YBL103C / RTG3

Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL103C / RTG3

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.11|P-value:6.36E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.01|P-value:9.14E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.30|P-value:3.16E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.26|P-value:4.99E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.84|P-value:2.59E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.03|P-value:8.30E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.07|P-value:7.26E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.95|P-value:2.15E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:2.99|P-value:9.76E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.27|P-value:4.71E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.61|P-value:8.68E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:4.36|P-value:3.12E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:8.02|P-value:4.67E-17 ID:SGTC_965|Compound:1291-5240|FD-Score:8.39|P-value:1.72E-18 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.25|P-value:5.20E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:1.54E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.44|P-value:8.53E-9 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.85|P-value:2.51E-7 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:2.48E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.66|P-value:2.29E-9 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.03|P-value:8.50E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.99|P-value:9.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.04|P-value:8.11E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.26|P-value:3.58E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.51|P-value:1.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.40|P-value:1.57E-18 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.95|P-value:2.11E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.19|P-value:7.01E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.16|P-value:5.24E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.07|P-value:7.45E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.86|P-value:3.14E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.94|P-value:2.23E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-3.07|P-value:7.19E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.76|P-value:3.99E-7 ID:SGTC_2457|Compound:5731572|FD-Score:4.33|P-value:3.67E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:5.38E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:2.82E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.57|P-value:1.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.79|P-value:4.35E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.03|P-value:8.41E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.30|P-value:3.13E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.98|P-value:9.95E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.05|P-value:7.79E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.11|P-value:6.36E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.01|P-value:9.14E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.30|P-value:3.16E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.26|P-value:4.99E-6 ID:SGTC_393|Compound:acivicin|FD-Score:4.84|P-value:2.59E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.03|P-value:8.30E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.07|P-value:7.26E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.95|P-value:2.15E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:2.99|P-value:9.76E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.27|P-value:4.71E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.61|P-value:8.68E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:4.36|P-value:3.12E-6 ID:SGTC_894|Compound:0960-0238|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:8.02|P-value:4.67E-17 ID:SGTC_965|Compound:1291-5240|FD-Score:8.39|P-value:1.72E-18 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.13|P-value:5.86E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.25|P-value:5.20E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:1.54E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:5.44|P-value:8.53E-9 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.85|P-value:2.51E-7 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:2.48E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.66|P-value:2.29E-9 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.03|P-value:8.50E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.99|P-value:9.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.04|P-value:8.11E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.26|P-value:3.58E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.51|P-value:1.35E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.40|P-value:1.57E-18 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.95|P-value:2.11E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.19|P-value:7.01E-6 ID:SGTC_2013|Compound:4024628|FD-Score:3.16|P-value:5.24E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.07|P-value:7.45E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.86|P-value:3.14E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.94|P-value:2.23E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-3.07|P-value:7.19E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.76|P-value:3.99E-7 ID:SGTC_2457|Compound:5731572|FD-Score:4.33|P-value:3.67E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:5.38E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.89|P-value:2.82E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.57|P-value:1.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.79|P-value:4.35E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.03|P-value:8.41E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.30|P-value:3.13E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.98|P-value:9.95E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.11|P-value:6.45E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.05|P-value:7.79E-4

Top fitness defect scores for YBL103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 8.40 4.0 nM 1.57E-18 51 2.23E-17
2 SGTC_965 1291-5240 8.39 308.0 µM 1.72E-18 1 2.43E-17
3 SGTC_902 1120-0002 8.02 2.1 µM 4.67E-17 azole & statin 9 5.26E-16
4 SGTC_1353 1498-1206 5.66 8.1 µM 2.29E-9 mitochondrial response to ROS 19 7.74E-9
5 SGTC_1310 1188-0297 5.44 994.0 nM 8.53E-9 azole & statin 11 2.64E-8
6 SGTC_1311 1190-0148 4.85 100.0 µM 2.51E-7 azole & statin 16 6.20E-7
7 SGTC_393 acivicin 4.84 6.2 µM 2.59E-7 13 6.37E-7
8 SGTC_2456 5770359 4.76 74.5 µM 3.99E-7 8 9.56E-7
9 SGTC_778 3456-2434 4.61 196.0 µM 8.68E-7 mitochondrial response to ROS 55 1.97E-6
10 SGTC_852 0418-0143 4.36 439.0 µM 3.12E-6 calcium & mitochondrial duress 53 6.52E-6
11 SGTC_2457 5731572 4.33 11.7 µM 3.67E-6 13 7.59E-6
12 SGTC_726 3448-4391 4.27 34.2 µM 4.71E-6 8 9.57E-6
13 SGTC_383 2324-0395 4.26 7.4 µM 4.99E-6 azole & statin 29 1.01E-5
14 SGTC_1206 3978-0017 4.25 132.0 µM 5.20E-6 ERG2 27 1.05E-5
15 SGTC_1877 wortmannin 3.95 25.0 µM 2.11E-5 96 3.88E-5
16 SGTC_513 4245-1575 3.95 41.7 µM 2.15E-5 unfolded protein response 117 3.96E-5
17 SGTC_2337 9009472 3.94 200.0 µM 2.23E-5 34 4.08E-5
18 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.89 70.0 µM 2.82E-5 redox potentiating 75 5.08E-5
19 SGTC_2110 5483698 3.86 200.0 µM 3.14E-5 TSC3-RPN4 23 5.63E-5
20 SGTC_2845 9003024 3.79 43.0 µM 4.35E-5 amide catabolism 50 7.64E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 7.40E-73 YGL252C RTG2 hom Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
0.266 1.71E-55 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
0.251 1.78E-49 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.222 1.03E-38 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.213 7.30E-36 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.207 1.12E-33 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.206 1.80E-33 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.185 3.26E-27 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.183 1.07E-26 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.175 2.37E-24 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.173 5.93E-24 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.170 3.60E-23 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.161 5.98E-21 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.155 1.34E-19 YPL170W DAP1 hom Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.155 1.38E-19 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA