YBL008W / HIR1

Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL008W / HIR1

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.24|P-value:1.85E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.22|P-value:8.05E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.42|P-value:3.97E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.27|P-value:7.54E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.15|P-value:9.96E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.17|P-value:9.38E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.21|P-value:2.07E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.14|P-value:2.78E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.36|P-value:1.12E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.49|P-value:3.10E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.43|P-value:4.29E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.36|P-value:5.41E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.72|P-value:2.15E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:6.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.73|P-value:2.12E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.62|P-value:1.97E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.69|P-value:1.50E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.43|P-value:4.32E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.96|P-value:5.92E-5 ID:SGTC_1995|Compound:st072814|FD-Score:5.13|P-value:3.02E-7 ID:SGTC_2196|Compound:6573537|FD-Score:-4.30|P-value:1.25E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.27|P-value:6.75E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.50|P-value:5.97E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.32|P-value:6.20E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.63|P-value:2.10E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.55|P-value:2.84E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.39|P-value:4.97E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.96|P-value:5.77E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.50|P-value:3.35E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.18|P-value:9.12E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.08|P-value:3.88E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.72|P-value:1.50E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.24|P-value:1.85E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.22|P-value:8.05E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.42|P-value:3.97E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.27|P-value:7.54E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:-3.15|P-value:9.96E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.17|P-value:9.38E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.21|P-value:2.07E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.14|P-value:2.78E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.36|P-value:1.12E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.49|P-value:3.10E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.43|P-value:4.29E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.36|P-value:5.41E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.72|P-value:2.15E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:6.59E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.73|P-value:2.12E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.66|P-value:1.88E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.62|P-value:1.97E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.69|P-value:1.50E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.43|P-value:4.32E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.96|P-value:5.92E-5 ID:SGTC_1995|Compound:st072814|FD-Score:5.13|P-value:3.02E-7 ID:SGTC_2196|Compound:6573537|FD-Score:-4.30|P-value:1.25E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.27|P-value:6.75E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.50|P-value:5.97E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.32|P-value:6.20E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.63|P-value:2.10E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.55|P-value:2.84E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.39|P-value:4.97E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.96|P-value:5.77E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.50|P-value:3.35E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.18|P-value:9.12E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.08|P-value:3.88E-7

Top fitness defect scores for YBL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1995 st072814 5.13 61.1 µM 3.02E-7 3 1.48E-7
2 SGTC_3329 9141233 5.08 27.6 µM 3.88E-7 5 1.92E-7
3 SGTC_1264 0783-0040 4.73 158.0 µM 2.12E-6 11 1.14E-6
4 SGTC_1256 0570-0116 4.72 285.0 µM 2.15E-6 6 1.16E-6
5 SGTC_2313 7726885 4.50 200.0 µM 5.97E-6 RPP1 & pyrimidine depletion 23 3.39E-6
6 SGTC_1221 2958-7315 4.36 257.0 µM 1.12E-5 15 6.59E-6
7 SGTC_241 5hr heat shock (37°C) + cantharidin 4.24 155.4 µM 1.85E-5 cell wall signaling 64 1.12E-5
8 SGTC_1157 4092-0394 4.21 27.6 µM 2.07E-5 24 1.25E-5
9 SGTC_2358 9037157 4.17 4.0 µM 2.51E-5 24 1.53E-5
10 SGTC_1219 1469-0211 4.14 33.1 µM 2.78E-5 18 1.71E-5
11 SGTC_1071 trifluoperazine 4.11 6.3 µM 3.21E-5 21 1.99E-5
12 SGTC_3206 9114350 3.96 49.5 µM 5.77E-5 20 3.68E-5
13 SGTC_1986 st071812 3.96 45.0 µM 5.92E-5 7 3.78E-5
14 SGTC_184 1494-0393 3.72 24.7 µM 1.50E-4 68 1.00E-4
15 SGTC_1378 2093-0007 3.66 380.0 nM 1.88E-4 27 1.27E-4
16 SGTC_115 0527-0192 3.66 112.0 µM 1.89E-4 89 1.28E-4
17 SGTC_2446 5162541 3.63 200.0 µM 2.10E-4 15 1.43E-4
18 SGTC_2961 9083290 3.55 32.5 µM 2.75E-4 30 1.90E-4
19 SGTC_2529 gangaleoidin 3.55 93.6 µM 2.84E-4 28 1.96E-4
20 SGTC_3222 9128301 3.50 49.5 µM 3.35E-4 60S ribosome export 39 2.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.67E-16 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.118 6.84E-12 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.115 2.86E-11 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.101 5.22E-9 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.095 3.48E-8 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.091 1.41E-7 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.090 1.62E-7 YCR082W AHC2 hom Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex
0.083 1.38E-6 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.082 1.88E-6 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.079 5.20E-6 YCL039W GID7 hom Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
0.078 6.13E-6 YGL076C RPL7A hom Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
0.077 8.45E-6 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.077 9.03E-6 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.070 4.70E-5 YDL168W SFA1 hom Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
0.069 6.15E-5 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate