0.0280437482667194 0.482045649154093 no 1759 0.488813629391601 569 3107280
SGTC_799 1310-0557 151 µM -0.028837625368715 0.481710171878738 no 1760 0.488497046322073 577 5354492
SGTC_2090 5301565 104.445 µM -0.0293829011494409 0.481479756254029 no 1761 0.48827960491161 569 2056344
SGTC_2233 sulbentine 40.3845 µM -0.0294968674175308 0.481431598633687 no 1762 0.488234158647314 563 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2859 9028643 45.46 µM -0.0296163512812673 0.481381109787449 no 1763 0.48818651229858 564 17151580
SGTC_2566 crystal violet carbinol 226 nM -0.0297023207342856 0.481344782903709 no 1764 0.488152230530703 561 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_644 1498-1197 63.3 µM -0.0300915529570642 0.48118031254608 no 1765 0.487997018722864 569 6741615
SGTC_189 3970-0742 2.116 µM -0.030411694516701 0.481045038897856 no 1766 0.487869359147438 561 2891807
SGTC_2764 methyldopa 94.69 µM -0.030536434425223 0.480992331484212 no 1767 0.487819618225687 563 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1519 esterone 74 µM -0.0310809743723837 0.48076224629606 no 1768 0.487602481295146 566 698 A steroid.
SGTC_1377 2944-0135 198 µM -0.0315296229167253 0.480572683041789 no 1769 0.487423584106314 565 1894137
SGTC_576 1073-0113 22.7 µM -0.0324486491414866 0.480184389288823 no 1770 0.48705713324479 566 5439563
SGTC_676 falcarinol 140 µM -0.03280047600092 0.480035745417015 no 1771 0.486916849312223 568 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_968 1309-0633 340 µM -0.0340302314454912 0.479516206090293 no 1772 0.486426521724565 558 3761976
SGTC_3277 9138724 49.47 µM -0.0344983974839158 0.479318427351924 no 1773 0.486239860105867 569 15943418
SGTC_1007 4101-0031 70 µM -0.0349684225075401 0.479119868399788 no 1774 0.486052460327383 584 1146276
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0376374363890648 0.477992460905377 no 1775 0.484988379567212 562 688669
SGTC_2628 lathosterol 100 µM -0.0378454673838825 0.477904594644704 no 1776 0.484905446294723 569 6710616
SGTC_3089 9117425 49.47 µM -0.0378825329689231 0.477888939328848 no 1777 0.484890669861857 560 9401657
SGTC_3052 9092717 49.47 µM -0.0379918821785153 0.477842753924229 no 1778 0.48484707722009 573 25237534
SGTC_2144 5628481 200 µM -0.0388285742411495 0.477489373414172 no 1779 0.484513531528714 555 2818399
SGTC_936 3005-4620 401 µM -0.0393151464292915 0.477283875668337 no 1780 0.484319565424153 559 777207
SGTC_2055 5235184 200 µM -0.0393745510718509 0.477258787264901 no 1781 0.484295884736737 569 2836034
SGTC_787 4152-0075 138 µM -0.0404460896797902 0.476806259202393 no 1782 0.483868743019721 563 9566539
SGTC_2213 7173844 200 µM -0.0407020475397346 0.476698168467203 no 1783 0.48376671462462 563 892728
SGTC_1057 3448-5381 134 µM -0.0415901292754153 0.476323145828438 no 1784 0.483412721065945 571 5497911
SGTC_3205 9113483 49.47 µM -0.0432668123292189 0.475615166970528 no 1785 0.482744423180574 576 17018033
SGTC_1060 3448-7350 82 µM -0.0445037083761182 0.475092937244641 no 1786 0.482251448025426 577 570178
SGTC_1310 1188-0297 994 nM -0.0446827400762804 0.475017351816507 no 1787 0.48218009569012 565 1588352
SGTC_1004 4084-0029 199 µM -0.0448507766651647 0.474946409234484 no 1788 0.482113125929668 570 716894 YLR208W SEC13
SGTC_3083 9117465 49.47 µM -0.0470050684621004 0.474036970004147 no 1789 0.481254593973583 578 16420915
SGTC_53 0973-0023 39.979 µM -0.0486001548326441 0.473363687532298 no 1790 0.480618973286954 572 674768
SGTC_2270 7924575 90.91 µM -0.0488578763709964 0.473254910923397 no 1791 0.480516279265773 601 1262135
SGTC_2753 fluvastatin 17.09 µM -0.0489779562451571 0.473204229454584 no 1792 0.48046843161006 575 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1438 4092-1045 4 µM -0.0501962119246495 0.472690071474685 no 1793 0.479983015098372 564 1351342
SGTC_76 0433-0009 400.328 µM -0.0503061820731728 0.472643661416259 no 1794 0.479939198713696 596 2841569
SGTC_2751 anetholtrithion 17.25 µM -0.0515282963078729 0.472127924834868 no 1795 0.479452277301298 581 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_467 ro 31-8220 72.8 µM -0.052276761041996 0.471812093055498 no 1796 0.479154084997056 583 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0523016701582557 0.471801582388965 no 1797 0.479144161273225 575 5377381
SGTC_943 3253-1379 105 µM -0.0530551003825668 0.471483673806776 no 1798 0.478844002869195 570 668464
SGTC_742 0kpi-0133 140 µM -0.0531649866287591 0.471437309008346 no 1799 0.478800226382792 578 2728852
SGTC_2016 5121758 140 µM -0.0540152173521951 0.471078580465318 no 1800 0.478461520123758 582 2795203
SGTC_1328 1441-0025 69.2 µM -0.0554209972926721 0.470485506733706 no 1801 0.477901534061503 581 4562601
SGTC_1834 st055981 52.8 µM -0.0557027027820617 0.470366667993528 no 1802 0.477789323169477 571 471719 YDL150W RPC53
SGTC_1847 st056231 15 µM -0.0563044835759784 0.47011281288642 no 1803 0.477549623562973 581 5393180
SGTC_1120 ficusin 1.78878 µM -0.0572485879100263 0.469714576590661 no 1804 0.477173587020662 587 6199 A DNA cross-linker.
SGTC_2050 5263056 171 µM -0.0578028144017612 0.469480810259068 no 1805 0.476952848180517 584 763468 YGL055W OLE1
SGTC_2666 tannic acid 100 µM -0.0581626989099967 0.469329020759147 no 1806 0.476809516178617 567 16134267 A thiamine antagonist.
SGTC_3086 9117350 49.47 µM -0.0584253261548219 0.469218254540503 no 1807 0.47670492093539 575 2679265
SGTC_3143 9086658 49.47 µM -0.0589306109512528 0.469005151271446 no 1808 0.476503688199577 587 25236626
SGTC_2289 7946404 165.07 µM -0.0591371868202782 0.468918030695154 no 1809 0.476421419829112 580 1246120 YPR165W RHO1
SGTC_2125 5246583 200 µM -0.0616573662799047 0.4678553002047 no 1810 0.475417846057624 581 835267
SGTC_686 1319-0111 510 µM -0.0618410088135146 0.4677778691374 no 1811 0.475344722827618 575 4562600
SGTC_2957 9076800 11.52 µM -0.0620097846210129 0.467706707553896 no 1812 0.47527751999897 587 16459615
SGTC_2439 5492030 7.2 µM -0.0630848499834779 0.4672534479879 no 1813 0.474849469114963 578 5722370
SGTC_1762 st045503 25.4615 µM -0.0633530837752594 0.467140364220332 no 1814 0.474742672940896 583 4645554
SGTC_2734 clemastine 41.6 µM -0.0638677483989262 0.466923395954665 no 1815 0.474537766439236 581 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2319 6033012 152.6 µM -0.0649499172455006 0.466467215856022 no 1816 0.474106938125389 578 847246
SGTC_871 0574-0004 149 µM -0.0682017019180968 0.465096718043676 no 1817 0.472812536096698 576 9551173
SGTC_2532 xanthone 78.9 µM -0.0685717125955031 0.464940799195248 no 1818 0.472665267964571 589 7020 An insecticide.
SGTC_2926 9010726 65.15 µM -0.0698590915906111 0.464398352487902 no 1819 0.472152906861509 611 2994293
SGTC_2073 5212005 126 µM -0.0700026574599919 0.464337864024121 no 1820 0.472095772240673 578 691789
SGTC_2721 ifenprodil 61.44 µM -0.0700180612255824 0.464331374019948 no 1821 0.472089642069092 588 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1784 st039334 36.3 µM -0.0702321011886168 0.464241194439831 no 1822 0.472004462173213 578 3496984
SGTC_1524 corynanthine 62.1 µM -0.0703081741170853 0.464209143742401 no 1823 0.471974188302562 625 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2129 girgensonine 121.053 µM -0.0709442824595158 0.463941150602553 no 1824 0.471721049917296 583 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_422 cantharidin 155 µM -0.0715893849336749 0.463669384934404 no 1825 0.471464343997799 573 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1233 0325-0408 14.2 µM -0.0722947390219792 0.46337225616141 no 1826 0.47118367569762 596 12874
SGTC_2336 9001819 198.65 µM -0.0724260106540888 0.463316960541093 no 1827 0.471131442818849 569 2989602
SGTC_1425 4048-4433 7.33 µM -0.0738525736549014 0.462716094564955 no 1828 0.470563846739008 577 23734946
SGTC_3332 9141069 11.198 µM -0.0740875933311654 0.462617112790713 no 1829 0.470470343608481 592 17332883
SGTC_726 3448-4391 34.2 µM -0.074210102790943 0.46256551716147 no 1830 0.470421603577199 583 1356692
SGTC_2184 6075246 200 µM -0.0742221658560283 0.462560436759814 no 1831 0.470416804345888 577 2267320
SGTC_645 0845-0943 5.41 µM -0.0751203711789836 0.462182171690467 no 1832 0.470059469880479 588 1885106
SGTC_2909 7941780 10.49 µM -0.0761998131405704 0.461727626935214 no 1833 0.469630065675493 599 1243215
SGTC_2371 9071574 200 µM -0.0765580744789135 0.461576776844323 no 1834 0.469487556369128 578 45596039
SGTC_1165 k072-0275 30.3 µM -0.0772590135192696 0.46128165434036 no 1835 0.469208747941499 580 6153523 YGL055W OLE1
SGTC_13 0199-0087 65 µM -0.0795966846723626 0.460297559211637 no 1836 0.468279016050068 579 4589825
SGTC_668 1682-0499 62.6 µM -0.0799882194707952 0.460132757461056 no 1837 0.468123312724239 576 682214
SGTC_3078 9116413 49.47 µM -0.0816436286910875 0.459436051645768 no 1838 0.467465053200311 585 17177322
SGTC_1930 st074634 34.3 µM -0.0830650399791762 0.458837926961147 no 1839 0.466899911901155 602 684253 YOR116C RPO31
SGTC_286 k060-0067 22.9 µM -0.0832447828069583 0.458762298442972 no 1840 0.466828452377224 595 5985051
SGTC_1476 4112-3294 3.34 µM -0.0833742753886013 0.458707814122507 no 1841 0.466776971273509 575 704369
SGTC_500 h-89 112 µM -0.0841417763888636 0.458384902157346 no 1842 0.466471854819028 600 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0841869686662866 0.458365889189761 no 1843 0.466453889451745 592 4330530
SGTC_894 0960-0238 55.9 µM -0.0853833985154107 0.457862570666399 no 1844 0.465978295513396 574 6741907 YDL195W SEC31
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0858537645639181 0.457664713799772 no 1845 0.465791333136213 600 23847180
SGTC_1600 coumarin 106 71.1 µM -0.0863654622346922 0.457449482932098 no 1846 0.465587950728849 606 100336 A hepatotoxic, DNA x-linker.
SGTC_2272 7805186 180 µM -0.0882739394063794 0.456646847619041 no 1847 0.464829475711114 578 2956062 YPR165W RHO1
SGTC_2600 tangeritin 87.95 µM -0.0893857252237861 0.456179352697131 no 1848 0.464387683839642 604 68077 A bioactive flavone.
SGTC_2549 cedrol 20.94 µM -0.0910680452444374 0.455472069333605 no 1849 0.463719261653664 584 6708665 A sedative which affects the nervous system.
SGTC_2014 4013930 200 µM -0.0914814400272244 0.455298290825095 no 1850 0.463555026552112 607 64556
SGTC_2292 7671323 168.05 µM -0.0918418587823759 0.455146788794565 no 1851 0.463411843041771 602 937504
SGTC_214 4373-3496 70 µM -0.0937516271749131 0.454344126995871 no 1852 0.462653229142298 596 3779166
SGTC_2331 7980721 200 µM -0.0938175923084758 0.454316405640612 no 1853 0.462627028340502 599 2981221
SGTC_2152 5568786 200 µM -0.095733434914664 0.453511384706263 no 1854 0.46186614281182 606 5399883
SGTC_933 2914-0560 114 µM -0.0957766971972224 0.453493208451993 no 1855 0.461848962601936 607 463887
SGTC_2767 sibutramine 71.45 µM -0.0960549186245788 0.453376318580973 no 1856 0.461738477704102 614 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1885 st057546 99.9 µM -0.0966106538897029 0.453142848222291 no 1857 0.461517797747845 598 702008
SGTC_5 0352-0601 109.883 µM -0.0967476821320682 0.45308528367065 no 1858 0.461463386271791 607 762456
SGTC_511 blebbistatin 171 µM -0.0982299268805463 0.452462666868951 no 1859 0.460874859579438 607 3476986 A myosin inhibitor.
SGTC_103 0844-0104 51.839 µM -0.100750184793695 0.451404301817223 no 1860 0.459874386155478 589 5375804
SGTC_3271 9137798 49.47 µM -0.101115354448434 0.451250979787767 no 1861 0.459729444714953 589 6498326
SGTC_715 0868-0130 184 µM -0.101542639291192 0.451071586987377 no 1862 0.459559855599024 601 2876258
SGTC_2167 5876490 200 µM -0.102071807114627 0.450849433126511 no 1863 0.459349839386966 593 686534
SGTC_181 1447-1644 8.07 µM -0.102539119009697 0.450653260260048 no 1864 0.459164381995849 607 534600
SGTC_2020 4017018 200 µM -0.103104565639808 0.450415907533465 no 1865 0.458939990740776 596 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1996 st072960 66.8 µM -0.103449008479801 0.450271332375252 no 1866 0.45880330880779 596 1719405
SGTC_2278 7948257 134.34 µM -0.103959574663392 0.450057041367901 no 1867 0.458600714713891 583 1247028
SGTC_2537 larixol 68.93 µM -0.104351434575244 0.449892582739373 no 1868 0.458445230892441 593 6708759
SGTC_3025 9087895 49.47 µM -0.104423307492623 0.449862419521792 no 1869 0.45841671354375 598 17173641
SGTC_1902 st060212 70.5 µM -0.105733901532668 0.449312447834311 no 1870 0.45789674078741 591 688944
SGTC_1978 st071761 42 µM -0.107217008443747 0.44869020111736 no 1871 0.457308411210661 588 5147680
SGTC_671 0560-0003 407 µM -0.107527203454885 0.448560072779987 no 1872 0.457185372596035 610 3238678
SGTC_480 am 92016 50 µM -0.107910947903762 0.448399097750059 no 1873 0.457033166333028 645 2129 K+ channel blocker.
SGTC_115 0527-0192 112.043 µM -0.108322047975105 0.44822665687402 no 1874 0.456870116881449 611 4233931
SGTC_3163 9099914 49.47 µM -0.109308374997646 0.447812970077256 no 1875 0.45647895205699 590 16268368
SGTC_1513 0337-0559 19 µM -0.10978043267002 0.447614998976759 no 1876 0.456291754851729 586 775073
SGTC_1663 st014140 55.4 µM -0.110296100737013 0.447398753504997 no 1877 0.45608727477974 617 4207120
SGTC_812 4251-0442 148 µM -0.11068781138607 0.447234500038569 no 1878 0.45593195584422 621 5723007
SGTC_354 2783-3500 4.88 µM -0.110782231389818 0.447194908868011 no 1879 0.455894517954012 597 6740761
SGTC_2171 5739187 198.077 µM -0.111103121135849 0.447060360799883 no 1880 0.455767286879484 591 2262761
SGTC_2885 9057732 51.95 µM -0.111997270981982 0.446685478753262 no 1881 0.455412785199485 618 6471414
SGTC_3319 9138450 16.7555 µM -0.112297463302848 0.446559630523433 no 1882 0.455293776536825 618 2029690
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.112764950953891 0.446363658572372 no 1883 0.455108453072334 589 688664
SGTC_1411 3909-8223 150 µM -0.11325996331511 0.446156162476753 no 1884 0.454912228793776 591 X1411
SGTC_2786 7743617 45.45 µM -0.113261441905904 0.446155542712638 no 1885 0.454911642692723 617 583674
SGTC_1255 0566-0045 221 µM -0.113649053575889 0.445993076471712 no 1886 0.454758000050338 621 2788469
SGTC_2317 5986382 200 µM -0.115915982155298 0.445043082773778 no 1887 0.45385956457683 595 877883
SGTC_2384 9036245 200 µM -0.116024656056124 0.444997549071112 no 1888 0.45381650052558 581 6462766
SGTC_2091 4-phenylthiadiazole 200 µM -0.116051547589923 0.444986281794192 no 1889 0.453805844339729 597 270010
SGTC_996 3970-0799 1.8 µM -0.117996684124272 0.444171407974757 no 1890 0.45303514260729 610 6615648 YGL040C HEM2
SGTC_334 1502-1024 68.5 µM -0.118262535788466 0.444060053292823 no 1891 0.452929820571781 599 3296216
SGTC_2092 5303694 80.6725 µM -0.120675995588669 0.443049354115454 no 1892 0.451973836383389 625 1963699
SGTC_1625 st003711 30.1 µM -0.120911855219377 0.442950601514054 no 1893 0.451880425980291 615 24207034 YER133W GLC7
SGTC_2160 5660466 132.927 µM -0.12218482779367 0.442417679083243 no 1894 0.451376321043265 661 2859134
SGTC_2861 9024595 19.48 µM -0.122567818419321 0.442257362669276 no 1895 0.451224669715232 592 16482810
SGTC_367 0335-0881 7.1 µM -0.122604555993425 0.442241985149457 no 1896 0.451210123252847 616 23828853
SGTC_16 erodoxin 22.806 µM -0.123678325504728 0.441792567994504 no 1897 0.450784986811197 611 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1232 0279-0259 161 µM -0.123849919195858 0.441720755833177 no 1898 0.450717053119455 603 1560000
SGTC_303 1348-1668 34.2 µM -0.12397839926154 0.441666988028717 no 1899 0.450666188994128 599 5380509
SGTC_212 3807-4682 38.772 µM -0.125470856279454 0.441042486597168 no 1900 0.450075398001089 592 3125501 YBL034C STU1
SGTC_293 4049-0273 38.5 µM -0.125958837479727 0.440838328212488 no 1901 0.449882253962063 602 1380311
SGTC_2785 7756463 72.73 µM -0.12600721270581 0.440818090157341 no 1902 0.449863107586534 598 2201551
SGTC_755 1995-0008 37.3 µM -0.126311679503802 0.440690718264376 no 1903 0.449742605700627 594 689533
SGTC_343 4130-2827 29.8 µM -0.127581569542724 0.44015953355424 no 1904 0.449240058649254 603 1118244
SGTC_2707 st078556 66.6 µM -0.128076913044254 0.439952364524157 no 1905 0.449044053140708 590 17250899
SGTC_2030 5175110 200 µM -0.128369894412213 0.439829837763027 no 1906 0.448928127395449 643 2831986
SGTC_1911 st060208 74.3 µM -0.129429612310852 0.43938670487693 no 1907 0.448508858753001 606 688783
SGTC_1217 1183-1422 255 µM -0.129735559621052 0.439258783691979 no 1908 0.448387823900913 602 2849664
SGTC_268 camptothecin 39.6153 µM -0.132359093179969 0.43816210650396 no 1909 0.447350134429213 616 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_574 1315-0397 40 µM -0.132428678514409 0.438133025194653 no 1910 0.447322616129453 598 6794277
SGTC_141 0443-0274 32.331 µM -0.133126044155059 0.437841598555792 no 1911 0.447046849104078 619 1627241
SGTC_91 0417-1751 58.384 µM -0.133608547845902 0.437639981688998 no 1912 0.446856062297328 599 6795624
SGTC_2988 9073640 71.4286 µM -0.133617213519522 0.43763636083663 no 1913 0.446852635915217 624 9102229
SGTC_922 1866-0035 480 µM -0.134666863872402 0.437197815186183 no 1914 0.446437636642027 638 3156169
SGTC_2361 9034121 116 µM -0.134766347452201 0.437156254776604 no 1915 0.446398306948744 622 6496917
SGTC_1934 st074720 32.6 µM -0.135632751073903 0.43679433406752 no 1916 0.446055806539395 602 17250992
SGTC_2976 9009005 19.48 µM -0.136606142645683 0.436387784650436 no 1917 0.445671060447571 599 2993148
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.137095100450138 0.436183590506648 no 1918 0.445477812588858 591 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.138624262667055 0.435545105596135 no 1919 0.444873534793017 623 521171
SGTC_892 0929-0076 29 µM -0.138772296879463 0.435483304426085 no 1920 0.444815043010683 593 5751038
SGTC_2570 licareol 100 µM -0.13878798402229 0.435476755466214 no 1921 0.444808844723756 647 443158
SGTC_336 4111-0029 111 µM -0.138797536235804 0.435472767682862 no 1922 0.444805070470082 631 3131175
SGTC_1164 k060-0068 93.7 µM -0.139380037377565 0.435229602079929 no 1923 0.444574923120727 599 5963676
SGTC_159 3970-0959 50 µM -0.139550786366311 0.435158327405403 no 1924 0.444507463396541 611 6615653
SGTC_3157 9099274 49.47 µM -0.139791345798815 0.435057915772498 no 1925 0.444412425602862 590 17217662
SGTC_131 0141-0277 33.849 µM -0.140542286878261 0.434744493300174 no 1926 0.444115771961339 631 1547771
SGTC_1657 st012939 43.4 µM -0.140583343321886 0.43472735863275 no 1927 0.444099553822326 609 24207257
SGTC_3269 9137823 49.47 µM -0.140745310775505 0.434659763656214 no 1928 0.44403557426275 601 17682936
SGTC_2464 5717415 7.67 µM -0.140789516536855 0.434641315297535 no 1929 0.444018112581065 604 5285744
SGTC_2423 st077119 87.2 µM -0.141793155696674 0.434222505656618 no 1930 0.443621695204309 603 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2188 6126565 140.678 µM -0.142722268027235 0.433834861182497 no 1931 0.443254764706691 630 874518
SGTC_454 lyso-paf C-16 6.67 µM -0.143593693026354 0.433471342847625 no 1932 0.44291066063905 629 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_317 4495-0002 170 µM -0.14410440637057 0.433258322920061 no 1933 0.442709012630765 620 15991618
SGTC_952 1185-0122 232 µM -0.144160061979416 0.433235109984457 no 1934 0.442687038689206 594 678600
SGTC_1887 st057648 70.8 µM -0.144983247959259 0.432891801122273 no 1935 0.442362049112375 601 688672
SGTC_1857 st056007 79.3 µM -0.145793788328176 0.432553815580833 no 1936 0.442042089851874 612 619834
SGTC_109 0132-0036 33.701 µM -0.146229359544264 0.432372208013089 no 1937 0.44187016455202 589 67274 A color developer.
SGTC_634 1611-4317 11.2 µM -0.146602609909143 0.432216595938711 no 1938 0.441722846767219 618 2843522
SGTC_3186 9110464 49.47 µM -0.146913729918037 0.432086894709095 no 1939 0.441600057304805 622 17018021
SGTC_98 0074-0023 107.663 µM -0.147459400617085 0.431859430525974 no 1940 0.441384711487042 658 3563821
SGTC_762 1165-0429 115 µM -0.148044461758697 0.431615571434881 no 1941 0.441153839706552 599 5967793
SGTC_2023 5144124 124 µM -0.149042900685555 0.431199472752083 no 1942 0.440759890572467 596 2830192
SGTC_457 grayanotoxin iii 135 µM -0.149526858028135 0.430997811331395 no 1943 0.440568958974645 621 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2794 7785382 27.27 µM -0.150096064418688 0.430760650291684 no 1944 0.440344412475237 626 2205081
SGTC_2749 bexarotene 57.39 µM -0.150606226465342 0.430548111416752 no 1945 0.440143174706796 613 82146 An retinoic acid receptor inhibitor.
SGTC_3175 9106517 49.47 µM -0.151369927905266 0.430229982979905 no 1946 0.439841955075523 632 41468073
SGTC_1489 4065-0444 182 µM -0.151393519315618 0.430220156432178 no 1947 0.439832650689249 605 2877968
SGTC_1371 2421-0008 32.7 µM -0.151820979675091 0.430042113541944 no 1948 0.439664067279948 633 2827552
SGTC_2608 thymoquinone 42.66 µM -0.152095030967313 0.429927975036726 no 1949 0.439555991663675 600 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1922 5578187 25 µM -0.152773963311222 0.429645234516564 no 1950 0.439288265470261 597 1350412
SGTC_2154 5570129 200 µM -0.153752330746592 0.429237858127339 no 1951 0.438902510671211 622 673366
SGTC_1258 0671-0043 57.1 µM -0.154473810053175 0.42893749405146 no 1952 0.438618079947198 653 4298767
SGTC_1964 st076914 61 µM -0.155063740773544 0.428691926453454 no 1953 0.438385533524498 620 24208661
SGTC_1266 0828-0227 32.9 µM -0.155580166100538 0.428476979243956 no 1954 0.438181979854567 623 3913820
SGTC_951 1171-0579 82.7 µM -0.15669432530989 0.428013314815427 no 1955 0.437742879790403 631 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2589 lobaric acid 100 µM -0.157165242302171 0.427817369560494 no 1956 0.437557310226271 622 73157 A novel microtubule depolymerizer.
SGTC_546 peri-Naphthalide 147 µM -0.157918411475348 0.427504018174357 no 1957 0.437260544924026 611 223824 A penicillin ester.
SGTC_1904 st060225 78 µM -0.158373304611827 0.42731478482832 no 1958 0.437081324058892 607 66595
SGTC_3085 9117376 49.47 µM -0.158515552327659 0.427255613896268 no 1959 0.437025283305625 614 16480349
SGTC_393 acivicin 6.25 µM -0.158611156352582 0.427215846308879 no 1960 0.436987619287261 634 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1936 st074407 74.3 µM -0.15973360017617 0.426749008387562 no 1961 0.436545465805683 606 809813
SGTC_2827 7993847 71.43 µM -0.15975115140594 0.426741709432402 no 1962 0.436538552646846 621 2985692
SGTC_2998 9066762 71.4286 µM -0.1605596550627 0.426405507694308 no 1963 0.43622011656639 623 4945196
SGTC_3304 9125678 46.087 µM -0.160847945480194 0.426285640217189 no 1964 0.436106580906249 621 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_152 4469-0003 551.229 µM -0.162439602841051 0.425623972265619 no 1965 0.435479843196857 625 697280
SGTC_2723 salbutamol 83.58 µM -0.162960924314677 0.425407299124344 no 1966 0.435274600605647 621 9884233 β2-adrenoceptor agonist
SGTC_2888 9058547 12.99 µM -0.163812465492207 0.42505342758917 no 1967 0.43493938910122 626 16476514
SGTC_1106 tegaserod maleate 11.7 µM -0.163951628613376 0.424995601864376 no 1968 0.434884611598136 619 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1636 st007707 68.9 µM -0.165164225093021 0.424491806409785 no 1969 0.434407361369331 645 403051
SGTC_2797 7859098 81.82 µM -0.165376075959159 0.4244038017136 no 1970 0.434323991503828 610 972681
SGTC_1707 st032323 6.317 µM -0.165443825452543 0.424375658778692 no 1971 0.434297330599826 624 3132057 YMR211W DML1
SGTC_833 3852-0053 558 µM -0.165753964407088 0.424246832918302 no 1972 0.434175287970621 635 3123681
SGTC_1124 fisetin 1.16336 µM -0.165824210598395 0.424217655101686 no 1973 0.43414764629704 652 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3239 9133757 49.47 µM -0.166564586675138 0.423910154003834 no 1974 0.433856330053563 637 17036923
SGTC_2269 7935389 174.42 µM -0.166734856904398 0.423839442053014 no 1975 0.433789338793797 600 97605
SGTC_2163 5671233 125 µM -0.166904549341378 0.423768972494732 no 1976 0.433722576753286 595 701023
SGTC_919 tnp00227 403.569 nM -0.167299179701358 0.423605100566348 no 1977 0.43356732477347 654 1269246 A methoxyflavone. YNL221C POP1
SGTC_1182 1222-0449 220 µM -0.167648656170549 0.423459990012171 no 1978 0.433429845394106 612 658318
SGTC_1382 3002-2117 298 µM -0.168991698129056 0.422902425307216 no 1979 0.432901585708732 630 1497314
SGTC_2919 7978188 46.38 µM -0.169661456058909 0.422624432513563 no 1980 0.432638194068165 599 2980291
SGTC_1851 st056236 18.9 µM -0.170637411365732 0.42221941705254 no 1981 0.432254439652084 619 5393171
SGTC_2321 7390090 138.78 µM -0.172629084718412 0.421393140429921 no 1982 0.431471494405677 641 649046
SGTC_41 0478-0632 82.643 µM -0.173000297551004 0.421239175170151 no 1983 0.431325596868764 632 3750424
SGTC_1874 staurosporine 7.6 µM -0.173549920831253 0.421011234022707 no 1984 0.4311095960018 621 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2417 cerulenin 830 nM -0.17359724776364 0.420991607715361 no 1985 0.431090997573063 647 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1028 k015-0029 4.8 µM -0.175644845256345 0.420142665110312 no 1986 0.43028648429377 614 4588309
SGTC_1803 st050068 52.4 µM -0.175865170326755 0.420051339463808 no 1987 0.430199934439141 628 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3349 9149703 23.001 µM -0.177162478515003 0.419513687344434 no 1988 0.429690383612246 634 4910494
SGTC_885 0865-0106 16.8 µM -0.177212486305286 0.419492965281654 no 1989 0.429670744117758 620 2793380
SGTC_2398 5228213 48.84 µM -0.178255039227519 0.419061006579468 no 1990 0.429261343371989 631 80771 YMR134W ERG29
SGTC_3167 9103034 49.47 µM -0.179250388022959 0.418648696873141 no 1991 0.428870550224895 617 5127859
SGTC_2671 danthron 100 µM -0.179661211878148 0.418478544701596 no 1992 0.428709273155408 621 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3341 9147222 25.867 µM -0.179815522244666 0.418414637444323 no 1993 0.428648698627884 655 1939759
SGTC_1262 0737-0114 49.6 µM -0.180966116436296 0.41793818970589 no 1994 0.428197086012896 636 765919
SGTC_3251 9135047 49.47 µM -0.181079894915499 0.417891081885531 no 1995 0.428152432624378 632 17682963
SGTC_1827 berberine 7.24 µM -0.183785848437812 0.416771081823742 no 1996 0.427090729171408 638 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_845 0330-0138 4.51 µM -0.185142260789461 0.416209913286412 no 1997 0.426558727614726 627 9039800
SGTC_955 1216-0110 33 µM -0.186116456126223 0.415806979071878 no 1998 0.426176718627967 618 3619719
SGTC_324 1315-0088 19.6 µM -0.186955708571007 0.415459929150433 no 1999 0.425847680007151 654 6787421
SGTC_418 lividomycin a 100 µM -0.187262725023062 0.415332987342837 no 2000 0.425727323543559 625 72394 An antibiotic.
SGTC_65 0798-0905 34.986 µM -0.187575478450142 0.415203682559793 no 2001 0.42560472518802 736 3602145
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.188962253564707 0.41463044505997 no 2002 0.425061200529334 611 688803
SGTC_1741 st038134 10.228 µM -0.190001236509734 0.414201089993289 no 2003 0.424654080793364 644 1272587
SGTC_2738 aclarubicin 5.55 µM -0.190030851314 0.414188853307849 no 2004 0.42464247757159 637 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3119 9125183 49.47 µM -0.191390007804626 0.413627346631304 no 2005 0.424110023992971 629 22695334
SGTC_877 0771-0151 33.1 µM -0.192775518504994 0.413055134013732 no 2006 0.42356738862354 655 6166523
SGTC_2883 9059145 45.46 µM -0.194007568963991 0.412546455182738 no 2007 0.42308497766515 622 16476510
SGTC_1176 0848-0131 83.3 µM -0.194609238123424 0.412298096296353 no 2008 0.422849435180374 651 6769040
SGTC_86 0417-1630 471.922 µM -0.195087432912666 0.412100730589128 no 2009 0.422662250321431 624 3634867
SGTC_2733 amorolfine 100 µM -0.196291409853663 0.411603910800973 no 2010 0.422191042275509 636 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1703 st026983 48.3 µM -0.196532644117834 0.411504382755489 no 2011 0.42209664226975 638 1104023
SGTC_219 mitoxanthrone 164.414 µM -0.196726982283955 0.411424207168013 no 2012 0.422020596941299 636 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_482 fipronil 114 µM -0.197299026090946 0.411188227922012 no 2013 0.421796770717117 610 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_681 1642-0006 26.6 µM -0.197600152940595 0.411064020116957 no 2014 0.421678957566944 647 4446530
SGTC_1998 st075797 76.8 µM -0.198447428287613 0.410714586662236 no 2015 0.421347506411707 654 24208315
SGTC_2430 5571206 200 µM -0.1995623117776 0.410254894200908 no 2016 0.420911452828502 647 1731771
SGTC_902 1120-0002 2.07 µM -0.200165039810907 0.410006426678952 no 2017 0.420675754014035 649 3280475
SGTC_55 0767-0285 6.563 µM -0.200358786757153 0.409926564454395 no 2018 0.420599994657519 648 3116166
SGTC_2389 9091542 195.52 µM -0.201621521091551 0.409406158772887 no 2019 0.420106309669661 637 3626624 YOL127W RPL25
SGTC_178 4092-0806 87.505 µM -0.202205715997004 0.409165450791475 no 2020 0.419877952355902 617 2169044
SGTC_319 1348-1596 45.5 µM -0.203546353221313 0.408613192704776 no 2021 0.41935400963205 670 5380505
SGTC_2202 7226349 200 µM -0.20499679780123 0.408015905241184 no 2022 0.418787313442189 628 844334
SGTC_2018 5133068 143 µM -0.205033506806112 0.408000791381846 no 2023 0.41877297322544 647 785362
SGTC_1578 josamycin 24.2 µM -0.205860396039659 0.407660380231279 no 2024 0.418449981093707 669 5282165 A P450 substrate.
SGTC_1119 parthenolide 318.541 nM -0.207280311139885 0.407075996819617 no 2025 0.417895474836513 690 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1428 4049-0204 61.7 µM -0.207433216705661 0.407013078976615 no 2026 0.417835771759174 652 X1428
SGTC_2880 9042983 58.44 µM -0.208898967248971 0.40641007142225 no 2027 0.417263555195959 670 6464714
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.208904796737384 0.406407673621605 no 2028 0.417261279762161 669 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_401 neomycin 50 µM -0.209125537437594 0.406316880554357 no 2029 0.417175119721458 643 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3222 9128301 49.47 µM -0.21085385673977 0.405606178380307 no 2030 0.416500655772939 645 4911358
SGTC_1409 3909-8004 61.9 µM -0.215993966155658 0.403494360825396 no 2031 0.414496225435389 631 2119279
SGTC_3338 9144300 39.5675 µM -0.216126029208467 0.403440139403243 no 2032 0.414444755390484 659 4901274
SGTC_2690 usnic acid 100 µM -0.217294863589968 0.402960329486131 no 2033 0.413989279866971 682 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2005 4024620 188 µM -0.217870539113368 0.402724066656541 no 2034 0.413764991065836 654 236743
SGTC_2896 9052656 71.43 µM -0.218115810648479 0.402623415620334 no 2035 0.413669439423798 660 6469436
SGTC_2597 laccaic acid a 100 µM -0.218354603398366 0.402525429456095 no 2036 0.413576416664933 664 5491415 A textile dye.
SGTC_1480 1070-0044 41.2 µM -0.218385283333144 0.402512840702216 no 2037 0.413564465513819 631 3124987
SGTC_2740 felodipine 17.08 µM -0.219020253341265 0.402252319149822 no 2038 0.413317135442214 642 3333 L-type calcium channel blocker
SGTC_479 n-linoleoylglycine 10 µM -0.219770822892486 0.401944424310805 no 2039 0.413024822027902 659 6433346 An anti-infammatory.
SGTC_607 4491-0986 66.8 µM -0.221447095503416 0.40125701219831 no 2040 0.412372162809389 648 698981 YDR232W HEM1
SGTC_578 3460-0051 92 µM -0.221944593691678 0.401053054987517 no 2041 0.412178507688793 672 2876744
SGTC_596 1155-0152 116 µM -0.222396831512957 0.400867676370166 no 2042 0.41200248907658 634 280313
SGTC_2075 5212009 200 µM -0.22269728962154 0.400744526721183 no 2043 0.411885555482152 641 780898
SGTC_2458 5808907 16.39 µM -0.222797697945462 0.400703374264427 no 2044 0.411846479877325 654 2731747
SGTC_2366 9070441 60.58 µM -0.223028612807233 0.400608737748568 no 2045 0.411756618753848 663 6837235
SGTC_383 2324-0395 7.37 µM -0.223904649143006 0.400249762297702 no 2046 0.411415749038412 666 3146421
SGTC_2074 5212007 75.395 µM -0.225358295407712 0.399654284317424 no 2047 0.410850276304629 622 758611
SGTC_2941 9056145 11.23 µM -0.226225679897293 0.399299076219083 no 2048 0.410512949308125 658 2119517
SGTC_134 0269-0018 6.916 µM -0.227642704905244 0.398718960800038 no 2049 0.409962008866629 630 4378915
SGTC_2914 7968218 45.32 µM -0.22799542159514 0.39857459694595 no 2050 0.409824899917954 676 2977111
SGTC_633 0437-0093 97.7 µM -0.228885363322511 0.398210413308045 no 2051 0.409479008496569 650 2831118
SGTC_470 aa-861 153 µM -0.229380978332552 0.398007635207348 no 2052 0.409286409577312 640 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.229633608992383 0.397904283386074 no 2053 0.409188244232894 642 16623 A steroid.
SGTC_3191 9110352 49.47 µM -0.230082833310259 0.397720522318288 no 2054 0.409013702055748 637 17122424
SGTC_2948 9070189 9.45 µM -0.230552837531497 0.397528285250633 no 2055 0.408831105340093 653 6473636 YDL196W YDL196W
SGTC_2870 9038528 12.99 µM -0.234023573420527 0.39610948809772 no 2056 0.407483338904652 669 6463316
SGTC_1185 1319-0113 81.3 µM -0.234672395431727 0.395844409067085 no 2057 0.407231507360207 673 4672763
SGTC_2216 7189485 200 µM -0.234715954517072 0.395826614538869 no 2058 0.407214601858917 658 731273
SGTC_1434 4073-0095 163 µM -0.235008581639465 0.395707077677689 no 2059 0.407101036275254 650 24133745
SGTC_2416 tofa 880 nM -0.236094674411925 0.395263499523583 no 2060 0.406679603170053 650 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3241 9133421 49.47 µM -0.23754109542515 0.394672968137925 no 2061 0.40611852089833 655 17018221
SGTC_51 1013-0126 23.419 µM -0.239997666060026 0.393670577239961 no 2062 0.40516603297637 683 1627850
SGTC_1767 st044992 70.3 µM -0.240796079513404 0.393344940081318 no 2063 0.404856584164458 660 9600693
SGTC_1051 3253-3903 78 µM -0.243052225271561 0.392425163001878 no 2064 0.403982470132052 627 5509239
SGTC_3230 9131665 49.47 µM -0.243191527005686 0.392368392624613 no 2065 0.403928515169473 653 15943720
SGTC_1385 3091-4834 14.1 µM -0.243225439619458 0.392354572383225 no 2066 0.403915380262819 651 4072814
SGTC_1773 st048542 73.5835 µM -0.243730795393346 0.392148643314427 no 2067 0.403719660599949 654 3237138
SGTC_2773 thioridazine 9.09 µM -0.243842133497314 0.392103277846275 no 2068 0.403676543610784 641 5452 An antipsychotic.
SGTC_126 0417-1624 672.48 µM -0.245390731828635 0.391472443240789 no 2069 0.403076952301641 681 41912 YDL195W SEC31
SGTC_3329 9141233 27.5565 µM -0.245531179114825 0.391415244940008 no 2070 0.403022584714221 690 4909101 YNL103W MET4
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.245898733672179 0.3912655664691 no 2071 0.40288031206172 703 6728940
SGTC_908 3448-7491 47.7 µM -0.247373110406539 0.39066532116765 no 2072 0.402309741201273 642 1203031
SGTC_1766 st045414 44.774 µM -0.247550661211294 0.390593054582353 no 2073 0.402241044611058 649 253960
SGTC_327 1273-0057 3.96 µM -0.247747637487267 0.390512885879444 no 2074 0.402164835600108 658 3108138
SGTC_515 4092-1064 102 µM -0.248836272136195 0.390069899157137 no 2075 0.401743716139675 712 717353
SGTC_598 3937-0236 20.2 µM -0.249465781250977 0.389813804679185 no 2076 0.401500253459396 644 1379313
SGTC_1853 st056710 91.2 µM -0.250108283253463 0.389552473802241 no 2077 0.401251805202178 682 269167
SGTC_2933 9026794 32.47 µM -0.250178260874766 0.38952401416009 no 2078 0.401224748056564 683 17586027
SGTC_2727 riluzole 51.77 µM -0.251615461329794 0.388939641245707 no 2079 0.400669153318261 660 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3286 9117135 37.221 µM -0.252847075760093 0.388439060426608 no 2080 0.400193194071799 647 3438150
SGTC_1020 4335-0961 93.3 µM -0.253436119667624 0.388199713200818 no 2081 0.399965609515407 694 669075
SGTC_2647 atorvastatin 60.16 µM -0.253517482630516 0.388166656183064 no 2082 0.399934176575323 674 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_247 mechlorethamine 29.705 µM -0.253750091548902 0.388072153805403 no 2083 0.399844316387194 653 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3039 9090270 49.47 µM -0.253827742268279 0.388040608005244 no 2084 0.399814319972231 635 17173750
SGTC_768 0384-0033 77.3 µM -0.253977846027231 0.387979630069915 no 2085 0.399756336678335 665 3965305 YMR134W ERG29
SGTC_1179 1021-1431 9.29 µM -0.254126922962419 0.387919072003695 no 2086 0.399698752222049 698 2840958
SGTC_2711 st079103 59.1 µM -0.254953096065305 0.387583513227849 no 2087 0.399379663097457 667 54693780
SGTC_586 0957-0265 8.15 µM -0.255342056001666 0.387425562166317 no 2088 0.39922946010458 669 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3084 9116877 49.47 µM -0.256177729789843 0.387086270056148 no 2089 0.398906802017186 659 27241325
SGTC_595 3909-8003 73.7 µM -0.256773865997168 0.386844285351009 no 2090 0.398676672858171 690 699517
SGTC_926 2268-1401 59.4 µM -0.257376275515276 0.38659979884956 no 2091 0.398444157766497 649 2931578
SGTC_1693 xanthone 101.9 µM -0.258062747794835 0.386321250537608 no 2092 0.398179240488133 674 7020 An insecticide.
SGTC_1680 diphenhydramine 100 µM -0.25810595659169 0.386303719759383 no 2093 0.398162567302042 660 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2078 5212016 200 µM -0.258184434685212 0.386271880029881 no 2094 0.398132285058532 676 1899708
SGTC_1423 4048-0112 5.59 µM -0.261410401733974 0.384963722336161 no 2095 0.396888018211507 661 X1423
SGTC_3116 9124943 49.47 µM -0.26150618049403 0.384924903141641 no 2096 0.396851091979369 629 41905195 YPL160W CDC60
SGTC_637 1181-0519 7.26 µM -0.261812433597609 0.384800786299266 no 2097 0.396733026360429 679 6252091 YGR060W ERG25
SGTC_1765 st044815 90.4 µM -0.261865860480397 0.38477913490811 no 2098 0.396712430386023 652 645695
SGTC_3155 9099265 49.47 µM -0.262663359762417 0.384455988879291 no 2099 0.396405030022515 690 25236499
SGTC_1093 fluphenazine 7.97 µM -0.263648438482723 0.384056946660697 no 2100 0.39602541506375 683 6602611 An atypical antipsychotic.
SGTC_2889 9059656 51.95 µM -0.263655253377424 0.384054186465485 no 2101 0.396022789184131 671 3949838
SGTC_3293 9120939 62.045 µM -0.264253581644296 0.383811872158106 no 2102 0.395792262866947 702 934087
SGTC_1321 1326-2144 215 µM -0.264757311344332 0.383607904117638 no 2103 0.395598212120186 692 3513030
SGTC_2470 5664817 21.68 µM -0.265464119951323 0.383321760629524 no 2104 0.395325973348189 655 2859561
SGTC_1045 1348-1485 165 µM -0.266598644603086 0.382862594239501 no 2105 0.394889099663633 669 6810614
SGTC_1002 4049-0206 172 µM -0.2674138081774 0.382532781669386 no 2106 0.394575284526779 650 4662749
SGTC_1660 st012960 28.1 µM -0.26756671954241 0.382470923702111 no 2107 0.394516425548444 696 24207266
SGTC_2326 6164455 177.58 µM -0.267926026394636 0.382325583383815 no 2108 0.394378129845635 672 2888790
SGTC_423 5-fluorouracil 457 µM -0.270347295655654 0.381346608458822 no 2109 0.393446541396723 657 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_808 0711-0032 135 µM -0.270828344302711 0.381152199557596 no 2110 0.393261529343405 689 4252555
SGTC_928 2764-0428 58.7 µM -0.272484540236997 0.380483101417201 no 2111 0.392624738410833 680 662578
SGTC_63 0099-0242 26.702 µM -0.272527908329659 0.380465585632339 no 2112 0.392608067661876 683 3898502 YLR359W ADE13
SGTC_2146 5545642 200 µM -0.273374209511323 0.380123825149961 no 2113 0.392282787905199 671 825326
SGTC_2884 9058502 51.95 µM -0.273821160549756 0.379943371354375 no 2114 0.392111030565087 684 6471554
SGTC_532 1548-0774 215 µM -0.274778108793065 0.379557097183929 no 2115 0.391743358801092 706 5932993
SGTC_2359 9039622 200 µM -0.276271496260187 0.378954528426513 no 2116 0.391169773473808 660 6463596
SGTC_558 k064-0027 21.3 µM -0.276680326190651 0.378789620339157 no 2117 0.391012789888572 662 5088526
SGTC_3196 9111891 49.47 µM -0.277636236156255 0.378404124930445 no 2118 0.390645806418775 671 18891510
SGTC_1014 4130-3005 69.3 µM -0.277784746638376 0.378344245087736 no 2119 0.390588800480091 677 743608
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.27812413864217 0.378207412249666 no 2120 0.390458533254909 660 140250 A respiratory chain inhibitor.
SGTC_497 capsazepine 133 µM -0.279216465506918 0.377767122067359 no 2121 0.390039354148359 648 2733484 A calcium channel blocker.
SGTC_1712 st032288 53.4 µM -0.281601827416405 0.376806193736013 no 2122 0.389124419409138 675 2883011
SGTC_1814 st052110 31.539 µM -0.28267431296078 0.376374397728288 no 2123 0.388713254386176 695 674163
SGTC_2376 9072922 81.32 µM -0.283725663437453 0.375951261075266 no 2124 0.388310313005986 712 17087968
SGTC_1207 2099-0101 141 µM -0.285595302728404 0.375199156641432 no 2125 0.387594050780706 709 5837381
SGTC_3022 9087993 49.47 µM -0.2880783660123 0.374201022111591 no 2126 0.386643376199286 657 17173644
SGTC_2662 daunorubicin 22.37 µM -0.289031566940793 0.373818080651625 no 2127 0.386278610522121 649 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_807 1315-0151 48 µM -0.289883896564331 0.373475768933476 no 2128 0.385952530804542 703 4011080
SGTC_2512 diallyl trisulfide 49.23 µM -0.291498145249125 0.372827729810903 no 2129 0.385335181097585 687 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1170 0310-0127 64.8 µM -0.29188020275969 0.372674405641173 no 2130 0.3851891103141 705 774975
SGTC_2902 5787006 60.46 µM -0.293778575290113 0.371912866000173 no 2131 0.384463553746975 684 591003
SGTC_1268 0828-0275 2.46 µM -0.295272628139233 0.371313872813612 no 2132 0.383892812210722 692 745337
SGTC_168 3970-0862 530.542 µM -0.296347355068393 0.3708831876454 no 2133 0.383482412521655 664 3135186
SGTC_3110 9122132 49.47 µM -0.296350792455561 0.370881810408894 no 2134 0.383481100116148 654 918317
SGTC_432 NS 1619 61.3 µM -0.296407006185204 0.370859287838701 no 2135 0.383459637722575 664 4552 A K+/calcium channel activator.
SGTC_2755 lomerizine 42.69 µM -0.2973710610434 0.370473098928284 no 2136 0.38309161742902 674 3949 A calcium channel blocker.
SGTC_684 1140-0066 328 µM -0.298016187721701 0.370214741709506 no 2137 0.382845404333732 693 6813534
SGTC_15 0266-0086 27.098 µM -0.298526238288254 0.370010520553626 no 2138 0.382650776640217 679 1712902 YIL048W NEO1
SGTC_2679 rapamycin 1 nM -0.299845555816057 0.369482443932427 no 2139 0.382147482305346 692 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2904 7225135 42.03 µM -0.303575350136616 0.367990872234537 no 2140 0.380725716773792 697 4446116
SGTC_495 decylubiquinone 155 µM -0.3041535878891 0.367759808222929 no 2141 0.3805054411127 706 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2007 4011539 71.82 µM -0.304785575107245 0.367507320638184 no 2142 0.380264734273506 660 45595301
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.307152037605427 0.366562395778371 no 2143 0.379363825229616 708 688751
SGTC_172 1112-0046 2.638 µM -0.307556789279322 0.366400859837521 no 2144 0.37920980224823 714 2802135 YIL048W NEO1
SGTC_2100 5377183 190 µM -0.308318515182859 0.366096920082436 no 2145 0.378919989380672 682 2844202
SGTC_1629 st005085 44.9 µM -0.308467555292617 0.366037460722833 no 2146 0.378863292239081 701 24207091
SGTC_1407 3909-7909 12.3 µM -0.308637829073854 0.365969534154589 no 2147 0.378798520673567 673 4411780
SGTC_2866 9034245 58.44 µM -0.309194052551034 0.365747671662607 no 2148 0.37858695888999 680 6462273
SGTC_2832 7992762 51.95 µM -0.310476408927442 0.365236345588843 no 2149 0.37809934833055 655 2985177
SGTC_1895 st058434 18.3 µM -0.310856649889262 0.365084774509605 no 2150 0.377954800598746 724 5393175
SGTC_685 1278-0033 54.9 µM -0.310858520304995 0.365084028979377 no 2151 0.377954089606695 665 3590572
SGTC_695 3505-6186 243 µM -0.311067681511897 0.365000662495188 no 2152 0.37787458478106 698 1819379
SGTC_1251 0490-5699 265 µM -0.311595811496308 0.364790191349665 no 2153 0.377673858907494 693 3883818
SGTC_1205 4161-2785 76 µM -0.312242986908698 0.364532333598814 no 2154 0.377427932589795 722 3498106
SGTC_1730 st033808 45.1 µM -0.312752558762839 0.364329345127685 no 2155 0.377234330513495 680 1045166
SGTC_1159 4092-0538 61.2 µM -0.312759986882826 0.364326386409676 no 2156 0.377231508569463 672 717301
SGTC_3017 9080681 49.47 µM -0.313196467779988 0.364152544520732 no 2157 0.37706570091891 693 16451914
SGTC_224 benfluorex 43.875 µM -0.313510185872501 0.364027613939835 no 2158 0.376946541637485 704 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2408 sulbentine 18.36 µM -0.314628252189334 0.363582488889501 no 2159 0.376521962823331 657 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_364 0083-0097 67.7 µM -0.314679833155647 0.363561957890539 no 2160 0.376502378868147 699 5207356
SGTC_2845 9003024 42.97 µM -0.31470085587092 0.363553590239078 no 2161 0.376494397179547 673 2990173
SGTC_1789 tunicamycin 25 nM -0.315031839478333 0.363421857729417 no 2162 0.376368739685562 705 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_900 1112-0045 141 µM -0.315142301038798 0.363377897276761 no 2163 0.376326806013777 684 56211 YIL048W NEO1
SGTC_2059 5238311 157 µM -0.31519515688525 0.363356862840653 no 2164 0.376306741272035 665 703021
SGTC_2391 6285546 200 µM -0.316704177859487 0.362756509060336 no 2165 0.375734039196608 669 846083
SGTC_2365 9042475 200 µM -0.317976689752828 0.362250510813062 no 2166 0.375251309421398 681 6464479
SGTC_220 paclitaxel 373.376 µM -0.318143249849902 0.362184298086877 no 2167 0.375188138974385 696 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_137 0438-0332 85.389 µM -0.318815181119854 0.36191722677242 no 2168 0.37493333283891 714 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_986 1493-0483 84 µM -0.318860431992989 0.361899243403955 no 2169 0.374916175008398 711 40079
SGTC_1449 4112-4002 201 µM -0.31918775786688 0.361769168327098 no 2170 0.374792069819059 669 2059539
SGTC_3073 9114972 49.47 µM -0.319924213252428 0.36147656886684 no 2171 0.374512891115785 685 41905075
SGTC_741 4582-0002 126 µM -0.320623774106205 0.361198702896411 no 2172 0.374247759459334 650 2912688
SGTC_1702 st027038 51 µM -0.321417424352745 0.360883553219557 no 2173 0.373947040181033 697 5521182
SGTC_2282 7944268 200 µM -0.3217171301741 0.360764567926334 no 2174 0.373833499623905 729 2970414
SGTC_958 1222-0007 33 µM -0.322633459939046 0.360400862276795 no 2175 0.37348642518428 717 7312461
SGTC_1294 1000-1494 117 µM -0.322725430562424 0.360364364662536 no 2176 0.373451595512208 671 712797 YDL207W GLE1
SGTC_2853 9015042 58.44 µM -0.322964758579081 0.360269395717224 no 2177 0.373360965805064 669 6457456
SGTC_117 lucigenin 22.078 µM -0.323559682866765 0.360033358203283 no 2178 0.373135707814114 719 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_199 4063-0024 41.6 µM -0.323930023266089 0.359886451777967 no 2179 0.372995506593947 700 306215
SGTC_2231 micatex 6.853 µM -0.324364941839389 0.359713954942411 no 2180 0.37283087923482 685 20737 An antifungal of unknown mechanism.
SGTC_355 1311-2252 105 µM -0.325473281569697 0.359274495953909 no 2181 0.372411450494835 680 5338538
SGTC_2103 5378138 10 µM -0.325540156336031 0.359247985918847 no 2182 0.372386147927514 704 244142
SGTC_2526 patulin 37.61 µM -0.326494732961986 0.358869653140298 no 2183 0.372025036828556 692 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1690 st023502 41.2 µM -0.328272397504369 0.358165470364791 no 2184 0.371352856213515 698 24207482
SGTC_3236 9132701 49.47 µM -0.329955970636896 0.357499004342706 no 2185 0.370716615503355 714 24282524
SGTC_170 4197-0004 226 µM -0.332314214082594 0.356566191266542 no 2186 0.36982600396011 679 218692
SGTC_1073 triclabendazole 3.09 µM -0.332861047399765 0.35635001129852 no 2187 0.36961958699535 689 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1331 1472-0049 76.2 µM -0.332877439547156 0.356343531692483 no 2188 0.369613399917479 685 24051409
SGTC_687 k029-0044 34.9 µM -0.333155054793852 0.356233800239464 no 2189 0.369508621511181 712 5829338
SGTC_617 3770-0098 35 µM -0.334290350195934 0.355785182230897 no 2190 0.369080235724563 715 5962639
SGTC_2307 7538926 6.34 µM -0.336825293958551 0.354784207108881 no 2191 0.368124302143631 682 96582
SGTC_414 piperonyl butoxide 100 µM -0.336978256362327 0.354723838709745 no 2192 0.3680666456876 700 5794 A potent inhibitor of cytochrome P450.
SGTC_3275 9138069 49.47 µM -0.337835387385352 0.354385629475869 no 2193 0.36774362041919 696 17617007
SGTC_1198 1612-1005 86.7 µM -0.338191349210158 0.35424520675234 no 2194 0.367609497265541 689 6998509
SGTC_1495 4469-0029 237 µM -0.340169846466531 0.353465074640135 no 2195 0.366864312304376 704 793680
SGTC_3067 9117431 49.47 µM -0.340257320440577 0.35343059735864 no 2196 0.366831377494974 704 17150885
SGTC_1925 st057770 10.1 µM -0.342316460828532 0.35261934886619 no 2197 0.366056374551685 705 5989122
SGTC_849 0386-0493 241 µM -0.342483909528922 0.352553407774345 no 2198 0.365993375507136 696 726119
SGTC_1022 4477-0945 21.3 µM -0.346826465136647 0.350844867254434 no 2199 0.364360846746055 689 4648966
SGTC_1591 genipin 88.4 µM -0.347882800922353 0.350429715268108 no 2200 0.363964101174326 703 442424 A DNA cross-linking agent.
SGTC_853 0419-0306 21 µM -0.348107714474825 0.350341344728857 no 2201 0.363879645466231 692 762713
SGTC_1431 4049-0260 9.09 µM -0.348148220655663 0.35032543035013 no 2202 0.36386443597735 708 3854841
SGTC_3219 9131112 49.47 µM -0.349235100002736 0.349898507066155 no 2203 0.363456408560105 703 17612988 YMR079W SEC14
SGTC_1049 3226-0134 66 µM -0.350827261074293 0.349273453057043 no 2204 0.362858972062902 700 5702385
SGTC_2984 9022109 38.96 µM -0.351580072427455 0.348978054920519 no 2205 0.36257660606122 718 6459207
SGTC_110 0850-0284 111.64 µM -0.35337057892582 0.348275840045564 no 2206 0.361905319748853 684 3906265
SGTC_2412 st077135 33.4 µM -0.354833150110023 0.34770262297583 no 2207 0.361357296026764 744 13258915
SGTC_1453 4237-0541 195 µM -0.35680761543936 0.346929334343018 no 2208 0.360617917374869 698 739892
SGTC_1769 st044406 64.4 µM -0.357338867623918 0.346721380942511 no 2209 0.360419067997803 723 670903
SGTC_1066 ketoconazole 628 nM -0.357811539995502 0.346536396842239 no 2210 0.36024217696069 729 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1512 0259-0544 12.2 µM -0.357812861463056 0.34653587972665 no 2211 0.360241682461821 678 18476
SGTC_3174 9107204 49.47 µM -0.359314814491012 0.345948321805439 no 2212 0.359679796490799 721 3938802
SGTC_2121 5257820 149.641 µM -0.36018945942606 0.345606334972614 no 2213 0.359352728309551 705 791256
SGTC_1719 st032227 49.2 µM -0.361409225552135 0.345129615863746 no 2214 0.358896776214395 681 3125804
SGTC_1071 trifluoperazine 6.31 µM -0.361601823232847 0.345054365679836 no 2215 0.358824801001048 729 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2820 7989630 71.43 µM -0.362171228326172 0.344831928242146 no 2216 0.358612039325283 678 2984098
SGTC_2222 6885208 172.143 µM -0.363071808599968 0.344480227103277 no 2217 0.358275621619834 683 609514
SGTC_2511 berberine 10.47 µM -0.363740887467394 0.344219020577166 no 2218 0.35802575398789 699 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_643 k048-0106 28.4 µM -0.365407325151547 0.34356877114857 no 2219 0.35740368703343 698 6763920
SGTC_1809 st050081 57.6 µM -0.369352546971449 0.342031179722131 no 2220 0.355932481614101 730 5036894
SGTC_2646 retinol 96.75 µM -0.37002653199609 0.341768765027674 no 2221 0.355681360797419 719 445354 A vitamin A analog and teratogen.
SGTC_3005 9076496 71.4286 µM -0.370074863646406 0.341749950134061 no 2222 0.355663355260102 718 21368410
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.370081234423015 0.341747470101492 no 2223 0.355660981906529 711 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_541 4513-1321 94 µM -0.372630675175453 0.34075556642026 no 2224 0.354711669526452 688 747515
SGTC_1397 3532-0190 20.1 µM -0.373349831077172 0.340475965095021 no 2225 0.3544440466668 686 5322280
SGTC_3111 9122088 49.47 µM -0.373705814345192 0.340337594436417 no 2226 0.354311599519852 714 16876704
SGTC_554 4483-2211 187 µM -0.374357174205791 0.34008446658237 no 2227 0.35406930017039 700 747107
SGTC_1154 4088-0362 150 µM -0.375069838277403 0.339807597581078 no 2228 0.35380426394816 716 6618304
SGTC_122 0236-0016 402.397 µM -0.375833504862023 0.339511010066006 no 2229 0.353520338767967 716 6808838
SGTC_1088 bifonazole 369 nM -0.380009436283858 0.337890952338602 no 2230 0.351969205268756 719 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2943 9068529 45.32 µM -0.380152282752337 0.337835587745788 no 2231 0.351916188877078 704 3270634
SGTC_1090 efavirenz 20.7 µM -0.380495166825465 0.337702706675974 no 2232 0.351788941784686 695 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1225 1216-0074 20.6 µM -0.381027352274852 0.33749650394347 no 2233 0.351591476280647 708 4241466
SGTC_136 0097-0015 404.482 µM -0.381167020478659 0.337442395614257 no 2234 0.351539659524726 708 4861337
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.38198175675441 0.337126828743711 no 2235 0.351237448234582 714 5024745
SGTC_2217 6934799 96.0675 µM -0.383305797644774 0.336614240461064 no 2236 0.350746520520901 719 675606
SGTC_273 hydroxyurea 18.1 mM -0.383389872330596 0.336581702080461 no 2237 0.350715355722359 711 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1989 st071868 50.2 µM -0.383779093783424 0.336431082486606 no 2238 0.350571092234741 729 16414057
SGTC_3091 9116372 49.47 µM -0.384198474916324 0.336268821176142 no 2239 0.350415674291084 715 17169793
SGTC_1603 st002045 67.8 µM -0.387043234732263 0.335168971290328 no 2240 0.349362100391327 725 5887985
SGTC_2868 9035608 32.47 µM -0.387863273534911 0.334852187036847 no 2241 0.349058609047068 696 6462614
SGTC_70 0141-0289 43.283 µM -0.387928387524623 0.334827038275102 no 2242 0.349034514891565 682 352408
SGTC_2627 acetyl isogambogic acid 100 µM -0.388106476509575 0.33475825933699 no 2243 0.348968619662471 727 6857789 A caspase activator and apoptosis inducer.
SGTC_1378 2093-0007 380 nM -0.389567276878933 0.334194299658474 no 2244 0.348428276677291 746 3618014
SGTC_1050 3232-1156 69.3 µM -0.389575467585985 0.334191138590348 no 2245 0.348425247840147 731 700529
SGTC_2009 4012297 12.05 µM -0.389659878497344 0.334158562278215 no 2246 0.348394034137815 729 45595307
SGTC_2765 myclobutanil 7.74 µM -0.389764829788844 0.334118060654536 no 2247 0.348355226388202 761 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2829 7992743 58.44 µM -0.390665522091353 0.333770555060519 no 2248 0.348022243470988 737 16462845
SGTC_1997 st073024 93.8 µM -0.391050313574446 0.33362213803672 no 2249 0.347880023053379 719 686268
SGTC_3273 9137859 49.47 µM -0.391192857045081 0.333567164534719 no 2250 0.347827343867161 723 2377234
SGTC_2967 9089538 49.85 µM -0.391724864103903 0.333362021559269 no 2251 0.347630758220983 716 728216
SGTC_1626 st003712 1.76 µM -0.391786806830788 0.333338139558772 no 2252 0.347607871992633 747 24207035
SGTC_2436 5633522 8.09 µM -0.392964705451069 0.332884129755769 no 2253 0.347172774837837 731 5724242
SGTC_528 3492-0019 172 µM -0.393707131136274 0.332598094626008 no 2254 0.346898637927742 706 2869262
SGTC_2110 5483698 200 µM -0.393721422091001 0.332592589690034 no 2255 0.346893361850888 699 2848765 YHR062C RPP1
SGTC_2783 7738165 71.43 µM -0.395421155162922 0.331938103125585 no 2256 0.346266049480191 690 17201110
SGTC_2021 4019055 173 µM -0.396364574347234 0.331575058179062 no 2257 0.345918048059826 734 44827708 YER133W GLC7
SGTC_2925 9010536 32.5 µM -0.398707174753488 0.330674267269221 no 2258 0.345054490318271 718 2994177
SGTC_2333 9017922 200 µM -0.398798340083759 0.330639231598168 no 2259 0.345020900121555 703 3163164
SGTC_3272 9137413 49.47 µM -0.39888431438386 0.33060619224708 no 2260 0.344989223697613 750 17614870
SGTC_2818 7996756 12.99 µM -0.400153165322144 0.33011873488743 no 2261 0.344521853903081 709 2241621
SGTC_565 1418-0001 44.5 µM -0.402989481204118 0.329030144186647 no 2262 0.343477981349169 747 2862145
SGTC_548 1436-0017 110 µM -0.404471411261758 0.328461948253892 no 2263 0.34293304834239 728 9677137
SGTC_910 3454-3003 490 µM -0.404900730857209 0.328297414192339 no 2264 0.342775240568463 746 820824
SGTC_1709 st033179 39.1045 µM -0.406994494184293 0.327495470137433 no 2265 0.342006016008135 707 573381
SGTC_1031 k035-0009 16 µM -0.407527384585873 0.327291491609238 no 2266 0.341810342695174 744 5180959
SGTC_2789 5281112 71.43 µM -0.407608626740676 0.327260398457518 no 2267 0.341780514923729 729 765948
SGTC_2558 carylophyllene oxide 100 µM -0.408505215064823 0.326917334116757 no 2268 0.341451401309616 748 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2580 diallyl disulphide 81.36 µM -0.409274060340419 0.326623264942022 no 2269 0.341169274732417 680 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3046 9092212 49.47 µM -0.409811525241706 0.32641775844478 no 2270 0.34097210552812 695 25236637
SGTC_527 4476-4215 268 µM -0.410493620558312 0.326157026533107 no 2271 0.340721941130396 695 4418754
SGTC_2843 9000894 45.46 µM -0.410645061442665 0.326099149558442 no 2272 0.340666408364634 693 2242070
SGTC_1336 1486-0901 104 µM -0.411097242132055 0.325926362170117 no 2273 0.340500616070746 698 5006114
SGTC_2212 7123476 200 µM -0.411980720180125 0.325588875215989 no 2274 0.340176777317037 715 1085715
SGTC_3242 9133940 49.47 µM -0.414259158612986 0.324719176118894 no 2275 0.33934216040243 748 17248444
SGTC_3115 9123671 49.47 µM -0.414263716205751 0.324717437402684 no 2276 0.339340491694255 733 3286988
SGTC_407 eburnamonine 100 µM -0.414377606817073 0.324673989510492 no 2277 0.339298793029876 722 3195
SGTC_2686 alizarin 95.37 µM -0.41473748059122 0.324536717694155 no 2278 0.339167045712413 697 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_693 4161-2696 114 µM -0.415806717086638 0.324129004148103 no 2279 0.338775721624343 726 805759
SGTC_2440 5628896 157.78 µM -0.41827559967146 0.323188393722198 no 2280 0.337872813750804 733 5522048
SGTC_1871 st057448 67.3 µM -0.418777095966617 0.322997468307877 no 2281 0.337689522664237 760 691747
SGTC_3079 9117512 49.47 µM -0.419050324968988 0.322893466500622 no 2282 0.337589676824297 753 7185044
SGTC_2094 5332512 191.667 µM -0.419295668771609 0.322800090707626 no 2283 0.337500030789706 753 755774
SGTC_2394 5221648 200 µM -0.419696809743696 0.322647443884485 no 2284 0.337353477981253 732 788586
SGTC_2173 5763948 167 µM -0.42026763605532 0.322430277949246 no 2285 0.337144974882673 720 2867177
SGTC_3050 9093513 49.47 µM -0.420745947390043 0.322248355179848 no 2286 0.336970302813361 740 25236664
SGTC_1249 0481-0015 10.2 µM -0.4220863890441 0.321738753382885 no 2287 0.336480981163934 735 4227577
SGTC_1839 st053978 48 µM -0.423125574616961 0.321343912056102 no 2288 0.336101821988742 717 3788398
SGTC_1780 st038448 24.544 µM -0.42418197668421 0.320942736119859 no 2289 0.335716552020358 758 728868 YDL195W SEC31
SGTC_623 k072-0108 16.9 µM -0.424658460028818 0.320761856647947 no 2290 0.335542834945886 730 5382803
SGTC_1892 st058411 7.36 µM -0.424727687683603 0.320735580439761 no 2291 0.335517598738065 748 3934738
SGTC_1296 1068-0102 11.9 µM -0.42591251794489 0.320286002853672 no 2292 0.335085796531664 736 767053
SGTC_3160 9100216 49.47 µM -0.426475344688182 0.320072533545958 no 2293 0.334880754976883 731 17191039
SGTC_412 gemfibrozil 100 µM -0.426563755359539 0.320039006497017 no 2294 0.334848550847619 717 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3266 9136860 49.47 µM -0.427542675985273 0.319667878999141 no 2295 0.334492054222892 722 4871271 YPR165W RHO1
SGTC_2259 7964009 200 µM -0.428202366069782 0.319417879671055 no 2296 0.334251896914402 723 313134
SGTC_1820 st053765 18.6 µM -0.428443999125901 0.319326329773892 no 2297 0.334163948418542 734 3690829
SGTC_1005 4092-0690 4.4 µM -0.4294637345413 0.318940093944311 no 2298 0.333792890116929 748 1529343
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.430587496284166 0.318514684635538 no 2299 0.333384167207088 703 6708784 An antioxidant flavonoid
SGTC_3016 9080866 49.47 µM -0.430915219613345 0.318390667271805 no 2300 0.333265008313728 756 17066299
SGTC_2496 diffractaic acid 79.83 µM -0.432098672576012 0.317942993412721 no 2301 0.332834849712416 715 94870 An apoptosis inducer which activates caspases.
SGTC_2236 dapsone 200 µM -0.432180827726771 0.31791192581532 no 2302 0.332804996315685 727 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2603 homopterocarpin 100 µM -0.432238068889004 0.317890280390392 no 2303 0.332784196747584 725 101795 A weak amylase inhibitor.
SGTC_2076 5212012 200 µM -0.432675993089374 0.317724702400133 no 2304 0.332625086434385 733 604802
SGTC_7 0192-1582 4.227 µM -0.433956474491667 0.317240764927762 no 2305 0.332160024162888 752 252616
SGTC_2189 6047310 154.431 µM -0.434230978714558 0.317137061071688 no 2306 0.332060359674656 724 711535
SGTC_88 0180-0332 8.668 µM -0.434254293714159 0.317128253652403 no 2307 0.332051895224602 716 3101745
SGTC_1465 k213-0056 144 µM -0.436241696206994 0.316377878350943 no 2308 0.331330689297304 744 24048857 YMR208W ERG12
SGTC_1030 k029-0042 36.7 µM -0.436388519352639 0.316322472872928 no 2309 0.331277433599437 742 6080581
SGTC_3211 9128781 49.47 µM -0.437653977506014 0.31584510805247 no 2310 0.330818568099253 734 17194361
SGTC_2264 7948757 110.76 µM -0.43810646155106 0.315674493375325 no 2311 0.330654555308116 731 2971411
SGTC_735 3076-0345 636 µM -0.438429919291094 0.315552553724561 no 2312 0.330537330862969 713 2888990
SGTC_120 rhodamine 6G 52.259 µM -0.438590211576078 0.315492132914804 no 2313 0.330479245433019 760 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1068 loratadine 26.9 µM -0.439015020088064 0.315332028831612 no 2314 0.330325326493011 735 3957 A H1 histamine antagonist.
SGTC_1311 1190-0148 100 µM -0.442418680909547 0.314050492934582 no 2315 0.329093131690818 737 1961333
SGTC_123 0083-0120 66.675 µM -0.444264539426822 0.313356431304194 no 2316 0.328425667841594 730 16001701
SGTC_2735 sertaconazole 140 nM -0.444521476598465 0.313259872619766 no 2317 0.328332802502371 736 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2522 biochanin a 4.94 µM -0.44470163098367 0.313192177047115 no 2318 0.328267695251228 744 5280373 A possible chelator.
SGTC_3309 9129340 25.759 µM -0.444891267379944 0.313120925274798 no 2319 0.328199166864799 714 17158987
SGTC_862 0452-0056 10.2 µM -0.445081056400624 0.313049623142994 no 2320 0.328130589113216 740 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2714 st079313 56.9 µM -0.445466439166576 0.312904859606062 no 2321 0.327991353975206 730 2939799
SGTC_1611 st001856 99.4 µM -0.447295931113846 0.312218030847838 no 2322 0.32733070221927 765 647478
SGTC_1612 st002233 45.4 µM -0.449262352477085 0.311480523045746 no 2323 0.326621206228033 731 1035021
SGTC_3326 9140064 16.379 µM -0.452337180103916 0.310328822193469 no 2324 0.32551304755848 749 1868434
SGTC_1723 st034307 2.5525 µM -0.452488138523242 0.310272327276131 no 2325 0.325458682192894 719 867466
SGTC_2728 chlorpromazine 9.18 µM -0.454481603635282 0.309526710060256 no 2326 0.324741114895919 778 2726 A thorazine and dopamine antagonist.
SGTC_783 0848-0141 92.7 µM -0.455354941210028 0.309200301538075 no 2327 0.324426953049066 730 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_824 1304-0008 100 µM -0.456358472386068 0.308825419242216 no 2328 0.324066111478233 727 768245
SGTC_736 0958-0254 92.6 µM -0.456458293495861 0.30878814063179 no 2329 0.324030227645858 773 6812352
SGTC_1286 0929-0070 131 µM -0.45751327847007 0.308394272581835 no 2330 0.323651080177049 746 1420408
SGTC_891 0929-0073 133 µM -0.458998051249331 0.307840321056122 no 2331 0.323117782748421 766 5603632
SGTC_3112 9123419 49.47 µM -0.459023200152894 0.307830942057548 no 2332 0.323108752946882 765 17015854
SGTC_3314 9135860 59.4275 µM -0.459154367287739 0.30778202679635 no 2333 0.323061658619356 757 25252478
SGTC_2792 7535235 81.82 µM -0.45983606181239 0.307527862154616 no 2334 0.322816948292454 721 1281891
SGTC_1618 st003135 44.5 µM -0.46130294283714 0.306981260032518 no 2335 0.322290636953535 779 1270615
SGTC_846 0335-0850 148 µM -0.462854196232475 0.306403684738023 no 2336 0.321734440474706 738 6819598
SGTC_3055 9094636 49.47 µM -0.463116676034472 0.306306003627455 no 2337 0.321640368719737 734 25236176
SGTC_3088 9117578 49.47 µM -0.465034514895466 0.305592703436083 no 2338 0.320953369947401 759 678341
SGTC_419 nsc-638432 893 µM -0.465081512886647 0.305575232756207 no 2339 0.320936542238812 742 368090
SGTC_2304 7443016 91.4 µM -0.465114838446589 0.305562844831342 no 2340 0.320924610189748 757 939854
SGTC_3204 9114183 49.47 µM -0.466568644596164 0.305022646371392 no 2341 0.320404262375875 718 17027248
SGTC_2131 toluylene red 5.2905 µM -0.468600084143972 0.30426852488191 no 2342 0.319677758570387 718 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_266 formosanin C 406 nM -0.470262605951519 0.303651973531821 no 2343 0.319083705076167 742 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2293 7624732 200 µM -0.471584486732781 0.303162148339861 no 2344 0.318611700938099 751 894453
SGTC_1993 st073995 70.8 µM -0.472280663642895 0.302904320928923 no 2345 0.318363235169837 745 3098394
SGTC_3008 9078912 71.4286 µM -0.473227201358743 0.302553930552637 no 2346 0.318025546588084 765 16648731
SGTC_785 1270-0111 65.3 µM -0.473325407271413 0.302517586984239 no 2347 0.317990519116346 714 6741994
SGTC_1367 1812-0510 76.9 µM -0.473842745500816 0.302326165277535 no 2348 0.317806025032789 732 1142582 YDR527W RBA50
SGTC_767 0929-0023 86 µM -0.476329543828771 0.301406777729476 no 2349 0.316919810378362 748 1204563
SGTC_3080 9117754 49.47 µM -0.476820012769116 0.301225596461072 no 2350 0.316745146810551 777 9550191
SGTC_1776 st049249 45.9 µM -0.476908675067726 0.301192849475197 no 2351 0.316713577154099 739 1822314
SGTC_2145 5634607 200 µM -0.477347228018147 0.301030895680899 no 2352 0.316557442862959 768 308662
SGTC_3099 9120367 49.47 µM -0.478690854032767 0.300534950813632 no 2353 0.316079286629944 760 24824940
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.478884145672965 0.300463635438314 no 2354 0.316010525207454 746 688662
SGTC_99 0109-0120 622.8 µM -0.479016211071269 0.300414914015471 no 2355 0.315963548021852 763 759414
SGTC_42 0133-0086 60.653 µM -0.479073484345107 0.300393785931333 no 2356 0.315943176181479 777 162923 Model of phenazepam hydroxylation.
SGTC_310 1273-0058 1.06 µM -0.480300412124297 0.29994133418402 no 2357 0.31550689793593 742 2734232
SGTC_953 1188-0045 9.7 µM -0.480710202361484 0.299790285379746 no 2358 0.315361239529494 750 6144426
SGTC_1018 4259-0013 28.1 µM -0.481102334616167 0.299645777571897 no 2359 0.315221884449301 752 6801262
SGTC_2244 6635614 200 µM -0.481888115389243 0.299356298209728 no 2360 0.314942714576383 740 836499
SGTC_1903 st060211 78.3 µM -0.482622884072051 0.299085726362427 no 2361 0.314681763746471 749 688960
SGTC_3043 9092303 49.47 µM -0.482733800922169 0.299044891893381 no 2362 0.314642380004224 743 25236084
SGTC_2482 5981709 142.65 µM -0.482917574001916 0.298977240692754 no 2363 0.314577131515948 762 877755
SGTC_1439 4092-1168 46 µM -0.482958409289638 0.298962209205079 no 2364 0.314562633765185 756 2886240
SGTC_491 tetrandrine 80.3 µM -0.483473076307756 0.29877278947761 no 2365 0.314379936068525 762 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1583 clindamycin 39.6 µM -0.484133768745626 0.298529706068258 no 2366 0.3141454685627 768 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.485091681442483 0.298177428603962 no 2367 0.313805656287261 761 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.485640882387286 0.297975542485728 no 2368 0.313610902596159 725 6708561
SGTC_1960 st011366 51.8 µM -0.485993745512001 0.297845862981651 no 2369 0.313485800213338 748 3972846
SGTC_441 propafenone 146 µM -0.487223895670384 0.297393976149878 no 2370 0.313049836563721 736 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3313 9133968 57.047 µM -0.488123457909586 0.297063726780891 no 2371 0.312731198176413 757 1494643
SGTC_1644 st010134 20.9 µM -0.488732428978985 0.296840255155636 no 2372 0.312515570912174 781 3818134
SGTC_298 1391-0729 10 µM -0.489677040562081 0.296493767226425 no 2373 0.312181225501573 749 3237558
SGTC_1317 1273-0028 910 nM -0.490213091985221 0.296297223532794 no 2374 0.311991558773564 743 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2178 5812956 200 µM -0.490624735217012 0.296146334772852 no 2375 0.311845944212514 749 5403383
SGTC_2247 cerulenin 830 nM -0.491051788559571 0.29598983467247 no 2376 0.311694909560985 725 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_555 4296-0685 37 µM -0.491208094883536 0.295932563369313 no 2377 0.311639637096585 771 2908540 YHR072W ERG7
SGTC_1654 st012436 41.8 µM -0.491402521369781 0.295861331778136 no 2378 0.311570890643649 767 4323132
SGTC_707 0865-0008 204 µM -0.491777146899412 0.295724103281278 no 2379 0.311438446881429 769 723043
SGTC_331 k048-0133 24.5 µM -0.492786829424939 0.295354393764085 no 2380 0.311081608885475 744 6813582
SGTC_253 dyclonine 31.25 µM -0.493086002563126 0.295244888151181 no 2381 0.310975910378026 749 3180 An oral anasthetic.
SGTC_2368 9071271 200 µM -0.493258866805952 0.295181623594592 no 2382 0.310914844179128 770 27209959
SGTC_2934 9036370 36.88 µM -0.494247626476894 0.294819879047207 no 2383 0.310565654034197 731 6462800
SGTC_29 0299-0004 12.984 µM -0.495095628294943 0.294509794625397 no 2384 0.310266309794522 764 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2669 eugenol 100 µM -0.495205584294705 0.294469598611758 no 2385 0.310227504577825 751 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2444 5485484 36.41 µM -0.496274832730411 0.294078851413594 no 2386 0.309850260070479 779 6790631
SGTC_1677 st019204 53.9 µM -0.498215312391935 0.293370333418906 no 2387 0.309166145443213 740 3945625
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.498428976119995 0.293292367775662 no 2388 0.309090858825411 759 23665772 A membrane-active detergent.
SGTC_1802 st050112 57.9 µM -0.49954475286323 0.292885378260305 no 2389 0.30869783369518 744 4662563
SGTC_1844 rapamycin 4 nM -0.500198569711124 0.292647014606151 no 2390 0.308467632686577 773 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1829 berberine 14.4 µM -0.501507780781301 0.29216998332086 no 2391 0.308006901639858 764 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1446 4239-0190 62 µM -0.501612847052524 0.292131716489879 no 2392 0.307969940340654 768 1340085
SGTC_1145 3546-0597 10.2 µM -0.503653322583325 0.291389005331866 no 2393 0.307252507392531 747 875334
SGTC_1724 st037281 8.293 µM -0.503965396047453 0.291275491667226 no 2394 0.307142847010852 737 574124 YDL195W SEC31
SGTC_285 1486-1325 46 µM -0.504444877614108 0.291101125175831 no 2395 0.306974394226261 752 22310230
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.506005867379201 0.290533799393658 no 2396 0.306426265360098 765 279621
SGTC_2197 6588183 93.1375 µM -0.506531207174263 0.290342986445609 no 2397 0.306241893845278 754 884136
SGTC_380 3970-0968 6 µM -0.506748326526776 0.290264141898606 no 2398 0.306165708680744 762 2891601
SGTC_620 0109-0052 432 µM -0.507369714938138 0.290038546852067 no 2399 0.305947715588107 776 493037
SGTC_1348 1493-0373 93.8 µM -0.507513097175278 0.289986503607511 no 2400 0.305897424538199 786 3010129
SGTC_1635 st007035 42.4 µM -0.507984067298363 0.28981558707653 no 2401 0.305732258409559 768 3716403
SGTC_316 k060-0003 58.6 µM -0.508029741739891 0.289799014192915 no 2402 0.305716242784141 771 6152314
SGTC_2567 aureobasidin a 60 nM -0.508539012188991 0.289614256509993 no 2403 0.305537693589322 752 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2995 9067767 71.4286 µM -0.50856971616532 0.289603119214818 no 2404 0.305526930314452 770 11673567
SGTC_132 0417-1715 25.805 µM -0.508582997993692 0.289598301541415 no 2405 0.305522274423335 786 6769098
SGTC_1019 4262-0212 3.4 µM -0.509257856323945 0.289353561965663 no 2406 0.305285746980187 772 4677213
SGTC_75 0159-0059 199.013 µM -0.509810478645308 0.289153224079448 no 2407 0.305092121896979 809 5377270
SGTC_2360 9040895 200 µM -0.510092963778821 0.289050842129974 no 2408 0.304993167212795 745 4914414
SGTC_1100 amiodarone 5.07 µM -0.510497790362634 0.288904149329253 no 2409 0.304851381115744 745 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.510974145003278 0.288731582529857 no 2410 0.304684580619391 785 688801
SGTC_615 k087-0205 167 µM -0.511540315858492 0.288526541573107 no 2411 0.304486382848299 773 9642773
SGTC_1352 1496-0991 99 µM -0.513639044024659 0.287767078267475 no 2412 0.303752188299334 786 3000039
SGTC_1333 1482-0047 286 µM -0.514177810666497 0.287572268118247 no 2413 0.303563839972143 784 3811116
SGTC_2872 9044037 25.97 µM -0.514722603039622 0.287375342570644 no 2414 0.303373438147529 771 6465195
SGTC_971 1315-0384 26.7 µM -0.514855221892508 0.287327414624546 no 2415 0.303327096693295 782 6769120
SGTC_1281 0884-0031 11.8 µM -0.514966748181358 0.287287112378129 no 2416 0.303288128134249 758 1548255
SGTC_2111 5486399 200 µM -0.515028400624609 0.287264834187631 no 2417 0.303266587026979 755 689674
SGTC_2157 5649910 96.377 µM -0.515597802064976 0.287059118890434 no 2418 0.303067672868919 770 2858091
SGTC_3267 9137951 49.47 µM -0.516013453739452 0.286908994898086 no 2419 0.302922506373615 769 16643986
SGTC_1990 st072050 59.8 µM -0.517467881227248 0.286383981580272 no 2420 0.302414792236758 759 17233948
SGTC_157 1348-1695 65.819 µM -0.519328233254569 0.28571310469368 no 2421 0.301765934103966 729 5380510
SGTC_1131 3454-3128 32.3 µM -0.51952846709707 0.285640941305182 no 2422 0.301696133374805 743 710982
SGTC_1672 st016598 6.51 µM -0.519569846360617 0.285626029483584 no 2423 0.301681709631657 778 4665860 YNL267W PIK1
SGTC_2062 5245942 200 µM -0.52066962543268 0.285229838552892 no 2424 0.301298468738534 759 1376160
SGTC_3129 9127257 49.47 µM -0.520750541898237 0.285200699070814 no 2425 0.301270280373536 791 837894
SGTC_2089 5281248 129.67 µM -0.521061872302546 0.285088596595469 no 2426 0.301161835217911 758 2737878
SGTC_1357 1503-1303 39.5 µM -0.522304751616118 0.284641275552208 no 2427 0.300729080682305 763 292895
SGTC_613 3914-0030 117 µM -0.522742804859424 0.284483697000496 no 2428 0.300576623105171 752 1145395
SGTC_2682 pyrogallin 40.03 µM -0.523860846017752 0.284081699046433 no 2429 0.300187664666672 764 822798 An ATP competetive kinase inhibitor.
SGTC_2713 st079149 53.4 µM -0.528539430992153 0.282402441724931 no 2430 0.298562493371381 754 3103253
SGTC_1518 st038567 90.8 µM -0.528774350663552 0.282318249418135 no 2431 0.298480996384978 783 77966
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.529615697586091 0.28201682019504 no 2432 0.298189204202329 784 688788
SGTC_44 0929-0055 61.211 µM -0.529689652716549 0.281990331715484 no 2433 0.298163561627416 732 1379590
SGTC_2908 7930301 100 µM -0.52982455330058 0.281942017513874 no 2434 0.298116789929962 772 2223178
SGTC_2034 5197015 53.07 µM -0.530556718737302 0.281679864441748 no 2435 0.297862997458809 794 780676
SGTC_2677 mitomycin C 100 µM -0.530618991812475 0.281657572886057 no 2436 0.297841416122471 783 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2731 amoxapine 43.43 µM -0.530748122498836 0.281611351384023 no 2437 0.297796666907076 798 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1048 3161-0300 24.5 µM -0.530881700648442 0.281563541790475 no 2438 0.297750379685646 745 2165101
SGTC_1420 4'-methoxyflavone 42 µM -0.532033343293328 0.281151514326669 no 2439 0.297351451080123 771 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3006 9075424 71.4286 µM -0.533471027726849 0.280637557674606 no 2440 0.296853780672639 770 7465181
SGTC_1149 3909-7961 23.3 µM -0.534262091864649 0.28035495478508 no 2441 0.296580107732239 741 735261
SGTC_1096 rimcazole 32.2 µM -0.534482391327387 0.28027627867074 no 2442 0.296503914515917 766 18528119 A dopamine reuptake inhibitor.
SGTC_2828 7998861 71.43 µM -0.534618381483973 0.280227717494892 no 2443 0.296456885164101 747 2988188
SGTC_1306 1185-0270 9.02 µM -0.535519346274509 0.279906091988976 no 2444 0.296145391724682 781 1548076
SGTC_698 k064-0052 127 µM -0.535788576009589 0.27981001737976 no 2445 0.296052339217194 793 5088751
SGTC_2869 9037858 32.47 µM -0.536695569097211 0.279486474741873 no 2446 0.295738958596873 750 27187042
SGTC_3318 9139014 38.6185 µM -0.537668769728478 0.279139516718822 no 2447 0.295402871831564 786 16643984
SGTC_197 4544-0043 41.561 µM -0.537748105863827 0.279111241642022 no 2448 0.29537548150274 779 896523
SGTC_1959 st077091 55.8 µM -0.538974055432008 0.278674495294081 no 2449 0.294952378321686 787 821356 YKL052C ASK1
SGTC_2323 6148992 148.28 µM -0.539337007414689 0.278545256981418 no 2450 0.294827168905403 766 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_721 1187-1332 279 µM -0.540180448968733 0.278245040896848 no 2451 0.294536297194711 780 25730
SGTC_3152 9099253 49.47 µM -0.541243027498267 0.277867049523334 no 2452 0.294170041887909 778 25236131
SGTC_2437 5741531 144.16 µM -0.54139182587594 0.277814137448338 no 2453 0.29411877006155 791 2262990
SGTC_1171 0368-0077 21.4 µM -0.541845141462305 0.27765297066828 no 2454 0.293962595446051 768 3239779
SGTC_2616 abietic acid 100 µM -0.542464824167515 0.277432729492325 no 2455 0.293749166702296 792 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1615 st002656 86.5 µM -0.543708668327106 0.276990913266561 no 2456 0.293320983217641 768 1584458
SGTC_675 1309-0189 238 µM -0.544576285259797 0.276682937849022 no 2457 0.293022484325126 759 4246530
SGTC_486 niguldipine 82 µM -0.545608238527629 0.276316847065104 no 2458 0.29266763001525 775 1236 A calcium channel blocker.
SGTC_1873 rapamycin 2 nM -0.547173649256179 0.275761963531299 no 2459 0.292129718875758 752 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_399 oxolinic acid 75 µM -0.548622909725364 0.275248739878967 no 2460 0.29163213017819 748 4628 A DNA gyrase inhibitor.
SGTC_114 0364-0001 490.298 µM -0.54921300680389 0.275039904788985 no 2461 0.291429639660862 779 4003655
SGTC_3026 9090633 49.47 µM -0.549937383094256 0.274783655103198 no 2462 0.291181161241158 774 25236842
SGTC_2192 5915882 198.485 µM -0.550063801792888 0.274738946279739 no 2463 0.29113780673945 770 2876149
SGTC_1935 st074532 41.6 µM -0.550177783167009 0.274698639074779 no 2464 0.291098720124747 783 2829742
SGTC_270 tamoxifen 5.46 µM -0.550180285946656 0.274697754050155 no 2465 0.291097861896374 786 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2572 astragaloside iv 100 µM -0.550962615572175 0.274421178180457 no 2466 0.290829651118615 767 45006101 An anti-inflammatory agent.
SGTC_3223 9129970 49.47 µM -0.551845199277668 0.274109324706054 no 2467 0.290527208386456 768 17248386
SGTC_1882 5615643 20 µM -0.552345318301902 0.273932689635093 no 2468 0.290355893553736 775 2253075
SGTC_2109 5483026 200 µM -0.553309345002366 0.273592367672558 no 2469 0.290025801554094 808 759335
SGTC_2299 7976368 114.88 µM -0.55514218666147 0.272945913095818 no 2470 0.289398704618627 774 2979718
SGTC_850 0388-0143 75.9 µM -0.555789918749957 0.272717635252825 no 2471 0.289177239000614 795 67273
SGTC_1687 st020778 55.3625 µM -0.556375468290857 0.272511353739418 no 2472 0.28897710277388 759 4259299
SGTC_691 1548-0686 185 µM -0.55701976278511 0.272284466697759 no 2473 0.288756963315318 796 46495133
SGTC_977 1348-1378 135 µM -0.560522713069566 0.271052554449812 no 2474 0.287561475854964 789 X977
SGTC_711 k292-0785 179 µM -0.561811730667157 0.270599935443842 no 2475 0.287122149409227 785 4146315
SGTC_851 0394-0702 453 µM -0.562297151986565 0.270429585004742 no 2476 0.28695678921727 794 762646
SGTC_450 aminopyrene 156 nM -0.563550595496505 0.269989958120511 no 2477 0.286530008802863 793 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_935 2996-0153 430 µM -0.564324297751837 0.269718772058511 no 2478 0.286266724132276 796 23738523
SGTC_1716 st033144 30.6155 µM -0.564517817601483 0.269650963830486 no 2479 0.286200888844042 808 674617
SGTC_34 0469-0683 81.75 µM -0.565352914455703 0.269358448732011 no 2480 0.28591687210568 771 3690923
SGTC_1754 st042065 16.137 µM -0.566559380710806 0.26893613268516 no 2481 0.285506789276984 795 1126236 YIL048W NEO1
SGTC_2400 5203494 178.7 µM -0.566679951134997 0.268893946032317 no 2482 0.28546582228951 794 6777674
SGTC_2263 7948595 193.29 µM -0.567989806016717 0.268435852246448 no 2483 0.285020944942784 758 2971371
SGTC_1969 st069479 40.1 µM -0.569250963266184 0.267995160526942 no 2484 0.284592919824508 799 3895485
SGTC_2032 5185112 25.99 µM -0.569854809681435 0.267784284859783 no 2485 0.284388088650688 765 5718189
SGTC_460 trequinsin 123 µM -0.569892712031196 0.26777105136364 no 2486 0.284375234117528 795 5537 A vasodilator.
SGTC_1968 st069590 43.6 µM -0.57022909189821 0.267653619743484 no 2487 0.284261163486656 789 6384066
SGTC_822 1487-0950 154 µM -0.570767354033622 0.267465764193655 no 2488 0.284078677564807 764 1958375
SGTC_1564 D-Arginine 115 µM -0.570941817210082 0.267404890147763 no 2489 0.284019541694482 818 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.571366223945166 0.26725683447157 no 2490 0.283875709791054 782 94937 An inhibitor of serotonin biosynthesis.
SGTC_14 0354-0009 295 µM -0.57228223792932 0.266937421059386 no 2491 0.283565390543364 797 1713507
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.572420236362999 0.266889317824278 no 2492 0.283518654726278 784 676296 Flavone; oxidizing agent.
SGTC_56 0957-0365 83.25 µM -0.574117701214893 0.266297977173696 no 2493 0.282944077860488 767 6752360
SGTC_2380 9035439 200 µM -0.575175411457358 0.265929841505158 no 2494 0.28258633523479 775 6462575
SGTC_1915 st067105 30.6 µM -0.575298600286441 0.265886982448238 no 2495 0.282544683999214 798 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1658 st012944 20 µM -0.576871076849867 0.265340204301702 no 2496 0.282013275189346 791 24207260
SGTC_1801 st050089 28.441 µM -0.577516478504706 0.26511595194322 no 2497 0.28179530507344 782 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1406 3909-7906 11.9 µM -0.577602762469211 0.265085978866555 no 2498 0.281766170729607 783 X1406
SGTC_174 3553-0389 74.3 µM -0.578241315998455 0.264864213488073 no 2499 0.28155060410565 766 738071
SGTC_2921 7974240 10.71 µM -0.578606752793113 0.264737342168382 no 2500 0.281427273621267 791 2979074 YDR527W RBA50
SGTC_2674 ligustilide 100 µM -0.579950583695049 0.26427106064058 no 2501 0.280973971324268 762 5319022 A signalling regulator.
SGTC_2274 7947094 46.08 µM -0.581177912320494 0.263845568672578 no 2502 0.280560276219992 771 2971028
SGTC_1817 st052116 64.4 µM -0.581921947583597 0.263587795668812 no 2503 0.280309628180653 780 4361398
SGTC_2954 9074818 52.69 µM -0.582644079316917 0.263337734140424 no 2504 0.280066462681759 812 16648742
SGTC_3154 9100113 49.47 µM -0.582989648720172 0.263218112397686 no 2505 0.27995013428292 796 25237525
SGTC_534 k292-0788 63.4 µM -0.583169104763901 0.263156003136869 no 2506 0.279889733565521 807 4146317
SGTC_1877 wortmannin 25 µM -0.584392092719948 0.262732929726946 no 2507 0.279478272738611 792 312145 A covalent inhibitor of PI 3-kinase.
SGTC_345 1362-0200 395 µM -0.586535916105002 0.261992148254122 no 2508 0.278757716524674 791 1419823
SGTC_2864 9034755 47.6 µM -0.588046133747291 0.26147094790691 no 2509 0.278250663753185 777 4930451
SGTC_1432 4049-0298 68.4 µM -0.588119213206427 0.261445740523751 no 2510 0.278226138871487 804 741646
SGTC_1689 st020265 53.493 µM -0.588298817051778 0.261383794862139 no 2511 0.27816586973684 798 5758320 YPR016C TIF6
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.588406179219757 0.261346769073972 no 2512 0.278129845570444 791 688761
SGTC_3315 9136395 68.55 µM -0.588726416932951 0.261236345302561 no 2513 0.27802240693042 823 16876844
SGTC_3297 9117502 71.43 µM -0.58985323520196 0.260847988596714 no 2514 0.277644524380909 782 7453720
SGTC_62 0180-0423 3.232 µM -0.590523698855367 0.260617055023414 no 2515 0.277419801110861 821 30102 YGL099W LSG1
SGTC_2474 5321570 43.32 µM -0.59183591927105 0.2601653803864 no 2516 0.276980233917238 802 2841384
SGTC_2460 5552655 174.22 µM -0.592087971159849 0.260078668735016 no 2517 0.276895840705643 794 5401989
SGTC_2082 5219693 150 µM -0.592980540074388 0.259771724334629 no 2518 0.276597087823943 792 2834649
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.593092447782299 0.25973325372593 no 2519 0.276559642201217 792 2724278 An inhibitor of dopamine biosynthesis.
SGTC_663 1486-0733 13.9 µM -0.593226832806892 0.259687059956558 no 2520 0.276514678690648 803 722445 YPR165W RHO1
SGTC_3132 9126706 49.47 µM -0.593368347319545 0.259638420067473 no 2521 0.276467333619234 826 850858
SGTC_2070 5230947 200 µM -0.593980961718447 0.259427912910198 no 2522 0.276262423312011 814 2835538
SGTC_3020 9089140 49.47 µM -0.594006899184092 0.259419002198686 no 2523 0.276253749264302 794 17217859
SGTC_2240 6690706 185.951 µM -0.594394462559405 0.259285875200254 no 2524 0.276124155635428 781 805876
SGTC_2835 9006588 71.43 µM -0.598478350316423 0.257885219561344 no 2525 0.274760400202525 766 2345538
SGTC_868 0527-0199 213 µM -0.598966418190356 0.257718089385889 no 2526 0.274597639393166 796 2849450
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.598967266914773 0.257717798804267 no 2527 0.27459735640209 807 165521
SGTC_1303 1160-0052 261 µM -0.599896774866953 0.257399661081524 no 2528 0.274287515969198 792 3562476
SGTC_1046 2001-0062 216 µM -0.600988198878306 0.257026365855871 no 2529 0.2739239232274 807 739778
SGTC_2280 7785178 200 µM -0.604673845262523 0.255767863743537 no 2530 0.2726978649074 791 2954328
SGTC_2424 5537928 59.2 µM -0.605324109881507 0.25554615848211 no 2531 0.272481832385572 810 5382802
SGTC_1746 st038117 42 µM -0.606034052848744 0.255304220796551 no 2532 0.272246070457227 794 2898218
SGTC_3290 9121031 71.43 µM -0.60934528207111 0.254177388153442 no 2533 0.271147799265697 794 17014854
SGTC_2451 5856223 45.7 µM -0.610080946964575 0.253927391229667 no 2534 0.270904093621968 807 2179896
SGTC_1748 st037455 53.6035 µM -0.610268695333556 0.253863610416594 no 2535 0.270841915238099 812 580690
SGTC_743 1275-0778 158 µM -0.611345365678075 0.253498012504886 no 2536 0.270485481852489 807 2849257 YMR203W TOM40
SGTC_493 zm226600 134 µM -0.612205113434481 0.253206272358434 no 2537 0.270201029427775 823 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3082 9117008 49.47 µM -0.613805647905515 0.252663630046216 no 2538 0.269671882309992 805 41448529
SGTC_2970 9090938 41.86 µM -0.616882584238621 0.2516221541727 no 2539 0.268656087433055 786 17217104
SGTC_969 1313-0238 134 µM -0.618952576165629 0.250922785073104 no 2540 0.267973800512006 818 5212874
SGTC_852 0418-0143 439 µM -0.620658423259889 0.250347220422042 no 2541 0.267412195341614 799 5369229
SGTC_800 3448-7362 155 µM -0.621381368411122 0.250103505035303 no 2542 0.267174363957035 814 15991913
SGTC_2793 7325131 81.82 µM -0.621472250899235 0.250072876127066 no 2543 0.267144473383649 788 4176441
SGTC_2653 dihydrofissinolide 100 µM -0.62210504322296 0.249859669778605 no 2544 0.266936399509362 797 6857746
SGTC_2140 5586273 200 µM -0.622738903750131 0.249646200297463 no 2545 0.266728056492371 808 854421
SGTC_1835 st008666 49.2 µM -0.624759332368597 0.248966413954293 no 2546 0.266064512711063 801 690455
SGTC_2161 5662504 8.5105 µM -0.624942413508311 0.248904863826225 no 2547 0.26600442702766 800 2859334
SGTC_1727 st034309 9.9045 µM -0.625732840636656 0.248639222777043 no 2548 0.265745094443887 813 870305
SGTC_1668 st014914 51.6 µM -0.627031238821718 0.248203194443474 no 2549 0.265319379144038 810 2839556
SGTC_1755 st041960 45.185 µM -0.627186897180699 0.248150948609789 no 2550 0.265268365548634 824 2257073
SGTC_1277 0873-0036 22 µM -0.627774530471669 0.247953765754122 no 2551 0.265075826586587 809 5965735
SGTC_1661 st013063 9.66 µM -0.630081974363376 0.247180302585877 no 2552 0.264320476290619 830 721395
SGTC_1166 k206-0078 225 µM -0.630393003171723 0.247076143427985 no 2553 0.264218743735876 800 5404595
SGTC_2807 7945238 51.95 µM -0.631207453022991 0.246803506945461 no 2554 0.263952444707966 808 17148797
SGTC_2072 5231554 129 µM -0.631213204329534 0.2468015822727 no 2555 0.263950564701377 816 789545
SGTC_550 4123-0385 25.7 µM -0.631455636106958 0.246720459870059 no 2556 0.263871323987501 814 5731123
SGTC_121 0557-0495 61.343 µM -0.632706809197682 0.246302020032792 no 2557 0.263462561221145 833 3104427
SGTC_1771 st048882 4.1505 µM -0.6330199204884 0.246197363264966 no 2558 0.263360317219068 792 4580403
SGTC_142 0335-0849 62.6745 µM -0.633196708190892 0.246138282894697 no 2559 0.263302597550668 803 3889043 YPR107C YTH1
SGTC_1125 tnp00248 1.32998 µM -0.63355584436634 0.246018287226885 no 2560 0.263185362564983 810 24207736
SGTC_173 1273-0061 2.693 µM -0.634068851217715 0.245846934272552 no 2561 0.263017944910607 811 2847414 YPL266W DIM1
SGTC_881 0833-0569 170 µM -0.634552569359665 0.245685422938991 no 2562 0.262860135379246 789 5418700
SGTC_291 SEC14.278 35.5 µM -0.634845174188214 0.245587751154319 no 2563 0.262764698686316 806 1068044
SGTC_1421 4029-0249 71.4 µM -0.634863933951585 0.245581489838052 no 2564 0.262758580561516 818 2894095
SGTC_1376 2910-0861 41.3 µM -0.635910495191367 0.2452323222048 no 2565 0.262417380825406 825 1112859
SGTC_2183 6420625 130.508 µM -0.636136405694957 0.245156985990053 no 2566 0.262343759298375 808 2897619
SGTC_455 paf C-16 10 µM -0.636288018186221 0.245106433518219 no 2567 0.262294356535912 802 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_758 0868-0029 16 µM -0.636768119637658 0.244946389274865 no 2568 0.262137947451867 792 762687
SGTC_1334 1486-0610 236 µM -0.636891391791892 0.244905304953946 no 2569 0.262097795143003 795 3742339
SGTC_1648 st011736 69.8 µM -0.637589887768868 0.24467257926213 no 2570 0.261870339997258 809 2855514
SGTC_2638 epoxomicin 18 µM -0.637880187188452 0.244575892010291 no 2571 0.261775837964271 806 9915668 A protesome inhibitor.
SGTC_2162 5663267 200 µM -0.638557898779104 0.244350253213984 no 2572 0.261555288610391 822 6456493
SGTC_1360 1598-0022 39.8 µM -0.639259258823822 0.244116859031319 no 2573 0.261327143759155 823 761525
SGTC_335 4077-0256 27.6 µM -0.642018045661855 0.243199974956633 no 2574 0.260430733085505 825 3121989
SGTC_1293 1000-1278 195 µM -0.642133086387632 0.243161781596755 no 2575 0.260393387408834 827 678847
SGTC_1041 0206-0046 107 µM -0.642423618889786 0.243065339651742 no 2576 0.260299084109457 828 50494
SGTC_8 0354-0001 70 µM -0.642718450969134 0.242967491618767 no 2577 0.260203403212097 803 4993152
SGTC_2375 9072683 200 µM -0.643919501145609 0.242569110795966 no 2578 0.259813817702049 831 16798029
SGTC_2035 5154463 94.595 µM -0.645415091100755 0.242073527881801 no 2579 0.259329113177381 830 2769623
SGTC_1000 4048-0884 8.67 µM -0.646877840544031 0.24158935868015 no 2580 0.258855504260491 822 13040088
SGTC_903 1134-0042 114 µM -0.648223030400409 0.241144566156996 no 2581 0.258420354138749 822 701009
SGTC_641 4092-0595 30 µM -0.648838976468825 0.240941049757715 no 2582 0.258221230758301 822 786260
SGTC_1029 k015-0030 64.7 µM -0.649402871935282 0.240754813482378 no 2583 0.258039004086214 813 2208316
SGTC_2224 6650123 117.647 µM -0.652397401053884 0.239767132050027 no 2584 0.257072420253538 816 2908370
SGTC_2316 5844804 197.44 µM -0.652493125416066 0.239735595921562 no 2585 0.257041553122721 811 776813
SGTC_26 0302-0163 425.158 µM -0.652659988270188 0.239680628823938 no 2586 0.25698775139249 848 3100915
SGTC_769 0302-0231 76 µM -0.653743120563787 0.23932399627127 no 2587 0.256638658624508 837 571869 YER009W NTF2
SGTC_71 0417-1750 47.813 µM -0.654056115578714 0.239220993424722 no 2588 0.256537826563273 791 6811472
SGTC_665 3914-0008 307 µM -0.654298648104229 0.239141195585157 no 2589 0.256459708347268 819 1069549
SGTC_3140 9094243 49.47 µM -0.654884157693538 0.238948611698624 no 2590 0.256271170443599 836 19291112
SGTC_1846 st056244 14.8 µM -0.656396573633355 0.238451545505137 no 2591 0.255784497229636 823 5393182
SGTC_3135 9127742 49.47 µM -0.656414696768894 0.238445592643117 no 2592 0.255778668397757 828 3643468
SGTC_1848 st056003 16.4 µM -0.657390486755412 0.238125197455968 no 2593 0.255464933510174 802 146492
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.658021809347855 0.237918031971252 no 2594 0.255262058568023 808 2333 A French combination drug.
SGTC_713 1488-1073 324 µM -0.658728117650843 0.23768637745527 no 2595 0.255035186906311 832 3312542
SGTC_2497 7-hydroxyflavone 100 µM -0.659214974251768 0.237526770633559 no 2596 0.25487886625766 838 5281894
SGTC_1947 st076332 61.6 µM -0.660511564408741 0.23710199490695 no 2597 0.254462799883235 833 24208416
SGTC_1402 3909-7673 35.9 µM -0.660705002735492 0.237038658403135 no 2598 0.254400757450456 808 5328014
SGTC_923 1900-2434 73.3 µM -0.6625549333308 0.236433415159267 no 2599 0.253807820731064 846 5910570
SGTC_1832 st054113 55 µM -0.66273288035681 0.236375240972239 no 2600 0.253750823716424 815 1251267
SGTC_1290 0986-0249 10.2 µM -0.663236572825284 0.236210617279515 no 2601 0.253589525812967 832 53329
SGTC_3114 9122766 49.47 µM -0.663435057880254 0.236145763015266 no 2602 0.25352597955762 793 17176985
SGTC_309 k408-0051 1.48 µM -0.66392015405053 0.235987300907635 no 2603 0.253370708144269 827 3640463
SGTC_1986 st071812 45 µM -0.664634420039497 0.235754084606265 no 2604 0.253142174206283 830 11838594
SGTC_2006 4011487 200 µM -0.664818972438153 0.235693846730601 no 2605 0.253083143125249 826 45595294
SGTC_2772 vinpocetine 57.06 µM -0.665374379623151 0.235512613130097 no 2606 0.252905533828313 843 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1283 0922-0125 16.4 µM -0.665820876435589 0.235366973585818 no 2607 0.252762799704983 807 3360884
SGTC_1278 0874-0585 172 µM -0.666014060870597 0.235303975572237 no 2608 0.252701056509009 813 766306
SGTC_299 1273-0059 1.44 µM -0.666268644364518 0.235220969363326 no 2609 0.252619701844803 818 2848077
SGTC_1939 st074455 53.6 µM -0.66854579720147 0.234479229850622 no 2610 0.25189262924576 833 1644229
SGTC_1146 3579-1023 7 µM -0.668888549871333 0.234367696797688 no 2611 0.251783287392489 843 X1146
SGTC_118 0083-0097 135.343 µM -0.669337570287635 0.234221628241145 no 2612 0.251640082892879 853 5207356
SGTC_3355 9151058 44.0485 µM -0.669563176359609 0.234148256500046 no 2613 0.251568147384656 824 17015728
SGTC_1722 st034304 3.6505 µM -0.670067131523254 0.233984405877438 no 2614 0.251407498266901 836 4036148 YLR033W RSC58
SGTC_2736 butenafine 14.65 µM -0.671406739172603 0.233549169064216 no 2615 0.250980726460765 826 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1778 st046819 58.9 µM -0.67233145201758 0.233248993165141 no 2616 0.250686355525136 837 671715
SGTC_1984 st072354 53.1 µM -0.673415646156604 0.232897320076433 no 2617 0.250341448704835 820 5762938
SGTC_378 3970-0959 8.33 µM -0.673491757617618 0.232872643360021 no 2618 0.250317245371119 834 6615653
SGTC_700 3453-2283 142 µM -0.673583721464161 0.23284282895059 no 2619 0.250288002657057 831 565664
SGTC_1452 4194-0072 190 µM -0.674384531830138 0.23258329823554 no 2620 0.250033437118132 830 1343545
SGTC_1341 1486-1360 280 µM -0.674811541095432 0.232444976659636 no 2621 0.24989775348908 840 3976547
SGTC_964 1287-0107 19.4 µM -0.67489988965063 0.232416363529281 no 2622 0.249869685319087 813 51516812 YPR165W RHO1
SGTC_36 0335-0881 14.2 µM -0.675343023044837 0.232272877062131 no 2623 0.249728927923153 818 23828853
SGTC_81 0411-0046 9.971 µM -0.676109237676519 0.23202489331365 no 2624 0.249485646016556 825 12925265
SGTC_1514 1189-1591 158 µM -0.67683867530648 0.231788949390327 no 2625 0.249254158299232 849 767698 YMR146C TIF34
SGTC_938 3126-1755 342 µM -0.677309181945881 0.231636830236831 no 2626 0.249104903190703 817 1777771
SGTC_177 1327-0068 8.361 µM -0.67752009192484 0.231568659151912 no 2627 0.2490380133182 827 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1220 1838-0075 193 µM -0.677799422337536 0.231478390183368 no 2628 0.248949438690472 811 5529645
SGTC_572 0960-0087 17.7 µM -0.678361585762851 0.231296779825915 no 2629 0.24877122960923 849 6796365
SGTC_2583 asiatic acid 100 µM -0.680438148940219 0.230626622788068 no 2630 0.248113536273401 850 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3301 9125354 19.7965 µM -0.681269446257221 0.230358647490689 no 2631 0.247850506293538 808 41905162
SGTC_485 niflumic acid 177 µM -0.681377589325368 0.230323799515042 no 2632 0.247816299794576 836 4488 A COX2 inhibitor.
SGTC_2644 guaiazulene 100 µM -0.683682980341442 0.22958161294415 no 2633 0.247087686498723 814 3515 A coloring agent.
SGTC_428 3448-4153 16.5 µM -0.683891403661819 0.229514580241966 no 2634 0.247021871338555 818 3834874
SGTC_1610 st001799 48.1 µM -0.684926234045507 0.229181922561542 no 2635 0.24669523529343 832 621897
SGTC_346 4513-0042 7.16 µM -0.68524746193535 0.229078715322384 no 2636 0.246593889306262 823 2827372
SGTC_2194 5927483 104.545 µM -0.68638572802079 0.228713212009534 no 2637 0.246234950957572 799 760979
SGTC_1507 4075-3230 155 µM -0.688124271108061 0.228155589055326 no 2638 0.245687263704241 827 659771
SGTC_3007 9078383 71.4286 µM -0.689731670297206 0.227640710200625 no 2639 0.245181472837431 825 6496995
SGTC_1455 4262-0120 131 µM -0.690119717135701 0.22751650991781 no 2640 0.245059452371744 836 1529587
SGTC_876 0720-0963 56.8 µM -0.690247048968557 0.227475763748529 no 2641 0.245019420278988 843 765861
SGTC_2805 7950783 58.44 µM -0.691535001071506 0.227063850362162 no 2642 0.244614696444134 830 1178958 YDL195W SEC31
SGTC_3311 9131146 2.8755 µM -0.693130104034671 0.226554287293714 no 2643 0.244113953543601 835 4900406 YPR165W RHO1
SGTC_1394 3474-0001 65.7 µM -0.695006950330004 0.225955547530272 no 2644 0.243525472935196 812 5017666 YIL048W NEO1
SGTC_2467 5474540 200 µM -0.695219144842541 0.225887910900676 no 2645 0.243458988108121 816 5413519
SGTC_1291 0993-0025 5.79 µM -0.6953325085608 0.225851781106345 no 2646 0.243423472984466 828 4353356
SGTC_2983 9022671 12.99 µM -0.695565104816639 0.225777661317193 no 2647 0.243350612890065 823 6405161
SGTC_1326 1431-2094 10.8 µM -0.695670348335542 0.225744128637654 no 2648 0.243317649539732 852 616278
SGTC_1647 st011722 22.4 µM -0.696311912480013 0.225539774477132 no 2649 0.243116757268253 828 2854783
SGTC_1391 3442-0225 151 µM -0.696435535833836 0.225500409394018 no 2650 0.243078057533016 825 5227075
SGTC_2399 5884133 200 µM -0.699673070033557 0.224470874782059 no 2651 0.242065749071248 833 722445
SGTC_759 3486-0358 89.3 µM -0.701404146134712 0.223921489484365 no 2652 0.241525417619709 845 875103
SGTC_24 0417-1663 219 µM -0.702105117297861 0.223699242353384 no 2653 0.241306805629487 858 4329390
SGTC_1614 st002383 48.6 µM -0.703856350079521 0.22314455184801 no 2654 0.240761118541921 817 1947235
SGTC_749 1000-0129 128 µM -0.704451272557294 0.222956292742315 no 2655 0.240575892621413 846 708470
SGTC_260 nsc-65238 3.989 µM -0.705699487406331 0.222561597957563 no 2656 0.24018751990913 842 3246252
SGTC_1236 0330-0013 258 µM -0.705833134703936 0.222519361315599 no 2657 0.240145956813638 842 4617066
SGTC_2607 solasodine 47.35 µM -0.705862023021223 0.222510232322769 no 2658 0.240136973324684 851 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_946 3434-1334 87.4 µM -0.706277967022872 0.222378813597835 no 2659 0.240007646246656 830 4047976
SGTC_2235 salicylic acid 500 µM -0.706706918966983 0.222243331360472 no 2660 0.23987431447161 833 338 A COX inhibitor and kinase inhibitor.
SGTC_573 3702-0553 84.7 µM -0.706717339792571 0.222240040583089 no 2661 0.23987107585355 834 1222756
SGTC_1779 st039427 55 µM -0.707424081507298 0.222016924538095 no 2662 0.239651488035463 851 1124498
SGTC_2730 imipramine 71.33 µM -0.708357867975571 0.221722327409172 no 2663 0.239361524717845 829 3696 A tricyclic antidepressant.
SGTC_2635 hydroquinidine 100 µM -0.708747082561697 0.22159960139449 no 2664 0.239240720767638 827 442912 An experimental heart treatment.
SGTC_3268 9137683 49.47 µM -0.709113940934976 0.221483960226094 no 2665 0.239126886215357 885 1953228
SGTC_2003 4023581 200 µM -0.709909166190647 0.221233407641899 no 2666 0.238880232954943 850 16641307
SGTC_2806 7952793 58.44 µM -0.710602784834138 0.221015000818863 no 2667 0.238665208452625 848 2972490
SGTC_429 1112-0049 25.5 µM -0.711814342812251 0.220633801302405 no 2668 0.238289874931065 842 2836170
SGTC_2788 5282734 71.43 µM -0.711831280816918 0.220628474670705 no 2669 0.238284629929695 845 743706
SGTC_2893 9048488 25.97 µM -0.712150728149715 0.220528029274577 no 2670 0.23818572211149 859 6467338
SGTC_508 roscovitine 141 µM -0.714739287163571 0.219715062986885 no 2671 0.237385078374928 860 160355 A CDKinase inhibitor.
SGTC_400 oxethazaine 37.5 µM -0.719061385742001 0.218361501249747 no 2672 0.236051548978963 836 4621 A local anesthetic.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.719099508158039 0.218349583773353 no 2673 0.236039805177354 842 115019
SGTC_269 exalamide 29 µM -0.719156618875478 0.21833173105125 no 2674 0.236022212536596 840 3316 A derivative of salicylamide.
SGTC_1226 3909-7979 35.4 µM -0.721396117202558 0.217632330604619 no 2675 0.235332917422469 846 6615510
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.721661080851746 0.217549667467061 no 2676 0.235251437849575 828 66535 A nucleotide analog.
SGTC_521 r062-0005 13.8 µM -0.72167089912217 0.217546604719503 no 2677 0.235248418910273 830 2832033
SGTC_1863 st057641 20.1 µM -0.721901029648796 0.21747482408079 no 2678 0.235177664092385 864 3921635
SGTC_2001 4023502 57.655 µM -0.722271363280584 0.217359341018723 no 2679 0.235063827783064 845 108941 YCR052W RSC6
SGTC_1158 4092-0494 91.8 µM -0.722540849384604 0.217275328029118 no 2680 0.234981009984147 824 1148199
SGTC_2204 7233102 200 µM -0.72451611524061 0.216660106578701 no 2681 0.234374468614888 838 2172480
SGTC_2303 7774051 200 µM -0.725534451862973 0.216343326833678 no 2682 0.234062108596346 864 2953184
SGTC_2261 9010538 184.68 µM -0.726230037466586 0.216127101271359 no 2683 0.233848880380804 865 6457250
SGTC_998 3996-0085 177 µM -0.726923834263756 0.215911556493682 no 2684 0.233636307785788 853 715391
SGTC_1118 chelidonine 707.474 nM -0.727786259765244 0.215643796852358 no 2685 0.233372218423317 843 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_339 3091-4833 71.4 µM -0.728121423153234 0.215539789717438 no 2686 0.233269630398861 846 3240077
SGTC_2485 5633444 17.78 µM -0.728139743681372 0.21553410537182 no 2687 0.233264023506718 831 5724239
SGTC_1248 0469-0687 58.6 µM -0.731700608376274 0.21443092072346 no 2688 0.232175662506072 838 4017482
SGTC_1462 k081-0014 26.5 µM -0.733061495723701 0.214010175586192 no 2689 0.231760461541238 813 3270634
SGTC_341 1486-1430 230 µM -0.733943306454021 0.213737803182216 no 2690 0.231491645843268 859 2054753 YPL210C SRP72
SGTC_2051 5263410 176 µM -0.734101289891452 0.213689026825773 no 2691 0.231443503731416 844 227584
SGTC_1815 st051655 58.2 µM -0.734684604585066 0.213508988394113 no 2692 0.231265799280231 847 5984156
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.737914059639426 0.212513826950698 no 2693 0.230283337342514 853 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2940 9060638 45.86 µM -0.73810138980481 0.212456184141787 no 2694 0.230226419639625 837 4027022
SGTC_2701 st077767 14.721 µM -0.738289937832601 0.212398175812788 no 2695 0.230169139852236 840 5721188
SGTC_3127 9126946 49.47 µM -0.738374732645935 0.212372091018304 no 2696 0.230143382283242 829 27243249
SGTC_2561 acetosyringone 100 µM -0.738721248382374 0.212265514429805 no 2697 0.230038140212707 868 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1257 0669-0121 16 µM -0.738798627062 0.212241719620369 no 2698 0.230014642816167 851 4307855
SGTC_2243 6634756 200 µM -0.741505452313943 0.211410322270274 no 2699 0.229193513554515 815 885676
SGTC_1768 st044301 37.178 µM -0.744181677145821 0.210590201983596 no 2700 0.228383285717948 889 3931349
SGTC_1800 st050079 29.0735 µM -0.746168389286522 0.209982589751235 no 2701 0.22778285044967 853 3645560
SGTC_1356 1502-0781 85.8 µM -0.747155855909249 0.209680968522821 no 2702 0.227484743598685 853 567702
SGTC_1653 st012112 65 µM -0.747601540759409 0.209544917775599 no 2703 0.227350267551943 855 720429
SGTC_3065 9113888 49.47 µM -0.749282889133538 0.209032133300315 no 2704 0.226843359365907 842 16648368
SGTC_640 3381-0960 37.1 µM -0.750688839519922 0.20860390873792 no 2705 0.226419970603473 865 1745025
SGTC_1429 4049-0205 9.46 µM -0.750848747597612 0.208555236690452 no 2706 0.226371844067359 836 22774478
SGTC_167 3672-0051 66.205 µM -0.751315432262834 0.208413227758625 no 2707 0.226231421936769 839 3237971
SGTC_3165 9101544 49.47 µM -0.751319454575717 0.208412004044435 no 2708 0.226230211865089 851 5002184
SGTC_2514 salinomycin 42.74 µM -0.75262328600958 0.208015560844543 no 2709 0.225838160278032 863 23682228 A polyether potassium ionophore.
SGTC_25 0118-0223 35.662 µM -0.753128919681301 0.207861937663611 no 2710 0.225686223775475 853 5333628
SGTC_2402 5553605 200 µM -0.754094969307464 0.207568615841765 no 2711 0.225396098975752 872 6758546
SGTC_529 4076-0302 30.3 µM -0.754547437468792 0.207431317005457 no 2712 0.225260286018726 863 5816522
SGTC_387 norethindrone acetate 66.7 µM -0.754985569461351 0.207298419570591 no 2713 0.225128820389357 864 541197
SGTC_2257 7960413 200 µM -0.755125667043199 0.207255934762152 no 2714 0.225086791964734 841 2974689 YIL048W NEO1
SGTC_1485 3909-9022 254 µM -0.756533804664572 0.206829200895831 no 2715 0.224664606202955 868 714516
SGTC_2414 st077232 92.9 µM -0.759679477175105 0.205877790609597 no 2716 0.223723099532445 838 729801
SGTC_999 SEC7.066 22.7 µM -0.759831352695129 0.205831921578047 no 2717 0.223677699693424 856 740511 YDR170C SEC7
SGTC_2480 5767542 37.17 µM -0.760581336408956 0.205605502451301 no 2718 0.223453585412343 847 2867358
SGTC_1300 1094-0077 113 µM -0.761623322650061 0.205291173658686 no 2719 0.223142425462649 857 5532636
SGTC_3077 9117319 49.47 µM -0.762588025367986 0.205000413102125 no 2720 0.222854564121196 871 17154678
SGTC_483 fpl-64176 144 µM -0.763145238867859 0.204832581032592 no 2721 0.222688391492176 871 3423
SGTC_3024 9090631 49.47 µM -0.763415150516777 0.204751313337146 no 2722 0.222607923634839 830 25236383
SGTC_1437 4092-1038 11.6 µM -0.763578717373888 0.204702074327577 no 2723 0.222559168062222 855 3977136
SGTC_2058 5236698 133 µM -0.765107100013672 0.204242321336093 no 2724 0.222103886182786 846 766665
SGTC_1183 1254-0324 198 µM -0.765687455952997 0.2040679055835 no 2725 0.2219311463565 843 5799357
SGTC_1142 3253-1408 9.78 µM -0.766062793064857 0.203955151890917 no 2726 0.221819470146934 857 256655
SGTC_3149 9097855 49.47 µM -0.766383899048137 0.203858719050629 no 2727 0.221723955119387 833 25236625 YMR079W SEC14
SGTC_1633 st005664 67.9 µM -0.767056216396253 0.203656900315867 no 2728 0.221524046150205 867 2063822
SGTC_887 0885-0007 9.62 µM -0.769574086246364 0.202902135970837 no 2729 0.220776290840672 871 5719458
SGTC_3122 9126309 49.47 µM -0.769668466320533 0.202873876837821 no 2730 0.220748290043384 884 17591206
SGTC_1659 st012954 42.1 µM -0.772134780722317 0.20213625060553 no 2731 0.22001730216481 862 24207262
SGTC_2801 7907800 81.82 µM -0.776085185673917 0.200958111235652 no 2732 0.218849345050867 862 6620925
SGTC_32 0928-0142 34.1 µM -0.777613417030378 0.200503450253566 no 2733 0.218398474451366 856 2244242
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.778647499831773 0.200196153124656 no 2734 0.218093695100618 866 4213774
SGTC_957 1187-1561 14.1 µM -0.78000784695028 0.199792331790843 no 2735 0.217693128195865 859 1538454
SGTC_848 0368-0089 85.6 µM -0.780019538776344 0.199788863177636 no 2736 0.217689687269398 859 762535
SGTC_2306 7482397 179.52 µM -0.780346398330417 0.199691908439139 no 2737 0.217593504588114 900 891448
SGTC_2560 caryophyllene 100 µM -0.781671486006954 0.199299144307847 no 2738 0.217203831613166 870 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2434 5670830 169.91 µM -0.784495926162223 0.198463516935989 no 2739 0.216374585706456 902 1549830
SGTC_66 0109-0187 42.4 µM -0.785194658148889 0.198257119543315 no 2740 0.21616972349018 854 759417
SGTC_1240 0356-0016 42.1 µM -0.787324638890645 0.197628747633786 no 2741 0.215545924931008 827 4305613
SGTC_865 0488-0499 301 µM -0.790039099299093 0.196829693597849 no 2742 0.214752467196855 848 9634651
SGTC_1365 1672-3266 55.4 µM -0.79037593330247 0.196730676598711 no 2743 0.214654126520171 854 6415873
SGTC_206 4546-0025 72.014 µM -0.790548964661607 0.196679823376527 no 2744 0.21460361917021 866 6620745 YIL048W NEO1
SGTC_389 tpck 16.7 µM -0.793215935715931 0.195897018819404 no 2745 0.213826012275573 872 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3244 9134489 49.47 µM -0.795728266962345 0.195161335784196 no 2746 0.213094996679776 886 16584271
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.797068612373992 0.194769531807908 no 2747 0.212705592108683 856 3256 An antibiotic and ribosome inhibitor.
SGTC_590 k048-0076 22.4 µM -0.798700175793575 0.194293246469366 no 2748 0.212232142416367 882 6832814
SGTC_3003 9075612 71.4286 µM -0.800660111117303 0.193722041555969 no 2749 0.211664220466679 886 6501993
SGTC_1966 st070145 16.1 µM -0.803021281854239 0.193035261646083 no 2750 0.210981216967661 878 3748532
SGTC_1914 st062367 72.6 µM -0.803969000687903 0.192760022854512 no 2751 0.210707439092831 886 978205
SGTC_3310 9130229 44.1445 µM -0.804452664183416 0.192619648592093 no 2752 0.21056779830284 893 7761258
SGTC_614 0462-0418 107 µM -0.804457512065225 0.192618241901605 no 2753 0.210566398922756 846 5188303
SGTC_1082 camptothecin 424.86 nM -0.80453560493497 0.192595582870906 no 2754 0.210543857539705 865 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_624 k048-0052 28 µM -0.805442529395976 0.192332553613475 no 2755 0.210282178969894 863 6835531
SGTC_1787 fluconazole 80 µM -0.805902178929265 0.192199328448531 no 2756 0.210149627395881 838 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_704 1310-0270 142 µM -0.805945396671243 0.192186805089939 no 2757 0.210137166991144 877 5718033
SGTC_2119 5528445 120.635 µM -0.80757326205837 0.191715456339101 no 2758 0.209668142035391 881 791935
SGTC_3354 9151612 71.43 µM -0.808190855222969 0.191536817506888 no 2759 0.209490360639619 855 27261949
SGTC_193 1273-0060 1.558 µM -0.808460490797599 0.191458857402174 no 2760 0.209412770714127 864 2847393 YHR072W ERG7
SGTC_3216 9129716 49.47 µM -0.812218595959947 0.190374296246769 no 2761 0.208333105440624 857 8056934
SGTC_1676 st018489 23.4 µM -0.8142608396153 0.18978650555505 no 2762 0.207747769287939 868 3696235
SGTC_1500 4488-1866 171 µM -0.817452694771075 0.188870076233228 no 2763 0.206834886242826 884 2900003
SGTC_1076 itraconazole 331 nM -0.818942080437508 0.188443385956675 no 2764 0.206409729901504 872 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2636 apigenin dimethyl ether 100 µM -0.819177587804438 0.188375970533294 no 2765 0.206342549997507 877 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_806 3966-4455 5.86 µM -0.81999567125144 0.188141904761923 no 2766 0.206109287438729 877 714982
SGTC_2134 5324836 1.464 µM -0.820526969721341 0.187989988592643 no 2767 0.205957880510728 889 699272
SGTC_411 enrofloxacin 100 µM -0.823264839256159 0.187208340450895 no 2768 0.205178701915748 859 71188 A bacterial gyrase inhibitor.
SGTC_2860 9025725 38.96 µM -0.824605180449592 0.186826413568937 no 2769 0.204797889664412 891 40546248
SGTC_231 b-estradiol 524 µM -0.825646085011007 0.186530143323518 no 2770 0.204502442304425 885 450 A steroid.
SGTC_1772 st048439 82.2 µM -0.826160821542194 0.186383742637469 no 2771 0.204356434746635 870 2927068 YDL195W SEC31
SGTC_1503 4585-0012 61.3 µM -0.826455696188532 0.186299906856611 no 2772 0.204272820063967 881 2922052
SGTC_2068 5226020 147 µM -0.826456239543366 0.186299752397022 no 2773 0.204272666009024 898 1810509
SGTC_3257 9139206 32.98 µM -0.827467862428804 0.18601231575933 no 2774 0.20398596511994 869 4910041
SGTC_2528 xanthyletin 44.79 µM -0.82827958611207 0.185781876248758 no 2775 0.203756090507447 894 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2019 4016004 108 µM -0.828449770540548 0.185733585207498 no 2776 0.203707915027893 888 45595336
SGTC_985 1493-0307 8.71 µM -0.829634427609607 0.185397646143633 no 2777 0.203372752803685 894 3278274
SGTC_1415 3966-0071 78.1 µM -0.831402839078026 0.184896871276291 no 2778 0.202873047879127 876 2893185
SGTC_2830 7992007 71.43 µM -0.832736182881278 0.184519854293178 no 2779 0.202496766650498 880 1952075
SGTC_1609 st001574 46.4 µM -0.832944161347075 0.184461089331126 no 2780 0.202438110957681 885 3960012
SGTC_1515 3460-0031 42.1 µM -0.833273197031446 0.184368143056255 no 2781 0.202345334526077 870 2876596
SGTC_372 0155-0182 15.9 µM -0.833394182076528 0.184333974427608 no 2782 0.202311227415252 821 771486
SGTC_2598 perillyl alcohol 100 µM -0.833544176398928 0.184291618461887 no 2783 0.202268947021545 900 10819 An apoptosis inducer.
SGTC_1496 4469-0713 57.4 µM -0.834249263958004 0.184092594317983 no 2784 0.202070267797855 895 746691
SGTC_1775 st081588 35.1725 µM -0.834852618455847 0.183922392510033 no 2785 0.20190034762765 879 1426443 YGL099W LSG1
SGTC_2362 9071156 126 µM -0.835109385886612 0.183849990065964 no 2786 0.201828061259517 900 653133
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.835614547387444 0.183707598097616 no 2787 0.201685891072839 874 551469
SGTC_520 3584-0023 682 µM -0.835796685885258 0.183656274820777 no 2788 0.201634645619322 879 1340790
SGTC_472 calcifediol 10 µM -0.836451561773253 0.183471816667162 no 2789 0.201450457905775 893 5283731 A vitamin D metabolite.
SGTC_3325 9138760 55.175 µM -0.836480195245917 0.183463754145073 no 2790 0.201442406873709 864 43844959
SGTC_2124 5246320 200 µM -0.836854219222793 0.183358457949417 no 2791 0.201337258192311 884 579342
SGTC_775 4577-0580 57.3 µM -0.840059332220945 0.182457691796156 no 2792 0.200437560254024 890 2006902
SGTC_469 w7 172 µM -0.840090236213851 0.182449020003473 no 2793 0.200428897055136 870 45115570 A P450 inhibitor.
SGTC_2228 7354201 200 µM -0.840838595707602 0.182239105737702 no 2794 0.200219180955025 910 753451
SGTC_1523 st012844 44.7 µM -0.840890941211235 0.182224428514202 no 2795 0.200204516878479 899 4274103
SGTC_1747 st037496 66.6 µM -0.842313577591745 0.181825816577841 no 2796 0.199806226514945 899 723305
SGTC_2061 5245884 80.95 µM -0.84321390868036 0.181573832659127 no 2797 0.199554410514073 896 573863
SGTC_1151 3909-8316 15.3 µM -0.845541275074372 0.180923464601405 no 2798 0.19890434883617 891 800431
SGTC_190 3970-0790 3.722 µM -0.846031697912177 0.180786605446285 no 2799 0.198767530774413 874 2832352
SGTC_1552 6-methylflavone 10.6 µM -0.849206841869006 0.179902109367627 no 2800 0.197883103413099 881 689013
SGTC_1706 st031321 9.9705 µM -0.849453176166708 0.179833602107069 no 2801 0.197814587208475 882 6103185
SGTC_1053 3366-3204 134 µM -0.855485694002979 0.178161034328935 no 2802 0.196141160477624 904 3632071 YPR165W RHO1
SGTC_1804 st050076 49.1 µM -0.859328732493699 0.177100648694576 no 2803 0.195079588224892 897 3895976
SGTC_911 3456-4043 236 µM -0.860118082401883 0.176883342862509 no 2804 0.194861977239722 880 914281
SGTC_90 0870-0863 4.608 µM -0.860708443857656 0.176720928196223 no 2805 0.19469932068404 907 1738164
SGTC_1805 st050013 60.3 µM -0.860871622340375 0.176676052710707 no 2806 0.194654376277594 880 4037144
SGTC_1137 ixabepilone 100 µM -0.861167082241724 0.176594817033694 no 2807 0.194573013537212 878 154225 A novel microtubule stabilizer.
SGTC_673 1082-0474 110 µM -0.862078633726304 0.176344337994937 no 2808 0.194322124048275 898 3098046
SGTC_816 0325-0417 81.3 µM -0.862942698872735 0.176107115041213 no 2809 0.194084486334949 877 68101
SGTC_688 0527-0193 473 µM -0.864119309103053 0.175784410051172 no 2810 0.193761176387768 924 4007154
SGTC_1327 1436-0082 2.18 µM -0.864122868066232 0.175783434514706 no 2811 0.193760198951219 905 15992205
SGTC_1180 1193-0155 285 µM -0.864353149981313 0.175720319936276 no 2812 0.193696960528287 907 2921347
SGTC_2949 9072542 2.23 µM -0.866817671093747 0.175045754867619 no 2813 0.193020959129945 916 16457352
SGTC_2448 5185112 27.17 µM -0.867340316633585 0.174902912764766 no 2814 0.192877786377047 880 5718189
SGTC_119 0121-0043 24.815 µM -0.86991587601773 0.174200078094366 no 2815 0.192173189354511 910 1092378
SGTC_616 4092-0450 108 µM -0.873409580359932 0.173249567384146 no 2816 0.191219935485801 916 787165
SGTC_163 TUB2.036 7.546 µM -0.873639115441741 0.173187235011018 no 2817 0.19115740870531 886 15992207 YJR013W GPI14
SGTC_890 0929-0006 47.2 µM -0.874754838761683 0.172884453499708 no 2818 0.190853657346473 905 1378169
SGTC_2405 ticlatone 3.52 µM -0.876092551531053 0.172521874146567 no 2819 0.190489860836644 929 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.879272784865109 0.171661838620498 no 2820 0.189626694180028 897 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2141 5621638 7.665 µM -0.881002834371498 0.171195130873994 no 2821 0.189158142942748 896 2856238
SGTC_1497 4476-2978 41.3 µM -0.881083979287767 0.171173260710345 no 2822 0.189136183892418 881 1528379
SGTC_1246 0422-0085 105 µM -0.882389222550097 0.170821717301634 no 2823 0.188783180931559 898 264295
SGTC_1092 toremifene 6.32 µM -0.88350468102171 0.170521655357724 no 2824 0.188481827254979 918 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_445 e6 berbamine 66 µM -0.884034057431745 0.170379369554304 no 2825 0.188338914113392 894 6610268 A calcium/calmodulin antagonist.
SGTC_987 1497-1013 404 µM -0.885982798903903 0.169856242224089 no 2826 0.187813398176038 889 1676435
SGTC_265 mycophenolic acid 32.932 µM -0.885983000354572 0.169856188199223 no 2827 0.187813343897812 906 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2726 cimetidine 79.27 µM -0.886140750862267 0.169813886186768 no 2828 0.187770843078119 896 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_690 glyoxal 20.3 µM -0.886298539508437 0.169771580705856 no 2829 0.187728337926129 896 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2488 5268135 45.7 µM -0.888003258050943 0.169314951364547 no 2830 0.18726949938736 902 1270356 YLR208W SEC13
SGTC_2571 chrysanthemic acid 100 µM -0.891785694263868 0.168304598478883 no 2831 0.186253905495812 928 2743 An insecticide.
SGTC_3299 9121982 43.1275 µM -0.891826636748197 0.16829368330507 no 2832 0.186242931037415 900 17594604 YPL160W CDC60
SGTC_1976 st070609 63.5 µM -0.89294884756626 0.167994681725635 no 2833 0.185942283237935 884 682556
SGTC_2980 9014342 25.29 µM -0.896444604009745 0.167065466114782 no 2834 0.185007676988689 881 2996599
SGTC_2838 9002687 71.43 µM -0.896697293722489 0.166998426723711 no 2835 0.184940232556143 910 6457060
SGTC_2128 5255449 168.493 µM -0.897527547896505 0.166778279794149 no 2836 0.184718740217345 887 736008
SGTC_1840 st055363 71 µM -0.897759184320707 0.166716893413299 no 2837 0.184656974488243 926 676033
SGTC_1913 st060213 96.1 µM -0.899143103173836 0.166350442425615 no 2838 0.184288220868121 912 688959
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.902220977052985 0.165537311546374 no 2839 0.183469746842475 935 4620898
SGTC_1587 estradiol valerate 56.1 µM -0.902517277643338 0.165459168989559 no 2840 0.183391073773988 916 13791 A steroid.
SGTC_2979 9012552 45.46 µM -0.903153351616913 0.165291499524067 no 2841 0.183222255889344 919 17100905
SGTC_944 3370-0224 231 µM -0.905134323251144 0.164770018968659 no 2842 0.182697115242613 919 4580514
SGTC_2346 9031566 143.75 µM -0.906233980533654 0.164481000383635 no 2843 0.182406010420682 904 4771086
SGTC_1245 0418-0076 17.2 µM -0.907089053342228 0.164256492202828 no 2844 0.182179853176113 924 6790114
SGTC_1711 st032263 62.8 µM -0.907903742935489 0.164042771998135 no 2845 0.181964539961723 916 3958979
SGTC_2848 9016370 25.97 µM -0.911120853146759 0.163200580468621 no 2846 0.181115850060484 867 7894410
SGTC_3172 9105863 49.47 µM -0.911147472997475 0.163193623529348 no 2847 0.181108837969515 912 2348785
SGTC_692 k241-0027 77.8 µM -0.911620145382981 0.163070125511481 no 2848 0.180984356886733 882 3600480
SGTC_1215 3852-0577 11.2 µM -0.912269082723221 0.162900672642493 no 2849 0.180813542734203 893 2884876
SGTC_719 2810-4230 27.3 µM -0.912508187527935 0.162838265604399 no 2850 0.180750630734179 908 721079
SGTC_2945 9067681 61.76 µM -0.912697691065782 0.162788815684188 no 2851 0.180700779308376 932 16456930
SGTC_720 r052-1644 49.9 µM -0.913509179644942 0.162577172605331 no 2852 0.180487403955793 911 1422863 YOR257W CDC31
SGTC_2267 7931562 200 µM -0.914138366624917 0.162413198595152 no 2853 0.180322072381625 906 934880
SGTC_2132 5317594 122.667 µM -0.914523015900371 0.162313007208949 no 2854 0.180221044846414 916 794577
SGTC_1374 2889-5571 141 µM -0.914861983314852 0.162224748147374 no 2855 0.180132045034012 886 2853281
SGTC_1942 st076330 65.2 µM -0.915199151266063 0.162136988627122 no 2856 0.180043545067445 909 24208414
SGTC_1015 4130-4525 82 µM -0.91876142770653 0.161211673263893 no 2857 0.179110185956439 910 1363237
SGTC_2148 5546263 113.568 µM -0.920831749675765 0.16067548503122 no 2858 0.178569137971385 926 792097
SGTC_2419 paclitaxel 166.5 µM -0.921431987459274 0.16052024877123 no 2859 0.178412467390918 913 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_597 k018-0003 82.8 µM -0.922863852543112 0.16015032900807 no 2860 0.178039080102131 925 6786234
SGTC_906 1165-0455 526 µM -0.92432825638462 0.159772579831114 no 2861 0.177657717695222 912 3252859
SGTC_2951 9072950 58.06 µM -0.926417970583543 0.159234539471654 no 2862 0.177114404288479 901 16488155
SGTC_100 0086-0128 49.5915 µM -0.927453705123783 0.158968308422731 no 2863 0.176845508852164 905 93297
SGTC_2699 st077704 54.6 µM -0.928314886883364 0.158747167619148 no 2864 0.176622127052378 906 645852
SGTC_1221 2958-7315 257 µM -0.930312015025845 0.1582351063667 no 2865 0.176104779344302 914 4562705
SGTC_545 4218-0007 221 µM -0.932717537064379 0.157619774035069 no 2866 0.175482913883283 928 2840508
SGTC_2831 7999036 19.48 µM -0.933732362082426 0.157360654036629 no 2867 0.175220983556888 938 2988270
SGTC_1012 4112-3522 18 µM -0.934949268524149 0.157050305062797 no 2868 0.174907222323551 898 3112398
SGTC_3226 9131256 49.47 µM -0.935602189648261 0.156883955941294 no 2869 0.174739023382489 878 17178073
SGTC_2191 5911152 200 µM -0.935877159867283 0.156813934627543 no 2870 0.174668219071092 901 2875902
SGTC_1623 st003709 20.3 µM -0.941155616689101 0.155473759875691 no 2871 0.173312558815301 908 16192618
SGTC_1445 4239-0156 97.7 µM -0.942113599753378 0.155231345166985 no 2872 0.173067241216086 942 4008346
SGTC_3030 9087619 49.47 µM -0.943151442605039 0.154969003886717 no 2873 0.172801723096933 894 25236973
SGTC_1891 st059073 26.2 µM -0.944055522638818 0.154740713336902 no 2874 0.172570638102003 904 688754
SGTC_1944 st076371 56.9 µM -0.947592354903876 0.153849758664003 no 2875 0.171668509832677 906 24208455
SGTC_831 k061-1017 217 µM -0.948230277206291 0.153689423369223 no 2876 0.171506118342429 941 1240153
SGTC_2506 ethyl hematommate 54.16 µM -0.951457359831469 0.152880024758888 no 2877 0.17068612716528 931 3940691 An allergen.
SGTC_3274 9138298 49.47 µM -0.952468569168383 0.15262698162624 no 2878 0.170429699408039 941 17015756
SGTC_2429 5902844 64.44 µM -0.953997129528981 0.152245005290749 no 2879 0.170042547688636 915 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1109 tnp00067 928.257 nM -0.954000210876622 0.152244235925491 no 2880 0.170041767818775 923 676295
SGTC_340 k038-0059 454 µM -0.954454863313942 0.152130744471673 no 2881 0.169926723248283 913 23733424
SGTC_2922 7999257 32.47 µM -0.956127421992562 0.151713719885219 no 2882 0.169503931072227 935 2988377
SGTC_1199 1638-0010 4.46 µM -0.956728319968183 0.151564081684162 no 2883 0.169352200030414 913 3111136
SGTC_3317 9138495 8.753 µM -0.958305307936593 0.151171840120743 no 2884 0.168954414022873 913 17020139
SGTC_1534 6-azauridine 81.6 µM -0.958562861928923 0.151107843361216 no 2885 0.168889504594012 910 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2824 7998404 51.95 µM -0.959100339355568 0.150974349573812 no 2886 0.168754099740061 931 837851
SGTC_3053 9095903 49.47 µM -0.96111054366388 0.150475769098068 no 2887 0.168248294413049 956 17174018
SGTC_1034 k072-0165 12.7 µM -0.962350779834066 0.150168707539543 no 2888 0.167936714568117 942 5835461
SGTC_2680 butyl paraben 22.24 µM -0.963484244732815 0.149888446271916 no 2889 0.167652283510064 948 7184 An antifungal and steroid mimetic.
SGTC_2839 9003951 25.97 µM -0.970194957184857 0.148236300974472 no 2890 0.1659746619363 902 2990634
SGTC_789 1309-1135 70.6 µM -0.970230039462274 0.148227696022602 no 2891 0.165965920264902 898 3092424
SGTC_1967 st070177 51.4 µM -0.972308715905818 0.147718436494057 no 2892 0.16544849453408 944 5729214
SGTC_2377 9073351 62.6 µM -0.976122168990483 0.146787220062151 no 2893 0.164501963317765 950 7337946 YHR072W ERG7
SGTC_525 k781-2675 26.7 µM -0.976600549685391 0.146670681731416 no 2894 0.16438347343698 888 3651118 YDL195W SEC31
SGTC_1363 1636-0063 10.4 µM -0.978350609622251 0.146244878722321 no 2895 0.16395047352589 903 6072185
SGTC_1590 st077108 57.8 µM -0.978378521125221 0.146238094372058 no 2896 0.16394357366154 908 5489485
SGTC_3097 9117246 49.47 µM -0.979185398888201 0.146042060821813 no 2897 0.163744190862756 911 16423892
SGTC_3335 9143315 29.6265 µM -0.980339411417492 0.145761996709105 no 2898 0.163459303300627 898 4899691
SGTC_2622 2-methoxyxanthone 59.94 µM -0.981336298166319 0.145520355833084 no 2899 0.163213464217544 927 71034 A hepatoprotective.
SGTC_362 0310-0100 9.03 µM -0.982199665354559 0.145311297305199 no 2900 0.163000746214301 919 790235
SGTC_2856 9022925 19.48 µM -0.983988134181619 0.144878874753573 no 2901 0.16256067358348 938 4944862
SGTC_3259 9138485 49.47 µM -0.984258628787139 0.144813549084546 no 2902 0.162494182742592 918 17646153
SGTC_21 0849-0113 22.993 µM -0.984276416463668 0.144809253975489 no 2903 0.162489810937115 914 1560156
SGTC_2279 7948423 32.93 µM -0.984656968191128 0.144717384436772 no 2904 0.162396298331507 915 1247112
SGTC_6 0844-0013 19.835 µM -0.985693040347406 0.144467463728135 no 2905 0.162141882861277 944 1584900
SGTC_1405 3909-7894 12 µM -0.988526698361774 0.14378541659547 no 2906 0.161447382799123 897 7104060
SGTC_476 mead acid 10 µM -0.98984791618298 0.143468149990974 no 2907 0.161124230126285 940 5312531 An omega 9 fatty acid.
SGTC_2694 st077685 81.9 µM -0.991323146091356 0.143114459024166 no 2908 0.160763907164786 929 2838096
SGTC_2618 avocadyne 43.43 µM -0.991751756291159 0.143011808919902 no 2909 0.160659318404792 935 3015189
SGTC_348 k064-0012 10.7 µM -0.99193800608602 0.142967218489624 no 2910 0.160613883888431 921 5066323
SGTC_1097 itavastatin 7.23 µM -0.992105407610806 0.142927148578544 no 2911 0.160573054456182 916 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3104 9120930 49.47 µM -0.995186112867084 0.142191093379865 no 2912 0.159822877333344 927 17014836
SGTC_146 3448-8650 53.125 µM -0.995529835241899 0.142109129125051 no 2913 0.159739320503268 957 2891488 YIL048W NEO1
SGTC_3169 9102970 49.47 µM -0.996414962524911 0.141898208340913 no 2914 0.159524283007005 950 17027839
SGTC_993 3909-8757 62.7 µM -0.996529138708326 0.141871016250382 no 2915 0.159496558245892 923 4288324 YLR208W SEC13
SGTC_349 k015-0014 24 µM -0.998674498568233 0.141360735405965 no 2916 0.158976199038912 926 2196908
SGTC_402 epigallocatechin gallate 10 µM -1.00032892875633 0.140968074358196 no 2917 0.158575675891878 920 65064 An antioxidant.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.00146208031677 0.140699560411422 no 2918 0.158301731925661 946 689007
SGTC_557 1315-0110 16.2 µM -1.00336916615964 0.140248437478051 no 2919 0.157841387690984 924 6833801
SGTC_2349 9023730 187.07 µM -1.00405364083998 0.14008676419354 no 2920 0.15767637954699 945 4126287
SGTC_3201 9113999 49.47 µM -1.00455548027269 0.139968309932863 no 2921 0.157555471797358 944 16649224
SGTC_1359 1582-0056 520 nM -1.00820356141607 0.139109262325597 no 2922 0.156678374264512 950 3661189
SGTC_46 0329-0187a 2.197 µM -1.0114241893906 0.138353859555009 no 2923 0.155906724258982 920 46494817
SGTC_368 fentichlor 4.58 µM -1.01222964902812 0.138165375767835 no 2924 0.155714131538427 972 7329 A pesticide.
SGTC_2895 9054447 58.44 µM -1.01331805161727 0.137910959397073 no 2925 0.155454133933833 955 2697450
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.01357519297923 0.137850898768848 no 2926 0.155392749859921 930 5355888
SGTC_2944 9067346 25.62 µM -1.0146498109433 0.137600092885615 no 2927 0.15513639314814 935 6473075
SGTC_1263 0774-1208 64.8 µM -1.01505442499933 0.137505740475095 no 2928 0.155039942378306 939 906585
SGTC_3048 9093155 49.47 µM -1.0158521096148 0.137319856891669 no 2929 0.154849908550158 883 25236002
SGTC_1279 0874-0590 65.2 µM -1.02068751852325 0.136196740399645 no 2930 0.153701254927594 935 3523074
SGTC_1725 st036284 20.55 µM -1.02120623052183 0.136076634003875 no 2931 0.15357837053447 928 707914
SGTC_1442 4112-3290 3 µM -1.02283140887414 0.135700797753482 no 2932 0.153193782361262 956 704353
SGTC_2587 piperic acid 92.2 µM -1.02401127831941 0.1354283888405 no 2933 0.152914973930464 928 5370536
SGTC_591 4299-0174 154 µM -1.02581235204916 0.1350132790342 no 2934 0.152490021326878 972 5509088
SGTC_708 3448-5400 146 µM -1.02771637075004 0.134575392373316 no 2935 0.152041632404884 942 3462195
SGTC_2595 hexamethylquercetagetin 100 µM -1.02916846223241 0.13424209593998 no 2936 0.151700259730378 955 386331
SGTC_1135 dihydrocapsaicin 536.708 nM -1.03687129251597 0.132483560031445 no 2937 0.149897922237054 948 107982 A Capsaicinoid.
SGTC_499 genistein 192 µM -1.03826621684715 0.132166807793683 no 2938 0.149573066089134 961 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_37 0566-0070 1.56 µM -1.03897099542253 0.13200696900642 no 2939 0.149409112918862 928 1626686
SGTC_463 ikarugamyin 104 µM -1.04140849154036 0.131455190246114 no 2940 0.148843001593909 974 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1669 st015249 58.4 µM -1.04230389152771 0.131252897980198 no 2941 0.148635404357437 960 722793
SGTC_1175 0741-0056 27.6 µM -1.04280242527782 0.131140360505836 no 2942 0.148519903931921 939 765927
SGTC_562 3772-2733 112 µM -1.04493175012833 0.130660443663771 no 2943 0.14802725713934 937 2876874 YIL048W NEO1
SGTC_1222 0366-0074 1.18 µM -1.04696146378447 0.130204109283141 no 2944 0.147558675971736 952 286520
SGTC_2947 9072639 7.68 µM -1.04983776511766 0.1295593297148 no 2945 0.146896354454488 977 16488146
SGTC_1627 st003713 25.6 µM -1.0547457438132 0.128464223954806 no 2946 0.145770812347664 950 16195070 YER133W GLC7
SGTC_227 fluconazole 33.516 µM -1.05629771738932 0.128119276722256 no 2947 0.145416109251302 944 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_627 1391-0720 175 µM -1.05854161839502 0.127621677596014 no 2948 0.144904293619977 965 997839
SGTC_1191 1487-1166 10.6 µM -1.05971190103365 0.127362693851466 no 2949 0.144637843436519 986 3955771
SGTC_3209 9113616 49.47 µM -1.06050413148045 0.127187580743576 no 2950 0.144457655700612 950 16649353
SGTC_1501 4491-0275 38.4 µM -1.06109301908575 0.127057522735415 no 2951 0.144323815038666 935 5104718
SGTC_2696 st077691 74.316 µM -1.06191859054982 0.126875348091588 no 2952 0.144136322319446 960 757133
SGTC_751 0833-0568 350 µM -1.06298163879006 0.126641038586213 no 2953 0.143895139047663 947 6954252
SGTC_1938 st074717 56.4 µM -1.06339526351367 0.126549951869225 no 2954 0.143801369915125 893 17250979
SGTC_314 1671-0008 2.74 µM -1.06545406923525 0.12609724915423 no 2955 0.143335250012896 946 3913060
SGTC_2174 5790901 200 µM -1.06619151179355 0.125935370750817 no 2956 0.143168539215744 948 786020
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.06701676496601 0.125754388647993 no 2957 0.142982132768167 901 279621
SGTC_3246 9135460 32.98 µM -1.06860685525307 0.125406185739899 no 2958 0.142623429129479 931 41446951
SGTC_2964 9083345 53.42 µM -1.06884646272065 0.125353774155083 no 2959 0.142569429609139 919 17741579
SGTC_254 nsc-64875 3.808 µM -1.06886368671593 0.125350007178517 no 2960 0.14256554842861 947 56993
SGTC_1287 0971-0001 34.6 µM -1.07192921588592 0.12468081841535 no 2961 0.141875913254136 922 4665869
SGTC_3342 9147791 14.508 µM -1.07239222351373 0.124579963755372 no 2962 0.141771949669262 939 1838168
SGTC_2565 isoliquiritigenin 100 µM -1.07311310319227 0.124423051647177 no 2963 0.141610186301639 920 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1186 1319-0216 26 µM -1.07474451633228 0.124068456373561 no 2964 0.141244563642777 944 4565136
SGTC_2176 5809774 33.9695 µM -1.07566155913949 0.123869443567447 no 2965 0.141039322654958 900 2870539
SGTC_409 arachidonic acid 100 µM -1.07616166088767 0.123761007773685 no 2966 0.140927481439503 949 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1292 0kpi-0043 232 µM -1.07640156013037 0.12370901462191 no 2967 0.140873852468399 948 3333905
SGTC_1956 st077085 54 µM -1.08194059382897 0.122512795937835 no 2968 0.139639462823273 953 24208685
SGTC_821 1114-0266 29.2 µM -1.08327989646794 0.122224780526588 no 2969 0.139342102876497 939 3123235
SGTC_1054 3429-0080 167 µM -1.0849776036394 0.121860374279338 no 2970 0.138965787405006 971 1162877
SGTC_1196 1588-0294 184 µM -1.08554155854814 0.121739492598336 no 2971 0.138840933837675 950 6144269
SGTC_2930 9013230 14.89 µM -1.08638794728041 0.121558230412462 no 2972 0.13865369584452 912 2995857
SGTC_68 0986-0284 82.829 µM -1.08822518173863 0.121165422220044 no 2973 0.138247855266335 922 423278 YIL048W NEO1
SGTC_662 k832-1615 104 µM -1.08832439986332 0.121144234420988 no 2974 0.138225961298382 958 5878478
SGTC_2641 levomentholum 100 µM -1.08910045817841 0.12097859888955 no 2975 0.138054793943648 945 16666
SGTC_3121 9125696 49.47 µM -1.08942023609236 0.120910394488195 no 2976 0.137984305826 979 1235365
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.08983994434731 0.120820917335876 no 2977 0.137891827487358 948 1377
SGTC_2177 5811945 192 µM -1.09233181726558 0.120290637334454 no 2978 0.137343640087433 934 5343475
SGTC_927 2425-1185 123 µM -1.09520533782071 0.119681179330543 no 2979 0.136713343857576 970 730375
SGTC_252 miconazole 1.30953 nM -1.09631108536601 0.119447237538135 no 2980 0.136471329913489 932 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2508 celastrol 40.54 µM -1.09668319991324 0.119368582278509 no 2981 0.136389951487118 904 122724 Celastrol is a natural product and antioxidant.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.09684738542032 0.119333889389828 no 2982 0.136354056008537 933 688667
SGTC_882 0843-0131 351 µM -1.09741990164065 0.119212970667832 no 2983 0.136228938743083 942 5425421
SGTC_1868 st057644 42.7 µM -1.0982769395199 0.119032121008303 no 2984 0.136041789196193 970 688665
SGTC_3066 9117245 49.47 µM -1.09905024314313 0.118869107035229 no 2985 0.13587307563285 936 17176980
SGTC_158 k038-0087 26.446 µM -1.09908345801989 0.118862108805197 no 2986 0.135865832271551 906 X158
SGTC_2453 5731132 22.18 µM -1.09964581049466 0.11874366775398 no 2987 0.135743236932821 974 1362040
SGTC_3296 9122258 64.045 µM -1.10012867103652 0.118642035613396 no 2988 0.135638031664685 956 4730474
SGTC_2849 9019321 12.99 µM -1.10017208991227 0.118632899852285 no 2989 0.135628574332735 946 16489627
SGTC_1878 temozolomide 1 mM -1.10061440736811 0.118539860206189 no 2990 0.135532256193013 927 5394 DNA alkylating agent.
SGTC_192 3455-0609 60.9 µM -1.10162349490523 0.118327795862321 no 2991 0.135312694824545 955 3769639
SGTC_611 3453-1652 23.7 µM -1.10481889264355 0.117658038302521 no 2992 0.13461903622723 956 1560575
SGTC_1408 3909-7976 48.8 µM -1.10544351339116 0.117527431505542 no 2993 0.134483728906084 949 24152374
SGTC_195 4234-0266 16.654 µM -1.10547752708094 0.117520322267385 no 2994 0.13447636343456 953 2303354
SGTC_3237 9133362 49.47 µM -1.10679063046855 0.117246101828189 no 2995 0.134192230048974 959 43845137
SGTC_3138 9097216 49.47 µM -1.10709035547978 0.117183572684875 no 2996 0.134127432468441 947 25237486
SGTC_1906 st060206 94.7 µM -1.10788568664716 0.117017763865146 no 2997 0.13395559394734 946 5133468
SGTC_373 0844-0104 25.9 µM -1.10810268864316 0.116972552668682 no 2998 0.133908734977037 942 5375804
SGTC_2822 7994718 71.43 µM -1.11234863177656 0.116090423072349 no 2999 0.132994140856805 985 1018011
SGTC_2465 5809242 33.21 µM -1.11802901524012 0.114917675748802 no 3000 0.131777300679832 1001 2731748
SGTC_825 1988-2224 89.6 µM -1.12181172936421 0.114141402034497 no 3001 0.130971249006392 958 1180859
SGTC_2187 6125751 200 µM -1.12509928383511 0.113469782733723 no 3002 0.130273482385634 969 874498
SGTC_2479 5617353 43.85 µM -1.1266903852567 0.11314574825696 no 3003 0.129936704480064 944 2731746
SGTC_2961 9083290 32.55 µM -1.12758046286785 0.112964768468772 no 3004 0.129748570756394 953 17741490
SGTC_884 0851-0618 334 µM -1.12826102579332 0.112826528831509 no 3005 0.129604849003813 956 9642473
SGTC_2865 9030313 51.95 µM -1.12958932805333 0.112557064857841 no 3006 0.129324654962176 971 42562754
SGTC_1065 prochlorperazine maleate 2.48 µM -1.13028709613721 0.112415697521758 no 3007 0.129177635043274 963 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1510 1123-0200 71.5 µM -1.1304494134846 0.112382830332799 no 3008 0.12914345135344 965 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.13098859809835 0.112273701622691 no 3009 0.129029945233119 960 6857784
SGTC_714 4296-0578 26.1 µM -1.13212262243343 0.112044427020824 no 3010 0.128791442593984 954 1589775
SGTC_3107 9121808 49.47 µM -1.13377719485072 0.111710509899961 no 3011 0.128444009661027 895 662681
SGTC_3333 9141820 12.094 µM -1.13465225867784 0.111534197192518 no 3012 0.128260523952511 944 1939433
SGTC_1565 sinapyl alcohol 95.1 µM -1.13661266873443 0.111139925877222 no 3013 0.127850120826935 952 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2135 5326629 150.42 µM -1.13874172636394 0.110712868308571 no 3014 0.127405446772067 967 5020077
SGTC_577 r071-0003 38.6 µM -1.14175308622469 0.110110843754189 no 3015 0.126778333900343 998 4568517 YMR134W ERG29
SGTC_1870 st057514 26.5 µM -1.14261538059175 0.109938889039665 no 3016 0.126599158400748 957 5393161
SGTC_2383 9036125 200 µM -1.14367895996438 0.109727060537841 no 3017 0.126378401076014 969 79580
SGTC_1474 0330-0125 5.35 µM -1.14578763943003 0.109307950607388 no 3018 0.125941515401941 1002 X1474
SGTC_582 0987-0078 156 µM -1.15069026183851 0.108337979441688 no 3019 0.124929842105437 975 1625765
SGTC_1686 st019653 115.5 µM -1.15084056034553 0.10830834143978 no 3020 0.124898917433348 989 97252
SGTC_2661 dactinomycin 12.96 µM -1.15184041386828 0.108111324587151 no 3021 0.124693328683647 964 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1122 capsaicin 818.572 nM -1.15218354067023 0.108043772419971 no 3022 0.124622829880406 969 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_536 3852-0578 10.6 µM -1.15221743498982 0.108037101216507 no 3023 0.124615867468718 975 2869208
SGTC_3331 9141060 1.957 µM -1.15380795108765 0.10772438346916 no 3024 0.124289456835852 951 4906567 YPR165W RHO1
SGTC_1197 1601-0112 267 µM -1.15547640753102 0.107397042921099 no 3025 0.123947694210927 966 7350313
SGTC_1867 st057372 64 µM -1.15560497377834 0.107371848826029 no 3026 0.123921386327668 963 688837
SGTC_1550 gossypolone 36.6 µM -1.15805931773848 0.10689170748862 no 3027 0.123419915205178 968 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.16092838673118 0.106332399916828 no 3028 0.122835511832183 930 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_860 0443-0016 25.1 µM -1.16157140739427 0.106207337386587 no 3029 0.122704800977146 962 5337942
SGTC_1667 st014849 34.6 µM -1.16427383500083 0.105682897774527 no 3030 0.12215652825892 964 5348460
SGTC_1419 3993-2473 62.6 µM -1.16571257811293 0.105404456751483 no 3031 0.121865336479898 976 704026
SGTC_2556 citropten 84.59 µM -1.16744534592778 0.105069817791499 no 3032 0.121515283828185 962 2775 A potential DNA crosslinker.
SGTC_3148 9097893 49.47 µM -1.16768578364992 0.105023444329696 no 3033 0.121466766651289 932 17174100
SGTC_509 pifithrin 175 µM -1.16906531093197 0.104757659870186 no 3034 0.12118865936637 997 4817 A p53 inhibitor.
SGTC_1486 3970-0793 4.53 µM -1.17191070693894 0.104210995280239 no 3035 0.120616453957699 978 2844330
SGTC_2790 5423970 71.43 µM -1.17343191738571 0.103919586200971 no 3036 0.120311322057355 959 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2507 purpurin 79.67 µM -1.17899110326452 0.102859673246136 no 3037 0.119200859246719 969 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3253 9135987 49.47 µM -1.18011462504668 0.102646420397872 no 3038 0.118977314302416 970 4182430
SGTC_1951 sophoraflavanone G 9.2 µM -1.18091759161961 0.102494208360571 no 3039 0.118817731101556 957 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_424 splitomicin 100 mM -1.18128294264587 0.102425005996356 no 3040 0.118745170568248 990 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3190 9110366 49.47 µM -1.18140220547355 0.102402423381013 no 3041 0.11872149115522 971 17123768
SGTC_970 1315-0089 19.5 µM -1.18182555128944 0.102322291381121 no 3042 0.11863746356771 958 6811083 YLR033W RSC58
SGTC_1665 st014639 11.4 µM -1.18210364339258 0.102269678206062 no 3043 0.118582289465602 962 981133 YIL048W NEO1
SGTC_2581 avocatin a 64 µM -1.18730494222418 0.101289250260709 no 3044 0.117553679687368 992 6710728 A skin care supplement.
SGTC_1977 st070720 65.3 µM -1.19337131363504 0.100154431451061 no 3045 0.11636199225588 958 682188
SGTC_2284 7945075 39.21 µM -1.19884479735322 0.0991385129604695 no 3046 0.115294149972295 963 1245402
SGTC_342 k048-0088 23.3 µM -1.19889128431922 0.0991299170361405 no 3047 0.11528511058722 968 6820570
SGTC_297 0986-0032 24 µM -1.20138631153552 0.0986693599025094 no 3048 0.11480069173466 970 2847425
SGTC_2935 9038016 29.96 µM -1.20213657333273 0.0985311758202719 no 3049 0.114655309205104 962 6463195
SGTC_1884 5633444 25 µM -1.20308269834722 0.0983571194833603 no 3050 0.114472159985861 962 5724239
SGTC_1482 3346-2049 8.48 µM -1.21009052697552 0.0970749122758709 no 3051 0.113122078875691 973 3826804
SGTC_619 1652-1634 108 µM -1.21092316333364 0.096923385833573 no 3052 0.112962427095268 989 5400454
SGTC_294 k038-0071 157 µM -1.21149904676278 0.0968186859306194 no 3053 0.11285209988788 985 24152826
SGTC_2664 lyso-paf C-16 73.48 µM -1.21325708254654 0.0964995756981499 no 3054 0.112515772964112 977 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1826 st055655 41.6 µM -1.21366493208839 0.0964256553589137 no 3055 0.112437850366292 987 676168
SGTC_377 3970-0964 33.1 µM -1.21697987647128 0.0958263840269386 no 3056 0.111805936222114 986 16481235
SGTC_813 k007-0158 173 µM -1.21808971081769 0.0956263630217888 no 3057 0.111594941725574 981 6523916
SGTC_2478 5763493 32.33 µM -1.22027064717434 0.0952341969286312 no 3058 0.111181146596625 966 1365576 YLR208W SEC13
SGTC_1735 st034310 56.75 µM -1.22476128833757 0.0944304421257757 no 3059 0.110332587266975 967 871153
SGTC_332 4112-0506 40.9 µM -1.22510793014043 0.0943686072320111 no 3060 0.110267278841886 985 2790355
SGTC_2367 9070478 135.38 µM -1.2251132855634 0.094367652151587 no 3061 0.110266270080575 969 572802
SGTC_2241 6772625 37.8075 µM -1.22522880283733 0.0943470526592194 no 3062 0.110244512559379 961 2285411
SGTC_3306 9127676 59.7925 µM -1.22550496851671 0.0942978191553853 no 3063 0.110192509609815 965 41905287
SGTC_3291 9121177 71.43 µM -1.2274927494825 0.0939440059472079 no 3064 0.109818722643167 979 17015612
SGTC_518 1021-0119 62.6 µM -1.23399437188355 0.0927935991231421 no 3065 0.108602500727635 978 1097762
SGTC_2456 5770359 74.46 µM -1.23588554476673 0.0924609360183204 no 3066 0.108250555456635 984 3118787
SGTC_484 loperamide 105 µM -1.23729096928509 0.0922142896664618 no 3067 0.107989539658154 968 3955 An opioid-receptor agonist.
SGTC_1443 4112-3303 14 µM -1.23948655452735 0.0918299485234294 no 3068 0.107582682514144 981 704433
SGTC_2258 7960471 200 µM -1.23955121194975 0.0918186481384263 no 3069 0.107570717811803 1002 2974708
SGTC_2816 7982706 58.44 µM -1.24245451205126 0.0913122900449296 no 3070 0.107034456834914 978 2981853
SGTC_2063 5246145 200 µM -1.24247287695474 0.0913090936655799 no 3071 0.107031070849845 985 711240
SGTC_370 0180-0345 38.7 µM -1.24274032188171 0.0912625547432489 no 3072 0.10698177008709 955 3989527
SGTC_221 trifluoperazine 10.304 µM -1.24447060030548 0.0909618885097691 no 3073 0.106663206571326 985 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1670 st016595 4.04 µM -1.24791436115396 0.0903656623912004 no 3074 0.106031210414201 997 597879
SGTC_717 1532-0246 73.2 µM -1.2496264476883 0.0900703272472264 no 3075 0.105718018585259 971 9561992
SGTC_2314 7727897 200 µM -1.25207061220279 0.0896499520816677 no 3076 0.105272067524593 946 900724
SGTC_1037 k284-1091 78.7 µM -1.25358071889781 0.0893909568767865 no 3077 0.104997221499241 977 3334711
SGTC_782 0083-0095 30.5 µM -1.25388732659087 0.0893384392825575 no 3078 0.104941481053056 985 3591729 An indicator and reagent.
SGTC_2350 9023895 38.85 µM -1.27120592622494 0.0864091405762777 no 3079 0.101827699423264 954 2997209
SGTC_2576 guaiol 23.12 µM -1.2769906177342 0.0854468832969001 no 3080 0.100802779828066 954 227829
SGTC_2612 dictamnine 15.46 µM -1.2778438023233 0.0853056417207384 no 3081 0.100652253193005 949 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2033 5192550 145 µM -1.27905218762981 0.0851058973580187 no 3082 0.100439339442298 965 182073
SGTC_82 0054-0107 293.755 µM -1.28052740768176 0.0848625209923321 no 3083 0.100179855970793 980 3104697
SGTC_712 r015-0009 80.6 µM -1.28067973480845 0.0848374203763462 no 3084 0.100153090328216 994 6813872 YLR060W FRS1
SGTC_347 4534-1311 26.2 µM -1.28159965727077 0.0846859529382644 no 3085 0.0999915602423626 990 2862016
SGTC_1200 1643-0193 18.4 µM -1.28354356895615 0.084366550450575 no 3086 0.099650852805837 987 5403974
SGTC_1983 st071813 46.9 µM -1.28715199558047 0.0837760506477594 no 3087 0.0990206576906511 996 11838595
SGTC_3168 9103419 49.47 µM -1.2874699856289 0.083724162490144 no 3088 0.0989652622792095 998 16649256
SGTC_962 1254-0300 21.5 µM -1.28908954414054 0.0834602649109321 no 3089 0.0986834790653877 973 7340576
SGTC_2071 5230951 39.92 µM -1.28954915435135 0.0833854881158213 no 3090 0.098603619629096 1007 1799272
SGTC_559 1550-0661 158 µM -1.29030017714408 0.0832634080185085 no 3091 0.0984732277120287 990 5830875
SGTC_3023 9089636 49.47 µM -1.2942225571642 0.0826280008397161 no 3092 0.0977942786726568 1026 17249241
SGTC_2390 9097792 176.6 µM -1.29537917318916 0.0824413329945862 no 3093 0.0975947295040517 983 4497149
SGTC_2107 5363541 170.161 µM -1.30038585296235 0.0816369586333619 no 3094 0.0967343780895437 985 244052
SGTC_1134 3477-0009 42.5 µM -1.3028573866983 0.0812420694762706 no 3095 0.0963117272475592 981 3973534
SGTC_287 k060-0039 29.6 µM -1.3035652454686 0.0811292372903957 no 3096 0.0961909284645518 981 5861974
SGTC_2624 nerol 100 µM -1.30470433216576 0.0809479159917387 no 3097 0.0959967728822199 997 637566 A natural product oil.
SGTC_1435 4092-0789 56.7 µM -1.30647412656802 0.0806668049187707 no 3098 0.0956956860799731 983 2248285
SGTC_2663 amphotericin b 100 µM -1.30822768511833 0.0803890004916717 no 3099 0.0953980472350565 992 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2851 9015922 71.43 µM -1.31560483259854 0.0792282021698424 no 3100 0.0941533553586285 973 2996893
SGTC_3118 9124250 49.47 µM -1.31593019539283 0.0791772998853517 no 3101 0.0940987364440045 969 1504786
SGTC_2120 5538279 151.968 µM -1.31654972521151 0.0790804442961518 no 3102 0.0939948001145022 1006 2058197
SGTC_1086 cerivastatin 2.18 µM -1.31704123576647 0.0790036667381792 no 3103 0.0939124014095798 973 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_777 1315-0167 517 µM -1.31887333541531 0.0787179767152231 no 3104 0.093605730933353 974 4221767
SGTC_295 k015-0027 31 µM -1.32108298263222 0.0783744557852447 no 3105 0.0932368482732834 999 3887424
SGTC_2286 7945697 125 µM -1.3235448139434 0.07799306926718 no 3106 0.0928271317883169 991 1245733
SGTC_413 propylparaben 100 µM -1.32469471455272 0.0778154100515073 no 3107 0.0926362134622827 989 7175 A pharmaceutical preservative.
SGTC_1194 1488-0194 225 µM -1.32556246623003 0.0776815462135542 no 3108 0.092492332804917 995 1391452
SGTC_2386 9075165 157.42 µM -1.32941019760494 0.0770900808504428 no 3109 0.0918563376427788 994 16452277
SGTC_2254 7938975 95.19 µM -1.32987826755371 0.0770183642084836 no 3110 0.0917791914422992 1003 2969277
SGTC_3068 9116768 49.47 µM -1.33210960170883 0.0766771809964072 no 3111 0.0914120878187343 994 41904888
SGTC_3130 9127414 49.47 µM -1.33588532350313 0.0761024722001944 no 3112 0.0907933793676135 1004 1494646
SGTC_1783 st039459 87.517 µM -1.33872001823734 0.0756731581112693 no 3113 0.0903309184518923 1020 729761
SGTC_790 1575-0012 79.1 µM -1.34001238538747 0.0754780426980934 no 3114 0.0901206591738152 985 378741 YLR208W SEC13
SGTC_2388 9080168 200 µM -1.34247899260986 0.0751067106093672 no 3115 0.0897203686626514 994 15943073
SGTC_1329 1447-1697 50.6 µM -1.343490598843 0.0749548231519355 no 3116 0.0895565840713619 1015 2840515
SGTC_1685 st024049 53.0905 µM -1.34503975263706 0.0747226799696454 no 3117 0.0893061986946864 991 1941139
SGTC_2378 9074213 121.43 µM -1.34747844545779 0.0743583501071054 no 3118 0.0889130954318149 990 657714
SGTC_3159 9100096 49.47 µM -1.34965003728218 0.0740350670154521 no 3119 0.0885641328823446 1011 25236875
SGTC_3021 9087658 49.47 µM -1.35153202989865 0.0737557658277868 no 3120 0.0882625334013455 990 25237042
SGTC_1481 3346-2004 36 µM -1.35287387955296 0.0735571180683961 no 3121 0.0880479626786087 1014 2770522
SGTC_1401 3807-4679 7.6 µM -1.35457256198493 0.0733062317494922 no 3122 0.0877768901340385 992 3291456
SGTC_746 1095-0025 46.6 µM -1.35822721749531 0.0727686784095267 no 3123 0.0871957983502785 991 6749286
SGTC_1285 0929-0069 65.5 µM -1.36050643320462 0.0724349660670765 no 3124 0.0868348592513714 1007 1206237
SGTC_1361 1608-0041 5.61 µM -1.37012031156858 0.0710402369580031 no 3125 0.0853246741765066 990 X1361
SGTC_248 streptozotocin 5.23457 mM -1.37521357844154 0.0703097394216942 no 3126 0.0845326199343492 1000 5300 DNA alkylating agent.
SGTC_438 sphingosine 6.67 µM -1.38061556412846 0.0695412907104651 no 3127 0.0836985976170645 1014 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2358 9037157 4 µM -1.38476960243966 0.0689547776340147 no 3128 0.0830614642764499 991 2388925
SGTC_1937 st074714 47.2 µM -1.38547074266075 0.0688561600994237 no 3129 0.0829542863372381 1004 17250970
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.38847541057496 0.0684347752976762 no 3130 0.0824961636673612 1035 390807
SGTC_3276 9139060 49.47 µM -1.38941544808071 0.0683033506676356 no 3131 0.0823532277252847 1016 4870619
SGTC_2118 5526350 200 µM -1.39214549676265 0.0679227725188749 no 3132 0.0819391716898627 1007 743594
SGTC_760 0568-0725 82.9 µM -1.39261979414913 0.0678568211130792 no 3133 0.0818673970446815 1011 3916171
SGTC_2461 5755302 26.15 µM -1.40244166910332 0.0665021704436847 no 3134 0.0803916988041577 1033 2788904
SGTC_3347 9188721 44.724 µM -1.40406183142021 0.0662807402879595 no 3135 0.0801502190938441 1030 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2760 etidronate 98.04 µM -1.40691495232698 0.0658921883754236 no 3136 0.0797263046222616 999 3305 A chelator and antioxidant.
SGTC_1305 1181-0477 144 µM -1.40988183930855 0.0654900178487621 no 3137 0.0792872879743883 1024 6252086
SGTC_2808 7946468 45.46 µM -1.41781795794431 0.0644236080372508 no 3138 0.0781219599197505 1015 2970879
SGTC_1492 4158-0558 28.5 µM -1.41827935665449 0.0643620254206226 no 3139 0.0780546105847646 973 3967268
SGTC_2155 5570423 76 µM -1.42007013129886 0.0641234449921919 no 3140 0.0777936324333505 1019 797402
SGTC_1836 st055642 81 µM -1.42115132694207 0.06397973320159 no 3141 0.0776363855808719 1001 8571
SGTC_2133 5320837 200 µM -1.4224681428581 0.0638050413346157 no 3142 0.0774451966709901 1025 2841355
SGTC_1193 1488-0126 41.5 µM -1.42253868977521 0.0637956928973581 no 3143 0.0774349640427521 1002 1384710
SGTC_855 0428-0020 25 µM -1.42788824509585 0.0630899018100359 no 3144 0.076662013781559 1006 6812414
SGTC_752 1896-0090 130 µM -1.42982873793231 0.0628353921282293 no 3145 0.0763830894324117 1016 772567
SGTC_2025 5147754 141 µM -1.43161096784512 0.0626023452149406 no 3146 0.076127594499889 959 315777 YLR208W SEC13
SGTC_847 0342-0274 5.54 µM -1.43206592604812 0.0625429623146882 no 3147 0.0760624774537767 1017 18097
SGTC_1845 st056753 3.01 µM -1.43532486766061 0.0621188757039661 no 3148 0.0755972723222889 1002 5375839
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.43572222302661 0.062067321596642 no 3149 0.0755406995079426 1030 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2168 5727979 200 µM -1.44011103466865 0.0615001219181381 no 3150 0.0749179938296188 1018 695210
SGTC_2923 7992654 58.14 µM -1.44504312356128 0.0608675502225314 no 3151 0.0742228865897306 995 2985126
SGTC_3035 9091303 49.47 µM -1.44643093227356 0.0606904752064462 no 3152 0.0740281855809553 1037 25237002
SGTC_2771 fluoxetine 41.05 µM -1.45021284189673 0.0602099738786966 no 3153 0.0734995875225948 1010 3386 A selective serotonin reuptake inhibitor.
SGTC_2397 5161689 200 µM -1.45500478179928 0.0596054288338686 no 3154 0.0728339688470848 1020 2259942
SGTC_2956 9076196 2.52 µM -1.4562685752212 0.0594467855961524 no 3155 0.072659194516774 1034 16423868
SGTC_603 3794-0023 45.9 µM -1.45732819419115 0.0593140275155854 no 3156 0.0725129038643724 1027 3802260
SGTC_1828 st055811 49 µM -1.45770349977973 0.0592670618258845 no 3157 0.0724611434400367 1021 5877589
SGTC_300 r073-0011 5.04 µM -1.46714723033718 0.0580948465611932 no 3158 0.0711680041603768 1025 2735780
SGTC_678 1218-2179 85.9 µM -1.47039232921867 0.0576962767312594 no 3159 0.0707277638480399 1037 6820081 YOR116C RPO31
SGTC_1375 2910-0797 186 µM -1.47429903114563 0.0572193034872329 no 3160 0.0702005479657078 1014 742508
SGTC_669 0108-0021 26.2 µM -1.47618327209548 0.056990366617608 no 3161 0.0699473494690821 1022 17201
SGTC_1448 4255-0083 152 µM -1.47735648391641 0.0568481851090431 no 3162 0.0697900522216484 1034 5399660
SGTC_410 α-linolenic acid 100 µM -1.4812556859619 0.0563776472406895 no 3163 0.0692692261342791 1025 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_756 0508-1999 28.3 µM -1.48601474691532 0.0558075115685805 no 3164 0.0686376101929408 1017 6753853
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.48966848685731 0.0553728882256489 no 3165 0.0681557122441889 1035 364106
SGTC_2927 9011802 47.9 µM -1.49191191087768 0.0551073533973184 no 3166 0.0678611198833957 1018 43912568
SGTC_2334 9017922 200 µM -1.49260597915583 0.0550254065684153 no 3167 0.0677701786554517 1011 3163164
SGTC_2287 7945887 168.79 µM -1.4944255839681 0.0548110276453215 no 3168 0.067532209382033 1011 1245853
SGTC_3000 9075062 71.4286 µM -1.49463931859132 0.0547858896323239 no 3169 0.0675042994388383 981 17057871
SGTC_94 0334-0113 514.748 µM -1.49691327001571 0.05451900684717 no 3170 0.0672079134311256 1018 6795178
SGTC_880 0833-0487 87.2 µM -1.49897411356095 0.0542780246543474 no 3171 0.06694017387541 1023 76075
SGTC_1038 k292-0204 154 µM -1.50047862927458 0.054102628787116 no 3172 0.0667452326060395 1018 4454212
SGTC_375 3970-0961 9.27 µM -1.50068032425701 0.0540791494011657 no 3173 0.0667191322578683 999 2898222
SGTC_1457 k015-0032 57.3 µM -1.51341732741295 0.0526126962436231 no 3174 0.0650868431844679 1023 4302660
SGTC_1807 st050092 58.9 µM -1.51792286916274 0.0521015792983735 no 3175 0.0645169220112495 1028 5008496
SGTC_2529 gangaleoidin 93.61 µM -1.5198541924176 0.0518836976931347 no 3176 0.0642738127063285 1042 4565183
SGTC_2341 7987486 176.74 µM -1.5199266216883 0.0518755407162215 no 3177 0.0642647093920706 1020 1258686
SGTC_150 3970-0969 77.2 µM -1.52238571351128 0.0515992022245586 no 3178 0.0639562312039434 1014 6615640
SGTC_2903 5923464 63.88 µM -1.52695107823805 0.0510892774552669 no 3179 0.0633865884341912 1039 2876576
SGTC_1003 4049-0218 100 µM -1.52977994128546 0.0507753275803888 no 3180 0.0630356041295307 1028 295161
SGTC_1850 st056238 17 µM -1.54218312264259 0.0494169046250963 no 3181 0.0615145500820111 1007 5393177
SGTC_1163 k060-0048 49.9 µM -1.54306323847232 0.0493216255275936 no 3182 0.0614077165447819 1045 6809982
SGTC_834 0312-0008 75.7 µM -1.54379446740074 0.0492425761499953 no 3183 0.0613190660363439 1040 6385573 YIL048W NEO1
SGTC_338 4055-0136 114 µM -1.54528199877829 0.0490820790843018 no 3184 0.0611390338497788 1049 2900563
SGTC_18 0111-0177 500 nM -1.55085949939202 0.0484840125166363 no 3185 0.0604676790290078 1044 721752
SGTC_1386 3228-0095 33.8 µM -1.55388666409954 0.0481618624781957 no 3186 0.0601057266574167 1021 870181
SGTC_1992 st073643 23.3 µM -1.55680888224091 0.0478525077233419 no 3187 0.0597579338684923 1037 3161292
SGTC_666 0272-0154 136 µM -1.55836800874999 0.04768810591545 no 3188 0.0595730178548263 1046 6870312
SGTC_1981 st071826 47 µM -1.56154923752173 0.0473540649735537 no 3189 0.0591971079778926 1011 11838600
SGTC_3131 9127911 49.47 µM -1.56574080027633 0.0469168009049231 no 3190 0.0587046552028039 1019 45595681
SGTC_3281 9140613 49.47 µM -1.56877115093556 0.0466026959593984 no 3191 0.0583506364101209 1005 16013766
SGTC_2203 7227154 166.4 µM -1.56935035305851 0.0465428524506456 no 3192 0.0582831627587325 1037 896304
SGTC_1728 st035614 33.7865 µM -1.57272213941774 0.0461957010205026 no 3193 0.0578915855617419 1019 15945546
SGTC_1074 carmofur 3.8 µM -1.5760016852915 0.0458600443470267 no 3194 0.0575127074105562 1047 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1843 st055809 45.5 µM -1.58276935816483 0.045173578647254 no 3195 0.056737021587138 1036 16413835
SGTC_3054 9094397 49.47 µM -1.58474868993962 0.0449743791723484 no 3196 0.0565117222356216 1029 2598354
SGTC_448 monastrol 171 µM -1.59085550178852 0.0443642436604457 no 3197 0.0558210494278267 1039 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_510 ag-490 170 µM -1.59220097713919 0.044230717117406 no 3198 0.0556697768797353 1052 5328779
SGTC_754 3474-0146 171 µM -1.59292318399889 0.0441591781857634 no 3199 0.0555887123000498 1020 24762078
SGTC_820 1582-0060 59.9 µM -1.60320995962267 0.0431503026477609 no 3200 0.0544441536732151 1031 3848840
SGTC_1631 benzylvanillin 81.9 µM -1.60556746288468 0.0429217327007762 no 3201 0.0541844896281582 1007 75506
SGTC_2471 5466956 24.79 µM -1.60576694258891 0.042902437276199 no 3202 0.054162563250213 1024 724419
SGTC_1188 1403-0014 4.57 µM -1.61000193654947 0.0424944431297862 no 3203 0.0536987167648448 1015 9614867
SGTC_3351 9150312 21.596 µM -1.61026050859524 0.0424696346039693 no 3204 0.0536704983561259 1039 4904905
SGTC_2900 5328528 85.29 µM -1.61241670583074 0.0422632154772528 no 3205 0.0534356459794286 1031 795359
SGTC_2959 9079155 11 µM -1.61265525617713 0.0422404283047071 no 3206 0.0534097132537821 1038 16189457
SGTC_1234 0326-0494 15.5 µM -1.61295754336959 0.0422115670444233 no 3207 0.0533768660452473 1033 1547813
SGTC_949 1165-0505 146 µM -1.61503252359965 0.042013886061849 no 3208 0.0531518259301556 1028 6244267
SGTC_2370 9071495 200 µM -1.61527301259415 0.0419910234905116 no 3209 0.0531257926281169 1040 21791103
SGTC_1153 4055-0057 267 µM -1.62168439106997 0.041385217193685 no 3210 0.052435471312499 1024 882706
SGTC_1898 st060199 18.6 µM -1.62191221878429 0.0413638209398351 no 3211 0.0524110724550884 1010 688866
SGTC_2798 7813637 45.45 µM -1.62211596777591 0.0413446936146882 no 3212 0.0523892599068121 1030 956368
SGTC_905 2-aminofluorene 215 µM -1.62600149656363 0.0409813021531037 no 3213 0.051974668498155 1032 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3288 9119690 36.221 µM -1.62791871791771 0.0408029521743414 no 3214 0.051771060955761 1051 17595618 YKL019W RAM2
SGTC_2769 toremifene 3.73 µM -1.62871973141133 0.0407286244620337 no 3215 0.0516861818842733 1036 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1662 st014054 52 µM -1.62974683132873 0.0406334785257457 no 3216 0.0515775075672027 1049 2838777
SGTC_869 0564-0080 44.1 µM -1.63093724126368 0.0405234300729307 no 3217 0.0514517813080716 1033 6843321
SGTC_2846 9008642 19.48 µM -1.63426098051999 0.0402174446099766 no 3218 0.0511020315173844 1050 2992898
SGTC_20 0481-0013 4.944 µM -1.63481646932569 0.0401664894809078 no 3219 0.051043763606756 1028 182045
SGTC_1358 1509-0022 2.48 µM -1.63876948144462 0.0398053914807233 no 3220 0.0506306386661015 1039 3258434
SGTC_1920 st075728 45.7 µM -1.63900178437088 0.0397842535416925 no 3221 0.0506064440375393 1016 3400306
SGTC_1569 carminic acid 40.6 µM -1.63999504702354 0.0396939765003092 no 3222 0.0505030983930525 1037 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2281 7943571 200 µM -1.64792507606281 0.038979179756882 no 3223 0.0496840234685519 1039 1244024
SGTC_1337 1486-1011 40.3 µM -1.65208716017164 0.038608232766548 no 3224 0.0492583920186767 1036 X1337
SGTC_2782 7736369 71.43 µM -1.66258656479566 0.0376852390766882 no 3225 0.0481976111502677 1029 2950836 YOL077C BRX1
SGTC_1777 st045864 34.765 µM -1.66456307569267 0.0375135166306281 no 3226 0.0479999785882589 1063 4691462
SGTC_836 0330-0104 1.35 µM -1.6718979917135 0.0368818247956951 no 3227 0.0472722194434982 1021 46494820
SGTC_677 0929-0063 136 µM -1.67224432366891 0.0368522146088172 no 3228 0.0472380767632655 1071 1539583
SGTC_1491 4138-0063 26.5 µM -1.67274702322274 0.0368092701181037 no 3229 0.0471885539577961 1051 23883227
SGTC_2116 5511452 16.8835 µM -1.67650042025699 0.0364899177859589 no 3230 0.0468201069832215 1042 870744
SGTC_1098 clofazimine 15.1 µM -1.67817106979571 0.0363485039481018 no 3231 0.0466568538677459 1037 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_222 nsc-310342 10.666 µM -1.67942768657188 0.0362424321902205 no 3232 0.0465343605841539 1047 432556
SGTC_2049 5262831 67.185 µM -1.68193318386851 0.0360316980148689 no 3233 0.0462908985296239 1028 763417
SGTC_2709 st078560 56 µM -1.68531373485845 0.035748955773709 no 3234 0.0459640285899163 1052 17250903
SGTC_1916 st067606 49.2 µM -1.69525805873787 0.0349277583564717 no 3235 0.0450132386876981 1012 19590279
SGTC_3002 9075603 71.4286 µM -1.69585574167308 0.0348788993879752 no 3236 0.0449566015281769 1030 20105405
SGTC_274 sirtinol 40.1 µM -1.70393170834168 0.0342241949294201 no 3237 0.0441969231812181 1030 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3151 9099821 49.47 µM -1.71112017955798 0.0336499678374878 no 3238 0.0435294648465035 1032 17174189
SGTC_3051 9093778 49.47 µM -1.71166882560449 0.0336064687073062 no 3239 0.0434788583767526 1064 17217378
SGTC_2256 7954252 200 µM -1.71745452941529 0.0331505633661347 no 3240 0.0429480778618758 1061 2972920
SGTC_3049 9092223 49.47 µM -1.7246461616388 0.0325909880638776 no 3241 0.0422956295066916 1043 8623917
SGTC_3203 9113543 49.47 µM -1.72485072977883 0.032575185433221 no 3242 0.0422771883675305 1031 17018012
SGTC_2468 5987765 72.9 µM -1.72680562097533 0.0324244910882311 no 3243 0.0421012893347085 1047 26772094
SGTC_1373 2887-0003 58.5 µM -1.72852367017992 0.0322925291885423 no 3244 0.0419471905447663 1040 776948
SGTC_2047 4141938 200 µM -1.728664618719 0.0322817227519034 no 3245 0.0419345685934888 1056 3807862
SGTC_2239 6685329 187.64 µM -1.72948638235112 0.0322187780554023 no 3246 0.0418610408144415 1022 805680
SGTC_655 k060-0012 42 µM -1.73419499481633 0.0318600624492664 no 3247 0.0414417453745353 1051 5994525
SGTC_191 3914-0123 66.505 µM -1.74294944353966 0.0312018926871675 no 3248 0.0406712231329684 1061 3144412
SGTC_3197 9113331 49.47 µM -1.75122810184999 0.0305898790637216 no 3249 0.0399533133346199 1020 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_622 1348-1566 26.3 µM -1.76342305255876 0.0297064843453559 no 3250 0.0389145823055475 1050 7340407
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.77869894164159 0.0286298780893581 no 3251 0.0376445664031931 1058 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2907 7721985 69.9 µM -1.78332694603182 0.0283101856240668 no 3252 0.0372665487526658 1050 3267881
SGTC_2427 5545055 42.75 µM -1.78665417366374 0.0280821883861175 no 3253 0.036996700029046 1046 5372858
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.79801218736637 0.027315372303961 no 3254 0.0360875382337827 1055 16486 A toxic proline analog.
SGTC_982 1491-0518 27.5 µM -1.80126944209927 0.0270987146048522 no 3255 0.035830210902114 1049 3091256
SGTC_1316 1272-0050 65.9 µM -1.80793898172745 0.0266595598452608 no 3256 0.0353079989292685 1060 7340392
SGTC_447 ml7 120 µM -1.81433211099027 0.0262442010551011 no 3257 0.0348133053662087 1067 4216 Selective myosin light chain kinase inhibitor.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.81840391892381 0.0259824882759333 no 3258 0.0345012099189404 1065 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1945 st075991 56.6 µM -1.82181572536376 0.0257648810478219 no 3259 0.0342414754374928 1048 1084980
SGTC_1144 3486-0183 12.5 µM -1.82880488744843 0.025323868392545 no 3260 0.0337144212794284 1046 6744069
SGTC_560 2332-1943 155 µM -1.83359857661231 0.0250250595422842 no 3261 0.0333568018399982 1054 21177716
SGTC_2775 cyproheptadine 69.59 µM -1.84429966422594 0.0243686721378963 no 3262 0.0325697402075209 1047 2913 A selective serotonin reuptake inhibitor.
SGTC_1189 1431-2119 7.28 µM -1.8487792135573 0.0240982277530785 no 3263 0.0322448500148537 1054 3107275
SGTC_2575 plumbagin 510 nM -1.86110908416968 0.0233668268156694 no 3264 0.0313643868150444 1052 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2297 7971671 152.32 µM -1.86983921967421 0.0228603323251783 no 3265 0.0307530741182431 1045 909016
SGTC_1016 4226-1401 38 µM -1.87744961841888 0.0224263780189032 no 3266 0.0302282481766567 1057 2901613
SGTC_69 0096-0274 206.684 µM -1.8790949081568 0.022333480558338 no 3267 0.0301157676416439 1054 6741392
SGTC_2750 bromebric acid 70.15 µM -1.88107067519343 0.0222223526351146 no 3268 0.0299811527291566 1055 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_991 3996-0057 64.7 µM -1.88538194628757 0.0219814822984842 no 3269 0.0296891448377386 1055 715343
SGTC_433 pimozide 108 µM -1.886672135013 0.0219098295101454 no 3270 0.0296022189030585 1062 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3298 9116858 71.43 µM -1.88825004926461 0.0218224656044971 no 3271 0.0294961948265198 1073 2506942
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.89300868816517 0.0215607751302253 no 3272 0.029178357038511 1082 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1511 0906-3109 28.5 µM -1.90652020929515 0.0208321543196976 no 3273 0.0282913731213671 1061 2882180
SGTC_1806 st050005 60.3 µM -1.92083544971666 0.0200830439349517 no 3274 0.0273762278745005 1061 5194765
SGTC_583 1488-1091 88.9 µM -1.92793677215033 0.0197199935587004 no 3275 0.0269314955875217 1073 4303273
SGTC_1666 st014829 29 µM -1.92945304578921 0.0196432011303786 no 3276 0.026837321906121 1073 3858230
SGTC_636 0kpi-0074 126 µM -1.93021279654774 0.0196048187614816 no 3277 0.0267902383218644 1057 616434
SGTC_1466 k213-0079 57.5 µM -1.93616532794372 0.0193062972042743 no 3278 0.0264237277430001 1074 3657981
SGTC_1155 4088-0394 48.2 µM -1.94631052506675 0.0188064137601854 no 3279 0.025808725030666 1053 2326248
SGTC_2774 tamoxifen 10.92 µM -1.9541026727739 0.0184299886826305 no 3280 0.0253445380386852 1054 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2305 7443522 69.23 µM -1.96322876644605 0.0179973000412045 no 3281 0.0248097991149553 1041 5415886
SGTC_1622 st003707 19.4 µM -1.97416206129692 0.0174903599369907 no 3282 0.0241816591852583 1040 10140899
SGTC_798 1287-0182 476 µM -1.99125309223109 0.0167223448026446 no 3283 0.0232265348067635 1077 1649755
SGTC_1539 benzyladenosine 56 µM -2.02480863825584 0.0152981276667114 no 3284 0.0214435088646152 1065 92208 A nucleotide analog.
SGTC_793 0488-0545 106 µM -2.0352563051533 0.0148765173681136 no 3285 0.0209125451354128 1073 292548
SGTC_840 0245-0196 390 µM -2.03797017260541 0.0147686493283613 no 3286 0.0207764579579649 1075 3827528
SGTC_1187 1391-0724 117 µM -2.04202882594013 0.0146085856989125 no 3287 0.0205743360207428 1076 6997986
SGTC_226 1,3-diallylurea 8.28947 mM -2.043965090387 0.014532751467058 no 3288 0.0204784979954429 1072 74537 YKL182W FAS1
SGTC_1931 st074438 57.1 µM -2.0457827141753 0.0144618723808089 no 3289 0.0203888767341692 1075 2787313
SGTC_2097 5376186 200 µM -2.06307913913455 0.0138021500637489 no 3290 0.0195525549020437 1063 742755
SGTC_519 k048-0011 62.8 µM -2.06467465285876 0.0137426224821098 no 3291 0.0194768972232623 1055 6836379
SGTC_1572 epiandrosterone 68.9 µM -2.07353218395385 0.0134161656578413 no 3292 0.0190613895580842 1062 441302 A steroid.
SGTC_794 k038-0031 316 µM -2.07861601286958 0.0132318355612133 no 3293 0.0188263289986737 1057 6624242
SGTC_2043 5101342 149 µM -2.08976156702947 0.0128353607501251 no 3294 0.0183196116829095 1081 678451
SGTC_148 3253-0744 288.01 µM -2.13488466008582 0.0113334346009354 no 3295 0.0163852163219647 1056 6893655
SGTC_3337 9144342 33.5465 µM -2.1472024615492 0.0109509622853568 no 3296 0.0158885834182501 1070 17682949
SGTC_2499 avocadenofuran 51.48 µM -2.14765152844988 0.0109372333661999 no 3297 0.0158707243389419 1071 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3344 9148862 3.898 µM -2.14842067767869 0.0109137536484384 no 3298 0.01584017579533 1082 4905352
SGTC_228 caffeine 993.056 µM -2.16258273537459 0.0104892030252735 no 3299 0.0152866436607031 1074 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_186 3455-3465 67.277 µM -2.16652765619176 0.0103735351963553 no 3300 0.0151354444233075 1065 755278
SGTC_1177 0983-0204 23.6 µM -2.17221123795095 0.0102088441484294 no 3301 0.0149198667105509 1079 766818
SGTC_2821 7996764 71.43 µM -2.1788388313702 0.0100196831140945 no 3302 0.014671821570902 1050 2987135
SGTC_981 1488-1094 54.9 µM -2.19914906567681 0.00945892287364348 no 3303 0.0139336623315921 1071 3449522
SGTC_2605 digitonin 300 nM -2.20404549691009 0.00932791183040712 no 3304 0.0137605722928397 1077 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_965 1291-5240 308 µM -2.21605868920379 0.00901318644446105 no 3305 0.0133437414947567 1076 2834598
SGTC_2330 7979373 200 µM -2.23329920831211 0.00857777631995768 no 3306 0.0127646098499827 1057 1863007
SGTC_2776 terbinafine 19.92 µM -2.24111344271066 0.00838658089391175 no 3307 0.0125093638316833 1058 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1295 1013-0063 9.78 µM -2.24170060833548 0.00837236667142521 no 3308 0.0124903642733683 1075 6826038
SGTC_165 k038-0023 64.381 µM -2.2493708858958 0.00818861671151093 no 3309 0.0122444546553507 1073 46368543
SGTC_2997 9067075 71.4286 µM -2.25380207208064 0.00808408540676565 no 3310 0.0121043112041896 1061 27209819
SGTC_61 0978-8327 98.565 µM -2.26291966764728 0.00787268489242755 no 3311 0.0118203208811255 1065 6150059 YHR072W ERG7
SGTC_2809 7964133 12.99 µM -2.26778009783281 0.00776199029484866 no 3312 0.0116713065152261 1082 1253665
SGTC_2687 chenodiol 100 µM -2.27384090354799 0.00762587798968246 no 3313 0.0114877769651878 1061 5702181 A cholesterol synthesis inhibitor.
SGTC_2421 5690543 90.72 µM -2.294791685323 0.00717142115330711 no 3314 0.0108725326909672 1066 3397993
SGTC_1573 oleylamine 1.06 µM -2.31442049347604 0.00676749042378359 no 3315 0.0103223339106789 1067 5356789 An amine of the fatty acid oleic acid.
SGTC_2987 9018338 71.43 µM -2.34423168310454 0.00619244106718894 no 3316 0.00953316181410203 1076 5055682
SGTC_3178 9107506 49.47 µM -2.35187770177024 0.00605210974880753 no 3317 0.00933945758624929 1080 8897194
SGTC_304 1310-0298 97 µM -2.36343330392238 0.0058453708272139 no 3318 0.0090532427434111 1086 1550234
SGTC_2702 st077768 96.8 µM -2.39527831194152 0.00530769667563585 no 3319 0.00830387690962036 1076 6484119
SGTC_920 mycophenolic acid 780.421 nM -2.4184945340205 0.00494390407945204 no 3320 0.00779243985408147 1082 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.43104642281665 0.00475661785919617 no 3321 0.00752764272115917 1087 97141
SGTC_371 0195-0006 7.36 µM -2.43896330193383 0.00464176951401311 no 3322 0.00736473199539886 1054 3928593
SGTC_656 4090-1979 187 µM -2.46210390099017 0.00432012974214226 no 3323 0.00690623233188653 1082 22330961
SGTC_200 k038-0079 37.545 µM -2.4635607165036 0.00430056398906759 no 3324 0.00687822969720359 1089 3436683
SGTC_1749 st037932 54.2 µM -2.48542997675385 0.00401622081684901 no 3325 0.00646975203426686 1080 594497
SGTC_149 3970-0822 46.1 µM -2.4910806397784 0.0039455426853375 no 3326 0.00636776055219547 1074 3114250 YBL034C STU1
SGTC_1563 conessine 56.1 µM -2.51334646742876 0.00367776323029354 no 3327 0.00597959101523591 1079 441082 An anti-amoebic, histamine inhibitor.
SGTC_225 nsc-122657 1.016 µM -2.53278432593028 0.00345744873757796 no 3328 0.00565802773495006 1083 275685
SGTC_680 0417-1641 114 µM -2.54444627876529 0.00333103054228583 no 3329 0.00547255731280693 1081 2835990
SGTC_187 1488-2104 32.728 µM -2.54482206314422 0.00332702697244765 no 3330 0.00546667179051984 1083 2852859
SGTC_1253 0550-0034 176 µM -2.54883005358173 0.00328459459675639 no 3331 0.00540424784712071 1081 5969915
SGTC_1477 0139-0234 16 µM -2.57702650878832 0.00299958046056726 no 3332 0.00498271538882786 1086 620880
SGTC_1763 st044482 94.5 µM -2.60720241081305 0.00271941682496349 no 3333 0.00456426903876375 1080 88505
SGTC_1264 0783-0040 158 µM -2.62201042448485 0.00259076812904557 no 3334 0.00437063786062991 1079 2855798
SGTC_2569 tetrandrine 100 µM -2.63510486059169 0.00248161607305965 no 3335 0.00420556470576625 1079 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1673 st016611 27.3 µM -2.71483585945784 0.00190212534800448 no 3336 0.00331543131102752 1085 5226799
SGTC_2031 5180455 200 µM -2.78226320559305 0.00151120513259623 no 3337 0.00269906207654106 1089 29949
SGTC_989 1501-0895 10.3 µM -2.78485531814095 0.00149775663344936 no 3338 0.00267758060549715 1086 2830112
SGTC_3258 9138477 49.47 µM -2.78515529843873 0.00149620733352149 no 3339 0.00267510458902645 1094 4970355
SGTC_2266 7929956 200 µM -2.7865804204525 0.00148886699834778 no 3340 0.00266336995213423 1085 2967153
SGTC_857 0438-0306 1.35 µM -2.8441952872459 0.00121824618703284 no 3341 0.00222618748728157 1087 4686136
SGTC_2974 9094440 9.66 µM -2.85421122871177 0.00117607745770576 no 3342 0.00215719174022216 1083 25236134
SGTC_2498 4'-Methoxychalcone 54.63 µM -2.9043749910942 0.000984295613001072 yes 3343 0.00183993561523516 1090 641818 YHR062C RPP1
SGTC_1244 0416-0015 52.5 µM -2.92038337380447 0.000929422190374216 yes 3344 0.00174800511238351 1092 96201
SGTC_1062 mesoridazine 14.2 µM -2.97950325507849 0.000750235543312901 yes 3345 0.00144358081170671 1088 4078 A neuroleptic.
SGTC_2029 5175081 200 µM -3.08355228861616 0.000510055717641514 yes 3346 0.00102272580789733 1091 1380876
SGTC_1738 st035555 74 µM -3.08792875309749 0.000501718852652415 yes 3347 0.00100778393597259 1086 5331140
SGTC_802 4112-3352 742 µM -3.2071368466977 0.0003177843157796 yes 3348 0.000670316029280929 1094 704594
SGTC_3058 9093861 49.47 µM -3.21019415001136 0.000314022088669174 yes 3349 0.00066322673014455 1089 17217477
SGTC_2606 farnesol 9.78 µM -3.25523564726344 0.000263185684328075 yes 3350 0.000566491582865907 1087 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2706 st078239 82.5 µM -3.32843418357722 0.000196619281549747 yes 3351 0.000436678191030323 1093 15434492
SGTC_2978 9011784 42.97 µM -3.46121290986193 0.000114184432700345 yes 3352 0.000268873669045696 1091 2994934
SGTC_1502 4534-4282 27.7 µM -3.53024210821783 8.54446764318996e-05 yes 3353 0.000207589776437749 1095 3278949
SGTC_2054 5233173 129 µM -3.5936281308488 6.51798391004795e-05 yes 3354 0.000163052584829465 1031 6889
SGTC_2048 5246248 200 µM -3.67178639244436 4.64060797161639e-05 yes 3355 0.000120430481986831 1092 677046
SGTC_74 000s-0487 160.283 µM -5.20226252687738 1.58761580102122e-08 yes 3356 9.84384228942158e-08 1095 677548