YAL028W / FRT2

Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL028W / FRT2

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:2.86|P-value:4.33E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.98|P-value:2.54E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.74|P-value:7.04E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:2.67|P-value:9.05E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.20|P-value:9.60E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.58|P-value:1.53E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.47|P-value:2.69E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:-2.91|P-value:4.65E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.01|P-value:3.03E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-2.81|P-value:6.84E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.77|P-value:6.10E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.86|P-value:4.25E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.00|P-value:3.11E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:2.97|P-value:2.67E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:2.75|P-value:6.69E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.85|P-value:4.43E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:2.88|P-value:3.96E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.29|P-value:3.02E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:3.12|P-value:1.41E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.90|P-value:3.56E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.19|P-value:1.02E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.93|P-value:3.21E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.92|P-value:2.55E-6 ID:SGTC_1729|Compound:st035615|FD-Score:-4.71|P-value:3.50E-8 ID:SGTC_1825|Compound:st052143|FD-Score:3.62|P-value:1.28E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.18|P-value:1.47E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.76|P-value:6.44E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.01|P-value:2.24E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.79|P-value:5.72E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.46|P-value:2.78E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.00|P-value:2.35E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.87|P-value:4.09E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.72|P-value:7.41E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.56|P-value:1.73E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.19|P-value:1.38E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.72|P-value:7.46E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:2.10E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.53|P-value:2.76E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.31|P-value:2.77E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.70|P-value:8.00E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.28|P-value:9.39E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:2.86|P-value:4.33E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.98|P-value:2.54E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.74|P-value:7.04E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:2.67|P-value:9.05E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.20|P-value:9.60E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.58|P-value:1.53E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.47|P-value:2.69E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:-2.91|P-value:4.65E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.01|P-value:3.03E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-2.81|P-value:6.84E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:2.77|P-value:6.10E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.86|P-value:4.25E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.00|P-value:3.11E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:2.97|P-value:2.67E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:2.75|P-value:6.69E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.85|P-value:4.43E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:2.88|P-value:3.96E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.29|P-value:3.02E-7 ID:SGTC_1570|Compound:verbenone|FD-Score:3.12|P-value:1.41E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.90|P-value:3.56E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.19|P-value:1.02E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.93|P-value:3.21E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.92|P-value:2.55E-6 ID:SGTC_1729|Compound:st035615|FD-Score:-4.71|P-value:3.50E-8 ID:SGTC_1825|Compound:st052143|FD-Score:3.62|P-value:1.28E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.18|P-value:1.47E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.76|P-value:6.44E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.01|P-value:2.24E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.79|P-value:5.72E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.46|P-value:2.78E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.00|P-value:2.35E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:2.87|P-value:4.09E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.72|P-value:7.41E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.56|P-value:1.73E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.19|P-value:1.38E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.72|P-value:7.46E-4 ID:SGTC_2946|Compound:9065502|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.59|P-value:2.10E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.53|P-value:2.76E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.31|P-value:2.77E-7 ID:SGTC_3060|Compound:1327-0027|FD-Score:2.70|P-value:8.00E-4 ID:SGTC_3192|Compound:9110362|FD-Score:-3.28|P-value:9.39E-5

Top fitness defect scores for YAL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2965 9082772 4.31 38.6 µM 2.77E-7 mitochondrial response to ROS 30 8.20E-6
2 SGTC_1531 st059297 4.29 52.4 µM 3.02E-7 7 8.74E-6
3 SGTC_1727 st034309 3.92 9.9 µM 2.55E-6 40 4.39E-5
4 SGTC_1825 st052143 3.62 62.6 µM 1.28E-5 22 1.49E-4
5 SGTC_344 k064-0035 3.58 6.4 µM 1.53E-5 60S ribosome export 31 1.70E-4
6 SGTC_2806 7952793 3.56 58.4 µM 1.73E-5 37 1.87E-4
7 SGTC_564 3555-0129 3.47 330.0 µM 2.69E-5 11 2.61E-4
8 SGTC_2167 5876490 3.46 200.0 µM 2.78E-5 50 2.68E-4
9 SGTC_326 k292-0812 3.20 17.5 µM 9.60E-5 20 6.85E-4
10 SGTC_1642 st009582 3.19 77.7 µM 1.02E-4 RPP1 & pyrimidine depletion 41 7.19E-4
11 SGTC_1570 verbenone 3.12 133.0 µM 1.41E-4 40 9.17E-4
12 SGTC_2946 9065502 3.06 71.4 µM 1.83E-4 25 0.00112
13 SGTC_2158 5657123 3.06 3.6 µM 1.83E-4 25 0.00112
14 SGTC_2143 5623677 3.01 140.5 µM 2.24E-4 23 0.00130
15 SGTC_2476 5806916 3.00 10.5 µM 2.35E-4 52 0.00135
16 SGTC_2318 6029776 3.00 164.0 µM 2.39E-4 78 0.00137
17 SGTC_69 0096-0274 2.98 206.7 µM 2.54E-4 mitochondrial processes 108 0.00144
18 SGTC_1099 5-nonyloxytryptamine 2.97 2.9 µM 2.67E-4 60 0.00149
19 SGTC_1705 st027868 2.93 56.3 µM 3.21E-4 48 0.00171
20 SGTC_1607 st000305 2.90 50.6 µM 3.56E-4 51 0.00185

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.01E-17 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.121 2.23E-12 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.111 1.15E-10 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.100 7.08E-9 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.096 2.59E-8 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.095 3.84E-8 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.094 5.50E-8 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.090 2.02E-7 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.089 2.48E-7 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.088 3.79E-7 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.086 5.52E-7 YJR015W_p YJR015W_p hom Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
0.086 5.92E-7 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.086 6.10E-7 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.086 6.89E-7 YBL027W RPL19B hom Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication
0.083 1.40E-6 YNL068C FKH2 hom Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication