YBL087C / RPL23A

Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL087C / RPL23A

Click on Significant Values for Screen Details ID:SGTC_156|Compound:3474-0145|FD-Score:-3.04|P-value:4.52E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.71|P-value:4.81E-7 ID:SGTC_622|Compound:1348-1566|FD-Score:4.07|P-value:1.22E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.45|P-value:8.92E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.12|P-value:4.05E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-4.39|P-value:1.03E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.63|P-value:4.05E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.09|P-value:7.32E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.73|P-value:1.63E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.29|P-value:1.73E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.20|P-value:6.53E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.28|P-value:1.76E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.68|P-value:7.01E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-4.35|P-value:1.30E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.03|P-value:9.07E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.07|P-value:7.97E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.16|P-value:5.77E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.79|P-value:3.21E-7 ID:SGTC_1931|Compound:st074438|FD-Score:-3.59|P-value:4.89E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.02|P-value:4.99E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.19|P-value:5.13E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.53|P-value:4.11E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.55|P-value:3.62E-12 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.43|P-value:2.03E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.99|P-value:7.77E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.30|P-value:3.29E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-9.74|P-value:1.00E-25 ID:SGTC_2781|Compound:5567276|FD-Score:-3.90|P-value:1.19E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.03|P-value:4.66E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.68|P-value:2.11E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-2.96|P-value:6.24E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.64|P-value:3.96E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-5.95|P-value:7.87E-11 ID:SGTC_2936|Compound:9038235|FD-Score:-3.08|P-value:3.87E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.10|P-value:3.58E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.02|P-value:4.95E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.91|P-value:2.60E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.47|P-value:8.01E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.30|P-value:3.36E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-4.07|P-value:5.28E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-3.36|P-value:1.29E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.04|P-value:4.52E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.71|P-value:4.81E-7 ID:SGTC_622|Compound:1348-1566|FD-Score:4.07|P-value:1.22E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.45|P-value:8.92E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.12|P-value:4.05E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-4.39|P-value:1.03E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.63|P-value:4.05E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.09|P-value:7.32E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.73|P-value:1.63E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.29|P-value:1.73E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.20|P-value:6.53E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.28|P-value:1.76E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.68|P-value:7.01E-5 ID:SGTC_1735|Compound:st034310|FD-Score:-4.35|P-value:1.30E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.03|P-value:9.07E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.07|P-value:7.97E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.16|P-value:5.77E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.79|P-value:3.21E-7 ID:SGTC_1931|Compound:st074438|FD-Score:-3.59|P-value:4.89E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.02|P-value:4.99E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.19|P-value:5.13E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.53|P-value:4.11E-9 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.55|P-value:3.62E-12 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.43|P-value:2.03E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.99|P-value:7.77E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.30|P-value:3.29E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-9.74|P-value:1.00E-25 ID:SGTC_2781|Compound:5567276|FD-Score:-3.90|P-value:1.19E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.03|P-value:4.66E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.68|P-value:2.11E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-2.96|P-value:6.24E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.64|P-value:3.96E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-5.95|P-value:7.87E-11 ID:SGTC_2936|Compound:9038235|FD-Score:-3.08|P-value:3.87E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.10|P-value:3.58E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.02|P-value:4.95E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.91|P-value:2.60E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-3.47|P-value:8.01E-5 ID:SGTC_3265|Compound:9137266|FD-Score:3.30|P-value:3.36E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-4.07|P-value:5.28E-6 ID:SGTC_3321|Compound:9137793|FD-Score:-3.36|P-value:1.29E-4

Top fitness defect scores for YBL087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 6.55 3.5 µM 3.62E-12 24 2.78E-11
2 SGTC_2282 7944268 5.53 200.0 µM 4.11E-9 RPP1 & pyrimidine depletion 9 1.62E-8
3 SGTC_1906 st060206 4.79 94.7 µM 3.21E-7 11 8.51E-7
4 SGTC_579 4491-1009 4.71 110.0 µM 4.81E-7 60S ribosome export 10 1.23E-6
5 SGTC_1414 3917-0015 4.20 5.4 µM 6.53E-6 8 1.32E-5
6 SGTC_622 1348-1566 4.07 26.3 µM 1.22E-5 17 2.35E-5
7 SGTC_3151 9099821 3.91 49.5 µM 2.60E-5 25 4.68E-5
8 SGTC_1189 1431-2119 3.89 7.3 µM 2.76E-5 32 4.94E-5
9 SGTC_1564 D-Arginine 3.68 115.0 µM 7.01E-5 35 1.16E-4
10 SGTC_2783 7738165 3.59 71.4 µM 1.01E-4 41 1.63E-4
11 SGTC_2407 paclitaxel 3.43 400.0 µM 2.03E-4 54 3.07E-4
12 SGTC_264 promethazine 3.35 12.5 mM 2.76E-4 DNA intercalators 88 4.07E-4
13 SGTC_2571 chrysanthemic acid 3.30 100.0 µM 3.29E-4 46 4.79E-4
14 SGTC_3265 9137266 3.30 49.5 µM 3.36E-4 24 4.87E-4
15 SGTC_561 1550-0330 3.26 72.9 µM 3.91E-4 30 5.60E-4
16 SGTC_2053 5265679 3.19 138.0 µM 5.13E-4 60 7.19E-4
17 SGTC_1042 0350-0096 3.19 82.0 µM 5.14E-4 TSC3-RPN4 52 7.21E-4
18 SGTC_1903 st060211 3.16 78.3 µM 5.77E-4 60 8.02E-4
19 SGTC_1281 0884-0031 3.09 11.8 µM 7.32E-4 fatty acid desaturase (OLE1) 60 9.97E-4
20 SGTC_1847 st056231 3.07 15.0 µM 7.97E-4 88 0.00108

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 2.62E-34 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.209 2.94E-34 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.208 1.07E-33 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.170 6.71E-23 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.138 1.33E-15 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.117 1.23E-11 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.108 3.91E-10 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.108 4.08E-10 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.104 1.77E-9 YJL115W ASF1 hom Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.102 3.16E-9 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.102 4.27E-9 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.093 8.25E-8 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.090 1.84E-7 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.088 3.61E-7 YGR283C YGR283C hom Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
0.085 7.92E-7 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85