YBR044C / TCM62

Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR044C / TCM62

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:2.63|P-value:6.34E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.40|P-value:3.84E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.11|P-value:3.50E-10 ID:SGTC_67|Compound:0335-0847|FD-Score:2.71|P-value:4.64E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-5.02|P-value:2.06E-9 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.76|P-value:6.96E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-2.76|P-value:7.08E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.64|P-value:6.65E-16 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:8.55E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.81|P-value:2.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.44|P-value:1.47E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:2.84|P-value:2.59E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.56|P-value:8.44E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.68|P-value:5.18E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.52|P-value:1.41E-11 ID:SGTC_858|Compound:0438-0351|FD-Score:3.96|P-value:7.79E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:4.28|P-value:1.07E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:2.37E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.36|P-value:2.15E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.02|P-value:1.15E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.24|P-value:3.95E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.55|P-value:8.84E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.60|P-value:7.38E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.04|P-value:1.03E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-2.84|P-value:5.05E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.37|P-value:2.04E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.34|P-value:2.35E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.86|P-value:2.33E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.57|P-value:7.22E-6 ID:SGTC_1628|Compound:st004252|FD-Score:-3.01|P-value:2.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.53|P-value:9.07E-6 ID:SGTC_1702|Compound:st027038|FD-Score:2.59|P-value:7.68E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.58|P-value:1.50E-8 ID:SGTC_1985|Compound:st071382|FD-Score:2.91|P-value:1.88E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.72|P-value:3.05E-6 ID:SGTC_2004|Compound:4023728|FD-Score:2.61|P-value:6.88E-4 ID:SGTC_2193|Compound:5925765|FD-Score:2.59|P-value:7.43E-4 ID:SGTC_2215|Compound:7188065|FD-Score:2.75|P-value:3.78E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.52|P-value:2.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:2.67|P-value:5.51E-4 ID:SGTC_2286|Compound:7945697|FD-Score:2.86|P-value:2.39E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.00|P-value:1.28E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:2.61|P-value:6.85E-4 ID:SGTC_2691|Compound:st077356|FD-Score:2.83|P-value:2.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.16|P-value:5.80E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.68|P-value:5.26E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-2.97|P-value:2.83E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.79|P-value:2.10E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.82|P-value:1.73E-6 ID:SGTC_2927|Compound:9011802|FD-Score:4.13|P-value:2.83E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-2.70|P-value:9.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:2.84|P-value:2.63E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.41|P-value:1.63E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:2.63|P-value:6.34E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.40|P-value:3.84E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.11|P-value:3.50E-10 ID:SGTC_67|Compound:0335-0847|FD-Score:2.71|P-value:4.64E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-5.02|P-value:2.06E-9 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.76|P-value:6.96E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:-2.76|P-value:7.08E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.64|P-value:6.65E-16 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:8.55E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.81|P-value:2.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.44|P-value:1.47E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:2.84|P-value:2.59E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.56|P-value:8.44E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:2.68|P-value:5.18E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:5.52|P-value:1.41E-11 ID:SGTC_858|Compound:0438-0351|FD-Score:3.96|P-value:7.79E-7 ID:SGTC_936|Compound:3005-4620|FD-Score:4.28|P-value:1.07E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:2.37E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.36|P-value:2.15E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.02|P-value:1.15E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.24|P-value:3.95E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.55|P-value:8.84E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:2.60|P-value:7.38E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.04|P-value:1.03E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-2.84|P-value:5.05E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.37|P-value:2.04E-5 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.34|P-value:2.35E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.86|P-value:2.33E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.57|P-value:7.22E-6 ID:SGTC_1628|Compound:st004252|FD-Score:-3.01|P-value:2.46E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.53|P-value:9.07E-6 ID:SGTC_1702|Compound:st027038|FD-Score:2.59|P-value:7.68E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.58|P-value:1.50E-8 ID:SGTC_1985|Compound:st071382|FD-Score:2.91|P-value:1.88E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.72|P-value:3.05E-6 ID:SGTC_2004|Compound:4023728|FD-Score:2.61|P-value:6.88E-4 ID:SGTC_2193|Compound:5925765|FD-Score:2.59|P-value:7.43E-4 ID:SGTC_2215|Compound:7188065|FD-Score:2.75|P-value:3.78E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.52|P-value:2.12E-5 ID:SGTC_2282|Compound:7944268|FD-Score:2.67|P-value:5.51E-4 ID:SGTC_2286|Compound:7945697|FD-Score:2.86|P-value:2.39E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.00|P-value:1.28E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:2.61|P-value:6.85E-4 ID:SGTC_2691|Compound:st077356|FD-Score:2.83|P-value:2.73E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.16|P-value:5.80E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.68|P-value:5.26E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-2.97|P-value:2.83E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.79|P-value:2.10E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.82|P-value:1.73E-6 ID:SGTC_2927|Compound:9011802|FD-Score:4.13|P-value:2.83E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-2.70|P-value:9.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:2.84|P-value:2.63E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.41|P-value:1.63E-5

Top fitness defect scores for YBR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 6.64 4.5 µM 6.65E-16 endomembrane recycling 40 1.57E-11
2 SGTC_823 0417-1665 5.52 178.0 µM 1.41E-11 20 1.72E-8
3 SGTC_58 0957-0393 5.11 9.0 µM 3.50E-10 cell wall 273 1.65E-7
4 SGTC_1782 st039423 4.58 80.6 µM 1.50E-8 12 2.32E-6
5 SGTC_936 3005-4620 4.28 401.0 µM 1.07E-7 14 9.27E-6
6 SGTC_2927 9011802 4.13 47.9 µM 2.83E-7 25 1.83E-5
7 SGTC_858 0438-0351 3.96 2.8 µM 7.79E-7 copper-dependent oxidative stress 23 3.74E-5
8 SGTC_2866 9034245 3.82 58.4 µM 1.73E-6 10 6.57E-5
9 SGTC_2862 9027634 3.79 71.4 µM 2.10E-6 ERG2 36 7.51E-5
10 SGTC_1996 st072960 3.72 66.8 µM 3.05E-6 23 9.79E-5
11 SGTC_1505 k297-0037 3.57 20.6 µM 7.22E-6 29 1.80E-4
12 SGTC_1635 st007035 3.53 42.4 µM 9.07E-6 248 2.11E-4
13 SGTC_312 4092-0653 3.44 6.8 µM 1.47E-5 ergosterol depletion effects on membrane 107 2.96E-4
14 SGTC_3249 9135183 3.41 49.5 µM 1.63E-5 60S ribosome export 28 3.20E-4
15 SGTC_1217 1183-1422 3.37 255.0 µM 2.04E-5 27 3.74E-4
16 SGTC_1038 k292-0204 3.36 154.0 µM 2.15E-5 33 3.88E-4
17 SGTC_1228 0124-0032 3.34 52.5 µM 2.35E-5 38 4.13E-4
18 SGTC_1002 4049-0206 3.34 172.0 µM 2.37E-5 66 4.15E-4
19 SGTC_1085 doxorubicin 3.24 7.7 µM 3.95E-5 anthracycline transcription coupled DNA repair 40 5.96E-4
20 SGTC_2785 7756463 3.16 72.7 µM 5.80E-5 66 7.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 2.81E-31 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.186 1.87E-27 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.181 3.66E-26 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.180 8.99E-26 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.178 2.69E-25 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.166 3.08E-22 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.160 1.35E-20 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.150 2.15E-18 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.148 5.65E-18 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.147 1.08E-17 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.146 1.59E-17 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.145 2.57E-17 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.143 7.27E-17 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.138 1.17E-15 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.136 2.39E-15 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data