SGTCid condition conc unit SKI3|YPR189W.score SKI3|YPR189W.strain.pval SKI3|YPR189W.strain.significant SKI3|YPR189W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1393 3470-5649 58.2 µM 5.39135148088913 6.36706598869016e-09 yes 1 3.4964871211614e-08 4 4108395
SGTC_2314 7727897 200 µM 4.85205225527952 1.49206095841347e-07 yes 2 6.10952078696311e-07 4 900724
SGTC_744 1594-0068 283 µM 4.77770518502594 2.24945413849976e-07 yes 3 8.86535427895127e-07 13 668392
SGTC_1450 4112-4260 37.6 µM 4.75241917903573 2.58305469854999e-07 yes 4 1.00498561644765e-06 16 1633175
SGTC_2059 5238311 157 µM 4.47805960522619 1.10869737425566e-06 yes 5 3.76622861303078e-06 12 703021
SGTC_2390 9097792 176.6 µM 4.29717268033814 2.77332602209264e-06 yes 6 8.64952162246348e-06 8 4497149
SGTC_1821 st053465 65.6 µM 3.98956741653206 1.21813631614513e-05 yes 7 3.30969520336456e-05 5 675086
SGTC_246 cycloheximide 667 µM 3.93365312923266 1.57715775752844e-05 yes 8 4.1832248219749e-05 14 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1015 4130-4525 82 µM 3.88645170645182 1.95642977655078e-05 yes 9 5.08600757656567e-05 23 1363237
SGTC_2569 tetrandrine 100 µM 3.86011816192545 2.20412495346559e-05 yes 10 5.66661042686329e-05 23 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1809 st050081 57.6 µM 3.85843913962104 2.22088704788787e-05 yes 11 5.70567376462614e-05 16 5036894
SGTC_789 1309-1135 70.6 µM 3.80818742154415 2.78232078675855e-05 yes 12 6.99945784559555e-05 35 3092424
SGTC_1605 st000082 49.1 µM 3.78746890465727 3.05090289366553e-05 yes 13 7.60948621385886e-05 19 1114022
SGTC_3287 9117173 37.0625 µM 3.73221815868346 3.89224393507195e-05 yes 14 9.49005043468255e-05 6 2789709
SGTC_2195 6536160 144.242 µM 3.71845442619424 4.13364759769067e-05 yes 15 0.000100222722702508 15 3834386
SGTC_2348 9022543 33.42 µM 3.67800821793794 4.92755523149926e-05 yes 16 0.000117531194057873 34 3162678 YDL140C RPO21
SGTC_1399 3562-5772 25 µM 3.63166183347573 6.01377463504036e-05 yes 17 0.000140800988584058 23 23847490
SGTC_1534 6-azauridine 81.6 µM 3.56911213692838 7.84090547622822e-05 yes 18 0.000179096546893981 40 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1701 st028638 40.4 µM 3.56155656674143 8.09401394011596e-05 yes 19 0.000184331328613303 24 3490878
SGTC_265 mycophenolic acid 32.932 µM 3.51345407472119 9.8946725107816e-05 yes 20 0.000221160435013924 37 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2520 obtusaquinone 4.71 µM 3.42360421205087 0.000143070426138713 yes 21 0.00030898276171012 34 5967872
SGTC_1273 0849-0096 14.1 µM 3.42359935302277 0.000143073246819959 yes 22 0.000308988285866814 39 5286025
SGTC_2099 5377090 177.372 µM 3.27565271187368 0.000257825681926238 yes 23 0.000527090520393338 50 2243829
SGTC_935 2996-0153 430 µM 3.2674596685587 0.000266196498960146 yes 24 0.000542586635424013 43 23738523
SGTC_876 0720-0963 56.8 µM 3.24902770644055 0.000285962718152072 yes 25 0.000579000992749602 38 765861
SGTC_2193 5925765 200 µM 3.24282816189465 0.000292912501619507 yes 26 0.000591747837483609 14 877370
SGTC_2817 7995342 71.43 µM 3.19493018103248 0.000352149728870563 yes 27 0.000699323358851579 50 18879975
SGTC_925 2064-1272 59.6 µM 3.19111650545453 0.000357315571171329 yes 28 0.000708620590891051 50 6815817
SGTC_3212 9128307 49.47 µM 3.17335036721605 0.000382321995224593 yes 29 0.000753452773669065 84 27243542
SGTC_49 0717-0965 32.132 µM 3.17146244987733 0.000385072716234823 yes 30 0.000758367377595539 53 5889349 YGL099W LSG1
SGTC_105 0111-0055 734.78 µM 3.12264488285043 0.000462909336142627 yes 31 0.000896169321074832 31 5179370
SGTC_2888 9058547 12.99 µM 3.11665635879584 0.000473402386433787 yes 32 0.000914573261149488 28 16476514
SGTC_183 3914-0051 30.55 µM 3.10248953790152 0.000499108656758286 yes 33 0.000959501654121139 60 1596232
SGTC_1429 4049-0205 9.46 µM 3.07825876345127 0.000546091664520313 yes 34 0.0010410701581172 36 22774478
SGTC_1752 st044819 83.042 µM 3.07606262313198 0.000550546110375654 yes 35 0.00104876893061895 57 441209 YML126C ERG13
SGTC_2563 tomatine 8.54 µM 3.07552228676116 0.000551647216749246 yes 36 0.00105067111673344 100 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3126 9127922 49.47 µM 3.06986113683559 0.000563306672125478 yes 37 0.00107079159023527 81 45595682
SGTC_937 3122-0005 46.7 µM 3.03055331975757 0.000650759514321134 yes 38 0.00122053041001645 62 759535
SGTC_3249 9135183 49.47 µM 3.02080268515769 0.000674312119168418 yes 39 0.00126052794123834 55 4902779
SGTC_3 0833-0587 95.581 µM 3.01423946865956 0.00069060566962808 yes 40 0.00128812185883133 56 5382644
SGTC_395 anisomycin 6.25 µM 2.96275441022658 0.000831581291199457 yes 41 0.00152449864672687 29 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2010 4012422 159 µM 2.95555548602503 0.000853278800957579 yes 42 0.00156053276032877 73 952393
SGTC_673 1082-0474 110 µM 2.94021432732444 0.000901264494524981 yes 43 0.00163992644052267 130 3098046
SGTC_2200 6600604 21.907 µM 2.92629292749533 0.000946943164895949 yes 44 0.0017151389028102 106 2904777
SGTC_62 0180-0423 3.232 µM 2.91042957785665 0.00100158000396596 no 45 0.00180466147109217 65 30102 YGL099W LSG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.90943930104238 0.00100508485069554 no 46 0.00181038844378588 64 16623 A steroid.
SGTC_1348 1493-0373 93.8 µM 2.87144143801327 0.00114837947086149 no 47 0.00204302241618292 59 3010129
SGTC_1908 st060353 56.5 µM 2.857999613939 0.00120339444693483 no 48 0.0021316045510353 95 4227716
SGTC_1461 k072-0203 53.8 µM 2.84416268352223 0.00126253721802201 no 49 0.00222641530964113 70 5418714
SGTC_253 dyclonine 31.25 µM 2.83226868467565 0.00131548759149506 no 50 0.00231094967758621 90 3180 An oral anasthetic.
SGTC_1194 1488-0194 225 µM 2.7819972657062 0.00156245673402141 no 51 0.00270127476319244 101 1391452
SGTC_685 1278-0033 54.9 µM 2.77615193228895 0.00159376256016079 no 52 0.0027503248590578 91 3590572
SGTC_1426 4048-4480 71.7 µM 2.76689350466832 0.00164451928180839 no 53 0.00282966195010118 73 14224343
SGTC_618 k072-0232 33.2 µM 2.74899652347365 0.00174682987263178 no 54 0.00298890101235886 58 5872756 YGL099W LSG1
SGTC_2547 epiafzelechin trimethyl ether 100 µM 2.74882938674271 0.00174781204761688 no 55 0.0029904254300307 30 6708630 An antioxidant.
SGTC_2713 st079149 53.4 µM 2.73766456581467 0.00181457116324847 no 56 0.00309385764781796 91 3103253
SGTC_1825 st052143 62.6 µM 2.70474373707848 0.00202513914048976 no 57 0.00341785504321029 67 674173
SGTC_2667 digitoxin 100 µM 2.69462222545996 0.00209420019469813 no 58 0.00352342380485493 37 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_103 0844-0104 51.839 µM 2.69081929649937 0.00212069569982773 no 59 0.0035638395529388 247 5375804
SGTC_2412 st077135 33.4 µM 2.68568581101593 0.00215694356473722 no 60 0.00361905581687449 109 13258915
SGTC_722 3534-0461 190 µM 2.68389042093985 0.00216975292061249 no 61 0.00363854766389535 121 658262
SGTC_765 1319-0117 244 µM 2.68063270265749 0.00219317160121205 no 62 0.00367415611424136 72 3487746 YGL099W LSG1
SGTC_1787 fluconazole 80 µM 2.66219908930245 0.00233005420948392 no 63 0.00388159732760123 138 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2894 9048625 32.47 µM 2.65370269202116 0.00239571272636213 no 64 0.00398069696112172 75 4092861
SGTC_1628 st004252 77.7 µM 2.64677007169357 0.00245052214165702 no 65 0.00406322930174769 104 692968
SGTC_1750 st081859 2.357 µM 2.6267665447105 0.00261508667868796 no 66 0.00431002257538603 315 5291695
SGTC_3332 9141069 11.198 µM 2.6236368272316 0.00264171874520466 no 67 0.0043498246860438 85 17332883
SGTC_3142 9086498 49.47 µM 2.61755894456459 0.00269413888201081 no 68 0.00442805956159105 103 25236367
SGTC_2112 5488546 200 µM 2.60384077891401 0.00281592250019783 no 69 0.00460927858568631 97 600757
SGTC_383 2324-0395 7.37 µM 2.60295369926212 0.00282396595611408 no 70 0.00462122173507949 138 3146421
SGTC_2236 dapsone 200 µM 2.58605974273896 0.00298115773196614 no 71 0.00485400510889233 77 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_687 k029-0044 34.9 µM 2.5769201256652 0.00306944582269222 no 72 0.00498424913416608 97 5829338
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.55280035843077 0.00331385663651664 no 73 0.00534303640499401 110 6708760
SGTC_3208 9114115 49.47 µM 2.54629897781489 0.00338266385612963 no 74 0.00544359486341058 137 650895
SGTC_2192 5915882 198.485 µM 2.54475803645465 0.00339915945287044 no 75 0.00546767417665211 74 2876149
SGTC_1856 st057054 55.7 µM 2.54427013989728 0.0034043973754781 no 76 0.0054753179315362 105 1266018
SGTC_2288 7946289 167.31 µM 2.53504525126621 0.00350480782597843 no 77 0.00562164006452893 125 1246052
SGTC_924 2046-0044 21.3 µM 2.53444813670876 0.00351139799328828 no 78 0.00563122986544894 96 3623589
SGTC_1248 0469-0687 58.6 µM 2.52067977620872 0.00366647428872277 no 79 0.00585641947872711 130 4017482
SGTC_135 0933-0004 26.348 µM 2.51532481987195 0.00372842936233992 no 80 0.00594613805941173 120 21230617 YGL099W LSG1
SGTC_1129 3453-1384 223 µM 2.50373956253153 0.00386569050553848 no 81 0.0061444227509803 153 1084452
SGTC_4 0960-0234 25.671 µM 2.49941515863801 0.00391807515049929 no 82 0.00621992409819105 91 6821112
SGTC_2022 5136654 200 µM 2.4988801227757 0.00392460044127856 no 83 0.0062293223701794 103 1713771
SGTC_2215 7188065 200 µM 2.48370722748229 0.00411374846574691 no 84 0.00650113289714358 73 940217
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.48278922288218 0.00412544993578957 no 85 0.00651790980109739 180 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2307 7538926 6.34 µM 2.47599169633544 0.00421302633225825 no 86 0.0066433334167535 159 96582
SGTC_2518 prenyletin 46.28 µM 2.46378635379953 0.00437445628943265 no 87 0.00687390151924597 58 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2927 9011802 47.9 µM 2.46094260409454 0.00441285312456213 no 88 0.00692862662294087 133 43912568
SGTC_1695 st026914 34.495 µM 2.4523729435876 0.0045303896016579 no 89 0.00709587442577398 124 3289191
SGTC_2707 st078556 66.6 µM 2.43305116295625 0.00480570860890843 no 90 0.00748609256209748 77 17250899
SGTC_860 0443-0016 25.1 µM 2.41492451601907 0.00507745893184383 no 91 0.00786923546509933 124 5337942
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.40672989102194 0.00520474003845714 no 92 0.00804803491005519 141 5282309
SGTC_3263 9137018 49.47 µM 2.39558404324309 0.00538241484107402 no 93 0.00829695478437597 124 43844957
SGTC_1664 st014217 9.02 µM 2.39538091978969 0.00538570224137719 no 94 0.00830155317903017 114 3982782
SGTC_2024 5144227 134 µM 2.38187929070068 0.00560825865093368 no 95 0.00861227124109541 154 3475211
SGTC_1462 k081-0014 26.5 µM 2.37594778967491 0.00570858736046313 no 96 0.00875196967630807 75 3270634
SGTC_1447 4239-0816 81.9 µM 2.37190261180128 0.00577792040646395 no 97 0.00884837727279252 151 1341554
SGTC_988 1497-1057 103 µM 2.37111808287311 0.00579145316629732 no 98 0.00886718211437706 125 3533044
SGTC_2358 9037157 4 µM 2.36814195339859 0.00584304608131443 no 99 0.00893883753888662 148 2388925
SGTC_2340 7987427 183.45 µM 2.36473966445267 0.00590252586068719 no 100 0.00902137451084228 151 2239331
SGTC_1037 k284-1091 78.7 µM 2.34969075351483 0.00617210416047703 no 101 0.00939450701502377 110 3334711
SGTC_1042 0350-0096 82 µM 2.34857679687028 0.00619248586992947 no 102 0.00942265625779813 128 3122515
SGTC_645 0845-0943 5.41 µM 2.34543555907092 0.00625028152555894 no 103 0.00950243176463891 117 1885106
SGTC_759 3486-0358 89.3 µM 2.32466834444822 0.00664453865645067 no 104 0.0100448506028821 154 875103
SGTC_3292 9120825 59.784 µM 2.32109494311008 0.0067145516517236 no 105 0.0101408601290092 134 24824900
SGTC_3202 9113761 49.47 µM 2.31078375162514 0.0069202451014422 no 106 0.0104224012185444 205 4798415
SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.30957479659637 0.00694472275752409 no 107 0.0104558531405681 128 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_584 0986-0246 15.4 µM 2.30607971728066 0.00701591792590822 no 108 0.0105530892066832 140 53315 YDR232W HEM1
SGTC_1256 0570-0116 285 µM 2.3060172533164 0.00701719616212204 no 109 0.0105548341489634 152 410638
SGTC_2977 9011197 71.43 µM 2.30074338164668 0.00712586250647495 no 110 0.0107030702154748 107 2704722
SGTC_2532 xanthone 78.9 µM 2.28204918590386 0.00752310149371945 no 111 0.0112432182607065 150 7020 An insecticide.
SGTC_3231 9132313 49.47 µM 2.2800256795932 0.00756724818841388 no 112 0.0113030827431703 124 4905967
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.2735222780958 0.0077106811588703 no 113 0.0114973625824973 163 5393153
SGTC_1928 4'-methoxychalcone 40.3 µM 2.273050880202 0.00772117027973314 no 114 0.0115115569906137 123 641818
SGTC_2101 5377231 179.231 µM 2.27042778869309 0.00777976662304939 no 115 0.0115908200133653 117 2844213
SGTC_1487 3970-0795 2.82 µM 2.26625008070934 0.0078738990399782 no 116 0.0117180379644617 140 3765103
SGTC_2212 7123476 200 µM 2.24901191676019 0.00827298791668917 no 117 0.0122558689549509 83 1085715
SGTC_1805 st050013 60.3 µM 2.24560945028487 0.0083538265690593 no 118 0.0123645173188305 120 4037144
SGTC_219 mitoxanthrone 164.414 µM 2.2404334614387 0.00847813211730762 no 119 0.0125313979915217 184 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_408 cantharidin 100 µM 2.23409992891514 0.00863244315874542 no 120 0.0127382493476001 175 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2313 7726885 200 µM 2.23333374779954 0.0086512765197119 no 121 0.012763471803189 182 726423
SGTC_671 0560-0003 407 µM 2.22742883022431 0.008797637266387 no 122 0.0129593136959466 145 3238678
SGTC_3131 9127911 49.47 µM 2.22024867561139 0.00897852700288047 no 123 0.0132009458966379 169 45595681
SGTC_1771 st048882 4.1505 µM 2.21849490351249 0.00902320181454719 no 124 0.0132605533505569 155 4580403
SGTC_3093 9117344 49.47 µM 2.21572601359815 0.00909413165974232 no 125 0.0133551360984863 156 24824913
SGTC_1730 st033808 45.1 µM 2.21304362913855 0.00916331061737524 no 126 0.013447318936096 232 1045166
SGTC_1841 st054148 70 µM 2.20828757619435 0.0092871027464138 no 127 0.0136121164145575 149 675442
SGTC_1624 st003710 6.25 µM 2.18429148815165 0.00993425184098283 no 128 0.0144704179210901 214 24207033
SGTC_503 tyrphostin 8 294 µM 2.17324782401219 0.0102450885575999 no 129 0.0148808350633004 199 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_97 0535-0701 19.132 µM 2.16897876327925 0.0103675002739723 no 130 0.01504214812074 156 2832013 YGL099W LSG1
SGTC_2885 9057732 51.95 µM 2.16312640480255 0.0105373828066704 no 131 0.0152657293643872 167 6471414
SGTC_1631 benzylvanillin 81.9 µM 2.16277685130385 0.0105476059832938 no 132 0.0152791734359776 194 75506
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.16077339489301 0.0106063666995281 no 133 0.0153564240923936 242 688788
SGTC_2171 5739187 198.077 µM 2.15987619750424 0.0106327735125677 no 134 0.0153911274300876 133 2262761
SGTC_2311 7694451 200 µM 2.15535352444717 0.0107667610214996 no 135 0.0155670901440825 185 2163142
SGTC_1590 st077108 57.8 µM 2.15393698007815 0.0108090283930523 no 136 0.0156225572041112 126 5489485
SGTC_928 2764-0428 58.7 µM 2.15310602844607 0.0108338897901174 no 137 0.0156551732941301 223 662578
SGTC_2442 5158906 48.48 µM 2.14661218625026 0.0110299004744604 no 138 0.0159120844665093 182 1893835
SGTC_1392 3455-1037 33.9 µM 2.14575256738715 0.0110560771024861 no 139 0.0159463623821909 164 981132
SGTC_1062 mesoridazine 14.2 µM 2.14450648424532 0.0110941180511606 no 140 0.0159961632187693 193 4078 A neuroleptic.
SGTC_1164 k060-0068 93.7 µM 2.14194608229002 0.0111726404695989 no 141 0.0160989105147603 200 5963676
SGTC_1023 4482-3888 16 µM 2.14144542434708 0.01118805100499 no 142 0.0161190675681972 166 3303168
SGTC_1764 st044502 93.5 µM 2.13710997546718 0.0113222732634239 no 143 0.016294523894831 199 8407
SGTC_56 0957-0365 83.25 µM 2.13215291622559 0.0114774528480422 no 144 0.0164971388393009 216 6752360
SGTC_962 1254-0300 21.5 µM 2.13179622735971 0.0114886898208283 no 145 0.0165118009633868 159 7340576
SGTC_2014 4013930 200 µM 2.13103175468362 0.0115128056313036 no 146 0.0165432631071035 219 64556
SGTC_1689 st020265 53.493 µM 2.12261839794448 0.011781128624139 no 147 0.0168929209958757 161 5758320 YPR016C TIF6
SGTC_1339 1486-1321 22.7 µM 2.12116038799127 0.0118281757954877 no 148 0.0169541537483916 202 3469382
SGTC_258 haloperidol 50.781 µM 2.12093054077738 0.0118356073774341 no 149 0.0169638240485026 232 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1180 1193-0155 285 µM 2.09130979328341 0.0128278643869259 no 150 0.0182501512492392 191 2921347
SGTC_3246 9135460 32.98 µM 2.07616453611918 0.0133624550099725 no 151 0.018939368010662 121 41446951
SGTC_1058 3448-5425 97.3 µM 2.07406746783321 0.0134379721909161 no 152 0.0190365227011736 204 7279705
SGTC_2630 antimycin a 100 µM 2.06701734582214 0.0136945609419832 no 153 0.0193662597606639 233 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1645 Cervolide 78 µM 2.06083992001055 0.0139228515898 no 154 0.0196591573072143 146 23173 A fragrance.
SGTC_1909 st060837 51.5 µM 2.04788926099569 0.0144121209711759 no 155 0.0202854256810326 236 678937
SGTC_3222 9128301 49.47 µM 2.04074029820418 0.0146884935861588 no 156 0.0206383237782685 204 4911358
SGTC_969 1313-0238 134 µM 2.03461666888747 0.014928841251506 no 157 0.0209447294093878 256 5212874
SGTC_1018 4259-0013 28.1 µM 2.0341033030266 0.014949143201248 no 158 0.0209705905116099 196 6801262
SGTC_8 0354-0001 70 µM 2.03262433921762 0.0150077641427892 no 159 0.0210452452898447 315 4993152
SGTC_766 1391-0721 126 µM 2.02640822492505 0.0152563144598123 no 160 0.0213614843975446 198 1020919 YIL115C NUP159
SGTC_2346 9031566 143.75 µM 2.02062615987453 0.0154906751396099 no 161 0.0216592394082602 190 4771086
SGTC_2816 7982706 58.44 µM 2.01720988379443 0.0156305919751029 no 162 0.0218368075344034 251 2981853
SGTC_1665 st014639 11.4 µM 2.01572143585642 0.0156918911049011 no 163 0.0219145564088903 242 981133 YIL048W NEO1
SGTC_1011 4112-3381 17.4 µM 2.01398582479166 0.0157636295605509 no 164 0.0220055108836612 243 2877139
SGTC_2420 aureobasidin a 50 nM 2.00088866420263 0.0163141035224471 no 165 0.0227021947279964 276 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3190 9110366 49.47 µM 1.99486704854546 0.0165726666491775 no 166 0.0230286911225157 162 17123768
SGTC_2867 9039098 71.43 µM 1.98259722403342 0.017110391469953 no 167 0.0237062188537705 246 6463460
SGTC_652 0437-0092 114 µM 1.97323694574418 0.0175305681949174 no 168 0.0242342865042057 196 3091274
SGTC_2128 5255449 168.493 µM 1.96277114897725 0.0180107706229058 no 169 0.0248363858042708 265 736008
SGTC_2751 anetholtrithion 17.25 µM 1.9577275550778 0.0182461623243726 no 170 0.0251309950539165 232 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1340 1486-1359 257 µM 1.95535682619314 0.0183577102022374 no 171 0.0252704841160189 224 4309068
SGTC_431 k089-0097 107 µM 1.95097618557957 0.0185653575346358 no 172 0.0255299393733902 315 5499420
SGTC_2627 acetyl isogambogic acid 100 µM 1.94583025838908 0.0188118313815133 no 173 0.0258375663205492 259 6857789 A caspase activator and apoptosis inducer.
SGTC_1993 st073995 70.8 µM 1.94547822384844 0.0188287940133679 no 174 0.0258587240556782 207 3098394
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.94232351839189 0.0189813838052845 no 175 0.0260489738153745 224 7104
SGTC_1156 4092-0367 4.88 µM 1.93325743155319 0.0194257674133941 no 176 0.0266022464828223 253 1357585
SGTC_2182 6325192 200 µM 1.93276785823982 0.0194500138144079 no 177 0.0266324007599326 201 736248
SGTC_599 1935-0052 86.5 µM 1.93214079367741 0.0194811070972279 no 178 0.0266710652324785 246 9557311
SGTC_1351 1496-0003 46.5 µM 1.92451142853715 0.0198628068943629 no 179 0.0271452548029744 232 3891978
SGTC_841 0251-0215 91.2 µM 1.92395431449758 0.0198909264541963 no 180 0.0271801551016677 316 3888614
SGTC_357 1325-0123 420 µM 1.91045126102103 0.0205828772826192 no 181 0.0280375680463333 203 1098503
SGTC_2671 danthron 100 µM 1.9096563374267 0.0206242402087146 no 182 0.0280887381158231 256 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_612 0302-0167 22.4 µM 1.90094989881116 0.0210818965556737 no 183 0.0286542876524676 312 235821
SGTC_1629 st005085 44.9 µM 1.89933531634481 0.0211677052085465 no 184 0.0287602011238725 271 24207091
SGTC_3073 9114972 49.47 µM 1.89867979890212 0.0212026275897468 no 185 0.0288032945980347 214 41905075
SGTC_959 1222-0044 107 µM 1.89515496322698 0.0213912481805148 no 186 0.0290359373756422 254 6083612
SGTC_3002 9075603 71.4286 µM 1.8824186489647 0.0220846586470749 no 187 0.0298895979011234 258 20105405
SGTC_844 0330-0132 15.3 µM 1.88107846799379 0.0221587139491399 no 188 0.0299806227719556 243 2828079
SGTC_2913 7966556 36.57 µM 1.87966785860635 0.0222368872275241 no 189 0.0300766793276758 216 2976516
SGTC_2594 a-mangostin 100 µM 1.87753207498606 0.0223556910880036 no 190 0.0302226027418252 288 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.87705205196528 0.0223824661339493 no 191 0.0302554800535926 263 6708514
SGTC_1713 st033146 12.748 µM 1.87444120525998 0.0225285697764349 no 192 0.0304348193156196 270 674619
SGTC_2424 5537928 59.2 µM 1.8712819550832 0.0227064366727323 no 193 0.0306530051722638 301 5382802
SGTC_3300 9124615 50.48 µM 1.86993963830726 0.0227823670682649 no 194 0.0307461002782281 279 24824903
SGTC_280 3448-3607 3.04 µM 1.86536127713302 0.0230429610879909 no 195 0.0310653906402771 211 626179
SGTC_851 0394-0702 453 µM 1.8638274195872 0.0231308256310618 no 196 0.0311729719338116 259 762646
SGTC_3033 9090887 49.47 µM 1.85801512102217 0.0234663376800269 no 197 0.0315834335175608 300 19325384
SGTC_2247 cerulenin 830 nM 1.85172339255494 0.0238341300837483 no 198 0.0320327765644837 261 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2104 5389443 200 µM 1.85095069980933 0.0238796313111103 no 199 0.0320883229576475 296 2244536
SGTC_568 1193-0097 7.48 µM 1.84834434095673 0.0240336496932521 no 200 0.0322762725174555 392 3646150
SGTC_748 act1.228 77.9 µM 1.84014279010741 0.024523762281354 no 201 0.0328736382693833 345 4421505 YNR035C ARC35
SGTC_534 k292-0788 63.4 µM 1.8321192415129 0.0250113278649782 no 202 0.0334668286210563 309 4146317
SGTC_2643 anethole 100 µM 1.82723344599747 0.0253121840447958 no 203 0.0338323385485625 299 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_552 k242-0005 476 µM 1.82439697868699 0.0254882341432253 no 204 0.0340460392204491 238 4088318
SGTC_501 nsc-95397 161 µM 1.81894400992606 0.0258295628884582 no 205 0.0344599862884124 221 262093
SGTC_826 1683-5028 118 µM 1.81606627968794 0.0260112311105187 no 206 0.0346801027850812 248 722377
SGTC_1230 0170-0365 3.77 µM 1.81086948368036 0.0263420074485457 no 207 0.035080528683016 421 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2175 5807670 165.306 µM 1.79691072000323 0.027247928277385 no 208 0.0361748972523125 262 241186
SGTC_1863 st057641 20.1 µM 1.79524398683501 0.0273578155768518 no 209 0.0363074175200251 300 3921635
SGTC_1416 3966-0321 25.3 µM 1.78569715837066 0.0279943796276116 no 210 0.0370741528637781 301 582530 YLR208W SEC13
SGTC_3091 9116372 49.47 µM 1.7845299629766 0.0280730455274509 no 211 0.0371687952496878 268 17169793
SGTC_3164 9100705 49.47 µM 1.78356776084417 0.0281380337590362 no 212 0.0372469640758488 212 17174235
SGTC_1341 1486-1360 280 µM 1.77802183961664 0.028515057647017 no 213 0.0377001340217609 308 3976547
SGTC_1320 1313-0481 95.3 µM 1.76095187615453 0.0297019724035839 no 214 0.0391232742607105 292 6813365 YLR208W SEC13
SGTC_2065 5221596 34.26 µM 1.75985657868712 0.0297795103008355 no 215 0.0392160635591736 284 788581
SGTC_1174 0739-0097 51.1 µM 1.75210564329158 0.0303330236465588 no 216 0.0398778220436629 319 728447
SGTC_2959 9079155 11 µM 1.75200827652377 0.0303400307017037 no 217 0.0398861923847239 260 16189457
SGTC_359 0081-0058 15.9 µM 1.75040881071934 0.0304553292962996 no 218 0.0400238983858194 317 3494159
SGTC_1140 3229-1848 2.98 µM 1.7455009802573 0.0308113814062638 no 219 0.0404488509858172 247 2849525
SGTC_1053 3366-3204 134 µM 1.74114324846182 0.0311304067606319 no 220 0.0408292360451309 337 3632071 YPR165W RHO1
SGTC_100 0086-0128 49.5915 µM 1.7398850612839 0.0312230241962315 no 221 0.0409396011555706 380 93297
SGTC_773 4358-1457 44.6 µM 1.73906799379271 0.0312832919861144 no 222 0.0410114018342395 367 1186886
SGTC_2176 5809774 33.9695 µM 1.7365795522356 0.0314674351004631 no 223 0.0412307056747368 289 2870539
SGTC_2159 5658611 73.75 µM 1.73089276551582 0.0318916190440383 no 224 0.0417354460954905 253 793844
SGTC_1107 amlodipine 47 µM 1.73029730108446 0.0319363073015215 no 225 0.0417885857569511 326 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3144 9087057 49.47 µM 1.72495881961629 0.0323392629134079 no 226 0.0422674470543062 311 17249618
SGTC_115 0527-0192 112.043 µM 1.71305402684446 0.033252974269096 no 227 0.0433513003335335 432 4233931
SGTC_2847 9005661 71.43 µM 1.71284340577816 0.033269329235463 no 228 0.0433706761447305 184 2991449
SGTC_1663 st014140 55.4 µM 1.71140667715806 0.0333810696698746 no 229 0.0435030327150079 344 4207120
SGTC_1473 k844-0725 134 µM 1.70493687271468 0.0338880891203339 no 230 0.0441030992659269 348 54682906
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.70405242755493 0.0339578901027369 no 231 0.0441856465304825 360 6708784 An antioxidant flavonoid
SGTC_23 0213-0011 39.996 µM 1.70350732068205 0.0340009691558854 no 232 0.0442365845929425 306 627608
SGTC_546 peri-Naphthalide 147 µM 1.70306591679735 0.0340358856256896 no 233 0.0442778666983958 315 223824 A penicillin ester.
SGTC_800 3448-7362 155 µM 1.69917741829566 0.0343447541166605 no 234 0.0446428799172077 618 15991913
SGTC_1010 4112-3296 15.2 µM 1.68560099929519 0.035441256074523 no 235 0.0459363383118594 365 704384
SGTC_3148 9097893 49.47 µM 1.68318900618334 0.0356390323822852 no 236 0.0461692541902837 344 17174100
SGTC_1221 2958-7315 257 µM 1.68309749343063 0.035646553934052 no 237 0.0461781098272733 334 4562705
SGTC_1453 4237-0541 195 µM 1.6802922589667 0.0358777517673157 no 238 0.0464502332273612 313 739892
SGTC_1161 k007-0610 110 µM 1.6743305253215 0.0363731780105137 no 239 0.0470328292379973 456 5843850
SGTC_140 0062-0056 502.533 µM 1.67268106876654 0.036511234138919 no 240 0.0471950490040624 371 3758964
SGTC_1192 1488-0095 21.4 µM 1.66827338873906 0.0368822526053145 no 241 0.0476307340407728 322 915875
SGTC_791 1348-1292 225 µM 1.66800974199435 0.0369045425441124 no 242 0.047656896445595 424 5437054
SGTC_829 1635-0120 117 µM 1.66654642248928 0.0370284587644558 no 243 0.0478023150181779 382 285054
SGTC_1242 0402-0103 60.1 µM 1.66192782071688 0.0374218016844505 no 244 0.0482636238485988 313 432868
SGTC_2511 berberine 10.47 µM 1.65825658484884 0.0377368910123319 no 245 0.0486328439788652 312 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_154 3389-1638 511.116 µM 1.657933178986 0.0377647512830766 no 246 0.048665477180705 312 5238686
SGTC_1609 st001574 46.4 µM 1.65587696703394 0.0379422795919475 no 247 0.0488733684656581 338 3960012
SGTC_2745 rifampicin 24.3 µM 1.65423485738254 0.0380845438401717 no 248 0.0490399014997828 187 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2387 9077560 195.08 µM 1.65356171982324 0.0381429867416534 no 249 0.049108297984547 345 5303272
SGTC_3245 9134821 49.47 µM 1.64843062870576 0.038590884114353 no 250 0.0496321675776817 368 17014901
SGTC_2325 6158266 200 µM 1.6464357777327 0.0387661693540271 no 251 0.0498370360751982 342 3623240
SGTC_334 1502-1024 68.5 µM 1.64606629084727 0.0387987068169094 no 252 0.0498750558148577 352 3296216
SGTC_1043 0916-0009 19.3 µM 1.64039025373453 0.0393013469119176 no 253 0.0504620252497785 430 3101130
SGTC_1322 1348-1070 12 µM 1.63805943762044 0.0395092806765451 no 254 0.0507046477043261 271 6758089
SGTC_464 bw-b 70c 158 µM 1.63458534619692 0.0398208668865226 no 255 0.0510680008041417 398 5353454
SGTC_889 0919-1524 82.7 µM 1.62903667930778 0.0403226592227724 no 256 0.0516526271902256 338 3905452
SGTC_2610 ononetin 44.17 µM 1.62353748338336 0.0408250323476159 no 257 0.0522372786467316 422 259632
SGTC_118 0083-0097 135.343 µM 1.61638050065681 0.0414864432378983 no 258 0.0530060358042871 616 5207356
SGTC_1036 k216-0215 33.5 µM 1.61612744520497 0.0415099873004554 no 259 0.0530333807486046 433 622330
SGTC_2958 9077254 16.72 µM 1.61096433983362 0.0419927264996636 no 260 0.0535937475477967 339 16457351
SGTC_2704 st078022 71.1 µM 1.60888933490717 0.0421880107926457 no 261 0.0538202709698924 349 54697681
SGTC_2712 st079126 47.7 µM 1.60655665734462 0.0424084221003841 no 262 0.0540758284269506 342 3152970
SGTC_2089 5281248 129.67 µM 1.60221263463793 0.0428213643815165 no 263 0.0545542985389194 372 2737878
SGTC_1335 1486-0900 202 µM 1.60088073884552 0.0429486232027353 no 264 0.0547016682250881 411 X1335
SGTC_112 phenothiazine 287.218 µM 1.59324639890345 0.0436839697853244 no 265 0.0555524630266016 366 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1412 3909-8563 178 µM 1.59285298640565 0.0437221371969878 no 266 0.0555965875842044 399 23767530
SGTC_3195 9113082 49.47 µM 1.58881985409027 0.044114970375539 no 267 0.0560505347647195 328 17018038
SGTC_3329 9141233 27.5565 µM 1.58249767744465 0.0447364816449448 no 268 0.0567680010531878 346 4909101 YNL103W MET4
SGTC_376 3970-0862 59.1 µM 1.57954124121514 0.0450295285356277 no 269 0.0571059823614623 389 3135186
SGTC_3269 9137823 49.47 µM 1.57580431521847 0.0454021473497303 no 270 0.057535453809527 350 17682936
SGTC_2078 5212016 200 µM 1.56845977616981 0.0461417158949074 no 271 0.0583869350930524 324 1899708
SGTC_1323 1348-1351 11.2 µM 1.56785247723932 0.0462032993206351 no 272 0.058457782319048 354 6989654
SGTC_3049 9092223 49.47 µM 1.5678374718396 0.0462048217852547 no 273 0.0584595336966022 350 8623917
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.56546920069586 0.0464456146266817 no 274 0.0587364667967719 375 521171
SGTC_2641 levomentholum 100 µM 1.56482190051267 0.0465116035529925 no 275 0.0588123375550221 306 16666
SGTC_198 3454-2873 16.191 µM 1.56201176644985 0.0467989551928784 no 276 0.0591426084840838 380 710957
SGTC_1871 st057448 67.3 µM 1.56020516814736 0.0469844406391396 no 277 0.0593557023607182 403 691747
SGTC_1134 3477-0009 42.5 µM 1.55137032190587 0.0479000306481279 no 278 0.060406481614139 441 3973534
SGTC_993 3909-8757 62.7 µM 1.54853562345168 0.0481968098374246 no 279 0.0607466959003707 346 4288324 YLR208W SEC13
SGTC_1870 st057514 26.5 µM 1.54812925814242 0.0482394746255015 no 280 0.0607955895407457 390 5393161
SGTC_3283 9109332 35.8195 µM 1.54653281668091 0.0484073795515491 no 281 0.060987970446314 306 17027281
SGTC_2797 7859098 81.82 µM 1.5436372009761 0.048713116945887 no 282 0.0613381237801734 410 972681
SGTC_1681 tripelennamine 100 µM 1.53959051994831 0.0491429747239362 no 283 0.0618300988693651 345 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_102 gallobenzophenone 83.616 µM 1.53655968354932 0.049466904626706 no 284 0.0622005858780622 434 70837
SGTC_1222 0366-0074 1.18 µM 1.5361244246405 0.0495135638900614 no 285 0.0622539334823231 407 286520
SGTC_525 k781-2675 26.7 µM 1.5359968878416 0.0495272423430922 no 286 0.0622695718168232 433 3651118 YDL195W SEC31
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.53404489925072 0.0497369716791728 no 287 0.0625093036729098 391 6312947
SGTC_1715 st032160 10.2275 µM 1.53327571468439 0.0498198102607045 no 288 0.0626039678338763 393 5289825
SGTC_2657 nystatin 74.44 µM 1.52911857356983 0.0502694268097932 no 289 0.0631175258336128 407 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2032 5185112 25.99 µM 1.52759474476915 0.050435044632264 no 290 0.0633065936848064 374 5718189
SGTC_1482 3346-2049 8.48 µM 1.52670393565741 0.0505320636915366 no 291 0.063417324162665 393 3826804
SGTC_1527 coumarin 137 µM 1.52406036597014 0.0508208534432824 no 292 0.0637468161174464 393 323 A hepatotoxic, DNA x-linker.
SGTC_1481 3346-2004 36 µM 1.51989277435602 0.051278798124823 no 293 0.0642689633886291 413 2770522
SGTC_879 0831-1030 162 µM 1.51581664544486 0.0517298623090159 no 294 0.0647828609404113 488 1549252
SGTC_1360 1598-0022 39.8 µM 1.5156623487292 0.0517469985300484 no 295 0.064802376378131 496 761525
SGTC_1674 st016616 23.6 µM 1.51526961652536 0.0517906357982461 no 296 0.0648520697155081 419 625830
SGTC_1435 4092-0789 56.7 µM 1.50765004035654 0.052643064447309 no 297 0.0658220591642619 400 2248285
SGTC_317 4495-0002 170 µM 1.50400912260961 0.0530542991112273 no 298 0.0662895089158881 364 15991618
SGTC_1220 1838-0075 193 µM 1.49840307358477 0.0536924677637713 no 299 0.0670142791677613 430 5529645
SGTC_3188 9110789 49.47 µM 1.49086924169677 0.0545596451071129 no 300 0.0679979141127327 434 849217
SGTC_3129 9127257 49.47 µM 1.48916341069758 0.0547575233839239 no 301 0.0682221716136085 380 837894
SGTC_1440 4100-1550 40 µM 1.48754025718667 0.0549463373214227 no 302 0.0684360894837765 353 742806
SGTC_3084 9116877 49.47 µM 1.48526426458369 0.05521195910194 no 303 0.0687369171106396 340 27241325
SGTC_951 1171-0579 82.7 µM 1.48222726658667 0.0555679731508356 no 304 0.0691399168783772 524 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1238 0333-0287 48.8 µM 1.48204261985395 0.0555896767836747 no 305 0.069164477487889 430 7226
SGTC_1417 3966-0327 90.4 µM 1.48117040962363 0.0556922880498458 no 306 0.0692805845897561 470 651118
SGTC_42 0133-0086 60.653 µM 1.47856515411717 0.0559996738422078 no 307 0.0696282857965851 396 162923 Model of phenazepam hydroxylation.
SGTC_1898 st060199 18.6 µM 1.47646487074542 0.0562484525294155 no 308 0.0699095695424997 408 688866
SGTC_2552 juarezic acid 87.02 µM 1.46848108494158 0.0572020919786391 no 309 0.0709867952475779 512 1549512
SGTC_3071 9117417 49.47 µM 1.46211392833258 0.0579717131237496 no 310 0.0718549962779711 343 45595590 YGL055W OLE1
SGTC_1122 capsaicin 818.572 nM 1.45873847884086 0.0583830040301695 no 311 0.072318550533218 435 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_880 0833-0487 87.2 µM 1.45612690813434 0.0587027877121825 no 312 0.07267877014594 444 76075
SGTC_295 k015-0027 31 µM 1.45365827841466 0.0590063309333335 no 313 0.073020535371955 430 3887424
SGTC_1436 4092-1007 8.32 µM 1.44956714458046 0.059512087225747 no 314 0.0735896318281374 416 2881121
SGTC_2606 farnesol 9.78 µM 1.44766306069475 0.0597486305984329 no 315 0.073855652773313 461 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3054 9094397 49.47 µM 1.445976246122 0.0599587974653377 no 316 0.0740919322205005 485 2598354
SGTC_2626 ethyl orsellinate 100 µM 1.44369090820504 0.0602444597478563 no 317 0.0744129700123742 433 75653 A natural product.
SGTC_1698 5-fluorocytosine 1.055 µM 1.44181837788119 0.0604793151154839 no 318 0.0746768084809341 416 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2990 9074105 71.4286 µM 1.44050124415987 0.0606449405902506 no 319 0.0748628191393848 411 6502001
SGTC_2213 7173844 200 µM 1.44039098830864 0.060658820997964 no 320 0.0748784059104487 441 892728
SGTC_3305 9127027 53.8275 µM 1.43380179594459 0.0614928731739513 no 321 0.0758144161713933 456 41905295
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.4327612644081 0.0616253974545474 no 322 0.075963037328198 463 688669
SGTC_3106 9121286 49.47 µM 1.43070685172742 0.061887706498473 no 323 0.0762571243543426 404 15943471
SGTC_2229 7354935 190 µM 1.42975026957702 0.0620101406314321 no 324 0.076394353388271 385 318112
SGTC_1247 0448-0043 5.84 µM 1.42677532811568 0.0623921152094717 no 325 0.0768223324100833 520 3089013 YGL099W LSG1
SGTC_727 3032-0951 202 µM 1.42152215779845 0.0630710857795983 no 326 0.0775825083233252 427 3652836
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.41941812180482 0.0633446403806658 no 327 0.0778885761173273 501 2333 A French combination drug.
SGTC_2743 auranofin 4.32 µM 1.41926223715088 0.0633649442956007 no 328 0.0779112885968294 444 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3310 9130229 44.1445 µM 1.41835122313469 0.0634837048473627 no 329 0.0780441243618521 449 7761258
SGTC_558 k064-0027 21.3 µM 1.41728764963266 0.0636225722768612 no 330 0.0781994222735073 470 5088526
SGTC_1571 st070080 73.4 µM 1.41699550976263 0.0636607574033098 no 331 0.0782421201435239 458 4315245
SGTC_2585 alliin 100 µM 1.41470516786664 0.0639607424285621 no 332 0.0785774792711478 511 87310 A garlic compound which reacts with lipids.
SGTC_2661 dactinomycin 12.96 µM 1.41103393755383 0.0644438855596988 no 333 0.0791173037025837 508 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1995 st072814 61.1 µM 1.41045576378642 0.0645202324503061 no 334 0.0792025747880892 436 5769371
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.40766390395572 0.0648898821479327 no 335 0.0796153075169451 523 2724 A muscle relaxant with antifungal properties.
SGTC_412 gemfibrozil 100 µM 1.40732261319523 0.0649351825081614 no 336 0.0796658734262003 398 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3170 9103054 49.47 µM 1.40607093053133 0.0651015315651116 no 337 0.0798515316882316 434 16432970
SGTC_522 1273-0010 11.6 µM 1.39868972456471 0.0660892301583395 no 338 0.0809530234466001 464 5705015
SGTC_1705 st027868 56.3335 µM 1.39845667597989 0.06612060301612 no 339 0.0809879869557217 444 292948
SGTC_660 4031-1742 102 µM 1.39614969830521 0.0664317896181315 no 340 0.0813347102921339 536 6738706
SGTC_967 1306-0166 352 µM 1.38993844834028 0.0672752574533187 no 341 0.08227378451522 499 4437607
SGTC_630 4356-0227 183 µM 1.38750585575663 0.0676078429962891 no 342 0.0826437833892213 471 779312
SGTC_1206 3978-0017 132 µM 1.38691185353643 0.0676892479979311 no 343 0.0827343214509833 452 3873677
SGTC_2302 7771753 200 µM 1.38191991956409 0.06837636237263 no 344 0.0834981454755628 537 2203047
SGTC_1139 k015-0024 46.9 µM 1.37414654843459 0.0694570263176425 no 345 0.084698095450337 464 2766652
SGTC_941 3237-0776 460 µM 1.37096669376688 0.069902866067381 no 346 0.0851926694438646 469 760008
SGTC_3012 9080433 71.4286 µM 1.37024097350089 0.0700049255445429 no 347 0.0853058459593323 512 17688859
SGTC_1607 st000305 50.6 µM 1.35624678313113 0.0719954516619648 no 348 0.0875103307033753 519 5457690
SGTC_2433 5607874 27.82 µM 1.35617368095348 0.0720059624350482 no 349 0.0875219569656281 508 2252428
SGTC_361 000s-0510 1.45 µM 1.35437125268708 0.0722654913525475 no 350 0.0878089821384366 518 660
SGTC_348 k064-0012 10.7 µM 1.34885345568288 0.0730644476232835 no 351 0.0886920203760812 476 5066323
SGTC_578 3460-0051 92 µM 1.34650304327496 0.0734068245012848 no 352 0.0890701697955437 567 2876744
SGTC_3181 9108277 49.47 µM 1.34428049395221 0.0737317034491494 no 353 0.0894288503914987 490 17097298
SGTC_1866 st057638 64 µM 1.34238295954824 0.0740099424163522 no 354 0.0897359285072012 498 688802
SGTC_692 k241-0027 77.8 µM 1.34087739515253 0.0742312762903019 no 355 0.0899801312752078 497 3600480
SGTC_2341 7987486 176.74 µM 1.3397378188546 0.0743991419073373 no 356 0.0901652988218992 557 1258686
SGTC_1116 jasmonic acid 1.58368 µM 1.33649735863139 0.0748780627196348 no 357 0.0906933816352809 523 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1562 morin hydrate 59.1 µM 1.33637607757308 0.0748960328930176 no 358 0.0907131907181743 500 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1602 st001878 87.6 µM 1.3363452905369 0.0749005951212828 no 359 0.0907182197386376 499 595405 YLR310C CDC25
SGTC_176 1486-1328 72.834 µM 1.33525060238043 0.0750629511265294 no 360 0.0908971700616319 558 22310231
SGTC_2275 7947463 200 µM 1.33432579931297 0.0752003200636305 no 361 0.0910485529843554 481 1225414
SGTC_2744 captopril 92.04 µM 1.32506692862879 0.0765862032603958 no 362 0.0925744769184873 420 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2052 5265182 7.135 µM 1.32119976001743 0.0771707657938066 no 363 0.0932173831631794 541 1239884
SGTC_1067 clotrimazole 1.36 µM 1.3195412439277 0.0774225039362635 no 364 0.0934941155648964 561 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1368 1852-0141 284 µM 1.3159445667923 0.0779705683778198 no 365 0.0940963244447849 523 2838987
SGTC_978 1416-0512 87.4 µM 1.31427572954813 0.0782258647356657 no 366 0.0943767158779419 587 6814003
SGTC_870 0573-2213 57.6 µM 1.3110458653248 0.0787217649322519 no 367 0.0949211342272339 508 3916321
SGTC_75 0159-0059 199.013 µM 1.30904828391827 0.0790296555274708 no 368 0.0952589978557151 526 5377270
SGTC_236 1509-0011 5.31 µM 1.30508443443517 0.0796433095300511 no 369 0.0959320492015517 837 3107280
SGTC_1994 st072947 40.9 µM 1.30423026606913 0.079776016460474 no 370 0.0960775416830383 548 5286565 YDL195W SEC31
SGTC_2999 9069765 71.4286 µM 1.30388826278691 0.0798291982911339 no 371 0.0961358413582164 565 2097066
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.30271544496936 0.0800117762069077 no 372 0.0963359635560248 583 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2266 7929956 200 µM 1.29569584230424 0.0811111553792791 no 373 0.0975401471753423 568 2967153
SGTC_3159 9100096 49.47 µM 1.29223937344051 0.0816566631373129 no 374 0.0981371300961881 536 25236875
SGTC_1166 k206-0078 225 µM 1.29188041077918 0.0817134736033799 no 375 0.0981992813171801 600 5404595
SGTC_273 hydroxyurea 18.1 mM 1.28944763898025 0.0820992765605487 no 376 0.0986212543305778 628 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1255 0566-0045 221 µM 1.28761784829847 0.0823903583301564 no 377 0.0989395116069752 577 2788469
SGTC_2771 fluoxetine 41.05 µM 1.28268758402832 0.0831785282712971 no 378 0.09980077575105 530 3386 A selective serotonin reuptake inhibitor.
SGTC_245 methotrexate 289.6 µM 1.2789075632888 0.0837866457051185 no 379 0.100464804477314 603 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1834 st055981 52.8 µM 1.27772480066593 0.0839776089957928 no 380 0.100673238709878 576 471719 YDL150W RPC53
SGTC_2373 9071805 200 µM 1.27751208074293 0.0840119884010585 no 381 0.100710759058395 562 10149009
SGTC_656 4090-1979 187 µM 1.27657837120895 0.084163017833229 no 382 0.100875570927066 601 22330961
SGTC_3139 9095020 49.47 µM 1.27625303963295 0.0842156887320836 no 383 0.100933042350421 422 25236292
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.26788893664184 0.0855783384835701 no 384 0.102418807756395 592 165521
SGTC_3343 9148379 18.9835 µM 1.26697205148687 0.0857287125319453 no 385 0.102582641750459 574 1955036
SGTC_1478 0453-0656 35.7 µM 1.26166191433357 0.0866034954856204 no 386 0.103535233470602 559 5258496
SGTC_2533 agelasine 13.65 µM 1.26135728341452 0.0866538814871283 no 387 0.103590075627104 608 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1773 st048542 73.5835 µM 1.25448687244087 0.0877960753035805 no 388 0.104832547151882 600 3237138
SGTC_1916 st067606 49.2 µM 1.24625882899548 0.0891787062969271 no 389 0.106334693787084 637 19590279
SGTC_820 1582-0060 59.9 µM 1.24408790694444 0.0895461927649439 no 390 0.106733605643537 601 3848840
SGTC_946 3434-1334 87.4 µM 1.24250893134312 0.0898141830825072 no 391 0.107024423633115 567 4047976
SGTC_385 1494-0393 12.4 µM 1.24184832402779 0.0899264808242164 no 392 0.107146264666714 594 3090647
SGTC_816 0325-0417 81.3 µM 1.23912185047484 0.0903910628025937 no 393 0.107650188091789 558 68101
SGTC_3353 9151644 39.2805 µM 1.23422494417385 0.0912299504933546 no 394 0.108559547466205 612 4909158
SGTC_1615 st002656 86.5 µM 1.2317556668308 0.0916551448024361 no 395 0.109020184259484 596 1584458
SGTC_2829 7992743 58.44 µM 1.23076277223785 0.0918265284022611 no 396 0.109205801436279 608 16462845
SGTC_1382 3002-2117 298 µM 1.22641790999626 0.0925792879901626 no 397 0.1100207248081 638 1497314
SGTC_2967 9089538 49.85 µM 1.2211588610136 0.0934965277338291 no 398 0.111012938522172 634 728216
SGTC_529 4076-0302 30.3 µM 1.21867725907567 0.0939316717087679 no 399 0.111483356271741 601 5816522
SGTC_1610 st001799 48.1 µM 1.21803524376865 0.094044490790405 no 400 0.111605289994803 536 621897
SGTC_3063 1327-0034 4 µM 1.21416745484955 0.0947262799034728 no 401 0.112341892793457 576 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_891 0929-0073 133 µM 1.21381321546723 0.0947889045802255 no 402 0.112409529315779 620 5603632
SGTC_2512 diallyl trisulfide 49.23 µM 1.21186394494455 0.0951340548619868 no 403 0.112782232861922 569 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2003 4023581 200 µM 1.20927201500949 0.0955944309295855 no 404 0.113279179278172 596 16641307
SGTC_2061 5245884 80.95 µM 1.20810890365873 0.0958015537172131 no 405 0.113502687694857 629 573863
SGTC_1943 st076331 65.2 µM 1.20496758523624 0.0963625981210927 no 406 0.114107907833315 631 24208415
SGTC_3019 9081971 49.47 µM 1.20422525638336 0.0964955312320859 no 407 0.114251263332219 648 16451803
SGTC_3173 9105693 49.47 µM 1.2017554789169 0.0969387783384472 no 408 0.114729139673672 643 17096658
SGTC_1402 3909-7673 35.9 µM 1.20051121820579 0.0971626492628259 no 409 0.11497042922281 609 5328014
SGTC_2646 retinol 96.75 µM 1.20033839385602 0.0971937742964678 no 410 0.115003972195018 604 445354 A vitamin A analog and teratogen.
SGTC_3242 9133940 49.47 µM 1.20019394728377 0.0972197942087958 no 411 0.115032012746344 619 17248444
SGTC_323 4013-0906 34.3 µM 1.19959141718397 0.0973283862199608 no 412 0.1151490307583 608 2910086
SGTC_2772 vinpocetine 57.06 µM 1.19917468361307 0.0974035447768074 no 413 0.115230014524564 601 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2469 5655019 90.81 µM 1.1945450493076 0.0982413719511218 no 414 0.116132414851744 658 2788239
SGTC_2678 equilin 100 µM 1.19309546169799 0.0985047865933323 no 415 0.116415994347053 649 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1 0258-0098 57.368 µM 1.18891533221698 0.0992672819353727 no 416 0.117236493062576 541 6790032 YDR047W HEM12
SGTC_1831 st055328 12 µM 1.18737467127374 0.0995493987698801 no 417 0.117539933100447 651 1103068
SGTC_471 1-acyl-paf 4 µM 1.18650139878989 0.0997095672862251 no 418 0.117712174703648 617 16759367
SGTC_474 dl-dihydrosphingosine 5 µM 1.18295815256057 0.100361372429352 no 419 0.11841286638058 643 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2965 9082772 38.63 µM 1.18080344875518 0.1007592627622 no 420 0.118840406862259 674 16459634
SGTC_425 3825-7017 13.1 µM 1.17988108861024 0.10092993812676 no 421 0.119023756204147 689 3397440
SGTC_1507 4075-3230 155 µM 1.1785055949808 0.101184853596151 no 422 0.119297551567372 567 659771
SGTC_2651 TUB2.036 5 µM 1.17806026056424 0.101267486337041 no 423 0.119386291646611 815 15992207 YFL037W TUB2
SGTC_576 1073-0113 22.7 µM 1.17178310857121 0.102437460100925 no 424 0.120642073013919 823 5439563
SGTC_1344 1488-0097 29.1 µM 1.17076196900319 0.102628712058839 no 425 0.120847234274954 629 747966
SGTC_2389 9091542 195.52 µM 1.16859750488241 0.1030349581953 no 426 0.121282917000906 672 3626624 YOL127W RPL25
SGTC_1990 st072050 59.8 µM 1.1685894579032 0.103036470701118 no 427 0.121284538827225 662 17233948
SGTC_2918 7977171 22.06 µM 1.16590763771136 0.103541442867154 no 428 0.121825895317244 629 2236483
SGTC_2986 9022445 71.43 µM 1.16342679390047 0.104010169254339 no 429 0.122328191888192 642 6459286
SGTC_366 0181-0206 4.31 µM 1.16298502073135 0.104093798258538 no 430 0.122417789981219 682 274874
SGTC_2 0422-0095 29 µM 1.16035807791326 0.104592093505512 no 431 0.122951523771976 534 6790840
SGTC_726 3448-4391 34.2 µM 1.15692296430266 0.105246291674483 no 432 0.123651917737844 703 1356692
SGTC_1735 st034310 56.75 µM 1.15690620896 0.105249489875097 no 433 0.123655340859703 656 871153
SGTC_1277 0873-0036 22 µM 1.15609881557705 0.105403685616039 no 434 0.123820370229758 704 5965735
SGTC_1343 1487-0095 224 µM 1.15491057186994 0.105630913140668 no 435 0.124063524854663 639 4560101 YGL055W OLE1
SGTC_1669 st015249 58.4 µM 1.14540765666335 0.107460905284843 no 436 0.126020164045588 665 722793
SGTC_2063 5246145 200 µM 1.13903124505952 0.108701563853363 no 437 0.127345061204554 694 711240
SGTC_3108 9121785 49.47 µM 1.13680900703454 0.109136356046246 no 438 0.127809068607744 655 17140271
SGTC_3186 9110464 49.47 µM 1.13395714524203 0.109696166483944 no 439 0.128406262310196 670 17018021
SGTC_2664 lyso-paf C-16 73.48 µM 1.1338198570734 0.109723167580969 no 440 0.128435059909836 709 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_133 0724-0033 378.92 µM 1.13380735325594 0.109725627001427 no 441 0.128437682936368 629 280309
SGTC_2162 5663267 200 µM 1.12920566233093 0.110633438998862 no 442 0.129405542824224 721 6456493
SGTC_990 3985-0011 41.3 µM 1.12764117450648 0.110943300677025 no 443 0.129735745148263 623 5399565 YGL099W LSG1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.1274291751184 0.110985336950471 no 444 0.129780534797564 766 551469
SGTC_1742 st038235 28.8875 µM 1.12561802258035 0.111344926225947 no 445 0.130163618104516 694 564103 YBR002C RER2
SGTC_784 4579-0127 173 µM 1.12371502037042 0.111723649145549 no 446 0.130566971118239 725 1948547
SGTC_3254 9136651 49.47 µM 1.12332493273452 0.111801395476987 no 447 0.130649759217381 709 16454030
SGTC_1210 3013-0140 750 nM 1.12295647241701 0.111874866910194 no 448 0.130727990685225 736 905973
SGTC_2860 9025725 38.96 µM 1.12165031796596 0.112135593820712 no 449 0.131005574131514 643 40546248
SGTC_2808 7946468 45.46 µM 1.1207471311925 0.11231613650684 no 450 0.131197757037551 720 2970879
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.12054312868579 0.112356944366085 no 451 0.131241192273294 690 5377381
SGTC_1384 3089-0840 101 µM 1.11991410081555 0.112482839319611 no 452 0.131375184389089 648 1069836
SGTC_1094 duloxetine 25.4 µM 1.11708082707713 0.113051145793588 no 453 0.131979883733078 676 60834 A selective serotonin reuptake inhibitor.
SGTC_1588 farnesol 29.9 µM 1.11575799530296 0.113317183861279 no 454 0.132262869141263 707 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1260 0700-1617 7.75 µM 1.11547373104957 0.11337441121482 no 455 0.132323734632377 704 2853078
SGTC_222 nsc-310342 10.666 µM 1.11532328181482 0.113404707611062 no 456 0.132355956014384 586 432556
SGTC_2180 6301957 200 µM 1.11052574042063 0.114373831700001 no 457 0.133386271229008 706 845462
SGTC_1148 3909-7663 27.7 µM 1.10682826714959 0.115124750214875 no 458 0.134184092190789 720 4084526
SGTC_3326 9140064 16.379 µM 1.10585228462015 0.115323545609535 no 459 0.134395230150802 685 1868434
SGTC_443 clozapine 122 µM 1.10519018370714 0.115458546087595 no 460 0.134538594724479 599 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2775 cyproheptadine 69.59 µM 1.10459676218578 0.11557963843152 no 461 0.134667177344082 710 2913 A selective serotonin reuptake inhibitor.
SGTC_2557 derrustone 83.84 µM 1.1013038416116 0.116253224384503 no 462 0.135382219887976 715 629853 An antioxidant.
SGTC_2902 5787006 60.46 µM 1.10118226437425 0.116278146921799 no 463 0.135408669542459 686 591003
SGTC_202 3594-0513 34.79 µM 1.1007957451672 0.116357406012223 no 464 0.135492781995937 678 708429
SGTC_2933 9026794 32.47 µM 1.09983020509675 0.116555565757452 no 465 0.135703054590152 728 17586027
SGTC_757 1066-0008 322 µM 1.09891257454085 0.116744114643172 no 466 0.135903100644705 752 6842497
SGTC_3320 9137005 35.139 µM 1.09824661767565 0.116881086567379 no 467 0.136048407508407 674 4908713
SGTC_2008 4012253 172 µM 1.09616213163069 0.117310553266786 no 468 0.136503914190528 722 603940
SGTC_403 arphamenine a 50 µM 1.09314389878171 0.117934378689051 no 469 0.137165312153029 702 5487158 An arginine aminopeptidase inhibitor.
SGTC_333 3486-0131 40.1 µM 1.09284587896756 0.117996102175909 no 470 0.137230737027432 744 6744690
SGTC_487 nimodipine 119 µM 1.09158287461749 0.118257939189028 no 471 0.137508243407391 602 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2399 5884133 200 µM 1.09117821754454 0.11834191662544 no 472 0.137597235337694 685 722445
SGTC_777 1315-0167 517 µM 1.08950737312202 0.118689109036414 no 473 0.137965102611071 666 4221767
SGTC_2785 7756463 72.73 µM 1.08919124454245 0.118754879719004 no 474 0.138034779559495 692 2201551
SGTC_3096 9117468 49.47 µM 1.08591480573087 0.119438060698059 no 475 0.138758342936968 599 41316311
SGTC_1430 4049-0248 69.1 µM 1.08466872227795 0.119698612097683 no 476 0.139034202814188 797 22774488
SGTC_1213 1315-0166 115 µM 1.0846015782927 0.119712663027038 no 477 0.139049077846285 608 768401
SGTC_2874 9043904 71.43 µM 1.08218570804712 0.120218995688719 no 478 0.139585008870878 612 4463428
SGTC_2324 6149169 200 µM 1.08170241197431 0.120320468650351 no 479 0.139692390535495 680 2888231
SGTC_2784 7567673 72.73 µM 1.08139127169095 0.120385827656897 no 480 0.139761551289586 749 3471247
SGTC_3105 9121040 49.47 µM 1.08138231241474 0.120387710038095 no 481 0.139763543116397 487 41448907
SGTC_743 1275-0778 158 µM 1.08008423953624 0.120660659680297 no 482 0.140052334714496 764 2849257 YMR203W TOM40
SGTC_1944 st076371 56.9 µM 1.0793434780676 0.120816616905245 no 483 0.140217318818675 710 24208455
SGTC_1637 st007924 17.4 µM 1.07518938829218 0.121693832489518 no 484 0.141144972721959 719 683336
SGTC_1483 3453-0561 55.9 µM 1.07341063223007 0.122070816131075 no 485 0.141543458093423 757 4546991
SGTC_2852 9023854 51.95 µM 1.07296004841598 0.122166441407203 no 486 0.141644520901661 733 19798528
SGTC_3244 9134489 49.47 µM 1.07259162244041 0.122244669787319 no 487 0.141727192596651 713 16584271
SGTC_2845 9003024 42.97 µM 1.07136717201261 0.122504911605141 no 488 0.14200218375729 733 2990173
SGTC_594 1487-1584 10.8 µM 1.07066127583683 0.122655117654107 no 489 0.142160880309612 722 5013332
SGTC_1076 itraconazole 331 nM 1.06958805430394 0.12288373348182 no 490 0.142402387261005 752 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_148 3253-0744 288.01 µM 1.06786691448889 0.12325099127671 no 491 0.14279027435402 705 6893655
SGTC_1494 4358-1428 177 µM 1.06575676347366 0.123702305147517 no 492 0.143266805239145 768 1564571
SGTC_169 k015-0017 16.025 µM 1.06328867526677 0.12423164033025 no 493 0.14382552963181 667 1840002
SGTC_1515 3460-0031 42.1 µM 1.06285957800945 0.124323831004469 no 494 0.143922818226925 673 2876596
SGTC_1415 3966-0071 78.1 µM 1.06186447517709 0.124537810937988 no 495 0.144148607245079 732 2893185
SGTC_3069 9117009 49.47 µM 1.0614826556888 0.12461998303311 no 496 0.144235305524725 600 41904981
SGTC_603 3794-0023 45.9 µM 1.05949164859223 0.125049085490115 no 497 0.14468796532738 745 3802260
SGTC_422 cantharidin 155 µM 1.05669766933175 0.125652983309926 no 498 0.145324794515398 738 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2075 5212009 200 µM 1.05526459113368 0.125963520729973 no 499 0.145652165290956 668 780898
SGTC_974 1326-0144 138 µM 1.05288631605675 0.126480055527783 no 500 0.146196549197408 771 5411856
SGTC_87 0100-0052 35.5 µM 1.05182631492736 0.12671075069538 no 501 0.146439621713028 959 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_48 0382-0018 55 µM 1.05127094644908 0.126831736175057 no 502 0.146567083425489 720 762596
SGTC_1169 aniline yellow 25.8 µM 1.04690524728455 0.127785592768429 no 503 0.147571640759488 728 6051 A DNA damaging agent.
SGTC_2921 7974240 10.71 µM 1.04288318676765 0.128668770373189 no 504 0.148501198739615 741 2979074 YDR527W RBA50
SGTC_2322 7413319 38.22 µM 1.04086381153201 0.129113785038148 no 505 0.148969379630619 852 1840400
SGTC_3114 9122766 49.47 µM 1.03816270349802 0.129710701453806 no 506 0.149597156585368 696 17176985
SGTC_994 3910-0338 138 µM 1.03373039687852 0.130694330447742 no 507 0.150631109284409 791 3479481
SGTC_2531 methyl deoxycholate 70.07 µM 1.02876723233234 0.131801874801171 no 508 0.151794534031669 711 16667744 Haematoxylin.
SGTC_600 1495-0418 41.6 µM 1.02284297575241 0.13313234561144 no 509 0.15319104742208 757 5377768
SGTC_970 1315-0089 19.5 µM 1.02214710081776 0.133289229846169 no 510 0.153355641674415 735 6811083 YLR033W RSC58
SGTC_3015 9080845 49.47 µM 1.02139065795095 0.133459913289257 no 511 0.153534694818075 836 5296973
SGTC_3158 9100007 49.47 µM 1.01617856977071 0.134640052850713 no 512 0.154772179754517 705 19297233
SGTC_2199 6590217 200 µM 1.01471416371196 0.134972913825641 no 513 0.155121050266076 718 703109
SGTC_2246 7293507 91.5585 µM 1.01280714168325 0.135407227336606 no 514 0.155576144405576 821 887656
SGTC_2975 9084847 53.72 µM 1.01177885822153 0.135641810131167 no 515 0.155821900377119 804 27211724
SGTC_116 0155-0182 31.788 µM 1.0109879727527 0.13582242451257 no 516 0.156011093143878 884 771486
SGTC_2705 st078069 42.8 µM 1.0109287049203 0.135835966127934 no 517 0.156025277076082 729 1530061
SGTC_1812 st052057 4.327 µM 1.00935470165177 0.136195935422943 no 518 0.156402277323635 814 3645418
SGTC_309 k408-0051 1.48 µM 1.00849407059974 0.136393034687792 no 519 0.156608666410911 847 3640463
SGTC_2298 7976326 193.81 µM 1.00841736670127 0.136410610661146 no 520 0.156627069573565 718 2235818
SGTC_1756 st041558 35.5 µM 1.00824441425412 0.136450246764826 no 521 0.156668570367549 878 3955792
SGTC_85 0868-0259 160.055 µM 1.00306814138003 0.137640157849314 no 522 0.157913992431701 765 83173
SGTC_1064 honokiol 6.76 µM 1.00268997387898 0.137727366983338 no 523 0.158005234447146 811 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2943 9068529 45.32 µM 1.0023321980587 0.137809908300551 no 524 0.158091588334141 876 3270634
SGTC_1196 1588-0294 184 µM 1.00146820828959 0.138009375768063 no 525 0.158300251308137 752 6144269
SGTC_814 3342-0569 96 µM 1.00015465537189 0.138313010016076 no 526 0.158617834752833 811 4346283
SGTC_1372 2752-0194 270 µM 0.998822715349429 0.138621359181172 no 527 0.158940290036891 752 823334
SGTC_3179 9107801 49.47 µM 0.995565892292804 0.13937729744839 no 528 0.159730556909014 801 4818259
SGTC_66 0109-0187 42.4 µM 0.992957351724239 0.139984782518299 no 529 0.160365369327849 740 759417
SGTC_468 gf-109203x 121 µM 0.992088710018123 0.140187473248808 no 530 0.160577126714595 676 2396 A protein kinase C inhibitor.
SGTC_74 000s-0487 160.283 µM 0.99082819530238 0.140481958867496 no 531 0.16088473954715 860 677548
SGTC_1972 st070201 17.4 µM 0.990316511585871 0.140601619868847 no 532 0.161009719252367 820 2829099
SGTC_3270 9137563 49.47 µM 0.989778354280978 0.140727546537459 no 533 0.161141233528901 766 17015724
SGTC_1819 st053448 58.6 µM 0.989503079111462 0.140791989409747 no 534 0.161208532053016 811 2857616
SGTC_539 4859-0462 2.54 µM 0.988012582797655 0.141141267458145 no 535 0.161573242914952 832 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_272 doxorubicin 8.13 µM 0.985371407141922 0.141761633892578 no 536 0.162220834568732 847 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_998 3996-0085 177 µM 0.984576386780544 0.141948731477363 no 537 0.162416096599346 893 715391
SGTC_1345 1488-0192 31.4 µM 0.983634090075738 0.142170705028918 no 538 0.16264772864528 855 658348
SGTC_2423 st077119 87.2 µM 0.981431861746947 0.142690391919201 no 539 0.163189910211776 792 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2748 diazoxide 86.69 µM 0.978596131764508 0.143361463478287 no 540 0.163889785674647 767 3019 A potassium channel activatior.
SGTC_1936 st074407 74.3 µM 0.978335921559432 0.143423148434925 no 541 0.163954104564787 851 809813
SGTC_3138 9097216 49.47 µM 0.976676458204694 0.143816959311088 no 542 0.164364676780542 892 25237486
SGTC_2435 5706476 10.6 µM 0.97501917718193 0.144210979735224 no 543 0.164775373724572 877 5725375
SGTC_952 1185-0122 232 µM 0.974116955174989 0.144425789689412 no 544 0.164999235911255 808 678600
SGTC_758 0868-0029 16 µM 0.97370831322799 0.1445231541252 no 545 0.16510069421305 844 762687
SGTC_147 4466-0538 29.23 µM 0.972923905823926 0.144710173627751 no 546 0.165295561329923 842 6742687 YHR072W ERG7
SGTC_1751 st044839 27.194 µM 0.97092255418087 0.145188076879189 no 547 0.16579342293047 827 5291326
SGTC_2846 9008642 19.48 µM 0.968052559847984 0.145875255108257 no 548 0.166509060405334 762 2992898
SGTC_1947 st076332 61.6 µM 0.96284092492092 0.147128685159138 no 549 0.167813679733757 806 24208416
SGTC_276 colchicine 750 µM 0.962820059480706 0.147133717893993 no 550 0.167818916134601 861 2833 A microtubule depolymerizer.
SGTC_2027 5150920 200 µM 0.962584063463896 0.147190648062773 no 551 0.167878149131343 824 786715
SGTC_1686 st019653 115.5 µM 0.959424599527092 0.147954239062911 no 552 0.168672443730687 864 97252
SGTC_984 1492-0255 2.91 µM 0.959418468756712 0.147955723343357 no 553 0.168673987361083 798 1585198
SGTC_1926 methyl fluorone black 53.6 µM 0.954971118628611 0.149035068513386 no 554 0.169796151292876 771 72721 Reacts with homocysteine.
SGTC_13 0199-0087 65 µM 0.954225250971771 0.149216599854916 no 555 0.169984817772529 886 4589825
SGTC_2753 fluvastatin 17.09 µM 0.951923210952137 0.149777807535276 no 556 0.170567963534451 853 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_802 4112-3352 742 µM 0.950552360823339 0.150112671136917 no 557 0.17091583085874 907 704594
SGTC_920 mycophenolic acid 780.421 nM 0.948992649498584 0.150494275206733 no 558 0.171312175280824 816 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3076 9116187 49.47 µM 0.94867695896962 0.150571591649146 no 559 0.1713924680941 817 27241210
SGTC_1486 3970-0793 4.53 µM 0.945312997191776 0.151397109536202 no 560 0.172249552439216 884 2844330
SGTC_2502 avocadyne acetate 18.59 µM 0.943729834811953 0.151786657952222 no 561 0.172653861963881 952 3952079
SGTC_2037 5169046 200 µM 0.936512657067554 0.153570928525083 no 562 0.174504649453323 848 5718022
SGTC_18 0111-0177 500 nM 0.935807503097313 0.153746002399724 no 563 0.174686153834647 966 721752
SGTC_695 3505-6186 243 µM 0.935509738705397 0.153819970262563 no 564 0.174762833417766 863 1819379
SGTC_729 4092-0585 94.1 µM 0.935480254310859 0.153827295783243 no 565 0.174770427331844 814 2169061
SGTC_1570 verbenone 133 µM 0.930565391015283 0.15505164157521 no 566 0.176039211992495 897 29025 A natural terpanoid with antifungal properties.
SGTC_1291 0993-0025 5.79 µM 0.930400362075377 0.155092863425525 no 567 0.176081915588265 906 4353356
SGTC_1910 st062352 60.4 µM 0.930005620215412 0.155191493603216 no 568 0.176184087284622 878 2245730
SGTC_2447 5741742 33.78 µM 0.929943283720304 0.155207072780945 no 569 0.176200225373982 894 1776504
SGTC_2370 9071495 200 µM 0.92667797586897 0.156024584044346 no 570 0.177046877941157 822 21791103
SGTC_423 5-fluorouracil 457 µM 0.926478264104963 0.156074676346304 no 571 0.177098743922376 842 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2931 9014674 55.67 µM 0.922232766995234 0.157142051775232 no 572 0.178203587444033 870 2996810
SGTC_1956 st077085 54 µM 0.92199323266503 0.157202416673897 no 573 0.178266052795215 901 24208685
SGTC_1386 3228-0095 33.8 µM 0.919389533116156 0.157859556921684 no 574 0.17894593103878 861 870181
SGTC_2219 9098279 200 µM 0.918928307508338 0.157976152139402 no 575 0.17906653621648 883 902349
SGTC_330 1488-0319 80.1 µM 0.91828662620125 0.158138459561254 no 576 0.179234413523807 875 6846614
SGTC_801 0866-0028 10.1 µM 0.91160421471328 0.159835217006831 no 577 0.180988551450084 914 6849771
SGTC_440 fluspirilene 35.1 µM 0.908777165606592 0.160556615923151 no 578 0.181733881091028 895 3396 An atypical antipsychotic.
SGTC_453 enantio-paf c16 10 µM 0.906310937570252 0.16118767578954 no 579 0.182385648961023 967 13871343 A lipid and platelet activating factor
SGTC_3281 9140613 49.47 µM 0.906162746230048 0.161225646546047 no 580 0.182424859012839 827 16013766
SGTC_1086 cerivastatin 2.18 µM 0.906079347595136 0.161247018169301 no 581 0.182446927832389 892 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3040 9091894 49.47 µM 0.904436773786368 0.161668318566653 no 582 0.182881923057588 832 25236966
SGTC_887 0885-0007 9.62 µM 0.902269796739615 0.162225218697653 no 583 0.183456782901351 920 5719458
SGTC_1314 1222-0010 41.1 µM 0.899860936528017 0.162845745498926 no 584 0.184097130401009 912 3526027
SGTC_2127 5253358 187.912 µM 0.899792175825221 0.16286348101034 no 585 0.184115429465771 813 20612
SGTC_2237 6667747 47.222 µM 0.898719918967368 0.16314021170925 no 586 0.184400932214658 853 729940 YDL015C TSC13
SGTC_2491 paeonol 100 µM 0.89816874182692 0.16328257971162 no 587 0.184547797626758 892 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2837 9008476 45.46 µM 0.897120637700736 0.163553525626191 no 588 0.184827273699164 908 2992805
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.895212286856534 0.164047603626091 no 589 0.185336808925129 848 6857784
SGTC_3146 9095609 49.47 µM 0.894870833071559 0.164136109095296 no 590 0.185428069977696 900 17173999
SGTC_914 3820-6779 408 µM 0.89197552994842 0.16488782157017 no 591 0.186203024228163 925 2893481
SGTC_2476 5806916 10.51 µM 0.88886684004097 0.165697414175487 no 592 0.187037324273991 885 2870194
SGTC_780 0109-0199 192 µM 0.887427908598904 0.166073022176857 no 593 0.187424281682837 969 610414
SGTC_1240 0356-0016 42.1 µM 0.881641538949835 0.167589002253022 no 594 0.188985342210587 905 4305613
SGTC_478 N-arachidonylglycine 10 µM 0.881207434200209 0.167703092377575 no 595 0.18910277812386 835 5283389
SGTC_2929 9013348 24.6 µM 0.881068896837798 0.167739512882701 no 596 0.189140265314332 894 2995952
SGTC_1049 3226-0134 66 µM 0.880983406217258 0.167761990310925 no 597 0.189163400730145 953 5702385
SGTC_2477 5967686 25.23 µM 0.880345537836001 0.167929761631108 no 598 0.189336075256146 915 776118
SGTC_1853 st056710 91.2 µM 0.880280412158505 0.167946896977074 no 599 0.189353710597195 995 269167
SGTC_2481 5478948 45.16 µM 0.879904558475 0.168045810572998 no 600 0.189455507532861 880 77792
SGTC_699 0375-0592 111 µM 0.877644972223066 0.168641256965342 no 601 0.190068207812035 982 762578
SGTC_1766 st045414 44.774 µM 0.876574699474575 0.168923768073753 no 602 0.190358843172268 1001 253960
SGTC_2286 7945697 125 µM 0.875931256124617 0.169093758779028 no 603 0.19053370319979 925 1245733
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.875182632211761 0.169291675248173 no 604 0.190737270816492 997 688664
SGTC_1293 1000-1278 195 µM 0.869491029635324 0.170801245378326 no 605 0.192289306210988 960 678847
SGTC_638 3970-0837 4.09 µM 0.866470958821086 0.171605738871276 no 606 0.193115972776744 933 4118451 YLR208W SEC13
SGTC_1672 st016598 6.51 µM 0.86546318146032 0.171874730803529 no 607 0.193392307950032 903 4665860 YNL267W PIK1
SGTC_665 3914-0008 307 µM 0.864171412832762 0.17221991807678 no 608 0.193746866877098 937 1069549
SGTC_3218 9131285 49.47 µM 0.863946086797205 0.172280175131658 no 609 0.193808753936725 1005 17156417
SGTC_1332 1480-0653 17.5 µM 0.863680770373957 0.172351143723386 no 610 0.193881640026619 962 5749438
SGTC_2923 7992654 58.14 µM 0.862033621874232 0.172792151109953 no 611 0.194334508191939 932 2985126
SGTC_1618 st003135 44.5 µM 0.859333543019004 0.173516624280584 no 612 0.195078261593748 951 1270615
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.859112403639562 0.173576044942598 no 613 0.195139252366493 977 641818 YHR062C RPP1
SGTC_1070 indatraline 8.81 µM 0.854074655160928 0.174933205866716 no 614 0.19653181295126 948 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1321 1326-2144 215 µM 0.853794306246662 0.175008928660663 no 615 0.196609484915139 986 3513030
SGTC_3200 9114385 49.47 µM 0.853170558462525 0.175177478760971 no 616 0.19678236382835 917 17018030 YLR208W SEC13
SGTC_1811 st050069 61.5 µM 0.852935147805 0.175241118548887 no 617 0.196847634535639 971 3877702
SGTC_1378 2093-0007 380 nM 0.85056026880044 0.175883951780997 no 618 0.19750683395166 941 3618014
SGTC_84 0443-0269 128.823 µM 0.847369277218249 0.176750038874809 no 619 0.198394661696998 991 6150058
SGTC_1178 0988-0033 191 µM 0.844913261996138 0.177418474326909 no 620 0.199079634653904 970 5392207
SGTC_3107 9121808 49.47 µM 0.843232908471355 0.177876721900221 no 621 0.199549098470646 962 662681
SGTC_1073 triclabendazole 3.09 µM 0.841192479323661 0.178434167957063 no 622 0.200120056519141 1019 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2556 citropten 84.59 µM 0.83802276496287 0.179302315285318 no 623 0.201008959075846 1044 2775 A potential DNA crosslinker.
SGTC_3289 9119912 71.43 µM 0.83647762635662 0.179726471827458 no 624 0.201443129174664 973 17014829
SGTC_2687 chenodiol 100 µM 0.834051239819689 0.180393811107517 no 625 0.202126055144379 944 5702181 A cholesterol synthesis inhibitor.
SGTC_3330 9141424 71.43 µM 0.833433673372283 0.180563910884255 no 626 0.202300095097733 1028 27261020
SGTC_1962 st076595 64.5 µM 0.831807959101629 0.181012171204293 no 627 0.202758675332563 998 279619
SGTC_1901 st060216 58.6 µM 0.831605527384543 0.181068036743518 no 628 0.202815820569466 1039 688792
SGTC_1484 3473-2379 286 µM 0.830954017053672 0.181247908842131 no 629 0.202999803260915 1171 671917
SGTC_954 1189-0853 2.85 µM 0.830524547034123 0.181366540161007 no 630 0.203121137558115 1053 2828194
SGTC_2034 5197015 53.07 µM 0.829893248985709 0.181541010112157 no 631 0.203299571087677 981 780676
SGTC_1923 st058458 19.1 µM 0.828535697487119 0.181916548237128 no 632 0.20368359357397 1058 3534982
SGTC_1603 st002045 67.8 µM 0.827950725983811 0.182078517992598 no 633 0.203849202838758 1017 5887985
SGTC_1785 bathophenanthroline 24 µM 0.827303078376941 0.182257946941216 no 634 0.204032649701378 953 72812 An iron chelator.
SGTC_1347 1493-0251 600 nM 0.82683056270122 0.182388925775548 no 635 0.204166552295161 1046 3986378
SGTC_1101 ebselen 5.29 µM 0.826159696513395 0.182574987307458 no 636 0.204356753798921 1084 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1783 st039459 87.517 µM 0.825262275649084 0.1828240679686 no 637 0.204611352117734 1060 729761
SGTC_1100 amiodarone 5.07 µM 0.821774781613626 0.183794040142084 no 638 0.20560254449123 1052 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1056 3448-1962 115 µM 0.821711547302873 0.183811656955567 no 639 0.205620542796433 960 715507
SGTC_191 3914-0123 66.505 µM 0.820907385600169 0.184035784761429 no 640 0.205849511930768 885 3144412
SGTC_2662 daunorubicin 22.37 µM 0.820533958495368 0.18413992040776 no 641 0.205955889322626 971 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2191 5911152 200 µM 0.820165335807523 0.184242752237105 no 642 0.20606093006399 1010 2875902
SGTC_432 NS 1619 61.3 µM 0.817094124275659 0.185100893093373 no 643 0.206937320257572 940 4552 A K+/calcium channel activator.
SGTC_782 0083-0095 30.5 µM 0.817042812356452 0.185115251439675 no 644 0.20695198115769 1071 3591729 An indicator and reagent.
SGTC_1143 3454-2408 5.08 µM 0.816674111957073 0.185218443291103 no 645 0.207057344731807 981 X1143
SGTC_1981 st071826 47 µM 0.815134720456215 0.185649673948679 no 646 0.207497599647767 960 11838600
SGTC_3060 1327-0027 12.5 µM 0.814627128609958 0.185792002412391 no 647 0.207642888475268 980 16000455 YPR107C YTH1
SGTC_3339 9145883 14.936 µM 0.812362815211219 0.186427738613138 no 648 0.208291738249107 955 2030670
SGTC_214 4373-3496 70 µM 0.811188579415685 0.186757950907017 no 649 0.208628691562232 1150 3779166
SGTC_2873 9040596 71.43 µM 0.810923240338206 0.186832618257144 no 650 0.208704876529787 1040 6463863
SGTC_316 k060-0003 58.6 µM 0.809619740973568 0.18719969581931 no 651 0.20907937931652 1008 6152314
SGTC_2105 5350118 200 µM 0.808977352660381 0.187380762294795 no 652 0.209264086607652 1032 2133313
SGTC_720 r052-1644 49.9 µM 0.806664087359335 0.188033686116791 no 653 0.209930019955432 946 1422863 YOR257W CDC31
SGTC_1721 st082152 9.2685 µM 0.803931917875172 0.188806652919291 no 654 0.21071814768997 1011 5296051
SGTC_1363 1636-0063 10.4 µM 0.80301444343176 0.189066657112768 no 655 0.210983193214868 1076 6072185
SGTC_39 0986-0283 58.349 µM 0.801262592179149 0.189563728545943 no 656 0.211489821052883 1084 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_899 1083-0020 478 µM 0.800270401031821 0.189845609828733 no 657 0.211777074161482 1030 767123
SGTC_72 0744-0168 198.391 µM 0.798923637570271 0.190228637119389 no 658 0.212167345914857 989 677577
SGTC_2187 6125751 200 µM 0.798439464702074 0.190366454616461 no 659 0.212307754601709 1018 874498
SGTC_1441 4106-0040 13 µM 0.796460217342321 0.190930475399387 no 660 0.212882294884588 1055 2904180
SGTC_101 0490-5701 117.494 µM 0.795502972982104 0.191203626136073 no 661 0.213160491135057 988 4661669
SGTC_2114 5491910 81.25 µM 0.793065815844398 0.191900152320072 no 662 0.213869738995732 1051 2849228
SGTC_2107 5363541 170.161 µM 0.792597385085476 0.192034205006392 no 663 0.214006216362232 1060 244052
SGTC_117 lucigenin 22.078 µM 0.792297132023456 0.192120159744777 no 664 0.214093721787608 1096 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1519 esterone 74 µM 0.792131405998023 0.192167612928956 no 665 0.21414202971706 1035 698 A steroid.
SGTC_1685 st024049 53.0905 µM 0.790760088244631 0.19256054447256 no 666 0.214542002168173 1021 1941139
SGTC_3252 9135871 49.47 µM 0.789959555007432 0.192790152712527 no 667 0.214775694443004 1083 17682838
SGTC_1747 st037496 66.6 µM 0.788204328102866 0.193294170451379 no 668 0.215288598949676 1059 723305
SGTC_2769 toremifene 3.73 µM 0.787806747702716 0.193408448248402 no 669 0.215404876763969 1030 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2711 st079103 59.1 µM 0.787341151514195 0.193542328428753 no 670 0.215541093029511 1052 54693780
SGTC_2265 7929201 200 µM 0.787032737576365 0.193631042643802 no 671 0.215631351067526 1105 1265108
SGTC_297 0986-0032 24 µM 0.786684611464289 0.193731209717248 no 672 0.215733257287994 1044 2847425
SGTC_1189 1431-2119 7.28 µM 0.782516608460605 0.1949329301123 no 673 0.216955514294683 1083 3107275
SGTC_2881 9058953 51.95 µM 0.782284919021245 0.194999863627924 no 674 0.217023573897947 1088 17122249
SGTC_1899 st063254 59.6 µM 0.78037474705851 0.195552231742845 no 675 0.21758516376155 990 3093813
SGTC_2861 9024595 19.48 µM 0.776173048599019 0.196770583986888 no 676 0.218823408552134 1022 16482810
SGTC_1996 st072960 66.8 µM 0.775824305880707 0.196871913919645 no 677 0.218926365296742 1092 1719405
SGTC_45 0kpi-0036 14.9 µM 0.775169425726796 0.197062279833617 no 678 0.219119776017198 1046 2795021
SGTC_3345 9148410 3.559 µM 0.774371879935259 0.19729426735148 no 679 0.21935545388975 1054 4903596
SGTC_321 4534-3890 65.3 µM 0.773585115895416 0.197523280496605 no 680 0.219588088372907 1104 699746
SGTC_1301 naphtanilide LB 4.81 µM 0.773534537090706 0.197538008591278 no 681 0.219603048622755 1129 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1381 2324-0066 62.1 µM 0.773455565682537 0.197561005685169 no 682 0.219626408035878 1032 10885928
SGTC_2161 5662504 8.5105 µM 0.770248186438567 0.198496386903546 no 683 0.22057634258066 1026 2859334
SGTC_1976 st070609 63.5 µM 0.769581020874217 0.198691290285264 no 684 0.220774233397462 1069 682556
SGTC_785 1270-0111 65.3 µM 0.768413896895444 0.199032527142514 no 685 0.221120663391749 1106 6741994
SGTC_1565 sinapyl alcohol 95.1 µM 0.76821355672 0.199091136916239 no 686 0.22118016035501 1090 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2033 5192550 145 µM 0.76648892780432 0.199596109210988 no 687 0.221692718745054 1089 182073
SGTC_462 ag-879 158 µM 0.766338312725688 0.199640245954519 no 688 0.221737513631085 1122 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_540 1187-0821 17.3 µM 0.765826536323795 0.199790262488452 no 689 0.221889761230078 1048 847520
SGTC_69 0096-0274 206.684 µM 0.765613391752436 0.199852761351582 no 690 0.221953186896241 1242 6741392
SGTC_477 mead ethanolamide 10 µM 0.764005863997653 0.20032450391174 no 691 0.222431874050034 958 16061185
SGTC_939 1165-0479 45.3 µM 0.763596709881547 0.200444680357555 no 692 0.222553805275243 1070 1377347
SGTC_3059 1327-0034 3 µM 0.762473626717238 0.200774774007366 no 693 0.222888688911923 1059 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_504 lovastatin 124 µM 0.76138226320428 0.201095857068271 no 694 0.223214389159397 1084 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3034 9090421 49.47 µM 0.760605641914134 0.201324529274103 no 695 0.223446324444628 1052 17173761
SGTC_723 4182-0001 115 µM 0.759399708197177 0.201679919132331 no 696 0.223806744013846 1071 744821 YLR208W SEC13
SGTC_2639 lactacystin 53 µM 0.758087213321799 0.20206713939748 no 697 0.224199386976396 1095 3870 A proteasome inhibitor.
SGTC_407 eburnamonine 100 µM 0.757313633328429 0.202295573944959 no 698 0.224430992494749 1038 3195
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.756668602135723 0.202486166675748 no 699 0.224624214991854 1173 23665772 A membrane-active detergent.
SGTC_1366 1683-0113 21.9 µM 0.755386956512275 0.202865183599734 no 700 0.225008418588016 1120 708623
SGTC_3354 9151612 71.43 µM 0.754394906890556 0.203158849998446 no 701 0.225306064456098 1119 27261949
SGTC_2691 st077356 60.2 µM 0.754306749464194 0.203184958620073 no 702 0.225332525220119 1122 2839272
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.754205401166482 0.203214976312589 no 703 0.225362947445205 1048 15053
SGTC_1893 st059353 36.1 µM 0.751431798942742 0.20403749852849 no 704 0.22619641568909 1084 3112488
SGTC_1925 st057770 10.1 µM 0.750326474771149 0.204365838512833 no 705 0.226529050639747 1074 5989122
SGTC_3215 9129942 49.47 µM 0.750291167299755 0.204376331888688 no 706 0.226539680578165 1057 17682944
SGTC_2802 7925815 54.55 µM 0.74959685248844 0.204582747322296 no 707 0.226748773535555 1100 1262923
SGTC_632 0781-2353 4.65 µM 0.748063687839882 0.205038986698758 no 708 0.227210871684888 1144 6811515 YHR007C ERG11
SGTC_1002 4049-0206 172 µM 0.746033244152534 0.205644136365197 no 709 0.22782366658674 1164 4662749
SGTC_237 nikkomycin 200 µM 0.745091152080758 0.205925275415778 no 710 0.22810830879025 1129 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_495 decylubiquinone 155 µM 0.74441031118981 0.206128593754483 no 711 0.228314141401267 1093 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2220 6782180 200 µM 0.744066166961612 0.206231410221018 no 712 0.228418223190382 1062 833803
SGTC_337 1315-0038 354 µM 0.743994211307158 0.206252911521107 no 713 0.228439988578878 1080 1626437
SGTC_548 1436-0017 110 µM 0.743858386041967 0.20629350152572 no 714 0.228481076637812 1178 9677137
SGTC_616 4092-0450 108 µM 0.743575369629824 0.206378093322121 no 715 0.228566704348823 1151 787165
SGTC_2274 7947094 46.08 µM 0.742743061559619 0.206626983962776 no 716 0.228818626796538 1152 2971028
SGTC_2991 9074669 71.4286 µM 0.741936015065792 0.206868490135026 no 717 0.22906305185176 1125 17333109
SGTC_1276 0871-0068 94.2 µM 0.741704658282057 0.206937753739518 no 718 0.229133148417163 1096 3414906
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.741615011466068 0.206964595896251 no 719 0.229160312876984 1136 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2692 st077426 47.7 µM 0.740353888707585 0.207342421096726 no 720 0.229542645182663 1141 25238571
SGTC_658 3253-0951 102 µM 0.738986537785834 0.207752532081681 no 721 0.229957586012979 1153 1184878
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.738150677037261 0.20800346847197 no 722 0.230211445697227 1112 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3101 9120531 49.47 µM 0.73760445886084 0.208167546977937 no 723 0.230377422542934 1146 24824904
SGTC_2441 5730946 39.09 µM 0.737406143388616 0.208227137867186 no 724 0.230437700319517 1131 1774275
SGTC_1152 3909-8331 15.9 µM 0.736787266384143 0.208413166029897 no 725 0.230625864002069 1113 16001939
SGTC_2046 4110841 106 µM 0.736051801934978 0.208634366606326 no 726 0.230849586580379 1146 44119630 YMR134W ERG29
SGTC_2684 capsaicin 100 µM 0.735748457432715 0.208725641739841 no 727 0.230941896914303 1134 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_134 0269-0018 6.916 µM 0.735150737757059 0.20890556202937 no 728 0.231123848434473 1051 4378915
SGTC_2087 5276107 200 µM 0.7344252769389 0.209124056522152 no 729 0.231344792995071 1144 144405
SGTC_2600 tangeritin 87.95 µM 0.732772253648885 0.209622416858874 no 730 0.231848673439884 1127 68077 A bioactive flavone.
SGTC_751 0833-0568 350 µM 0.732360362750078 0.209746704058459 no 731 0.231974322561234 1153 6954252
SGTC_1702 st027038 51 µM 0.730852892148712 0.210201949404769 no 732 0.232434506244375 1162 5521182
SGTC_3182 9108849 49.47 µM 0.730837113208747 0.210206717598804 no 733 0.232439325745372 1169 17133045
SGTC_2675 theaflavin digallate 100 µM 0.730775965906762 0.2102251961322 no 734 0.232458003030892 1121 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2129 girgensonine 121.053 µM 0.730299272025804 0.210369284314669 no 735 0.232603636558589 1160 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2391 6285546 200 µM 0.729752023187735 0.210534770303647 no 736 0.232770887671149 1129 846083
SGTC_2233 sulbentine 40.3845 µM 0.728998165981735 0.21076285894851 no 737 0.233001392176796 1150 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1671 st016596 74.5 µM 0.728658853563748 0.21086556932075 no 738 0.233105184004472 1194 2829167
SGTC_3301 9125354 19.7965 µM 0.728164233708529 0.211015344051716 no 739 0.233256528591743 1105 41905162
SGTC_2334 9017922 200 µM 0.726472190720709 0.211528179141605 no 740 0.2337746748043 1153 3163164
SGTC_518 1021-0119 62.6 µM 0.725124340725835 0.211937215721028 no 741 0.234187876514116 1073 1097762
SGTC_519 k048-0011 62.8 µM 0.724975550393653 0.211982397963092 no 742 0.234233514979633 1120 6836379
SGTC_3225 9130819 49.47 µM 0.72428203809347 0.212193066876019 no 743 0.234446300984465 1143 4547121
SGTC_2528 xanthyletin 44.79 µM 0.724051106854753 0.212263244238867 no 744 0.234517179889052 1165 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_220 paclitaxel 373.376 µM 0.723080848283416 0.212558242918693 no 745 0.234815107395669 1094 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2000 st075254 36.4 µM 0.722665603266818 0.212684567690781 no 746 0.234942676391313 1107 17234175
SGTC_2937 9044753 11.33 µM 0.72180802305599 0.212945597249728 no 747 0.235206258034151 1188 6465530 YGL099W LSG1
SGTC_835 0312-0010 67.2 µM 0.720573786284685 0.213321601177055 no 748 0.235585893440407 1127 1626196
SGTC_3351 9150312 21.596 µM 0.718949443556784 0.21381703835742 no 749 0.236086035191515 1148 4904905
SGTC_2041 5107442 45.335 µM 0.716780958920226 0.214479486323267 no 750 0.236754631215162 1170 793005
SGTC_3286 9117135 37.221 µM 0.716588530621293 0.214538328619998 no 751 0.236814011755301 1141 3438150
SGTC_2825 7998094 58.44 µM 0.7151867806167 0.214967250277087 no 752 0.237246818191041 1122 2987815
SGTC_2734 clemastine 41.6 µM 0.713864674806071 0.215372257593872 no 753 0.237655431387599 1121 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2558 carylophyllene oxide 100 µM 0.713847101337415 0.215377643942521 no 754 0.237660865285133 1253 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1408 3909-7976 48.8 µM 0.71238798848184 0.215825141291375 no 755 0.238112275730305 1208 24152374
SGTC_2658 polymyxin b sulfate 77.05 µM 0.709434331059883 0.216732650194494 no 756 0.239027494778835 1160 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1716 st033144 30.6155 µM 0.707069167651534 0.217460933157822 no 757 0.239761747644838 1191 674617
SGTC_3307 9126885 69.2785 µM 0.706172309476709 0.217737463423009 no 758 0.240040494141572 1174 24824909
SGTC_3184 9108758 49.47 µM 0.704761467506412 0.218172881760455 no 759 0.240479345869735 1185 902885
SGTC_3153 9100258 49.47 µM 0.704560088733932 0.218235072787379 no 760 0.240542021683933 1138 25236848
SGTC_1052 3253-3998 198 µM 0.704071027514115 0.218386150190994 no 761 0.24069427092695 1179 5450317
SGTC_2983 9022671 12.99 µM 0.703577630407804 0.218538628033674 no 762 0.240847923104089 1178 6405161
SGTC_2320 7373003 200 µM 0.700764937317535 0.219409023506845 no 763 0.241724861496868 1203 5415828
SGTC_605 1315-0399 119 µM 0.700654695144752 0.219443178760212 no 764 0.241759267940437 1224 24020461
SGTC_1658 st012944 20 µM 0.700084036254996 0.219620029243147 no 765 0.241937412343729 1134 24207260
SGTC_362 0310-0100 9.03 µM 0.697651932351266 0.220374669417482 no 766 0.242697447793565 1206 790235
SGTC_2690 usnic acid 100 µM 0.697555912759071 0.220404493120001 no 767 0.242727480533153 1236 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2084 5306078 60.6385 µM 0.696615952026154 0.22069656723575 no 768 0.243021585034282 1143 679340
SGTC_1066 ketoconazole 628 nM 0.696489625232898 0.22073583766821 no 769 0.243061126137531 1219 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_224 benfluorex 43.875 µM 0.696336562125862 0.220783424815607 no 770 0.243109040541501 1197 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.694215199051644 0.221443558866075 no 771 0.243773631143817 1216 229346 A bile salt which induces apoptosis.
SGTC_3217 9129673 49.47 µM 0.693789163800428 0.221576270121169 no 772 0.243907219625327 1200 17248312
SGTC_161 4065-0411 162.148 µM 0.691839352656781 0.222184221890686 no 773 0.244519110149032 1196 1906281 YLR208W SEC13
SGTC_52 0329-0193 875 nM 0.690506269672858 0.22260042494611 no 774 0.244937934269853 1264 3739292
SGTC_866 0495-0101 262 µM 0.6900655851838 0.222738109143904 no 775 0.245076472082912 1177 635694
SGTC_1490 4089-0339 670 nM 0.68957350551871 0.222891908208846 no 776 0.245231216770693 1167 742542
SGTC_374 0880-0231 82.3 µM 0.689525125201338 0.222907032700163 no 777 0.245246433803848 1181 6833587
SGTC_756 0508-1999 28.3 µM 0.686639161640992 0.223810289880044 no 778 0.246155071898243 1192 6753853
SGTC_571 k831-0106 44.2 µM 0.68531594683242 0.224225128074555 no 779 0.24657228550681 1192 4783639
SGTC_1362 1611-0397 101 µM 0.685240237372235 0.224248876780353 no 780 0.246596168378993 1210 27816
SGTC_2450 5739737 12.93 µM 0.684526345330585 0.22447288217929 no 781 0.246821429584645 1212 2262825
SGTC_1755 st041960 45.185 µM 0.683611850347157 0.224760018293828 no 782 0.247110149817018 1218 2257073
SGTC_3047 9092122 49.47 µM 0.682835969996274 0.22500379496488 no 783 0.247355248843595 1182 17173831
SGTC_1661 st013063 9.66 µM 0.682388631491218 0.225144413951544 no 784 0.247496621205756 1241 721395
SGTC_2619 obliquin 87.91 µM 0.682175249642623 0.225211507176901 no 785 0.247564071464565 1205 6708593 A bioactive alkalod. YER133W GLC7
SGTC_900 1112-0045 141 µM 0.68102317185508 0.225573948255514 no 786 0.247928414219138 1149 56211 YIL048W NEO1
SGTC_1987 st072290 61.9 µM 0.679168682358855 0.226158059222546 no 787 0.248515494096424 1220 54697379
SGTC_1349 flufenamic acid 69 µM 0.67913241506773 0.226169490892963 no 788 0.24852698269364 1191 3371 A non-steroidal anti-inflammatory.
SGTC_2806 7952793 58.44 µM 0.678936338373236 0.226231301112269 no 789 0.248589099929759 1224 2972490
SGTC_799 1310-0557 151 µM 0.677677322535982 0.226628414168559 no 790 0.248988154017605 1244 5354492
SGTC_2807 7945238 51.95 µM 0.676925641952412 0.226865693293023 no 791 0.249226566974463 1247 17148797
SGTC_2092 5303694 80.6725 µM 0.676757315227327 0.226918847318244 no 792 0.249279972336601 1220 1963699
SGTC_144 4161-2749 112.381 µM 0.675764539189192 0.227232487870928 no 793 0.249595076140785 1158 797501 YMR168C CEP3
SGTC_1092 toremifene 6.32 µM 0.675341174099563 0.227366312812727 no 794 0.249729515136746 1236 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2836 9010338 19.48 µM 0.675220398646549 0.227404497854399 no 795 0.249767874262437 1143 2994051
SGTC_2362 9071156 126 µM 0.670970302080566 0.228750530372741 no 796 0.251119724342427 1240 653133
SGTC_405 ebelactone b 50 µM 0.670503081522497 0.228898774486433 no 797 0.25126857135842 1236 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_910 3454-3003 490 µM 0.670442006861897 0.228918156810427 no 798 0.251288031956508 1199 820824
SGTC_623 k072-0108 16.9 µM 0.670182811772248 0.229000423810083 no 799 0.251370629762824 1208 5382803
SGTC_3125 9127534 49.47 µM 0.668842169513028 0.229426200472113 no 800 0.251798081768203 1131 1639235
SGTC_1203 3992-3522 103 µM 0.668827578815065 0.229430836793942 no 801 0.251802735994194 1385 5322312
SGTC_1374 2889-5571 141 µM 0.66774823142461 0.229773954446627 no 802 0.25214715844109 1241 2853281
SGTC_3349 9149703 23.001 µM 0.667617872867104 0.229815414039391 no 803 0.252188772993589 1229 4910494
SGTC_1958 st076513 41.9 µM 0.665591281093029 0.230460495296143 no 804 0.252836190429096 1205 732122 YGL099W LSG1
SGTC_391 gliotoxin 8.33 µM 0.665575921836112 0.230465388138689 no 805 0.252841100454179 1283 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1292 0kpi-0043 232 µM 0.665047955129176 0.230633612431946 no 806 0.253009910602248 1234 3333905
SGTC_125 0133-0007 11.75 µM 0.664511924577455 0.230804476247903 no 807 0.253181359703152 1315 26541
SGTC_3171 9103192 49.47 µM 0.66444760324084 0.230824983912807 no 808 0.253201936955151 1278 13018434
SGTC_2814 7977482 42.97 µM 0.663698755559578 0.231063814979007 no 809 0.25344156800782 1288 6456762
SGTC_2160 5660466 132.927 µM 0.663326384265164 0.23118262721452 no 810 0.253560771071714 1192 2859134
SGTC_3013 9080133 71.4286 µM 0.662879494272364 0.231325261067623 no 811 0.253703867849817 1316 17050193
SGTC_1400 3771-8998 51.5 µM 0.662127362711314 0.231565429638111 no 812 0.253944800470951 1199 670767
SGTC_2851 9015922 71.43 µM 0.659133494368692 0.232522799832134 no 813 0.254905024446426 1255 2996893
SGTC_2525 harmine 47.85 µM 0.65823155954806 0.23281164863434 no 814 0.255194674177317 1221 5280953 A monoamine oxidase inhibitor
SGTC_853 0419-0306 21 µM 0.657867596445092 0.23292826593858 no 815 0.255311606968702 1208 762713
SGTC_2148 5546263 113.568 µM 0.656248518382758 0.233447427254684 no 816 0.255832117920224 1253 792097
SGTC_3024 9090631 49.47 µM 0.656074164560642 0.233503372489336 no 817 0.25588820325174 1207 25236383
SGTC_575 k072-0246 11.9 µM 0.656044700501465 0.233512827411161 no 818 0.255897681747844 1272 6796779
SGTC_1433 4060-0023 7.6 µM 0.653585860177883 0.234302609181697 no 819 0.256689328206695 1279 3840627
SGTC_2866 9034245 58.44 µM 0.653234847966307 0.234415475098956 no 820 0.256802443764557 1248 6462273
SGTC_2235 salicylic acid 500 µM 0.650759802326015 0.235212164840911 no 821 0.257600776266215 1260 338 A COX inhibitor and kinase inhibitor.
SGTC_1211 1056-0033 32.3 µM 0.64873713703145 0.23586434699451 no 822 0.258254147978294 1272 6741922
SGTC_767 0929-0023 86 µM 0.648580245170391 0.235914976363815 no 823 0.258304863864676 1318 1204563
SGTC_2329 6138490 200 µM 0.647323877663202 0.236320625055563 no 824 0.258711175482662 1294 720019
SGTC_1836 st055642 81 µM 0.647023059602537 0.236417808408914 no 825 0.258808509675855 1242 8571
SGTC_3110 9122132 49.47 µM 0.646664304580915 0.236533737839959 no 826 0.25892461501251 1342 918317
SGTC_1411 3909-8223 150 µM 0.646053221662776 0.236731277448173 no 827 0.259122444263771 1274 X1411
SGTC_1845 st056753 3.01 µM 0.64584388801118 0.236798967827252 no 828 0.259190230969576 1227 5375839
SGTC_2070 5230947 200 µM 0.645573475562886 0.236886424471541 no 829 0.259277809860161 1334 2835538
SGTC_1364 1653-0028 37.6 µM 0.644627480654658 0.237192517302146 no 830 0.259584310952172 1259 5718652
SGTC_2130 NSC 7 2.4545 µM 0.644016570794346 0.237390303038903 no 831 0.259782344300308 1277 21448
SGTC_3113 9123498 49.47 µM 0.643344084382407 0.237608129217437 no 832 0.260000428490041 1313 8897275
SGTC_1729 st035615 45.989 µM 0.642146268301381 0.237996387307296 no 833 0.260389108339658 1268 17385451
SGTC_485 niflumic acid 177 µM 0.642142722355413 0.237997537200321 no 834 0.260390259409331 1297 4488 A COX2 inhibitor.
SGTC_2969 9091408 28.7 µM 0.641304337267238 0.23826949741581 no 835 0.260662485907209 1241 4286311
SGTC_1106 tegaserod maleate 11.7 µM 0.640293000318839 0.238597787165868 no 836 0.260991065276673 1305 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_204 PMA1.184 62.41 µM 0.639598313754145 0.238823432489186 no 837 0.261216889515123 1297 2252213 YGL008C PMA1
SGTC_1158 4092-0494 91.8 µM 0.639365411781398 0.238899108898676 no 838 0.261292622256837 1365 1148199
SGTC_2137 5261020 140 µM 0.638911746673056 0.239046555110921 no 839 0.261440172932268 1263 763655
SGTC_3194 9111903 49.47 µM 0.637638236030001 0.239460725956955 no 840 0.261854599829864 1313 17087251
SGTC_797 k781-0471 270 µM 0.636443022780903 0.239849789120168 no 841 0.262243853387054 1289 23738129
SGTC_1786 berberine 21.6 µM 0.636137891762073 0.239949169916195 no 842 0.262343275041925 1252 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1305 1181-0477 144 µM 0.635804704955874 0.2400577140912 no 843 0.262451860232354 1323 6252086
SGTC_2351 9026858 72.31 µM 0.635638808208134 0.240111769206433 no 844 0.26250593436779 1230 1409300
SGTC_159 3970-0959 50 µM 0.635407383707961 0.240187186698102 no 845 0.262581376835591 1364 6615653
SGTC_2841 9004761 38.96 µM 0.63398473153419 0.240651089467582 no 846 0.263045393288394 1194 2991039
SGTC_2421 5690543 90.72 µM 0.633312967884265 0.240870309614995 no 847 0.263264643279439 1326 3397993
SGTC_1711 st032263 62.8 µM 0.631398448221337 0.241495680417784 no 848 0.263890015200083 1307 3958979
SGTC_1611 st001856 99.4 µM 0.630897029373409 0.24165961263701 no 849 0.264053927167887 1251 647478
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.630537197646879 0.241777292052556 no 850 0.26417158679271 1322 1273210
SGTC_505 gw-5074 63.9 µM 0.630451103412407 0.241805452932356 no 851 0.264199742285905 1346 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2214 7179297 48.276 µM 0.630018793804334 0.241946885576566 no 852 0.264341144078913 1332 769744
SGTC_1079 idarubicin 2.36 µM 0.628539171374127 0.242431292243696 no 853 0.264825397134508 1280 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2352 9027995 87.8 µM 0.627822655657419 0.242666057656988 no 854 0.26506006144014 1290 2997347
SGTC_3058 9093861 49.47 µM 0.627515923384836 0.242766595685298 no 855 0.265160550853952 1319 17217477
SGTC_305 1682-2595 20.8 µM 0.627294097710317 0.242839317815121 no 856 0.265233235834292 1309 226033
SGTC_3150 9097574 49.47 µM 0.626756126959257 0.243015732189418 no 857 0.265409553168423 1291 17217476
SGTC_664 1222-0054 14.9 µM 0.626579471910261 0.243073677015213 no 858 0.265467463983492 1291 6813991
SGTC_1514 1189-1591 158 µM 0.626503221764503 0.243098690221657 no 859 0.265492462182037 1378 767698 YMR146C TIF34
SGTC_2385 9074692 200 µM 0.62597054658218 0.24327346856755 no 860 0.265667130171071 1271 17046906
SGTC_3319 9138450 16.7555 µM 0.62575613059898 0.243343840686002 no 861 0.265737455144831 1286 2029690
SGTC_861 0443-0273 110 µM 0.625459225500547 0.243441304197772 no 862 0.265834850793519 1318 6149169
SGTC_3031 9088762 49.47 µM 0.624176487074065 0.243862624432269 no 863 0.266255843376367 1261 205253
SGTC_2158 5657123 3.6195 µM 0.62092845985308 0.244931208492466 no 864 0.26732334737253 1285 2858827
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.620615108649129 0.245034432505804 no 865 0.267426448185791 1339 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_708 3448-5400 146 µM 0.618815512617197 0.245627707488753 no 866 0.268018950834003 1297 3462195
SGTC_1413 3910-0535 34.4 µM 0.617498155242036 0.246062490861135 no 867 0.268453098841412 1352 2876951
SGTC_2581 avocatin a 64 µM 0.617386070671301 0.246099502534139 no 868 0.268490053723563 1318 6710728 A skin care supplement.
SGTC_770 0389-1121 67.2 µM 0.615927047825432 0.246581561731393 no 869 0.26897133456169 1411 6753108
SGTC_2739 tacrine 100.86 µM 0.614357465883449 0.247100713732821 no 870 0.269489568101026 1328 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2406 ethylparaben 405.7 µM 0.612039127014568 0.247868591475916 no 871 0.270255935321595 1208 8434 A possible steroid mimic.
SGTC_3075 9116269 49.47 µM 0.610920548848331 0.248239540778078 no 872 0.27062609012341 1349 17015205 YNL244C SUI1
SGTC_2553 4-methylesculetin 85.09 µM 0.61064925437226 0.248329553590677 no 873 0.270715903796504 1321 5319502
SGTC_512 prima-1 270 µM 0.609975506973476 0.248553171527737 no 874 0.270939016293555 1370 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_527 4476-4215 268 µM 0.608560913090324 0.249023026573496 no 875 0.271407759600657 1346 4418754
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.608413817769258 0.249071911155304 no 876 0.27145652464972 1366 676296 Flavone; oxidizing agent.
SGTC_1725 st036284 20.55 µM 0.608198697182584 0.249143411947361 no 877 0.271527849297104 1371 707914
SGTC_2493 resveratrol 26.09 µM 0.605119428517514 0.250168080609783 no 878 0.272549822969142 1276 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2339 9000433 200 µM 0.603766498625247 0.25061899224185 no 879 0.27299944782463 1289 2988954
SGTC_1009 4106-0057 9.87 µM 0.603671254158102 0.250650752034667 no 880 0.273031114666964 1337 2928005
SGTC_3261 9137475 49.47 µM 0.602807532760144 0.250938861993338 no 881 0.273318367513085 1259 17027690
SGTC_716 1683-5115 658 µM 0.602784103236346 0.250946679777439 no 882 0.273326161690702 1349 723597
SGTC_531 3788-1495 174 µM 0.602564981930342 0.25101980073643 no 883 0.2733990609624 1322 2896655
SGTC_2402 5553605 200 µM 0.602315337126929 0.2511031211479 no 884 0.273482126799669 1400 6758546
SGTC_2262 9014885 67.46 µM 0.601896277450271 0.25124301764777 no 885 0.273621591161339 1294 6457424
SGTC_10 0279-0212 42.575 µM 0.601721572702604 0.251301352257674 no 886 0.273679743835646 1339 39851 YBR002C RER2
SGTC_1054 3429-0080 167 µM 0.601719143353421 0.251302163477504 no 887 0.2736805525182 1370 1162877
SGTC_2787 5284540 71.43 µM 0.599852640198201 0.251925844038024 no 888 0.274302223832179 1363 736958
SGTC_1778 st046819 58.9 µM 0.598065274551052 0.252523846106391 no 889 0.274898189805944 1360 671715
SGTC_1205 4161-2785 76 µM 0.597612037387892 0.252675605247578 no 890 0.275049415209033 1305 3498106
SGTC_3025 9087895 49.47 µM 0.59613638342835 0.253170036715372 no 891 0.275542060059396 1347 17173641
SGTC_145 3737-0113 38.366 µM 0.593156961309684 0.254169868273942 no 892 0.276538056352719 1349 6849351
SGTC_2886 9058944 51.95 µM 0.592758458165434 0.254303754403149 no 893 0.276671406376392 1246 4949929
SGTC_2598 perillyl alcohol 100 µM 0.592556772100327 0.254371529479041 no 894 0.27673890804358 1405 10819 An apoptosis inducer.
SGTC_1445 4239-0156 97.7 µM 0.592111644705531 0.254521144670039 no 895 0.276887914863452 1470 4008346
SGTC_3336 9143619 71.43 µM 0.591637343215184 0.254680616511849 no 896 0.277046730963202 1378 45595730
SGTC_19 0279-0214 38.434 µM 0.590832290458754 0.25495141480642 no 897 0.277316398527247 1391 3566274 YBR002C RER2
SGTC_903 1134-0042 114 µM 0.588895068973163 0.255603661463275 no 898 0.277965832898537 1334 701009
SGTC_311 1315-0136 58 µM 0.586900145394669 0.256276245669592 no 899 0.278635386070303 1417 6759207
SGTC_1776 st049249 45.9 µM 0.586709855924568 0.256340449520176 no 900 0.278699293642239 1329 1822314
SGTC_1275 0867-0008 21.1 µM 0.58611729271541 0.25654043460383 no 901 0.278898348124322 1365 3422836
SGTC_942 3253-1115 227 µM 0.584431448549118 0.257109836973996 no 902 0.279465036783372 1428 46497897
SGTC_2740 felodipine 17.08 µM 0.583985645927534 0.257260518860555 no 903 0.279614984690741 1391 3333 L-type calcium channel blocker
SGTC_207 4185-0010 4.486 µM 0.58347570142008 0.257432937059747 no 904 0.279786554909364 1406 3761753
SGTC_2415 st077333 57.7 µM 0.582370570216345 0.257806800774642 no 905 0.280158550159365 1524 2766255
SGTC_2948 9070189 9.45 µM 0.57953548181065 0.258767192714322 no 906 0.281113956210976 1330 6473636 YDL196W YDL196W
SGTC_1026 k007-1105 30.6 µM 0.577234219710688 0.259548109164577 no 907 0.281890621739668 1369 7066794
SGTC_473 2-arachidonoylglycerol 10 µM 0.576949124307737 0.259644938851158 no 908 0.281986912073389 1328 5282280 An endocannabinoid.
SGTC_2395 5646831 180.19 µM 0.576689495635498 0.25973313524869 no 909 0.282074614856492 1425 6808628
SGTC_550 4123-0385 25.7 µM 0.575566310343153 0.260114861664738 no 910 0.282454179032827 1355 5731123
SGTC_3341 9147222 25.867 µM 0.575140200879718 0.26025975511356 no 911 0.2825982407857 1367 1939759
SGTC_1600 coumarin 106 71.1 µM 0.57339203719789 0.26085463237477 no 912 0.283189640299343 1414 100336 A hepatotoxic, DNA x-linker.
SGTC_3237 9133362 49.47 µM 0.56955482893782 0.262162832376727 no 913 0.284489836527596 1418 43845137
SGTC_3089 9117425 49.47 µM 0.568589929558918 0.262492318802312 no 914 0.284817230279079 1305 9401657
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.568500891594108 0.262522733481857 no 915 0.284847450231255 1354 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_746 1095-0025 46.6 µM 0.567273741767955 0.262942102038847 no 916 0.285264107075285 1407 6749286
SGTC_1682 st012968 530 nM 0.566839065828615 0.263090731134674 no 917 0.285411763152263 1339 24207270
SGTC_964 1287-0107 19.4 µM 0.566542703460663 0.263192091166686 no 918 0.285512456033715 1468 51516812 YPR165W RHO1
SGTC_60 0986-0278 202 µM 0.566109621251815 0.263340247144322 no 919 0.285659631624512 1206 3110598
SGTC_2467 5474540 200 µM 0.565041895284176 0.263705694463291 no 920 0.286022634177515 1344 5413519
SGTC_1791 st048313 56.1 µM 0.564026816106936 0.264053362225444 no 921 0.286367941155869 1379 1204976
SGTC_735 3076-0345 636 µM 0.56334814171671 0.264285940512518 no 922 0.286598921158064 1475 2888990
SGTC_1652 st011932 78 µM 0.562673288432873 0.264517312709874 no 923 0.286828688268166 1419 1551076
SGTC_1420 4'-methoxyflavone 42 µM 0.561321140795695 0.264981203949665 no 924 0.287289316108781 1402 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2327 6189656 200 µM 0.560072802518152 0.265409847233254 no 925 0.287714890362956 1483 5349088
SGTC_702 1488-0190 94 µM 0.559454739138516 0.265622202492338 no 926 0.287925706154128 1425 949357
SGTC_41 0478-0632 82.643 µM 0.55796316411618 0.266135035000447 no 927 0.288434768990382 1408 3750424
SGTC_1849 st056239 19.2 µM 0.557528582171563 0.266284546986949 no 928 0.288583168162797 1307 5393181
SGTC_606 k015-0008 38.6 µM 0.556614909083322 0.26659902232424 no 929 0.288895282571103 1508 1970475
SGTC_2365 9042475 200 µM 0.555838634785702 0.266866354117097 no 930 0.289160585757758 1393 6464479
SGTC_281 1672-3440 14.9 µM 0.555703899080141 0.266912767920303 no 931 0.289206645336048 1415 6833000
SGTC_3134 9127454 49.47 µM 0.555434891796502 0.267005447840789 no 932 0.289298616146048 1467 24262820
SGTC_2586 curcumin 80 µM 0.551492256116633 0.2683656490655 no 933 0.290648136866605 1479 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2915 7971052 15.16 µM 0.550610885881461 0.268670195900132 no 934 0.290950222432856 1289 5741558
SGTC_2942 9052777 62.25 µM 0.549699199025037 0.268985400888791 no 935 0.291262853166453 1472 6469503
SGTC_912 3474-0017 2.18 µM 0.549470119897907 0.269064631469647 no 936 0.291341432386894 1496 3360550
SGTC_934 2950-0684 338 µM 0.548141872639185 0.269524257160581 no 937 0.291797245509267 1507 1121253
SGTC_2356 9061756 188.97 µM 0.546650506937967 0.270040796734507 no 938 0.292309431419333 1426 20104043
SGTC_2181 6316240 54.2555 µM 0.546113176665217 0.270227024202926 no 939 0.292494071392563 1378 12779990
SGTC_1668 st014914 51.6 µM 0.545833481847691 0.27032398600321 no 940 0.292590202897553 1415 2839556
SGTC_2738 aclarubicin 5.55 µM 0.545713023847633 0.270365750534862 no 941 0.292631609004864 1402 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2381 9035592 200 µM 0.543912808592962 0.270990295230513 no 942 0.293250737191359 1360 4749657
SGTC_1016 4226-1401 38 µM 0.543509967185535 0.271130150594015 no 943 0.293389365093397 1414 2901613
SGTC_3117 9124945 49.47 µM 0.543495269028388 0.271135254067007 no 944 0.293394423674556 1316 17592065
SGTC_2853 9015042 58.44 µM 0.543145542613792 0.271256699697855 no 945 0.293514798943912 1329 6457456
SGTC_2944 9067346 25.62 µM 0.5393241446718 0.27258547863196 no 946 0.294831605813308 1437 6473075
SGTC_2156 5649887 115 µM 0.537575179085698 0.273194706074098 no 947 0.295435184946437 1507 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_511 blebbistatin 171 µM 0.537154953908482 0.27334118603188 no 948 0.295580291969181 1490 3476986 A myosin inhibitor.
SGTC_339 3091-4833 71.4 µM 0.535308649764156 0.273985221843026 no 949 0.296218223049554 1436 3240077
SGTC_649 1123-0311 367 µM 0.534651304977897 0.274214700605308 no 950 0.296445499776282 1418 693629 YIL048W NEO1
SGTC_212 3807-4682 38.772 µM 0.532723893227598 0.274888105879107 no 951 0.297112361990523 1543 3125501 YBL034C STU1
SGTC_2151 5563267 85.4165 µM 0.532305925337178 0.275034244293729 no 952 0.297257064504857 1433 5310824
SGTC_459 nigericin 15.3 µM 0.531188632409411 0.275425082705526 no 953 0.297644034769672 1465 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1886 st057356 49.9 µM 0.529868488230567 0.275887232071058 no 954 0.298101557869091 1373 24207747
SGTC_1558 st069300 45.6 µM 0.529331419010171 0.276075355491495 no 955 0.298287781895302 1478 24208000
SGTC_1269 0831-0796 3.05 µM 0.528867541374162 0.276237892200565 no 956 0.298448670001744 1500 927758
SGTC_449 xestospongin c 11.1929 µM 0.528603466509029 0.276330441579518 no 957 0.298540277533355 1477 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_992 3909-8734 162 µM 0.52581068023535 0.277310149495088 no 958 0.299509876572094 1431 4288319
SGTC_796 1234-0020 70.7 µM 0.525208420259696 0.27752164440756 no 959 0.299719156038267 1407 46495034
SGTC_2960 9079389 5.97 µM 0.525027720771915 0.277585115799902 no 960 0.299781960262419 1536 16457355
SGTC_2258 7960471 200 µM 0.524623435950542 0.277727148084653 no 961 0.299922495765943 1402 2974708
SGTC_1040 k898-0338 155 µM 0.522837178811422 0.278355115769025 no 962 0.300543782297395 1580 20969351
SGTC_865 0488-0499 301 µM 0.522642988734883 0.278423425951982 no 963 0.300611359475458 1451 9634651
SGTC_1048 3161-0300 24.5 µM 0.521494422509398 0.278827623695449 no 964 0.301011194987714 1421 2165101
SGTC_163 TUB2.036 7.546 µM 0.521384131030929 0.278866451948902 no 965 0.301049601946911 1464 15992207 YJR013W GPI14
SGTC_551 k048-0028 34.9 µM 0.521035037049599 0.278989368263574 no 966 0.301171182000279 1509 6836383
SGTC_2742 clothiapine 36.27 µM 0.520887298346703 0.279041395132758 no 967 0.301222642081718 1501 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_810 3825-7150 143 µM 0.520456651445134 0.279193076352015 no 968 0.301372666835978 1570 22330411 YGL099W LSG1
SGTC_906 1165-0455 526 µM 0.520374590603126 0.279221984132319 no 969 0.301401258242606 1410 3252859
SGTC_654 1124-0271 80.9 µM 0.519744509418948 0.279443992878464 no 970 0.301620830015317 1419 5403748
SGTC_507 nimesulide 162 µM 0.519711632073439 0.279455579545431 no 971 0.301632289143885 1520 4495 A COX2 inhibitor.
SGTC_2497 7-hydroxyflavone 100 µM 0.518485046023192 0.279888020876055 no 972 0.302059945470842 1491 5281894
SGTC_3121 9125696 49.47 µM 0.518211226416792 0.279984602150021 no 973 0.302155451424557 1505 1235365
SGTC_871 0574-0004 149 µM 0.517599763520864 0.280200334809751 no 974 0.302368773407365 1457 9551173
SGTC_3274 9138298 49.47 µM 0.517541975366843 0.280220727443 no 975 0.302388937541153 1420 17015756
SGTC_2426 5582046 32.21 µM 0.515329375480452 0.281002063373588 no 976 0.303161437484971 1499 2251934
SGTC_2117 5521686 200 µM 0.513649927108842 0.281595829313186 no 977 0.303748383147813 1429 803312
SGTC_1253 0550-0034 176 µM 0.513279044525932 0.281727035701669 no 978 0.303878070179312 1453 5969915
SGTC_976 1348-1067 47.6 µM 0.511573698766577 0.282330711455477 no 979 0.3044746983829 1471 5310671 YGL099W LSG1
SGTC_2796 7949634 45.45 µM 0.510513646998535 0.28270627282533 no 980 0.304845828098077 1429 2971588
SGTC_3061 glucosamine 200 µM 0.510019214386883 0.282881525374454 no 981 0.305019000286821 1474 91431 and experimental redox chemotherapeutic
SGTC_1236 0330-0013 258 µM 0.509867628274812 0.282935265798768 no 982 0.305072101202875 1451 4617066
SGTC_640 3381-0960 37.1 µM 0.507066585455774 0.283929174774969 no 983 0.306054049726669 1551 1745025
SGTC_588 3970-1144 52.9 µM 0.504460312541428 0.284855470547841 no 984 0.30696897226175 1484 1888707
SGTC_1553 gossypol 38.6 µM 0.503674386761297 0.285135079190722 no 985 0.307245105048591 1439 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1780 st038448 24.544 µM 0.503493924607189 0.285199300634861 no 986 0.307308525351676 1569 728868 YDL195W SEC31
SGTC_2928 9011484 9.79 µM 0.503149437597677 0.285321913081834 no 987 0.307429605352054 1481 2994751
SGTC_3162 9099653 49.47 µM 0.502947042905977 0.285393962654183 no 988 0.307500752654471 1473 25237511
SGTC_1137 ixabepilone 100 µM 0.5017094726788 0.285834708053179 no 989 0.307935950098253 1450 154225 A novel microtubule stabilizer.
SGTC_2774 tamoxifen 10.92 µM 0.499748124835364 0.28653388017055 no 990 0.308626220821278 1494 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1545 lovastatin 49.4 µM 0.498731111489441 0.286896739479927 no 991 0.308984411997287 1526 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1039 k821-0043 94 µM 0.498715244121419 0.286902402508986 no 992 0.308990001910365 1577 15992768
SGTC_1261 0712-0010 12.7 µM 0.497561923158122 0.287314162009449 no 993 0.309396423595824 1571 2840123
SGTC_1850 st056238 17 µM 0.497405924521996 0.287369878218455 no 994 0.309451414269604 1468 5393177
SGTC_104 0074-0074 590.992 µM 0.497310386539475 0.287404002926169 no 995 0.309485094222481 1420 3943124
SGTC_1258 0671-0043 57.1 µM 0.4965139663767 0.287688546602028 no 996 0.309765918037703 1453 4298767
SGTC_2207 7258803 200 µM 0.495918941240234 0.287901223043397 no 997 0.309975800930532 1512 3666799
SGTC_211 3455-0679 143.504 µM 0.495590957196402 0.288018484241371 no 998 0.310091517049212 1498 748649
SGTC_648 0375-0473 33.3 µM 0.495567321495124 0.288026935372741 no 999 0.310099856692632 1512 1713139
SGTC_392 N-ethylmaleimide 8.33 µM 0.495351852118712 0.288103983544003 no 1000 0.310175887617135 1461 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_332 4112-0506 40.9 µM 0.4932492352501 0.288856353485499 no 1001 0.310918246495423 1514 2790355
SGTC_2473 5854593 8.94 µM 0.492857460811151 0.288996642514013 no 1002 0.311056653260595 1469 2872951
SGTC_890 0929-0006 47.2 µM 0.491745468620557 0.28939500610133 no 1003 0.311449645362062 1446 1378169
SGTC_2257 7960413 200 µM 0.491287214482929 0.289559247537291 no 1004 0.311611660733966 1571 2974689 YIL048W NEO1
SGTC_3128 9127691 49.47 µM 0.491123687559984 0.289617867305522 no 1005 0.31166948437529 1506 41316314
SGTC_287 k060-0039 29.6 µM 0.491028721206863 0.289651912609072 no 1006 0.311703066912247 1566 5861974
SGTC_1191 1487-1166 10.6 µM 0.490663983571467 0.289782687996122 no 1007 0.311832062045863 1589 3955771
SGTC_2939 9044578 71.43 µM 0.490262170385791 0.28992678875136 no 1008 0.311974196250608 1447 2653634
SGTC_2741 miltefosine 3.04 µM 0.488892171746248 0.290418358654786 no 1009 0.312459019082875 1480 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1531 st059297 52.4 µM 0.488618320482957 0.290516666137543 no 1010 0.312555970087449 1512 7566702
SGTC_2767 sibutramine 71.45 µM 0.486962220078148 0.291111506818214 no 1011 0.313142552204227 1610 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2488 5268135 45.7 µM 0.486415978206208 0.291307831485882 no 1012 0.313336132072695 1574 1270356 YLR208W SEC13
SGTC_1738 st035555 74 µM 0.485611561763242 0.291597059067467 no 1013 0.313621298753108 1508 5331140
SGTC_1509 1326-1131 80 µM 0.484882562438883 0.291859286046237 no 1014 0.313879826208682 1500 768313
SGTC_475 α-linolenic acid 10 µM 0.484463199293355 0.292010184129585 no 1015 0.314028587775392 1569 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1329 1447-1697 50.6 µM 0.483515596824658 0.292351290558562 no 1016 0.314364844068707 1484 2840515
SGTC_1521 st012942 49.4 µM 0.482819469389572 0.292601992054165 no 1017 0.314611962761481 1685 24207259
SGTC_1271 0832-2808 169 µM 0.482403470417912 0.292751856488946 no 1018 0.314759678144436 1606 3663794
SGTC_284 0988-0104 32.6 µM 0.481763113608409 0.292982615905166 no 1019 0.314987117774156 1549 4666532
SGTC_2995 9067767 71.4286 µM 0.481724457871275 0.29299654861366 no 1020 0.315000849626617 1522 11673567
SGTC_2474 5321570 43.32 µM 0.479099156685397 0.293943505888689 no 1021 0.315934044829409 1578 2841384
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.474740007639157 0.295518987517449 no 1022 0.317486149057268 1549 368090
SGTC_452 diindolylmethane 8 µM 0.473618195549216 0.295925059682053 no 1023 0.317886098885668 1540 3071 Inhibits expression of several cancer promoting factors.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.473454903052512 0.295984189455361 no 1024 0.317944333858682 1532 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2437 5741531 144.16 µM 0.472434852665662 0.296353682155429 no 1025 0.318308216102144 1637 2262990
SGTC_1138 3761-0006 1.03 µM 0.472419508744501 0.296359241795855 no 1026 0.318313691073951 1538 12061087
SGTC_1867 st057372 64 µM 0.472295621810265 0.29640413212581 no 1027 0.318357897490994 1504 688837
SGTC_3284 9108171 64.8615 µM 0.469890387663481 0.297276283751881 no 1028 0.31921666609368 1531 8687505
SGTC_2172 5754775 163.918 µM 0.469523032039708 0.297409592162202 no 1029 0.319347912910287 1466 2263357
SGTC_1232 0279-0259 161 µM 0.468928694661857 0.297625326997238 no 1030 0.319560302469986 1513 1560000
SGTC_523 1934-0222 13.7 µM 0.465851316861419 0.298743505756147 no 1031 0.320660965024245 1500 1361595
SGTC_644 1498-1197 63.3 µM 0.465408941648491 0.298904401590745 no 1032 0.320819316037496 1569 6741615
SGTC_619 1652-1634 108 µM 0.464466437465903 0.299247330029728 no 1033 0.321156800093345 1528 5400454
SGTC_2572 astragaloside iv 100 µM 0.462863556706717 0.299830944838093 no 1034 0.321731085520056 1548 45006101 An anti-inflammatory agent.
SGTC_3004 9076122 71.4286 µM 0.462783351350399 0.299860161438329 no 1035 0.321759832967865 1606 44782551
SGTC_150 3970-0969 77.2 µM 0.461899081971501 0.300182361792542 no 1036 0.322076846190359 1573 6615640
SGTC_139 0099-0334 718.624 µM 0.461439065427063 0.300350039440719 no 1037 0.322241814723596 1555 97690
SGTC_396 dithiazanine 1.25 µM 0.459838140077436 0.300933912033911 no 1038 0.322816202367424 1484 10578 An antihelmenthic.
SGTC_2669 eugenol 100 µM 0.459506188781203 0.301055041841857 no 1039 0.3229353544252 1585 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_398 bronopol 33.3 µM 0.458415870096017 0.30145305623071 no 1040 0.323326846048448 1581 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_262 fenpropimorph 62.5 µM 0.456840810852746 0.302028440048248 no 1041 0.32389273491009 1503 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3234 9132280 49.47 µM 0.456359517754157 0.302204359235236 no 1042 0.324065735679378 1536 17612295
SGTC_1964 st076914 61 µM 0.454640879031996 0.302832920067011 no 1043 0.324683810160456 1548 24208661
SGTC_2366 9070441 60.58 µM 0.453442788236761 0.30327144594151 no 1044 0.325114965736722 1493 6837235
SGTC_3020 9089140 49.47 µM 0.452384738243129 0.303658949870706 no 1045 0.325495919821516 1549 17217859
SGTC_2591 skatole 100 µM 0.451560970906532 0.303960802237237 no 1046 0.325792646026596 1559 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2416 tofa 880 nM 0.45140760599454 0.304017014381413 no 1047 0.325847901232587 1455 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2673 kobusone 100 µM 0.451388489330545 0.304024021450192 no 1048 0.325854788964071 1606 6710676 An epoxy ketone and protein crosslinker.
SGTC_1267 0828-0272 9.49 µM 0.451217634457218 0.304086650210137 no 1049 0.325916350591257 1664 745334
SGTC_1798 st045719 60.953 µM 0.450928082176227 0.30419280195594 no 1050 0.326020691548687 1524 3980186
SGTC_467 ro 31-8220 72.8 µM 0.45028351985031 0.304429161942356 no 1051 0.326253010259177 1605 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_936 3005-4620 401 µM 0.449718689042904 0.304636351681989 no 1052 0.326456646891109 1662 777207
SGTC_715 0868-0130 184 µM 0.449635724336136 0.304666789857481 no 1053 0.326486562248366 1710 2876258
SGTC_655 k060-0012 42 µM 0.448653857525548 0.305027120808871 no 1054 0.326840687823238 1525 5994525
SGTC_1997 st073024 93.8 µM 0.448512318534092 0.305079079180129 no 1055 0.326891748941362 1565 686268
SGTC_1502 4534-4282 27.7 µM 0.448411746020742 0.30511600131681 no 1056 0.326928033104267 1563 3278949
SGTC_957 1187-1561 14.1 µM 0.447175125931245 0.30557015078889 no 1057 0.327374309792981 1536 1538454
SGTC_589 1227-0070 34.1 µM 0.446556236852121 0.305797550601304 no 1058 0.327597749821302 1568 2841384
SGTC_710 3448-4187 58 µM 0.444024049352103 0.306728737394758 no 1059 0.328512598277113 1572 3946412
SGTC_2004 4023728 41.89 µM 0.441734607700443 0.307571732108018 no 1060 0.32934063167402 1656 360084 YDR527W RBA50
SGTC_136 0097-0015 404.482 µM 0.440831904235748 0.30790439617948 no 1061 0.32966734728258 1593 4861337
SGTC_961 1252-1571 372 µM 0.439761835526225 0.30829894222433 no 1062 0.33005480584269 1681 6813498
SGTC_2890 9046729 58.44 µM 0.438584424490264 0.308733322576196 no 1063 0.330481342439621 1494 903329
SGTC_817 1391-0715 46 µM 0.438520086513569 0.308757066402067 no 1064 0.330504656287194 1547 1353946
SGTC_3092 9117248 49.47 µM 0.437485450259277 0.309139006974809 no 1065 0.330879662808884 1656 17141857
SGTC_2862 9027634 71.43 µM 0.435769894201786 0.30977276681855 no 1066 0.331501844429257 1490 5012562
SGTC_1986 st071812 45 µM 0.43548607752303 0.309877668831087 no 1067 0.331604821270994 1575 11838594
SGTC_1068 loratadine 26.9 µM 0.434634253744144 0.310192605946529 no 1068 0.33191396380374 1555 3957 A H1 histamine antagonist.
SGTC_2020 4017018 200 µM 0.433964973037296 0.310440150773317 no 1069 0.332156938410362 1562 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3088 9117578 49.47 µM 0.433850506335571 0.310482496828663 no 1070 0.33219850129069 1593 678341
SGTC_2111 5486399 200 µM 0.433490969305688 0.310615521056094 no 1071 0.332329062673653 1555 689674
SGTC_3262 9137218 49.47 µM 0.433375887665488 0.310658105064121 no 1072 0.332370857434336 1523 17650664
SGTC_2981 9013952 38.96 µM 0.43318410016273 0.310729078411603 no 1073 0.332440514468743 1476 2996344
SGTC_775 4577-0580 57.3 µM 0.431364714331767 0.311402714787502 no 1074 0.333101601198173 1634 2006902
SGTC_2072 5231554 129 µM 0.430894960363774 0.311576746194912 no 1075 0.333272374008109 1699 789545
SGTC_3007 9078383 71.4286 µM 0.430851935600046 0.311592687835851 no 1076 0.333288016817588 1581 6496995
SGTC_625 k213-0058 121 µM 0.430220997509062 0.311826505114021 no 1077 0.333517444615499 1656 3655420
SGTC_31 0508-1974 57.237 µM 0.427437124418634 0.31285907635054 no 1078 0.334530486101061 1628 6810525
SGTC_38 0929-0051 58.268 µM 0.42597225190362 0.313403005607509 no 1079 0.335064032717483 1737 1379719
SGTC_3001 9076041 71.4286 µM 0.423918685027438 0.314166209499968 no 1080 0.335812558386353 1576 16004211
SGTC_2879 9041815 71.43 µM 0.423193610995906 0.314435871922137 no 1081 0.33607700391934 1562 4942971
SGTC_857 0438-0306 1.35 µM 0.421796422444049 0.314955779802174 no 1082 0.33658680861346 1602 4686136
SGTC_1830 st055982 50.3 µM 0.420562082743659 0.315415395286953 no 1083 0.337037443245967 1694 455313 An antimicrobial agent.
SGTC_173 1273-0061 2.693 µM 0.420348681538924 0.315494885790345 no 1084 0.337115375825296 1520 2847414 YPL266W DIM1
SGTC_1757 st041620 31.8375 µM 0.42026124415492 0.315527458089986 no 1085 0.337147309345923 1571 5289815
SGTC_1808 st050063 61.5 µM 0.419767452138342 0.315711433097686 no 1086 0.337327672049181 1662 4011993
SGTC_1114 scopoletin 1.73284 µM 0.418108597843902 0.316329816479852 no 1087 0.337933859520513 1705 5280460 A coumarin with genotoxic properties.
SGTC_730 1436-0052 41.2 µM 0.414988683559574 0.317494241386061 no 1088 0.33907509368247 1612 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_285 1486-1325 46 µM 0.414186741430124 0.317793837510046 no 1089 0.339368675512028 1656 22310230
SGTC_2683 piperine 63.03 µM 0.413315937053075 0.318119294896844 no 1090 0.339687577469138 1601 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3347 9188721 44.724 µM 0.41316654046741 0.318175145009904 no 1091 0.339742300339321 1632 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_416 estradiol valerate 100 µM 0.409693129594298 0.319474801012221 no 1092 0.341015535289032 1620 13791 A steroid.
SGTC_2290 7904846 200 µM 0.409233581735773 0.319646918018118 no 1093 0.341184126081016 1586 2962154
SGTC_2080 5212524 12.4 µM 0.408694954960155 0.319848702342966 no 1094 0.341381768308207 1726 260183
SGTC_1824 st053723 68.6 µM 0.408485558750523 0.319927162288777 no 1095 0.341458615325984 1556 675225
SGTC_850 0388-0143 75.9 µM 0.407587726987793 0.320263667648921 no 1096 0.341788188100147 1586 67273
SGTC_1526 st051518 75 µM 0.406953571637408 0.32050143679628 no 1097 0.342021044212322 1602 673993
SGTC_2116 5511452 16.8835 µM 0.404055067673121 0.321589133921898 no 1098 0.34308611261735 1645 870744
SGTC_2086 5274770 176.623 µM 0.403955374953416 0.321626572057957 no 1099 0.343122767403455 1621 689278
SGTC_2818 7996756 12.99 µM 0.403677998007004 0.321730746425515 no 1100 0.34322476047699 1591 2241621
SGTC_2300 7976697 71.57 µM 0.403623098666316 0.321751366614527 no 1101 0.343244948629506 1554 2236109
SGTC_1740 st038286 13.222 µM 0.402914975885162 0.322017386681737 no 1102 0.343505386931725 1650 716786
SGTC_2310 7668677 200 µM 0.399417119247954 0.323332760499838 no 1103 0.344792940979754 1675 2197143
SGTC_1096 rimcazole 32.2 µM 0.399127151030815 0.323441902928285 no 1104 0.344899758682175 1631 18528119 A dopamine reuptake inhibitor.
SGTC_1130 3454-2858 15.9 µM 0.395219866258247 0.324914061747038 no 1105 0.346340316243824 1583 715628 YIL048W NEO1
SGTC_1455 4262-0120 131 µM 0.394985332253389 0.32500251513214 no 1106 0.346426856441614 1713 1529587
SGTC_1960 st011366 51.8 µM 0.394798434242976 0.325073009891568 no 1107 0.346495825276556 1620 3972846
SGTC_2321 7390090 138.78 µM 0.394277878911275 0.3252693875385 no 1108 0.346687946676976 1564 649046
SGTC_2770 toltrazuril 17.5 µM 0.394119465129475 0.32532915820866 no 1109 0.346746420293406 1730 68591 Kills coccidiodes.
SGTC_3141 9094609 49.47 µM 0.393898372967594 0.325412585398499 no 1110 0.346828035825455 1577 25236309 YDL196W YDL196W
SGTC_1882 5615643 20 µM 0.393247010211053 0.325658422270815 no 1111 0.347068525808178 1602 2253075
SGTC_610 4215-0184 155 µM 0.392062823913205 0.326105551256188 no 1112 0.347505897603964 1661 5605015
SGTC_2331 7980721 200 µM 0.390899424150017 0.32654507519041 no 1113 0.347935789817784 1736 2981221
SGTC_849 0386-0493 241 µM 0.390834694642454 0.326569536605445 no 1114 0.347959714008301 1618 726119
SGTC_113 0099-0221 2.5 µM 0.389701578123936 0.326997864387602 no 1115 0.348378614712388 1744 89219
SGTC_2685 mycophenolic acid 18.85 µM 0.386281731908926 0.328291976316705 no 1116 0.34964401420196 1708 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2883 9059145 45.46 µM 0.385600173671452 0.328550133407362 no 1117 0.349896402292107 1613 16476510
SGTC_355 1311-2252 105 µM 0.38286252507438 0.329587909478398 no 1118 0.350910849368158 1607 5338538
SGTC_2444 5485484 36.41 µM 0.382657949763666 0.32966551185565 no 1119 0.350986698399944 1716 6790631
SGTC_414 piperonyl butoxide 100 µM 0.382003493784642 0.329913818528097 no 1120 0.351229386574085 1609 5794 A potent inhibitor of cytochrome P450.
SGTC_2757 clomiphene 4.22 µM 0.380605198519867 0.330444595805436 no 1121 0.351748111637882 1797 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_282 k297-0036 65.7 µM 0.380198748427026 0.330598943787854 no 1122 0.351898944112122 1697 5061378
SGTC_1554 st069299 38.7 µM 0.379882069250874 0.330719221555105 no 1123 0.352016479011542 1702 24207999
SGTC_711 k292-0785 179 µM 0.379458272007205 0.330880211133634 no 1124 0.35217379270873 1613 4146315
SGTC_1001 4048-4355 44.4 µM 0.377758775966008 0.331526119582198 no 1125 0.352804900198438 1614 21824233
SGTC_2238 6671620 73.2395 µM 0.377352279450898 0.331680686534012 no 1126 0.352955912715628 1572 729941
SGTC_248 streptozotocin 5.23457 mM 0.375399756609921 0.332423516340964 no 1127 0.353681592941052 1752 5300 DNA alkylating agent.
SGTC_602 3130-1533 38.1 µM 0.373936094759957 0.332980793007428 no 1128 0.3542259307649 1758 720941
SGTC_1736 st036774 51 µM 0.373811565955042 0.33302822333271 no 1129 0.354272256966006 1852 1272247
SGTC_686 1319-0111 510 µM 0.373156407331234 0.33327780304675 no 1130 0.354516019294573 1768 4562600
SGTC_1888 azatryptophan 97.5 µM 0.372144562481617 0.333663405820286 no 1131 0.354892609559334 1639 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2174 5790901 200 µM 0.371857787341757 0.333772724608796 no 1132 0.354999367864651 1659 786020
SGTC_2517 totarol 10 µM 0.3705322343746 0.334278209124734 no 1133 0.355492981709388 1608 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_608 k048-0125 159 µM 0.370390194240595 0.334332392362509 no 1134 0.355545889487479 1766 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_869 0564-0080 44.1 µM 0.370351318692395 0.334347222597297 no 1135 0.355560370519986 1627 6843321
SGTC_2125 5246583 200 µM 0.367550210323993 0.335416467956315 no 1136 0.356604323067411 1844 835267
SGTC_1312 1218-2183 165 µM 0.364142430623037 0.336719092216802 no 1137 0.35787582680797 1719 6744073
SGTC_1523 st012844 44.7 µM 0.362692533845203 0.337273911191964 no 1138 0.358417288815667 1690 4274103
SGTC_3051 9093778 49.47 µM 0.362643969070972 0.337292501172636 no 1139 0.358435430200704 1711 17217378
SGTC_2827 7993847 71.43 µM 0.360933165545501 0.337947628283639 no 1140 0.359074704940147 1705 2985692
SGTC_2663 amphotericin b 100 µM 0.360418070189282 0.338144972785586 no 1141 0.359267257671967 1695 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1427 4048-4900 550 nM 0.360364683637139 0.338165428907473 no 1142 0.359287216656134 1785 24132586
SGTC_2096 5468907 200 µM 0.35638317064469 0.339692367846729 no 1143 0.360776815499691 1821 759785
SGTC_1697 st025554 27.742 µM 0.353924113872726 0.340636751723691 no 1144 0.361697877471194 1667 1269519
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.352677794191128 0.341115774450441 no 1145 0.362165004327094 1691 689007
SGTC_2566 crystal violet carbinol 226 nM 0.352500016800919 0.341184124051538 no 1146 0.362231652934236 1593 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2666 tannic acid 100 µM 0.351835044620892 0.341439830324652 no 1147 0.362480987509686 1722 16134267 A thiamine antagonist.
SGTC_3010 9080089 71.4286 µM 0.350940919102511 0.34178376923384 no 1148 0.362816336196574 1779 17027233
SGTC_940 3232-1287 54.8 µM 0.350614135273154 0.341909504374262 no 1149 0.362938925271267 1790 1585493 YIL048W NEO1
SGTC_3335 9143315 29.6265 µM 0.35051543611245 0.341947483854019 no 1150 0.362975953852302 1682 4899691
SGTC_592 k241-0073 46.5 µM 0.35035331349054 0.342009872180246 no 1151 0.363036779547287 1790 4230158
SGTC_1423 4048-0112 5.59 µM 0.350219388579654 0.342061412665098 no 1152 0.363087028538865 1791 X1423
SGTC_2296 7971656 126.45 µM 0.349443511185192 0.342360063970036 no 1153 0.363378186206608 1664 666570
SGTC_466 geldanamycin 89.2 µM 0.348802259405947 0.342606969518967 no 1154 0.3636188835309 1792 5288382 HSP90 inhibitor.
SGTC_353 1988-1175 58.3 µM 0.347424373060982 0.343137733934146 no 1155 0.364136262657837 1640 2788357
SGTC_2248 tofa 1.1 µM 0.346831470592365 0.34336621642207 no 1156 0.364358966420815 1735 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1734 st037168 69.4 µM 0.346521949078438 0.343485517217056 no 1157 0.364475245911348 1684 708907
SGTC_2489 cantharidin 73.42 µM 0.346036652493198 0.34367259947568 no 1158 0.364657584803622 1654 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1466 k213-0079 57.5 µM 0.345667706777886 0.343814853997727 no 1159 0.364796228057757 1713 3657981
SGTC_3256 9138902 49.47 µM 0.342522432886036 0.345028474389186 no 1160 0.365978882417033 1789 17228773
SGTC_1739 st037196 92.5 µM 0.340527490695269 0.345799061258345 no 1161 0.366729661933747 1857 612214
SGTC_530 4358-1714 28 µM 0.338714031780358 0.346500101324879 no 1162 0.367412584525959 1775 1564641
SGTC_1313 1220-0047 237 µM 0.338286629130473 0.3466654017141 no 1163 0.367573599403222 1769 3528706
SGTC_1963 st076565 50.3 µM 0.337526937855905 0.34695928866048 no 1164 0.367859854420237 1690 4914280
SGTC_3176 9106582 49.47 µM 0.336923289729085 0.347192875904268 no 1165 0.368087364039811 1799 17018027
SGTC_1939 st074455 53.6 µM 0.336562468420964 0.347332526789004 no 1166 0.368223376489464 1852 1644229
SGTC_3167 9103034 49.47 µM 0.334969422894163 0.347949340533795 no 1167 0.368824076029793 1742 5127859
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.333620568510935 0.348471920358044 no 1168 0.369332947633932 1760 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_266 formosanin C 406 nM 0.33256445397937 0.348881286362496 no 1169 0.369731539511935 1757 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_873 0591-4978 488 µM 0.330831519218591 0.34955337923677 no 1170 0.370385875669655 1896 3305145
SGTC_2100 5377183 190 µM 0.330563488267609 0.349657373227917 no 1171 0.370487114613883 1834 2844202
SGTC_142 0335-0849 62.6745 µM 0.329936921338976 0.349900520482786 no 1172 0.370723812468176 1744 3889043 YPR107C YTH1
SGTC_1878 temozolomide 1 mM 0.328844959709064 0.350324417155529 no 1173 0.37113643914126 1878 5394 DNA alkylating agent.
SGTC_88 0180-0332 8.668 µM 0.328842268404694 0.350325462143522 no 1174 0.371137456305275 1748 3101745
SGTC_206 4546-0025 72.014 µM 0.328790220764827 0.350345671585085 no 1175 0.371157127607933 1755 6620745 YIL048W NEO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.328658961875748 0.350396639636353 no 1176 0.371206738140592 1702 688803
SGTC_2206 7254556 146.969 µM 0.327711479983289 0.350764628333134 no 1177 0.37156491127663 1816 4398905
SGTC_2045 5106652 78.05 µM 0.32671600126552 0.351151409199888 no 1178 0.371941348297778 1813 673349
SGTC_1160 4092-0570 10.5 µM 0.326625596857156 0.351186542353172 no 1179 0.371975540499297 1665 4994975
SGTC_2699 st077704 54.6 µM 0.325369406258796 0.351674857315066 no 1180 0.372450753586616 1742 645852
SGTC_3038 9091290 49.47 µM 0.324575696419759 0.351983519879581 no 1181 0.372751111802772 1823 25236843
SGTC_1003 4049-0218 100 µM 0.324158640313144 0.352145746232135 no 1182 0.372908966534608 1810 295161
SGTC_3251 9135047 49.47 µM 0.324132011875342 0.352156105067714 no 1183 0.372919046059276 1843 17682963
SGTC_1318 1280-3875 124 µM 0.323561076757264 0.35237823321183 no 1184 0.373135180092002 1776 373245
SGTC_3331 9141060 1.957 µM 0.322976403386429 0.352605758557644 no 1185 0.373356556280707 1697 4906567 YPR165W RHO1
SGTC_1235 benzylparaben 21.5 µM 0.322833157788411 0.352661510556137 no 1186 0.373410800061339 1756 7180
SGTC_1459 k035-0031 35.7 µM 0.322510089886188 0.35278726203058 no 1187 0.3735331475788 1642 3877128 YMR208W ERG12
SGTC_2588 indole-3-carbinol 100 µM 0.320498714386855 0.353570534430755 no 1188 0.374295152390618 1886 3712 Induces cell cycle arrest.
SGTC_2946 9065502 71.43 µM 0.319841468927415 0.353826614445147 no 1189 0.374544254916441 1735 16489101
SGTC_3325 9138760 55.175 µM 0.319159797058555 0.354092281509923 no 1190 0.37480267061772 1705 43844959
SGTC_1633 st005664 67.9 µM 0.319131584878348 0.354103278136895 no 1191 0.374813366815041 1700 2063822
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.318523574972816 0.354340299589205 no 1192 0.375043907444589 1725 16486 A toxic proline analog.
SGTC_700 3453-2283 142 µM 0.318456127764785 0.354366596118525 no 1193 0.375069484323159 1809 565664
SGTC_733 4069-0007 56.1 µM 0.318281232546231 0.354434788049909 no 1194 0.375135809475764 1786 5717425 YNL287W SEC21
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.317931890400791 0.354571011091043 no 1195 0.375268300827236 1795 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_291 SEC14.278 35.5 µM 0.317767596497989 0.35463508255387 no 1196 0.375330615950807 1840 1068044
SGTC_2570 licareol 100 µM 0.315522538458574 0.355511023428647 no 1197 0.376182470573007 1715 443158
SGTC_394 menadione 8.33 µM 0.313814964901384 0.35617776883454 no 1198 0.37683078889611 1862 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1085 doxorubicin 7.67 µM 0.313576102512586 0.356271071038864 no 1199 0.376921506064579 1846 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2456 5770359 74.46 µM 0.312443443649176 0.356713616771081 no 1200 0.377351769208369 1847 3118787
SGTC_1214 0358-0031 63.7 µM 0.312026467597467 0.35687658379396 no 1201 0.377510204287923 1914 4301366
SGTC_35 0133-0054 64.071 µM 0.310752525758729 0.357374641028201 no 1202 0.377994381450934 1676 99677
SGTC_244 nsc-207895 1.295 µM 0.309642181832555 0.357808936697837 no 1203 0.378416537618513 1722 42640
SGTC_3271 9137798 49.47 µM 0.309191257390809 0.357985362161447 no 1204 0.378588021949253 1884 6498326
SGTC_360 0957-0399 1.01 µM 0.308738397173184 0.358162575534238 no 1205 0.378760266510446 1860 6752301 YPR165W RHO1
SGTC_788 1182-0090 188 µM 0.308036095566189 0.358437460810366 no 1206 0.379027433275779 1905 5715185
SGTC_2231 micatex 6.853 µM 0.307621281158769 0.358599856260441 no 1207 0.379185262473116 1794 20737 An antifungal of unknown mechanism.
SGTC_384 k007-0144 5.16 µM 0.306538762665098 0.359023771163702 no 1208 0.379597235507464 1782 6824886
SGTC_356 1634-0012 32.5 µM 0.305756068846892 0.359330382747794 no 1209 0.379895189744083 1939 735457
SGTC_1017 4239-0030 168 µM 0.304857121793865 0.359682647028406 no 1210 0.380237486995247 1694 1149593
SGTC_807 1315-0151 48 µM 0.304700596568584 0.359743995703874 no 1211 0.380297097604764 1918 4011080
SGTC_1231 0242-0792 125 µM 0.30393187704114 0.360045340945684 no 1212 0.380589895747134 1729 3707635
SGTC_3022 9087993 49.47 µM 0.300388316498422 0.361435572018496 no 1213 0.381940487259797 1825 17173644
SGTC_2891 9063876 19.48 µM 0.300085144160884 0.361554599729933 no 1214 0.382056105280297 1938 6472478
SGTC_502 l-744,832 89.3 µM 0.300053829043867 0.361566895041117 no 1215 0.382068048235372 1902 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_435 c-PAF 6.7 µM 0.29992677864109 0.361616780537486 no 1216 0.382116503851859 1910 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_724 3910-0327 137 µM 0.298459413453723 0.362193101991484 no 1217 0.382676274315151 1732 2885483
SGTC_2779 methotrexate 400 µM 0.2980220266163 0.362364950301898 no 1218 0.38284317613109 1858 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_278 4092-0821 23.9 µM 0.297752328770823 0.362470927810028 no 1219 0.382946100591001 1850 877900
SGTC_2718 lomofungin 53.02 µM 0.297570666907117 0.362542317604969 no 1220 0.383015432645714 1891 5351222 A RNA synthesis inhibitor.
SGTC_264 promethazine 12.5 mM 0.296890993810134 0.362809459094966 no 1221 0.38327486612006 1907 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1838 st055369 84.5 µM 0.295647995042711 0.363298185077091 no 1222 0.3837494582215 1764 676036
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.295034109785168 0.363539636499956 no 1223 0.383983911497263 1748 803109
SGTC_2968 9090663 33.37 µM 0.294334251178887 0.363814968824348 no 1224 0.384251251265244 1789 25236811
SGTC_351 caspofungin 25 nM 0.29367312155653 0.364075129334956 no 1225 0.384503847495837 1837 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3137 9097352 49.47 µM 0.293473314248348 0.364153767660136 no 1226 0.384580197057552 1857 44120435
SGTC_613 3914-0030 117 µM 0.293425434425402 0.364172612610771 no 1227 0.384598493367217 1809 1145395
SGTC_1306 1185-0270 9.02 µM 0.293271930762133 0.364233032110835 no 1228 0.384657153432286 1878 1548076
SGTC_182 3448-4371 550.524 µM 0.293016683752512 0.364333505565208 no 1229 0.384754699661689 1988 3491403
SGTC_973 1325-0077 65.9 µM 0.29257432727001 0.364507653418395 no 1230 0.384923769679185 1891 2835149
SGTC_1446 4239-0190 62 µM 0.292415387875234 0.364570231853587 no 1231 0.384984522153424 1764 1340085
SGTC_217 ketoconazole 989 nM 0.291990078290855 0.3647377046754 no 1232 0.385147104980804 1816 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3333 9141820 12.094 µM 0.291763943299207 0.364826759655786 no 1233 0.385233557685619 1755 1939433
SGTC_1927 st060202 13.8 µM 0.291719320562216 0.364844333547412 no 1234 0.385250617887984 1930 688887
SGTC_1955 wogonin 32.4 µM 0.291397461690682 0.364971100494608 no 1235 0.385373677818593 1882 5281703 A flavanone.
SGTC_1846 st056244 14.8 µM 0.288990723813438 0.365919482357486 no 1236 0.386294238086647 1844 5393182
SGTC_2659 sanguinarine 24.21 µM 0.287315473043394 0.366580104020918 no 1237 0.386935388062994 1815 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2832 7992762 51.95 µM 0.286336230511749 0.366966443712537 no 1238 0.387310305652841 1605 2985177
SGTC_2398 5228213 48.84 µM 0.284407814297095 0.367727653768478 no 1239 0.388048935609072 1982 80771 YMR134W ERG29
SGTC_256 clotrimazole 625 nM 0.283466100053192 0.368099568835289 no 1240 0.388409782308614 1804 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2460 5552655 174.22 µM 0.281768599266876 0.368770281935042 no 1241 0.38906047494879 1775 5401989
SGTC_2506 ethyl hematommate 54.16 µM 0.281710407357138 0.368793281706457 no 1242 0.38908278682785 1742 3940691 An allergen.
SGTC_1641 st009299 47.1 µM 0.281318667338345 0.368948125264417 no 1243 0.389232996877559 1870 4046054
SGTC_2463 5473429 200 µM 0.279336592367572 0.369731908105815 no 1244 0.389993263405097 1805 5399405
SGTC_1403 3909-7815 62.9 µM 0.27852104007626 0.370054563888686 no 1245 0.390306208056012 1813 6615483
SGTC_20 0481-0013 4.944 µM 0.27690535123535 0.370694046487185 no 1246 0.390926391758503 1772 182045
SGTC_2539 epi(13)torulosol 80 µM 0.27688072634247 0.37070379568179 no 1247 0.390935846198067 1762 6708597
SGTC_2702 st077768 96.8 µM 0.276566149264876 0.370828346597953 no 1248 0.391056630056989 1781 6484119
SGTC_629 3448-6466 76.7 µM 0.275297531179777 0.371330769466885 no 1249 0.391543830526295 1833 573744
SGTC_3279 9140807 49.47 µM 0.275070723921976 0.371420617235806 no 1250 0.391630951607146 1818 45595718
SGTC_3099 9120367 49.47 µM 0.27329328626789 0.372124976320898 no 1251 0.392313887876337 1819 24824940
SGTC_322 k048-0136 19.3 µM 0.272857624560295 0.372297684797651 no 1252 0.392481330776646 1867 6823282
SGTC_1662 st014054 52 µM 0.272120917139215 0.372589794640621 no 1253 0.392764523331338 1904 2838777
SGTC_2058 5236698 133 µM 0.271926525517826 0.372666884559387 no 1254 0.392839257530248 1809 766665
SGTC_199 4063-0024 41.6 µM 0.271317571104753 0.372908410719662 no 1255 0.393073396679477 1911 306215
SGTC_836 0330-0104 1.35 µM 0.271239417573529 0.372939411934502 no 1256 0.393103449024547 1844 46494820
SGTC_3298 9116858 71.43 µM 0.270765493846817 0.373127421201193 no 1257 0.393285700357961 1913 2506942
SGTC_2505 galangin 7.89 µM 0.269694765161165 0.373552298871309 no 1258 0.393697544083877 1770 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1304 1165-0502 251 µM 0.269193806939064 0.373751137781135 no 1259 0.393890272890561 1871 767425
SGTC_1065 prochlorperazine maleate 2.48 µM 0.268762515943133 0.373922351498002 no 1260 0.394056220122974 1831 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_179 1273-0063 6.77 µM 0.268544935710177 0.374008735850095 no 1261 0.394139945466561 1776 3108139
SGTC_2226 7298446 200 µM 0.267525630958119 0.374413507451598 no 1262 0.39453224121997 1934 3283010
SGTC_2700 st077718 96.8 µM 0.267079187489505 0.374590836269636 no 1263 0.394704095851228 1778 904970
SGTC_2252 omeprazole 400 µM 0.26554395989609 0.375200835967241 no 1264 0.395295224909791 1913 4594 A proton pump inhibitor.
SGTC_517 1365-0151 113 µM 0.26497474471641 0.375427084524306 no 1265 0.395514458706786 1854 768657
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.264929433365049 0.375445096476481 no 1266 0.395531911841023 1851 65057 A dermal irritant. YDR527W RBA50
SGTC_3168 9103419 49.47 µM 0.264638985967656 0.375560560186748 no 1267 0.395643792035711 1936 16649256
SGTC_1315 1237-0019 3.69 µM 0.264272316672978 0.375706340870902 no 1268 0.395785045147934 1935 825140
SGTC_1913 st060213 96.1 µM 0.264271132190901 0.37570681182704 no 1269 0.395785501471708 1961 688959
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.263432777143667 0.376040192496185 no 1270 0.396108515000568 1914 66535 A nucleotide analog.
SGTC_2062 5245942 200 µM 0.262121512672353 0.376561816020771 no 1271 0.396613880880713 1892 1376160
SGTC_1733 st037357 54.9 µM 0.261854243566636 0.376668163877341 no 1272 0.396716908662432 1714 1272339 YGL099W LSG1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.26165458020614 0.376747617142374 no 1273 0.396793880263001 1721 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_93 0109-0045 59.227 µM 0.261125586798408 0.376958147963085 no 1274 0.396997830298145 1966 88733
SGTC_1112 tnp00069 1.16933 µM 0.259861281319585 0.377461469210361 no 1275 0.397485389250927 1947 145826
SGTC_2383 9036125 200 µM 0.259107490257257 0.377761653291681 no 1276 0.397776152859515 1869 79580
SGTC_2980 9014342 25.29 µM 0.258641772011099 0.37794715433656 no 1277 0.397955825090202 1856 2996599
SGTC_2614 arthonioic acid 13.39 µM 0.257262293986089 0.378496781635028 no 1278 0.398488149039339 1843 6710684
SGTC_2312 7706453 155.7 µM 0.256873262365824 0.378651828529327 no 1279 0.398638305852028 1824 976098
SGTC_3247 9135149 49.47 µM 0.256262952352608 0.378895104335962 no 1280 0.398873901010526 1867 8934436 YOR116C RPO31
SGTC_1621 st003705 32.4 µM 0.255203379292244 0.379317574903696 no 1281 0.399283010585549 1975 24207032
SGTC_2523 spermine 47.74 µM 0.253521630601478 0.379988413735603 no 1282 0.399932574107751 1988 1103 A DNA binding polyamine.
SGTC_123 0083-0120 66.675 µM 0.253204955342218 0.380114773955777 no 1283 0.400054918727399 1782 16001701
SGTC_2908 7930301 100 µM 0.25295305337098 0.380215297384408 no 1284 0.40015224577985 1841 2223178
SGTC_3086 9117350 49.47 µM 0.252065772515271 0.380569438070307 no 1285 0.400495112740461 1862 2679265
SGTC_424 splitomicin 100 mM 0.247992597238908 0.382196446174493 no 1286 0.402070067241372 1775 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_595 3909-8003 73.7 µM 0.247857737899116 0.382250350787279 no 1287 0.402122239991454 1905 699517
SGTC_1388 3346-4487 254 µM 0.247173688570737 0.382523807200018 no 1288 0.402386903560031 1923 3345614
SGTC_684 1140-0066 328 µM 0.246350280811463 0.382853051411141 no 1289 0.402705545247423 1848 6813534
SGTC_1700 st030840 7.9285 µM 0.245758312487214 0.383089805595842 no 1290 0.402934664637501 1986 5499307
SGTC_2122 5258151 111.688 µM 0.244920369868224 0.383425010380516 no 1291 0.40325904454001 1860 2173356
SGTC_1758 st042942 75.2445 µM 0.244590522868699 0.383556984053387 no 1292 0.403386751435278 1997 669317
SGTC_2457 5731572 11.68 µM 0.243808391623298 0.383869973215556 no 1293 0.403689610424422 1986 2865357
SGTC_393 acivicin 6.25 µM 0.24103779366336 0.384979304812892 no 1294 0.404762912399551 1884 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2140 5586273 200 µM 0.240997959765046 0.384995260969747 no 1295 0.404778348900933 1913 854421
SGTC_1852 st056254 31.4 µM 0.238333560230888 0.38606297317521 no 1296 0.405811196933346 1914 442583
SGTC_402 epigallocatechin gallate 10 µM 0.237644336363837 0.386339308675644 no 1297 0.406078479984218 1851 65064 An antioxidant.
SGTC_1555 citronellol 128 µM 0.236340332354885 0.386862290057812 no 1298 0.406584296270859 2018 8842 A terpine precursor.
SGTC_2747 doxorubicin 7.63 µM 0.236302462314518 0.386877481219716 no 1299 0.406598988193657 1992 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3065 9113888 49.47 µM 0.235920405958215 0.387030748733226 no 1300 0.406747216735403 1952 16648368
SGTC_91 0417-1751 58.384 µM 0.234739040929431 0.387504782003127 no 1301 0.407205641975615 2010 6795624
SGTC_375 3970-0961 9.27 µM 0.233968761905904 0.387813953739367 no 1302 0.407504615010592 1907 2898222
SGTC_1820 st053765 18.6 µM 0.233921625734596 0.3878328753926 no 1303 0.407522912007892 1845 3690829
SGTC_1839 st053978 48 µM 0.23199950352896 0.388604690338154 no 1304 0.408269199705076 2014 3788398
SGTC_9 0092-0002 10.449 µM 0.231962452502469 0.388619572254818 no 1305 0.408283588502347 1933 759368
SGTC_1895 st058434 18.3 µM 0.231746314763592 0.388706389404679 no 1306 0.408367528239102 2024 5393175
SGTC_3210 9128157 49.47 µM 0.231289871998718 0.388889749362761 no 1307 0.408544807185222 1757 17590849
SGTC_1115 galangin 695.678 nM 0.230093165370909 0.389370601929342 no 1308 0.409009687836104 2003 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3297 9117502 71.43 µM 0.230086811737891 0.389373155356049 no 1309 0.409012156353049 2005 7453720
SGTC_279 1273-0055 2.93 µM 0.229875385503913 0.389458127008412 no 1310 0.409094301845588 2024 2847562
SGTC_2910 7948405 25.97 µM 0.228412863883029 0.390046055160805 no 1311 0.409662644913911 2015 2971328
SGTC_1428 4049-0204 61.7 µM 0.227536702433584 0.390398389354147 no 1312 0.410003216575242 1996 X1428
SGTC_2843 9000894 45.46 µM 0.226053645227004 0.390994981923207 no 1313 0.410579848569081 1924 2242070
SGTC_1654 st012436 41.8 µM 0.22587325193549 0.391067566648296 no 1314 0.410650001048164 2008 4323132
SGTC_234 nsc-17383 10.7 µM 0.225546533329436 0.391199037848122 no 1315 0.410777064712297 1979 408974
SGTC_2519 cryptotanshinone 88.04 µM 0.225491737497302 0.391221088847224 no 1316 0.410798376197985 1978 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2401 5128683 200 µM 0.225265040328062 0.39131232028651 no 1317 0.410886547261074 1835 708373
SGTC_1807 st050092 58.9 µM 0.224652424987482 0.391558889565945 no 1318 0.411124838941687 1915 5008496
SGTC_624 k048-0052 28 µM 0.22447405613573 0.391630688779277 no 1319 0.411194226026204 1918 6835531
SGTC_400 oxethazaine 37.5 µM 0.223651431998925 0.391961869253126 no 1320 0.411514270120454 1895 4621 A local anesthetic.
SGTC_196 k015-0023 18.111 µM 0.222804982382973 0.392302723359658 no 1321 0.411843645048735 1885 5211998
SGTC_803 4488-1585 147 µM 0.222693951863218 0.392347440023765 no 1322 0.411886854442507 2003 747204
SGTC_2269 7935389 174.42 µM 0.222126705054195 0.392575916362143 no 1323 0.41210762473826 1830 97605
SGTC_1281 0884-0031 11.8 µM 0.220162574292706 0.393367316865003 no 1324 0.412872271443512 1879 1548255
SGTC_1135 dihydrocapsaicin 536.708 nM 0.220101866350808 0.393391784748033 no 1325 0.41289591065643 1786 107982 A Capsaicinoid.
SGTC_2371 9071574 200 µM 0.219619855792572 0.393586070442654 no 1326 0.413083613121648 2008 45596039
SGTC_2809 7964133 12.99 µM 0.219306031368113 0.393712579004203 no 1327 0.413205831953642 1920 1253665
SGTC_338 4055-0136 114 µM 0.216953174951756 0.394661416434826 no 1328 0.414122418368344 1876 2900563
SGTC_1924 st058459 75.1 µM 0.21472313514089 0.395561302829539 no 1329 0.41499159201718 1970 688683
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.214317498123903 0.395725049272283 no 1330 0.415149736757239 1979 4000243
SGTC_3122 9126309 49.47 µM 0.212800729822324 0.396337497025392 no 1331 0.415741197232975 2074 17591206
SGTC_3050 9093513 49.47 µM 0.212422831560716 0.39649012642113 no 1332 0.41588858759435 1947 25236664
SGTC_536 3852-0578 10.6 µM 0.212230335620446 0.396567879740345 no 1333 0.415963670674837 2045 2869208
SGTC_2255 7941087 197.44 µM 0.211249338410063 0.396964189794627 no 1334 0.41634635642821 2050 935561
SGTC_448 monastrol 171 µM 0.210292697560011 0.397350762705406 no 1335 0.416719617184176 2008 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2073 5212005 126 µM 0.209178880416123 0.397800976673004 no 1336 0.417154299358399 2085 691789
SGTC_3327 9140648 26.9345 µM 0.208913940648133 0.397908087551775 no 1337 0.417257710610026 2027 8029710
SGTC_1171 0368-0077 21.4 µM 0.208297031272711 0.398157523878991 no 1338 0.41749852475685 1912 3239779
SGTC_2863 9028737 58.44 µM 0.207886466433915 0.398323551541108 no 1339 0.417658808275602 2077 6460917
SGTC_1892 st058411 7.36 µM 0.207285171819925 0.39856674132778 no 1340 0.417893576919922 2043 3934738
SGTC_1185 1319-0113 81.3 µM 0.207047921701852 0.398662706474094 no 1341 0.417986216586126 1976 4672763
SGTC_1884 5633444 25 µM 0.202219284461387 0.40061716246408 no 1342 0.419872648867336 1975 5724239
SGTC_2951 9072950 58.06 µM 0.202129429348064 0.400653556288914 no 1343 0.419907770693047 2069 16488155
SGTC_444 curcumin 90.4 µM 0.201666372891625 0.400841120724638 no 1344 0.420088776490303 2009 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2603 homopterocarpin 100 µM 0.201393542459187 0.400951643411143 no 1345 0.420195432071719 1922 101795 A weak amylase inhibitor.
SGTC_1371 2421-0008 32.7 µM 0.200235682680977 0.401420776610859 no 1346 0.420648130743322 1912 2827552
SGTC_2382 9035899 200 µM 0.199054907851052 0.401899340748287 no 1347 0.421109896815954 1920 6462679
SGTC_1659 st012954 42.1 µM 0.19778447723176 0.402414406378837 no 1348 0.421606845817023 2013 24207262
SGTC_1239 0337-0584 35.4 µM 0.197599458936258 0.402489431768053 no 1349 0.421679229081794 2068 914301 YML130C ERO1
SGTC_2576 guaiol 23.12 µM 0.197269672022092 0.402623170105224 no 1350 0.42180825560505 2092 227829
SGTC_318 1488-0629 67.2 µM 0.196597028707891 0.402895982153382 no 1351 0.422071447991409 1939 3662576
SGTC_2778 tioconazole 65.09 nM 0.195496499665957 0.403342438876063 no 1352 0.422502138839009 1981 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1540 guanosine 70.6 µM 0.193768586345546 0.404043663521279 no 1353 0.423178542628881 2064 6802 Guanosine is a purine nucleoside
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.192498691907196 0.404559210969576 no 1354 0.423675796228825 1982 6708739 YPR165W RHO1
SGTC_1855 st056195 39.6 µM 0.192238576413461 0.404664832259288 no 1355 0.423777664890958 2080 4028379
SGTC_1268 0828-0275 2.46 µM 0.192034716357788 0.404747615583277 no 1356 0.423857505876551 2013 745337
SGTC_3278 9139605 49.47 µM 0.191836093265319 0.404828276386276 no 1357 0.423935298832496 2037 7958859
SGTC_294 k038-0071 157 µM 0.190984301740864 0.405174234592584 no 1358 0.424268946087819 1958 24152826
SGTC_1397 3532-0190 20.1 µM 0.189344804635041 0.405840330655744 no 1359 0.424911290682291 1984 5322280
SGTC_328 k915-0120 63.5 µM 0.188796653112065 0.40606309497611 no 1360 0.42512609755006 2067 6624543
SGTC_1656 st012921 11 µM 0.185792822867937 0.407284365350827 no 1361 0.426303616531558 2043 6732821
SGTC_2728 chlorpromazine 9.18 µM 0.185289637937456 0.407489034280857 no 1362 0.426500932518844 2064 2726 A thorazine and dopamine antagonist.
SGTC_1862 st057513 3.81 µM 0.184121004849227 0.407964469563803 no 1363 0.426959264342733 1980 5393163
SGTC_1743 st037606 46.3785 µM 0.183798515693611 0.408095691798794 no 1364 0.427085760303325 1974 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2344 7990960 76.95 µM 0.182807838585492 0.408498867020324 no 1365 0.427474398978681 1947 140813
SGTC_2759 disulfiram 3.38 µM 0.182000174103657 0.408827633410479 no 1366 0.427791294634039 1977 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_208 k072-0098 12.366 µM 0.18167936319001 0.408958239916606 no 1367 0.427917181108873 2104 5948901
SGTC_130 0136-0219 337.655 µM 0.18163404422646 0.408976690701072 no 1368 0.427934964900399 2116 234244
SGTC_809 3998-0021 90 µM 0.179257306934569 0.409944617394801 no 1369 0.428867833970226 2109 715485
SGTC_2051 5263410 176 µM 0.178761737418168 0.41014650753651 no 1370 0.429062395194594 2118 227584
SGTC_1492 4158-0558 28.5 µM 0.178252773884326 0.410353879061987 no 1371 0.429262232868679 2085 3967268
SGTC_2291 7917025 104.35 µM 0.177540165507634 0.410644265518817 no 1372 0.429542059399264 1928 2964612
SGTC_2011 4012611 177 µM 0.176428820393765 0.411097234096982 no 1373 0.429978532189244 1964 2049887
SGTC_1912 st060209 90.8 µM 0.175357566771734 0.411533974181473 no 1374 0.430399340353808 1951 688787
SGTC_2762 leflunomide 42.06 µM 0.174823701175223 0.41175166716116 no 1375 0.430609082144404 1964 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_137 0438-0332 85.389 µM 0.173228049286631 0.412402483644634 no 1376 0.431236088389332 2078 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_581 0958-0271 211 µM 0.171949199362592 0.412924260542069 no 1377 0.431738733532443 1973 4591145
SGTC_270 tamoxifen 5.46 µM 0.171049130810257 0.413291585140551 no 1378 0.432092567003569 2122 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_971 1315-0384 26.7 µM 0.170705352183648 0.413431903778988 no 1379 0.432227727085647 1941 6769120
SGTC_926 2268-1401 59.4 µM 0.170186361501013 0.413643758907025 no 1380 0.432431788600402 2122 2931578
SGTC_2596 sinensetin 100 µM 0.16961382652719 0.413877500300384 no 1381 0.432656924058213 1981 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2781 5567276 71.43 µM 0.168647445020303 0.41427210146704 no 1382 0.433036979649139 2056 2853274
SGTC_2115 tiliquinol 12.7705 µM 0.167012883909756 0.414939736254718 no 1383 0.433679955707927 2042 71208 A bioactive hydroxyquinoline.
SGTC_855 0428-0020 25 µM 0.166496182423917 0.415150833649653 no 1384 0.433883243613788 1986 6812414
SGTC_369 0957-0393 4.5 µM 0.166070412497896 0.415324799544399 no 1385 0.434050769102742 1948 6997992
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.164809826509568 0.415839961244255 no 1386 0.434546834688712 2112 688798
SGTC_1781 st038725 66.3 µM 0.164103423453911 0.416128709176394 no 1387 0.434824863412344 1931 4270275 YIL048W NEO1
SGTC_3240 9133527 49.47 µM 0.163844738152971 0.416234460208454 no 1388 0.434926685798489 2007 17617455
SGTC_755 1995-0008 37.3 µM 0.163180688695136 0.416505952608353 no 1389 0.435188085295397 2114 689533
SGTC_2292 7671323 168.05 µM 0.163099058876149 0.416539329192961 no 1390 0.435220220391881 1989 937504
SGTC_2036 5160441 105 µM 0.163048385944205 0.416560048510148 no 1391 0.435240168949254 2043 134534 YIL048W NEO1
SGTC_1499 4480-0877 67.3 µM 0.162786517476969 0.416667125854541 no 1392 0.435343262079848 2105 2861909
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.162120368631685 0.416939540261771 no 1393 0.435605533264714 2081 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1883 5-benzylidenerhodanine 20 µM 0.161785142316473 0.417076642553087 no 1394 0.435737526805277 2125 1273210
SGTC_1179 1021-1431 9.29 µM 0.161449803608196 0.417213800901137 no 1395 0.435869571762414 2041 2840958
SGTC_364 0083-0097 67.7 µM 0.161130659410705 0.417344344819059 no 1396 0.435995246512836 2014 5207356
SGTC_1337 1486-1011 40.3 µM 0.161005961725438 0.417395354095856 no 1397 0.436044352563366 2141 X1337
SGTC_878 0828-0289 13.7 µM 0.160346083273318 0.417665309436467 no 1398 0.436304229633394 1980 745350 YLR208W SEC13
SGTC_2485 5633444 17.78 µM 0.160242255137649 0.417707788916356 no 1399 0.436345122324543 1980 5724239
SGTC_2428 5615643 7.78 µM 0.159564600805383 0.417985062991157 no 1400 0.436612033044027 2073 2253075
SGTC_2868 9035608 32.47 µM 0.157989860391182 0.418629552693797 no 1401 0.437232394302243 2109 6462614
SGTC_1132 3456-3614 2.5 µM 0.157747765834248 0.418728653490013 no 1402 0.437327779991967 2151 3125502
SGTC_2560 caryophyllene 100 µM 0.157100620256911 0.418993586204615 no 1403 0.437582774379261 2151 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2009 4012297 12.05 µM 0.156818707594222 0.419109008960448 no 1404 0.437693864371275 1979 45595307
SGTC_1300 1094-0077 113 µM 0.156112814614773 0.419398051377004 no 1405 0.43797204880327 2014 5532636
SGTC_67 0335-0847 266 µM 0.156040661102565 0.419427598571392 no 1406 0.438000485414871 2152 4552207 YOR254C SEC63
SGTC_2858 9025781 8.96 µM 0.153730587509766 0.420373823547609 no 1407 0.438911083056358 2128 4894980 YPL153C RAD53
SGTC_1361 1608-0041 5.61 µM 0.150960215285127 0.421509197252238 no 1408 0.440003549882087 2047 X1361
SGTC_1865 st057639 52.2 µM 0.149955850222911 0.421920975055375 no 1409 0.440399723861947 2154 688818
SGTC_1772 st048439 82.2 µM 0.149719596555563 0.422017848686503 no 1410 0.440492923317714 2006 2927068 YDL195W SEC31
SGTC_577 r071-0003 38.6 µM 0.147311783626738 0.423005418210048 no 1411 0.441442965980234 2105 4568517 YMR134W ERG29
SGTC_1591 genipin 88.4 µM 0.147053161526171 0.423111521502965 no 1412 0.441545029774219 2133 442424 A DNA cross-linking agent.
SGTC_2082 5219693 150 µM 0.146316266322572 0.423413873508748 no 1413 0.44183586269034 2096 2834649
SGTC_1376 2910-0861 41.3 µM 0.145686158515752 0.423672445859959 no 1414 0.442084574342075 2118 1112859
SGTC_2254 7938975 95.19 µM 0.144916587953147 0.423988293015341 no 1415 0.442388364698496 2132 2969277
SGTC_2013 4024628 200 µM 0.144403182899552 0.424199031889084 no 1416 0.442591051781472 2085 5230760
SGTC_2906 7926292 26.41 µM 0.143453750822731 0.424588805111055 no 1417 0.442965917440872 2035 2966319
SGTC_2732 terfenadine 20 µM 0.143250452472392 0.4246722753975 no 1418 0.443046192675179 2177 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_617 3770-0098 35 µM 0.141747681225963 0.425289388115178 no 1419 0.443639655492808 2032 5962639
SGTC_731 3966-0296 387 µM 0.141253640235282 0.425492306015273 no 1420 0.443834786024745 2109 660956
SGTC_1472 k841-0093 193 µM 0.140502252249481 0.425800962096321 no 1421 0.444131586552605 2125 X1472
SGTC_57 miconazole 162.5 nM 0.139764233882296 0.426104170453016 no 1422 0.444423136545621 2107 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2865 9030313 51.95 µM 0.139048962331824 0.426398075173232 no 1423 0.444705729236918 1984 42562754
SGTC_1460 k062-0059 9.15 µM 0.138751177843005 0.426520446731282 no 1424 0.444823387562863 2118 1373085
SGTC_167 3672-0051 66.205 µM 0.136133239545055 0.427596565472506 no 1425 0.44585797538206 2128 3237971
SGTC_3077 9117319 49.47 µM 0.135996540237538 0.427652771389317 no 1426 0.445912008022519 2179 17154678
SGTC_565 1418-0001 44.5 µM 0.135319315418182 0.427931243897917 no 1427 0.446179707021422 2145 2862145
SGTC_2963 9082507 9 µM 0.135237139308344 0.42796503687579 no 1428 0.44621219194177 2107 16459611
SGTC_3191 9110352 49.47 µM 0.135163697832669 0.427995238389448 no 1429 0.446241224291892 2135 17122424
SGTC_697 0508-1955 564 µM 0.134475235390325 0.428278376934153 no 1430 0.446513396251186 2173 6243113
SGTC_2792 7535235 81.82 µM 0.134370989184605 0.428321252675448 no 1431 0.446554610421787 2019 1281891
SGTC_1209 2323-2347 50.3 µM 0.134125319711527 0.428422298171366 no 1432 0.446651739151387 2203 5412760
SGTC_679 0422-0091 41.4 µM 0.1301942931979 0.43003978954988 no 1433 0.448206354760121 2085 627384 YHR062C RPP1
SGTC_249 wiskostatin 11.211 µM 0.129527892594465 0.430314109237522 no 1434 0.448469977876381 2177 2775510 A n-wasp and actin depolymerizer.
SGTC_1401 3807-4679 7.6 µM 0.126152589451077 0.431704045846282 no 1435 0.449805569792971 2156 3291456
SGTC_2763 lisinopril 49.32 µM 0.124894708532965 0.432222253582889 no 1436 0.450303453774851 2206 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2203 7227154 166.4 µM 0.124799819208599 0.432261349769097 no 1437 0.450341015262189 2185 896304
SGTC_830 4076-0286 57.8 µM 0.121520193509336 0.433613022305395 no 1438 0.451639510561019 2106 6866659
SGTC_2849 9019321 12.99 µM 0.121193402829327 0.433747749389805 no 1439 0.451768924690685 2113 16489627
SGTC_1690 st023502 41.2 µM 0.119921370082984 0.434272247734245 no 1440 0.452272717880499 2192 24207482
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.119627102123444 0.434393600008251 no 1441 0.45238927475053 2058 688667
SGTC_965 1291-5240 308 µM 0.119473462426042 0.434456961475694 no 1442 0.452450131672328 2173 2834598
SGTC_1405 3909-7894 12 µM 0.11929151628822 0.434531998780606 no 1443 0.452522202263619 2198 7104060
SGTC_175 3793-3120 23.7 µM 0.119281859836692 0.434535981311384 no 1444 0.452526027319413 2100 5322297
SGTC_2030 5175110 200 µM 0.119118746844805 0.434603253662813 no 1445 0.452590639327161 2138 2831986
SGTC_1827 berberine 7.24 µM 0.118821735155483 0.434725754436799 no 1446 0.452708294255021 1984 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1259 0671-0132 43 µM 0.118065461886975 0.435037703291289 no 1447 0.453007894712147 2085 X1259
SGTC_2922 7999257 32.47 µM 0.117751096123178 0.435167385313492 no 1448 0.453132439755249 2194 2988377
SGTC_859 0439-0102 54.6 µM 0.115996581975406 0.435891284382606 no 1449 0.453827625349396 2218 610143
SGTC_1389 3405-0187 19 µM 0.115937492696669 0.43591566791841 no 1450 0.453851040582289 2066 799890
SGTC_2984 9022109 38.96 µM 0.115351453047544 0.436157513774252 no 1451 0.454083278436127 2219 6459207
SGTC_2805 7950783 58.44 µM 0.1150376152378 0.436287037653901 no 1452 0.454207653647552 2114 1178958 YDL195W SEC31
SGTC_3334 9142812 21.919 µM 0.113077737267582 0.437096052145072 no 1453 0.454984462429552 2170 45283678
SGTC_2243 6634756 200 µM 0.110078679205243 0.438334536165133 no 1454 0.456173488458066 2208 885676
SGTC_203 k066-0004 30.888 µM 0.110042162722763 0.438349619673959 no 1455 0.456187968460457 2223 6795412
SGTC_3232 9132874 49.47 µM 0.108616422695772 0.438938606056335 no 1456 0.456753367197253 2078 3784940
SGTC_2165 5727197 32.143 µM 0.10792041992969 0.439226180434135 no 1457 0.457029409480983 2114 1361712
SGTC_3029 9088683 49.47 µM 0.107737920846014 0.43930159070821 no 1458 0.457101794043553 2145 25236615
SGTC_3157 9099274 49.47 µM 0.10768567971427 0.439323177622595 no 1459 0.457122514691734 2216 17217662
SGTC_553 k007-0256 45.7 µM 0.107301171316868 0.439482068507692 no 1460 0.457275027666208 2109 6287000
SGTC_2079 5212404 121 µM 0.107178522710416 0.439532752796649 no 1461 0.457323676833025 2213 758462
SGTC_852 0418-0143 439 µM 0.105648944190563 0.440164931029659 no 1462 0.457930445086579 2229 5369229
SGTC_1942 st076330 65.2 µM 0.105242717151728 0.440332851282366 no 1463 0.45809160776191 2166 24208414
SGTC_1619 st003326 88.7 µM 0.105064414138587 0.440406558991538 no 1464 0.458162348191269 2233 2849032
SGTC_3328 9140624 29.0385 µM 0.104500223911613 0.440639800102211 no 1465 0.458386195298766 2212 4904392
SGTC_2499 avocadenofuran 51.48 µM 0.104383957063416 0.440687868383145 no 1466 0.45843232676841 2211 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2369 9071472 200 µM 0.103916135422721 0.44088128902338 no 1467 0.458617951108663 2161 17296037
SGTC_1471 k673-0312 37 µM 0.103459422276512 0.441070130467774 no 1468 0.45879917647696 2226 24099884
SGTC_781 4335-2806 94.4 µM 0.101777023645273 0.44176588279256 no 1469 0.459466831702638 2209 845254
SGTC_3008 9078912 71.4286 µM 0.101067384231324 0.442059406653734 no 1470 0.459748484525436 2150 16648731
SGTC_171 k064-0041 9.68 µM 0.0998644365919356 0.442557047208904 no 1471 0.460225975327732 2113 53325
SGTC_1452 4194-0072 190 µM 0.0997440268389716 0.442606863837337 no 1472 0.46027377322069 2222 1343545
SGTC_2708 st078559 56 µM 0.0997202986742486 0.442616680899718 no 1473 0.460283192428064 2226 17250902
SGTC_1614 st002383 48.6 µM 0.0989936531979088 0.442917333234318 no 1474 0.460571654683314 2260 1947235
SGTC_2056 5235370 200 µM 0.0983878136287216 0.443168026800572 no 1475 0.460812175522431 2125 5511916
SGTC_3275 9138069 49.47 µM 0.0978460327215716 0.443392232466827 no 1476 0.46102727695123 2131 17617007
SGTC_909 3448-9333 149 µM 0.0976919568189494 0.44345599714534 no 1477 0.46108845126751 2166 3344074
SGTC_642 0335-0876 158 µM 0.096052493104339 0.444134583454519 no 1478 0.461739440893071 2158 6812350
SGTC_1485 3909-9022 254 µM 0.0957820711261892 0.444246528927568 no 1479 0.461846828525621 2218 714516
SGTC_885 0865-0106 16.8 µM 0.0952242047109442 0.444477480634085 no 1480 0.46206837238127 2214 2793380
SGTC_64 000l-0018 272.079 µM 0.0944674910934129 0.444790783419122 no 1481 0.462368902640507 2092 6811119
SGTC_2912 7964298 10.93 µM 0.0936455954649997 0.445131112640608 no 1482 0.462695344394112 2141 2975850
SGTC_1717 st033143 58.0435 µM 0.0931461347904724 0.445337948287315 no 1483 0.462893733231082 2236 674616
SGTC_1522 st012842 45.6 µM 0.0930656397592232 0.445371284121031 no 1484 0.462925707215088 2199 3491067 YOR116C RPO31
SGTC_2522 biochanin a 4.94 µM 0.0925916102442886 0.445567604302706 no 1485 0.463114004585043 2212 5280373 A possible chelator.
SGTC_1251 0490-5699 265 µM 0.0925228293865263 0.445596091129481 no 1486 0.463141326893365 2244 3883818
SGTC_2110 5483698 200 µM 0.0923223104992985 0.445679141228209 no 1487 0.463220981426058 2139 2848765 YHR062C RPP1
SGTC_2602 kawain 100 µM 0.0917112648670398 0.445932236311805 no 1488 0.463463723522373 2275 5369129
SGTC_1093 fluphenazine 7.97 µM 0.0911989572147385 0.446144451111318 no 1489 0.46366725176207 2234 6602611 An atypical antipsychotic.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0903379922946373 0.446501126019243 no 1490 0.464009315038433 2226 5106787 A p450 inhibitor.
SGTC_247 mechlorethamine 29.705 µM 0.0902633285903139 0.446532059253448 no 1491 0.464038980351411 2168 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_556 4058-0063 51.5 µM 0.0900577137800199 0.446617247319886 no 1492 0.464120676067901 2162 6615692
SGTC_541 4513-1321 94 µM 0.0899986202179934 0.446641730770403 no 1493 0.464144155643414 2064 747515
SGTC_2144 5628481 200 µM 0.0899493323462118 0.44666215171512 no 1494 0.464163739231067 2180 2818399
SGTC_2616 abietic acid 100 µM 0.0894733876263996 0.446859352339809 no 1495 0.464352851169393 2273 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2955 9076254 12.21 µM 0.088926269422652 0.447086058872597 no 1496 0.464570253136592 2237 16459619
SGTC_514 4466-0038 2.65 nM 0.0883357106016214 0.447330785071936 no 1497 0.464804928462997 2137 5722064
SGTC_947 3447-0010 211 µM 0.0876313880911188 0.447622680892597 no 1498 0.465084827024329 2251 748350
SGTC_2950 9072895 21.46 µM 0.0863850709064887 0.448139267630936 no 1499 0.465580157127708 2154 17332245
SGTC_94 0334-0113 514.748 µM 0.0861695958607258 0.448228588951354 no 1500 0.465665799886897 2247 6795178
SGTC_325 2810-4341 181 µM 0.0844700203538773 0.448933209173708 no 1501 0.46634136896172 2264 774970
SGTC_1352 1496-0991 99 µM 0.0842067705543659 0.44904236332129 no 1502 0.466446017593115 2226 3000039
SGTC_2335 9018011 154.17 µM 0.0830617403729361 0.449517184491836 no 1503 0.466901223720313 2218 6458208
SGTC_544 k015-0020 52.4 µM 0.0828827908122445 0.449591397853513 no 1504 0.466972368948072 2183 3008304
SGTC_596 1155-0152 116 µM 0.0828554181449336 0.449602749909847 no 1505 0.466983251630901 2241 280313
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0815192875138611 0.450156923083076 no 1506 0.467514493353696 2273 16725076
SGTC_24 0417-1663 219 µM 0.0806029641679074 0.450537033358403 no 1507 0.467878854406426 2170 4329390
SGTC_2640 pentamidine 10.38 µM 0.0802850737023603 0.450668911655384 no 1508 0.46800526467511 2275 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1199 1638-0010 4.46 µM 0.0789402243729153 0.451226888568425 no 1509 0.468540084314816 2198 3111136
SGTC_2090 5301565 104.445 µM 0.0781405677941073 0.45155871120954 no 1510 0.46885811869872 2213 2056344
SGTC_2131 toluylene red 5.2905 µM 0.0761717482801845 0.452375829315699 no 1511 0.469641229488924 2196 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3216 9129716 49.47 µM 0.0749969570830366 0.452863498607125 no 1512 0.470108566486043 2219 8056934
SGTC_2966 9084041 48.03 µM 0.0744754406771386 0.453080008877527 no 1513 0.470316041193158 2245 17741380
SGTC_718 1130-0073 349 µM 0.0741098333067122 0.453231801015383 no 1514 0.470461495466185 2221 6740020
SGTC_2549 cedrol 20.94 µM 0.0741087704176764 0.453232242313503 no 1515 0.470461918334728 2284 6708665 A sedative which affects the nervous system.
SGTC_2628 lathosterol 100 µM 0.0732361033319295 0.453594582119145 no 1516 0.47080911860433 2227 6710616
SGTC_3067 9117431 49.47 µM 0.0730561910404282 0.453669288254122 no 1517 0.470880701470693 2198 17150885
SGTC_670 4204-0025 119 µM 0.0721262608976146 0.4540554551918 no 1518 0.471250713736523 2234 719039
SGTC_2695 st077686 51.995 µM 0.0718752062148758 0.454159716740389 no 1519 0.47135061078958 2206 2876092
SGTC_2575 plumbagin 510 nM 0.0711614602895329 0.454456148501317 no 1520 0.471634626927961 2247 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_580 1123-0028 41 µM 0.0707813448314956 0.454614027778907 no 1521 0.471785889624028 2265 1677248 YPR107C YTH1
SGTC_79 0052-0007 94.094 µM 0.0699956986995262 0.454940365129264 no 1522 0.472098541591374 2273 2801472
SGTC_2924 9010168 62.78 µM 0.0693278261964839 0.455217806244356 no 1523 0.472364338458423 2205 2993929
SGTC_458 nppb 133 µM 0.0679006457525326 0.455810744738256 no 1524 0.472932362352561 2279 4549 A chloride channel blocker.
SGTC_1241 0364-0022 50.8 µM 0.0648740234677421 0.45706851380883 no 1525 0.47413715164176 2242 4563895
SGTC_3318 9139014 38.6185 µM 0.0632345462920418 0.457750009411545 no 1526 0.474789867925914 2274 16643984
SGTC_521 r062-0005 13.8 µM 0.0627590992832941 0.457947665893505 no 1527 0.474979167837305 2277 2832033
SGTC_2407 paclitaxel 400 µM 0.0626987529892476 0.457972754263143 no 1528 0.475003195206063 2190 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_805 3852-0218 479 µM 0.0624360750846231 0.458081961930592 no 1529 0.475107783612426 2281 6615355
SGTC_251 melphalan 456.522 µM 0.0621369413590037 0.458206329865753 no 1530 0.475226889436373 2230 460612 A DNA alkylator.
SGTC_1159 4092-0538 61.2 µM 0.0618752432372844 0.458315136918158 no 1531 0.475331091373383 2307 717301
SGTC_2185 6113692 200 µM 0.0604125711130502 0.458923334004509 no 1532 0.475913523322613 2241 874150
SGTC_2717 st081029 62.2815 µM 0.0600756355422196 0.459063449644012 no 1533 0.476047697463309 2289 5292846
SGTC_1223 0764-0573 147 µM 0.0600238175697139 0.459084998750593 no 1534 0.476068332605016 2292 1609797
SGTC_3178 9107506 49.47 µM 0.0594311250366781 0.459331485370329 no 1535 0.47630436133558 2270 8897194
SGTC_2118 5526350 200 µM 0.0592941802198187 0.459388439664495 no 1536 0.476358898236398 2248 743594
SGTC_2989 9073649 71.4286 µM 0.0589568750548908 0.459528725835965 no 1537 0.476493228524335 2316 21367202
SGTC_2936 9038235 15.59 µM 0.0588690344437476 0.459565259822143 no 1538 0.476528211097697 2302 4749415
SGTC_1915 st067105 30.6 µM 0.0582178510351477 0.459836105605781 no 1539 0.476787550883973 2294 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_269 exalamide 29 µM 0.0582139293135758 0.459837736818416 no 1540 0.476789112775581 2192 3316 A derivative of salicylamide.
SGTC_639 0833-0042 114 µM 0.0579281352538482 0.459956612674872 no 1541 0.476902936027282 2255 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_153 4077-0274 519.67 µM 0.0577177702594039 0.460044116147587 no 1542 0.476986719336097 2309 3121976
SGTC_2655 perillic acid 100 µM 0.0576228615138527 0.460083595045537 no 1543 0.477024519535982 2241 5702197 An apoptosis inducer.
SGTC_3116 9124943 49.47 µM 0.0575462493196468 0.460115463470557 no 1544 0.477055032746861 2259 41905195 YPL160W CDC60
SGTC_2043 5101342 149 µM 0.0566005173723991 0.460508881253253 no 1545 0.477431711201912 2255 678451
SGTC_822 1487-0950 154 µM 0.0549160616802649 0.461209698381655 no 1546 0.478102667908891 2327 1958375
SGTC_2624 nerol 100 µM 0.0546448415206553 0.461322550740625 no 1547 0.478210706868905 2287 637566 A natural product oil.
SGTC_750 4073-0104 132 µM 0.0539311100902723 0.461619543065154 no 1548 0.478495025229158 2309 22330957
SGTC_1573 oleylamine 1.06 µM 0.0533958273033566 0.461842294794788 no 1549 0.478708264900752 2274 5356789 An amine of the fatty acid oleic acid.
SGTC_1154 4088-0362 150 µM 0.0532053472970294 0.461921563733555 no 1550 0.478784147562617 2301 6618304
SGTC_1021 4476-0760 85.3 µM 0.053188549438328 0.461928554295407 no 1551 0.478790839463215 2278 746768
SGTC_1904 st060225 78 µM 0.0530750219869938 0.461975799951082 no 1552 0.478836066480806 2308 66595
SGTC_1851 st056236 18.9 µM 0.0529867342710311 0.462012542193492 no 1553 0.478871238691797 2309 5393171
SGTC_1575 cyproterone acetate 48 µM 0.0507476142083424 0.462944492739815 no 1554 0.479763317425428 2260 9880 An androgen receptor antagonist and liver toxin.
SGTC_1933 st074711 15.9 µM 0.048610853069938 0.463834029953228 no 1555 0.480614710346335 2316 17250958
SGTC_3288 9119690 36.221 µM 0.0484954998377218 0.463882056879921 no 1556 0.480660675416598 2275 17595618 YKL019W RAM2
SGTC_2445 5742597 35.57 µM 0.0479622375580799 0.464104085649703 no 1557 0.480873169007638 2270 1774255
SGTC_3338 9144300 39.5675 µM 0.0476957647640448 0.464215038299059 no 1558 0.480979354745998 2277 4901274
SGTC_1678 st019265 80.2 µM 0.0474727428707402 0.464307901212753 no 1559 0.481068226936605 2330 5367020
SGTC_2884 9058502 51.95 µM 0.0473202868618994 0.464371382687949 no 1560 0.481128979807512 2272 6471554
SGTC_252 miconazole 1.30953 nM 0.0461556421149508 0.464856361352205 no 1561 0.481593098616357 2333 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_343 4130-2827 29.8 µM 0.0452562140112584 0.465230934885287 no 1562 0.481951543905615 2265 1118244
SGTC_1929 genistein trimethyl ether 50.5 µM 0.0445876363037052 0.465509389032654 no 1563 0.482217998829986 2346 136420
SGTC_554 4483-2211 187 µM 0.0437348932280634 0.465864570212148 no 1564 0.482557862521235 2268 747107
SGTC_3166 9102297 49.47 µM 0.0429099849146779 0.466208183644488 no 1565 0.482886644636093 2278 25237072
SGTC_354 2783-3500 4.88 µM 0.041131291533858 0.466949179174145 no 1566 0.483595614333847 2295 6740761
SGTC_1034 k072-0165 12.7 µM 0.0394625386583473 0.467644478201906 no 1567 0.484260810028853 2328 5835461
SGTC_825 1988-2224 89.6 µM 0.0380831653245462 0.468219279588751 no 1568 0.484810686848951 2319 1180859
SGTC_1244 0416-0015 52.5 µM 0.0364026965800924 0.46891964045939 no 1569 0.485480632023078 2311 96201
SGTC_1168 k815-0004 80.5 µM 0.0331767820879354 0.470264357020006 no 1570 0.486766806568822 2342 642433
SGTC_2492 derrusnin 100 µM 0.032967773212716 0.470351493852029 no 1571 0.486850143457584 2334 1715307 Part of coumarin class of compounds.
SGTC_2697 mebhydrolin 72.4 µM 0.0323830110512507 0.47059529161348 no 1572 0.487083305299957 2332 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_184 1494-0393 24.714 µM 0.0314403124132927 0.470988342635063 no 1573 0.487459196186646 2323 3090647
SGTC_3303 9125618 40.5795 µM 0.030926039195157 0.471202776877994 no 1574 0.487664261788622 2307 22695467
SGTC_1569 carminic acid 40.6 µM 0.0304874757818307 0.471385649334836 no 1575 0.487839140808848 2345 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1153 4055-0057 267 µM 0.0300867599182256 0.471552745371696 no 1576 0.487998930003316 2344 882706
SGTC_1370 2001-0092 44.6 µM 0.0300852878197087 0.471553359236923 no 1577 0.487999517019921 2327 790957
SGTC_1529 apigenin 74 µM 0.0297665336349791 0.471686281352685 no 1578 0.488126624611736 2346 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1410 3909-8106 77.9 µM 0.0287538912345242 0.472108579236417 no 1579 0.488530437561699 2348 1039210
SGTC_2834 9001755 58.44 µM 0.0284376246212141 0.472240476983581 no 1580 0.488656558109078 2255 2989575
SGTC_3005 9076496 71.4286 µM 0.0277369950431299 0.472532682614643 no 1581 0.48893595863411 2362 21368410
SGTC_683 panaxydol 45 µM 0.0275811550375128 0.472597679498317 no 1582 0.488998106024583 2341 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2724 maprotiline 69.64 µM 0.0270774178487775 0.4728077803886 no 1583 0.489198993051002 2343 4011 A tricyclic antidepressant.
SGTC_1769 st044406 64.4 µM 0.0240234915812125 0.474081685056534 no 1584 0.490416935270318 2346 670903
SGTC_2147 5545932 89.7195 µM 0.0237659857576925 0.474189112480449 no 1585 0.490519635907398 2338 797404
SGTC_2363 9053361 176 µM 0.0228526507298481 0.474570156727417 no 1586 0.49088390488198 2362 6469797 YMR079W SEC14
SGTC_881 0833-0569 170 µM 0.0217262012612908 0.475040144525012 no 1587 0.491333181559628 2348 5418700
SGTC_283 0987-0079 11.7 µM 0.0212452955922032 0.475240803110257 no 1588 0.491524990883776 2350 411556
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0199313728885778 0.475789071126058 no 1589 0.492049059083086 2357 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_492 tmb-8 126 µM 0.0196772127199455 0.475895131312069 no 1590 0.492150434437911 2373 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1644 st010134 20.9 µM 0.0176463171905696 0.476742677925191 no 1591 0.492960503322293 2374 3818134
SGTC_741 4582-0002 126 µM 0.0173741294019611 0.476856277194457 no 1592 0.493069073893469 2364 2912688
SGTC_152 4469-0003 551.229 µM 0.0158170403499143 0.477506173887461 no 1593 0.493690176951991 2377 697280
SGTC_2414 st077232 92.9 µM 0.0151937588178275 0.477766335542255 no 1594 0.493938800415208 2358 729801
SGTC_1880 MG-132 525 µM 0.0143008200908862 0.478139070299619 no 1595 0.494294992680454 2376 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2019 4016004 108 µM 0.0134301522815488 0.478502527039443 no 1596 0.49464230548347 2366 45595336
SGTC_690 glyoxal 20.3 µM 0.0133771101553736 0.47852466984035 no 1597 0.494663464329485 2375 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2985 9022375 71.43 µM 0.0124669177193441 0.478904646212673 no 1598 0.495026548248127 2348 4939335
SGTC_598 3937-0236 20.2 µM 0.0123342525936792 0.478960031289375 no 1599 0.495079469906693 2374 1379313
SGTC_2819 7996655 46.38 µM 0.0123301871102172 0.478961728555059 no 1600 0.495081091676609 2379 6456960
SGTC_1133 3473-0247 50 µM 0.0117506706591019 0.479203670061561 no 1601 0.495312268530228 2358 711311
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0111898048896518 0.479437832419033 no 1602 0.495536006877656 2358 91467 include heat shock
SGTC_382 3229-0966 23.2 µM 0.0104832683890054 0.479732822631324 no 1603 0.495817857605123 2380 5722370
SGTC_754 3474-0146 171 µM 0.0101781298395338 0.479860226264622 no 1604 0.49593958377773 2394 24762078
SGTC_1982 st072467 71.9 µM 0.00816481593556128 0.4807008904759 no 1605 0.496742745902033 2379 3163533
SGTC_2283 7944793 200 µM 0.00778108107509799 0.480861129771969 no 1606 0.49689582909573 2384 2970533
SGTC_1229 0139-0193 12.2 µM 0.00757490053681269 0.480947227540128 no 1607 0.496978080805234 2395 3090752
SGTC_1308 1187-1617 41.4 µM 0.00724832578565336 0.481083601865788 no 1608 0.497108361702259 2390 2882570
SGTC_2722 naftopidil 47.16 µM 0.00684716624854892 0.481251125074874 no 1609 0.497268397227134 2384 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_904 1141-0088 396 µM 0.00585058041353325 0.481667311067783 no 1610 0.497665969423529 2385 1378119
SGTC_567 1080-0542 68.4 µM 0.00482250806460705 0.482096667132812 no 1611 0.498076105092658 2401 5950415
SGTC_1020 4335-0961 93.3 µM 0.00384929939955959 0.482503129501071 no 1612 0.498464355511894 2392 669075
SGTC_2440 5628896 157.78 µM 0.00327230194039094 0.482744122153663 no 1613 0.498694542731536 2401 5522048
SGTC_2789 5281112 71.43 µM 0.00303259581172646 0.482844241291744 no 1614 0.498790171165727 2395 765948
SGTC_2998 9066762 71.4286 µM 0.00275373702517601 0.482960714857636 no 1615 0.498901419259986 2399 4945196
SGTC_1207 2099-0101 141 µM 0.00132554467770966 0.483557263937986 no 1616 0.499471184338361 2404 5837381
SGTC_2135 5326629 150.42 µM 0.000556525151946999 0.483878495029915 no 1617 0.499777978598242 2402 5020077
SGTC_326 k292-0812 17.5 µM 0.000402199921242088 0.483942960281235 no 1618 0.499839545450568 2404 3579357
SGTC_2178 5812956 200 µM 0.00031878916012843 0.483977803078075 no 1619 0.499872821527645 2405 5403383
SGTC_1564 D-Arginine 115 µM -0.000294253591225637 0.484233890367612 no 1620 0.499882609802994 2406 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1934 st074720 32.6 µM -0.00110216764004509 0.484571391459242 no 1621 0.499560298817319 2409 17250992
SGTC_3027 9089541 49.47 µM -0.00138554239197904 0.484689772138163 no 1622 0.499447248735406 2409 9943819
SGTC_2240 6690706 185.951 µM -0.0014185525112273 0.484703562305512 no 1623 0.499434079616101 2405 805876
SGTC_2565 isoliquiritigenin 100 µM -0.00232879805957261 0.485083829773683 no 1624 0.499070944831277 2408 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2895 9054447 58.44 µM -0.00266384334647824 0.485223802936851 no 1625 0.498937281517577 2411 2697450
SGTC_2611 pyromycin 23.93 µM -0.00319212001138688 0.485444506810729 no 1626 0.49872653052604 2417 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1284 0929-0043 16 µM -0.00355691151688113 0.485596912322421 no 1627 0.498581000600377 2425 1239883
SGTC_827 3253-0474 693 µM -0.0043224263143017 0.485916742028253 no 1628 0.498275606758886 2418 5402065
SGTC_2068 5226020 147 µM -0.00481968469909833 0.486124499904156 no 1629 0.498077231439443 2421 1810509
SGTC_2017 5132927 60.65 µM -0.0062310455844561 0.486714196239538 no 1630 0.497514188550919 2417 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_404 fumagillin 50 µM -0.00658094348615805 0.486860395504094 no 1631 0.497374602348931 2420 12015870 A methionine aminopeptidase binder.
SGTC_745 0469-0705 296 µM -0.00709470354632083 0.487075065155865 no 1632 0.4971696465327 2417 3486736
SGTC_2353 9059630 146.67 µM -0.00777368510882933 0.487358776742952 no 1633 0.496898779570144 2412 4779114
SGTC_2208 7283366 200 µM -0.00797716136520606 0.487443800291743 no 1634 0.496817606805857 2421 898663
SGTC_1330 1469-0054 61.8 µM -0.00858012627079136 0.487695755462692 no 1635 0.496577066858022 2426 7102664
SGTC_1479 0549-0158 134 µM -0.00996835108784646 0.488275858176254 no 1636 0.496023269145262 2427 5440202
SGTC_185 k048-0037 25.491 µM -0.0120680041872016 0.489153294827729 no 1637 0.49518567974692 2424 6827589
SGTC_2091 4-phenylthiadiazole 200 µM -0.0125868393813252 0.48937012223825 no 1638 0.494978710180441 2433 270010
SGTC_1503 4585-0012 61.3 µM -0.0129437129571504 0.489519265785894 no 1639 0.494836349822487 2444 2922052
SGTC_1885 st057546 99.9 µM -0.013161349516588 0.489610220532815 no 1640 0.494749532793099 2449 702008
SGTC_2897 9048598 12.99 µM -0.0140008441085605 0.489961067425284 no 1641 0.494414653801027 2438 6467404
SGTC_2953 9074162 66.49 µM -0.0144615582753455 0.49015361532398 no 1642 0.494230874053472 2432 16451992
SGTC_1396 3511-0007 98.6 µM -0.0145396938691906 0.490186271037459 no 1643 0.494199705738516 2444 X1396
SGTC_1181 1222-0449 220 µM -0.0151488837840003 0.490440875952598 no 1644 0.493956700903347 2434 658318
SGTC_2149 5554786 194.827 µM -0.0154274340707297 0.490557294600897 no 1645 0.493845588402911 2438 745063 YPR165W RHO1
SGTC_2439 5492030 7.2 µM -0.0159486563306686 0.490775138895544 no 1646 0.49363767639497 2438 5722370
SGTC_2686 alizarin 95.37 µM -0.016245564200843 0.490899232461536 no 1647 0.4935192426377 2454 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1950 st077106 7.18 µM -0.0181211479673883 0.491683158384884 no 1648 0.492771103541252 2471 13831864
SGTC_1731 st035964 63 µM -0.0185060651438021 0.491844043862639 no 1649 0.492617569554977 2476 6739575
SGTC_1128 3448-9350 235 µM -0.0185728146695361 0.491871943582993 no 1650 0.49259094492295 2466 619386
SGTC_2896 9052656 71.43 µM -0.0194615789616969 0.492243429737015 no 1651 0.492236443390366 2444 6469436
SGTC_2277 7947813 106.88 µM -0.0198812749741025 0.492418856849467 no 1652 0.492069041299842 2555 1246798
SGTC_439 amiodarone 34.4 µM -0.0206918052653524 0.492757651390435 no 1653 0.491745753036434 2488 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_456 gingerol 170 µM -0.0220554168948617 0.493327640734504 no 1654 0.491201874989937 2474 442793 A herb.
SGTC_380 3970-0968 6 µM -0.0225616435738972 0.49353924689825 no 1655 0.490999970013687 2449 2891601
SGTC_985 1493-0307 8.71 µM -0.0237747053403347 0.494046322177701 no 1656 0.490516158279834 2457 3278274
SGTC_2466 5983409 37.09 µM -0.0243658006537344 0.494293411089176 no 1657 0.490280413673406 2479 2879657
SGTC_1124 fisetin 1.16336 µM -0.0254416805227376 0.494743154576986 no 1658 0.489851332803531 2495 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3192 9110362 49.47 µM -0.0261806188679647 0.495052052363527 no 1659 0.489556637243432 2455 16649480
SGTC_2040 5100729 123 µM -0.0267125707822925 0.495274425630521 no 1660 0.489344493338238 2464 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2272 7805186 180 µM -0.0279647242886081 0.495797872348776 no 1661 0.488845143038116 2449 2956062 YPR165W RHO1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0285316118006883 0.496034854837829 no 1662 0.48861907785771 2490 616764
SGTC_2842 9000675 19.48 µM -0.028592278015544 0.496060215915846 no 1663 0.488594885409543 2483 2989072
SGTC_3118 9124250 49.47 µM -0.0291292743753712 0.496284704092944 no 1664 0.48838074406225 2519 1504786
SGTC_1089 terbinafine 2.25 µM -0.0305071695775226 0.496860730309275 no 1665 0.487831287773936 2465 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1090 efavirenz 20.7 µM -0.0309069565453113 0.497027861695783 no 1666 0.487671871027029 2479 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3064 1327-0027 10 µM -0.0309087160977571 0.497028597279814 no 1667 0.487671169402373 2458 16000455 YPR107C YTH1
SGTC_1768 st044301 37.178 µM -0.0312092342715718 0.497154229583329 no 1668 0.48755133780957 2473 3931349
SGTC_776 4476-4378 112 µM -0.0316758364395416 0.497349294231675 no 1669 0.487365282471288 2527 2892008
SGTC_2184 6075246 200 µM -0.031744311839125 0.497377920663484 no 1670 0.487337978470163 2482 2267320
SGTC_2210 7115885 190.385 µM -0.0318365255991118 0.49741647103905 no 1671 0.487301209087312 2463 2927039
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0325484597259207 0.497714099075863 no 1672 0.487017335604454 2478 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3185 9108267 49.47 µM -0.032644551723101 0.497754270972929 no 1673 0.486979020804747 2482 4910486
SGTC_3199 9111318 49.47 µM -0.034013408421254 0.498326532876402 no 1674 0.486433229257162 2496 8548020
SGTC_451 chloral hydrate 100 µM -0.0366208347665044 0.499416597644385 no 1675 0.485393665464996 2516 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1127 asiatic acid 681.4 nM -0.0368677315612891 0.499519816060629 no 1676 0.485295234365342 2483 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2514 salinomycin 42.74 µM -0.0375123987200322 0.499789327685044 no 1677 0.485038227178292 2505 23682228 A polyether potassium ionophore.
SGTC_1505 k297-0037 20.6 µM -0.0379809136766146 0.499985196621011 no 1678 0.484851449863324 2481 4089396
SGTC_2893 9048488 25.97 µM -0.0380517325033484 0.499985196621011 no 1679 0.484823217647646 2485 6467338
SGTC_1860 st056228 74.6 µM -0.0388180299695579 0.499664835752566 no 1680 0.484517734915499 2570 688679
SGTC_1940 st075990 51.1 µM -0.0395466583195381 0.499360223157504 no 1681 0.484227277315412 2670 1084979
SGTC_1187 1391-0724 117 µM -0.0395588933864299 0.49935510813073 no 1682 0.484222400046471 2499 6997986
SGTC_406 estrone 100 µM -0.0395875185860844 0.499343140998972 no 1683 0.484210989182471 2484 5870 A steroid.
SGTC_2681 menadione 3.18 µM -0.039765565384146 0.499268706265755 no 1684 0.484140014673948 2503 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2345 9052315 157.45 µM -0.0399670488240626 0.499184473576542 no 1685 0.484059698260805 2518 6469265
SGTC_1604 st002052 72.4 µM -0.0402264806016916 0.499076014909116 no 1686 0.483956283122415 2572 6254834 YHR062C RPP1
SGTC_2461 5755302 26.15 µM -0.0405600541322483 0.49893656046519 no 1687 0.483823315058742 2474 2788904
SGTC_763 3453-1109 128 µM -0.0412288265586238 0.498656972482369 no 1688 0.483556736467133 2471 1560353
SGTC_955 1216-0110 33 µM -0.0414046053778238 0.498583486234916 no 1689 0.4834866706934 2479 3619719
SGTC_1334 1486-0610 236 µM -0.0417648914703838 0.498432864867744 no 1690 0.48334306156352 2589 3742339
SGTC_3295 9122362 53.5725 µM -0.0419730309582907 0.498345850079507 no 1691 0.483260098670987 2512 4730473
SGTC_2060 5238662 140 µM -0.0426628198263526 0.498057477550849 no 1692 0.482985159024558 2523 790130
SGTC_189 3970-0742 2.116 µM -0.0427288759843592 0.498029862222289 no 1693 0.482958830438848 2490 2891807
SGTC_3224 9130643 49.47 µM -0.0430026924907106 0.497915391047028 no 1694 0.482849693771781 2540 17644395
SGTC_3087 9117406 49.47 µM -0.0433961058353173 0.497750921762128 no 1695 0.482692890936029 2576 42546093
SGTC_1835 st008666 49.2 µM -0.0434402518946942 0.497732466207086 no 1696 0.482675295798883 2487 690455
SGTC_1692 fluoroquinolonic acid 71 µM -0.0440949861895745 0.497458750752225 no 1697 0.482414344670193 2579 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0451762424602378 0.497006728001405 no 1698 0.481983415341188 2478 88881 An O-methylated flavonoid and antioxidant.
SGTC_312 4092-0653 6.84 µM -0.0455341759401935 0.496857093547471 no 1699 0.481840767338949 2572 1148278
SGTC_2218 6965428 192.983 µM -0.045595809732302 0.496831327522274 no 1700 0.48181620452489 2496 675684
SGTC_3248 9135562 49.47 µM -0.0460241275105478 0.496652269518168 no 1701 0.481645509655137 2498 17650701
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0460340770976163 0.496648110106817 no 1702 0.481641544546803 2501 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1691 st019933 84.6 µM -0.0462435259734915 0.496560550374194 no 1703 0.481558075426159 2479 6176082
SGTC_290 2043-6722 48.1 µM -0.0463430479933478 0.496518945427383 no 1704 0.481518414405541 2525 773758 YLR208W SEC13
SGTC_1948 st076329 66.6 µM -0.0473900027732019 0.49608127082018 no 1705 0.481101198350447 2481 24208413
SGTC_3213 9129884 49.47 µM -0.0475059583144329 0.496032796422591 no 1706 0.481054990825466 2523 17190742
SGTC_2710 st078562 53.7235 µM -0.0486698988045687 0.49554622266019 no 1707 0.48059118235506 2472 17250908
SGTC_3039 9090270 49.47 µM -0.0493764539423439 0.495250857487466 no 1708 0.48030964615037 2503 17173750
SGTC_663 1486-0733 13.9 µM -0.0522627537562707 0.494044310297652 no 1709 0.479159665467079 2516 722445 YPR165W RHO1
SGTC_3014 9081533 49.47 µM -0.0526855749662121 0.493867564522319 no 1710 0.47899121628596 2512 21367265
SGTC_2323 6148992 148.28 µM -0.0526870703054351 0.493866939449618 no 1711 0.478990620559318 2538 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2904 7225135 42.03 µM -0.0528353577191072 0.493804953312594 no 1712 0.47893154472371 2540 4446116
SGTC_2756 carbadox 75.1 µM -0.0536647498928504 0.493458259008547 no 1713 0.478601133911466 2529 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3299 9121982 43.1275 µM -0.054012771780987 0.493312783801519 no 1714 0.478462494343327 2531 17594604 YPL160W CDC60
SGTC_450 aminopyrene 156 nM -0.0540311257574701 0.493305111755344 no 1715 0.478455182842717 2490 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1651 st011928 86.1 µM -0.0544732664941614 0.493120295658746 no 1716 0.478279053601882 2572 720198
SGTC_3203 9113543 49.47 µM -0.0548967301126736 0.492943288035125 no 1717 0.478110368472305 2610 17018012
SGTC_1476 4112-3294 3.34 µM -0.05491704997723 0.492934794374505 no 1718 0.478102274229528 2596 704369
SGTC_2239 6685329 187.64 µM -0.0555451123870712 0.492672267207512 no 1719 0.477852095456479 2644 805680
SGTC_1985 st071382 65.5 µM -0.0593790485472633 0.491069772735636 no 1720 0.476325100223319 2515 6123237
SGTC_2198 6589944 200 µM -0.0597742527832048 0.490904594483732 no 1721 0.476167716101035 2529 5290268
SGTC_1826 st055655 41.6 µM -0.0598209222941458 0.490885088752122 no 1722 0.476149130917637 2548 676168
SGTC_3220 9131269 49.47 µM -0.0598876905831405 0.490857182683908 no 1723 0.476122541894947 2500 17722206
SGTC_1625 st003711 30.1 µM -0.0600139027593083 0.490804431932305 no 1724 0.476072280924238 2562 24207034 YER133W GLC7
SGTC_21 0849-0113 22.993 µM -0.0603179961618624 0.490677335859385 no 1725 0.475951184588533 2509 1560156
SGTC_2638 epoxomicin 18 µM -0.061760729574667 0.490074357430688 no 1726 0.475376688507881 2580 9915668 A protesome inhibitor.
SGTC_2167 5876490 200 µM -0.0636034553051257 0.489304238713504 no 1727 0.474642990189894 2736 686534
SGTC_1829 berberine 14.4 µM -0.0636544784604234 0.489282915482805 no 1728 0.474622676059974 2661 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1978 st071761 42 µM -0.0643525306842051 0.488991193611778 no 1729 0.474344763330567 2556 5147680
SGTC_1309 pyrazolanthrone 13.4 µM -0.06560924320933 0.488466017871998 no 1730 0.473844464977457 2547 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_930 2810-3379 265 µM -0.0657759273338965 0.488396362645564 no 1731 0.47377811096325 2542 1015764
SGTC_483 fpl-64176 144 µM -0.0662342796029782 0.488204824753482 no 1732 0.473595652754038 2537 3423
SGTC_2788 5282734 71.43 µM -0.0675959021192568 0.48763584126282 no 1733 0.473053658787509 2588 743706
SGTC_929 2805-0021 398 µM -0.0678729233592341 0.487520084974551 no 1734 0.472943396531899 2621 3098024
SGTC_3163 9099914 49.47 µM -0.0691127018703138 0.487002043282584 no 1735 0.472449955287455 2528 16268368
SGTC_643 k048-0106 28.4 µM -0.0707642519021427 0.486311976998627 no 1736 0.471792691659913 2627 6763920
SGTC_532 1548-0774 215 µM -0.0710089459076031 0.486209740066702 no 1737 0.471695317830566 2694 5932993
SGTC_3205 9113483 49.47 µM -0.0710852667566178 0.486177852223223 no 1738 0.471664946965212 2620 17018033
SGTC_1272 0839-0021 27 µM -0.072343110232504 0.485652321740025 no 1739 0.47116442877342 2611 5027250
SGTC_1146 3579-1023 7 µM -0.0756465613020983 0.484272251754576 no 1740 0.469850145999954 2648 X1146
SGTC_95 0471-0001 561.058 µM -0.0758673577131678 0.484180017024531 no 1741 0.469762313379204 2562 4015405
SGTC_2260 7964312 200 µM -0.0763780354173975 0.483966691535793 no 1742 0.469559171875467 2729 231951
SGTC_3097 9117246 49.47 µM -0.0768542397595897 0.48376777074457 no 1743 0.469369750602226 2531 16423892
SGTC_1802 st050112 57.9 µM -0.0795007048351629 0.482662360372046 no 1744 0.468317185505863 2515 4662563
SGTC_3095 9117207 49.47 µM -0.079864737101013 0.482510316818284 no 1745 0.468172417963561 2538 17015229
SGTC_2360 9040895 200 µM -0.079926356376948 0.482484580851557 no 1746 0.468147913762859 2585 4914414
SGTC_828 2074-0507 139 µM -0.0801989704730336 0.482370721460204 no 1747 0.46803950448479 2630 X828
SGTC_1311 1190-0148 100 µM -0.0804464432314702 0.482267363788301 no 1748 0.467941095106763 2625 1961333
SGTC_3032 9089427 49.47 µM -0.0805286884353328 0.482233014118316 no 1749 0.467908390124842 2624 17173707
SGTC_2459 5811157 9.22 µM -0.0806114659605807 0.482198442257732 no 1750 0.467875473682894 2529 2870684 YBR192W RIM2
SGTC_1175 0741-0056 27.6 µM -0.0814785061305895 0.481836332834552 no 1751 0.467530708830048 2626 765927
SGTC_1141 3253-0389 52.6 µM -0.0819259518503051 0.481649468083701 no 1752 0.467352798605777 2531 5402031
SGTC_2820 7989630 71.43 µM -0.0821786292738059 0.481543945322201 no 1753 0.467252333662428 2552 2984098
SGTC_1296 1068-0102 11.9 µM -0.0825449625254481 0.481390960084837 no 1754 0.467106682688337 2634 767053
SGTC_2487 5918373 44.05 µM -0.0829482421594669 0.481222548757092 no 1755 0.46694634724167 2541 2876279
SGTC_465 cgp-37157 41 µM -0.0840679724793368 0.480754962172312 no 1756 0.466501194366717 2531 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_742 0kpi-0133 140 µM -0.0844660066937695 0.480588753978861 no 1757 0.466342964478389 2650 2728852
SGTC_73 0327-0325 16.231 µM -0.0844745767375142 0.480585175400169 no 1758 0.46633955770137 2715 53298
SGTC_54 0159-0055 9 µM -0.0875497666905131 0.479301176755333 no 1759 0.465117264580799 2555 3319099
SGTC_1718 roemerine 11.9335 µM -0.0878101883731492 0.479192451332558 no 1760 0.465013769948628 2578 235224 An aporphine alkaloid with mutagenic activity.
SGTC_728 3030-5151 22.5 µM -0.0879455350207325 0.479135945045397 no 1761 0.464959982537063 2565 3125388
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0883142631814656 0.478982005724914 no 1762 0.464813451435632 2737 94937 An inhibitor of serotonin biosynthesis.
SGTC_2318 6029776 164 µM -0.0893205031046333 0.47856192936583 no 1763 0.464413600036623 2632 818325
SGTC_1444 4112-3581 28 µM -0.0894992206920369 0.478487322366868 no 1764 0.464342586448575 2551 2877249
SGTC_231 b-estradiol 524 µM -0.0899652368489539 0.478292783974729 no 1765 0.464157419873383 2557 450 A steroid.
SGTC_1279 0874-0590 65.2 µM -0.0901096891812155 0.478232483412778 no 1766 0.464100024846141 2627 3523074
SGTC_1283 0922-0125 16.4 µM -0.0903547013933225 0.478130206009899 no 1767 0.464002676222408 2636 3360884
SGTC_490 phenamil 164 µM -0.0907141814500997 0.477980147989876 no 1768 0.463859850963175 2661 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3003 9075612 71.4286 µM -0.0929116545946722 0.477062923838946 no 1769 0.462986873386699 2651 6501993
SGTC_1448 4255-0083 152 µM -0.0931597486552601 0.476959377049549 no 1770 0.462888325598079 2723 5399660
SGTC_3124 9127567 49.47 µM -0.0949033557817479 0.476231693630799 no 1771 0.462195795512209 2601 17592030
SGTC_2801 7907800 81.82 µM -0.0950002314297643 0.476191265492927 no 1772 0.462157321549404 2644 6620925
SGTC_1974 st069448 26.9 µM -0.0954259285727006 0.476013616504721 no 1773 0.461988261012828 2626 6323587 YNR016C ACC1
SGTC_107 0358-0022 2.6945 µM -0.0968911038019458 0.475402216372207 no 1774 0.461406436852092 2660 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_233 rapamycin 362 pM -0.0978489181498059 0.475002563094103 no 1775 0.461026131329224 2613 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3127 9126946 49.47 µM -0.0978542433824292 0.475000341181583 no 1776 0.461024017015252 2682 27243249
SGTC_587 k089-0003 57 µM -0.0993818112190478 0.474363007574813 no 1777 0.460417561903835 2570 9659696
SGTC_1000 4048-0884 8.67 µM -0.0996688213534039 0.474243268148957 no 1778 0.460303627104902 2698 13040088
SGTC_2636 apigenin dimethyl ether 100 µM -0.0997612449451071 0.47420470990838 no 1779 0.460266938280736 2686 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_419 nsc-638432 893 µM -0.100359792142835 0.47395500759419 no 1780 0.460029344887644 2637 368090
SGTC_2025 5147754 141 µM -0.101398125095101 0.473521859497422 no 1781 0.459617212380988 2661 315777 YLR208W SEC13
SGTC_2935 9038016 29.96 µM -0.102049007067541 0.473250355306611 no 1782 0.459358888039945 2612 6463195
SGTC_1493 4348-0038 111 µM -0.10244061574309 0.473087008479784 no 1783 0.459203473262827 2589 800424
SGTC_1567 st069303 68.4 µM -0.102559741325124 0.473037320012759 no 1784 0.45915619802852 2671 5581319
SGTC_582 0987-0078 156 µM -0.102647999632389 0.473000506864067 no 1785 0.45912117290867 2596 1625765
SGTC_2755 lomerizine 42.69 µM -0.102813062002852 0.472931658830062 no 1786 0.45905566911301 2628 3949 A calcium channel blocker.
SGTC_1722 st034304 3.6505 µM -0.102888576008909 0.472900161970038 no 1787 0.459025702301964 2615 4036148 YLR033W RSC58
SGTC_63 0099-0242 26.702 µM -0.103009031457452 0.47284992040413 no 1788 0.458977901510316 2584 3898502 YLR359W ADE13
SGTC_1407 3909-7909 12.3 µM -0.104651293355925 0.472164981865625 no 1789 0.45832625595891 2592 4411780
SGTC_1390 3413-2614 145 µM -0.108353680094758 0.47062113163324 no 1790 0.456857571332096 2634 3421432
SGTC_3145 9085516 49.47 µM -0.108597553116346 0.470519454793612 no 1791 0.456760850803534 2668 25236195
SGTC_3276 9139060 49.47 µM -0.1089334840247 0.470379399837753 no 1792 0.45662762412837 2584 4870619
SGTC_429 1112-0049 25.5 µM -0.109250503230574 0.470247232832541 no 1793 0.456501902107079 2618 2836170
SGTC_1597 7-benzyloxygramine 47.5 µM -0.111632501030198 0.469254271030511 no 1794 0.45555740049218 2594 260807
SGTC_3348 9149464 3.537 µM -0.111933149454745 0.469128955912098 no 1795 0.455438206146209 2581 1951442
SGTC_712 r015-0009 80.6 µM -0.112613535045276 0.468845371521495 no 1796 0.455168476950069 2698 6813872 YLR060W FRS1
SGTC_210 3551-0445 56.827 µM -0.112994040056023 0.468686784096097 no 1797 0.455017640149763 2740 2865180 YOR207C RET1
SGTC_1031 k035-0009 16 µM -0.113406070417575 0.468515063093388 no 1798 0.45485431363205 2798 5180959
SGTC_3175 9106517 49.47 µM -0.113841345937515 0.468333660619583 no 1799 0.454681781154356 2683 41468073
SGTC_2649 anisomycin 9.56 µM -0.115345382344014 0.467706899451446 no 1800 0.454085684238173 2658 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1799 st045822 46.1415 µM -0.115520505864331 0.467633927253992 no 1801 0.454016283976462 2612 3674992
SGTC_489 paxilline 115 µM -0.117055606125782 0.466994313345538 no 1802 0.453407994495448 2667 105008 A toxic potassium channel blocker.
SGTC_2349 9023730 187.07 µM -0.11713110428873 0.466962858513689 no 1803 0.453378080861427 2696 4126287
SGTC_2142 5622915 118.518 µM -0.117620310583263 0.466759045294903 no 1804 0.4531842555689 2649 5322196
SGTC_884 0851-0618 334 µM -0.118359278668555 0.466451192815544 no 1805 0.452891494918539 2749 9642473
SGTC_749 1000-0129 128 µM -0.119229963454223 0.466088493218396 no 1806 0.452546584279342 2739 708470
SGTC_1216 1165-0504 9.65 µM -0.121092263980304 0.465312812956279 no 1807 0.451808978267925 2627 6304004
SGTC_1474 0330-0125 5.35 µM -0.122740646221425 0.464626343192439 no 1808 0.451156238083466 2659 X1474
SGTC_2418 pentamidine 31.67 µM -0.124007152366402 0.464098977364895 no 1809 0.450654806004318 2596 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2803 7707263 71.43 µM -0.124063806375774 0.464075388430178 no 1810 0.450632377518798 2654 2199229
SGTC_2278 7948257 134.34 µM -0.127744441060738 0.462543163116188 no 1811 0.449175609650038 2623 1247028
SGTC_442 cape 100 µM -0.128086110313797 0.462400956167453 no 1812 0.449040413934143 2665 5281787
SGTC_3342 9147791 14.508 µM -0.128740981744273 0.462128404065665 no 1813 0.448781303241055 2628 1838168
SGTC_3052 9092717 49.47 µM -0.128979143347157 0.462029287568577 no 1814 0.448687076081918 2776 25237534
SGTC_672 1441-0018 53.7 µM -0.129142103015466 0.46196146946611 no 1815 0.44862260376865 2632 251141
SGTC_543 3844-1095 191 µM -0.129262450797845 0.461911385646936 no 1816 0.448574991018311 2734 4230703
SGTC_496 calpeptin 138 µM -0.129727908418811 0.461717686936285 no 1817 0.44839085071042 2709 73364 A calpain inhibitor.
SGTC_854 0422-0053 192 µM -0.130426624462207 0.46142693553393 no 1818 0.448114451613042 2650 3596728
SGTC_2088 5278280 127.392 µM -0.130748635002239 0.461292946663015 no 1819 0.44798707869121 2698 791502
SGTC_2907 7721985 69.9 µM -0.130981935268066 0.461195872959684 no 1820 0.447894798922991 2680 3267881
SGTC_2361 9034121 116 µM -0.130992925925951 0.461191299923449 no 1821 0.447890451739152 2678 6496917
SGTC_705 1124-0212 310 µM -0.132377066285115 0.460615422568208 no 1822 0.447343026739227 2632 9554485
SGTC_2015 5119600 184 µM -0.133274911551947 0.460241914397274 no 1823 0.446987984130471 2768 2828786
SGTC_2057 5236571 38.335 µM -0.134683103738184 0.459656170107516 no 1824 0.446431216361187 2722 54684039 YBR257W POP4
SGTC_310 1273-0058 1.06 µM -0.134898701981637 0.459566498681856 no 1825 0.44634598291967 2689 2734232
SGTC_2961 9083290 32.55 µM -0.135555861918923 0.459293186026097 no 1826 0.446086200180051 2632 17741490
SGTC_336 4111-0029 111 µM -0.135788604043623 0.459196393240476 no 1827 0.445994200134985 2703 3131175
SGTC_470 aa-861 153 µM -0.136309867548121 0.458979618978314 no 1828 0.445788161759729 2665 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1983 st071813 46.9 µM -0.136788171140499 0.458780720887596 no 1829 0.445599116907275 2709 11838595
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.137122947558756 0.458641513370131 no 1830 0.445466807132683 2850 165506
SGTC_1233 0325-0408 14.2 µM -0.137642061789004 0.458425664106389 no 1831 0.445261655693272 2725 12874
SGTC_1336 1486-0901 104 µM -0.138956119369053 0.457879329932254 no 1832 0.444742412114923 2741 5006114
SGTC_1660 st012960 28.1 µM -0.13904956276602 0.457840482810499 no 1833 0.444705492002877 2724 24207266
SGTC_2674 ligustilide 100 µM -0.139580497644625 0.457619765487299 no 1834 0.444495725191649 2741 5319022 A signalling regulator.
SGTC_593 1203-0218 61.7 µM -0.140002603916044 0.45744429911582 no 1835 0.444328966512715 2771 3666956
SGTC_2038 4100038 30.985 µM -0.140215470726115 0.457355815143601 no 1836 0.444244874393181 2745 3596803
SGTC_341 1486-1430 230 µM -0.140580827640752 0.45720394937547 no 1837 0.444100547565384 2641 2054753 YPL210C SRP72
SGTC_81 0411-0046 9.971 µM -0.140784147981996 0.457119439105565 no 1838 0.444020233203738 2634 12925265
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.141817363141698 0.456690012404783 no 1839 0.443612134443251 2655 3256 An antibiotic and ribosome inhibitor.
SGTC_446 go6976 132 µM -0.142741573332256 0.456305933377401 no 1840 0.443247141057162 2749 3501 A protein kinase C inhibitor.
SGTC_2281 7943571 200 µM -0.142921834212595 0.45623102613469 no 1841 0.443175957193803 2733 1244024
SGTC_2592 piperlongumine 83.33 µM -0.143049508942662 0.456177971959166 no 1842 0.443125540372607 2744 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3337 9144342 33.5465 µM -0.143340489970964 0.456057060126282 no 1843 0.443010639804452 2757 17682949
SGTC_108 0509-0257 621.132 µM -0.144356769673901 0.455634795720889 no 1844 0.442609375991395 2760 536624
SGTC_2316 5844804 197.44 µM -0.146091580158842 0.454914097679922 no 1845 0.44192454658233 2774 776813
SGTC_2721 ifenprodil 61.44 µM -0.146844182070132 0.454601487793495 no 1846 0.441627505206595 2796 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_864 0469-0573 172 µM -0.147187660966588 0.454458825552601 no 1847 0.441491949822656 2655 689425
SGTC_166 k072-0058 166.424 µM -0.147447220848423 0.454351022550474 no 1848 0.441389517974198 2660 5846229
SGTC_1501 4491-0275 38.4 µM -0.147557124536048 0.454305377266275 no 1849 0.44134614712942 2665 5104718
SGTC_2978 9011784 42.97 µM -0.148354471621964 0.453974240567993 no 1850 0.441031514388665 2823 2994934
SGTC_2617 dihydrotanshinone i 20.83 µM -0.148402887884383 0.453954134416058 no 1851 0.441012410553515 2676 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2545 solidagenone 89.61 µM -0.150686322056983 0.453006012027539 no 1852 0.440111581720812 2643 6708572 An anti ulcer agent
SGTC_2173 5763948 167 µM -0.15089135789878 0.452920890532619 no 1853 0.440030708914353 2664 2867177
SGTC_771 0250-0039 27.3 µM -0.152686678759582 0.452175648332151 no 1854 0.439322683194838 2662 3005115
SGTC_680 0417-1641 114 µM -0.152964281000934 0.452060429917102 no 1855 0.4392132216879 2666 2835990
SGTC_1338 1486-1223 76 µM -0.153137199076339 0.451988662556189 no 1856 0.439145040606276 2745 3444526
SGTC_983 1491-0821 12.2 µM -0.153303632294883 0.451919588131045 no 1857 0.439079418189488 2815 46495113
SGTC_972 1319-0219 195 µM -0.153732760583209 0.451741494648471 no 1858 0.438910226309467 2739 23903702
SGTC_1804 st050076 49.1 µM -0.153923887782202 0.451662177649534 no 1859 0.438834874415651 2770 3895976
SGTC_1055 3448-0672 86 µM -0.154943985495904 0.451238874016748 no 1860 0.438432738470481 2824 748378
SGTC_2810 7959871 45.46 µM -0.154988759158457 0.451220295833859 no 1861 0.438415089556414 2785 2974535
SGTC_2625 euphol 100 µM -0.156227818340392 0.450706208705121 no 1862 0.437926725042879 2792 6708538 A triterpene alcohol.
SGTC_858 0438-0351 2.77 µM -0.15823333209261 0.44987429425733 no 1863 0.437136469694605 2698 2799119
SGTC_304 1310-0298 97 µM -0.15833984360309 0.449830117957409 no 1864 0.437094506739687 2683 1550234
SGTC_1109 tnp00067 928.257 nM -0.158581926000661 0.449729715116746 no 1865 0.436999134772293 2706 676295
SGTC_2859 9028643 45.46 µM -0.160729678700637 0.44883908373595 no 1866 0.436153156555742 2795 17151580
SGTC_2903 5923464 63.88 µM -0.161058068539214 0.448702929446395 no 1867 0.436023832737492 2737 2876576
SGTC_2483 5729050 27.16 µM -0.162491445645559 0.448108705380973 no 1868 0.435459432071899 2766 2865180
SGTC_1224 0823-0416 294 µM -0.163312288571607 0.447768467213404 no 1869 0.435136279457777 2817 3598164
SGTC_1173 0443-0020 122 µM -0.163491835460812 0.447694050408983 no 1870 0.435065600511175 2711 5331295
SGTC_1488 4013-0813 75.9 µM -0.16452384544206 0.447266348984633 no 1871 0.434659388281793 2702 2910057
SGTC_1087 pterostilbene 9.05 µM -0.165242471855876 0.446968560975248 no 1872 0.434376568509092 2822 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2403 6032726 181.2 µM -0.165926777091255 0.44668502293447 no 1873 0.434107287256376 2775 2881040
SGTC_1797 st048695 56.8 µM -0.165970917371581 0.446666734590708 no 1874 0.434089918643695 2824 592262 YIL048W NEO1
SGTC_386 1509-0011 3.07 µM -0.166019361340948 0.446646663259138 no 1875 0.434070856733127 2698 3107280
SGTC_1765 st044815 90.4 µM -0.166027655255924 0.446643226933504 no 1876 0.434067593228442 2781 645695
SGTC_2970 9090938 41.86 µM -0.166464980287674 0.446462040593944 no 1877 0.433895520153941 2908 17217104
SGTC_2957 9076800 11.52 µM -0.166698114017576 0.446365456479664 no 1878 0.433803794784708 2755 16459615
SGTC_2773 thioridazine 9.09 µM -0.167242284857901 0.446140026337757 no 1879 0.433589707206917 2675 5452 An antipsychotic.
SGTC_2976 9009005 19.48 µM -0.167619237658564 0.445983878735422 no 1880 0.433441417933896 2904 2993148
SGTC_1684 st024538 14.6195 µM -0.168262607319655 0.445717390912992 no 1881 0.433188344719212 2710 6732859
SGTC_762 1165-0429 115 µM -0.169531856320352 0.445191731891061 no 1882 0.432689158639918 2850 5967793
SGTC_370 0180-0345 38.7 µM -0.170533841160821 0.444776828234431 no 1883 0.432295161364692 2654 3989527
SGTC_911 3456-4043 236 µM -0.170682206617952 0.444715397934366 no 1884 0.432236827286628 2803 914281
SGTC_706 4262-0057 46.9 µM -0.173094041820758 0.443716971627785 no 1885 0.431288754100726 2715 883298
SGTC_1922 5578187 25 µM -0.173391008233581 0.443594061146618 no 1886 0.431172046225314 2952 1350412
SGTC_1104 tacrolimus 29.8 µM -0.173666648996683 0.443479981925938 no 1887 0.431063724712903 2702 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_259 usnic acid 108.925 µM -0.173721758948163 0.44345717417627 no 1888 0.431042068184845 2887 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1708 st033234 31.827 µM -0.175059488729101 0.442903600296064 no 1889 0.430516444981545 2830 674664
SGTC_313 3474-0040 5.03 µM -0.176214289909207 0.442425814763621 no 1890 0.430062797363843 2712 1043375 YIL048W NEO1
SGTC_628 1636-0253 16 µM -0.176818687651081 0.442175785575098 no 1891 0.429825404858748 2813 4456143
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.177166079101972 0.442032085987806 no 1892 0.429688969552591 2832 688662
SGTC_2537 larixol 68.93 µM -0.1779925521114 0.441690243473597 no 1893 0.429364412449625 2684 6708759
SGTC_89 0302-0250 142.109 µM -0.179958883901781 0.440877112083347 no 1894 0.428592423521832 2688 4203518 YLR208W SEC13
SGTC_1464 k208-0027 110 µM -0.180894895614156 0.440490133252888 no 1895 0.428225037733675 2915 X1464
SGTC_1813 st051246 8.6015 µM -0.1823069345605 0.43990645634557 no 1896 0.427670928444402 2775 5291959
SGTC_1795 st049545 62.3 µM -0.182360599128935 0.439884276260748 no 1897 0.427649872316205 2706 5291882
SGTC_1767 st044992 70.3 µM -0.183699063399726 0.439331137254875 no 1898 0.42712477185224 2782 9600693
SGTC_1790 st045711 43.5 µM -0.185237824339341 0.438695369267522 no 1899 0.426521251444871 2852 585119
SGTC_1546 5-methoxyflavanone 78.7 µM -0.187255256006005 0.437862069317811 no 1900 0.425730251462487 2820 147795
SGTC_11 0438-0307 1.3 µM -0.187935987371853 0.437580955270785 no 1901 0.425463415753268 2842 4011476
SGTC_3214 9129694 49.47 µM -0.189399454409437 0.436976710441421 no 1902 0.424889876024065 2850 17158655
SGTC_2413 inermin 26.06 µM -0.189989261591138 0.436733228882053 no 1903 0.42465877264221 3048 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_611 3453-1652 23.7 µM -0.190618776689062 0.436473381720672 no 1904 0.424412139130078 2821 1560575
SGTC_3149 9097855 49.47 µM -0.190999007145766 0.436316445928825 no 1905 0.42426318551068 2894 25236625 YMR079W SEC14
SGTC_650 1328-0195 38 µM -0.191856171134971 0.435962698060209 no 1906 0.423927434975534 2750 2780821
SGTC_1920 st075728 45.7 µM -0.192030853918033 0.435890613505596 no 1907 0.423859018616006 2927 3400306
SGTC_2794 7785382 27.27 µM -0.194636003681974 0.434815827050361 no 1908 0.422838957593243 2749 2205081
SGTC_1418 3966-3099 2.4 µM -0.195186019747521 0.434588972477304 no 1909 0.422623661600598 2823 740335
SGTC_3112 9123419 49.47 µM -0.196142610994006 0.434194476979302 no 1910 0.422249272606328 2735 17015854
SGTC_1385 3091-4834 14.1 µM -0.197614006707767 0.433587805631042 no 1911 0.421673537574716 2864 4072814
SGTC_2777 climbazole 1.536 µM -0.1976488745947 0.433573431140129 no 1912 0.421659896320029 2799 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1966 st070145 16.1 µM -0.197917121376139 0.433462847770494 no 1913 0.421554954112952 2726 3748532
SGTC_1029 k015-0030 64.7 µM -0.199682473302576 0.432735220757752 no 1914 0.420864460996682 2864 2208316
SGTC_1013 4112-3890 241 µM -0.199904160006132 0.43264386397377 no 1915 0.420777768449419 2753 705171
SGTC_2309 7664088 163.95 µM -0.200713176073209 0.432310500151521 no 1916 0.420461428179861 2886 704922
SGTC_2308 7584454 197.62 µM -0.201354621163556 0.43204621999749 no 1917 0.420210647763551 2900 893577
SGTC_907 3448-6986 75.5 µM -0.201365159657759 0.432041878312955 no 1918 0.420206527886867 2914 590582
SGTC_126 0417-1624 672.48 µM -0.202276757080044 0.431666346436693 no 1919 0.419850184778716 2806 41912 YDL195W SEC31
SGTC_2443 5493264 126.67 µM -0.202686663361316 0.431497505955476 no 1920 0.419689973955997 2935 5340055
SGTC_3036 9090181 49.47 µM -0.204041837147444 0.430939398841681 no 1921 0.419160402627653 2747 25236586
SGTC_277 nystatin 15.5 µM -0.205450570731873 0.430359380139011 no 1922 0.418610056558901 2724 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_752 1896-0090 130 µM -0.205997002235826 0.43013443794373 no 1923 0.418396626479811 2759 772567
SGTC_17 0960-0276 49.807 µM -0.207230314080021 0.429626820294158 no 1924 0.417914996958538 2763 6821114
SGTC_1676 st018489 23.4 µM -0.207356941636654 0.429574708349233 no 1925 0.417865553671564 2828 3696235
SGTC_696 1560-0013 611 µM -0.208529832043813 0.429092078802289 no 1926 0.417407645987488 2981 1650269
SGTC_3151 9099821 49.47 µM -0.208791598064615 0.428984379841741 no 1927 0.417305465281673 2906 17174189
SGTC_1648 st011736 69.8 µM -0.209024776486123 0.428888447191184 no 1928 0.417214448485088 2935 2855514
SGTC_905 2-aminofluorene 215 µM -0.209469625680685 0.428705442073891 no 1929 0.417040822304719 2778 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1145 3546-0597 10.2 µM -0.210543126936841 0.428263880950863 no 1930 0.41662189773913 2818 875334
SGTC_149 3970-0822 46.1 µM -0.210593228201424 0.428243275087078 no 1931 0.416602348463434 2778 3114250 YBL034C STU1
SGTC_3135 9127742 49.47 µM -0.212675892761799 0.427386881606827 no 1932 0.415789885693062 2847 3643468
SGTC_3265 9137266 49.47 µM -0.213946775833226 0.426864461166475 no 1933 0.415294281401252 2747 17224265
SGTC_3230 9131665 49.47 µM -0.215535346879893 0.426211629555038 no 1934 0.414674978382048 2776 15943720
SGTC_1201 1889-3372 45.9 µM -0.21576919541381 0.426115545298694 no 1935 0.414583830603593 2821 5392199
SGTC_989 1501-0895 10.3 µM -0.215812363722019 0.42609780867824 no 1936 0.41456700527751 2821 2830112
SGTC_3119 9125183 49.47 µM -0.216015397627248 0.426014389872018 no 1937 0.414487872667797 2851 22695334
SGTC_1636 st007707 68.9 µM -0.217272723497033 0.425497877003453 no 1938 0.41399790642397 2952 403051
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.218397811498166 0.425035796149089 no 1939 0.413559585278966 2892 5379071
SGTC_787 4152-0075 138 µM -0.218894339516999 0.424831901621334 no 1940 0.413366177980799 2822 9566539
SGTC_469 w7 172 µM -0.21904163166043 0.424771421362675 no 1941 0.413308808873308 2807 45115570 A P450 inhibitor.
SGTC_51 1013-0126 23.419 µM -0.219513518436574 0.424577669841672 no 1942 0.413125025231453 3043 1627850
SGTC_739 1486-1183 203 µM -0.220580620225887 0.424139596846813 no 1943 0.412709496105788 2882 4346692
SGTC_1793 st048256 72.231 µM -0.220675964322906 0.424100460171791 no 1944 0.412672373894914 2770 672022
SGTC_1719 st032227 49.2 µM -0.222731545272297 0.423256871615652 no 1945 0.411872224215563 2825 3125804
SGTC_1379 2144-0755 36.5 µM -0.222778030828806 0.423237798489912 no 1946 0.411854133601015 2939 5392327
SGTC_1035 k081-0041 55.2 µM -0.224031476331988 0.422723575016772 no 1947 0.411366405537533 2818 731709
SGTC_2121 5257820 149.641 µM -0.224608423683966 0.422486927729188 no 1948 0.411141955585487 2944 791256
SGTC_1930 st074634 34.3 µM -0.225063700260094 0.422300206054365 no 1949 0.410964859768482 2783 684253 YOR116C RPO31
SGTC_3207 9114163 49.47 µM -0.226111019100476 0.421870737616412 no 1950 0.410557537255397 3080 849233
SGTC_2221 6807166 181.081 µM -0.226779978814127 0.42159646947028 no 1951 0.410297416359629 2870 674925
SGTC_2680 butyl paraben 22.24 µM -0.226900837697513 0.421546922344496 no 1952 0.410250425326793 2783 7184 An antifungal and steroid mimetic.
SGTC_3340 9146634 11.102 µM -0.227999747367422 0.421096472076744 no 1953 0.409823218460912 2882 4907387
SGTC_2698 st077697 67.5 µM -0.228136399008145 0.421040464881696 no 1954 0.40977010189464 2856 3154499
SGTC_2994 9053520 71.4286 µM -0.228359709967694 0.42094894347466 no 1955 0.409683304368965 2955 4647384
SGTC_2074 5212007 75.395 µM -0.228496378874203 0.42089293341525 no 1956 0.409630185456048 2854 758611
SGTC_209 4077-0173 175.592 µM -0.228864568981838 0.420742048616271 no 1957 0.409487089778044 2890 15993494
SGTC_61 0978-8327 98.565 µM -0.228880888372682 0.420735361177356 no 1958 0.409480747588093 2798 6150059 YHR072W ERG7
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.229081101601636 0.42065331869435 no 1959 0.409402940832474 2812 688664
SGTC_694 1315-0438 43.2 µM -0.229492200227602 0.420484871342178 no 1960 0.409243191098571 2851 6793154
SGTC_3081 9117243 49.47 µM -0.229901607835396 0.420317131353948 no 1961 0.409084113459011 2997 45595589
SGTC_1463 k081-0032 34.1 µM -0.229991745671584 0.420280202572048 no 1962 0.409049091903581 2884 977755
SGTC_186 3455-3465 67.277 µM -0.230168547899167 0.420207770090446 no 1963 0.408980400450776 2798 755278
SGTC_479 n-linoleoylglycine 10 µM -0.230321433287071 0.420145138057894 no 1964 0.408921003456122 2829 6433346 An anti-infammatory.
SGTC_2567 aureobasidin a 60 nM -0.231185588757623 0.419791160511876 no 1965 0.408585312641651 3075 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_811 0416-0114 265 µM -0.231708347216605 0.419577058350864 no 1966 0.408382273835029 2899 6612453
SGTC_2940 9060638 45.86 µM -0.232401918445685 0.419293034471641 no 1967 0.408112929504676 2931 4027022
SGTC_818 4072-2707 53.5 µM -0.234190750349396 0.418560685568533 no 1968 0.407418447765087 2780 882871
SGTC_2378 9074213 121.43 µM -0.234606076813951 0.41839069092538 no 1969 0.407257246282953 2822 657714
SGTC_2823 7987624 58.44 µM -0.235370520825381 0.418077841058298 no 1970 0.40696058219532 3033 2239440
SGTC_918 glabranin 770.725 nM -0.235447937621831 0.418046161004213 no 1971 0.406930541394668 2866 124049 Also referred to as licorice root.
SGTC_2143 5623677 140.463 µM -0.237043335346798 0.417393420246576 no 1972 0.40631158569177 2815 5375313
SGTC_367 0335-0881 7.1 µM -0.237365211592379 0.417261755384841 no 1973 0.406186737857462 2980 23828853
SGTC_1024 4507-0395 26 µM -0.237423264396143 0.417238009623028 no 1974 0.406164221625703 3001 4201836
SGTC_2263 7948595 193.29 µM -0.237600411574298 0.41716555168681 no 1975 0.406095515632617 2820 2971371
SGTC_2372 9071633 200 µM -0.238596283673872 0.41675826577909 no 1976 0.405709323556778 2940 21321366
SGTC_1108 betulinic acid 729.144 nM -0.239722062811655 0.416297958849397 no 1977 0.405272864966224 2866 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3219 9131112 49.47 µM -0.240503296659441 0.415978596515021 no 1978 0.404970053944774 2903 17612988 YMR079W SEC14
SGTC_1613 st002381 52.1 µM -0.240694485797806 0.415900448320282 no 1979 0.404895956522585 2834 551167
SGTC_1333 1482-0047 286 µM -0.241504397477837 0.415569435386544 no 1980 0.40458210432229 2955 3811116
SGTC_1998 st075797 76.8 µM -0.242535684952051 0.415148032341327 no 1981 0.404182554747131 2842 24208315
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.242860495149975 0.415015329102921 no 1982 0.404056734876423 2819 364106
SGTC_141 0443-0274 32.331 µM -0.243362141698599 0.414810397323093 no 1983 0.403862434423845 2963 1627241
SGTC_1226 3909-7979 35.4 µM -0.24485456644256 0.414200851829111 no 1984 0.403284520835452 2949 6615510
SGTC_205 1486-1330 71.903 µM -0.245231422984609 0.414046966326142 no 1985 0.403138623525672 2828 4118834
SGTC_3056 9094900 49.47 µM -0.24546926578015 0.413949852451254 no 1986 0.403046551330326 2880 25236784
SGTC_1118 chelidonine 707.474 nM -0.245634043080647 0.413882575120757 no 1987 0.402982766937969 2965 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1723 st034307 2.5525 µM -0.246892087165348 0.413369008649402 no 1988 0.402495870164563 2917 867466
SGTC_2188 6126565 140.678 µM -0.247107869854151 0.413280935380844 no 1989 0.402412371653411 2948 874518
SGTC_2177 5811945 192 µM -0.247198882578857 0.413243789185686 no 1990 0.402377155023931 2998 5343475
SGTC_1992 st073643 23.3 µM -0.248034171390405 0.412902908320039 no 1991 0.402053983888351 2807 3161292
SGTC_352 k048-0007 5.11 µM -0.249480736398923 0.412312721471052 no 1992 0.401494470019761 2926 6811911
SGTC_3250 9135583 49.47 µM -0.249605604339853 0.41226178563436 no 1993 0.401446182058732 2984 7699353
SGTC_2146 5545642 200 µM -0.250261061492381 0.411994437352986 no 1994 0.401192733456601 2859 825326
SGTC_1162 k048-0130 20.1 µM -0.251502786339921 0.411488073899209 no 1995 0.400712704112851 2857 6797406
SGTC_933 2914-0560 114 µM -0.251749411652721 0.411387519985722 no 1996 0.400617380853041 3054 463887
SGTC_377 3970-0964 33.1 µM -0.252339390334593 0.411146997886283 no 1997 0.400389371952192 2840 16481235
SGTC_3236 9132701 49.47 µM -0.252648440918482 0.411021017682188 no 1998 0.40026994679927 2899 24282524
SGTC_5 0352-0601 109.883 µM -0.252662783610233 0.411015171304616 no 1999 0.400264404637896 2908 762456
SGTC_2634 4'-methoxyflavone 100 µM -0.254116799111898 0.41042258732281 no 2000 0.399702662727295 2929 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2920 7982904 15.77 µM -0.254128836381204 0.410417682385445 no 2001 0.399698013133426 2954 6456808
SGTC_168 3970-0862 530.542 µM -0.254200226532303 0.410388592668842 no 2002 0.399670437802055 2946 3135186
SGTC_2157 5649910 96.377 µM -0.255014451499423 0.410056851097068 no 2003 0.399355968742149 2857 2858091
SGTC_2315 7733312 200 µM -0.256462603089076 0.409466986505346 no 2004 0.398796826698273 2877 726316
SGTC_426 0988-0037 14.6 µM -0.258200288227121 0.40875945894321 no 2005 0.39812616774669 3043 5383008
SGTC_2102 5377816 72.7585 µM -0.258312661286406 0.408713714580858 no 2006 0.39808280774112 3050 1379702
SGTC_2234 tolnaftate 200 µM -0.261020424265702 0.407611826975107 no 2007 0.39703837840096 2902 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_919 tnp00227 403.569 nM -0.26140393423739 0.407455821626478 no 2008 0.396890511702465 2894 1269246 A methoxyflavone. YNL221C POP1
SGTC_190 3970-0790 3.722 µM -0.26369113822222 0.406525731442336 no 2009 0.396008962301064 2941 2832352
SGTC_457 grayanotoxin iii 135 µM -0.264305593756008 0.406275953059108 no 2010 0.395772225152394 2906 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1560 lithocholic acid 53.1 µM -0.26561373879054 0.405744314543363 no 2011 0.395268351777275 2895 9903 A bile acid which acts as a detergent.
SGTC_3104 9120930 49.47 µM -0.266434507680757 0.405410837482626 no 2012 0.394952296035657 2963 17014836
SGTC_36 0335-0881 14.2 µM -0.26671232757019 0.405297975254481 no 2013 0.394845330809302 2861 23828853
SGTC_2714 st079313 56.9 µM -0.267259652422703 0.405075651720289 no 2014 0.394634624934611 2881 2939799
SGTC_2932 9016711 44.54 µM -0.267998023340476 0.404775773759455 no 2015 0.39435042012319 3009 7117328
SGTC_274 sirtinol 40.1 µM -0.269503804408683 0.404164397471777 no 2016 0.393771007496935 2905 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_732 3970-1727 52.7 µM -0.270096246761558 0.403923918457886 no 2017 0.393543104747617 2995 1275699
SGTC_1061 3448-9325 110 µM -0.270150325734478 0.403901969001612 no 2018 0.393522303278569 2885 723482
SGTC_991 3996-0057 64.7 µM -0.27132216796106 0.403426418650189 no 2019 0.393071629072062 2973 715343
SGTC_2053 5265679 138 µM -0.272333186101011 0.403016247702119 no 2020 0.392682920672966 2867 764595
SGTC_1097 itavastatin 7.23 µM -0.273207559776363 0.402661599554838 no 2021 0.392346834555338 2914 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_165 k038-0023 64.381 µM -0.274213429911551 0.402253715184168 no 2022 0.39196030398417 2903 46368543
SGTC_301 4119-0100 24.5 µM -0.274214558244685 0.402253257700228 no 2023 0.39195987045394 2909 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1184 1269-1718 139 µM -0.274868616780449 0.401988091483158 no 2024 0.391708589472658 3042 5403821
SGTC_862 0452-0056 10.2 µM -0.275137671963252 0.401879025121041 no 2025 0.391605234996238 2955 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.276222591190856 0.401439311189782 no 2026 0.391188553358063 2883 1241132 A phosphatase inhibitor.
SGTC_1406 3909-7906 11.9 µM -0.279935255999195 0.399935528583578 no 2027 0.389763588875394 2942 X1406
SGTC_480 am 92016 50 µM -0.28006905517523 0.399881361938772 no 2028 0.389712262700596 2962 2129 K+ channel blocker.
SGTC_320 4092-0846 5.34 µM -0.280291348552028 0.399791373967026 no 2029 0.389626993866576 2995 1359356
SGTC_1980 st071811 45.7 µM -0.280888918109955 0.399549494493335 no 2030 0.38939780034167 3048 4974850
SGTC_2746 daunorubicin 9.88 µM -0.282816462785962 0.398769541379746 no 2031 0.388658766925432 2924 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1319 1306-0155 43.7 µM -0.28309320572361 0.398657594447113 no 2032 0.388552694852421 2895 3122360
SGTC_631 k072-0230 41.5 µM -0.283324921631518 0.398563868078968 no 2033 0.388463887462684 3013 5773147
SGTC_2765 myclobutanil 7.74 µM -0.283618552549617 0.398445106219765 no 2034 0.388351358914769 3014 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_614 0462-0418 107 µM -0.284333216157459 0.398156092947891 no 2035 0.38807751665421 2940 5188303
SGTC_1328 1441-0025 69.2 µM -0.285654185334924 0.397622034069085 no 2036 0.387571498945167 2885 4562601
SGTC_2023 5144124 124 µM -0.285777868650312 0.397572039549547 no 2037 0.387524129896542 2913 2830192
SGTC_3140 9094243 49.47 µM -0.286364384418052 0.397334984621835 no 2038 0.387299525040904 2925 19291112
SGTC_2285 7945142 200 µM -0.286678190272567 0.397208167749513 no 2039 0.38717936930075 3020 2970608
SGTC_2338 7999974 200 µM -0.289914562574595 0.395900904208863 no 2040 0.38594080026605 2977 315925
SGTC_1182 1222-0449 220 µM -0.290400352772943 0.395704780255951 no 2041 0.385754986925811 2983 658318
SGTC_15 0266-0086 27.098 µM -0.290687516568146 0.395588858469051 no 2042 0.385645159932167 2999 1712902 YIL048W NEO1
SGTC_1623 st003709 20.3 µM -0.290970580771269 0.395474600637823 no 2043 0.385536909816647 2904 16192618
SGTC_3030 9087619 49.47 µM -0.293279445756769 0.394542972047308 no 2044 0.38465428158217 2967 25236973
SGTC_666 0272-0154 136 µM -0.295901093780414 0.393485866354704 no 2045 0.383652807868887 2970 6870312
SGTC_2618 avocadyne 43.43 µM -0.297120450025812 0.392994462170393 no 2046 0.383187276062326 2894 3015189
SGTC_2828 7998861 71.43 µM -0.297432260248898 0.392868829064551 no 2047 0.383068258675426 3046 2988188
SGTC_418 lividomycin a 100 µM -0.297547523388297 0.39282239060788 no 2048 0.38302426574136 3051 72394 An antibiotic.
SGTC_2016 5121758 140 µM -0.298389274917447 0.392483302963224 no 2049 0.382703036912673 2863 2795203
SGTC_620 0109-0052 432 µM -0.299794035489482 0.391917596971469 no 2050 0.382167132592121 3079 493037
SGTC_980 1473-0395 201 µM -0.299860661163888 0.391890772054188 no 2051 0.382141721055919 2926 768876
SGTC_2228 7354201 200 µM -0.300198476640251 0.391754768250846 no 2052 0.382012883492854 2960 753451
SGTC_2085 5307070 144.047 µM -0.300527226146634 0.391622427087651 no 2053 0.381887516093213 2906 2840351
SGTC_263 alizarin 107.927 µM -0.300781491055297 0.391520078990565 no 2054 0.381790561610916 2978 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_230 MPP+ 141.667 µM -0.300971464763579 0.391443614638602 no 2055 0.381718127029946 2979 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3277 9138724 49.47 µM -0.301529788253417 0.391218913916194 no 2056 0.381505269299515 2984 15943418
SGTC_661 1304-0007 33.6 µM -0.301633791612054 0.391177061133602 no 2057 0.381465622553715 2954 3117130
SGTC_1816 st051957 91.6 µM -0.305033261987775 0.389809750799037 no 2058 0.380170409679876 2971 674121
SGTC_719 2810-4230 27.3 µM -0.305640681854557 0.38956558177468 no 2059 0.379939121057153 2929 721079
SGTC_1038 k292-0204 154 µM -0.307487141237521 0.388823614935756 no 2060 0.379236304538963 2901 4454212
SGTC_2979 9012552 45.46 µM -0.307551185406252 0.388797887184443 no 2061 0.379211934598357 3064 17100905
SGTC_2404 5161160 200 µM -0.308538891238524 0.388401168935113 no 2062 0.378836155874421 2878 2831543
SGTC_3204 9114183 49.47 µM -0.309023626622951 0.388206514476659 no 2063 0.378651777197793 2891 17027248
SGTC_46 0329-0187a 2.197 µM -0.309776850584498 0.387904099196699 no 2064 0.378365328400877 3043 46494817
SGTC_1506 4226-2149 212 µM -0.311751882198295 0.38711145808793 no 2065 0.37761454758077 3055 991114
SGTC_1946 st076057 65.1 µM -0.311967490881325 0.387024956099101 no 2066 0.377532614867133 2929 953009
SGTC_14 0354-0009 295 µM -0.312543123246036 0.386794040464621 no 2067 0.377313897799234 2938 1713507
SGTC_524 r073-0010 27.8 µM -0.312731053660241 0.3867186606192 no 2068 0.377242500342551 2934 2772106
SGTC_2694 st077685 81.9 µM -0.315006322204539 0.385806378689256 no 2069 0.376378426819265 2913 2838096
SGTC_164 4100-3994 89.624 µM -0.316767754091979 0.385100555706524 no 2070 0.375709916809665 3072 4615967
SGTC_2350 9023895 38.85 µM -0.320763686879929 0.383500760411982 no 2071 0.374194740031182 3119 2997209
SGTC_1815 st051655 58.2 µM -0.321012803766754 0.383401090419538 no 2072 0.374100343998763 3070 5984156
SGTC_2083 5306046 65.942 µM -0.323148032249387 0.382547116992115 no 2073 0.373291567721684 2983 539837
SGTC_2164 5685496 200 µM -0.323366332355803 0.382459841103795 no 2074 0.373208911953436 3091 759046
SGTC_2800 7887935 81.82 µM -0.323413686071835 0.382440909983156 no 2075 0.373190983012589 3146 2961002
SGTC_2654 protoveratrine a 100 µM -0.324347183356085 0.382067772828279 no 2076 0.372837600802234 2987 5702278 A heart drug and vasodilator.
SGTC_1394 3474-0001 65.7 µM -0.325310227280313 0.38168294006919 no 2077 0.37247314561129 3009 5017666 YIL048W NEO1
SGTC_1071 trifluoperazine 6.31 µM -0.326065374438527 0.381381264703278 no 2078 0.372187446895136 3128 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1627 st003713 25.6 µM -0.326085013075929 0.381373420182229 no 2079 0.372180017846013 3056 16195070 YER133W GLC7
SGTC_365 0121-0052 13.6 µM -0.326388208130974 0.381252317151668 no 2080 0.372065329014885 3105 3101739
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.32692460968 0.381038094608786 no 2081 0.371862453555427 2982 390807
SGTC_927 2425-1185 123 µM -0.327008531804477 0.381004581948682 no 2082 0.371830716111615 2950 730375
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.327168017617939 0.380940896866334 no 2083 0.371770404595215 2980 4620898
SGTC_428 3448-4153 16.5 µM -0.32843435413841 0.380435344260261 no 2084 0.371291635713291 2914 3834874
SGTC_2656 pseudo-anisatin 100 µM -0.328585872755996 0.380374867968699 no 2085 0.371234363789103 3008 6708809 A neurotoxin.
SGTC_1989 st071868 50.2 µM -0.329123998653247 0.380160107056569 no 2086 0.371030982759215 3114 16414057
SGTC_2540 epiandrosterone 100 µM -0.330106069133669 0.379768267368085 no 2087 0.370659908770288 3001 441302 A steroid.
SGTC_2216 7189485 200 µM -0.330734948824275 0.379517413285702 no 2088 0.370422350589967 3096 731273
SGTC_2737 bleomycin 30.5 nM -0.331002849815529 0.379410565542907 no 2089 0.370321166470073 3004 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_421 streptovitacin 30 mM -0.331247930109121 0.379312827512212 no 2090 0.370228609408293 3157 91467 include heat shock
SGTC_2190 6049624 200 µM -0.331942035301965 0.379036060209613 no 2091 0.369966514323659 3077 2265554
SGTC_2297 7971671 152.32 µM -0.331990564253879 0.379016712106847 no 2092 0.369948191981079 3168 909016
SGTC_2145 5634607 200 µM -0.332381656462299 0.378860797857731 no 2093 0.369800543988172 2984 308662
SGTC_1044 1222-0021 1.78 µM -0.3326368208967 0.378759083695202 no 2094 0.369704222787628 3077 4306703
SGTC_2375 9072683 200 µM -0.332764818655035 0.378708064132142 no 2095 0.369655908404715 3158 16798029
SGTC_1142 3253-1408 9.78 µM -0.33366633512471 0.378348782004508 no 2096 0.369315677867654 3110 256655
SGTC_868 0527-0199 213 µM -0.334541929366665 0.377999931334982 no 2097 0.368985328282619 3016 2849450
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.335127577266842 0.377766655387058 no 2098 0.368764425423333 3193 688751
SGTC_1047 2043-3044 82 µM -0.335139935477004 0.377761733330418 no 2099 0.368759764447734 3014 669592
SGTC_2822 7994718 71.43 µM -0.335854179509204 0.377477296304068 no 2100 0.368490415701084 2974 1018011
SGTC_1262 0737-0114 49.6 µM -0.340271171679566 0.375719776487145 no 2101 0.366826162457499 3170 765919
SGTC_901 1112-0062 60.1 µM -0.342916344836276 0.374668493431698 no 2102 0.365830697552481 3015 1908457
SGTC_2987 9018338 71.43 µM -0.343327606084985 0.37450512744035 no 2103 0.365676007451083 3128 5055682
SGTC_3046 9092212 49.47 µM -0.343622664429853 0.374387934797754 no 2104 0.365565038882496 3053 25236637
SGTC_3016 9080866 49.47 µM -0.344552582629478 0.374018661536381 no 2105 0.365215379351105 3007 17066299
SGTC_1326 1431-2094 10.8 µM -0.345084492270207 0.373807490590071 no 2106 0.365015425784787 2949 616278
SGTC_1353 1498-1206 8.11 µM -0.345335594050175 0.373707815008718 no 2107 0.364921045251911 3050 6756808
SGTC_2982 9019404 25.97 µM -0.347381069282386 0.372896172863151 no 2108 0.364152526706007 3027 22333232
SGTC_2677 mitomycin C 100 µM -0.349386020695483 0.372101157677884 no 2109 0.363399763373454 3039 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3053 9095903 49.47 µM -0.349417864515038 0.372088535165507 no 2110 0.363387811788249 3090 17174018
SGTC_2357 9067248 200 µM -0.349511306805369 0.37205149654342 no 2111 0.36335274190454 3111 9150235
SGTC_579 4491-1009 110 µM -0.349771819250366 0.371948240964581 no 2112 0.363254974866432 3145 1271041
SGTC_2701 st077767 14.721 µM -0.349890570579756 0.371901176259687 no 2113 0.363210411944274 3054 5721188
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.349891027187398 0.37190099529611 no 2114 0.363210240600116 3037 4330530
SGTC_569 4130-2812 160 µM -0.350468270530474 0.371672243802103 no 2115 0.362993649233004 3051 743552
SGTC_1072 oxiconazole 14.9 nM -0.351108963009246 0.371418401568799 no 2116 0.362753301992176 3062 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_808 0711-0032 135 µM -0.351663892877003 0.371198583647494 no 2117 0.362545171138515 3133 4252555
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.351672846637736 0.371195037242495 no 2118 0.362541813292225 3158 5282362
SGTC_1280 0880-0253 10.1 µM -0.351905879130453 0.371102741594576 no 2119 0.362454424985406 3029 6836607
SGTC_2026 5148700 152 µM -0.35279647035945 0.370750079327732 no 2120 0.362120515048345 3002 79838
SGTC_40 0327-0103 19.753 µM -0.353807336938011 0.370349921172363 no 2121 0.361741637313943 3042 409036
SGTC_2196 6573537 42.6665 µM -0.353822167193567 0.37034405156151 no 2122 0.361736079869246 3143 2903087
SGTC_1254 0550-0035 264 µM -0.354410528574204 0.370111210601627 no 2123 0.361515622660305 3163 15121435
SGTC_1556 plumbagin 1.48 µM -0.355091488389501 0.369841783716587 no 2124 0.361260526491424 3070 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2069 5228469 200 µM -0.355213485664397 0.369793521318384 no 2125 0.361214831279098 3128 2835210
SGTC_604 1000-0114 314 µM -0.355615114210913 0.369634650649382 no 2126 0.361064411570155 3171 1572745
SGTC_1295 1013-0063 9.78 µM -0.356536064701639 0.369270437840161 no 2127 0.360719574238963 3161 6826038
SGTC_1814 st052110 31.539 µM -0.357118559204717 0.369040136423759 no 2128 0.360501525559577 3167 674163
SGTC_2838 9002687 71.43 µM -0.357185332118099 0.369013739353775 no 2129 0.360476532948594 2985 6457060
SGTC_1270 0831-1170 17.3 µM -0.357551409056542 0.368869030596106 no 2130 0.360339523634252 3040 6764716
SGTC_1759 st043059 70 µM -0.358389450755283 0.36853782605787 no 2131 0.360025942575891 3008 669426
SGTC_2914 7968218 45.32 µM -0.363000178935397 0.366717361136522 no 2132 0.358302375330977 3131 2977111
SGTC_2223 6903751 107.57 µM -0.363297172374021 0.366600200707045 no 2133 0.358191452690059 3129 5598863
SGTC_561 1550-0330 72.9 µM -0.36340920842093 0.366556007028164 no 2134 0.358149611997894 3052 6812934
SGTC_3048 9093155 49.47 µM -0.363968741926067 0.366335320235154 no 2135 0.357940675570578 3165 25236002
SGTC_1779 st039427 55 µM -0.364741240731968 0.366030709990076 no 2136 0.357652285311706 3256 1124498
SGTC_484 loperamide 105 µM -0.365843934769338 0.365596044091827 no 2137 0.357240766935808 3055 3955 An opioid-receptor agonist.
SGTC_2543 pimpinellin 60.67 µM -0.365861283045728 0.365589207031521 no 2138 0.357234293994845 3041 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_794 k038-0031 316 µM -0.366807878187918 0.365216212967184 no 2139 0.356881165355626 3131 6624242
SGTC_948 3448-0295 75.3 µM -0.37000463105407 0.363957516138499 no 2140 0.355689519909521 3060 678569
SGTC_2411 st077133 39.94 µM -0.370439315612277 0.363786475396213 no 2141 0.355527592212694 3325 1403142 YNL221C POP1
SGTC_1635 st007035 42.4 µM -0.370560939833278 0.363738623258215 no 2142 0.355482289703139 3136 3716403
SGTC_155 k072-0202 43.6 µM -0.372202763091243 0.363092868474619 no 2143 0.354870944502503 3141 5857737
SGTC_1879 gemcitabine 100 µM -0.37470423719257 0.362109747904625 no 2144 0.353940220331467 3075 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3193 9111931 49.47 µM -0.37586968892866 0.361652016156736 no 2145 0.353506887839575 3038 17087244
SGTC_2973 9094665 17.96 µM -0.376337038904736 0.361468519773568 no 2146 0.353333173368721 3257 25237061 YIL048W NEO1
SGTC_438 sphingosine 6.67 µM -0.37716085850099 0.361145139741683 no 2147 0.353027033181042 3033 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1896 st058441 89 µM -0.377795730466682 0.360895996400752 no 2148 0.352791172836201 3110 688759
SGTC_1667 st014849 34.6 µM -0.378460713813201 0.360635099704281 no 2149 0.352544186510804 3088 5348460
SGTC_1902 st060212 70.5 µM -0.379081543775834 0.360391584491267 no 2150 0.352313655612777 3163 688944
SGTC_1973 st070275 50.2 µM -0.38216404522095 0.359183340007007 no 2151 0.351169844581039 3138 17118334
SGTC_2139 5578692 56.4705 µM -0.382478124643809 0.359060309448348 no 2152 0.351053375871386 3153 650991 YMR113W FOL3
SGTC_2241 6772625 37.8075 µM -0.383249009030228 0.358758402155913 no 2153 0.350767571488804 3126 2285411
SGTC_1421 4029-0249 71.4 µM -0.383490765883136 0.358663739251943 no 2154 0.35067795783358 3234 2894095
SGTC_2249 haloperidol 116.36 µM -0.384232148070428 0.358373495990319 no 2155 0.350403196483543 3072 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3035 9091303 49.47 µM -0.386735720860399 0.357393979208542 no 2156 0.349475934241131 3126 25237002
SGTC_2645 abamectin 100 µM -0.387830756006897 0.35696584408322 no 2157 0.349070641748717 3184 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2872 9044037 25.97 µM -0.389669492838361 0.356247342909566 no 2158 0.348390478985089 3072 6465195
SGTC_831 k061-1017 217 µM -0.390184802374097 0.356046072966184 no 2159 0.348199949372801 3164 1240153
SGTC_3183 9108214 49.47 µM -0.390706618848817 0.355842302408129 no 2160 0.348007052930642 3164 4974831
SGTC_387 norethindrone acetate 66.7 µM -0.391010863868468 0.355723513014456 no 2161 0.347894602832839 3113 541197
SGTC_1297 1068-0111 14.1 µM -0.391040533577356 0.355711929525937 no 2162 0.347883637513107 3075 767057
SGTC_2870 9038528 12.99 µM -0.391208904911024 0.35564619741711 no 2163 0.347821413309318 3200 6463316
SGTC_314 1671-0008 2.74 µM -0.392427306622939 0.355170661850658 no 2164 0.34737125653608 3120 3913060
SGTC_3266 9136860 49.47 µM -0.392595924743973 0.355104868858268 no 2165 0.347308974981936 3181 4871271 YPR165W RHO1
SGTC_2871 9038510 12.99 µM -0.392942679920468 0.354969582264198 no 2166 0.347180908875412 3286 4945164
SGTC_1449 4112-4002 201 µM -0.39304935908323 0.354927965046706 no 2167 0.347141512871725 3137 2059539
SGTC_1438 4092-1045 4 µM -0.393382436280152 0.354798037540011 no 2168 0.347018520002797 3097 1351342
SGTC_1414 3917-0015 5.4 µM -0.393619797778643 0.35470545733398 no 2169 0.346930881170623 3201 6618702
SGTC_3302 9125395 16.351 µM -0.393771615857097 0.354646246884329 no 2170 0.346874831052164 3117 17599668
SGTC_413 propylparaben 100 µM -0.394109390198217 0.354514524378692 no 2171 0.346750139270518 3083 7175 A pharmaceutical preservative.
SGTC_1861 st057647 17.4 µM -0.394668605671301 0.354296484302743 no 2172 0.346543737424899 3265 688668
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.394965910798905 0.354180583427239 no 2173 0.346434023081805 3198 17037758
SGTC_583 1488-1091 88.9 µM -0.395733649180452 0.353881352225817 no 2174 0.346150764627238 3195 4303273
SGTC_3070 9117005 49.47 µM -0.397643396248761 0.353137407196167 no 2175 0.345446533552108 3193 8779016
SGTC_2534 helenine 20.12 µM -0.399297600473059 0.352493462522429 no 2176 0.344836967482467 3069 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_76 0433-0009 400.328 µM -0.399744114673892 0.352319716880701 no 2177 0.344672498136426 3183 2841569
SGTC_319 1348-1596 45.5 µM -0.399813177492541 0.352292846211333 no 2178 0.344647062111094 3275 5380505
SGTC_823 0417-1665 178 µM -0.400787091921527 0.351913998270254 no 2179 0.344288441592116 3163 3429856
SGTC_2839 9003951 25.97 µM -0.406083651155192 0.349856244291665 no 2180 0.342340568905409 3231 2990634
SGTC_340 k038-0059 454 µM -0.406188928408323 0.349815387694748 no 2181 0.342301894210819 3182 23733424
SGTC_296 1222-0039 74.9 µM -0.406460189115418 0.349710123306322 no 2182 0.342202251388221 3150 5984176
SGTC_1480 1070-0044 41.2 µM -0.406922013060615 0.349530936260379 no 2183 0.342032633806977 3188 3124987
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.407470640662632 0.349318113084133 no 2184 0.34183117661283 3142 2374 Ca(2+)-ATPase inhibitor.
SGTC_197 4544-0043 41.561 µM -0.409528464241449 0.348520266343865 no 2185 0.341075941154657 3154 896523
SGTC_3243 9134147 49.47 µM -0.409612160194532 0.348487830410591 no 2186 0.341045237608059 3208 24282180
SGTC_114 0364-0001 490.298 µM -0.409643321955845 0.348475754114336 no 2187 0.341033806301649 3182 4003655
SGTC_1033 k072-0102 21.3 µM -0.410005357227601 0.348335463766641 no 2188 0.340901008841635 3274 5965931
SGTC_3172 9105863 49.47 µM -0.411585176481319 0.347723519491137 no 2189 0.340321749246569 3160 2348785
SGTC_2113 5491891 107.031 µM -0.411791806792264 0.347643510360644 no 2190 0.340246013594308 3166 789979
SGTC_1454 4239-0054 42.6 µM -0.412115935167002 0.347518018585935 no 2191 0.340127224675933 3307 1340767
SGTC_636 0kpi-0074 126 µM -0.412812624140134 0.347248340254874 no 2192 0.339871950763861 3181 616434
SGTC_3290 9121031 71.43 µM -0.412933742153329 0.347201465091107 no 2193 0.339827579381529 3155 17014854
SGTC_1105 epirubicin 18.1 µM -0.41302419658502 0.347166458889109 no 2194 0.339794442998675 3108 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_566 0958-0068 16.5 µM -0.4130329505184 0.347163071153483 no 2195 0.339791236215546 3271 6815365
SGTC_2826 7992541 19.48 µM -0.414459097288026 0.346611321559529 no 2196 0.33926895820671 3143 2985066
SGTC_1694 st024011 44.9 µM -0.414514657651345 0.346589832865445 no 2197 0.339248617343312 3236 2787533
SGTC_3316 9136639 10.545 µM -0.414557892100695 0.346573111720616 no 2198 0.339232789368673 3231 4903665
SGTC_1046 2001-0062 216 µM -0.416568499994686 0.345795829497479 no 2199 0.338497026900897 3107 739778
SGTC_1088 bifonazole 369 nM -0.416617939126772 0.345776724959565 no 2200 0.338478942879194 3208 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2996 9066192 71.4286 µM -0.416941737489338 0.345651610747979 no 2201 0.338360511971786 3164 6472854
SGTC_792 4534-1957 155 µM -0.417294689205402 0.34551525101534 no 2202 0.338231436288245 3131 1717904
SGTC_2289 7946404 165.07 µM -0.417651670402852 0.345377354917636 no 2203 0.338100906345513 3111 1246120 YPR165W RHO1
SGTC_2916 7875993 68.79 µM -0.418712151514482 0.344967829204559 no 2204 0.337713256940489 3289 1299250
SGTC_2601 securinine 100 µM -0.41894982097655 0.344876073335183 no 2205 0.337626402583273 3123 442872 A GABA receptor antagonist.
SGTC_3324 9138759 60.749 µM -0.419261649508362 0.344755701078444 no 2206 0.337512460518667 3250 45595710
SGTC_160 3453-0671 289.699 µM -0.420208334728429 0.344390357335134 no 2207 0.337166633278259 3134 5322268
SGTC_1165 k072-0275 30.3 µM -0.421386618628016 0.343935838047236 no 2208 0.336736394437752 3288 6153523 YGL055W OLE1
SGTC_813 k007-0158 173 µM -0.421556899549359 0.343870171348326 no 2209 0.336674235675371 3189 6523916
SGTC_3356 9151811 4.48 µM -0.421841797339529 0.343760314625456 no 2210 0.336570247543216 3117 1859254 YPR165W RHO1
SGTC_3147 9097027 49.47 µM -0.422345496021729 0.343566120457978 no 2211 0.336386427331198 3146 25236841
SGTC_1530 rhein 70.4 µM -0.422682449281214 0.34343623575786 no 2212 0.336263481156045 3174 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_774 k060-0086 136 µM -0.423079840996822 0.343283077724938 no 2213 0.33611850493831 3321 5911235
SGTC_1383 3049-0032 20.7 µM -0.423856465841209 0.342983834439142 no 2214 0.335835247484263 3281 712864
SGTC_995 3931-2021 34.6 µM -0.423864208895162 0.342980851438832 no 2215 0.335832423838563 3222 730143
SGTC_2693 st077581 40.7 µM -0.424585201790372 0.342703132876994 no 2216 0.335569541268217 3268 25238761
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.425139415620876 0.342489713549396 no 2217 0.335367523015451 3173 688761
SGTC_2869 9037858 32.47 µM -0.426708524901619 0.341885746281941 no 2218 0.334795820276678 3111 27187042
SGTC_3189 9110682 49.47 µM -0.428317796030749 0.341266740332398 no 2219 0.334209882109018 3247 17122418
SGTC_255 tunicamycin 200.472 nM -0.42877665587355 0.3410903180844 no 2220 0.334042884431164 3209 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3308 9128332 17.569 µM -0.429215972417378 0.340921442382939 no 2221 0.333883030135018 3289 17332805 YDL196W YDL196W
SGTC_2584 androsterone 48.74 µM -0.429351412113939 0.340869385042537 no 2222 0.333833753712609 3268 2754130 A steroid.
SGTC_3044 9093193 49.47 µM -0.430213262086356 0.340538197070642 no 2223 0.333520257831206 3238 25236277
SGTC_2306 7482397 179.52 µM -0.430394045912905 0.340468741833078 no 2224 0.333454512882825 3298 891448
SGTC_953 1188-0045 9.7 µM -0.431390543356644 0.340085995192383 no 2225 0.333092212402841 3266 6144426
SGTC_2620 irigenin 100 µM -0.431408472951245 0.340079110087089 no 2226 0.333085695095043 3315 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_86 0417-1630 471.922 µM -0.432245558763767 0.339757721954494 no 2227 0.332781475209885 3256 3634867
SGTC_520 3584-0023 682 µM -0.434454606219721 0.338910146794678 no 2228 0.331979175821169 3187 1340790
SGTC_3317 9138495 8.753 µM -0.434708963104435 0.338812606478423 no 2229 0.33188684581897 3213 17020139
SGTC_2293 7624732 200 µM -0.434940793777765 0.338723713886775 no 2230 0.331802701586772 3153 894453
SGTC_538 2922-0838 53.3 µM -0.435789462074628 0.33839837923035 no 2231 0.331494745112248 3326 777039
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.436642474899747 0.338071500622211 no 2232 0.331185326887676 3238 75037 A free radical scavenger.
SGTC_2205 7238770 200 µM -0.437248963749356 0.337839165401518 no 2233 0.330965401791384 3288 279867
SGTC_65 0798-0905 34.986 µM -0.439619329650081 0.336931713069445 no 2234 0.33010641921524 3509 3602145
SGTC_3229 9132204 49.47 µM -0.440252725262884 0.336689389188038 no 2235 0.329877038116529 3165 17682924
SGTC_1157 4092-0394 27.6 µM -0.441342553015282 0.336272602651989 no 2236 0.329482512100481 3364 3659885
SGTC_1217 1183-1422 255 µM -0.441844674661387 0.33608064221817 no 2237 0.329300804026226 3305 2849664
SGTC_2949 9072542 2.23 µM -0.443852632678998 0.335313430185138 no 2238 0.328574566276813 3257 16457352
SGTC_2652 actinonin 100 µM -0.444551574379796 0.335046535432736 no 2239 0.328321924892192 3158 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_43 0570-0105 72.5 µM -0.444828464987038 0.334940826244622 no 2240 0.328221860953768 3182 1114046 YDL195W SEC31
SGTC_2425 5628681 7.85 µM -0.445891947316921 0.334534939672758 no 2241 0.327837649680593 3245 5714958
SGTC_415 dibenzyl ketone 100 µM -0.446168002251805 0.334429612672998 no 2242 0.327737947257512 3243 7593
SGTC_1198 1612-1005 86.7 µM -0.448765046490938 0.333439365968304 no 2243 0.326800577949776 3366 6998509
SGTC_2580 diallyl disulphide 81.36 µM -0.450091597113163 0.332934002369665 no 2244 0.326322197739565 3188 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_232 clozapine 119 µM -0.45044794509843 0.332798299449985 no 2245 0.326193740283371 3232 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_898 1000-0849 28.3 µM -0.451160998459458 0.332526823281095 no 2246 0.325936758455995 3268 6751807
SGTC_3314 9135860 59.4275 µM -0.451397350565201 0.332436857851923 no 2247 0.325851596255018 3306 25252478
SGTC_53 0973-0023 39.979 µM -0.451542601878643 0.332381573956826 no 2248 0.325799263925532 3352 674768
SGTC_1354 1498-1681 81 µM -0.451990341244596 0.332211183464625 no 2249 0.325637970330096 3281 5754243
SGTC_1616 st002734 56.1 µM -0.452234478883451 0.332118289707535 no 2250 0.325550035954091 3172 4026101
SGTC_1391 3442-0225 151 µM -0.452398411044688 0.332055919721312 no 2251 0.325490995724208 3156 5227075
SGTC_2917 7979103 53.79 µM -0.452433377996902 0.332042616720687 no 2252 0.325478402929662 3314 2980565
SGTC_2972 9093619 59.92 µM -0.453086146603141 0.331794313075544 no 2253 0.325243355231827 3140 25236256
SGTC_843 0310-0051 143 µM -0.454322608074078 0.33132418374449 no 2254 0.324798323088435 3239 2065037
SGTC_1167 k781-0610 148 µM -0.454643108021077 0.331202366081058 no 2255 0.324683008235341 3211 4525169
SGTC_2134 5324836 1.464 µM -0.455537048056686 0.330862686075284 no 2256 0.324361460294248 3177 699272
SGTC_3169 9102970 49.47 µM -0.455925482991144 0.330715131645998 no 2257 0.324221782032772 3303 17027839
SGTC_1443 4112-3303 14 µM -0.456702368599862 0.330420095734792 no 2258 0.323942494072494 3218 704433
SGTC_1693 xanthone 101.9 µM -0.457063477835992 0.330282994041533 no 2259 0.323812710145777 3239 7020 An insecticide.
SGTC_3055 9094636 49.47 µM -0.457229414232676 0.330220000907054 no 2260 0.323753079204295 3381 25236176
SGTC_1409 3909-8004 61.9 µM -0.458718127179566 0.329655067893781 no 2261 0.323218297497947 3258 2119279
SGTC_895 0964-0006 13.7 µM -0.459398927424831 0.329396848904336 no 2262 0.322973859173993 3333 6738897
SGTC_2261 9010538 184.68 µM -0.459713716740483 0.329277480759527 no 2263 0.32286086129678 3295 6457250
SGTC_563 tetrahydrosecaminediol 614 µM -0.460835976976818 0.32885206121263 no 2264 0.322458143944412 3345 334274 A psychoactive constituent of the cannabis plant.
SGTC_3165 9101544 49.47 µM -0.460859869352761 0.328843006644562 no 2265 0.322449572549618 3288 5002184
SGTC_481 bay k-8644 50 µM -0.461495453332891 0.328602174299942 no 2266 0.322221591327621 3229 2303 A calcium channel antagonist.
SGTC_3257 9139206 32.98 µM -0.461808391248229 0.328483623552992 no 2267 0.322109366412064 3303 4910041
SGTC_1770 st043884 66.3 µM -0.462106163747727 0.328370833973012 no 2268 0.322002595132629 3243 670149
SGTC_430 0958-0115 16.4 µM -0.462431408160265 0.328247656516829 no 2269 0.32188599012893 3196 6833180
SGTC_2031 5180455 200 µM -0.462830092798885 0.328096691048513 no 2270 0.321743079625967 3219 29949
SGTC_999 SEC7.066 22.7 µM -0.463108762913619 0.327991186811439 no 2271 0.32164320458478 3198 740511 YDR170C SEC7
SGTC_1469 k284-2957 126 µM -0.464230683582683 0.327566567648933 no 2272 0.321241239995591 3261 23884841
SGTC_3098 9119039 49.47 µM -0.464425333024773 0.327492920339518 no 2273 0.321171521794128 3309 17161528
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.466491148728195 0.326711715134889 no 2274 0.320431990882742 3462 6728940
SGTC_1504 k297-0033 30 µM -0.467865563625674 0.326192389115435 no 2275 0.319940365510727 3145 4388117
SGTC_1025 k007-0731 70 µM -0.468198183196883 0.326066758586971 no 2276 0.319821435645201 3182 6256118
SGTC_806 3966-4455 5.86 µM -0.470971798754281 0.325019932741167 no 2277 0.3188304369789 3221 714982
SGTC_1150 3909-7983 10.9 µM -0.471578722436708 0.324791049607496 no 2278 0.318613758557954 3246 23965914
SGTC_1801 st050089 28.441 µM -0.472100482583917 0.324594336216222 no 2279 0.318427534018516 3309 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2136 5328288 199.296 µM -0.473182448339149 0.324186570730089 no 2280 0.318041509355644 3207 262395
SGTC_975 1335-0046 28.5 µM -0.475069795743682 0.323475782071423 no 2281 0.317368613080594 3232 16486740
SGTC_1299 1079-1439 3.74 µM -0.475693469978656 0.323241043215501 no 2282 0.317146386881374 3246 323161
SGTC_1557 sumaresinolic acid 42.3 µM -0.475733108063137 0.323226126588181 no 2283 0.317132265355577 3245 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1574 spiramycin 23.7 µM -0.475805341794293 0.323198944278778 no 2284 0.317106531938665 3234 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_564 3555-0129 330 µM -0.475899049175668 0.323163682616544 no 2285 0.317073149807113 3303 563260
SGTC_3323 9138564 53.9225 µM -0.477078141976113 0.322720131211515 no 2286 0.316653239413593 3384 43912313 YNL103W MET4
SGTC_1840 st055363 71 µM -0.477229542268326 0.32266319566598 no 2287 0.316599338315925 3275 676033
SGTC_2006 4011487 200 µM -0.477832470740452 0.322436499833985 no 2288 0.31638472409531 3376 45595294
SGTC_1796 st049173 110.4 µM -0.478442274663201 0.322207286031985 no 2289 0.31616772542007 3340 94134
SGTC_704 1310-0270 142 µM -0.478474360129591 0.322195227581029 no 2290 0.316156309561936 3279 5718033
SGTC_2791 5663188 71.43 µM -0.478991519349948 0.322000893161076 no 2291 0.315972330926106 3365 54690634
SGTC_3078 9116413 49.47 µM -0.479171219644937 0.321933378050178 no 2292 0.315908413475162 3215 17177322
SGTC_1250 0485-0349 40.2 µM -0.481091874411671 0.321212137269965 no 2293 0.3152256014321 3227 6842794 YDL195W SEC31
SGTC_1041 0206-0046 107 µM -0.481260500724248 0.321148847161712 no 2294 0.315165683171945 3272 50494
SGTC_597 k018-0003 82.8 µM -0.481736413343217 0.32097025204695 no 2295 0.314996602602894 3362 6786234
SGTC_945 3381-0768 11.3 µM -0.481966856260417 0.320883788909102 no 2296 0.314914745576069 3376 1126236 YIL048W NEO1
SGTC_2044 5102272 200 µM -0.482755445080018 0.320587980632698 no 2297 0.314634694962134 3331 592666
SGTC_2815 7968870 71.43 µM -0.485246013248731 0.319654490021705 no 2298 0.313750923007395 3276 2977326 YHR190W ERG9
SGTC_83 0170-0301 39.027 µM -0.485725321222203 0.319474971238916 no 2299 0.313580964108839 3316 3089716
SGTC_1176 0848-0131 83.3 µM -0.486732279543024 0.31909796546515 no 2300 0.313224033384391 3315 6769040
SGTC_950 1165-0508 94.1 µM -0.48674845483214 0.319091910952964 no 2301 0.313218301249236 3309 6148369
SGTC_1290 0986-0249 10.2 µM -0.48693212042899 0.31902316715323 no 2302 0.313153217725303 3295 53329
SGTC_1144 3486-0183 12.5 µM -0.486989865533636 0.319001555148629 no 2303 0.313132756440793 3288 6744069
SGTC_1081 sertraline 6 µM -0.487425109354967 0.318838678172303 no 2304 0.312978551534903 3372 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1358 1509-0022 2.48 µM -0.48759738015419 0.318774220642367 no 2305 0.312917525808975 3326 3258434
SGTC_2232 chlorophetanol 41.5365 µM -0.489454955633782 0.318079531377168 no 2306 0.312259818600888 3363 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_109 0132-0036 33.701 µM -0.49066197218674 0.317628478364105 no 2307 0.311832773467356 3282 67274 A color developer.
SGTC_3023 9089636 49.47 µM -0.490726499329456 0.317604372669098 no 2308 0.31180995073659 3405 17249241
SGTC_1763 st044482 94.5 µM -0.490846408877663 0.317559579573423 no 2309 0.311767541614268 3330 88505
SGTC_363 0455-0021 3.06 µM -0.491343017502157 0.317374096203332 no 2310 0.311591929671456 3291 4597466
SGTC_3094 9117742 49.47 µM -0.491748239887713 0.317222779571135 no 2311 0.31144866569387 3292 17149698
SGTC_1204 4049-0315 18.3 µM -0.492271531110762 0.317027419314452 no 2312 0.31126370141202 3437 588402
SGTC_2183 6420625 130.508 µM -0.49357370759784 0.316541499319372 no 2313 0.310803636577892 3377 2897619
SGTC_761 k216-0224 480 µM -0.493586436436669 0.316536750988283 no 2314 0.310799140879548 3426 1340404
SGTC_482 fipronil 114 µM -0.493664859036749 0.316507497103915 no 2315 0.310771443426017 3344 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2303 7774051 200 µM -0.493928162589295 0.316409285707258 no 2316 0.31067845718591 3407 2953184
SGTC_268 camptothecin 39.6153 µM -0.494002208632995 0.316381669097924 no 2317 0.31065230983776 3359 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_508 roscovitine 141 µM -0.496645627578098 0.315396437144455 no 2318 0.309719485628674 3335 160355 A CDKinase inhibitor.
SGTC_2682 pyrogallin 40.03 µM -0.496720372310642 0.315368597971285 no 2319 0.30969312706531 3303 822798 An ATP competetive kinase inhibitor.
SGTC_1287 0971-0001 34.6 µM -0.497571203740477 0.315051774047473 no 2320 0.30939315225636 3354 4665869
SGTC_177 1327-0068 8.361 µM -0.49864809548556 0.31465096713093 no 2321 0.309013658184495 3358 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1704 st028805 70.8 µM -0.498963167593886 0.314533742114991 no 2322 0.308902666036213 3332 2876101
SGTC_2028 5153890 36.43 µM -0.500390071887498 0.314003085519457 no 2323 0.308400221334285 3309 2830968 YPR165W RHO1
SGTC_3111 9122088 49.47 µM -0.503632335615604 0.312798738587196 no 2324 0.307259882681455 3263 16876704
SGTC_863 0466-0191 129 µM -0.504525521257239 0.312467312593405 no 2325 0.306946066280804 3377 765160 YPR165W RHO1
SGTC_1680 diphenhydramine 100 µM -0.505000939568065 0.312290965408231 no 2326 0.306779088029663 3275 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1404 3909-7820 48.3 µM -0.505364550571194 0.312156119982565 no 2327 0.306651406223041 3385 23741373
SGTC_2723 salbutamol 83.58 µM -0.506487209412123 0.311739939910097 no 2328 0.306257333272546 3357 9884233 β2-adrenoceptor agonist
SGTC_2844 9010103 25.97 µM -0.506617476568662 0.311691664214537 no 2329 0.306211621712535 3410 2480525
SGTC_2432 5630864 12.22 µM -0.510017850125938 0.310432666769123 no 2330 0.305019478171833 3398 5714970
SGTC_372 0155-0182 15.9 µM -0.510192270130615 0.310368146968708 no 2331 0.304958383534705 3319 771486
SGTC_693 4161-2696 114 µM -0.513328621050815 0.309208975027422 no 2332 0.303860733256611 3369 805759
SGTC_1074 carmofur 3.8 µM -0.513704885774173 0.309070037583656 no 2333 0.303729167775673 3387 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1151 3909-8316 15.3 µM -0.514175705713144 0.308896223663662 no 2334 0.303564575744802 3400 800431
SGTC_308 4092-1169 104 µM -0.514646602971643 0.308722423996013 no 2335 0.30339999653423 3330 2268590 YDL196W YDL196W
SGTC_674 0498-0004 451 µM -0.515085412018879 0.308560506059887 no 2336 0.303246668091605 3341 4231473
SGTC_753 1322-0200 289 µM -0.515362756684578 0.308458186717387 no 2337 0.303149776324828 3437 5403907
SGTC_2764 methyldopa 94.69 µM -0.51596026646607 0.308237801054515 no 2338 0.302941080311189 3467 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1587 estradiol valerate 56.1 µM -0.51760437840559 0.307631743251866 no 2339 0.302367163152602 3422 13791 A steroid.
SGTC_2429 5902844 64.44 µM -0.517607454408158 0.307630609857157 no 2340 0.30236608985647 3371 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3260 9137109 49.47 µM -0.518168079954551 0.307424070471831 no 2341 0.302170501780403 3316 17478346
SGTC_2464 5717415 7.67 µM -0.51836548190988 0.307351360383075 no 2342 0.302101646751092 3299 5285744
SGTC_3223 9129970 49.47 µM -0.519323018733823 0.306998773337681 no 2343 0.301767751962355 3331 17248386
SGTC_1724 st037281 8.293 µM -0.519326355521501 0.306997544967612 no 2344 0.301766588708678 3315 574124 YDL195W SEC31
SGTC_1726 st035556 14.5795 µM -0.520649053700655 0.306510791466537 no 2345 0.301305635374011 3461 5919439
SGTC_2876 9059903 25.97 µM -0.521383523296805 0.306240653589326 no 2346 0.301049813585152 3400 6916095
SGTC_2650 prasterone 100 µM -0.521639554865577 0.306146509936954 no 2347 0.300960658705822 3371 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_681 1642-0006 26.6 µM -0.522334801244275 0.305890930138385 no 2348 0.300718621264696 3415 4446530
SGTC_16 erodoxin 22.806 µM -0.522821226334808 0.305712171391321 no 2349 0.300549333421063 3429 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3143 9086658 49.47 µM -0.523659024300834 0.305404393435579 no 2350 0.300257860148596 3380 25236626
SGTC_1193 1488-0126 41.5 µM -0.524050802272343 0.305260514946172 no 2351 0.300121602883056 3361 1384710
SGTC_1246 0422-0085 105 µM -0.524665059251158 0.305034992725693 no 2352 0.299908025501801 3448 264295
SGTC_2731 amoxapine 43.43 µM -0.524824940973093 0.304976304869404 no 2353 0.299852445852616 3400 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1274 0865-0114 173 µM -0.525291209072551 0.304805180275034 no 2354 0.299690383807155 3341 870624
SGTC_3057 9095946 49.47 µM -0.525563691315334 0.304705196598091 no 2355 0.299595694800284 3382 24540043
SGTC_3072 9116419 49.47 µM -0.525856943444032 0.304597607987705 no 2356 0.29949380329823 3359 17170162
SGTC_1234 0326-0494 15.5 µM -0.526765673434294 0.304264319661021 no 2357 0.299178161615483 3460 1547813
SGTC_3154 9100113 49.47 µM -0.526840701305321 0.304236809491219 no 2358 0.299152107901595 3313 25237525
SGTC_59 0330-0160 1.33 µM -0.527480461207492 0.304002276299082 no 2359 0.298929990679855 3412 4293482
SGTC_2811 7967822 32.47 µM -0.527742818568208 0.30390612054393 no 2360 0.298838924910098 3412 2232244
SGTC_1991 st073000 8.92 µM -0.527855829060468 0.303864705610785 no 2361 0.298799702194066 3491 4301969 YIL048W NEO1
SGTC_573 3702-0553 84.7 µM -0.528221324581912 0.303730779778049 no 2362 0.298672865153248 3380 1222756
SGTC_1967 st070177 51.4 µM -0.528490558795177 0.303632143119612 no 2363 0.298579449105667 3458 5729214
SGTC_1208 2323-2347 50.3 µM -0.528753642112834 0.303535773719801 no 2364 0.298488180069945 3417 5412760
SGTC_633 0437-0093 97.7 µM -0.529262989120473 0.303349234911547 no 2365 0.298311513161193 3378 2831118
SGTC_120 rhodamine 6G 52.259 µM -0.52939358053946 0.303301416501363 no 2366 0.298266225221737 3308 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2835 9006588 71.43 µM -0.529497924546892 0.303263211477405 no 2367 0.298230041900682 3457 2345538
SGTC_1377 2944-0135 198 µM -0.529608133493498 0.303222861372337 no 2368 0.298191826968282 3376 1894137
SGTC_2448 5185112 27.17 µM -0.530869386666273 0.302761257756065 no 2369 0.297754646563695 3404 5718189
SGTC_2515 chrysin 20.77 µM -0.530931808949312 0.302738420120937 no 2370 0.29773301710842 3386 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_289 k017-0060 526 µM -0.531262164094874 0.30261757019689 no 2371 0.297618560277035 3337 5512909
SGTC_2446 5162541 200 µM -0.532217372682781 0.302268259201224 no 2372 0.297287725998086 3338 1549321
SGTC_3009 9080819 71.4286 µM -0.532413356458651 0.302196612110871 no 2373 0.297219868253563 3380 17027216
SGTC_1873 rapamycin 2 nM -0.532760215790391 0.302069827128071 no 2374 0.297099788464036 3375 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2831 7999036 19.48 µM -0.537052791067896 0.300502774262101 no 2375 0.295615574543551 3464 2988270
SGTC_1914 st062367 72.6 µM -0.538541226499905 0.299960262719249 no 2376 0.295101725572582 3332 978205
SGTC_463 ikarugamyin 104 µM -0.540411955225257 0.299279040559426 no 2377 0.294456482440966 3416 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2374 9071832 200 µM -0.54103577504169 0.299052033952861 no 2378 0.294241462262487 3433 17381698
SGTC_131 0141-0277 33.849 µM -0.542889668119915 0.298377868359761 no 2379 0.293602885019753 3442 1547771
SGTC_2150 5556613 200 µM -0.543607842517267 0.298116891274116 no 2380 0.293355680927622 3365 743190
SGTC_545 4218-0007 221 µM -0.544572839043767 0.297766385442757 no 2381 0.293023669698213 3436 2840508
SGTC_3259 9138485 49.47 µM -0.545022434099999 0.297603147841608 no 2382 0.292869044126046 3591 17646153
SGTC_1608 st001473 40.5 µM -0.545383290723959 0.29747215867497 no 2383 0.292744965046788 3332 7292267
SGTC_867 0518-0118 155 µM -0.545725713443039 0.297347885274531 no 2384 0.292627246968299 3443 6848158
SGTC_1080 nisoldipine 24.4 µM -0.548568104290275 0.296317230461398 no 2385 0.291650939871171 3340 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2155 5570423 76 µM -0.548728760456316 0.296259025256693 no 2386 0.291595802905115 3337 797402
SGTC_1675 st018485 24.5 µM -0.54886873854812 0.296208315925941 no 2387 0.29154776658683 3367 3323024
SGTC_2589 lobaric acid 100 µM -0.548890990963428 0.296200254994907 no 2388 0.291540130559616 3353 73157 A novel microtubule depolymerizer.
SGTC_3123 9126162 49.47 µM -0.549032169996439 0.296149115275558 no 2389 0.291491686443896 3409 25239884
SGTC_90 0870-0863 4.608 µM -0.551643320530132 0.29520400136936 no 2390 0.290596374970668 3405 1738164
SGTC_647 0140-0236 81 µM -0.552175269041735 0.295011631364518 no 2391 0.290414138300888 3414 990837
SGTC_331 k048-0133 24.5 µM -0.553771202610035 0.294434836337911 no 2392 0.289867719428799 3408 6813582
SGTC_3282 9108498 15.4605 µM -0.554108764570908 0.294312902966647 no 2393 0.289752206115263 3407 16459645
SGTC_335 4077-0256 27.6 µM -0.554258073750886 0.294258977280571 no 2394 0.289701119576942 3448 3121989
SGTC_659 k018-0002 107 µM -0.554302975621962 0.294242761057838 no 2395 0.289685757107548 3464 6797879 YHR007C ERG11
SGTC_982 1491-0518 27.5 µM -0.555436630109853 0.293833480813587 no 2396 0.289298021790559 3354 3091256
SGTC_1874 staurosporine 7.6 µM -0.55588094366526 0.293673143347362 no 2397 0.289146123123195 3459 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3272 9137413 49.47 µM -0.558240181811633 0.292822454720348 no 2398 0.288340192955533 3417 17614870
SGTC_2899 9053889 58.44 µM -0.55896133557544 0.292562651244056 no 2399 0.288094053953007 3447 6470052
SGTC_764 1951-2361 146 µM -0.559077415571917 0.292520842174637 no 2400 0.28805444363209 3347 5438930
SGTC_1252 0493-0875 34.8 µM -0.559126393437828 0.292503202423057 no 2401 0.288037731540966 3402 3960963
SGTC_500 h-89 112 µM -0.559860653064061 0.292238812506724 no 2402 0.28778724438882 3513 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2644 guaiazulene 100 µM -0.560275009411657 0.292089661452204 no 2403 0.287645935270298 3448 3515 A coloring agent.
SGTC_2898 9056270 58.44 µM -0.563905180489565 0.29078446835418 no 2404 0.286409332114872 3421 19154699
SGTC_837 0091-0265 12.5 µM -0.564454880335169 0.290587067029053 no 2405 0.286222299259453 3388 759367
SGTC_433 pimozide 108 µM -0.564801101891486 0.29046276846929 no 2406 0.286104528739419 3314 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3066 9117245 49.47 µM -0.566535444625897 0.289840489176654 no 2407 0.285514922527251 3422 17176980
SGTC_1741 st038134 10.228 µM -0.566936180460071 0.289696794815763 no 2408 0.285378770900915 3561 1272587
SGTC_3355 9151058 44.0485 µM -0.567269300740909 0.289577371241709 no 2409 0.285265615474014 3479 17015728
SGTC_2696 st077691 74.316 µM -0.567519555801597 0.289487670045042 no 2410 0.285180622050172 3466 757133
SGTC_1082 camptothecin 424.86 nM -0.568404746690136 0.289170487790397 no 2411 0.284880084033588 3315 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1561 5-methoxyflavone 52.9 µM -0.568858967966917 0.289007794344478 no 2412 0.284725926528589 3444 94525
SGTC_1111 tnp00062 510.699 nM -0.569495324593662 0.288779935920543 no 2413 0.284510021358584 3519 676306
SGTC_2431 5490079 200 µM -0.570266380364476 0.28850395953373 no 2414 0.284248519847061 3424 5722345
SGTC_228 caffeine 993.056 µM -0.570708023096563 0.288345942708318 no 2415 0.284098789664049 3491 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_399 oxolinic acid 75 µM -0.570956850106178 0.288256932039006 no 2416 0.284014446434109 3387 4628 A DNA gyrase inhibitor.
SGTC_949 1165-0505 146 µM -0.571104788767744 0.288204017403208 no 2417 0.283964306333125 3421 6244267
SGTC_2887 9044784 58.44 µM -0.571139069596911 0.288191756505151 no 2418 0.283952688309892 3473 6465546
SGTC_1432 4049-0298 68.4 µM -0.572406409801293 0.287738651787213 no 2419 0.283523337190264 3482 741646
SGTC_2268 7933382 153.85 µM -0.572586693588399 0.287674223336714 no 2420 0.283462285705578 3500 935025 YOR257W CDC31
SGTC_3233 9132340 49.47 µM -0.573657289700089 0.287291762351754 no 2421 0.283099867825061 3403 17682950
SGTC_3228 9131799 49.47 µM -0.574382593469806 0.287032790794921 no 2422 0.28285446462675 3430 17015818
SGTC_2750 bromebric acid 70.15 µM -0.575004991749761 0.286810650086744 no 2423 0.282643960514693 3493 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_486 niguldipine 82 µM -0.575180061203734 0.286748180583145 no 2424 0.282584763060707 3447 1236 A calcium channel blocker.
SGTC_821 1114-0266 29.2 µM -0.575890036260112 0.286494908474583 no 2425 0.28234475536359 3464 3123235
SGTC_2453 5731132 22.18 µM -0.578830497752836 0.285447078149989 no 2426 0.281351775281036 3529 1362040
SGTC_2405 ticlatone 3.52 µM -0.580778063746664 0.28475407113975 no 2427 0.280695020621422 3303 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2629 bisabolol 100 µM -0.580817962260666 0.284739882354689 no 2428 0.280681573872232 3515 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1125 tnp00248 1.32998 µM -0.580891191463537 0.284713841325019 no 2429 0.280656894698119 3512 24207736
SGTC_1714 st033236 13.627 µM -0.581098469548499 0.284640137348895 no 2430 0.280587045034748 3559 2916566
SGTC_2919 7978188 46.38 µM -0.581985541615325 0.284324815070109 no 2431 0.280288209873914 3518 2980291
SGTC_2458 5808907 16.39 µM -0.58214666357252 0.284267559918416 no 2432 0.280233947960603 3572 2731747
SGTC_2526 patulin 37.61 µM -0.582620710479179 0.284099137954377 no 2433 0.280074330136735 3519 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2304 7443016 91.4 µM -0.582875395830288 0.284008671670726 no 2434 0.279988592432552 3459 939854
SGTC_609 0986-0026 86.3 µM -0.583037034412079 0.283951263497722 no 2435 0.279934184750505 3483 2848610
SGTC_572 0960-0087 17.7 µM -0.583107606265346 0.283926200671727 no 2436 0.279910431813472 3437 6796365
SGTC_2754 granisetron 64.02 µM -0.583566311375293 0.283763322351245 no 2437 0.279756065567603 3523 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_299 1273-0059 1.44 µM -0.584245364459081 0.283522284416398 no 2438 0.279527622335057 3474 2848077
SGTC_2536 dehydroabietamide 32.04 µM -0.584320335583464 0.283495678543363 no 2439 0.27950240652267 3524 3983547
SGTC_2605 digitonin 300 nM -0.584367916034634 0.283478793737135 no 2440 0.279486403871203 3572 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1225 1216-0074 20.6 µM -0.585408915941145 0.2831094962842 no 2441 0.279136397560004 3433 4241466
SGTC_1969 st069479 40.1 µM -0.585936123077342 0.282922556275144 no 2442 0.278959220631697 3505 3895485
SGTC_1803 st050068 52.4 µM -0.586347449367247 0.28277674710819 no 2443 0.278821025434575 3569 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2066 5222451 176 µM -0.589070555157688 0.281812357548005 no 2444 0.277906972329603 3491 2281147
SGTC_488 nitrendipine 139 µM -0.589373967851445 0.281705001981924 no 2445 0.277805217739797 3512 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2119 5528445 120.635 µM -0.589436809437235 0.281682769404776 no 2446 0.277784145023041 3514 791935
SGTC_795 0685-0265 78 µM -0.589638617332597 0.281611377984284 no 2447 0.27771647790643 3576 302754
SGTC_1949 st076024 69.1 µM -0.590661389010939 0.281249697222944 no 2448 0.277373661694603 3440 2921930
SGTC_1380 2291-0730 164 µM -0.590960175229902 0.281144080378944 no 2449 0.277273552543159 3445 2999191
SGTC_1810 st050138 53 µM -0.591041381218472 0.281115378483177 no 2450 0.277246347305875 3516 3444541
SGTC_2018 5133068 143 µM -0.59115770617177 0.281074266411468 no 2451 0.277207378957854 3493 785362
SGTC_1951 sophoraflavanone G 9.2 µM -0.591256199045823 0.281039458901916 no 2452 0.277174386372926 3458 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_668 1682-0499 62.6 µM -0.592845677627663 0.280478023299187 no 2453 0.276642217671448 3476 682214
SGTC_254 nsc-64875 3.808 µM -0.594059882612932 0.280049507918372 no 2454 0.276236030878732 3525 56993
SGTC_1265 0819-1001 68.8 µM -0.594532975081743 0.279882630796303 no 2455 0.276077846991142 3524 3106768
SGTC_1864 st057645 30.4 µM -0.59491824186684 0.279746768662797 no 2456 0.275949061491009 3547 688666
SGTC_622 1348-1566 26.3 µM -0.595338975914014 0.279598435765189 no 2457 0.275808453846487 3500 7340407
SGTC_557 1315-0110 16.2 µM -0.59613550682616 0.279317717514097 no 2458 0.275542352840639 3500 6833801
SGTC_2245 6637752 200 µM -0.597557093514583 0.278817053873663 no 2459 0.275067750359154 3476 681890
SGTC_2470 5664817 21.68 µM -0.601560627987857 0.277409414546166 no 2460 0.273733321720056 3535 2859561
SGTC_798 1287-0182 476 µM -0.605220527874864 0.276125644088667 no 2461 0.272516238965058 3561 1649755
SGTC_1957 st077035 62.4 µM -0.605585434280024 0.275997807186253 no 2462 0.27239503849221 3581 705593
SGTC_2273 7815444 169.05 µM -0.60694265921546 0.275522588642256 no 2463 0.271944483212711 3527 2824616
SGTC_1012 4112-3522 18 µM -0.607309855279389 0.275394087868408 no 2464 0.271822649603285 3535 3112398
SGTC_3082 9117008 49.47 µM -0.608153227064142 0.275099060428068 no 2465 0.271542926409204 3476 41448529
SGTC_2689 tacrolimus 100 µM -0.608310596009554 0.275044027024654 no 2466 0.271490747339221 3499 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1774 st048371 48.465 µM -0.608586189083911 0.274947662595501 no 2467 0.27139938054131 3470 4242727
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.610985071821417 0.274109567738939 no 2468 0.270604731594708 3539 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3293 9120939 62.045 µM -0.61305771830959 0.273386467429955 no 2469 0.269919088085196 3543 934087
SGTC_916 4466-0038 42 nM -0.61337802455993 0.273274804017851 no 2470 0.269813206541635 3609 5722064 YGL116W CDC20
SGTC_1357 1503-1303 39.5 µM -0.614155835362455 0.273003741947088 no 2471 0.269556177305138 3536 292895
SGTC_1640 st009078 66.4 µM -0.615503165894153 0.272534521554907 no 2472 0.2691112395963 3551 690618
SGTC_1298 1079-1278 263 µM -0.620353881322524 0.270848537611839 no 2473 0.267512414194641 3557 2840950
SGTC_2479 5617353 43.85 µM -0.621231958248715 0.270543898041179 no 2474 0.267223507515196 3587 2731746
SGTC_3296 9122258 64.045 µM -0.621455541586713 0.270466355500893 no 2475 0.26714996882542 3539 4730474
SGTC_2256 7954252 200 µM -0.622175482944013 0.270216742956713 no 2476 0.26691324268475 3504 2972920
SGTC_344 k064-0035 6.43 µM -0.622432753511137 0.270127572026804 no 2477 0.26682867446197 3486 5088750
SGTC_3352 9151559 45.5865 µM -0.6236101138347 0.269719682493181 no 2478 0.266441833454298 3498 17159339
SGTC_637 1181-0519 7.26 µM -0.625456081997016 0.269080779321966 no 2479 0.265835882073552 3562 6252091 YGR060W ERG25
SGTC_657 3534-0529 86.7 µM -0.625788441525528 0.268965827974942 no 2480 0.265726857079739 3572 1049549
SGTC_2001 4023502 57.655 µM -0.626554849539401 0.26870084868677 no 2481 0.265475536164263 3547 108941 YCR052W RSC6
SGTC_1310 1188-0297 994 nM -0.626759617819996 0.268630073941315 no 2482 0.265408408863856 3533 1588352
SGTC_80 0159-0065 512.242 µM -0.627973112582396 0.268210842040631 no 2483 0.265010776901193 3532 1548079
SGTC_1581 himbacine 57.9 µM -0.628956501272053 0.267871347652926 no 2484 0.264688767130359 3546 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1938 st074717 56.4 µM -0.629321643949242 0.267745344905376 no 2485 0.26456925215854 3480 17250979
SGTC_1285 0929-0069 65.5 µM -0.629794784903205 0.267582118749227 no 2486 0.264414429080575 3542 1206237
SGTC_3211 9128781 49.47 µM -0.630299865575911 0.267407929271466 no 2487 0.264249205463922 3500 17194361
SGTC_2355 9061122 103.12 µM -0.630801256312082 0.267235068947809 no 2488 0.264085240927164 3532 5302957
SGTC_2337 9009472 200 µM -0.631070748866094 0.267142181542824 no 2489 0.263997133035392 3615 5742383
SGTC_3350 9150499 3.57 µM -0.632586280855368 0.266620118959083 no 2490 0.263501924192936 3557 4910996 YPR165W RHO1
SGTC_1822 st052468 42 µM -0.632738455627758 0.266567727097045 no 2491 0.263452226410715 3520 2873678
SGTC_943 3253-1379 105 µM -0.633634891495611 0.266259201195724 no 2492 0.26315956231531 3574 668464
SGTC_1091 telmisartan 47.6 µM -0.634910157468105 0.265820605196402 no 2493 0.262743505989219 3635 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3280 9140961 49.47 µM -0.635731321455218 0.265538380210982 no 2494 0.262475778921045 3531 4901226
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.636664749383674 0.265217756042764 no 2495 0.26217161972689 3628 1377
SGTC_2941 9056145 11.23 µM -0.638714038819596 0.264514533586309 no 2496 0.261504489094955 3502 2119517
SGTC_1060 3448-7350 82 µM -0.638868136113301 0.264461692818456 no 2497 0.261454359145664 3548 570178
SGTC_2830 7992007 71.43 µM -0.639832350855221 0.264131180554689 no 2498 0.261140799026893 3525 1952075
SGTC_1084 voriconazole 435 nM -0.639907822675855 0.264105319305493 no 2499 0.261116263946342 3581 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2546 rhodinyl acetate 100 µM -0.639974709863401 0.264082400753501 no 2500 0.261094520628453 3578 6708682
SGTC_1325 1431-0015 227 µM -0.641573627204807 0.263534841712851 no 2501 0.260575030580155 3522 1103340
SGTC_1703 st026983 48.3 µM -0.641717214063173 0.263485697879946 no 2502 0.260528405099809 3606 1104023
SGTC_1753 st043925 64 µM -0.64272732152261 0.263140112187622 no 2503 0.260200524761087 3579 670181
SGTC_3132 9126706 49.47 µM -0.642853940303034 0.263096808741702 no 2504 0.260159439378144 3608 850858
SGTC_542 3381-0244 89.3 µM -0.643130897527771 0.263002102453137 no 2505 0.260069583690708 3600 1112843
SGTC_226 1,3-diallylurea 8.28947 mM -0.643467578319742 0.262886996996961 no 2506 0.259960372909668 3548 74537 YKL182W FAS1
SGTC_3160 9100216 49.47 µM -0.644257029350962 0.262617198116767 no 2507 0.25970438763419 3547 17191039
SGTC_2377 9073351 62.6 µM -0.644613580428716 0.262495391448719 no 2508 0.25958881600108 3542 7337946 YHR072W ERG7
SGTC_44 0929-0055 61.211 µM -0.646706710809752 0.261780910026786 no 2509 0.258910889509282 3516 1379590
SGTC_1630 st005209 31.3 µM -0.647042815387107 0.26166627514444 no 2510 0.258802116814249 3603 3367314
SGTC_1257 0669-0121 16 µM -0.64707457914219 0.261655442841831 no 2511 0.258791838411736 3622 4307855
SGTC_1792 st045773 43.6 µM -0.648843734965005 0.261052476253151 no 2512 0.258219692738717 3551 2919270
SGTC_2154 5570129 200 µM -0.649323344548662 0.260889138089487 no 2513 0.258064699864043 3607 673366
SGTC_379 3970-0972 5.9 µM -0.649338691063662 0.26088391247401 no 2514 0.258059741209245 3583 2898042 YBL034C STU1
SGTC_979 1426-2828 121 µM -0.649450226438878 0.260845935372417 no 2515 0.258023704191096 3641 747872
SGTC_1999 st074831 12.5 µM -0.649818202304006 0.26072066205002 no 2516 0.257904829905704 3570 17112523
SGTC_3000 9075062 71.4286 µM -0.649865864028316 0.260704438406973 no 2517 0.257889434905678 3569 17057871
SGTC_2201 6605497 169.863 µM -0.651077691048577 0.260292117461839 no 2518 0.257498168333212 3594 670741
SGTC_691 1548-0686 185 µM -0.652550030678199 0.25979161027919 no 2519 0.257023204452964 3569 46495133
SGTC_3074 9116018 49.47 µM -0.652856894271596 0.259687357630547 no 2520 0.256924270361342 3626 17027303
SGTC_188 3229-0966 278.469 µM -0.653053443325935 0.259620594162917 no 2521 0.256860912545153 3677 5722370
SGTC_2153 5569715 200 µM -0.654143783419978 0.259250390178642 no 2522 0.256509587867256 3614 2054701
SGTC_2007 4011539 71.82 µM -0.655158920536708 0.258905965325158 no 2523 0.256182719932961 3608 45595301
SGTC_111 0083-0039 52.457 µM -0.657117756925477 0.258242023429102 no 2524 0.255552601044957 3531 759313
SGTC_2516 gossypol 71.55 µM -0.657324012323306 0.258172165152468 no 2525 0.255486299909947 3625 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3321 9137793 26.8275 µM -0.65939162002191 0.25747241246097 no 2526 0.254822160969278 3612 4904192
SGTC_1911 st060208 74.3 µM -0.659807193909033 0.257331886347254 no 2527 0.254688783103049 3615 688783
SGTC_958 1222-0007 33 µM -0.661051935137682 0.256911216308137 no 2528 0.254289503965809 3679 7312461
SGTC_3028 9087778 49.47 µM -0.662881621752795 0.256293509592756 no 2529 0.253703186517745 3571 17217395
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.663046819983305 0.256237776391647 no 2530 0.253650284216648 3661 5024745
SGTC_327 1273-0057 3.96 µM -0.663087076132112 0.25622419606546 no 2531 0.253637393655681 3559 3108138
SGTC_2864 9034755 47.6 µM -0.663447831717225 0.256102512687317 no 2532 0.253521890218863 3617 4930451
SGTC_1442 4112-3290 3 µM -0.665606284948362 0.255375093423635 no 2533 0.252831394066745 3606 704353
SGTC_3267 9137951 49.47 µM -0.665839116359527 0.255296691596908 no 2534 0.252756969748773 3607 16643986
SGTC_1007 4101-0031 70 µM -0.667065047360056 0.254884088824057 no 2535 0.252365292530414 3594 1146276
SGTC_37 0566-0070 1.56 µM -0.667995123005672 0.254571292944855 no 2536 0.252068352808492 3631 1626686
SGTC_2047 4141938 200 µM -0.670494603507929 0.253731684273409 no 2537 0.251271272713178 3602 3807862
SGTC_783 0848-0141 92.7 µM -0.670704572095252 0.253661219301435 no 2538 0.251204374818459 3619 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_872 0588-0139 234 µM -0.67075025077945 0.253645891002005 no 2539 0.251189822423288 3643 2047100
SGTC_2782 7736369 71.43 µM -0.672480313974449 0.25306569568778 no 2540 0.250638984249627 3676 2950836 YOL077C BRX1
SGTC_3155 9099265 49.47 µM -0.672687556370336 0.252996241576625 no 2541 0.250573042880958 3583 25236499
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.672936843933178 0.252912709963128 no 2542 0.250493735560488 3654 6708561
SGTC_1843 st055809 45.5 µM -0.673374710402253 0.25276602422164 no 2543 0.250354466728127 3622 16413835
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.673518079783786 0.252718005060043 no 2544 0.250308875249345 3725 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1594 piperine 70.1 µM -0.675156347415996 0.252169636143098 no 2545 0.249788218649172 3638 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2507 purpurin 79.67 µM -0.6769273170411 0.251577555200649 no 2546 0.249226035546247 3629 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2729 fluphenazine 10.66 µM -0.677418307441539 0.25141353454143 no 2547 0.24907029296422 3587 3372 An atypical antipsychotic.
SGTC_1497 4476-2978 41.3 µM -0.677931287294181 0.251242228460077 no 2548 0.248907630632727 3657 1528379
SGTC_3011 9081274 71.4286 µM -0.678226569714546 0.25114364893087 no 2549 0.248814024284538 3640 6625322
SGTC_2133 5320837 200 µM -0.678744497557059 0.250970789036219 no 2550 0.248649883240395 3623 2841355
SGTC_2319 6033012 152.6 µM -0.680090804863519 0.250521749847196 no 2551 0.248223483165377 3612 847246
SGTC_2301 7769476 200 µM -0.680544391852813 0.250370559117817 no 2552 0.248079911759458 3644 977820
SGTC_2152 5568786 200 µM -0.680929552563498 0.250242214386425 no 2553 0.247958033737038 3622 5399883
SGTC_725 1497-0963 19 µM -0.6814163624853 0.250080047641684 no 2554 0.247804036154412 3669 3549977
SGTC_1475 4092-1048 11.7 µM -0.681516256360701 0.250046777761249 no 2555 0.247772442013867 3652 2881759
SGTC_1119 parthenolide 318.541 nM -0.681799109890942 0.249952585495439 no 2556 0.247682993600763 3730 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1872 amphotericin b 148 nM -0.682646167656977 0.249670621819953 no 2557 0.247415226793532 3660 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_371 0195-0006 7.36 µM -0.683791790258137 0.249289542526015 no 2558 0.247053325727684 3550 3928593
SGTC_2795 7780010 54.55 µM -0.685215728574738 0.248816315856834 no 2559 0.246603900049198 3632 953673
SGTC_2513 baicalein 25.65 µM -0.68589732533254 0.248589965747158 no 2560 0.24638892847648 3626 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1359 1582-0056 520 nM -0.686891540770191 0.24825999552079 no 2561 0.2460755390136 3687 3661189
SGTC_1782 st039423 80.636 µM -0.688643173121083 0.247679214796764 no 2562 0.245523922636926 3648 2068169
SGTC_1508 1080-0625 72.9 µM -0.6887252604428 0.247652015289491 no 2563 0.245498088362638 3597 767111
SGTC_2688 kanamycin b 96.69 µM -0.689118801670268 0.247521638172518 no 2564 0.245374254541518 3774 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1620 st003704 16.5 µM -0.689748512983764 0.24731309607219 no 2565 0.245176176013936 3638 2834414
SGTC_956 1185-0240 191 µM -0.690093817010637 0.247198781293578 no 2566 0.245067595591012 3666 1416193
SGTC_1868 st057644 42.7 µM -0.690189430671202 0.247167132866606 no 2567 0.245037534567313 3670 688665
SGTC_1643 st009866 20.2 µM -0.690907266299623 0.246929596203199 no 2568 0.244811909741329 3660 3156273 YOR207C RET1
SGTC_1709 st033179 39.1045 µM -0.691855112284266 0.246616134809188 no 2569 0.244514161143678 3651 573381
SGTC_1679 SEC14.276 6.7 µM -0.693383904401712 0.246110998631307 no 2570 0.24403433023832 3695 1005053 YMR079W SEC14
SGTC_2396 5342950 42.78 µM -0.696339396560299 0.245136034589873 no 2571 0.243108153212454 3670 1886677
SGTC_893 0958-0369 48.9 µM -0.697067116083377 0.244896292006929 no 2572 0.242880396172803 3684 6819948
SGTC_1775 st081588 35.1725 µM -0.697988250293945 0.244593011210025 no 2573 0.24259227107231 3705 1426443 YGL099W LSG1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.69801295927156 0.244584878636827 no 2574 0.242584544806344 3739 6710655
SGTC_2964 9083345 53.42 µM -0.698997528452948 0.244260941655664 no 2575 0.242276787709736 3644 17741579
SGTC_1022 4477-0945 21.3 µM -0.699550947675442 0.244078960606833 no 2576 0.242103892613182 3661 4648966
SGTC_1710 st031758 61.5 µM -0.699677874993937 0.244037233360644 no 2577 0.242064248362672 3692 5394341
SGTC_2284 7945075 39.21 µM -0.701121621053743 0.243562874011788 no 2578 0.241613559163809 3743 1245402
SGTC_734 2023-0417 80 µM -0.701158110825254 0.243550891334057 no 2579 0.2416021741843 3642 3935732
SGTC_981 1488-1094 54.9 µM -0.702031284864528 0.243264249450747 no 2580 0.241329826695223 3661 3449522
SGTC_1147 3809-1045 12.3 µM -0.70339783202946 0.242816011380402 no 2581 0.240903928613873 3646 325925
SGTC_3309 9129340 25.759 µM -0.703895296328407 0.242652950273075 no 2582 0.240748990462938 3710 17158987
SGTC_1746 st038117 42 µM -0.704123417510581 0.242578195507727 no 2583 0.240677958932658 3704 2898218
SGTC_944 3370-0224 231 µM -0.704858354260317 0.242337443328845 no 2584 0.240449194638108 3701 4580514
SGTC_2719 novobiocin 32.65 µM -0.706415761086995 0.241827692800376 no 2585 0.23996481110631 3680 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_902 1120-0002 2.07 µM -0.709661783382598 0.24076711889593 no 2586 0.238956948220842 3689 3280475
SGTC_229 benomyl 22.8748 µM -0.709826372064381 0.240713410288897 no 2587 0.238905906535311 3689 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2354 9060492 162 µM -0.709998810706139 0.240657147076748 no 2588 0.238852436842936 3726 6471895
SGTC_1907 st060210 83.7 µM -0.710091811700057 0.240626805720724 no 2589 0.238823601855971 3705 688793
SGTC_2521 angolensin 13.4 µM -0.711541194164374 0.240154217312785 no 2590 0.238374466532418 3707 821428 A flavenoid.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.711667417653936 0.240113084602004 no 2591 0.23833537424539 3678 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1961 st076550 68.7 µM -0.712960336216852 0.239691979760877 no 2592 0.237935150683148 3675 1579337
SGTC_82 0054-0107 293.755 µM -0.713315447965476 0.23957639010675 no 2593 0.237825290206956 3694 3104697
SGTC_1324 1418-0026 34.4 µM -0.714435736534758 0.239211933219529 no 2594 0.237478890322617 3745 1372513
SGTC_96 0929-0093 37.281 µM -0.71558834287014 0.238837278993146 no 2595 0.237122786841158 3669 6991579
SGTC_2342 7990637 118.86 µM -0.715839670995781 0.23875562752962 no 2596 0.23704517674262 3759 2033102 YER133W GLC7
SGTC_3226 9131256 49.47 µM -0.716184044574915 0.238643772268642 no 2597 0.23693885689001 3603 17178073
SGTC_6 0844-0013 19.835 µM -0.71858765560975 0.237863859569761 no 2598 0.236197510777677 3802 1584900
SGTC_2211 7117706 200 µM -0.71994830632481 0.237422982179791 no 2599 0.235778412038468 3644 822771
SGTC_1077 5-fluorocytosine 377 nM -0.720111824810812 0.237370029212118 no 2600 0.235728073756187 3718 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3238 9133470 49.47 µM -0.720258184234164 0.237322638445461 no 2601 0.235683022825347 3702 3534688
SGTC_1027 k015-0025 8.67 µM -0.724138351544432 0.236068147918164 no 2602 0.234490400793293 3689 3598955
SGTC_1263 0774-1208 64.8 µM -0.72438160759301 0.235989623094156 no 2603 0.234415744129059 3741 906585
SGTC_790 1575-0012 79.1 µM -0.725893949299764 0.235501751247675 no 2604 0.233951893049967 3790 378741 YLR208W SEC13
SGTC_1266 0828-0227 32.9 µM -0.726990974654721 0.235148206371453 no 2605 0.233615742309791 3731 3913820
SGTC_793 0488-0545 106 µM -0.727191288973636 0.235083681549871 no 2606 0.233554390882446 3719 292548
SGTC_1424 4048-1941 275 µM -0.727520274112982 0.23497773078222 no 2607 0.233453650087759 3805 X1424
SGTC_1578 josamycin 24.2 µM -0.728916626963282 0.234528324442067 no 2608 0.233026331696536 3690 5282165 A P450 substrate.
SGTC_2409 alverine citrate 63.97 µM -0.729298887426611 0.234405379549016 no 2609 0.232909426347994 3871 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3180 9109287 49.47 µM -0.732524867600631 0.233369242269741 no 2610 0.231924135089403 3724 18891271
SGTC_2679 rapamycin 1 nM -0.735810054434855 0.232316705405114 no 2611 0.230923150750904 3714 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_938 3126-1755 342 µM -0.738325977547699 0.231512421037467 no 2612 0.230158192105319 3727 1777771
SGTC_71 0417-1750 47.813 µM -0.73892063936855 0.231322548011248 no 2613 0.22997759436301 3692 6811472
SGTC_2736 butenafine 14.65 µM -0.739518084487082 0.231131873788163 no 2614 0.229796231234689 3709 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2434 5670830 169.91 µM -0.739735672799532 0.23106245241275 no 2615 0.229730199047458 3771 1549830
SGTC_1921 5740136 50 µM -0.741079127106567 0.230634082248291 no 2616 0.229322732315106 3702 1774243
SGTC_2504 purpurogallin 52.29 µM -0.742615732371421 0.230144668977013 no 2617 0.228857180450832 3690 5281571 An antioxidant.
SGTC_917 harmaline 728.087 nM -0.74264504075745 0.230135339820365 no 2618 0.228848305922317 3757 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2524 avocatin b 10.57 µM -0.743994497544368 0.229706023231774 no 2619 0.228439901994575 3709 6710748
SGTC_2568 diosmetin 100 µM -0.744264574814502 0.229620154668466 no 2620 0.228358214151938 3741 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_747 3448-8087 38.7 µM -0.745271873918325 0.229300051909389 no 2621 0.228053690284271 3787 5168703
SGTC_2270 7924575 90.91 µM -0.746341261558496 0.228960492412554 no 2622 0.227730646072587 3763 1262135
SGTC_1120 ficusin 1.78878 µM -0.746371816368189 0.228950794581966 no 2623 0.227721419759359 3850 6199 A DNA cross-linker.
SGTC_2593 nobiletin 86.24 µM -0.746518485166718 0.228904246391022 no 2624 0.227677134660198 3744 72344 An anti-infammatory.
SGTC_3311 9131146 2.8755 µM -0.746625390653604 0.228870321205778 no 2625 0.227644858729225 3757 4900406 YPR165W RHO1
SGTC_3133 9127736 49.47 µM -0.747325734128895 0.228648145340454 no 2626 0.227433481129545 3744 27243420
SGTC_888 0916-0002 6.97 µM -0.74735153917011 0.22863996130389 no 2627 0.227425694766962 3828 2802138 YIL048W NEO1
SGTC_923 1900-2434 73.3 µM -0.747414961027507 0.228619847840104 no 2628 0.227406558618014 3733 5910570
SGTC_1688 st021091 57.6 µM -0.748055095227449 0.228416892773665 no 2629 0.227213463006071 3785 3656366
SGTC_195 4234-0266 16.654 µM -0.748381107160654 0.228313569347291 no 2630 0.227115157475574 3750 2303354
SGTC_33 0986-0033 35.816 µM -0.749328526273482 0.228013451600199 no 2631 0.226829609159953 3683 2848082
SGTC_824 1304-0008 100 µM -0.74966030118016 0.227908406415795 no 2632 0.22672966143751 3768 768245
SGTC_2804 7954240 19.48 µM -0.753161178625027 0.226801634095703 no 2633 0.225676532335066 3775 828705
SGTC_350 k064-0020 19.8 µM -0.75369363642355 0.226633568209754 no 2634 0.225516601942306 3723 2790705
SGTC_2709 st078560 56 µM -0.753965687690195 0.226547724625058 no 2635 0.225434912692277 3747 17250903
SGTC_1626 st003712 1.76 µM -0.755808363796513 0.225966766499442 no 2636 0.22488205070762 3723 24207035
SGTC_1004 4084-0029 199 µM -0.756786509815246 0.225658719590208 no 2637 0.224588888077812 3793 716894 YLR208W SEC13
SGTC_225 nsc-122657 1.016 µM -0.757090301025569 0.225563095194349 no 2638 0.224497882186178 3753 275685
SGTC_966 1300-0360 30.2 µM -0.757252946108983 0.225511908808782 no 2639 0.224449167650619 3760 70588
SGTC_968 1309-0633 340 µM -0.757416629910802 0.22546040216414 no 2640 0.224400148061075 3763 3761976
SGTC_2905 7799065 20.05 µM -0.757641952541071 0.225389510424761 no 2641 0.224332678979661 3681 1296806
SGTC_1988 st071872 53.4 µM -0.757935897725129 0.225297047408038 no 2642 0.224244679338311 3764 16414116
SGTC_1346 1488-2224 62.4 µM -0.759810207877096 0.224707972258351 no 2643 0.22368402015679 3737 3722427
SGTC_1237 0330-0133 46.1 µM -0.759839608712289 0.224698738861863 no 2644 0.223675231889205 3715 X1237 YHR072W ERG7
SGTC_77 0828-0286 12.516 µM -0.760260984679785 0.224566428463536 no 2645 0.223549299054552 3738 745345
SGTC_3156 9099931 49.47 µM -0.76126933179156 0.224249990939316 no 2646 0.223248107221086 3805 18111053
SGTC_875 0709-0210 25.7 µM -0.761948745870788 0.224036921376614 no 2647 0.223045297526704 3763 6251364
SGTC_3291 9121177 71.43 µM -0.763348953532768 0.223598168259643 no 2648 0.222627657185989 3770 17015612
SGTC_2267 7931562 200 µM -0.764523966815629 0.223230356881291 no 2649 0.222277529916211 3687 934880
SGTC_342 k048-0088 23.3 µM -0.765228782957975 0.223009895452962 no 2650 0.222067661551056 3774 6820570
SGTC_2840 9008771 71.43 µM -0.76653705821765 0.22260100523003 no 2651 0.221678405223502 3752 2992978
SGTC_300 r073-0011 5.04 µM -0.769769176128379 0.221592668877766 no 2652 0.220718413576002 3790 2735780
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.771152403144954 0.221161937097334 no 2653 0.220308301291711 3845 688801
SGTC_615 k087-0205 167 µM -0.771602725273793 0.221021811877073 no 2654 0.220174879835912 3785 9642773
SGTC_960 1222-0186 7.7 µM -0.771848291194923 0.220945421370043 no 2655 0.220102143085482 3820 3126296
SGTC_381 3461-2219 42.7 µM -0.772987543794241 0.220591221082109 no 2656 0.21976487624212 3763 2883159
SGTC_2227 7312221 64.1025 µM -0.773090756569273 0.220559147706792 no 2657 0.21973433556909 3810 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3304 9125678 46.087 µM -0.774720596059681 0.220053029352455 no 2658 0.219252389006794 3771 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2168 5727979 200 µM -0.778158684393684 0.218987578672765 no 2659 0.218237735061467 3739 695210
SGTC_760 0568-0725 82.9 µM -0.778892138779633 0.218760668516981 no 2660 0.218021627563744 3840 3916171
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.778994468419637 0.218729021363912 no 2661 0.217991486620184 3751 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1935 st074532 41.6 µM -0.781228887506791 0.218038647079024 no 2662 0.217333943182149 3826 2829742
SGTC_1365 1672-3266 55.4 µM -0.782060464220438 0.21778203375388 no 2663 0.217089520065127 3794 6415873
SGTC_2317 5986382 200 µM -0.782519068430211 0.217640589261082 no 2664 0.216954791735987 3840 877883
SGTC_2622 2-methoxyxanthone 59.94 µM -0.78682709702752 0.216314480628141 no 2665 0.215691544415949 3827 71034 A hepatoprotective.
SGTC_977 1348-1378 135 µM -0.787426123209293 0.216130457953669 no 2666 0.215516229720758 3800 X977
SGTC_271 rotenone 740 µM -0.787702882926397 0.216045467152562 no 2667 0.215435259436626 3814 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1200 1643-0193 18.4 µM -0.791453332143724 0.214895642953196 no 2668 0.214339749362153 3796 5403974
SGTC_779 1360-0071 233 µM -0.791547240771479 0.214866897848534 no 2669 0.214312360200383 3900 7566
SGTC_307 1501-1223 22.3 µM -0.792920198591178 0.214446895334124 no 2670 0.213912159173418 3828 2830329
SGTC_2347 9049783 174.81 µM -0.793360701966451 0.214312241849104 no 2671 0.213783849882499 3835 6467988 YPL169C MEX67
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.793526253728549 0.214261648548435 no 2672 0.21373563975573 3851 4174840
SGTC_2956 9076196 2.52 µM -0.79376855864093 0.214187611696691 no 2673 0.213665089855452 3836 16423868
SGTC_1437 4092-1038 11.6 µM -0.795004717418519 0.213810132139357 no 2674 0.213305379021894 3830 3977136
SGTC_157 1348-1695 65.819 µM -0.796286863927195 0.213419019149228 no 2675 0.212932659478724 3797 5380510
SGTC_1419 3993-2473 62.6 µM -0.796755545097908 0.213276154228021 no 2676 0.212796508939514 3889 704026
SGTC_1905 st060207 84.5 µM -0.798976493550245 0.212599916139495 no 2677 0.212152021125771 3752 1948547
SGTC_1155 4088-0394 48.2 µM -0.800108894835301 0.212255603275162 no 2678 0.211823854043568 3810 2326248
SGTC_509 pifithrin 175 µM -0.800510541951715 0.212133558598349 no 2679 0.211707529098565 3867 4817 A p53 inhibitor.
SGTC_324 1315-0088 19.6 µM -0.800865211139122 0.212025822775508 no 2680 0.211604840980399 3788 6787421
SGTC_1784 st039334 36.3 µM -0.802749330061208 0.211454031535772 no 2681 0.211059817138859 3880 3496984
SGTC_143 4032-1194 15.74 µM -0.80349933401193 0.211226672311129 no 2682 0.210843090769692 3852 1806963
SGTC_2878 9043973 25.97 µM -0.803524739927284 0.211218973168402 no 2683 0.210835751585398 3928 6465167
SGTC_368 fentichlor 4.58 µM -0.805120812326096 0.210735620690067 no 2684 0.210374983427658 3876 7329 A pesticide.
SGTC_2250 alverine citrate 130 µM -0.805137684126885 0.21073051472401 no 2685 0.210370115888274 3752 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_127 0180-0333 59.125 µM -0.8053519157498 0.210665687446438 no 2686 0.210308315499704 3750 771601
SGTC_3152 9099253 49.47 µM -0.806045990185902 0.210455738343225 no 2687 0.210108165863117 3795 25236131
SGTC_2251 lansoprazole 556 µM -0.806750149281242 0.210242864310768 no 2688 0.2099052225175 3769 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2204 7233102 200 µM -0.806909952379367 0.210194571915796 no 2689 0.209859182244124 3747 2172480
SGTC_698 k064-0052 127 µM -0.806919097671364 0.21019180841146 no 2690 0.209856547607807 3890 5088751
SGTC_713 1488-1073 324 µM -0.807682689496284 0.209961143188798 no 2691 0.209636635605292 3791 3312542
SGTC_675 1309-0189 238 µM -0.809868992593889 0.209301529696864 no 2692 0.209007737322855 3877 4246530
SGTC_626 0214-0009 33 µM -0.810766079783968 0.209031229376995 no 2693 0.208750008679944 3905 3437874
SGTC_124 0136-0217 7.121 µM -0.811299208279462 0.208870690475276 no 2694 0.208596932307563 3920 3976905
SGTC_2621 lithochol-11-enic acid 100 µM -0.811363480886264 0.208851341223978 no 2695 0.208578482282847 3784 6708711
SGTC_1249 0481-0015 10.2 µM -0.811574658039473 0.208787773833699 no 2696 0.208517868772533 3799 4227577
SGTC_151 3013-0144 2.285 µM -0.812048276010299 0.208645249410562 no 2697 0.208381965478079 3817 906558 YHR107C CDC12
SGTC_1500 4488-1866 171 µM -0.813379753501591 0.208244879282951 no 2698 0.208000181896702 3950 2900003
SGTC_2384 9036245 200 µM -0.815555064207882 0.207591747898549 no 2699 0.207377329475161 3837 6462766
SGTC_1028 k015-0029 4.8 µM -0.815999214414843 0.207458541912134 no 2700 0.207250292510717 3826 4588309
SGTC_717 1532-0246 73.2 µM -0.816086304632064 0.207432428434928 no 2701 0.207225388144581 3859 9561992
SGTC_2475 5812728 15.03 µM -0.816586639813764 0.207282443594112 no 2702 0.20708234631778 3836 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1876 myriocin 605 nM -0.817963618263593 0.206869999756949 no 2703 0.206688980909946 3840 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2720 fluspirilene 36.88 µM -0.818625754877754 0.206671844259449 no 2704 0.206499984075837 3839 3396 An atypical antipsychotic.
SGTC_913 3487-1245 167 µM -0.820078057099118 0.206237612264335 no 2705 0.206085805186581 3832 4016153
SGTC_3187 9109394 49.47 µM -0.820675807638633 0.206059044692433 no 2706 0.205915477216326 3844 17098090
SGTC_99 0109-0120 622.8 µM -0.820765483123744 0.206032263613031 no 2707 0.205889931549386 3864 759414
SGTC_1900 st060200 72.8 µM -0.824432792637473 0.204938811527285 no 2708 0.204846844215907 3844 688945
SGTC_2776 terbinafine 19.92 µM -0.82470122090134 0.204858912176791 no 2709 0.204770619192795 3883 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_194 1486-1323 56.904 µM -0.825307900671414 0.204678398407282 no 2710 0.204598403746203 3899 5178754
SGTC_1748 st037455 53.6035 µM -0.825321788545708 0.204674267265329 no 2711 0.204594462467255 3892 580690
SGTC_1579 chlormadinone acetate 49.4 µM -0.825489273114267 0.204624450550194 no 2712 0.20454693510749 3909 45114258 A steroidal progestin.
SGTC_213 1246-0773 967 nM -0.828251800496046 0.203803803949388 no 2713 0.203763956650932 3867 6251622
SGTC_2786 7743617 45.45 µM -0.829249612030294 0.20350787330517 no 2714 0.203481588420089 3834 583674
SGTC_2587 piperic acid 92.2 µM -0.829432081523637 0.203453784292342 no 2715 0.203429977083712 3896 5370536
SGTC_26 0302-0163 425.158 µM -0.82965592683649 0.203387442055201 no 2716 0.203366673301092 3917 3100915
SGTC_646 4092-0839 27.3 µM -0.830145593297575 0.203242361984029 no 2717 0.203228235893107 3928 877796
SGTC_815 1582-0027 36.9 µM -0.83055242533262 0.203121871372808 no 2718 0.203113260039697 3943 3128206
SGTC_832 4083-0019 164 µM -0.830993785720345 0.202991202809675 no 2719 0.202988569967591 3947 1990758
SGTC_2726 cimetidine 79.27 µM -0.832169388607813 0.202643400413326 no 2720 0.202656669916824 3863 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_329 k048-0121 21.3 µM -0.832211877277582 0.202630836802504 no 2721 0.202644680452529 3891 6832902
SGTC_738 1315-0003 72.4 µM -0.833107575181669 0.202366093387109 no 2722 0.202392030854124 3896 6251474
SGTC_506 n9-isopropylolomoucine 153 µM -0.834067181164836 0.202082690163783 no 2723 0.202121563808677 3852 6610355
SGTC_2484 5809818 12.04 µM -0.834377409757443 0.201991120279474 no 2724 0.202034171483367 3880 2870548
SGTC_2124 5246320 200 µM -0.835077016698785 0.201784709127539 no 2725 0.201837173130953 3899 579342
SGTC_2647 atorvastatin 60.16 µM -0.836646141409559 0.201322216125274 no 2726 0.20139575066921 3874 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3177 9107506 49.47 µM -0.838212933189232 0.200861045350678 no 2727 0.200955562331105 3798 8897194
SGTC_29 0299-0004 12.984 µM -0.841467687756997 0.199905066737079 no 2728 0.200042989758994 3776 16871 A napthoquinone isolated from Swertia calycina.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.841807476154981 0.199805422892297 no 2729 0.199947863255577 3825 140250 A respiratory chain inhibitor.
SGTC_261 5-fluorouridine 15.376 µM -0.841906353651881 0.199776432417999 no 2730 0.199920186812721 3889 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1286 0929-0070 131 µM -0.844753962462655 0.198942611427847 no 2731 0.19912411181567 3996 1420408
SGTC_1931 st074438 57.1 µM -0.84547763756822 0.198731043615565 no 2732 0.198922106574129 3874 2787313
SGTC_2077 5212015 200 µM -0.84552789914461 0.198716354586799 no 2733 0.198908081245294 3777 780900
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.845778291232762 0.198643186840222 no 2734 0.198838219031405 3844 279621
SGTC_227 fluconazole 33.516 µM -0.84646564997768 0.198442415423438 no 2735 0.198646514245924 3895 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2508 celastrol 40.54 µM -0.846640097946581 0.198391480198917 no 2736 0.198597878337871 3837 122724 Celastrol is a natural product and antioxidant.
SGTC_721 1187-1332 279 µM -0.853630214799583 0.196357006628155 no 2737 0.196654955836522 3845 25730
SGTC_409 arachidonic acid 100 µM -0.853924885004359 0.196271521576314 no 2738 0.196573305152693 3909 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_50 0929-0078 56.389 µM -0.854233197106046 0.196182103111838 no 2739 0.196487896403201 3790 1377751
SGTC_2438 5259590 200 µM -0.854351137139887 0.196147903992304 no 2740 0.196455230552186 3936 1201127
SGTC_2094 5332512 191.667 µM -0.85573801960779 0.195746020399891 no 2741 0.196071352661846 3956 755774
SGTC_2733 amorolfine 100 µM -0.857010952035961 0.195377596889252 no 2742 0.19571941595998 3966 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2253 7938677 135.83 µM -0.857064357830396 0.195362148918494 no 2743 0.195704658865544 4002 2301972
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.85734750404491 0.195280259444558 no 2744 0.195626431159255 3910 442882
SGTC_2962 9082311 13.18 µM -0.858583361074795 0.194923078173368 no 2745 0.195285210600529 3921 16459453
SGTC_804 1595-0054 20.9 µM -0.859350961602333 0.194701430208707 no 2746 0.195073457998934 3861 761523 Stimulates phospholipase C.
SGTC_3068 9116768 49.47 µM -0.860113600490066 0.194481366857392 no 2747 0.194863212413334 3868 41904888
SGTC_78 0336-0123 156.75 µM -0.860283550984914 0.19443234740881 no 2748 0.194816378955452 3757 6765896
SGTC_1103 duloxetine 36.1 µM -0.862144966496868 0.193895944917765 no 2749 0.194303874740652 4016 60835 A selective serotonin reuptake inhibitor.
SGTC_3079 9117512 49.47 µM -0.863473717566363 0.193513592136851 no 2750 0.193938531899998 3943 7185044
SGTC_2202 7226349 200 µM -0.863655009363379 0.193461460464706 no 2751 0.193888717822095 3874 844334
SGTC_549 1661-1316 519 µM -0.86674025796768 0.192575590602498 no 2752 0.193042171084858 3917 2857282
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.869589412692502 0.191759716517903 no 2753 0.192262412835963 3964 279621
SGTC_3344 9148862 3.898 µM -0.871637912871467 0.191174425085431 no 2754 0.191702970458046 3974 4905352
SGTC_736 0958-0254 92.6 µM -0.874203999115926 0.1904427977261 no 2755 0.191003584282085 4026 6812352
SGTC_1720 st037298 9.481 µM -0.874941726726212 0.190232779812842 no 2756 0.190802806792093 3962 597396
SGTC_2294 7971431 200 µM -0.876544219754984 0.189777069064591 no 2757 0.190367124015101 3937 5741572
SGTC_3239 9133757 49.47 µM -0.878169903434988 0.189315450072228 no 2758 0.189925761102931 3943 17036923
SGTC_68 0986-0284 82.829 µM -0.87853488441402 0.189211907441019 no 2759 0.189826757599119 4032 423278 YIL048W NEO1
SGTC_499 genistein 192 µM -0.878581263520244 0.189198752500184 no 2760 0.189814179232755 3958 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1006 4099-6547 255 µM -0.880344828649702 0.1886989538965 no 2761 0.189336267290811 3980 3146833
SGTC_250 brefeldin a 552.239 µM -0.881031755524343 0.188504497605071 no 2762 0.189150316258211 3811 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_389 tpck 16.7 µM -0.88236643045727 0.188127029278953 no 2763 0.188789341566348 3959 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3241 9133421 49.47 µM -0.883157130630776 0.187903626286759 no 2764 0.188575690077871 3948 17018221
SGTC_491 tetrandrine 80.3 µM -0.886471448971221 0.18696898833683 no 2765 0.187681766349637 3964 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2877 9040724 71.43 µM -0.886542167354682 0.186949077141055 no 2766 0.187662721058891 3923 6463895
SGTC_7 0192-1582 4.227 µM -0.886754907809809 0.186889186667916 no 2767 0.18760543475595 3991 252616
SGTC_1243 0416-0003 5.65 µM -0.887289842265313 0.186738644941023 no 2768 0.187461436477592 3955 2141977
SGTC_2064 5220758 200 µM -0.887572547726579 0.186659116046577 no 2769 0.187385362977006 4018 788518
SGTC_1356 1502-0781 85.8 µM -0.888005443559817 0.186537377202264 no 2770 0.1872689115857 3911 567702
SGTC_1906 st060206 94.7 µM -0.890685583165252 0.185784764125968 no 2771 0.186548935608192 3979 5133468
SGTC_897 1000-0139 31.4 µM -0.891198243887237 0.18564101816844 no 2772 0.186411413184718 3915 6151020
SGTC_315 k915-0449 187 µM -0.891215780176205 0.185636102354507 no 2773 0.186406710145759 3984 20970215 YNL149C PGA2
SGTC_1467 k284-1082 293 µM -0.891926900706367 0.185436827418372 no 2774 0.186216057403032 3906 3334705
SGTC_921 1561-0023 372 µM -0.892268949005361 0.185341023676926 no 2775 0.186124396671108 3923 24050882
SGTC_476 mead acid 10 µM -0.893367196608145 0.185033625114457 no 2776 0.185830281772928 3959 5312531 An omega 9 fatty acid.
SGTC_3130 9127414 49.47 µM -0.894955646886704 0.184589579987328 no 2777 0.1854053990121 3952 1494646
SGTC_288 1315-0019 35.1 µM -0.896048893363978 0.184284352488851 no 2778 0.185113325283072 4039 6811474
SGTC_158 k038-0087 26.446 µM -0.896424410208186 0.184179583068836 no 2779 0.185013067497382 3886 X158
SGTC_2225 6654152 15.4 µM -0.898719527463119 0.183540050010464 no 2780 0.184401036508182 3843 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3174 9107204 49.47 µM -0.899470737424041 0.183331026799836 no 2781 0.18420098785127 4018 3938802
SGTC_178 4092-0806 87.505 µM -0.900887282886721 0.182937278860535 no 2782 0.183824126730519 3885 2169044
SGTC_1516 st013856 110 µM -0.901020231459625 0.182900351118278 no 2783 0.183788781445131 4025 5281404 A mutagen and neurotoxin.
SGTC_601 0986-0029 62.9 µM -0.901888415133397 0.182659319166303 no 2784 0.18355807299092 3924 24747981
SGTC_1212 0520-0165 585 µM -0.902291140238679 0.182547578839619 no 2785 0.183451115369946 4110 5403258
SGTC_347 4534-1311 26.2 µM -0.90238556443112 0.18252138603151 no 2786 0.183426043373801 3979 2862016
SGTC_688 0527-0193 473 µM -0.902730569988214 0.182425703140077 no 2787 0.183334453890135 3993 4007154
SGTC_2653 dihydrofissinolide 100 µM -0.903994245135724 0.182075506609164 no 2788 0.182999226468187 4024 6857746
SGTC_3100 9120536 49.47 µM -0.906259782081168 0.181448721702106 no 2789 0.182399183633035 3812 16421196
SGTC_3322 9139058 2.11 µM -0.908855160516702 0.180732344831533 no 2790 0.181713292612446 4074 4908926 YPR165W RHO1
SGTC_390 dec-rvkr-cmk 16.7 µM -0.914721343964538 0.179119704101436 no 2791 0.180168968171516 4022 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3346 9158254 43.5805 µM -0.914910156131943 0.179067949584252 no 2792 0.180119398943618 4004 17639500
SGTC_3006 9075424 71.4286 µM -0.915004086556335 0.179042206211387 no 2793 0.180094742394686 3929 7465181
SGTC_1019 4262-0212 3.4 µM -0.915639395327097 0.178868149215141 no 2794 0.179928030748038 4011 4677213
SGTC_3026 9090633 49.47 µM -0.916248132842438 0.178701471956245 no 2795 0.179768382628517 3985 25236842
SGTC_667 1498-1044 59 µM -0.916852870043152 0.178535986879203 no 2796 0.179609871779634 4000 6739982
SGTC_996 3970-0799 1.8 µM -0.91773106540516 0.17829584246539 no 2797 0.179379839818312 4018 6615648 YGL040C HEM2
SGTC_235 0330-0087 5 mM -0.91868554949541 0.178035067690971 no 2798 0.179130035174465 4008 46494818 YHR062C RPP1
SGTC_1518 st038567 90.8 µM -0.919724361257196 0.177751527172807 no 2799 0.17885840937359 3958 77966
SGTC_3313 9133968 57.047 µM -0.919976882760851 0.17768264526085 no 2800 0.178792419896515 3973 1494643
SGTC_2035 5154463 94.595 µM -0.920081805997049 0.177654029629537 no 2801 0.178765005632336 4020 2769623
SGTC_2730 imipramine 71.33 µM -0.920193470402512 0.177623578678884 no 2802 0.178735832947418 3975 3696 A tricyclic antidepressant.
SGTC_2813 7971799 71.43 µM -0.920925838031901 0.177423943234911 no 2803 0.1785445738502 4043 2234054
SGTC_1817 st052116 64.4 µM -0.921274318818788 0.177329000920892 no 2804 0.178453612755294 4014 4361398
SGTC_778 3456-2434 196 µM -0.92154645808198 0.177254879887697 no 2805 0.178382598769074 3991 5539063
SGTC_373 0844-0104 25.9 µM -0.921659304498998 0.177224150286354 no 2806 0.178353157032349 4025 5375804
SGTC_417 st075190 100 µM -0.922212940195457 0.177073436569693 no 2807 0.17820875731907 4006 222757
SGTC_1303 1160-0052 261 µM -0.92222412027537 0.177070393901931 no 2808 0.178205842080748 3959 3562476
SGTC_1113 artemisinin 1.17947 µM -0.922314273642694 0.177045859797401 no 2809 0.178182335426694 4029 2240 An anti-malaria and mitochondrial poison.
SGTC_2376 9072922 81.32 µM -0.922872050438696 0.176894115613881 no 2810 0.178036943757346 4039 17087968
SGTC_2328 6201408 200 µM -0.92301484129124 0.176855282323345 no 2811 0.177999735520604 4014 2890418
SGTC_1563 conessine 56.1 µM -0.923281449133108 0.176782790283098 no 2812 0.177930276354695 4070 441082 An anti-amoebic, histamine inhibitor.
SGTC_1188 1403-0014 4.57 µM -0.92479570317421 0.176371413229526 no 2813 0.17753609305755 4005 9614867
SGTC_92 0063-0024 660.874 µM -0.924848114054081 0.17635718563027 no 2814 0.177522459586357 4070 3594437
SGTC_678 1218-2179 85.9 µM -0.926988357207672 0.175776809807316 no 2815 0.17696628965763 3975 6820081 YOR116C RPO31
SGTC_1078 idebenone 36.1 µM -0.927150722797698 0.17573283009799 no 2816 0.176924141835153 4054 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1525 8-methoxypsoralen 92.5 µM -0.929180754764952 0.175183547120815 no 2817 0.176397709690605 4080 4114 Related to psoralen; DNA damaging agent.
SGTC_2299 7976368 114.88 µM -0.929454481905991 0.175109565846474 no 2818 0.176326802090459 4052 2979718
SGTC_3209 9113616 49.47 µM -0.930993252288902 0.174694045462764 no 2819 0.17592852731572 4061 16649353
SGTC_2735 sertaconazole 140 nM -0.931887016592564 0.17445298630675 no 2820 0.175697459047948 4120 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3312 9133330 71.43 µM -0.932687474849702 0.174237272374719 no 2821 0.175490676842014 4061 17617324
SGTC_1737 st035557 69.7 µM -0.933939699603888 0.173900152928791 no 2822 0.175167499446689 3890 5716916
SGTC_2217 6934799 96.0675 µM -0.935215556187864 0.173557098312656 no 2823 0.174838611584086 3955 675606
SGTC_3045 9092950 49.47 µM -0.935438085884065 0.173497308264231 no 2824 0.174781288472025 3965 44120432
SGTC_2380 9035439 200 µM -0.93688221702936 0.173109612753557 no 2825 0.17440957375229 4135 6462575
SGTC_2848 9016370 25.97 µM -0.938099224408269 0.172783320333598 no 2826 0.174096710190785 3988 7894410
SGTC_2106 5357045 167.29 µM -0.940793883513698 0.172062249935777 no 2827 0.173405247980134 4051 668842
SGTC_1431 4049-0260 9.09 µM -0.941588447128215 0.171849997947999 no 2828 0.173201693413359 4004 3854841
SGTC_1634 st006576 41 µM -0.943039388803621 0.171462839157769 no 2829 0.172830378044292 4026 3915356
SGTC_1647 st011722 22.4 µM -0.947727738357694 0.170215648093695 no 2830 0.171634037990035 3998 2854783
SGTC_2333 9017922 200 µM -0.948987097478021 0.169881627218984 no 2831 0.171313587175443 4092 3163164
SGTC_886 0866-0150 153 µM -0.949725149510686 0.16968606851014 no 2832 0.171125963680738 4093 271463
SGTC_892 0929-0076 29 µM -0.95119603658319 0.169296764235565 no 2833 0.170752435020051 4013 5751038
SGTC_1552 6-methylflavone 10.6 µM -0.951820595584859 0.169131633801888 no 2834 0.170593987532305 3929 689013
SGTC_32 0928-0142 34.1 µM -0.951980530131689 0.169089364506443 no 2835 0.170553428083275 4013 2244242
SGTC_1294 1000-1494 117 µM -0.953110583857767 0.168790894570161 no 2836 0.170267022079271 4025 712797 YDL207W GLE1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.953932663160738 0.168573979728541 no 2837 0.170058864249897 4044 115019
SGTC_2480 5767542 37.17 µM -0.954095206187329 0.168531112156794 no 2838 0.170017726223153 3993 2867358
SGTC_401 neomycin 50 µM -0.954173390766425 0.1685104949865 no 2839 0.169997940754401 4007 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3206 9114350 49.47 µM -0.955148007428826 0.168253625968036 no 2840 0.169751427154245 3950 17087243
SGTC_2703 st077852 53.4 µM -0.956675724485327 0.167851489485308 no 2841 0.169365477284153 4084 6281836
SGTC_1732 st034308 51.822 µM -0.958029134303812 0.167495752723688 no 2842 0.169024033824075 3911 830119
SGTC_2760 etidronate 98.04 µM -0.958969429019352 0.167248887299557 no 2843 0.16878707310606 4007 3305 A chelator and antioxidant.
SGTC_635 k038-0028 24.7 µM -0.959308908910045 0.167159817737184 no 2844 0.168701574317513 4043 4035102
SGTC_2676 harmalol 100 µM -0.960327710501227 0.166892697729597 no 2845 0.168445153945866 3989 5459187 A monoamine oxidase inhibitor
SGTC_2430 5571206 200 µM -0.960624586064459 0.166814911638473 no 2846 0.168370481039822 4066 1731771
SGTC_833 3852-0053 558 µM -0.960674457259224 0.166801846891939 no 2847 0.168357939061397 4115 3123681
SGTC_2727 riluzole 51.77 µM -0.963234298438357 0.166132132467191 no 2848 0.167714978215179 4060 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2330 7979373 200 µM -0.963269915736663 0.166122826417415 no 2849 0.16770604330958 3990 1863007
SGTC_2495 cafestol 54.53 µM -0.964348184986053 0.16584125680581 no 2850 0.167435695312177 4066 16667697 An anti-infammatory.
SGTC_3315 9136395 68.55 µM -0.967688132073515 0.164971051790301 no 2851 0.16660007349561 4047 16876844
SGTC_2103 5378138 10 µM -0.970084768710919 0.16434844655309 no 2852 0.166002120225283 4113 244142
SGTC_3227 9130768 49.47 µM -0.97266699717074 0.163679334938721 no 2853 0.165359416436568 4098 17720899
SGTC_1857 st056007 79.3 µM -0.973510722330887 0.163461091249354 no 2854 0.165149766891708 4049 619834
SGTC_607 4491-0986 66.8 µM -0.973676910942565 0.163418126062517 no 2855 0.165108492495337 4070 698981 YDR232W HEM1
SGTC_627 1391-0720 175 µM -0.97483622116353 0.163118610573572 no 2856 0.164820753441648 4033 997839
SGTC_303 1348-1668 34.2 µM -0.974844488044411 0.163116476051988 no 2857 0.164818702781252 4068 5380509
SGTC_2224 6650123 117.647 µM -0.976350443343627 0.162727938909633 no 2858 0.164445415251165 4026 2908370
SGTC_106 0092-0003 11.579 µM -0.976615142167771 0.162659708746506 no 2859 0.164379859901989 3954 1072148
SGTC_2952 9073731 13.78 µM -0.976926278343843 0.162579532444273 no 2860 0.164302825535684 4138 16457353
SGTC_641 4092-0595 30 µM -0.977483623036673 0.162435975263074 no 2861 0.164164890806682 4097 786260
SGTC_3090 9117696 49.47 µM -0.977942955784386 0.162317725384275 no 2862 0.164051269083155 4028 7923821
SGTC_1539 benzyladenosine 56 µM -0.982537319827641 0.161138044000707 no 2863 0.162917603328561 4059 92208 A nucleotide analog.
SGTC_2002 4023503 131 µM -0.982660651595874 0.161106453757341 no 2864 0.16288724141103 4068 4736863 YCR052W RSC6
SGTC_2054 5233173 129 µM -0.984372844425335 0.160668309584882 no 2865 0.162466112474059 4101 6889
SGTC_216 k038-0035 28.382 µM -0.985212553396029 0.160453715668726 no 2866 0.162259837830017 4007 4444231 YPR107C YTH1
SGTC_2394 5221648 200 µM -0.987004116695804 0.1599964945366 no 2867 0.161820310232387 4131 788586
SGTC_1511 0906-3109 28.5 µM -0.987214198963454 0.159942935746609 no 2868 0.161768821220333 4095 2882180
SGTC_2954 9074818 52.69 µM -0.991895719707121 0.158752462047543 no 2869 0.160624198659556 4110 16648742
SGTC_2076 5212012 200 µM -0.993346923358983 0.158384614870459 no 2870 0.160270458893973 4021 604802
SGTC_2242 6630449 61.2675 µM -0.993548773402746 0.158333494798749 no 2871 0.16022129707834 4142 691249 YDR170C SEC7
SGTC_882 0843-0131 351 µM -0.993586427922511 0.158323959701014 no 2872 0.160212127180256 4075 5425421
SGTC_1952 st077036 64.1 µM -0.994239324409172 0.158158689335152 no 2873 0.160053183701273 4102 2937007
SGTC_497 capsazepine 133 µM -0.995512499019439 0.157836731226348 no 2874 0.159743534149521 4046 2733484 A calcium channel blocker.
SGTC_1307 1187-1599 12.2 µM -0.997851017419803 0.157246493020687 no 2875 0.159175803528599 4061 1538471
SGTC_3255 9139072 49.47 µM -0.999967867804521 0.156713456472506 no 2876 0.158663029106992 4102 17646060
SGTC_2597 laccaic acid a 100 µM -1.00029068077474 0.156632274718806 no 2877 0.158584927916485 4108 5491415 A textile dye.
SGTC_2612 dictamnine 15.46 µM -1.00235309790223 0.156114266815503 no 2878 0.158086543030959 4056 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_709 3807-1509 243 µM -1.00249543287035 0.156078558880171 no 2879 0.158052185629307 4144 1886677 YPL242C IQG1
SGTC_180 1486-1293 102.781 µM -1.00876973805744 0.154509856064935 no 2880 0.15654253872001 3978 4140536
SGTC_3198 9112019 49.47 µM -1.0129419385151 0.153472510942493 no 2881 0.155543947422806 4146 45595555
SGTC_346 4513-0042 7.16 µM -1.01345979235721 0.153344078139977 no 2882 0.155420295998272 4088 2827372
SGTC_3221 9128209 49.47 µM -1.01363345089837 0.153301025075543 no 2883 0.155378844913421 4137 16460723
SGTC_3235 9132602 49.47 µM -1.01811112077154 0.152193696009732 no 2884 0.154312575489729 4121 4912240
SGTC_146 3448-8650 53.125 µM -1.01944251224423 0.151865469385017 no 2885 0.153996466119179 4097 2891488 YIL048W NEO1
SGTC_493 zm226600 134 µM -1.01978700352999 0.151780618932657 no 2886 0.153914744128078 4156 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1202 1988-0068 29.6 µM -1.01997065539965 0.151735397154571 no 2887 0.153871189019236 4089 2850480
SGTC_2551 apiole 73.87 µM -1.02045986416142 0.151614979839616 no 2888 0.153755207461538 3984 10659 A possible DNA adduct former.
SGTC_3041 9091929 49.47 µM -1.02224001440064 0.151177337285218 no 2889 0.153333658189692 4118 25236887
SGTC_1228 0124-0032 52.5 µM -1.02265539790914 0.15107533802506 no 2890 0.153235403397843 4177 X1228
SGTC_2926 9010726 65.15 µM -1.02475221509363 0.150561154412464 no 2891 0.152740059343 4154 2994293
SGTC_3253 9135987 49.47 µM -1.02709874581344 0.149987119468604 no 2892 0.152186984595293 4130 4182430
SGTC_215 1287-0124 461.5 µM -1.02727002004921 0.149945277645556 no 2893 0.15214666758069 4141 5560863
SGTC_1498 4478-3555 97.6 µM -1.0276147860581 0.149861075867403 no 2894 0.152065533064325 4092 3437919
SGTC_3021 9087658 49.47 µM -1.0292138628336 0.149470947720095 no 2895 0.151689594706516 4111 25237042
SGTC_2783 7738165 71.43 µM -1.02930668423575 0.149448322837162 no 2896 0.151667791645985 4119 17201110
SGTC_1761 st044296 37 µM -1.03023394491976 0.149222431861579 no 2897 0.15145009931131 4102 1826700
SGTC_1369 1866-0067 208 µM -1.03049810544746 0.149158121180763 no 2898 0.15138812057448 4140 3531355
SGTC_1395 3486-0190 4.35 µM -1.03054319378116 0.149147146138944 no 2899 0.151377543397139 4106 6748079
SGTC_3201 9113999 49.47 µM -1.03178184886846 0.148845853539628 no 2900 0.151087162104634 4150 16649224
SGTC_1612 st002233 45.4 µM -1.03179665021778 0.148842255694766 no 2901 0.151083694426357 4113 1035021
SGTC_987 1497-1013 404 µM -1.03330873983984 0.14847501002407 no 2902 0.150729719256889 4111 1676435
SGTC_201 4262-0159 12.803 µM -1.03440752682598 0.148208524845833 no 2903 0.150472843569611 4159 1341029
SGTC_669 0108-0021 26.2 µM -1.03529831428369 0.147992720123282 no 2904 0.150264808422687 4031 17201
SGTC_2997 9067075 71.4286 µM -1.03890302890737 0.147121580145871 no 2905 0.149424918791691 4141 27209819
SGTC_1218 1348-1416 30.7 µM -1.04086722761694 0.146648348416575 no 2906 0.148968586798599 4078 6787668
SGTC_2930 9013230 14.89 µM -1.04234733557088 0.146292423619226 no 2907 0.148625336842771 4140 2995857
SGTC_1677 st019204 53.9 µM -1.04286466688564 0.146168156750041 no 2908 0.148505487995701 4160 3945625
SGTC_1136 pergolide 1.05886 µM -1.04315059179009 0.14609950586982 no 2909 0.148439276227525 4097 47811 A dopamine receptor agonist.
SGTC_1456 k015-0012 13 µM -1.04779903255557 0.144986448641646 no 2910 0.147365604169394 4158 2989616
SGTC_1877 wortmannin 25 µM -1.04822131010278 0.144885618956358 no 2911 0.147268327264563 4138 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1777 st045864 34.765 µM -1.04875071339169 0.144759276942456 no 2912 0.147146433423363 4125 4691462
SGTC_1646 st011709 75.6 µM -1.04901624218708 0.144695936484076 no 2913 0.14708532153105 4085 5757843
SGTC_908 3448-7491 47.7 µM -1.05137088207896 0.144135066654453 no 2914 0.146544141870099 4156 1203031
SGTC_2280 7785178 200 µM -1.05308851248766 0.143726856877893 no 2915 0.146150213629348 4134 2954328
SGTC_472 calcifediol 10 µM -1.0542483955058 0.143451642293538 no 2916 0.145884604098788 4200 5283731 A vitamin D metabolite.
SGTC_1163 k060-0048 49.9 µM -1.0545355093901 0.14338357149158 no 2917 0.145818906050479 4134 6809982
SGTC_1706 st031321 9.9705 µM -1.05898446465066 0.142331571918189 no 2918 0.144803427455311 4162 6103185
SGTC_2048 5246248 200 µM -1.0606175309389 0.141946730706379 no 2919 0.144431876101572 4179 677046
SGTC_129 0088-0017 176.636 µM -1.06221832564288 0.141570178822954 no 2920 0.144068291160239 4007 182446
SGTC_1170 0310-0127 64.8 µM -1.0670081798807 0.14044751552343 no 2921 0.142984071104586 4185 774975
SGTC_2725 haloperidol 53.21 µM -1.06793277852683 0.140231502694229 no 2922 0.142775417682694 4089 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3120 9124077 49.47 µM -1.06821406924053 0.140165829888717 no 2923 0.142711979892057 4282 18774327 YGL155W CDC43
SGTC_174 3553-0389 74.3 µM -1.07169290592025 0.139355354528434 no 2924 0.141928994110836 4244 738071
SGTC_839 0122-0028 230 µM -1.0735702654657 0.13891930737735 no 2925 0.141507665195142 4157 759448
SGTC_427 1354-0053 47.3 µM -1.07441629892257 0.138723106394116 no 2926 0.141318070313816 4235 6813657
SGTC_3285 9112818 20.8695 µM -1.07447720897862 0.138708988219883 no 2927 0.141304427105503 4138 17017947 YPR165W RHO1
SGTC_2163 5671233 125 µM -1.07601776024376 0.138352233482047 no 2928 0.140959656769924 4140 701023
SGTC_2833 9001315 45.46 µM -1.07670682140197 0.138192866044693 no 2929 0.140805631972731 4134 2989378
SGTC_3115 9123671 49.47 µM -1.07758684393275 0.137989514745648 no 2930 0.140609087971181 4291 3286988
SGTC_3043 9092303 49.47 µM -1.07847737617038 0.137783942780196 no 2931 0.140410386379342 4166 25236084
SGTC_172 1112-0046 2.638 µM -1.0812531673013 0.137144515752846 no 2932 0.139792256809546 4162 2802135 YIL048W NEO1
SGTC_121 0557-0495 61.343 µM -1.0821559994563 0.136936978305817 no 2933 0.139591608086822 4259 3104427
SGTC_1051 3253-3903 78 µM -1.08218901773897 0.136929392338568 no 2934 0.139584273696965 4158 5509239
SGTC_110 0850-0284 111.64 µM -1.08440913046996 0.136419979112216 no 2935 0.139091718606209 3978 3906265
SGTC_2166 5933061 31.504 µM -1.0866816158777 0.13589989298824 no 2936 0.138588770733789 4324 2877375
SGTC_2768 sulfasalazine 50.2 µM -1.08758603062009 0.1356932847654 no 2937 0.138388950218677 4136 5384001 An antioxidant and salicylic acid derivative.
SGTC_2141 5621638 7.665 µM -1.08865319422954 0.135449774368811 no 2938 0.138153424785165 4200 2856238
SGTC_997 3996-0078 137 µM -1.09166577570176 0.134763966068176 no 2939 0.137490016703334 4236 735687
SGTC_2482 5981709 142.65 µM -1.09300739415239 0.134459317355493 no 2940 0.137195276636949 4137 877755
SGTC_25 0118-0223 35.662 µM -1.09419303864386 0.134190480356352 no 2941 0.136935161974817 4180 5333628
SGTC_1707 st032323 6.317 µM -1.09475464674726 0.134063268403959 no 2942 0.136812070318034 4058 3132057 YMR211W DML1
SGTC_1008 4106-0037 6 µM -1.09538517306901 0.133920544288079 no 2943 0.136673963515358 4179 2905394
SGTC_1979 st071809 45.3 µM -1.10052984957549 0.132759912105754 no 2944 0.135550665699695 4275 4976333
SGTC_1945 st075991 56.6 µM -1.10097312244769 0.132660235481012 no 2945 0.135454177559981 4197 1084980
SGTC_3197 9113331 49.47 µM -1.10099551278841 0.132655202041554 no 2946 0.135449305056429 4216 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2544 sphondin 68.51 µM -1.10129150650507 0.132588673817535 no 2947 0.135384903282401 4185 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_533 1222-0222 6.71 µM -1.10253924067975 0.132308482924631 no 2948 0.135113654270905 4224 3982874
SGTC_1970 st070122 35.8 µM -1.10362149577616 0.132065782719723 no 2949 0.13487868129218 4219 102928
SGTC_378 3970-0959 8.33 µM -1.10431127433351 0.13191125729466 no 2950 0.134729066910345 4226 6615653
SGTC_223 busulfan 5 mM -1.10491958266751 0.131775086502337 no 2951 0.134597218121164 4202 2478 A DNA alkylator.
SGTC_3018 9082602 49.47 µM -1.10742675323676 0.131214876149741 no 2952 0.134054732207405 4141 17332089
SGTC_2271 7849410 118.62 µM -1.11037254799032 0.130558762571928 no 2953 0.133419261333798 4147 972430
SGTC_570 0987-0065 62.6 µM -1.11216010208298 0.13016173045384 no 2954 0.133034659496146 3989 3104428
SGTC_2055 5235184 200 µM -1.11458851687782 0.129623696994035 no 2955 0.132513396698411 4254 2836034
SGTC_2670 beta-carotene 100 µM -1.11473354821918 0.129591613036025 no 2956 0.132482310102561 4150 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3306 9127676 59.7925 µM -1.11511963214728 0.129506230033081 no 2957 0.13239957982951 4196 41905287
SGTC_3136 9095672 49.47 µM -1.11588504144102 0.129337073938054 no 2958 0.132235672786483 3936 17217380
SGTC_677 0929-0063 136 µM -1.11761223054052 0.12895592649976 no 2959 0.131866321455474 4190 1539583
SGTC_411 enrofloxacin 100 µM -1.11910965072852 0.128626114319449 no 2960 0.131546681595259 4292 71188 A bacterial gyrase inhibitor.
SGTC_1367 1812-0510 76.9 µM -1.11927626304334 0.128589453578499 no 2961 0.131511149560567 4243 1142582 YDR527W RBA50
SGTC_883 0850-0245 24.6 µM -1.11955086005895 0.128529048119417 no 2962 0.131452602977342 4279 6823229 YPR165W RHO1
SGTC_812 4251-0442 148 µM -1.1218543356291 0.128023108361378 no 2963 0.130962189559254 4250 5723007
SGTC_2900 5328528 85.29 µM -1.12353954035158 0.12765384424265 no 2964 0.13060420866293 4227 795359
SGTC_676 falcarinol 140 µM -1.12368432155151 0.127622154182518 no 2965 0.130573484997512 4255 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2287 7945887 168.79 µM -1.12856524020139 0.126557005879262 no 2966 0.129540640471047 4240 1245853
SGTC_1219 1469-0211 33.1 µM -1.13134805498668 0.125952499773209 no 2967 0.12895431282837 4259 6822282
SGTC_1828 st055811 49 µM -1.13136914805241 0.125947925464385 no 2968 0.128949875645563 4220 5877589
SGTC_1975 st070967 30.8 µM -1.13248508530841 0.125706084961859 no 2969 0.12871527565364 4217 261391
SGTC_662 k832-1615 104 µM -1.13306957809902 0.125579545881583 no 2970 0.128592517808549 4256 5878478
SGTC_768 0384-0033 77.3 µM -1.13342594587696 0.125502438089048 no 2971 0.128517711703124 4177 3965305 YMR134W ERG29
SGTC_1968 st069590 43.6 µM -1.1352976288981 0.125098001940569 no 2972 0.12812531768129 4203 6384066
SGTC_1919 st067113 52.3 µM -1.1360433063732 0.124937128633571 no 2973 0.127969220161985 4252 1268243
SGTC_2138 5575593 77.673 µM -1.13990252031662 0.124106847198819 no 2974 0.127163457468485 4232 762213
SGTC_1971 st069429 63.5 µM -1.14014212289864 0.124055426051991 no 2975 0.127113547654165 4215 1246522 YGL099W LSG1
SGTC_2856 9022925 19.48 µM -1.14035191363903 0.124010415071467 no 2976 0.127069858914488 4279 4944862
SGTC_2295 7971645 200 µM -1.15276369634678 0.12136776022583 no 2977 0.12450369453227 4295 2978226 YKL099C UTP11
SGTC_1959 st077091 55.8 µM -1.15326490098539 0.121261884384276 no 2978 0.124400835959811 4235 821356 YKL052C ASK1
SGTC_3102 9121669 49.47 µM -1.15650193191713 0.120579649460382 no 2979 0.123737954905202 4277 41905072
SGTC_1102 cgs 12066b 26.1 µM -1.15710523402234 0.120452797206016 no 2980 0.123614684262901 4257 6438352 A 5-HT1B full agonist.
SGTC_460 trequinsin 123 µM -1.15838188057486 0.120184675312858 no 2981 0.123354115066304 4316 5537 A vasodilator.
SGTC_3258 9138477 49.47 µM -1.15840232888288 0.12018038417441 no 2982 0.123349944609919 4266 4970355
SGTC_3161 9100388 49.47 µM -1.16442838599571 0.118920498707658 no 2983 0.122125224793156 4331 25236368
SGTC_358 0075-0058 9.45 µM -1.16915482105108 0.117938877200149 no 2984 0.121170629962465 4130 1069125
SGTC_1375 2910-0797 186 µM -1.16946219180726 0.117875239235389 no 2985 0.121108732760857 4264 742508
SGTC_275 trichlorophene 5.69 µM -1.17016891856782 0.117729010864432 no 2986 0.120966499076167 4293 62616
SGTC_2417 cerulenin 830 nM -1.17158130324811 0.117437160043146 no 2987 0.120682599079322 4274 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1387 3342-1166 1.8 µM -1.1721893509118 0.117311672827592 no 2988 0.120560521451529 4221 3418228
SGTC_2419 paclitaxel 166.5 µM -1.17392208051949 0.11695459783082 no 2989 0.120213118652892 4181 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_621 3584-0052 32.1 µM -1.18104498805313 0.115494826652969 no 2990 0.118792425979908 4287 2273927
SGTC_848 0368-0089 85.6 µM -1.18148481410305 0.115405114836747 no 2991 0.118705091320907 4269 762535
SGTC_1355 1499-0035 1.68 µM -1.18218250738665 0.115262907154848 no 2992 0.11856664597153 4263 1548538
SGTC_586 0957-0265 8.15 µM -1.18353470188061 0.114987650188523 no 2993 0.118298650961603 4135 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1832 st054113 55 µM -1.18570221857155 0.114547399535408 no 2994 0.117869959049739 4285 1251267
SGTC_2889 9059656 51.95 µM -1.18982846486608 0.113712624194738 no 2995 0.117056909633842 4346 3949838
SGTC_2583 asiatic acid 100 µM -1.19554636375438 0.112563025325113 no 2996 0.115936816520329 4319 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1014 4130-3005 69.3 µM -1.19911472582429 0.111849816799 no 2997 0.115241669442713 4294 743608
SGTC_22 0964-0034 14.468 µM -1.20043897108252 0.111585963859323 no 2998 0.114984450609017 4290 138402
SGTC_2555 cholic acid 100 µM -1.20132751364651 0.111409173562079 no 2999 0.114812090877968 4225 6708657 Influences liver metabolism.
SGTC_2541 muurolladie-3-one 83.07 µM -1.20248465339543 0.111179242051969 no 3000 0.114587904246698 4248 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_896 0964-0007 44.5 µM -1.20371149012362 0.110935832590594 no 3001 0.114350554831831 4254 6756758
SGTC_2012 4023501 200 µM -1.2049913523081 0.110682309750663 no 3002 0.114103320151735 4302 3477460
SGTC_1760 st045453 10.4495 µM -1.20581204944385 0.110519959744817 no 3003 0.113944984209281 4331 3323419 YIL048W NEO1
SGTC_2108 5365811 200 µM -1.20604428129146 0.110474050728715 no 3004 0.113900208476503 4304 780283
SGTC_1744 st037937 38.9 µM -1.20871581901297 0.109946907805492 no 3005 0.113386021060564 4344 1016152
SGTC_1288 0973-0013 65.5 µM -1.20914893403986 0.109861616659339 no 3006 0.113302816174848 4318 4315430
SGTC_170 4197-0004 226 µM -1.20917137023093 0.109857199707987 no 3007 0.113298507188642 4296 218692
SGTC_1373 2887-0003 58.5 µM -1.21462118669033 0.108788081739659 no 3008 0.112255302211856 4253 776948
SGTC_1183 1254-0324 198 µM -1.2162122075193 0.10847737871765 no 3009 0.111952047294463 4370 5799357
SGTC_1289 0976-0073 69.1 µM -1.22201764773966 0.107349077199719 no 3010 0.110850476679511 4374 3391136
SGTC_2081 5214970 32.255 µM -1.22476476349669 0.10681812730289 no 3011 0.110331932398261 4261 2063512
SGTC_2486 5283202 22.39 µM -1.22479433376442 0.106812422424111 no 3012 0.110326360206985 4339 1377751
SGTC_2766 oltipraz 83.91 µM -1.2250036374628 0.106772048546456 no 3013 0.110286924999638 4280 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1425 4048-4433 7.33 µM -1.2253514909265 0.106704973314249 no 3014 0.110221407796783 4360 23734946
SGTC_1632 st005650 90 µM -1.22602615145044 0.106574967843747 no 3015 0.110094417006039 4339 2759605
SGTC_3083 9117465 49.47 µM -1.22692301239 0.106402321964373 no 3016 0.109925764173737 4292 16420915
SGTC_1458 k015-0034 6.33 µM -1.22739437559354 0.106311665472486 no 3017 0.109837199667462 4329 3598957
SGTC_3196 9111891 49.47 µM -1.22963411254742 0.105881662863737 no 3018 0.109417074932182 4297 18891510
SGTC_293 4049-0273 38.5 µM -1.22980696230427 0.105848530109346 no 3019 0.10938470021038 4180 1380311
SGTC_2909 7941780 10.49 µM -1.23160888779711 0.105503573700435 no 3020 0.109047609646965 4287 1243215
SGTC_2529 gangaleoidin 93.61 µM -1.23378964480833 0.105087183002949 no 3021 0.108640649534231 4322 4565183
SGTC_1075 aripiprazole 15.2 µM -1.23860414406636 0.104172123555213 no 3022 0.107746066327881 4376 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2824 7998404 51.95 µM -1.23947534873889 0.104007158605987 no 3023 0.10758475621616 4271 837851
SGTC_1342 1486-1464 234 µM -1.24881534989236 0.102250494392111 no 3024 0.105866309159571 4359 3253938
SGTC_634 1611-4317 11.2 µM -1.25036614639218 0.101960922637819 no 3025 0.105582912666437 4352 2843522
SGTC_1833 st055984 71 µM -1.25353478886423 0.101371115697457 no 3026 0.105005573299998 4333 676288
SGTC_397 arbidol 50 µM -1.25409961814237 0.101266240658143 no 3027 0.104902899578545 4366 131410 A RNA synthesis inhibitor.
SGTC_3103 9120822 49.47 µM -1.25700444405322 0.100728133832473 no 3028 0.104376013182446 4332 17141819
SGTC_2427 5545055 42.75 µM -1.25713272069836 0.100704419292008 no 3029 0.104352790256486 4260 5372858
SGTC_1117 retinoic acid 1.10837 µM -1.25889758662928 0.100378561332203 no 3030 0.10403366282791 4372 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1030 k029-0042 36.7 µM -1.2591377893387 0.100334270798069 no 3031 0.103990283548754 4312 6080581
SGTC_2451 5856223 45.7 µM -1.2596235363367 0.100244748392593 no 3032 0.103902600415846 4306 2179896
SGTC_1655 st012546 55.1 µM -1.26015636124002 0.100146616671916 no 3033 0.103806480840702 4325 720985 YLR208W SEC13
SGTC_2071 5230951 39.92 µM -1.26267603619103 0.0996835116045325 no 3034 0.10335281477265 4378 1799272
SGTC_2648 atorvastatin 78.68 µM -1.26277462032683 0.0996654241387009 no 3035 0.103335094059428 4335 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1745 st081495 74 µM -1.2646366138725 0.099324250004805 no 3036 0.103000810838278 4193 13842402 YBL026W LSM2
SGTC_187 1488-2104 32.728 µM -1.26621466062623 0.0990357727208664 no 3037 0.102718120062 4333 2852859
SGTC_1491 4138-0063 26.5 µM -1.26645071897969 0.098992672456941 no 3038 0.102675881176147 4331 23883227
SGTC_1317 1273-0028 910 nM -1.27055129474968 0.0982461647952532 no 3039 0.101944161733176 4359 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1005 4092-0690 4.4 µM -1.27275967386819 0.0978458429070962 no 3040 0.101551667497205 4360 1529343
SGTC_1788 fluconazole 20 µM -1.27311955139507 0.0977807198983961 no 3041 0.10148781104615 4360 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2197 6588183 93.1375 µM -1.27509521151235 0.0974237727516538 no 3042 0.101137772032262 4336 884136
SGTC_1932 st074806 40.9 µM -1.27580171513355 0.0972963593812001 no 3043 0.101012810566459 4398 17251235
SGTC_1683 st010134 710 nM -1.27735306995208 0.0970170116013492 no 3044 0.100738812646503 4330 3818134
SGTC_1649 st011737 51.3 µM -1.2816492524728 0.0962464844866595 no 3045 0.0999828571801614 4368 1761035
SGTC_2988 9073640 71.4286 µM -1.28172563032077 0.0962328268125699 no 3046 0.0999694553292603 4396 9102229
SGTC_98 0074-0023 107.663 µM -1.28368946716388 0.0958821480426186 no 3047 0.0996253156379328 4364 3563821
SGTC_181 1447-1644 8.07 µM -1.28624434334247 0.0954273364300364 no 3048 0.0991788998805848 4330 534600
SGTC_2608 thymoquinone 42.66 µM -1.28787771009631 0.0951374025774206 no 3049 0.098894267870497 4317 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_420 mitomycin C 81.9 mM -1.28832297733388 0.0950584772223979 no 3050 0.0988167789581011 4337 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3268 9137683 49.47 µM -1.29250780937293 0.0943190548501229 no 3051 0.0980906716170734 4441 1953228
SGTC_2282 7944268 200 µM -1.2999889610449 0.0930077869322709 no 3052 0.0968023763293766 4363 2970414
SGTC_3042 9091578 49.47 µM -1.30116091669632 0.0928035978061497 no 3053 0.0966016900178359 4379 25236497
SGTC_2875 9039966 71.43 µM -1.30304682214136 0.0924757138344306 no 3054 0.0962793884500324 4366 6463691
SGTC_1032 k061-1018 98.7 µM -1.30474940360141 0.0921804395028543 no 3055 0.0959890964563526 4416 4005393
SGTC_591 4299-0174 154 µM -1.30587761685751 0.0919851612073559 no 3056 0.0957970897509981 4400 5509088
SGTC_1098 clofazimine 15.1 µM -1.30663679468108 0.0918539304319046 no 3057 0.0956680470227097 4423 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2595 hexamethylquercetagetin 100 µM -1.3094110963742 0.0913755464660695 no 3058 0.0951975673633408 4376 386331
SGTC_1859 st055998 20 µM -1.31158497932088 0.0910019876149754 no 3059 0.0948301019215393 4322 676301
SGTC_2367 9070478 135.38 µM -1.31259360613661 0.090829050969654 no 3060 0.0946599626343983 4313 572802
SGTC_1917 st066507 28.5 µM -1.31722865039793 0.0900374721184436 no 3061 0.0938809965488407 4326 3156428
SGTC_1126 isoteolin 1.0172 µM -1.32316414931563 0.0890312995715909 no 3062 0.0928903977006718 4325 133323
SGTC_1984 st072354 53.1 µM -1.32434553539812 0.0888320361743234 no 3063 0.0926941570445345 4251 5762938
SGTC_122 0236-0016 402.397 µM -1.32550647406005 0.0886365453077424 no 3064 0.0925016117931133 4378 6808838
SGTC_3062 9077494 49.47 µM -1.32842870008074 0.0881458893355436 no 3065 0.092018261715432 4344 16459633
SGTC_1606 st000094 49.2 µM -1.33197629230898 0.0875529558797872 no 3066 0.0914339895350044 4409 1242210
SGTC_1422 4031-0024 15.5 µM -1.33200034867633 0.0875489453588982 no 3067 0.091430036969985 4335 782427
SGTC_1794 st048918 76.9 µM -1.33254838416712 0.0874576175834413 no 3068 0.0913400266768597 4342 672303
SGTC_1264 0783-0040 158 µM -1.33888687263087 0.086406497457935 no 3069 0.0903037519226763 4310 2855798
SGTC_1559 coumarin 343 70.1 µM -1.33915383652646 0.0863624346844032 no 3070 0.0902602986077846 4432 108770 A hepatotoxic, DNA x-linker.
SGTC_2126 5251174 33.877 µM -1.33924542475306 0.0863473217880618 no 3071 0.090245394507312 4386 790722
SGTC_2264 7948757 110.76 µM -1.33930859506256 0.086336899260844 no 3072 0.0902351159036876 4351 2971411
SGTC_2368 9071271 200 µM -1.34136057092003 0.0859988532976805 no 3073 0.0899017063416749 4371 27209959
SGTC_34 0469-0683 81.75 µM -1.34536863493983 0.0853414161936584 no 3074 0.089253109455631 4367 3690923
SGTC_306 1672-3436 11.6 µM -1.34559379155147 0.0853045960717273 no 3075 0.0892167774942502 4420 6797378
SGTC_1977 st070720 65.3 µM -1.3477899574525 0.084946078475575 no 3076 0.0888629744187107 4419 682188
SGTC_840 0245-0196 390 µM -1.34989740576521 0.0846031068993504 no 3077 0.0885244469816528 4481 3827528
SGTC_349 k015-0014 24 µM -1.35065138726549 0.0844806546125883 no 3078 0.088403565709064 4419 2196908
SGTC_1937 st074714 47.2 µM -1.35623114529835 0.0835785897686713 no 3079 0.0875128176670505 4344 17250970
SGTC_2642 cholecalciferol 100 µM -1.35634603175581 0.0835600927194191 no 3080 0.087494547922036 4397 9821465 A vitamin D precursor, similar to steriods.
SGTC_547 1120-0019 610 nM -1.35742146328026 0.0833870943025587 no 3081 0.0873236661316276 4363 3676939
SGTC_162 k030-0015 37.8 µM -1.35779038852657 0.0833278095038122 no 3082 0.0872651028102511 4458 1809920 YMR134W ERG29
SGTC_1642 st009582 77.7 µM -1.36542739102727 0.0821076800325932 no 3083 0.0860593798656342 4389 6739311
SGTC_2029 5175081 200 µM -1.37277723241513 0.0809461852360927 no 3084 0.0849108053772571 4369 1380876
SGTC_454 lyso-paf C-16 6.67 µM -1.37358779118001 0.0808188558576281 no 3085 0.0847848446425951 4433 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_200 k038-0079 37.545 µM -1.37490509764986 0.0806122449687339 no 3086 0.0845804343394741 4411 3436683
SGTC_12 0849-0099 9.267 µM -1.37534380235245 0.0805435256376879 no 3087 0.0845124413655675 4351 6071388
SGTC_3109 9122853 49.47 µM -1.37622055024271 0.0804063231960246 no 3088 0.0843766808145367 4449 1234709
SGTC_1568 digitonin 820 nM -1.37653105145708 0.0803577751698435 no 3089 0.0843286403287062 4390 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_842 0271-0008 11.1 µM -1.37766527152839 0.0801806238377654 no 3090 0.0841533291824988 4463 1221709
SGTC_2947 9072639 7.68 µM -1.38025679138829 0.0797769680244878 no 3091 0.0837537968249636 4388 16488146
SGTC_2397 5161689 200 µM -1.38270864373147 0.0793964837032653 no 3092 0.0833771102327918 4466 2259942
SGTC_703 3875-0075 71.8 µM -1.38784729656142 0.0786035133212563 no 3093 0.0825917746037102 4470 2850814
SGTC_2244 6635614 200 µM -1.38911196022148 0.0784092805082007 no 3094 0.0823993537010849 4370 836499
SGTC_701 4424-0219 185 µM -1.39327714281945 0.077772145348559 no 3095 0.0817679999043294 4447 2911779
SGTC_740 k014-0057 261 µM -1.39725578874036 0.0771672211218883 no 3096 0.0811683328117686 4427 4012779
SGTC_1190 1486-1332 13 µM -1.39727127725213 0.0771648732121624 no 3097 0.0811660048634031 4433 4150046
SGTC_526 4469-0568 170 µM -1.39792219623816 0.0770662492094879 no 3098 0.0810682162294159 4386 2901964
SGTC_2790 5423970 71.43 µM -1.397940541276 0.0770634710493144 no 3099 0.081065461512922 4449 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1762 st045503 25.4615 µM -1.3980791155908 0.0770424879072453 no 3100 0.0810446552825693 4484 4645554
SGTC_562 3772-2733 112 µM -1.39865739308416 0.0769549710794661 no 3101 0.0809578733509856 4419 2876874 YIL048W NEO1
SGTC_3273 9137859 49.47 µM -1.40077708849178 0.0766348213138381 no 3102 0.0806403710228599 4514 2377234
SGTC_2716 st080858 38.6235 µM -1.40113357649216 0.0765810785323501 no 3103 0.0805870663429863 4415 5296050
SGTC_2336 9001819 198.65 µM -1.40266430939319 0.076350636810556 no 3104 0.0803584824800803 4468 2989602
SGTC_3080 9117754 49.47 µM -1.40728277693885 0.0756585544071671 no 3105 0.0796717771806208 4424 9550191
SGTC_653 0203-0016 55.2 µM -1.40759943541419 0.0756112784375957 no 3106 0.0796248573663459 4499 295302
SGTC_1470 k295-0292 231 µM -1.41003655583689 0.0752481780373904 no 3107 0.0792644445434096 4507 5045612
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.41126633379734 0.0750654619022488 no 3108 0.0790830486875868 4403 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2120 5538279 151.968 µM -1.41168015853104 0.0750040534057708 no 3109 0.0790220790712523 4413 2058197
SGTC_786 4544-0069 423 µM -1.41203772992501 0.0749510233472895 no 3110 0.0789694260469537 4424 748821 YLR208W SEC13
SGTC_2880 9042983 58.44 µM -1.41269455904909 0.07485368603313 no 3111 0.0788727760357893 4388 6464714
SGTC_1749 st037932 54.2 µM -1.41458912983442 0.0745734646298808 no 3112 0.078594498880845 4462 594497
SGTC_535 2293-4129 48.2 µM -1.41575780388063 0.0744010085889064 no 3113 0.0784232139136146 4448 396118 YIL048W NEO1
SGTC_2179 6298986 200 µM -1.41761645535426 0.0741273630951242 no 3114 0.0781513866267878 4406 738374
SGTC_2408 sulbentine 18.36 µM -1.42096889414952 0.0736357351612768 no 3115 0.0776629012910572 4325 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_298 1391-0729 10 µM -1.42105058270099 0.073623786897455 no 3116 0.0776510274115053 4387 3237558
SGTC_1727 st034309 9.9045 µM -1.42446734302811 0.0731253572184373 no 3117 0.0771556160057349 4471 870305
SGTC_1954 st077032 68.9 µM -1.42734902129382 0.0727069948259613 no 3118 0.0767396585908845 4394 698907
SGTC_410 α-linolenic acid 100 µM -1.43281530562059 0.0719184382399728 no 3119 0.0759553130584925 4485 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_714 4296-0578 26.1 µM -1.43297201148295 0.0718959292110178 no 3120 0.0759329180094493 4498 1589775
SGTC_192 3455-0609 60.9 µM -1.43363375007663 0.0718009374990222 no 3121 0.0758384034853971 4521 3769639
SGTC_1496 4469-0713 57.4 µM -1.43489882637771 0.071619605402978 no 3122 0.0756579651006205 4439 746691
SGTC_1327 1436-0082 2.18 µM -1.43786002708321 0.0711965300190325 no 3123 0.0752368867024432 4475 15992205
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.44016274562593 0.0708688622257945 no 3124 0.0749106802412776 4406 97141
SGTC_1439 4092-1168 46 µM -1.44045462468483 0.0708274118471595 no 3125 0.0748694093908102 4460 2886240
SGTC_515 4092-1064 102 µM -1.44245894797263 0.070543276489748 no 3126 0.0745864722985124 4432 717353
SGTC_1650 st011916 45.8 µM -1.44338848714047 0.0704118016197501 no 3127 0.0744555327148653 4411 242528
SGTC_2462 5162487 171.77 µM -1.44937090781432 0.0695701461428002 no 3128 0.0736170143017706 4427 2259986
SGTC_2490 carminic acid 95.39 µM -1.45190578485649 0.069215864345949 no 3129 0.0732639019203225 4442 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1965 Pectolinarigenin 58.4 µM -1.45200506406708 0.0692020171333935 no 3130 0.073250098583254 4444 5320438 An anti-inflammatory.
SGTC_2259 7964009 200 µM -1.452904163487 0.0690767102013703 no 3131 0.0731251824073681 4479 313134
SGTC_1063 disulfiram 1.84 µM -1.45522709733114 0.068753773834703 no 3132 0.072803200761892 4486 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1245 0418-0076 17.2 µM -1.45564732867277 0.0686954774414838 no 3133 0.0727450686560439 4488 6790114
SGTC_834 0312-0008 75.7 µM -1.45693295100844 0.0685173667712704 no 3134 0.0725674446045821 4493 6385573 YIL048W NEO1
SGTC_455 paf C-16 10 µM -1.45697071658936 0.0685121401024889 no 3135 0.0725622318664346 4435 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1149 3909-7961 23.3 µM -1.45784627786098 0.0683910506578962 no 3136 0.0724414595763093 4522 735261
SGTC_3264 9137442 49.47 µM -1.46178141590868 0.0678488620183418 no 3137 0.0719005591510733 4446 17015726
SGTC_651 3253-0966 34.4 µM -1.46255669792264 0.067742435114874 no 3138 0.0717943596753673 4488 781462
SGTC_1302 1159-0335 255 µM -1.46281360805986 0.0677071962148276 no 3139 0.0717591942310578 4484 649284
SGTC_1177 0983-0204 23.6 µM -1.46299064833158 0.0676829208518375 no 3140 0.0717349689349615 4492 766818
SGTC_1547 harmine 94.2 µM -1.4666638298802 0.0671807780105938 no 3141 0.0712337634517339 4392 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1468 k284-1086 134 µM -1.47244408607783 0.0663964265548479 no 3142 0.070450497771619 4487 15996457
SGTC_2665 lovastatin 100 µM -1.47386551421022 0.0662046364314833 no 3143 0.0702589022666163 4511 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1197 1601-0112 267 µM -1.47393183237359 0.0661956987577863 no 3144 0.0702499729788491 4448 7350313
SGTC_2993 9054257 71.4286 µM -1.47706346113963 0.0657747134589904 no 3145 0.0698293134376731 4405 6470217 YGL055W OLE1
SGTC_1854 st056233 32.9 µM -1.48302500013673 0.0649790419958798 no 3146 0.0690338843395124 4405 5393174
SGTC_1477 0139-0234 16 µM -1.48841199606166 0.0642664978025068 no 3147 0.0683211374490168 4497 620880
SGTC_2992 9074591 71.4286 µM -1.49024266173845 0.0640257409053573 no 3148 0.0680802213760037 4426 17741321
SGTC_286 k060-0067 22.9 µM -1.49077118343097 0.0639563638869203 no 3149 0.0680107899292732 4517 5985051
SGTC_2761 levamisole 97.89 µM -1.49299643428162 0.0636649047628997 no 3150 0.0677190601383668 4496 26879 An alkaline phosphatase inhibitor.
SGTC_2186 6124449 200 µM -1.49532185043867 0.0633614314780486 no 3151 0.0674152325893631 4504 3834182 YLR033W RSC58
SGTC_1465 k213-0056 144 µM -1.49785775711721 0.0630317734553866 no 3152 0.0670851054685711 4405 24048857 YMR208W ERG12
SGTC_1398 3558-0053 112 µM -1.50113368079302 0.0626078955059738 no 3153 0.0666604944641007 4465 4532369
SGTC_2812 7970281 58.44 µM -1.50414786219915 0.0622198506848703 no 3154 0.0662716494417472 4514 2233435
SGTC_55 0767-0285 6.563 µM -1.51675556094048 0.0606170413969392 no 3155 0.0646642053353231 4423 3116166
SGTC_2332 7982454 138.89 µM -1.51810580951177 0.0604473175276422 no 3156 0.0644938634334385 4404 2981748
SGTC_1195 1502-0147 41.1 µM -1.5311474163795 0.0588270918261825 no 3157 0.0628664816206995 4517 817940
SGTC_559 1550-0661 158 µM -1.5312699625515 0.0588120305308783 no 3158 0.0628513429973548 4547 5830875
SGTC_138 0850-0259 40.9225 µM -1.53430853278359 0.0584395479670765 no 3159 0.0624768837746392 4463 6813004
SGTC_847 0342-0274 5.54 µM -1.53892881523342 0.0578767246435093 no 3160 0.0619108377891214 4502 18097
SGTC_819 1013-0258 27.7 µM -1.54216237246302 0.0574853673073005 no 3161 0.0615170706089336 4513 5753198
SGTC_846 0335-0850 148 µM -1.54258864575313 0.0574339311344378 no 3162 0.061465307327858 4506 6819598
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.54317987804319 0.0573626501641607 no 3163 0.0613935690440044 4433 5355888
SGTC_2892 9047358 58.44 µM -1.54332054836411 0.0573457007282686 no 3164 0.0613765101815499 4521 6466771
SGTC_2749 bexarotene 57.39 µM -1.54591480579799 0.0570338233195071 no 3165 0.0610625721630075 4515 82146 An retinoic acid receptor inhibitor.
SGTC_3294 9122953 26.2835 µM -1.54777138910165 0.0568114488260817 no 3166 0.0608386736176561 4507 16459826
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.55510460803908 0.055939772604642 no 3167 0.0599605788429014 4451 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1887 st057648 70.8 µM -1.55566291833473 0.0558738426366776 no 3168 0.0598941343402228 4513 688672
SGTC_2449 5812982 45.77 µM -1.55795511726451 0.0556038028296391 no 3169 0.0596219440313327 4460 776185
SGTC_513 4245-1575 41.7 µM -1.56112924769463 0.0552315664130598 no 3170 0.0592466292269768 4354 719745
SGTC_2021 4019055 173 µM -1.56255548664537 0.0550649507813842 no 3171 0.0590785926034353 4317 44827708 YER133W GLC7
SGTC_1583 clindamycin 39.6 µM -1.56769977105988 0.0544672840938908 no 3172 0.0584756075720473 4504 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_302 1094-0063 18.9 µM -1.56821935202627 0.0544072051833899 no 3173 0.0584149747998205 4526 5440289
SGTC_894 0960-0238 55.9 µM -1.57108110793795 0.0540772405845619 no 3174 0.05808190512073 4528 6741907 YDL195W SEC31
SGTC_1227 3909-8010 46.6 µM -1.57558646480092 0.0535609783335369 no 3175 0.057560568731187 4520 15982272
SGTC_516 3992-2719 87.3 µM -1.57656733933548 0.0534491006046383 no 3176 0.0574475564064077 4433 5350887 YDR037W KRS1
SGTC_2496 diffractaic acid 79.83 µM -1.57833370777517 0.0532480971620741 no 3177 0.0572444829897546 4524 94870 An apoptosis inducer which activates caspases.
SGTC_2132 5317594 122.667 µM -1.58045085865193 0.0530079665495782 no 3178 0.0570018261431298 4476 794577
SGTC_1666 st014829 29 µM -1.58156576625364 0.0528818576029085 no 3179 0.0568743671469252 4562 3858230
SGTC_1891 st059073 26.2 µM -1.585014435668 0.0524932793004185 no 3180 0.0564815272270858 4603 688754
SGTC_585 0kpi-0023 191 µM -1.58773783288951 0.0521880253996521 no 3181 0.0561728171192401 4477 64601
SGTC_1172 0370-0043 85 µM -1.59372338050229 0.0515220855887362 no 3182 0.0554990025648597 4563 376585
SGTC_193 1273-0060 1.558 µM -1.59551050167852 0.0513245694936483 no 3183 0.0552990617493251 4399 2847393 YHR072W ERG7
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.59631049013351 0.0512363486069588 no 3184 0.0552097445876995 4567 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2067 5224629 34.075 µM -1.59817981889693 0.051030673651624 no 3185 0.0550014818704921 4513 2835000
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.60057006392696 0.0507686422371062 no 3186 0.0547360885646263 4574 77254
SGTC_2945 9067681 61.76 µM -1.60378480785765 0.0504179156142896 no 3187 0.0543807472210528 4571 16456930
SGTC_1050 3232-1156 69.3 µM -1.60430103436996 0.0503617759433315 no 3188 0.0543238566120066 4497 700529
SGTC_3037 9091026 49.47 µM -1.60562410233156 0.0502181196362383 no 3189 0.0541782632286222 4423 25236398 YIL048W NEO1
SGTC_537 1334-0398 209 µM -1.60874383990031 0.0498806772616399 no 3190 0.0538361827199108 4568 5846986
SGTC_1282 0886-0010 32.4 µM -1.60951439384017 0.0497976104204003 no 3191 0.0537519550989519 4561 2836211 YNL267W PIK1
SGTC_2364 9055074 200 µM -1.61384219316002 0.0493331157483349 no 3192 0.053280829979933 4546 6470630
SGTC_1728 st035614 33.7865 µM -1.61986161167432 0.0486928216264346 no 3193 0.0526310038673766 4504 15945546
SGTC_1350 1495-0454 146 µM -1.6218521946946 0.0484825480827925 no 3194 0.0524174997676468 4584 1069057
SGTC_1512 0259-0544 12.2 µM -1.62984895425799 0.0476451251481618 no 3195 0.0515667121883532 4526 18476
SGTC_2971 9092186 9.93 µM -1.63369775877092 0.0472462275649386 no 3196 0.0511611646046354 4531 25236400
SGTC_2123 5259487 200 µM -1.6342576546783 0.0471884225330897 no 3197 0.0511023805403653 4560 2173474
SGTC_877 0771-0151 33.1 µM -1.6354506319017 0.04706544571273 no 3198 0.050977307878778 4563 6166523
SGTC_560 2332-1943 155 µM -1.63710844760634 0.0468949782948948 no 3199 0.0508039059015345 4558 21177716
SGTC_2222 6885208 172.143 µM -1.64080089486306 0.0465170764565217 no 3200 0.0504193762327643 4585 609514
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.64854781143333 0.0457321655561684 no 3201 0.0496201539985533 4570 23847180
SGTC_3017 9080681 49.47 µM -1.65994385204767 0.0445969140446626 no 3202 0.0484628742485471 4593 16451914
SGTC_2305 7443522 69.23 µM -1.66358847064263 0.0442386728054997 no 3203 0.0480973487444851 4475 5415886
SGTC_2393 9031399 185.94 µM -1.66419186096712 0.0441795880511868 no 3204 0.048037047029554 4549 1526623 YDL150W RPC53
SGTC_257 daunorubicin 18.5 µM -1.66836132621606 0.0437730452618262 no 3205 0.0476220103174092 4599 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1953 st076800 12.1 µM -1.67858262655286 0.0427891803818987 no 3206 0.0466167074186537 4543 297591
SGTC_1457 k015-0032 57.3 µM -1.67921775309793 0.0427286400766774 no 3207 0.0465548066352063 4579 4302660
SGTC_1848 st056003 16.4 µM -1.68130013709816 0.0425306326204674 no 3208 0.0463523156424683 4582 146492
SGTC_1186 1319-0216 26 µM -1.68844823731514 0.0418565806962183 no 3209 0.0456626087149448 4619 4565136
SGTC_2882 9058044 58.44 µM -1.68951313878533 0.041756906942412 no 3210 0.0455605680683799 4590 18076804
SGTC_1572 epiandrosterone 68.9 µM -1.69548383014613 0.0412016108959578 no 3211 0.0449918375695486 4545 441302 A steroid.
SGTC_2005 4024620 188 µM -1.69976262386613 0.0408073618709509 no 3212 0.0445877922698316 4550 236743
SGTC_1638 st008370 60.6 µM -1.70235152221898 0.0405703101600806 no 3213 0.0443447459284196 4545 24207134
SGTC_2635 hydroquinidine 100 µM -1.70962536685878 0.0399102600239016 no 3214 0.0436675858761952 4529 442912 An experimental heart treatment.
SGTC_2189 6047310 154.431 µM -1.71130747432318 0.0397588698769642 no 3215 0.0435121836543878 4607 711535
SGTC_2436 5633522 8.09 µM -1.72345719969848 0.0386792058797006 no 3216 0.0424029393487928 4578 5724242
SGTC_1844 rapamycin 4 nM -1.72654467396762 0.0384086830257029 no 3217 0.0421247347576257 4441 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1806 st050005 60.3 µM -1.73175000478371 0.0379560882242878 no 3218 0.0416590415851229 4643 5194765
SGTC_1696 st025591 34.7925 µM -1.73374630808313 0.0377836714662106 no 3219 0.041481553033057 4605 2787147
SGTC_1316 1272-0050 65.9 µM -1.73743496351317 0.0374667715875272 no 3220 0.0411552121565292 4614 7340392
SGTC_2359 9039622 200 µM -1.75807762010403 0.0357331554511221 no 3221 0.0393671515701123 4562 6463596
SGTC_2093 5331342 194.4 µM -1.76213219335949 0.0354004890625439 no 3222 0.0390234825702579 4634 33839
SGTC_132 0417-1715 25.805 µM -1.76232157510458 0.0353850131135964 no 3223 0.0390074903164582 4581 6769098
SGTC_2478 5763493 32.33 µM -1.76839969948894 0.0348912585186139 no 3224 0.0384970533923728 4563 1365576 YLR208W SEC13
SGTC_1657 st012939 43.4 µM -1.7722455148003 0.0345817765147947 no 3225 0.0381769056387606 4610 24207257
SGTC_2386 9075165 157.42 µM -1.77409900129576 0.0344334292195731 no 3226 0.0380233879829542 4599 16452277
SGTC_2471 5466956 24.79 µM -1.77532771304445 0.0343353754605439 no 3227 0.0379218960423238 4624 724419
SGTC_2974 9094440 9.66 µM -1.77751106793653 0.0341617053949013 no 3228 0.0377420957255836 4591 25236134
SGTC_27 0485-0001 32.618 µM -1.77874658206416 0.0340637495762227 no 3229 0.037640659223726 4628 2054479
SGTC_221 trifluoperazine 10.304 µM -1.77902232821372 0.0340419190261436 no 3230 0.0376180506949222 4607 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1278 0874-0585 172 µM -1.78076651145109 0.0339041001540989 no 3231 0.0374753011964811 4648 766306
SGTC_1653 st012112 65 µM -1.78948481735585 0.0332220759975389 no 3232 0.0367683852337595 4596 720429
SGTC_1596 piperlongumine 63 µM -1.79924090982273 0.0324723071316064 no 3233 0.0359902903587237 4627 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2780 5215298 71.43 µM -1.80014407671191 0.0324036091577694 no 3234 0.0359189457085942 4626 2834131
SGTC_1842 st055362 61.2 µM -1.80817936321201 0.0317976817140098 no 3235 0.0352892946999121 4609 676032
SGTC_1548 st061468 90.8 µM -1.81265622887195 0.0314641691040743 no 3236 0.0349424297462096 4676 390799
SGTC_2097 5376186 200 µM -1.81761376096238 0.0310982279873684 no 3237 0.0345615934457235 4616 742755
SGTC_1495 4469-0029 237 µM -1.8220857005568 0.0307711584357981 no 3238 0.0342209915346456 4646 793680
SGTC_292 k038-0015 474 µM -1.82512898891577 0.0305502103795385 no 3239 0.033990783270118 4634 46368540
SGTC_1045 1348-1485 165 µM -1.82935464304576 0.0302456010283773 no 3240 0.0336732488471276 4613 6810614
SGTC_2050 5263056 171 µM -1.83255616400779 0.0300164968139456 no 3241 0.0334343010984885 4611 763468 YGL055W OLE1
SGTC_932 2857-0803 154 µM -1.83308318786876 0.0299789207273391 no 3242 0.0333951004481729 4623 674898
SGTC_2925 9010536 32.5 µM -1.83334080257228 0.029960567347587 no 3243 0.0333759525407806 4577 2994177
SGTC_986 1493-0483 84 µM -1.83540558071786 0.0298138016689388 no 3244 0.0332228087256839 4607 40079
SGTC_2276 7947513 42.08 µM -1.83766910932844 0.0296535945002008 no 3245 0.0330555892006588 4562 2105100
SGTC_2855 9016525 58.44 µM -1.83988732908268 0.0294972879439742 no 3246 0.0328923903294466 4588 43811474
SGTC_3085 9117376 49.47 µM -1.84314551928208 0.0292689406211541 no 3247 0.0326538834103351 4675 16480349
SGTC_218 alverine citrate 93.75 µM -1.84648807860367 0.0290362079821516 no 3248 0.0324106843877082 4680 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2465 5809242 33.21 µM -1.85157658740643 0.0286848638692835 no 3249 0.0320433238002554 4693 2731748
SGTC_2379 9035213 200 µM -1.85426754950814 0.0285004958723743 no 3250 0.0318504461266649 4638 646551
SGTC_2279 7948423 32.93 µM -1.86253197653309 0.0279404218573747 no 3251 0.0312640712582219 4580 1247112
SGTC_1059 3448-6867 171 µM -1.8651605554812 0.0277642182286641 no 3252 0.0310794513091707 4611 3934407
SGTC_931 2812-0076 566 µM -1.88113374317188 0.0267132754390653 no 3253 0.0299768639510266 4594 3450959
SGTC_1897 st060201 15 µM -1.89411625534859 0.0258837675205983 no 3254 0.0291047902747773 4645 611878
SGTC_2571 chrysanthemic acid 100 µM -1.89466813091354 0.0258489888208989 no 3255 0.0290681911910987 4633 2743 An insecticide.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.89592025600144 0.0257702260142269 no 3256 0.0289852950051365 4635 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2607 solasodine 47.35 µM -1.9001818287953 0.025503662607549 no 3257 0.0287046310321794 4594 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2564 betulinic acid 100 µM -1.90450864103907 0.0252353846704422 no 3258 0.0284219861826751 4624 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1510 1123-0200 71.5 µM -1.90898218043644 0.0249604995339519 no 3259 0.0281321952272557 4654 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.9124861507981 0.024746948710424 no 3260 0.0279069336504138 4679 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2095 5432005 200 µM -1.92112775911873 0.0242268254017166 no 3261 0.027357801387295 4681 783734
SGTC_445 e6 berbamine 66 µM -1.92872724582591 0.0237770424204844 no 3262 0.0268823659865509 4667 6610268 A calcium/calmodulin antagonist.
SGTC_1524 corynanthine 62.1 µM -1.933179470568 0.0235168094868223 no 3263 0.026607046421726 4698 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2194 5927483 104.545 µM -1.93617121588419 0.0233432910168482 no 3264 0.02642336729445 4689 760979
SGTC_156 3474-0145 5.642 µM -1.93862542901344 0.0232017545576666 no 3265 0.0262734824194899 4599 2265471
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.94802779242772 0.0226661806617903 no 3266 0.0257058188705412 4680 2346 DNA damaging agent; causes G2/M arrest.
SGTC_119 0121-0043 24.815 µM -1.95270188385327 0.0224038383883236 no 3267 0.0254274651743084 4659 1092378
SGTC_2472 5377652 49.4 µM -1.9542212023651 0.0223191171845289 no 3268 0.0253375314589236 4694 1610903
SGTC_1513 0337-0559 19 µM -1.95864824338656 0.0220737933679166 no 3269 0.0250769977998546 4639 775073
SGTC_1837 st055472 66.5 µM -1.96513478342313 0.0217184559678063 no 3270 0.0246993198486315 4692 676091
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.96785997886706 0.0215706158722054 no 3271 0.0245420753663629 4683 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1617 st002906 78 µM -1.98039933689519 0.020901277713051 no 3272 0.0238293372082451 4677 5150859
SGTC_2821 7996764 71.43 µM -1.98078919975245 0.0208807522399885 no 3273 0.0238074592493546 4632 2987135
SGTC_1875 nocodazole 6 µM -1.99742545873476 0.0200206498148796 no 3274 0.0228894922465967 4706 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_874 0599-0792 117 µM -2.00726547120843 0.0195262039613418 no 3275 0.0223607018196877 4674 765305
SGTC_1699 st031318 29.054 µM -2.02324959933834 0.0187451405234123 no 3276 0.0215237101607007 4727 5340658
SGTC_2388 9080168 200 µM -2.02635211644614 0.0185966582996158 no 3277 0.0213643570623697 4701 15943073
SGTC_2623 humulene 100 µM -2.02887974747565 0.0184764306246773 no 3278 0.0212352700227791 4659 6187145 An anti-inflammatory.
SGTC_1881 5652484 16 µM -2.03097077769269 0.0183774709219149 no 3279 0.0211289795240382 4665 2255129
SGTC_1670 st016595 4.04 µM -2.03998294023954 0.0179561131987449 no 3280 0.0206760124584212 4716 597879
SGTC_2400 5203494 178.7 µM -2.04439706437834 0.0177527574637537 no 3281 0.0204571685457142 4620 6777674
SGTC_2452 5863136 48.41 µM -2.05318767747747 0.0173536279642564 no 3282 0.020027189528451 4658 2184096
SGTC_1550 gossypolone 36.6 µM -2.05687997567531 0.0171882824829705 no 3283 0.0198488862976889 4715 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2857 9024691 58.44 µM -2.06842228417101 0.0166800584776065 no 3284 0.0193001657706218 4694 16478292
SGTC_2911 7942208 15.64 µM -2.07137110645487 0.0165522988506619 no 3285 0.0191620644482292 4672 1243384
SGTC_260 nsc-65238 3.989 µM -2.08816711945494 0.0158404618349879 no 3286 0.0183913810983433 4712 3246252
SGTC_769 0302-0231 76 µM -2.09205599536565 0.0156794406846294 no 3287 0.0182167534725645 4644 571869 YER009W NTF2
SGTC_2109 5483026 200 µM -2.09741358652133 0.0154599078016226 no 3288 0.0179784897023252 4712 759335
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.10260495468497 0.015249708449455 no 3289 0.0177501582333534 4691 61125 An anti-inflammatory.
SGTC_2938 9059746 27.26 µM -2.11844625902765 0.0146233992579369 no 3290 0.0170686458490922 4672 6471769
SGTC_1215 3852-0577 11.2 µM -2.12159983544038 0.0145013951731074 no 3291 0.0169356781132251 4716 2884876
SGTC_1789 tunicamycin 25 nM -2.12509008550894 0.014367388452693 no 3292 0.0167895483519844 4657 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1712 st032288 53.4 µM -2.14383101640327 0.0136659289464131 no 3293 0.016023214578474 4523 2883011
SGTC_2326 6164455 177.58 µM -2.15657815237307 0.013205874448576 no 3294 0.0155192741738273 4654 2888790
SGTC_922 1866-0035 480 µM -2.18025504202824 0.0123867910727626 no 3295 0.014619280803586 4661 3156169
SGTC_2098 5376439 882.5 nM -2.22648339206714 0.0109136676238761 no 3296 0.0129909101004378 4747 2844116
SGTC_1434 4073-0095 163 µM -2.23921417572189 0.0105357713955887 no 3297 0.0125709919615525 4743 24133745
SGTC_737 1950-0117 57.9 µM -2.2428314332404 0.0104304996237066 no 3298 0.0124538433303579 4716 5393513
SGTC_2468 5987765 72.9 µM -2.24588758132073 0.0103422733031057 no 3299 0.0123556047666865 4736 26772094
SGTC_1121 fusaric acid 630.51 nM -2.25724945492286 0.0100199542044767 no 3300 0.0119962458817603 4716 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1123 mangostin 811.285 nM -2.25763068459271 0.010009293036912 no 3301 0.0119843469853305 4726 5281650 An antioxidant.
SGTC_1673 st016611 27.3 µM -2.26257556737728 0.00987190285709391 no 3302 0.0118309328361097 4728 5226799
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -2.27077149793427 0.00964780981191542 no 3303 0.0115804071053906 4766 4213774
SGTC_590 k048-0076 22.4 µM -2.29779668548584 0.0089400814627308 no 3304 0.0107866817555958 4763 6832814
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.30623369305574 0.00872865627933104 no 3305 0.0105487889385298 4778 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2455 5377712 9.75 µM -2.31854309192456 0.0084280579898979 no 3306 0.010209911922168 4745 2243908
SGTC_2706 st078239 82.5 µM -2.33021214951466 0.00815152612910339 no 3307 0.00989747057854237 4724 15434492
SGTC_2715 st079500 56.4 µM -2.33221565969063 0.00810485772574624 no 3308 0.00984467438568513 4743 28246688
SGTC_963 1269-2853 151 µM -2.33292500002865 0.00808839120741144 no 3309 0.00982604100142116 4734 3668223
SGTC_128 0906-2981 13.371 µM -2.34825104948692 0.00773972447934005 no 3310 0.00943090169262416 4737 6740226
SGTC_528 3492-0019 172 µM -2.36700484090681 0.00733112337321546 no 3311 0.00896634912545447 4741 2869262
SGTC_856 0433-0016 11.3 µM -2.37270418524193 0.00721077432969776 no 3312 0.00882919998828155 4762 3911780
SGTC_47 0149-0135 24.25 µM -2.38011460335085 0.00705690121956477 no 3313 0.00865362724700176 4730 5239155
SGTC_682 0kpi-0099 17 µM -2.38140677627781 0.00703036872184549 no 3314 0.00862332773580507 4735 1714895 YML126C ERG13
SGTC_1941 st076221 61.8 µM -2.38310807031739 0.00699556993105849 no 3315 0.00858357688457676 4679 2828568
SGTC_70 0141-0289 43.283 µM -2.38650321287696 0.00692657881999314 no 3316 0.00850472937141116 4728 352408
SGTC_2170 morpholine 200 µM -2.38882310778593 0.00687978347752007 no 3317 0.00845121918675764 4763 121171 Reacts with secondary amines.
SGTC_2561 acetosyringone 100 µM -2.39002718410072 0.00685560590396886 no 3318 0.00842356288826874 4728 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_447 ml7 120 µM -2.39313672537954 0.00679351385194974 no 3319 0.00835250735424319 4771 4216 Selective myosin light chain kinase inhibitor.
SGTC_689 0833-0039 98 µM -2.39433094482393 0.00676979976179011 no 3320 0.00832535865928048 4706 5374726
SGTC_2799 7812892 81.82 µM -2.40102774451675 0.00663816894574266 no 3321 0.00817454843490414 4751 20205235
SGTC_441 propafenone 146 µM -2.40466063773743 0.00656771246891099 no 3322 0.00809374506844459 4744 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2850 9015429 58.44 µM -2.41611565191338 0.00634986419301737 no 3323 0.00784353893985007 4732 6457570
SGTC_1331 1472-0049 76.2 µM -2.41816178157117 0.00631163194416999 no 3324 0.00779956980797539 4752 24051409
SGTC_574 1315-0397 40 µM -2.43263286536737 0.00604700611043306 no 3325 0.00749474546174421 4755 6794277
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.43425133997496 0.00601802998816754 no 3326 0.00746131454393126 4751 756377
SGTC_838 0109-0203 71.4 µM -2.44064529653759 0.00590475671752391 no 3327 0.00733052346042334 4759 759422
SGTC_2854 9024559 71.43 µM -2.48063392114065 0.00523826337187541 no 3328 0.00655744938578177 4731 3163529
SGTC_1451 4152-0210 104 µM -2.4896657011151 0.00509733245823589 no 3329 0.00639316499566194 4769 659563
SGTC_1489 4065-0444 182 µM -2.52110754761107 0.00463268061149637 no 3330 0.00584930452999067 4769 2877968
SGTC_1622 st003707 19.4 µM -2.53074353140086 0.00449804962746746 no 3331 0.00569105200002486 4767 10140899
SGTC_2343 7990716 14.84 µM -2.57256509842842 0.00395334782607697 no 3332 0.00504739846799197 4753 6456862
SGTC_845 0330-0138 4.51 µM -2.6430544820436 0.00316771255428418 no 3333 0.00410809067342273 4760 9039800
SGTC_555 4296-0685 37 µM -2.66651585846984 0.00293925467529882 no 3334 0.00383209952130646 4785 2908540 YHR072W ERG7
SGTC_345 1362-0200 395 µM -2.69374621239753 0.00269279375184821 no 3335 0.00353269700343479 4763 1419823
SGTC_2752 diclazuril 33.15 µM -2.7041184560537 0.00260393335975193 no 3336 0.00342429350062757 4720 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_510 ag-490 170 µM -2.71489901881622 0.00251439078719171 no 3337 0.00331479909878056 4800 5328779
SGTC_461 N-acetylfarnesylcysteine 136 µM -2.72099825764354 0.00246497305182925 no 3338 0.00325425522872682 4792 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1889 st059080 5.18 µM -2.758982455283 0.00217649128629164 no 3339 0.00289908238968846 4762 176925 Isolated from Daphnopsis sellowiana.
SGTC_58 0957-0393 9 µM -2.75920494412727 0.00217489570748687 no 3340 0.0028971092235672 4389 6997992
SGTC_1687 st020778 55.3625 µM -2.90335659951289 0.00133809221624077 no 3341 0.00184593000078842 4802 4259299
SGTC_707 0865-0008 204 µM -2.91178030854187 0.00129979338415836 no 3342 0.00179687648504383 4799 723043
SGTC_2582 agaric acid 100 µM -2.9189272873671 0.00126808804455616 no 3343 0.00175619070900416 4586 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2049 5262831 67.185 µM -2.95778938404468 0.00110773378677157 no 3344 0.00154926877539465 4766 763417
SGTC_1131 3454-3128 32.3 µM -3.05126561546698 0.000795169801303995 yes 3345 0.00113939443268208 4773 710982
SGTC_1754 st042065 16.137 µM -3.11118248255181 0.000639922058924329 yes 3346 0.000931698743089627 4706 1126236 YIL048W NEO1
SGTC_2934 9036370 36.88 µM -3.12867045470966 0.000600194660186833 yes 3347 0.00087799563967168 4779 6462800
SGTC_772 k072-0172 35.3 µM -3.14190759212956 0.000571652689735685 yes 3348 0.000839255010387373 4801 5861980
SGTC_1800 st050079 29.0735 µM -3.18169151608428 0.000493248027604248 yes 3349 0.000732088407330838 4744 3645560
SGTC_1057 3448-5381 134 µM -3.22164692873334 0.000424629058733042 yes 3350 0.000637280463602841 4790 5497911
SGTC_1903 st060211 78.3 µM -3.22798685544851 0.000414592366504575 yes 3351 0.000623323512052335 4798 688960
SGTC_1520 flindersine 88 µM -3.56788448800727 0.000108202735285688 yes 3352 0.000179937540075686 4796 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2798 7813637 45.45 µM -3.59010694268793 9.86922989540417e-05 yes 3353 0.000165271159993392 4796 956368
SGTC_1818 st052136 56.3 µM -3.77003083674147 4.59786949977103e-05 yes 3354 8.16136890422294e-05 4751 674169
SGTC_1847 st056231 15 µM -3.96966588698031 1.89360979513999e-05 yes 3355 3.59867420247732e-05 4797 5393180
SGTC_2793 7325131 81.82 µM -6.10891302105008 9.96549784539299e-11 yes 3356 5.01559873000067e-10 4809 4176441