YBR026C / ETR1

2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR026C / ETR1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:4.15|P-value:4.71E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:6.03|P-value:5.73E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.07|P-value:4.00E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.30|P-value:9.70E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.75|P-value:2.13E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.02|P-value:4.74E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.35|P-value:8.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.05|P-value:9.49E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.46|P-value:1.23E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:1.79E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.92|P-value:1.13E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.90|P-value:1.91E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.16|P-value:4.57E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:6.64|P-value:1.64E-10 ID:SGTC_901|Compound:1112-0062|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:5.24|P-value:3.69E-7 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.67|P-value:2.80E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.38|P-value:7.49E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.55|P-value:4.23E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.47|P-value:5.70E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.12|P-value:3.28E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.06|P-value:6.74E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.41|P-value:1.58E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.38|P-value:1.82E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.98|P-value:8.86E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.39|P-value:7.39E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.69|P-value:4.84E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.35|P-value:2.07E-5 ID:SGTC_1694|Compound:st024011|FD-Score:4.13|P-value:4.99E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.96|P-value:6.04E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.81|P-value:1.07E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.09|P-value:4.16E-9 ID:SGTC_2105|Compound:5350118|FD-Score:6.69|P-value:1.16E-10 ID:SGTC_2125|Compound:5246583|FD-Score:3.31|P-value:9.44E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.62|P-value:1.81E-10 ID:SGTC_2283|Compound:7944793|FD-Score:7.30|P-value:2.22E-12 ID:SGTC_2471|Compound:5466956|FD-Score:3.53|P-value:4.54E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-4.72|P-value:2.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.50|P-value:1.11E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.65|P-value:3.04E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.80|P-value:1.76E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.51|P-value:1.04E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.82|P-value:1.51E-6 ID:SGTC_2875|Compound:9039966|FD-Score:-3.72|P-value:1.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.99|P-value:3.61E-9 ID:SGTC_2927|Compound:9011802|FD-Score:-3.91|P-value:7.36E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.37|P-value:1.91E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.60|P-value:3.56E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.10|P-value:5.75E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:4.15|P-value:4.71E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:6.03|P-value:5.73E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:-4.07|P-value:4.00E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:3.30|P-value:9.70E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.75|P-value:2.13E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.02|P-value:4.74E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.35|P-value:8.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.05|P-value:9.49E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.70|P-value:2.52E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.46|P-value:1.23E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.39|P-value:1.79E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.92|P-value:1.13E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.90|P-value:1.91E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:4.16|P-value:4.57E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:6.64|P-value:1.64E-10 ID:SGTC_901|Compound:1112-0062|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:5.24|P-value:3.69E-7 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.67|P-value:2.80E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.38|P-value:7.49E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.55|P-value:4.23E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.47|P-value:5.70E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.12|P-value:3.28E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.06|P-value:6.74E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.41|P-value:1.58E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.38|P-value:1.82E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.98|P-value:8.86E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.39|P-value:7.39E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.69|P-value:4.84E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.35|P-value:2.07E-5 ID:SGTC_1694|Compound:st024011|FD-Score:4.13|P-value:4.99E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.96|P-value:6.04E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.81|P-value:1.07E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:6.09|P-value:4.16E-9 ID:SGTC_2105|Compound:5350118|FD-Score:6.69|P-value:1.16E-10 ID:SGTC_2125|Compound:5246583|FD-Score:3.31|P-value:9.44E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.62|P-value:1.81E-10 ID:SGTC_2283|Compound:7944793|FD-Score:7.30|P-value:2.22E-12 ID:SGTC_2471|Compound:5466956|FD-Score:3.53|P-value:4.54E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-4.72|P-value:2.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.50|P-value:1.11E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.65|P-value:3.04E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.80|P-value:1.76E-4 ID:SGTC_2837|Compound:9008476|FD-Score:4.51|P-value:1.04E-5 ID:SGTC_2868|Compound:9035608|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.82|P-value:1.51E-6 ID:SGTC_2875|Compound:9039966|FD-Score:-3.72|P-value:1.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.99|P-value:3.61E-9 ID:SGTC_2927|Compound:9011802|FD-Score:-3.91|P-value:7.36E-5 ID:SGTC_3077|Compound:9117319|FD-Score:4.37|P-value:1.91E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.60|P-value:3.56E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.10|P-value:5.75E-5

Top fitness defect scores for YBR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2283 7944793 7.30 200.0 µM 2.22E-12 2 1.39E-13
2 SGTC_2105 5350118 6.69 200.0 µM 1.16E-10 5 1.09E-11
3 SGTC_710 3448-4187 6.64 58.0 µM 1.64E-10 fatty acid desaturase (OLE1) 15 1.59E-11
4 SGTC_2129 girgensonine 6.62 121.0 µM 1.81E-10 heme biosynthesis & mitochondrial translocase 9 1.78E-11
5 SGTC_1788 fluconazole 6.09 20.0 µM 4.16E-9 azole & statin 29 5.64E-10
6 SGTC_36 0335-0881 6.03 14.2 µM 5.73E-9 ubiquinone biosynthesis & proteasome 64 8.03E-10
7 SGTC_275 trichlorophene 5.46 5.7 µM 1.23E-7 mitochondrial stress 141 2.35E-8
8 SGTC_1178 0988-0033 5.41 191.0 µM 1.58E-7 10 3.12E-8
9 SGTC_981 1488-1094 5.24 54.9 µM 3.69E-7 9 7.95E-8
10 SGTC_236 1509-0011 5.05 5.3 µM 9.49E-7 325 2.26E-7
11 SGTC_582 0987-0078 4.90 156.0 µM 1.91E-6 calcium & mitochondrial duress 36 4.89E-7
12 SGTC_1388 3346-4487 4.69 254.0 µM 4.84E-6 8 1.36E-6
13 SGTC_2837 9008476 4.51 45.5 µM 1.04E-5 20 3.18E-6
14 SGTC_2626 ethyl orsellinate 4.50 100.0 µM 1.11E-5 22 3.40E-6
15 SGTC_310 1273-0058 4.39 1.1 µM 1.79E-5 mitochondrial stress 218 5.77E-6
16 SGTC_1182 1222-0449 4.38 220.0 µM 1.82E-5 13 5.88E-6
17 SGTC_3077 9117319 4.37 49.5 µM 1.91E-5 12 6.19E-6
18 SGTC_1395 3486-0190 4.35 4.3 µM 2.07E-5 5 6.78E-6
19 SGTC_695 3505-6186 4.16 243.0 µM 4.57E-5 22 1.63E-5
20 SGTC_34 0469-0683 4.15 81.8 µM 4.71E-5 SWF1 & branched chain AA biosynthesis 23 1.68E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 1.54E-35 YJL046W AIM22 hom Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
0.203 1.31E-32 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.193 1.28E-29 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.182 2.78E-26 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.181 3.26E-26 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.180 9.63E-26 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.179 1.20E-25 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.179 1.92E-25 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
0.176 8.53E-25 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.176 1.07E-24 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.175 1.34E-24 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.174 3.32E-24 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.172 8.75E-24 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.171 2.56E-23 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.170 4.02E-23 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit