YAR031W / PRM9

Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR031W / PRM9

Click on Significant Values for Screen Details ID:SGTC_181|Compound:1447-1644|FD-Score:3.98|P-value:5.83E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.08|P-value:3.93E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.34|P-value:1.35E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.19|P-value:9.89E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.61|P-value:4.05E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.27|P-value:8.39E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.95|P-value:7.30E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.88|P-value:9.64E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.62|P-value:2.56E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.21|P-value:9.35E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.27|P-value:8.50E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:7.16|P-value:2.17E-12 ID:SGTC_1259|Compound:0671-0132|FD-Score:5.12|P-value:3.67E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.10|P-value:3.59E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.25|P-value:8.26E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.80|P-value:1.34E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-3.54|P-value:3.38E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.49|P-value:5.44E-8 ID:SGTC_1736|Compound:st036774|FD-Score:-3.90|P-value:9.17E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.36|P-value:5.55E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.24|P-value:9.25E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.49|P-value:3.61E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.97|P-value:5.96E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.74|P-value:1.64E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.30|P-value:6.92E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.24|P-value:2.03E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.50|P-value:3.95E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.46|P-value:3.94E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.42|P-value:5.12E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.50|P-value:3.89E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.82|P-value:1.07E-4 ID:SGTC_2333|Compound:9017922|FD-Score:6.48|P-value:1.83E-10 ID:SGTC_2339|Compound:9000433|FD-Score:4.03|P-value:4.74E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.48|P-value:7.20E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.35|P-value:1.48E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.80|P-value:1.18E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.31|P-value:7.56E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.33|P-value:6.22E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.98|P-value:5.83E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.08|P-value:3.93E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.34|P-value:1.35E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:3.19|P-value:9.89E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.61|P-value:4.05E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.27|P-value:8.39E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.95|P-value:7.30E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.88|P-value:9.64E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.62|P-value:2.56E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.21|P-value:9.35E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.27|P-value:8.50E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:7.16|P-value:2.17E-12 ID:SGTC_1259|Compound:0671-0132|FD-Score:5.12|P-value:3.67E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.10|P-value:3.59E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.25|P-value:8.26E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:-3.80|P-value:1.34E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-3.54|P-value:3.38E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.49|P-value:5.44E-8 ID:SGTC_1736|Compound:st036774|FD-Score:-3.90|P-value:9.17E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.36|P-value:5.55E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.24|P-value:9.25E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.49|P-value:3.61E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.97|P-value:5.96E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-3.74|P-value:1.64E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.30|P-value:6.92E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.24|P-value:2.03E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.50|P-value:3.95E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.46|P-value:3.94E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.42|P-value:5.12E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.50|P-value:3.89E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.82|P-value:1.07E-4 ID:SGTC_2333|Compound:9017922|FD-Score:6.48|P-value:1.83E-10 ID:SGTC_2339|Compound:9000433|FD-Score:4.03|P-value:4.74E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.48|P-value:7.20E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.35|P-value:1.48E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.80|P-value:1.18E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.31|P-value:7.56E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.33|P-value:6.22E-4

Top fitness defect scores for YAR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1254 0550-0035 7.16 264.0 µM 2.17E-12 1 3.90E-13
2 SGTC_2333 9017922 6.48 200.0 µM 1.83E-10 3 4.52E-11
3 SGTC_1728 st035614 5.49 33.8 µM 5.44E-8 11 2.00E-8
4 SGTC_1259 0671-0132 5.12 43.0 µM 3.67E-7 5 1.54E-7
5 SGTC_475 α-linolenic acid 4.61 10.0 µM 4.05E-6 excess fatty acid 11 2.01E-6
6 SGTC_2352 9027995 4.48 87.8 µM 7.20E-6 tubulin folding & SWR complex 24 3.72E-6
7 SGTC_256 clotrimazole 4.34 625.0 nM 1.35E-5 ergosterol depletion effects on membrane 18 7.29E-6
8 SGTC_2066 5222451 4.24 176.0 µM 2.03E-5 heme biosynthesis & mitochondrial translocase 26 1.12E-5
9 SGTC_1282 0886-0010 4.10 32.4 µM 3.59E-5 endomembrane recycling 30 2.06E-5
10 SGTC_212 3807-4682 4.08 38.8 µM 3.93E-5 tubulin folding & SWR complex 65 2.28E-5
11 SGTC_2339 9000433 4.03 200.0 µM 4.74E-5 34 2.78E-5
12 SGTC_181 1447-1644 3.98 8.1 µM 5.83E-5 endomembrane recycling 35 3.47E-5
13 SGTC_2005 4024620 3.97 188.0 µM 5.96E-5 19 3.55E-5
14 SGTC_2300 7976697 3.82 71.6 µM 1.07E-4 ERG2 34 6.64E-5
15 SGTC_3203 9113543 3.80 49.5 µM 1.18E-4 35 7.33E-5
16 SGTC_2413 inermin 3.78 26.1 µM 1.27E-4 62 7.96E-5
17 SGTC_1430 4049-0248 3.50 69.1 µM 3.52E-4 30 2.36E-4
18 SGTC_1953 st076800 3.49 12.1 µM 3.61E-4 63 2.42E-4
19 SGTC_451 chloral hydrate 3.48 100.0 µM 3.73E-4 76 2.51E-4
20 SGTC_2131 toluylene red 3.46 5.3 µM 3.94E-4 60S ribosome export 39 2.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 3.00E-10 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.096 2.60E-8 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.093 6.06E-8 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.092 9.26E-8 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.092 1.03E-7 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.090 1.71E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.087 4.68E-7 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.087 4.84E-7 YAL005C SSA1 hom ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
0.085 8.55E-7 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
0.083 1.30E-6 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.082 1.85E-6 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
0.082 2.25E-6 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.081 2.99E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.080 3.06E-6 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.080 3.75E-6 YFL030W AGX1 hom Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases