HIPHOP chemogenomics database

YAL045C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A

Zygosity: Homozygous strain

fixedexpanded
Profile for YAL045C / YAL045C

Click on Significant Values for Screen Details

Top fitness defect scores for YAL045C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_360	0957-0399	4.30	1.0 µM	1.41E-6	cell wall	36	8.48E-6
2	SGTC_2602	kawain	4.05	100.0 µM	5.14E-6		22	2.56E-5
3	SGTC_527	4476-4215	3.98	268.0 µM	7.35E-6	PDR1	33	3.47E-5
4	SGTC_2295	7971645	3.92	200.0 µM	9.90E-6		21	4.49E-5
5	SGTC_1804	st050076	3.76	49.1 µM	2.08E-5		19	8.46E-5
6	SGTC_907	3448-6986	3.59	75.5 µM	4.61E-5		38	1.67E-4
7	SGTC_645	0845-0943	3.52	5.4 µM	6.25E-5	60S ribosome export	17	2.17E-4
8	SGTC_2629	bisabolol	3.49	100.0 µM	7.01E-5		34	2.39E-4
9	SGTC_2361	9034121	3.48	116.0 µM	7.38E-5	RSC complex & mRNA processing	32	2.50E-4
10	SGTC_1177	0983-0204	3.27	23.6 µM	1.81E-4		32	5.38E-4
11	SGTC_2605	digitonin	3.26	300.0 nM	1.86E-4		61	5.51E-4
12	SGTC_910	3454-3003	3.26	490.0 µM	1.90E-4		40	5.62E-4
13	SGTC_1332	1480-0653	3.24	17.5 µM	2.03E-4	TSC3-RPN4	37	5.94E-4
14	SGTC_2167	5876490	3.24	200.0 µM	2.05E-4		66	6.00E-4
15	SGTC_669	0108-0021	3.23	26.2 µM	2.17E-4	fatty acid desaturase (OLE1)	135	6.28E-4
16	SGTC_361	000s-0510	3.19	1.4 µM	2.51E-4		67	7.12E-4
17	SGTC_164	4100-3994	3.15	89.6 µM	3.00E-4		77	8.29E-4
18	SGTC_3313	9133968	2.97	57.0 µM	5.91E-4		38	0.00148
19	SGTC_2813	7971799	2.93	71.4 µM	6.83E-4		69	0.00168
20	SGTC_532	1548-0774	2.86	215.0 µM	8.98E-4		66	0.00212

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.318	1.01E-79	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.204	9.42E-33	YER030W	CHZ1	hom	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.198	5.35E-31	YMR095C	SNO1	hom	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.179	1.65E-25	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.174	3.67E-24	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.173	4.61E-24	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.167	2.10E-22	YLL012W	YEH1	hom	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.167	2.65E-22	YLR288C	MEC3	hom	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.165	8.09E-22	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.164	9.21E-22	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.163	2.12E-21	YER060W-A	FCY22	hom	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.161	4.99E-21	YKL099C	UTP11	het	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.160	1.13E-20	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.156	1.05E-19	YGR097W	ASK10	hom	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.153	5.00E-19	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth