YBL089W / AVT5

Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL089W / AVT5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.70|P-value:2.02E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.39|P-value:5.87E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.88|P-value:6.26E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.29|P-value:8.10E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.80|P-value:1.41E-4 ID:SGTC_271|Compound:rotenone|FD-Score:6.17|P-value:4.08E-9 ID:SGTC_381|Compound:3461-2219|FD-Score:3.76|P-value:2.41E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.27|P-value:8.70E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.32|P-value:7.30E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.51|P-value:3.89E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:4.25|P-value:3.79E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:5.82|P-value:2.73E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.57|P-value:4.69E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.00|P-value:9.88E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.24|P-value:3.96E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.55|P-value:1.12E-5 ID:SGTC_1720|Compound:st037298|FD-Score:4.94|P-value:2.09E-6 ID:SGTC_1783|Compound:st039459|FD-Score:4.29|P-value:3.33E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.82|P-value:1.91E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:6.34E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.86|P-value:2.93E-6 ID:SGTC_2293|Compound:7624732|FD-Score:4.69|P-value:6.23E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.23|P-value:9.90E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.90|P-value:1.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.68|P-value:3.16E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-3.29|P-value:8.03E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.10|P-value:6.96E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.70|P-value:2.02E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.39|P-value:5.87E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.88|P-value:6.26E-11 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.29|P-value:8.10E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:-3.80|P-value:1.41E-4 ID:SGTC_271|Compound:rotenone|FD-Score:6.17|P-value:4.08E-9 ID:SGTC_381|Compound:3461-2219|FD-Score:3.76|P-value:2.41E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.27|P-value:8.70E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.32|P-value:7.30E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.51|P-value:3.89E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:4.25|P-value:3.79E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:5.82|P-value:2.73E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.57|P-value:4.69E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.00|P-value:9.88E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.24|P-value:3.96E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.55|P-value:1.12E-5 ID:SGTC_1720|Compound:st037298|FD-Score:4.94|P-value:2.09E-6 ID:SGTC_1783|Compound:st039459|FD-Score:4.29|P-value:3.33E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.82|P-value:1.91E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:6.34E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.86|P-value:2.93E-6 ID:SGTC_2293|Compound:7624732|FD-Score:4.69|P-value:6.23E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.23|P-value:9.90E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.90|P-value:1.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.68|P-value:3.16E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-3.29|P-value:8.03E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.10|P-value:6.96E-5

Top fitness defect scores for YBL089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_248 streptozotocin 6.88 5.2 mM 6.26E-11 DNA damage response 9 2.97E-12
2 SGTC_271 rotenone 6.17 740.0 µM 4.08E-9 2 3.35E-10
3 SGTC_1154 4088-0362 5.82 150.0 µM 2.73E-8 3 2.89E-9
4 SGTC_1720 st037298 4.94 9.5 µM 2.09E-6 24 3.93E-7
5 SGTC_2111 5486399 4.86 200.0 µM 2.93E-6 17 5.77E-7
6 SGTC_2293 7624732 4.69 200.0 µM 6.23E-6 12 1.36E-6
7 SGTC_1631 benzylvanillin 4.55 81.9 µM 1.12E-5 Golgi 17 2.65E-6
8 SGTC_58 0957-0393 4.41 9.0 µM 2.01E-5 cell wall 333 5.13E-6
9 SGTC_1783 st039459 4.29 87.5 µM 3.33E-5 Golgi 19 9.07E-6
10 SGTC_759 3486-0358 4.25 89.3 µM 3.79E-5 16 1.05E-5
11 SGTC_1319 1306-0155 4.24 43.7 µM 3.96E-5 16 1.10E-5
12 SGTC_1842 st055362 4.12 61.2 µM 6.34E-5 12 1.88E-5
13 SGTC_2930 9013230 4.10 14.9 µM 6.96E-5 heme biosynthesis & mitochondrial translocase 30 2.09E-5
14 SGTC_1245 0418-0076 4.00 17.2 µM 9.88E-5 ERG2 31 3.11E-5
15 SGTC_2500 5-alpha-androstan-3,17-dione 3.90 61.4 µM 1.47E-4 41 4.87E-5
16 SGTC_1831 st055328 3.82 12.0 µM 1.91E-4 heme biosynthesis & mitochondrial translocase 31 6.57E-5
17 SGTC_381 3461-2219 3.76 42.7 µM 2.41E-4 copper-dependent oxidative stress 21 8.55E-5
18 SGTC_2780 5215298 3.68 71.4 µM 3.16E-4 47 1.16E-4
19 SGTC_1155 4088-0394 3.57 48.2 µM 4.69E-4 45 1.82E-4
20 SGTC_1011 4112-3381 3.51 17.4 µM 5.67E-4 60 2.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.91E-17 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.123 7.83E-13 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.122 1.34E-12 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.116 1.84E-11 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.114 3.10E-11 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.114 3.78E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.111 1.21E-10 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.110 1.54E-10 YOR251C TUM1 hom Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
0.109 2.17E-10 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.109 2.72E-10 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.105 1.25E-9 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.102 2.95E-9 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.099 7.76E-9 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.099 8.49E-9 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.099 9.13E-9 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress