YAR030C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR030C / YAR030C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.72|P-value:5.93E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.26|P-value:3.70E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.71|P-value:6.14E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.26|P-value:3.65E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.51|P-value:1.37E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.30|P-value:3.21E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.08|P-value:7.14E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:8.31|P-value:3.43E-18 ID:SGTC_975|Compound:1335-0046|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.06|P-value:7.87E-8 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.18|P-value:4.91E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.16|P-value:5.38E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.80|P-value:4.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.20|P-value:6.80E-6 ID:SGTC_1799|Compound:st045822|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.28|P-value:3.35E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.45|P-value:8.00E-9 ID:SGTC_2342|Compound:7990637|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:1.78E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.20|P-value:4.62E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.45|P-value:7.56E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.08|P-value:1.18E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.01|P-value:9.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.52|P-value:1.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.53|P-value:1.20E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.88|P-value:2.90E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.15|P-value:5.54E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.74|P-value:5.42E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-3.49|P-value:1.44E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.22|P-value:6.04E-6 ID:SGTC_3289|Compound:9119912|FD-Score:3.89|P-value:2.79E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.72|P-value:5.93E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.22|P-value:4.28E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.26|P-value:3.70E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.71|P-value:6.14E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.26|P-value:3.65E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.59|P-value:1.02E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.51|P-value:1.37E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.30|P-value:3.21E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.08|P-value:7.14E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:8.31|P-value:3.43E-18 ID:SGTC_975|Compound:1335-0046|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.40|P-value:2.12E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.06|P-value:7.87E-8 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.18|P-value:4.91E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.05|P-value:7.91E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.16|P-value:5.38E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.80|P-value:4.02E-5 ID:SGTC_1794|Compound:st048918|FD-Score:4.20|P-value:6.80E-6 ID:SGTC_1799|Compound:st045822|FD-Score:4.54|P-value:1.28E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.58|P-value:1.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.28|P-value:3.35E-4 ID:SGTC_2286|Compound:7945697|FD-Score:5.45|P-value:8.00E-9 ID:SGTC_2342|Compound:7990637|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.99|P-value:1.78E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.20|P-value:4.62E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.45|P-value:7.56E-9 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.08|P-value:1.18E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.01|P-value:9.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.52|P-value:1.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.53|P-value:1.20E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.88|P-value:2.90E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.15|P-value:5.54E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.74|P-value:5.42E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-3.49|P-value:1.44E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.22|P-value:6.04E-6 ID:SGTC_3289|Compound:9119912|FD-Score:3.89|P-value:2.79E-5

Top fitness defect scores for YAR030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_792 4534-1957 8.31 155.0 µM 3.43E-18 2 4.66E-17
2 SGTC_2286 7945697 5.45 125.0 µM 8.00E-9 23 2.48E-8
3 SGTC_1260 0700-1617 5.06 7.8 µM 7.87E-8 calcium & mitochondrial duress 15 2.09E-7
4 SGTC_1799 st045822 4.54 46.1 µM 1.28E-6 4 2.82E-6
5 SGTC_3245 9134821 4.22 49.5 µM 6.04E-6 11 1.20E-5
6 SGTC_1794 st048918 4.20 76.9 µM 6.80E-6 10 1.34E-5
7 SGTC_2596 sinensetin 4.08 100.0 µM 1.18E-5 31 2.24E-5
8 SGTC_2406 ethylparaben 3.99 405.7 µM 1.78E-5 36 3.29E-5
9 SGTC_3289 9119912 3.89 71.4 µM 2.79E-5 17 4.99E-5
10 SGTC_3087 9117406 3.88 49.5 µM 2.90E-5 19 5.18E-5
11 SGTC_3173 9105693 3.74 49.5 µM 5.42E-5 25 9.30E-5
12 SGTC_57 miconazole 3.72 162.5 nM 5.93E-5 ergosterol depletion effects on membrane 28 1.01E-4
13 SGTC_219 mitoxanthrone 3.71 164.4 µM 6.14E-5 DNA intercalators 58 1.04E-4
14 SGTC_274 sirtinol 3.59 40.1 µM 1.02E-4 30 1.68E-4
15 SGTC_2880 9042983 3.58 58.4 µM 1.05E-4 fatty acid desaturase (OLE1) 39 1.72E-4
16 SGTC_2885 9057732 3.52 52.0 µM 1.34E-4 24 2.17E-4
17 SGTC_351 caspofungin 3.51 25.0 nM 1.37E-4 cell wall 130 2.21E-4
18 SGTC_2342 7990637 3.44 118.9 µM 1.82E-4 RNA processing & uracil transport 58 2.88E-4
19 SGTC_1002 4049-0206 3.40 172.0 µM 2.12E-4 62 3.32E-4
20 SGTC_618 k072-0232 3.30 33.2 µM 3.21E-4 60S ribosome export 24 4.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.50E-11 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.108 3.70E-10 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.102 3.94E-9 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
0.096 2.31E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.093 5.92E-8 YFL053W DAK2 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.090 1.63E-7 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.089 2.14E-7 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.089 2.65E-7 YOR343C_d YOR343C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.42E-7 YJL216C IMA5 hom Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
0.086 5.36E-7 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.086 5.97E-7 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.083 1.34E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.082 1.83E-6 YML115C VAN1 hom Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.082 2.23E-6 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.080 3.17E-6 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth