YAR035W / YAT1

Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR035W / YAT1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.17|P-value:3.87E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.08|P-value:5.54E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.13|P-value:6.57E-6 ID:SGTC_57|Compound:miconazole|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.47|P-value:1.17E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.82|P-value:2.86E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.33|P-value:2.29E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.24E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.52|P-value:9.53E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.42|P-value:1.54E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.31|P-value:2.26E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.81|P-value:2.70E-5 ID:SGTC_447|Compound:ml7|FD-Score:3.13|P-value:4.47E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.68|P-value:5.30E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-2.98|P-value:8.40E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.08|P-value:5.38E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.64|P-value:4.37E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-2.94|P-value:9.65E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.42|P-value:1.42E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.61|P-value:7.19E-5 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:2.18E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.81|P-value:2.69E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.97|P-value:8.18E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.49|P-value:1.08E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.97|P-value:1.32E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.93|P-value:1.58E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.02|P-value:6.84E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.20|P-value:3.49E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.71|P-value:4.62E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.18|P-value:3.68E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.80|P-value:4.10E-10 ID:SGTC_3329|Compound:9141233|FD-Score:5.74|P-value:6.04E-10 ID:SGTC_2|Compound:0422-0095|FD-Score:3.17|P-value:3.87E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.08|P-value:5.54E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.13|P-value:6.57E-6 ID:SGTC_57|Compound:miconazole|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.47|P-value:1.17E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.82|P-value:2.86E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.33|P-value:2.29E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.31|P-value:2.24E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.52|P-value:9.53E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.42|P-value:1.54E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.31|P-value:2.26E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.81|P-value:2.70E-5 ID:SGTC_447|Compound:ml7|FD-Score:3.13|P-value:4.47E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.68|P-value:5.30E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-2.98|P-value:8.40E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.08|P-value:5.38E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.64|P-value:4.37E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.93|P-value:9.30E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-2.94|P-value:9.65E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.42|P-value:1.42E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.61|P-value:7.19E-5 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:2.18E-6 ID:SGTC_1734|Compound:st037168|FD-Score:3.81|P-value:2.69E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.97|P-value:8.18E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.49|P-value:1.08E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.97|P-value:1.32E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.93|P-value:1.58E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.02|P-value:6.84E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.20|P-value:3.49E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.02|P-value:6.76E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.71|P-value:4.62E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.18|P-value:3.68E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.80|P-value:4.10E-10 ID:SGTC_3329|Compound:9141233|FD-Score:5.74|P-value:6.04E-10

Top fitness defect scores for YAR035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2788 5282734 5.80 71.4 µM 4.10E-10 12 3.30E-9
2 SGTC_3329 9141233 5.74 27.6 µM 6.04E-10 2 4.66E-9
3 SGTC_970 1315-0089 4.64 19.5 µM 4.37E-7 RSC & ERG11 12 1.71E-6
4 SGTC_1120 ficusin 4.42 1.8 µM 1.42E-6 15 4.91E-6
5 SGTC_1611 st001856 4.34 99.4 µM 2.18E-6 11 7.24E-6
6 SGTC_2309 7664088 3.97 163.9 µM 1.32E-5 30 3.64E-5
7 SGTC_2313 7726885 3.93 200.0 µM 1.58E-5 RPP1 & pyrimidine depletion 34 4.27E-5
8 SGTC_1734 st037168 3.81 69.4 µM 2.69E-5 30 6.90E-5
9 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.81 6.7 µM 2.70E-5 14 6.93E-5
10 SGTC_165 k038-0023 3.52 64.4 µM 9.53E-5 ubiquinone biosynthesis & proteasome 104 2.15E-4
11 SGTC_2063 5246145 3.49 200.0 µM 1.08E-4 37 2.40E-4
12 SGTC_62 0180-0423 3.47 3.2 µM 1.17E-4 60S ribosome export 35 2.58E-4
13 SGTC_160 3453-0671 3.32 289.7 µM 2.14E-4 63 4.45E-4
14 SGTC_154 3389-1638 3.31 511.1 µM 2.24E-4 45 4.63E-4
15 SGTC_233 rapamycin 3.31 362.0 pM 2.26E-4 28 4.67E-4
16 SGTC_57 miconazole 3.25 162.5 nM 2.90E-4 ergosterol depletion effects on membrane 43 5.85E-4
17 SGTC_2420 aureobasidin a 3.20 50.0 nM 3.49E-4 77 6.91E-4
18 SGTC_2506 ethyl hematommate 3.18 54.2 µM 3.68E-4 RPP1 & pyrimidine depletion 43 7.25E-4
19 SGTC_2 0422-0095 3.17 29.0 µM 3.87E-4 redox potentiating 17 7.58E-4
20 SGTC_447 ml7 3.13 120.0 µM 4.47E-4 NEO1-PIK1 63 8.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.00E-11 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.115 2.43E-11 YCR001W_d YCR001W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
0.095 3.48E-8 YBL008W HIR1 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
0.094 4.66E-8 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.091 1.10E-7 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.090 1.76E-7 YKR084C HBS1 hom GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay
0.084 1.09E-6 YIR020W-A_d YIR020W-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.083 1.68E-6 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.082 2.15E-6 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.081 2.43E-6 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.080 3.10E-6 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.080 3.22E-6 YER137C_p YER137C_p hom Putative protein of unknown function
0.080 3.92E-6 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.078 5.31E-6 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.078 6.75E-6 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction