YAL046C / AIM1

Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL046C / AIM1

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:4.40|P-value:1.13E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.69|P-value:1.90E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.54|P-value:3.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.28|P-value:7.90E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.26|P-value:8.43E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.90|P-value:8.80E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.53|P-value:3.37E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.23|P-value:9.45E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.33|P-value:6.75E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.50|P-value:3.66E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.18|P-value:2.86E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.82|P-value:1.19E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.38|P-value:5.67E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.35|P-value:6.20E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.48|P-value:4.05E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.24|P-value:9.13E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.56|P-value:3.06E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.59|P-value:4.96E-6 ID:SGTC_1899|Compound:st063254|FD-Score:3.45|P-value:4.53E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.20|P-value:2.53E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.06|P-value:4.45E-5 ID:SGTC_2025|Compound:5147754|FD-Score:4.74|P-value:2.49E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.70|P-value:1.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.85|P-value:1.01E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-6.01|P-value:3.52E-9 ID:SGTC_2282|Compound:7944268|FD-Score:3.68|P-value:2.01E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.60|P-value:2.62E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.34|P-value:6.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.45|P-value:4.44E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.83|P-value:9.68E-9 ID:SGTC_2969|Compound:9091408|FD-Score:7.27|P-value:1.27E-12 ID:SGTC_3254|Compound:9136651|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.90|P-value:8.58E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.99|P-value:5.92E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.43|P-value:4.75E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.40|P-value:1.13E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:3.69|P-value:1.90E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.54|P-value:3.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.28|P-value:7.90E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.26|P-value:8.43E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.90|P-value:8.80E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.53|P-value:3.37E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.23|P-value:9.45E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.33|P-value:6.75E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.50|P-value:3.66E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.18|P-value:2.86E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.82|P-value:1.19E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.38|P-value:5.67E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.35|P-value:6.20E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.48|P-value:4.05E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.24|P-value:9.13E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.56|P-value:3.06E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.59|P-value:4.96E-6 ID:SGTC_1899|Compound:st063254|FD-Score:3.45|P-value:4.53E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.20|P-value:2.53E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-4.06|P-value:4.45E-5 ID:SGTC_2025|Compound:5147754|FD-Score:4.74|P-value:2.49E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.70|P-value:1.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.85|P-value:1.01E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-6.01|P-value:3.52E-9 ID:SGTC_2282|Compound:7944268|FD-Score:3.68|P-value:2.01E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.60|P-value:2.62E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.34|P-value:6.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.45|P-value:4.44E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.28|P-value:7.98E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.83|P-value:9.68E-9 ID:SGTC_2969|Compound:9091408|FD-Score:7.27|P-value:1.27E-12 ID:SGTC_3254|Compound:9136651|FD-Score:3.24|P-value:9.18E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.90|P-value:8.58E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.99|P-value:5.92E-5 ID:SGTC_3332|Compound:9141069|FD-Score:3.43|P-value:4.75E-4

Top fitness defect scores for YAL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2969 9091408 7.27 28.7 µM 1.27E-12 2 1.82E-13
2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.83 100.0 µM 9.68E-9 11 2.73E-9
3 SGTC_2025 5147754 4.74 141.0 µM 2.49E-6 3 1.06E-6
4 SGTC_1525 8-methoxypsoralen 4.59 92.5 µM 4.96E-6 DNA damage response 17 2.23E-6
5 SGTC_123 0083-0120 4.40 66.7 µM 1.13E-5 35 5.38E-6
6 SGTC_899 1083-0020 4.18 478.0 µM 2.86E-5 18 1.46E-5
7 SGTC_3298 9116858 3.90 71.4 µM 8.58E-5 10 4.76E-5
8 SGTC_574 1315-0397 3.90 40.0 µM 8.80E-5 38 4.90E-5
9 SGTC_1022 4477-0945 3.82 21.3 µM 1.19E-4 27 6.79E-5
10 SGTC_2050 5263056 3.70 171.0 µM 1.87E-4 fatty acid desaturase (OLE1) 55 1.10E-4
11 SGTC_157 1348-1695 3.69 65.8 µM 1.90E-4 iron homeostasis 89 1.12E-4
12 SGTC_2282 7944268 3.68 200.0 µM 2.01E-4 RPP1 & pyrimidine depletion 44 1.19E-4
13 SGTC_639 0833-0042 3.60 114.0 µM 2.68E-4 57 1.62E-4
14 SGTC_1496 4469-0713 3.56 57.4 µM 3.06E-4 30 1.87E-4
15 SGTC_302 1094-0063 3.54 18.9 µM 3.24E-4 19 1.98E-4
16 SGTC_604 1000-0114 3.53 314.0 µM 3.37E-4 37 2.07E-4
17 SGTC_1294 1000-1494 3.48 117.0 µM 4.05E-4 36 2.52E-4
18 SGTC_2460 5552655 3.45 174.2 µM 4.44E-4 amide catabolism 45 2.78E-4
19 SGTC_1899 st063254 3.45 59.6 µM 4.53E-4 24 2.84E-4
20 SGTC_3332 9141069 3.43 11.2 µM 4.75E-4 33 2.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.34E-12 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.104 1.76E-9 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.102 3.63E-9 YGR254W ENO1 hom Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress
0.100 7.30E-9 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.094 4.64E-8 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.089 2.86E-7 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.54E-7 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.084 1.00E-6 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.083 1.55E-6 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.080 3.76E-6 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.077 7.06E-6 YGR062C COX18 hom Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
0.076 9.19E-6 YGR238C KEL2 hom Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.076 9.38E-6 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.075 1.26E-5 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.074 1.83E-5 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress