YBL081W_p

Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL081W / YBL081W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.87|P-value:1.07E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.23|P-value:1.76E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.16|P-value:2.67E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.06|P-value:4.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.79|P-value:7.68E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-2.95|P-value:6.29E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.84|P-value:9.14E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.95|P-value:6.10E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.94|P-value:6.33E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.26|P-value:1.81E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.92|P-value:6.69E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.97|P-value:5.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.09|P-value:3.62E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.92|P-value:6.86E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.94|P-value:6.46E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.08|P-value:3.63E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.72|P-value:2.34E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.02|P-value:4.65E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-2.88|P-value:8.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.87|P-value:1.07E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.23|P-value:1.76E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.16|P-value:2.67E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.06|P-value:4.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.79|P-value:7.68E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-2.95|P-value:6.29E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.84|P-value:9.14E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.95|P-value:6.10E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.94|P-value:6.33E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.26|P-value:1.81E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.92|P-value:6.69E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.97|P-value:5.60E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.09|P-value:3.62E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.92|P-value:6.86E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.94|P-value:6.46E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.08|P-value:3.63E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.72|P-value:2.34E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.02|P-value:4.65E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-2.88|P-value:8.06E-4

Top fitness defect scores for YBL081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 3.87 9.0 µM 1.07E-5 cell wall 382 5.36E-5
2 SGTC_2491 paeonol 3.08 100.0 µM 3.63E-4 22 0.00104
3 SGTC_2794 7785382 3.02 27.3 µM 4.65E-4 93 0.00128
4 SGTC_1715 st032160 2.97 10.2 µM 5.60E-4 90 0.00150
5 SGTC_1034 k072-0165 2.95 12.7 µM 6.10E-4 Golgi 72 0.00161
6 SGTC_2629 bisabolol 2.94 100.0 µM 6.25E-4 73 0.00164
7 SGTC_1712 st032288 2.92 53.4 µM 6.69E-4 calcium & mitochondrial duress 277 0.00174
8 SGTC_2126 5251174 2.92 33.9 µM 6.86E-4 105 0.00177
9 SGTC_968 1309-0633 2.84 340.0 µM 9.14E-4 59 0.00226
10 SGTC_268 camptothecin 2.77 39.6 µM 0.00120 DNA damage response 177 0.00284
11 SGTC_1784 st039334 2.76 36.3 µM 0.00125 83 0.00293
12 SGTC_634 1611-4317 2.75 11.2 µM 0.00127 ERG2 78 0.00298
13 SGTC_2411 st077133 2.72 39.9 µM 0.00143 RNA pol III & RNase P/MRP 124 0.00329
14 SGTC_534 k292-0788 2.66 63.4 µM 0.00173 mitochondrial processes 94 0.00386
15 SGTC_863 0466-0191 2.62 129.0 µM 0.00198 cell wall 150 0.00433
16 SGTC_433 pimozide 2.61 108.0 µM 0.00210 71 0.00455
17 SGTC_304 1310-0298 2.52 97.0 µM 0.00279 cell wall 178 0.00580
18 SGTC_2564 betulinic acid 2.49 100.0 µM 0.00318 153 0.00646
19 SGTC_1703 st026983 2.45 48.3 µM 0.00353 109 0.00707
20 SGTC_1043 0916-0009 2.42 19.3 µM 0.00398 142 0.00782

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.311 8.82E-76 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.283 1.32E-62 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.265 1.28E-54 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.264 1.71E-54 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.239 1.64E-44 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.233 2.19E-42 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.232 4.87E-42 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.232 4.93E-42 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.214 8.60E-36 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.213 1.07E-35 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.211 5.12E-35 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.211 5.91E-35 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.203 2.67E-32 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.197 1.66E-30 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.195 5.24E-30 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria