YBL066C / SEF1

Putative transcription factor, has homolog in Kluyveromyces lactis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL066C / SEF1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:2.92|P-value:7.69E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.96|P-value:6.67E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.45|P-value:1.44E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.23|P-value:3.47E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.45|P-value:2.24E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:3.39|P-value:1.22E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.86|P-value:9.54E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.91|P-value:9.77E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.01|P-value:1.00E-10 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.15|P-value:3.15E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.18|P-value:1.22E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.30|P-value:2.86E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.67|P-value:3.58E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.47|P-value:6.96E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.95|P-value:6.92E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.45|P-value:9.33E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.25|P-value:3.22E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.28|P-value:1.94E-6 ID:SGTC_2097|Compound:5376186|FD-Score:3.74|P-value:2.56E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.95|P-value:7.78E-11 ID:SGTC_2239|Compound:6685329|FD-Score:4.09|P-value:4.86E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.30|P-value:1.72E-6 ID:SGTC_2262|Compound:9014885|FD-Score:3.80|P-value:2.00E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.05|P-value:4.75E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.14|P-value:4.89E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.66|P-value:3.77E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.46|P-value:1.27E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-2.96|P-value:9.38E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.33E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.11|P-value:5.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.29|P-value:2.71E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.67|P-value:3.52E-5 ID:SGTC_2693|Compound:st077581|FD-Score:8.22|P-value:5.60E-19 ID:SGTC_2794|Compound:7785382|FD-Score:3.31|P-value:1.66E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.37|P-value:1.97E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.35|P-value:2.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.01|P-value:5.50E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.92|P-value:7.71E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.40|P-value:1.14E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:2.92|P-value:7.69E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:2.96|P-value:6.67E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.15|P-value:3.21E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.45|P-value:1.44E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.23|P-value:3.47E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.45|P-value:2.24E-9 ID:SGTC_798|Compound:1287-0182|FD-Score:3.39|P-value:1.22E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.86|P-value:9.45E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.86|P-value:9.54E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.91|P-value:9.77E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.01|P-value:1.00E-10 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.15|P-value:3.15E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.18|P-value:1.22E-8 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.30|P-value:2.86E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.67|P-value:3.58E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.47|P-value:6.96E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.95|P-value:6.92E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.45|P-value:9.33E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.25|P-value:3.22E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.23|P-value:2.36E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.28|P-value:1.94E-6 ID:SGTC_2097|Compound:5376186|FD-Score:3.74|P-value:2.56E-5 ID:SGTC_2103|Compound:5378138|FD-Score:5.95|P-value:7.78E-11 ID:SGTC_2239|Compound:6685329|FD-Score:4.09|P-value:4.86E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.30|P-value:1.72E-6 ID:SGTC_2262|Compound:9014885|FD-Score:3.80|P-value:2.00E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.05|P-value:4.75E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.14|P-value:4.89E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.66|P-value:3.77E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.46|P-value:1.27E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-2.96|P-value:9.38E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.33E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:1.23E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.11|P-value:5.37E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.29|P-value:2.71E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.67|P-value:3.52E-5 ID:SGTC_2693|Compound:st077581|FD-Score:8.22|P-value:5.60E-19 ID:SGTC_2794|Compound:7785382|FD-Score:3.31|P-value:1.66E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.37|P-value:1.97E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.35|P-value:2.12E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.01|P-value:5.50E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.92|P-value:7.71E-4

Top fitness defect scores for YBL066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2693 st077581 8.22 40.7 µM 5.60E-19 1 1.05E-16
2 SGTC_2103 5378138 5.95 10.0 µM 7.78E-11 2 1.37E-9
3 SGTC_1083 didemethylchlorpromazine sulfoxide 5.91 707.4 nM 9.77E-11 redox potentiating 27 1.68E-9
4 SGTC_669 0108-0021 5.45 26.2 µM 2.24E-9 fatty acid desaturase (OLE1) 28 2.58E-8
5 SGTC_1257 0669-0121 5.18 16.0 µM 1.22E-8 9 1.13E-7
6 SGTC_1262 0737-0114 4.47 49.6 µM 6.96E-7 11 3.88E-6
7 SGTC_2250 alverine citrate 4.30 130.0 µM 1.72E-6 133 8.54E-6
8 SGTC_2093 5331342 4.28 194.4 µM 1.94E-6 25 9.50E-6
9 SGTC_2239 6685329 4.09 187.6 µM 4.86E-6 24 2.12E-5
10 SGTC_2262 9014885 3.80 67.5 µM 2.00E-5 4 7.27E-5
11 SGTC_2097 5376186 3.74 200.0 µM 2.56E-5 26 9.04E-5
12 SGTC_2975 9084847 3.72 53.7 µM 2.84E-5 28 9.88E-5
13 SGTC_2692 st077426 3.67 47.7 µM 3.52E-5 28 1.19E-4
14 SGTC_1261 0712-0010 3.67 12.7 µM 3.58E-5 RNA processing & uracil transport 29 1.21E-4
15 SGTC_2407 paclitaxel 3.66 400.0 µM 3.77E-5 47 1.27E-4
16 SGTC_1563 conessine 3.45 56.1 µM 9.33E-5 31 2.79E-4
17 SGTC_155 k072-0202 3.40 43.6 µM 1.14E-4 30 3.33E-4
18 SGTC_798 1287-0182 3.39 476.0 µM 1.22E-4 44 3.54E-4
19 SGTC_2625 euphol 3.39 100.0 µM 1.23E-4 56 3.56E-4
20 SGTC_2794 7785382 3.31 27.3 µM 1.66E-4 64 4.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 1.89E-51 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.246 2.71E-47 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.244 1.38E-46 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.239 1.13E-44 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.228 1.02E-40 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.224 2.80E-39 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.213 7.54E-36 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.213 9.15E-36 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.207 1.10E-33 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.206 1.95E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.200 1.25E-31 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.197 1.46E-30 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.194 8.25E-30 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.193 2.30E-29 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.191 6.62E-29 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres