YBL009W / ALK2

Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL009W / ALK2

Click on Significant Values for Screen Details ID:SGTC_122|Compound:0236-0016|FD-Score:3.78|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.51|P-value:8.60E-7 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.02|P-value:6.46E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.18|P-value:3.61E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.25|P-value:3.38E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.30|P-value:2.24E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.91|P-value:9.64E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.10|P-value:5.02E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.13|P-value:4.53E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.96|P-value:8.70E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:2.86E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.13|P-value:4.38E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.18|P-value:2.73E-11 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.31|P-value:2.11E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.95|P-value:8.97E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.14|P-value:4.42E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.61|P-value:6.44E-5 ID:SGTC_1548|Compound:st061468|FD-Score:-3.01|P-value:6.75E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.04|P-value:9.17E-6 ID:SGTC_1784|Compound:st039334|FD-Score:2.92|P-value:9.91E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.58|P-value:7.26E-5 ID:SGTC_1805|Compound:st050013|FD-Score:2.95|P-value:8.85E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.01|P-value:6.86E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.23|P-value:3.59E-6 ID:SGTC_2375|Compound:9072683|FD-Score:4.84|P-value:1.46E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.14|P-value:4.35E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.00|P-value:7.44E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-4.22|P-value:3.66E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.49|P-value:1.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.07|P-value:3.88E-8 ID:SGTC_3019|Compound:9081971|FD-Score:-3.90|P-value:1.66E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.77|P-value:2.15E-7 ID:SGTC_3275|Compound:9138069|FD-Score:-2.93|P-value:9.06E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.78|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.51|P-value:8.60E-7 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.02|P-value:6.46E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.18|P-value:3.61E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.25|P-value:3.38E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.30|P-value:2.24E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.91|P-value:9.64E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.10|P-value:5.02E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.13|P-value:4.53E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.96|P-value:8.70E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:2.86E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.13|P-value:4.38E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.18|P-value:2.73E-11 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.31|P-value:2.11E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.95|P-value:8.97E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.14|P-value:4.42E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.61|P-value:6.44E-5 ID:SGTC_1548|Compound:st061468|FD-Score:-3.01|P-value:6.75E-4 ID:SGTC_1637|Compound:st007924|FD-Score:4.04|P-value:9.17E-6 ID:SGTC_1784|Compound:st039334|FD-Score:2.92|P-value:9.91E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.58|P-value:7.26E-5 ID:SGTC_1805|Compound:st050013|FD-Score:2.95|P-value:8.85E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.01|P-value:6.86E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.23|P-value:3.59E-6 ID:SGTC_2375|Compound:9072683|FD-Score:4.84|P-value:1.46E-7 ID:SGTC_2387|Compound:9077560|FD-Score:3.14|P-value:4.35E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.00|P-value:7.44E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-4.22|P-value:3.66E-6 ID:SGTC_2450|Compound:5739737|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.49|P-value:1.10E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:5.07|P-value:3.88E-8 ID:SGTC_3019|Compound:9081971|FD-Score:-3.90|P-value:1.66E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.77|P-value:2.15E-7 ID:SGTC_3275|Compound:9138069|FD-Score:-2.93|P-value:9.06E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.24|P-value:3.00E-4

Top fitness defect scores for YBL009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 6.18 265.0 µM 2.73E-11 9 3.15E-10
2 SGTC_2638 epoxomicin 5.07 18.0 µM 3.88E-8 10 2.03E-7
3 SGTC_2375 9072683 4.84 200.0 µM 1.46E-7 mitochondrial processes 8 6.59E-7
4 SGTC_3205 9113483 4.77 49.5 µM 2.15E-7 10 9.34E-7
5 SGTC_194 1486-1323 4.51 56.9 µM 8.60E-7 10 3.21E-6
6 SGTC_421 streptovitacin 4.25 30.0 mM 3.38E-6 15 1.09E-5
7 SGTC_2238 6671620 4.23 73.2 µM 3.59E-6 22 1.15E-5
8 SGTC_1637 st007924 4.04 17.4 µM 9.17E-6 18 2.66E-5
9 SGTC_122 0236-0016 3.78 402.4 µM 3.09E-5 RNA processing & uracil transport 37 7.87E-5
10 SGTC_1535 tetrahydropapaveroline hydrobromide 3.61 54.3 µM 6.44E-5 RPP1 & pyrimidine depletion 19 1.52E-4
11 SGTC_1804 st050076 3.58 49.1 µM 7.26E-5 24 1.69E-4
12 SGTC_2628 lathosterol 3.49 100.0 µM 1.10E-4 43 2.45E-4
13 SGTC_1455 4262-0120 3.42 131.0 µM 1.46E-4 plasma membrane duress 44 3.16E-4
14 SGTC_1248 0469-0687 3.34 58.6 µM 1.99E-4 53 4.17E-4
15 SGTC_1203 3992-3522 3.25 103.0 µM 2.86E-4 71 5.76E-4
16 SGTC_3341 9147222 3.24 25.9 µM 3.00E-4 RNA processing & uracil transport 37 6.00E-4
17 SGTC_2387 9077560 3.14 195.1 µM 4.35E-4 48 8.37E-4
18 SGTC_2450 5739737 3.14 12.9 µM 4.37E-4 58 8.41E-4
19 SGTC_1442 4112-3290 3.14 3.0 µM 4.42E-4 39 8.51E-4
20 SGTC_887 0885-0007 3.13 9.6 µM 4.53E-4 endomembrane recycling 70 8.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 5.72E-33 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.151 1.81E-18 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.123 9.99E-13 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.112 7.51E-11 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.109 2.06E-10 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.107 4.97E-10 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.106 7.53E-10 YPR108W-A_p YPR108W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.105 1.27E-9 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.104 1.69E-9 YGR243W FMP43 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress
0.102 2.66E-9 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.099 7.69E-9 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.099 1.04E-8 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.098 1.16E-8 YNL266W_d YNL266W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C
0.097 1.97E-8 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.096 2.46E-8 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source