YBR050C / REG2

Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR050C / REG2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.75|P-value:8.81E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.50|P-value:3.64E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.49|P-value:4.79E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.05|P-value:3.31E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:2.96|P-value:3.86E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-2.93|P-value:5.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.42|P-value:5.15E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:2.75|P-value:8.91E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.93|P-value:5.64E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.78|P-value:7.92E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.23|P-value:1.20E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.48|P-value:3.98E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.87|P-value:5.54E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.77|P-value:9.95E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.82|P-value:7.33E-6 ID:SGTC_1768|Compound:st044301|FD-Score:-3.05|P-value:3.37E-4 ID:SGTC_1886|Compound:st057356|FD-Score:2.91|P-value:4.77E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.79|P-value:9.27E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.47|P-value:5.40E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.64|P-value:1.85E-5 ID:SGTC_2602|Compound:kawain|FD-Score:5.14|P-value:3.01E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.57|P-value:2.60E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.89|P-value:6.41E-4 ID:SGTC_2809|Compound:7964133|FD-Score:2.85|P-value:6.03E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.78|P-value:7.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-2.77|P-value:9.90E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.81|P-value:8.59E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.85|P-value:8.35E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.43|P-value:6.38E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.37|P-value:8.40E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.75|P-value:8.81E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.50|P-value:3.64E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.49|P-value:4.79E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.05|P-value:3.31E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:2.96|P-value:3.86E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-2.93|P-value:5.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.42|P-value:5.15E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:2.75|P-value:8.91E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.93|P-value:5.64E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.78|P-value:7.92E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.23|P-value:1.20E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.48|P-value:3.98E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:2.87|P-value:5.54E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.77|P-value:9.95E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.82|P-value:7.33E-6 ID:SGTC_1768|Compound:st044301|FD-Score:-3.05|P-value:3.37E-4 ID:SGTC_1886|Compound:st057356|FD-Score:2.91|P-value:4.77E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.79|P-value:9.27E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.47|P-value:5.40E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.64|P-value:1.85E-5 ID:SGTC_2602|Compound:kawain|FD-Score:5.14|P-value:3.01E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.57|P-value:2.60E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.89|P-value:6.41E-4 ID:SGTC_2809|Compound:7964133|FD-Score:2.85|P-value:6.03E-4 ID:SGTC_2899|Compound:9053889|FD-Score:2.78|P-value:7.75E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-2.77|P-value:9.90E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.81|P-value:8.59E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.85|P-value:8.35E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.43|P-value:6.38E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.37|P-value:8.40E-5

Top fitness defect scores for YBR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2602 kawain 5.14 100.0 µM 3.01E-9 7 1.39E-7
2 SGTC_1571 st070080 3.82 73.4 µM 7.33E-6 19 6.64E-5
3 SGTC_2598 perillyl alcohol 3.64 100.0 µM 1.85E-5 44 1.38E-4
4 SGTC_2707 st078556 3.57 66.6 µM 2.60E-5 17 1.81E-4
5 SGTC_41 0478-0632 3.50 82.6 µM 3.64E-5 45 2.36E-4
6 SGTC_1088 bifonazole 3.48 369.0 nM 3.98E-5 29 2.54E-4
7 SGTC_428 3448-4153 3.42 16.5 µM 5.15E-5 TSC3-RPN4 53 3.12E-4
8 SGTC_1935 st074532 3.27 41.6 µM 1.03E-4 68 5.40E-4
9 SGTC_1004 4084-0029 3.23 199.0 µM 1.20E-4 47 6.09E-4
10 SGTC_289 k017-0060 2.96 526.0 µM 3.86E-4 22 0.00154
11 SGTC_1886 st057356 2.91 49.9 µM 4.77E-4 60S ribosome export 61 0.00183
12 SGTC_1379 2144-0755 2.87 36.5 µM 5.54E-4 72 0.00206
13 SGTC_2809 7964133 2.85 13.0 µM 6.03E-4 60S ribosome export 117 0.00220
14 SGTC_2899 9053889 2.78 58.4 µM 7.75E-4 40 0.00269
15 SGTC_987 1497-1013 2.78 404.0 µM 7.92E-4 61 0.00274
16 SGTC_38 0929-0051 2.75 58.3 µM 8.81E-4 95 0.00298
17 SGTC_556 4058-0063 2.75 51.5 µM 8.91E-4 88 0.00301
18 SGTC_1894 3',6'-dihydroxyflavone 2.70 78.7 µM 0.00107 74 0.00347
19 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 2.68 63.6 µM 0.00116 127 0.00371
20 SGTC_2754 granisetron 2.67 64.0 µM 0.00119 122 0.00379

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.14E-28 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.145 3.74E-17 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.140 3.93E-16 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.139 5.34E-16 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
0.137 1.75E-15 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.132 2.01E-14 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.128 9.78E-14 YGR141W VPS62 hom Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
0.122 1.50E-12 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.118 5.81E-12 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.118 7.89E-12 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.117 1.02E-11 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.112 6.78E-11 YML066C SMA2 hom Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
0.111 1.39E-10 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.108 3.25E-10 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.107 4.34E-10 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins