YBR012C_d

Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR012C / YBR012C

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:-3.48|P-value:2.93E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.42|P-value:3.71E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.19|P-value:8.11E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.06|P-value:2.78E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.47|P-value:3.07E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.42|P-value:3.71E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.19|P-value:7.80E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-5.15|P-value:1.83E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.90|P-value:6.01E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.23|P-value:7.15E-4 ID:SGTC_1708|Compound:st033234|FD-Score:5.61|P-value:1.29E-8 ID:SGTC_1713|Compound:st033146|FD-Score:-3.14|P-value:9.63E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.16|P-value:8.98E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.31|P-value:9.35E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.56|P-value:2.17E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.43|P-value:3.57E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.20|P-value:7.33E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.29|P-value:5.91E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.85|P-value:6.77E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-4.91|P-value:6.29E-7 ID:SGTC_2415|Compound:st077333|FD-Score:-3.26|P-value:6.51E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.38|P-value:4.29E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-4.21|P-value:1.59E-5 ID:SGTC_2551|Compound:apiole|FD-Score:-4.81|P-value:9.90E-7 ID:SGTC_2601|Compound:securinine|FD-Score:3.36|P-value:4.28E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.12|P-value:9.69E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.29|P-value:5.81E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-6.51|P-value:6.19E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.38|P-value:4.23E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.95|P-value:4.47E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.30|P-value:5.28E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.20|P-value:1.55E-5 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.33|P-value:5.13E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.36|P-value:4.61E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.84|P-value:6.78E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.41|P-value:3.59E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.33|P-value:5.11E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.48|P-value:2.93E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.42|P-value:3.71E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.19|P-value:8.11E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.06|P-value:2.78E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.47|P-value:3.07E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.42|P-value:3.71E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.19|P-value:7.80E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.35|P-value:4.47E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:-5.15|P-value:1.83E-7 ID:SGTC_1521|Compound:st012942|FD-Score:-3.90|P-value:6.01E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.23|P-value:7.15E-4 ID:SGTC_1708|Compound:st033234|FD-Score:5.61|P-value:1.29E-8 ID:SGTC_1713|Compound:st033146|FD-Score:-3.14|P-value:9.63E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.16|P-value:8.98E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.31|P-value:9.35E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.56|P-value:2.17E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-3.43|P-value:3.57E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.20|P-value:7.33E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.29|P-value:5.91E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.85|P-value:6.77E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-4.91|P-value:6.29E-7 ID:SGTC_2415|Compound:st077333|FD-Score:-3.26|P-value:6.51E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.38|P-value:4.29E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-4.21|P-value:1.59E-5 ID:SGTC_2551|Compound:apiole|FD-Score:-4.81|P-value:9.90E-7 ID:SGTC_2601|Compound:securinine|FD-Score:3.36|P-value:4.28E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.12|P-value:9.69E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.29|P-value:5.81E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-6.51|P-value:6.19E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.38|P-value:4.23E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.95|P-value:4.47E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.30|P-value:5.28E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.20|P-value:1.55E-5 ID:SGTC_2807|Compound:7945238|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.33|P-value:5.13E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.36|P-value:4.61E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.84|P-value:6.78E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.41|P-value:3.59E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.33|P-value:5.11E-4

Top fitness defect scores for YBR012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1708 st033234 5.61 31.8 µM 1.29E-8 2 9.88E-9
2 SGTC_1871 st057448 4.31 67.3 µM 9.35E-6 18 8.03E-6
3 SGTC_2806 7952793 4.20 58.4 µM 1.55E-5 15 1.35E-5
4 SGTC_2807 7945238 4.15 52.0 µM 1.87E-5 15 1.63E-5
5 SGTC_993 3909-8757 4.06 62.7 µM 2.78E-5 25 2.43E-5
6 SGTC_2775 cyproheptadine 3.95 69.6 µM 4.47E-5 18 3.95E-5
7 SGTC_2359 9039622 3.85 200.0 µM 6.77E-5 endomembrane recycling 26 6.02E-5
8 SGTC_3210 9128157 3.84 49.5 µM 6.78E-5 49 6.03E-5
9 SGTC_3049 9092223 3.80 49.5 µM 8.00E-5 27 7.13E-5
10 SGTC_2695 st077686 3.69 52.0 µM 1.26E-4 46 1.13E-4
11 SGTC_139 0099-0334 3.66 718.6 µM 1.40E-4 44 1.26E-4
12 SGTC_3244 9134489 3.41 49.5 µM 3.59E-4 37 3.29E-4
13 SGTC_2601 securinine 3.36 100.0 µM 4.28E-4 50 3.92E-4
14 SGTC_1281 0884-0031 3.35 11.8 µM 4.47E-4 fatty acid desaturase (OLE1) 45 4.10E-4
15 SGTC_2782 7736369 3.30 71.4 µM 5.28E-4 70 4.86E-4
16 SGTC_1688 st021091 3.27 57.6 µM 5.85E-4 17 5.39E-4
17 SGTC_1966 st070145 3.20 16.1 µM 7.33E-4 48 6.78E-4
18 SGTC_1178 0988-0033 3.19 191.0 µM 7.80E-4 61 7.23E-4
19 SGTC_1914 st062367 3.14 72.6 µM 8.96E-4 56 8.32E-4
20 SGTC_2610 ononetin 3.12 44.2 µM 9.69E-4 86 9.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 1.04E-7 YDL240W LRG1 hom Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
0.081 2.37E-6 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.080 3.19E-6 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.080 3.21E-6 YPR200C ARR2 hom Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.078 6.18E-6 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.074 1.72E-5 YIR033W MGA2 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.074 1.89E-5 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.071 3.51E-5 YDL083C RPS16B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.071 3.61E-5 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.071 3.67E-5 YDR408C ADE8 hom Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.071 4.02E-5 YJL160C_p YJL160C_p hom Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication
0.071 4.20E-5 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.071 4.52E-5 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.070 4.92E-5 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.068 8.18E-5 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function