YAL066W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL066W / YAL066W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:4.28|P-value:4.07E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.02|P-value:1.07E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.43|P-value:7.17E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.39|P-value:2.26E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.37|P-value:3.73E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.13|P-value:7.07E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.57|P-value:4.49E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.77|P-value:2.60E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.34|P-value:9.50E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.72|P-value:2.74E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.61|P-value:4.03E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.80|P-value:2.09E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.67|P-value:3.26E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.68|P-value:6.88E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.76|P-value:2.70E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.49|P-value:5.91E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-4.08|P-value:7.42E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.29|P-value:2.67E-9 ID:SGTC_2174|Compound:5790901|FD-Score:-4.93|P-value:2.40E-6 ID:SGTC_2175|Compound:5807670|FD-Score:-7.51|P-value:1.69E-12 ID:SGTC_2176|Compound:5809774|FD-Score:-7.06|P-value:2.99E-11 ID:SGTC_2185|Compound:6113692|FD-Score:-4.43|P-value:1.98E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.07|P-value:9.11E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.69|P-value:3.41E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.44|P-value:6.99E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.53|P-value:1.53E-5 ID:SGTC_2707|Compound:st078556|FD-Score:-3.57|P-value:4.55E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.97|P-value:1.11E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.46|P-value:6.42E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.78|P-value:2.21E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.38|P-value:8.41E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.59|P-value:4.29E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.49|P-value:5.85E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.85|P-value:3.37E-6 ID:SGTC_3288|Compound:9119690|FD-Score:5.17|P-value:9.42E-7 ID:SGTC_3304|Compound:9125678|FD-Score:4.79|P-value:5.04E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:4.28|P-value:4.07E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:4.02|P-value:1.07E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.43|P-value:7.17E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.39|P-value:2.26E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.37|P-value:3.73E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.13|P-value:7.07E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.57|P-value:4.49E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.77|P-value:2.60E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.34|P-value:9.50E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.72|P-value:2.74E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.61|P-value:4.03E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.80|P-value:2.09E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.67|P-value:3.26E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-4.68|P-value:6.88E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.76|P-value:2.70E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.49|P-value:5.91E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-4.08|P-value:7.42E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.29|P-value:2.67E-9 ID:SGTC_2174|Compound:5790901|FD-Score:-4.93|P-value:2.40E-6 ID:SGTC_2175|Compound:5807670|FD-Score:-7.51|P-value:1.69E-12 ID:SGTC_2176|Compound:5809774|FD-Score:-7.06|P-value:2.99E-11 ID:SGTC_2185|Compound:6113692|FD-Score:-4.43|P-value:1.98E-5 ID:SGTC_2364|Compound:9055074|FD-Score:4.07|P-value:9.11E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.69|P-value:3.41E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.44|P-value:6.99E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.53|P-value:1.53E-5 ID:SGTC_2707|Compound:st078556|FD-Score:-3.57|P-value:4.55E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.97|P-value:1.11E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.46|P-value:6.42E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.78|P-value:2.21E-4 ID:SGTC_3024|Compound:9090631|FD-Score:-3.38|P-value:8.41E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.59|P-value:4.29E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.49|P-value:5.85E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.85|P-value:3.37E-6 ID:SGTC_3288|Compound:9119690|FD-Score:5.17|P-value:9.42E-7 ID:SGTC_3304|Compound:9125678|FD-Score:4.79|P-value:5.04E-6

Top fitness defect scores for YAL066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_451 chloral hydrate 5.37 100.0 µM 3.73E-7 20 3.94E-8
2 SGTC_3288 9119690 5.17 36.2 µM 9.42E-7 12 1.16E-7
3 SGTC_3304 9125678 4.79 46.1 µM 5.04E-6 24 8.22E-7
4 SGTC_2695 st077686 4.53 52.0 µM 1.53E-5 23 3.00E-6
5 SGTC_44 0929-0055 4.28 61.2 µM 4.07E-5 26 9.36E-6
6 SGTC_501 nsc-95397 4.13 161.0 µM 7.07E-5 12 1.78E-5
7 SGTC_2364 9055074 4.07 200.0 µM 9.11E-5 19 2.40E-5
8 SGTC_103 0844-0104 4.02 51.8 µM 1.07E-4 ERAD & cell cycle 141 2.88E-5
9 SGTC_507 nimesulide 3.77 162.0 µM 2.60E-4 19 8.13E-5
10 SGTC_1707 st032323 3.76 6.3 µM 2.70E-4 DNA damage response 63 8.51E-5
11 SGTC_2368 9071271 3.69 200.0 µM 3.41E-4 43 1.11E-4
12 SGTC_2857 9024691 3.35 58.4 µM 0.00103 42 4.03E-4
13 SGTC_2758 dehydroepiandrosterone 3.34 69.3 µM 0.00106 66 4.19E-4
14 SGTC_1324 1418-0026 3.27 34.4 µM 0.00133 32 5.44E-4
15 SGTC_2694 st077685 3.21 81.9 µM 0.00158 endomembrane recycling 56 6.61E-4
16 SGTC_1711 st032263 3.21 62.8 µM 0.00159 39 6.70E-4
17 SGTC_1484 3473-2379 3.20 286.0 µM 0.00161 44 6.75E-4
18 SGTC_2183 6420625 3.19 130.5 µM 0.00165 mitochondrial processes 97 6.99E-4
19 SGTC_2172 5754775 3.09 163.9 µM 0.00224 48 9.96E-4
20 SGTC_1331 1472-0049 3.09 76.2 µM 0.00225 60 9.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.33E-31 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.189 3.60E-28 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.158 3.05E-20 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.149 3.73E-18 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.145 3.84E-17 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.135 3.95E-15 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.128 9.87E-14 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.128 1.03E-13 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.118 7.66E-12 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.113 4.67E-11 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.112 8.15E-11 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.112 8.30E-11 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.107 4.80E-10 YGR157W CHO2 hom Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
0.104 1.57E-9 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.101 4.04E-9 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication