HIPHOP chemogenomics database

YBL004W / UTP20

Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA

Zygosity: Heterozygous strain

fixedexpanded
Profile for YBL004W / UTP20

Click on Significant Values for Screen Details

Top fitness defect scores for YBL004W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_617	3770-0098	17.30	35.0 µM	1.33E-68	exosome	1	2.10E-67	3.16
2	SGTC_2956	9076196	5.06	2.5 µM	1.78E-7		2	2.10E-7	0.83
3	SGTC_774	k060-0086	4.86	136.0 µM	5.15E-7		2	5.97E-7	0.56
4	SGTC_2363	9053361	4.81	176.0 µM	6.45E-7	Golgi	7	7.44E-7	0.25
5	SGTC_2366	9070441	4.78	60.6 µM	7.75E-7		4	8.92E-7	0.48
6	SGTC_324	1315-0088	4.42	19.6 µM	4.39E-6	RSC & ERG11	9	4.92E-6	0.20
7	SGTC_328	k915-0120	4.24	63.5 µM	1.01E-5	TSC3-RPN4	3	1.12E-5	0.52
8	SGTC_536	3852-0578	4.23	10.6 µM	1.07E-5		1	1.19E-5	0.50
9	SGTC_1721	st082152	4.21	9.3 µM	1.15E-5	60S ribosome export	7	1.27E-5	0.08
10	SGTC_1157	4092-0394	4.17	27.6 µM	1.39E-5		3	1.53E-5	0.45
11	SGTC_2949	9072542	4.14	2.2 µM	1.58E-5	TSC3-RPN4	13	1.74E-5	0.29
12	SGTC_2067	5224629	4.12	34.1 µM	1.75E-5		9	1.92E-5	0.03
13	SGTC_2754	granisetron	3.96	64.0 µM	3.44E-5		6	3.74E-5	0.10
14	SGTC_1266	0828-0227	3.88	32.9 µM	4.86E-5		12	5.25E-5	0.02
15	SGTC_3290	9121031	3.86	71.4 µM	5.29E-5		3	5.71E-5	0.38
16	SGTC_1911	st060208	3.79	74.3 µM	7.12E-5		10	7.65E-5	0.18
17	SGTC_2997	9067075	3.74	71.4 µM	8.75E-5	unfolded protein response	24	9.38E-5	0.06
18	SGTC_3330	9141424	3.73	71.4 µM	8.92E-5	amide catabolism	3	9.55E-5	0.13
19	SGTC_2963	9082507	3.71	9.0 µM	9.59E-5		10	1.03E-4	0.05
20	SGTC_3233	9132340	3.65	49.5 µM	1.25E-4		14	1.33E-4	0.11

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.228	1.09E-40	YIL083C	CAB2	het	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.225	8.85E-40	YOR159C	SME1	het	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.179	1.34E-25	YHR166C	CDC23	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.171	1.58E-23	YLR129W	DIP2	het	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.170	3.71E-23	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.170	4.15E-23	YML098W	TAF13	het	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.162	4.42E-21	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.155	1.74E-19	YNL161W	CBK1	het	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.153	5.14E-19	YNL140C_p	YNL140C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.153	6.05E-19	YGR090W	UTP22	het	Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.151	1.31E-18	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.149	3.16E-18	YIL147C	SLN1	het	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.147	1.13E-17	YDL060W	TSR1	het	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.143	6.66E-17	YER147C	SCC4	het	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.141	2.19E-16	YBL020W	RFT1	het	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein