YAL049C / AIM2

Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL049C / AIM2

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.01|P-value:7.51E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.61|P-value:7.09E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.20|P-value:3.73E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.06|P-value:6.01E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.29|P-value:3.10E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.09|P-value:5.69E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.29|P-value:2.70E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.44|P-value:1.44E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.19|P-value:5.05E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.65|P-value:5.96E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.24|P-value:3.25E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:3.17E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-2.92|P-value:9.85E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.15|P-value:4.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.81|P-value:3.02E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.05|P-value:6.55E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.49|P-value:1.09E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.06|P-value:6.33E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:7.68E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.10|P-value:5.44E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.73|P-value:5.70E-13 ID:SGTC_2694|Compound:st077685|FD-Score:-7.71|P-value:1.84E-16 ID:SGTC_2794|Compound:7785382|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.97|P-value:8.32E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.09|P-value:5.70E-4 ID:SGTC_2964|Compound:9083345|FD-Score:7.10|P-value:3.49E-14 ID:SGTC_3072|Compound:9116419|FD-Score:-3.07|P-value:5.83E-4 ID:SGTC_3100|Compound:9120536|FD-Score:5.17|P-value:2.58E-8 ID:SGTC_3107|Compound:9121808|FD-Score:3.64|P-value:6.30E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-6.25|P-value:1.98E-11 ID:SGTC_3140|Compound:9094243|FD-Score:-5.29|P-value:1.08E-8 ID:SGTC_3148|Compound:9097893|FD-Score:-3.83|P-value:2.56E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.32|P-value:2.20E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.13|P-value:4.53E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.08|P-value:5.46E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.01|P-value:7.51E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.61|P-value:7.09E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.20|P-value:3.73E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.06|P-value:6.01E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.29|P-value:3.10E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.09|P-value:5.69E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.29|P-value:2.70E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.44|P-value:1.44E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.19|P-value:5.05E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.65|P-value:5.96E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.24|P-value:3.25E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.50|P-value:1.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.45|P-value:1.39E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.24|P-value:3.17E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-2.92|P-value:9.85E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.15|P-value:4.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.81|P-value:3.02E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.05|P-value:6.55E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.30|P-value:2.51E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.49|P-value:1.09E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.06|P-value:6.33E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:7.68E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.10|P-value:5.44E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.73|P-value:5.70E-13 ID:SGTC_2694|Compound:st077685|FD-Score:-7.71|P-value:1.84E-16 ID:SGTC_2794|Compound:7785382|FD-Score:3.00|P-value:7.94E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-2.97|P-value:8.32E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.09|P-value:5.70E-4 ID:SGTC_2964|Compound:9083345|FD-Score:7.10|P-value:3.49E-14 ID:SGTC_3072|Compound:9116419|FD-Score:-3.07|P-value:5.83E-4 ID:SGTC_3100|Compound:9120536|FD-Score:5.17|P-value:2.58E-8 ID:SGTC_3107|Compound:9121808|FD-Score:3.64|P-value:6.30E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-6.25|P-value:1.98E-11 ID:SGTC_3140|Compound:9094243|FD-Score:-5.29|P-value:1.08E-8 ID:SGTC_3148|Compound:9097893|FD-Score:-3.83|P-value:2.56E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.32|P-value:2.20E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.13|P-value:4.53E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.69|P-value:5.05E-5 ID:SGTC_3332|Compound:9141069|FD-Score:-3.08|P-value:5.46E-4

Top fitness defect scores for YAL049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2964 9083345 7.10 53.4 µM 3.49E-14 2 6.28E-13
2 SGTC_3100 9120536 5.17 49.5 µM 2.58E-8 3 1.20E-7
3 SGTC_2597 laccaic acid a 4.56 100.0 µM 7.68E-7 18 2.56E-6
4 SGTC_212 3807-4682 4.29 38.8 µM 3.10E-6 tubulin folding & SWR complex 52 8.99E-6
5 SGTC_772 k072-0172 4.19 35.3 µM 5.05E-6 15 1.40E-5
6 SGTC_1741 st038134 3.81 10.2 µM 3.02E-5 36 7.03E-5
7 SGTC_3209 9113616 3.69 49.5 µM 5.05E-5 34 1.12E-4
8 SGTC_846 0335-0850 3.65 148.0 µM 5.96E-5 ubiquinone biosynthesis & proteasome 38 1.30E-4
9 SGTC_3107 9121808 3.64 49.5 µM 6.30E-5 8 1.37E-4
10 SGTC_43 0570-0105 3.61 72.5 µM 7.09E-5 ERG2 120 1.52E-4
11 SGTC_2130 NSC 7 3.53 2.5 µM 1.01E-4 copper-dependent oxidative stress 47 2.09E-4
12 SGTC_1381 2324-0066 3.49 62.1 µM 1.17E-4 45 2.40E-4
13 SGTC_1044 1222-0021 3.45 1.8 µM 1.39E-4 heme biosynthesis & mitochondrial translocase 52 2.80E-4
14 SGTC_746 1095-0025 3.44 46.6 µM 1.44E-4 RSC & ERG11 27 2.88E-4
15 SGTC_1524 corynanthine 3.32 62.1 µM 2.32E-4 42 4.45E-4
16 SGTC_2685 mycophenolic acid 3.31 18.9 µM 2.48E-4 RNA pol III & RNase P/MRP 18 4.71E-4
17 SGTC_1966 st070145 3.30 16.1 µM 2.51E-4 45 4.76E-4
18 SGTC_318 1488-0629 3.29 67.2 µM 2.70E-4 copper-dependent oxidative stress 42 5.10E-4
19 SGTC_1230 0170-0365 3.24 3.8 µM 3.17E-4 endomembrane recycling 112 5.88E-4
20 SGTC_854 0422-0053 3.24 192.0 µM 3.25E-4 PDR1 33 6.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.32E-11 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.110 1.50E-10 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.110 1.76E-10 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.110 1.86E-10 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.110 1.89E-10 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.096 2.51E-8 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.095 2.99E-8 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.089 2.34E-7 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.088 2.87E-7 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.088 2.97E-7 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.088 3.57E-7 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.086 6.54E-7 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.085 7.98E-7 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.082 1.86E-6 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.081 2.41E-6 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter