YBL045C / COR1

Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL045C / COR1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.24|P-value:7.49E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.98|P-value:4.80E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.84|P-value:8.45E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.43|P-value:3.81E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.03|P-value:3.85E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.27|P-value:6.57E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-5.26|P-value:1.30E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.21|P-value:8.06E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.88|P-value:6.99E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.89|P-value:6.79E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.68|P-value:1.55E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.40|P-value:8.23E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.90|P-value:6.60E-5 ID:SGTC_1768|Compound:st044301|FD-Score:-3.22|P-value:7.82E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.47|P-value:3.32E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.16|P-value:9.50E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.24|P-value:7.49E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.98|P-value:4.80E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.84|P-value:8.45E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.43|P-value:3.81E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.03|P-value:3.85E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.27|P-value:6.57E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-5.26|P-value:1.30E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.21|P-value:8.06E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.88|P-value:6.99E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.89|P-value:6.79E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.68|P-value:1.55E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.40|P-value:8.23E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.90|P-value:6.60E-5 ID:SGTC_1768|Compound:st044301|FD-Score:-3.22|P-value:7.82E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.47|P-value:3.32E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.16|P-value:9.50E-4

Top fitness defect scores for YBL045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_271 rotenone 2.67 740.0 µM 0.00487 108 0.00382
2 SGTC_3173 9105693 2.61 49.5 µM 0.00576 109 0.00456
3 SGTC_3075 9116269 2.39 49.5 µM 0.01030 114 0.00842
4 SGTC_1389 3405-0187 2.37 19.0 µM 0.01100 128 0.00901
5 SGTC_173 1273-0061 2.35 2.7 µM 0.01150 mitochondrial stress 300 0.00943
6 SGTC_2730 imipramine 2.35 71.3 µM 0.01150 180 0.00945
7 SGTC_276 colchicine 2.34 750.0 µM 0.01170 139 0.00964
8 SGTC_3181 9108277 2.32 49.5 µM 0.01230 iron homeostasis 133 0.01010
9 SGTC_1856 st057054 2.27 55.7 µM 0.01410 147 0.01170
10 SGTC_2636 apigenin dimethyl ether 2.24 100.0 µM 0.01490 206 0.01240
11 SGTC_2385 9074692 2.24 200.0 µM 0.01500 183 0.01250
12 SGTC_2702 st077768 2.24 96.8 µM 0.01500 152 0.01250
13 SGTC_616 4092-0450 2.24 108.0 µM 0.01510 169 0.01250
14 SGTC_2087 5276107 2.23 200.0 µM 0.01560 142 0.01300
15 SGTC_1921 5740136 2.21 50.0 µM 0.01600 TRP & mitochondrial translation 234 0.01340
16 SGTC_2402 5553605 2.21 200.0 µM 0.01620 182 0.01350
17 SGTC_22 0964-0034 2.21 14.5 µM 0.01620 unfolded protein response 212 0.01350
18 SGTC_1574 spiramycin 2.20 23.7 µM 0.01680 190 0.01400
19 SGTC_3222 9128301 2.19 49.5 µM 0.01700 60S ribosome export 165 0.01430
20 SGTC_583 1488-1091 2.18 88.9 µM 0.01740 208 0.01460

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.92E-11 YCL027W FUS1 hom Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
0.094 4.39E-8 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.087 4.30E-7 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.085 8.47E-7 YNL080C EOS1 hom Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
0.085 9.13E-7 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.072 3.29E-5 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.071 3.58E-5 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.069 6.63E-5 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.066 1.18E-4 YGR169C-A_p YGR169C-A_p hom Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication
0.066 1.24E-4 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.064 1.89E-4 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.064 2.09E-4 YHL025W SNF6 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions
0.063 2.67E-4 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.062 3.08E-4 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.062 3.15E-4 YDR300C PRO1 hom Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication