YBL013W / FMT1

Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL013W / FMT1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.32|P-value:9.18E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.12|P-value:5.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.04|P-value:7.15E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.06|P-value:8.67E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.41|P-value:6.83E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.33|P-value:5.38E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:5.12|P-value:6.27E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.47|P-value:5.59E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.61|P-value:3.47E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.90|P-value:1.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.48|P-value:5.35E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.18|P-value:9.09E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.84|P-value:1.51E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.30|P-value:2.53E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.32|P-value:9.25E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.33|P-value:2.22E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.35|P-value:5.03E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.86|P-value:1.41E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.72|P-value:2.09E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.86|P-value:7.92E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.57|P-value:2.32E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.58|P-value:2.30E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.82|P-value:4.69E-11 ID:SGTC_2001|Compound:4023502|FD-Score:-4.70|P-value:2.27E-6 ID:SGTC_2002|Compound:4023503|FD-Score:7.51|P-value:4.72E-13 ID:SGTC_2007|Compound:4011539|FD-Score:-3.48|P-value:3.24E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.65|P-value:5.59E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.54|P-value:2.75E-10 ID:SGTC_2425|Compound:5628681|FD-Score:-5.88|P-value:5.65E-9 ID:SGTC_2436|Compound:5633522|FD-Score:-3.82|P-value:9.14E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.28|P-value:2.75E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.12|P-value:5.23E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.66|P-value:2.80E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.53|P-value:9.36E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.07|P-value:8.33E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:-10.10|P-value:8.47E-23 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.69|P-value:1.51E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.58|P-value:2.27E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.62|P-value:3.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.35|P-value:5.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:5.45|P-value:1.27E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-5.71|P-value:1.39E-8 ID:SGTC_3326|Compound:9140064|FD-Score:3.33|P-value:8.82E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.32|P-value:9.18E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.12|P-value:5.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.04|P-value:7.15E-5 ID:SGTC_264|Compound:promethazine|FD-Score:5.06|P-value:8.67E-7 ID:SGTC_277|Compound:nystatin|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.41|P-value:6.83E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.33|P-value:5.38E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:5.12|P-value:6.27E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.47|P-value:5.59E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.61|P-value:3.47E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.90|P-value:1.20E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.48|P-value:5.35E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.18|P-value:9.09E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.84|P-value:1.51E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.30|P-value:2.53E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.32|P-value:9.25E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.33|P-value:2.22E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:-3.35|P-value:5.03E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.86|P-value:1.41E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.67|P-value:1.62E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.72|P-value:2.09E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.86|P-value:7.92E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.57|P-value:2.32E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.58|P-value:2.30E-4 ID:SGTC_1934|Compound:st074720|FD-Score:6.82|P-value:4.69E-11 ID:SGTC_2001|Compound:4023502|FD-Score:-4.70|P-value:2.27E-6 ID:SGTC_2002|Compound:4023503|FD-Score:7.51|P-value:4.72E-13 ID:SGTC_2007|Compound:4011539|FD-Score:-3.48|P-value:3.24E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.65|P-value:5.59E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.59|P-value:2.15E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.54|P-value:2.75E-10 ID:SGTC_2425|Compound:5628681|FD-Score:-5.88|P-value:5.65E-9 ID:SGTC_2436|Compound:5633522|FD-Score:-3.82|P-value:9.14E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:3.58|P-value:3.88E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.28|P-value:2.75E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.12|P-value:5.23E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.66|P-value:2.80E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.53|P-value:9.36E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:5.07|P-value:8.33E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:-10.10|P-value:8.47E-23 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.69|P-value:1.51E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.58|P-value:2.27E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.62|P-value:3.34E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.35|P-value:5.03E-4 ID:SGTC_3218|Compound:9131285|FD-Score:5.45|P-value:1.27E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-5.71|P-value:1.39E-8 ID:SGTC_3326|Compound:9140064|FD-Score:3.33|P-value:8.82E-4

Top fitness defect scores for YBL013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 7.51 131.0 µM 4.72E-13 mitochondrial processes 4 2.90E-14
2 SGTC_1934 st074720 6.82 32.6 µM 4.69E-11 12 4.46E-12
3 SGTC_2348 9022543 6.54 33.4 µM 2.75E-10 mitochondrial processes 4 3.10E-11
4 SGTC_3218 9131285 5.45 49.5 µM 1.27E-7 endomembrane recycling 11 2.57E-8
5 SGTC_336 4111-0029 5.12 111.0 µM 6.27E-7 3 1.49E-7
6 SGTC_2614 arthonioic acid 5.07 13.4 µM 8.33E-7 7 2.04E-7
7 SGTC_264 promethazine 5.06 12.5 mM 8.67E-7 DNA intercalators 29 2.13E-7
8 SGTC_1094 duloxetine 4.93 25.4 µM 1.58E-6 RPP1 & pyrimidine depletion 3 4.12E-7
9 SGTC_2128 5255449 4.65 168.5 µM 5.59E-6 19 1.65E-6
10 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.53 70.0 µM 9.36E-6 redox potentiating 58 2.90E-6
11 SGTC_1393 3470-5649 4.33 58.2 µM 2.22E-5 60S ribosome export 9 7.50E-6
12 SGTC_1244 0416-0015 4.30 52.5 µM 2.53E-5 ERG2 25 8.66E-6
13 SGTC_2570 licareol 4.28 100.0 µM 2.75E-5 21 9.47E-6
14 SGTC_2571 chrysanthemic acid 4.12 100.0 µM 5.23E-5 13 1.92E-5
15 SGTC_135 0933-0004 4.12 26.4 µM 5.25E-5 60S ribosome export 19 1.93E-5
16 SGTC_181 1447-1644 4.04 8.1 µM 7.15E-5 endomembrane recycling 33 2.71E-5
17 SGTC_804 1595-0054 3.90 20.9 µM 1.20E-4 sphingolipid biosynthesis & PDR1 36 4.78E-5
18 SGTC_1455 4262-0120 3.86 131.0 µM 1.41E-4 plasma membrane duress 24 5.73E-5
19 SGTC_1195 1502-0147 3.84 41.1 µM 1.51E-4 31 6.15E-5
20 SGTC_2894 9048625 3.62 32.5 µM 3.34E-4 20 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 2.94E-34 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.176 8.30E-25 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.130 3.42E-14 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.121 2.41E-12 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
0.120 3.59E-12 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.105 1.26E-9 YOR054C VHS3 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.102 3.16E-9 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.102 3.57E-9 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.094 4.30E-8 YHL047C ARN2 hom Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
0.093 8.36E-8 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.092 1.08E-7 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.091 1.21E-7 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.083 1.37E-6 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.083 1.50E-6 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.083 1.73E-6 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication