YBL056W / PTC3

Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL056W / PTC3

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.27|P-value:5.96E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.43|P-value:2.21E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.02|P-value:8.88E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.49|P-value:1.79E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.37|P-value:2.48E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.72|P-value:5.51E-7 ID:SGTC_512|Compound:prima-1|FD-Score:4.17|P-value:8.32E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.76|P-value:4.44E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:3.26|P-value:3.70E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:5.32|P-value:2.03E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:4.38|P-value:3.03E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.62|P-value:1.01E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.86|P-value:3.11E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.96|P-value:2.13E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.30|P-value:3.16E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.96|P-value:1.47E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.06|P-value:1.36E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.60|P-value:1.01E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.98|P-value:2.23E-5 ID:SGTC_2151|Compound:5563267|FD-Score:4.00|P-value:1.80E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.13|P-value:6.07E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.27|P-value:3.95E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.16|P-value:5.96E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_2302|Compound:7771753|FD-Score:6.85|P-value:7.54E-13 ID:SGTC_2340|Compound:7987427|FD-Score:3.78|P-value:4.69E-5 ID:SGTC_2350|Compound:9023895|FD-Score:4.35|P-value:3.51E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.47|P-value:1.63E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.65|P-value:8.14E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.69|P-value:6.73E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.37|P-value:2.41E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.07|P-value:8.30E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:2.99|P-value:9.99E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.70|P-value:6.42E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.12|P-value:6.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-6.71|P-value:2.71E-12 ID:SGTC_2812|Compound:7970281|FD-Score:3.60|P-value:9.78E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-3.97|P-value:2.33E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.87|P-value:3.14E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.47|P-value:1.67E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.01|P-value:9.34E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.37|P-value:2.46E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.23|P-value:4.14E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.27|P-value:5.96E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.43|P-value:2.21E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.02|P-value:8.88E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.49|P-value:1.79E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.37|P-value:2.48E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.72|P-value:5.51E-7 ID:SGTC_512|Compound:prima-1|FD-Score:4.17|P-value:8.32E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.76|P-value:4.44E-7 ID:SGTC_646|Compound:4092-0839|FD-Score:3.26|P-value:3.70E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:5.32|P-value:2.03E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:4.38|P-value:3.03E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.42|P-value:2.02E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.12|P-value:7.05E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:-3.62|P-value:1.01E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.86|P-value:3.11E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.96|P-value:2.13E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.30|P-value:3.16E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.96|P-value:1.47E-7 ID:SGTC_1936|Compound:st074407|FD-Score:4.06|P-value:1.36E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.60|P-value:1.01E-6 ID:SGTC_2079|Compound:5212404|FD-Score:-3.98|P-value:2.23E-5 ID:SGTC_2151|Compound:5563267|FD-Score:4.00|P-value:1.80E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.13|P-value:6.07E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.27|P-value:3.95E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.16|P-value:5.96E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_2302|Compound:7771753|FD-Score:6.85|P-value:7.54E-13 ID:SGTC_2340|Compound:7987427|FD-Score:3.78|P-value:4.69E-5 ID:SGTC_2350|Compound:9023895|FD-Score:4.35|P-value:3.51E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.47|P-value:1.63E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.65|P-value:8.14E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.69|P-value:6.73E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.37|P-value:2.41E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.07|P-value:8.30E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.34|P-value:3.13E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:2.99|P-value:9.99E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.70|P-value:6.42E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.55|P-value:1.38E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.31|P-value:3.12E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.12|P-value:6.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-6.71|P-value:2.71E-12 ID:SGTC_2812|Compound:7970281|FD-Score:3.60|P-value:9.78E-5 ID:SGTC_2814|Compound:7977482|FD-Score:-3.97|P-value:2.33E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.87|P-value:3.14E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.47|P-value:1.67E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.01|P-value:9.34E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.37|P-value:2.46E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.23|P-value:4.14E-4

Top fitness defect scores for YBL056W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2302 7771753 6.85 200.0 µM 7.54E-13 4 3.57E-12
2 SGTC_729 4092-0585 5.32 94.1 µM 2.03E-8 7 5.32E-8
3 SGTC_1908 st060353 4.96 56.5 µM 1.47E-7 RPP1 & pyrimidine depletion 21 3.44E-7
4 SGTC_588 3970-1144 4.76 52.9 µM 4.44E-7 14 9.75E-7
5 SGTC_506 n9-isopropylolomoucine 4.72 153.0 µM 5.51E-7 6 1.20E-6
6 SGTC_2064 5220758 4.60 200.0 µM 1.01E-6 16 2.11E-6
7 SGTC_359 0081-0058 4.49 15.9 µM 1.79E-6 60S ribosome export 27 3.62E-6
8 SGTC_823 0417-1665 4.38 178.0 µM 3.03E-6 32 5.96E-6
9 SGTC_2350 9023895 4.35 38.9 µM 3.51E-6 ergosterol biosynthesis 21 6.85E-6
10 SGTC_512 prima-1 4.17 270.0 µM 8.32E-6 DNA intercalators 21 1.54E-5
11 SGTC_1936 st074407 4.06 74.3 µM 1.36E-5 DNA damage response 33 2.46E-5
12 SGTC_2151 5563267 4.00 85.4 µM 1.80E-5 19 3.20E-5
13 SGTC_1528 arabinosylhypoxanthine 3.96 74.6 µM 2.13E-5 18 3.75E-5
14 SGTC_2828 7998861 3.87 71.4 µM 3.14E-5 18 5.41E-5
15 SGTC_2340 7987427 3.78 183.4 µM 4.69E-5 41 7.89E-5
16 SGTC_2708 st078559 3.70 56.0 µM 6.42E-5 9 1.06E-4
17 SGTC_2469 5655019 3.69 90.8 µM 6.73E-5 26 1.11E-4
18 SGTC_2269 7935389 3.67 174.4 µM 7.36E-5 tubulin folding & SWR complex 35 1.21E-4
19 SGTC_2407 paclitaxel 3.65 400.0 µM 8.14E-5 48 1.33E-4
20 SGTC_2812 7970281 3.60 58.4 µM 9.78E-5 45 1.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.57E-10 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.108 3.76E-10 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.091 1.15E-7 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.086 6.07E-7 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.085 7.69E-7 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.084 1.17E-6 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.083 1.40E-6 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.082 2.12E-6 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.081 2.57E-6 YML030W RCF1 hom Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
0.080 3.12E-6 YGL197W MDS3 hom Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
0.080 3.67E-6 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.079 5.13E-6 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.078 6.16E-6 YMR078C CTF18 hom Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
0.078 6.26E-6 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.076 9.70E-6 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p