HIPHOP chemogenomics database

YBL036C

Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain

fixedexpanded
Profile for YBL036C / YBL036C

Click on Significant Values for Screen Details

Top fitness defect scores for YBL036C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1630	st005209	3.46	31.3 µM	5.26E-5		41	2.74E-4
2	SGTC_2602	kawain	3.29	100.0 µM	1.08E-4		53	4.93E-4
3	SGTC_2794	7785382	3.07	27.3 µM	2.83E-4		87	0.00108
4	SGTC_1251	0490-5699	3.06	265.0 µM	2.88E-4		80	0.00110
5	SGTC_2692	st077426	3.00	47.7 µM	3.76E-4		68	0.00137
6	SGTC_3297	9117502	2.98	71.4 µM	4.09E-4		36	0.00146
7	SGTC_1587	estradiol valerate	2.95	56.1 µM	4.55E-4		44	0.00160
8	SGTC_2160	5660466	2.92	132.9 µM	5.02E-4	60S ribosome export	53	0.00173
9	SGTC_2103	5378138	2.84	10.0 µM	6.86E-4		71	0.00223
10	SGTC_189	3970-0742	2.77	2.1 µM	9.12E-4		40	0.00282
11	SGTC_366	0181-0206	2.70	4.3 µM	0.00118	Golgi	126	0.00348
12	SGTC_606	k015-0008	2.67	38.6 µM	0.00131		90	0.00378
13	SGTC_2791	5663188	2.64	71.4 µM	0.00148	RPP1 & pyrimidine depletion	97	0.00420
14	SGTC_73	0327-0325	2.61	16.2 µM	0.00161	DNA damage response	169	0.00450
15	SGTC_2493	resveratrol	2.59	26.1 µM	0.00175		65	0.00480
16	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	2.56	3.7 µM	0.00195		296	0.00525
17	SGTC_381	3461-2219	2.51	42.7 µM	0.00228	copper-dependent oxidative stress	102	0.00597
18	SGTC_3018	9082602	2.50	49.5 µM	0.00240		124	0.00623
19	SGTC_186	3455-3465	2.49	67.3 µM	0.00247		36	0.00638
20	SGTC_1988	st071872	2.49	53.4 µM	0.00249		94	0.00641

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.423	1.66E-145	YOL141W	PPM2	hom	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.371	5.42E-110	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.354	1.76E-99	YLL012W	YEH1	hom	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.344	8.89E-94	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.342	1.60E-92	YKL220C	FRE2	hom	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.338	2.23E-90	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.328	4.84E-85	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.323	1.69E-82	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.318	1.01E-79	YAL045C_d	YAL045C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.317	2.07E-79	YML083C	YML083C	hom	Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.313	3.74E-77	YGL081W_p	YGL081W_p	hom	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.312	6.66E-77	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.312	1.50E-76	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.284	3.75E-63	YER060W-A	FCY22	hom	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.282	1.86E-62	YMR095C	SNO1	hom	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase