Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR010W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.105 | 1.08E-9 | YPR006C | ICL2 | hom | 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol |
0.096 | 2.30E-8 | YNL204C | SPS18 | hom | Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation |
0.093 | 7.46E-8 | YPR007C | REC8 | hom | Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p |
0.091 | 1.14E-7 | YCR006C_d | YCR006C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.090 | 1.94E-7 | YPL212C | PUS1 | hom | tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA |
0.087 | 4.31E-7 | YLR031W_p | YLR031W_p | hom | Putative protein of unknown function |
0.087 | 4.94E-7 | YGR027C | RPS25A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication |
0.086 | 5.32E-7 | YPL130W | SPO19 | hom | Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation |
0.086 | 6.90E-7 | YDR381W | YRA1 | het | RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member |
0.085 | 8.82E-7 | YJR116W_p | TDA4_p | hom | Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele |
0.082 | 1.86E-6 | YOR027W | STI1 | hom | Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop |
0.078 | 6.81E-6 | YGR031W | IMO32 | hom | Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 |
0.077 | 7.27E-6 | YDL113C | ATG20 | hom | Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate |
0.076 | 1.01E-5 | YOL046C_d | YOL046C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W |
0.075 | 1.29E-5 | YOR165W | SEY1 | hom | Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 |