YBL019W / APN2

Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL019W / APN2

Click on Significant Values for Screen Details ID:SGTC_337|Compound:1315-0038|FD-Score:-3.08|P-value:1.68E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.34|P-value:5.99E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.69|P-value:1.07E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:2.70|P-value:9.41E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.13|P-value:1.35E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.95|P-value:2.93E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.08|P-value:1.72E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.85|P-value:5.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.94|P-value:3.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.69|P-value:8.58E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.72|P-value:7.66E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.86|P-value:3.63E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:2.76|P-value:7.52E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.44|P-value:1.51E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.73|P-value:7.34E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.83|P-value:4.81E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.09|P-value:1.24E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.90|P-value:4.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.68|P-value:9.34E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.75|P-value:6.78E-4 ID:SGTC_1594|Compound:piperine|FD-Score:2.70|P-value:9.62E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.86|P-value:4.36E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.60|P-value:1.69E-5 ID:SGTC_2014|Compound:4013930|FD-Score:2.71|P-value:9.28E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.77|P-value:7.09E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.84|P-value:4.01E-6 ID:SGTC_2353|Compound:9059630|FD-Score:2.84|P-value:5.50E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_2371|Compound:9071574|FD-Score:2.98|P-value:3.03E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.43|P-value:3.95E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.70|P-value:9.68E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.79|P-value:5.11E-6 ID:SGTC_2381|Compound:9035592|FD-Score:2.91|P-value:4.06E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.56|P-value:1.78E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.76|P-value:6.48E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.98|P-value:3.08E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.94|P-value:2.82E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.01|P-value:2.63E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.74|P-value:8.13E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.23|P-value:1.03E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.77|P-value:7.18E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.08|P-value:1.68E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.34|P-value:5.99E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.69|P-value:1.07E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:2.70|P-value:9.41E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.13|P-value:1.35E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.95|P-value:2.93E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.08|P-value:1.72E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.85|P-value:5.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.94|P-value:3.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.69|P-value:8.58E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.72|P-value:7.66E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.86|P-value:3.63E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:2.76|P-value:7.52E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.44|P-value:1.51E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:-2.73|P-value:7.34E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.83|P-value:4.81E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.09|P-value:1.24E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.90|P-value:4.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.68|P-value:9.34E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.75|P-value:6.78E-4 ID:SGTC_1594|Compound:piperine|FD-Score:2.70|P-value:9.62E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.86|P-value:4.36E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.60|P-value:1.69E-5 ID:SGTC_2014|Compound:4013930|FD-Score:2.71|P-value:9.28E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.77|P-value:7.09E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.84|P-value:4.01E-6 ID:SGTC_2353|Compound:9059630|FD-Score:2.84|P-value:5.50E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.11|P-value:1.70E-4 ID:SGTC_2371|Compound:9071574|FD-Score:2.98|P-value:3.03E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.43|P-value:3.95E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.70|P-value:9.68E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.79|P-value:5.11E-6 ID:SGTC_2381|Compound:9035592|FD-Score:2.91|P-value:4.06E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.56|P-value:1.78E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.76|P-value:6.48E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.98|P-value:3.08E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.94|P-value:2.82E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.01|P-value:2.63E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.74|P-value:8.13E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.23|P-value:1.03E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.77|P-value:7.18E-4

Top fitness defect scores for YBL019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_934 2950-0684 4.44 338.0 µM 1.51E-7 13 4.43E-6
2 SGTC_1174 0739-0097 4.09 51.1 µM 1.24E-6 redox potentiating 29 2.19E-5
3 SGTC_2605 digitonin 3.94 300.0 nM 2.82E-6 30 4.07E-5
4 SGTC_374 0880-0231 3.69 82.3 µM 1.07E-5 iron homeostasis 26 1.12E-4
5 SGTC_1976 st070609 3.60 63.5 µM 1.69E-5 17 1.59E-4
6 SGTC_2372 9071633 3.43 200.0 µM 3.95E-5 23 3.03E-4
7 SGTC_358 0075-0058 3.34 9.4 µM 5.99E-5 99 4.17E-4
8 SGTC_2794 7785382 3.23 27.3 µM 1.03E-4 70 6.29E-4
9 SGTC_2354 9060492 3.11 162.0 µM 1.70E-4 56 9.25E-4
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.01 100.0 µM 2.63E-4 73 0.00129
11 SGTC_2371 9071574 2.98 200.0 µM 3.03E-4 43 0.00144
12 SGTC_2585 alliin 2.98 100.0 µM 3.08E-4 81 0.00146
13 SGTC_686 1319-0111 2.94 510.0 µM 3.54E-4 60S ribosome export 70 0.00162
14 SGTC_2381 9035592 2.91 200.0 µM 4.06E-4 63 0.00180
15 SGTC_1177 0983-0204 2.90 23.6 µM 4.34E-4 57 0.00190
16 SGTC_669 0108-0021 2.85 26.2 µM 5.18E-4 fatty acid desaturase (OLE1) 164 0.00217
17 SGTC_2353 9059630 2.84 146.7 µM 5.50E-4 50 0.00227
18 SGTC_2254 7938975 2.77 95.2 µM 7.09E-4 121 0.00276
19 SGTC_2799 7812892 2.77 81.8 µM 7.18E-4 superoxide 95 0.00279
20 SGTC_932 2857-0803 2.76 154.0 µM 7.52E-4 84 0.00289

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.20E-40 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.192 3.30E-29 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.186 1.36E-27 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.176 1.15E-24 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.174 2.69E-24 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.165 6.49E-22 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.160 1.57E-20 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.149 4.94E-18 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.144 4.76E-17 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.142 1.57E-16 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.140 5.02E-16 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.139 5.51E-16 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.139 7.09E-16 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.136 2.71E-15 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.134 7.30E-15 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p