YAL042C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL042C-A / YAL042C-A

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:3.54|P-value:2.01E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.29|P-value:4.99E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.11|P-value:1.65E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:6.95E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.23|P-value:6.25E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.07|P-value:2.41E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.69|P-value:1.10E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-4.11|P-value:1.92E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.76|P-value:8.45E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.35|P-value:3.92E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.99|P-value:3.34E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.93|P-value:4.26E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.28|P-value:5.13E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.13|P-value:8.73E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.70|P-value:1.05E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.80|P-value:7.16E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.49|P-value:2.38E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.74|P-value:1.05E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.10|P-value:9.70E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.59|P-value:2.23E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.20|P-value:6.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.72|P-value:9.63E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:6.05|P-value:7.24E-10 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.14|P-value:8.50E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.22|P-value:1.23E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:8.56E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.23|P-value:1.19E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.05|P-value:2.60E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.45|P-value:2.72E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.58|P-value:1.23E-8 ID:SGTC_1868|Compound:st057644|FD-Score:-3.24|P-value:5.90E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.27|P-value:5.21E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.32|P-value:4.57E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.17|P-value:7.65E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.83|P-value:6.52E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.56|P-value:1.84E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.18|P-value:7.24E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.10|P-value:9.61E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.31|P-value:4.74E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.48|P-value:2.50E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.77|P-value:9.31E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.18|P-value:7.30E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.06|P-value:2.52E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.35|P-value:4.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.18|P-value:7.37E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.24|P-value:5.98E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.02|P-value:1.10E-12 ID:SGTC_3213|Compound:9129884|FD-Score:-3.70|P-value:1.07E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-6.45|P-value:5.34E-11 ID:SGTC_3220|Compound:9131269|FD-Score:-3.92|P-value:4.28E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.02|P-value:2.96E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.54|P-value:2.01E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.29|P-value:4.99E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.11|P-value:1.65E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.20|P-value:6.95E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.23|P-value:6.25E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.07|P-value:2.41E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.69|P-value:1.10E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-4.11|P-value:1.92E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.76|P-value:8.45E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.40|P-value:3.46E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.35|P-value:3.92E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.99|P-value:3.34E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.93|P-value:4.26E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.28|P-value:5.13E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.13|P-value:8.73E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.70|P-value:1.05E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.80|P-value:7.16E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.49|P-value:2.38E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.74|P-value:1.05E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.10|P-value:9.70E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.59|P-value:2.23E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.20|P-value:6.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.72|P-value:9.63E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:6.05|P-value:7.24E-10 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.14|P-value:8.50E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.22|P-value:1.23E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.14|P-value:8.56E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.23|P-value:1.19E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.05|P-value:2.60E-5 ID:SGTC_1782|Compound:st039423|FD-Score:-3.45|P-value:2.72E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.58|P-value:1.23E-8 ID:SGTC_1868|Compound:st057644|FD-Score:-3.24|P-value:5.90E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.27|P-value:5.21E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.32|P-value:4.57E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.17|P-value:7.65E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.16|P-value:7.98E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.22|P-value:6.36E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.83|P-value:6.52E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.56|P-value:1.84E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.17|P-value:7.61E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.18|P-value:7.24E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.10|P-value:9.61E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.31|P-value:4.74E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.48|P-value:2.50E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.77|P-value:9.31E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.18|P-value:7.30E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.06|P-value:2.52E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.35|P-value:4.14E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.28|P-value:5.14E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.18|P-value:7.37E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.24|P-value:5.98E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.02|P-value:1.10E-12 ID:SGTC_3213|Compound:9129884|FD-Score:-3.70|P-value:1.07E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-6.45|P-value:5.34E-11 ID:SGTC_3220|Compound:9131269|FD-Score:-3.92|P-value:4.28E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.02|P-value:2.96E-5

Top fitness defect scores for YAL042C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1252 0493-0875 6.05 34.8 µM 7.24E-10 4 7.18E-10
2 SGTC_1787 fluconazole 5.58 80.0 µM 1.23E-8 iron homeostasis 4 1.22E-8
3 SGTC_184 1494-0393 5.11 24.7 µM 1.65E-7 28 1.64E-7
4 SGTC_2989 9073649 4.77 71.4 µM 9.31E-7 16 9.24E-7
5 SGTC_867 0518-0118 4.74 155.0 µM 1.05E-6 DNA intercalators 10 1.04E-6
6 SGTC_926 2268-1401 4.59 59.4 µM 2.23E-6 TSC3-RPN4 20 2.21E-6
7 SGTC_1533 dihydroergotamine mesylate 4.23 29.4 µM 1.19E-5 DNA intercalators 10 1.19E-5
8 SGTC_652 0437-0092 4.23 114.0 µM 1.20E-5 6 1.19E-5
9 SGTC_1527 coumarin 4.22 137.0 µM 1.23E-5 18 1.22E-5
10 SGTC_302 1094-0063 4.07 18.9 µM 2.41E-5 10 2.39E-5
11 SGTC_3129 9127257 4.06 49.5 µM 2.52E-5 22 2.50E-5
12 SGTC_1625 st003711 4.05 30.1 µM 2.60E-5 calcium & mitochondrial duress 33 2.58E-5
13 SGTC_3339 9145883 4.02 14.9 µM 2.96E-5 12 2.94E-5
14 SGTC_542 3381-0244 3.99 89.3 µM 3.34E-5 38 3.31E-5
15 SGTC_2721 ifenprodil 3.83 61.4 µM 6.52E-5 plasma membrane duress 23 6.47E-5
16 SGTC_593 1203-0218 3.80 61.7 µM 7.16E-5 11 7.11E-5
17 SGTC_396 dithiazanine 3.76 1.2 µM 8.45E-5 9 8.39E-5
18 SGTC_1869 3',7'-dimethoxyflavone 3.73 40.3 µM 9.65E-5 33 9.58E-5
19 SGTC_1349 flufenamic acid 3.60 69.0 µM 1.59E-4 23 1.58E-4
20 SGTC_2744 captopril 3.56 92.0 µM 1.84E-4 60S ribosome export 18 1.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.41E-8 YOR183W_p FYV12_p hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.090 1.76E-7 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.086 6.25E-7 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.084 1.14E-6 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.084 1.20E-6 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.081 2.30E-6 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.081 3.02E-6 YBR281C DUG2 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.080 3.12E-6 YER149C PEA2 hom Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
0.079 4.03E-6 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.077 7.69E-6 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.076 9.32E-6 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.076 9.89E-6 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.075 1.32E-5 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.075 1.40E-5 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.075 1.46E-5 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex