YBR066C / NRG2

Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR066C / NRG2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.61|P-value:6.76E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:2.95|P-value:1.82E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:2.87|P-value:2.58E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.60|P-value:7.28E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.67|P-value:9.50E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.79|P-value:4.37E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:2.67|P-value:6.21E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.95|P-value:2.82E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.63|P-value:1.31E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.64|P-value:1.01E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.89|P-value:2.59E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:4.94E-8 ID:SGTC_619|Compound:1652-1634|FD-Score:2.93|P-value:2.00E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.58|P-value:8.07E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.22|P-value:4.96E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.18|P-value:6.10E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.27|P-value:6.59E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.27|P-value:6.62E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.65|P-value:6.71E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-2.72|P-value:7.57E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:2.66|P-value:6.33E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-2.67|P-value:9.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-2.93|P-value:3.13E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.95|P-value:2.93E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.19|P-value:5.78E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.72|P-value:6.58E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.33|P-value:4.87E-5 ID:SGTC_1757|Compound:st041620|FD-Score:2.68|P-value:5.97E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-2.76|P-value:6.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.80|P-value:3.58E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.16|P-value:2.87E-7 ID:SGTC_2342|Compound:7990637|FD-Score:-3.95|P-value:1.82E-6 ID:SGTC_2345|Compound:9052315|FD-Score:-4.82|P-value:7.60E-9 ID:SGTC_2375|Compound:9072683|FD-Score:3.28|P-value:3.82E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:1.35E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.82|P-value:2.07E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.02|P-value:1.30E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.48|P-value:2.27E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.18|P-value:6.05E-5 ID:SGTC_2910|Compound:7948405|FD-Score:2.63|P-value:7.11E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.16|P-value:1.09E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.27|P-value:3.89E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.42|P-value:3.13E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.70|P-value:8.11E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.43|P-value:1.72E-5 ID:SGTC_3336|Compound:9143619|FD-Score:2.66|P-value:6.34E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.61|P-value:6.76E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:2.95|P-value:1.82E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:2.87|P-value:2.58E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.60|P-value:7.28E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.67|P-value:9.50E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.79|P-value:4.37E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:2.67|P-value:6.21E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.95|P-value:2.82E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.63|P-value:1.31E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.64|P-value:1.01E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.89|P-value:2.59E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.43|P-value:4.94E-8 ID:SGTC_619|Compound:1652-1634|FD-Score:2.93|P-value:2.00E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.58|P-value:8.07E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.22|P-value:4.96E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.18|P-value:6.10E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.27|P-value:6.59E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.27|P-value:6.62E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.65|P-value:6.71E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-2.72|P-value:7.57E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:2.66|P-value:6.33E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-2.67|P-value:9.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-2.93|P-value:3.13E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.95|P-value:2.93E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.19|P-value:5.78E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.72|P-value:6.58E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.33|P-value:4.87E-5 ID:SGTC_1757|Compound:st041620|FD-Score:2.68|P-value:5.97E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-2.76|P-value:6.50E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.80|P-value:3.58E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.16|P-value:2.87E-7 ID:SGTC_2342|Compound:7990637|FD-Score:-3.95|P-value:1.82E-6 ID:SGTC_2345|Compound:9052315|FD-Score:-4.82|P-value:7.60E-9 ID:SGTC_2375|Compound:9072683|FD-Score:3.28|P-value:3.82E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:1.35E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.82|P-value:2.07E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.02|P-value:1.30E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.48|P-value:2.27E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.18|P-value:6.05E-5 ID:SGTC_2910|Compound:7948405|FD-Score:2.63|P-value:7.11E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.16|P-value:1.09E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.27|P-value:3.89E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.42|P-value:3.13E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.70|P-value:8.11E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.43|P-value:1.72E-5 ID:SGTC_3336|Compound:9143619|FD-Score:2.66|P-value:6.34E-4

Top fitness defect scores for YBR066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_431 k089-0097 4.63 107.0 µM 1.31E-8 iron homeostasis 20 1.81E-6
2 SGTC_568 1193-0097 4.43 7.5 µM 4.94E-8 ERAD & cell cycle 113 4.64E-6
3 SGTC_2248 tofa 4.16 1.1 µM 2.87E-7 sphingolipid biosynthesis & PDR1 36 1.62E-5
4 SGTC_2598 perillyl alcohol 3.82 100.0 µM 2.07E-6 37 6.59E-5
5 SGTC_41 0478-0632 3.61 82.6 µM 6.76E-6 39 1.53E-4
6 SGTC_230 MPP+ 3.60 141.7 µM 7.28E-6 24 1.61E-4
7 SGTC_653 0203-0016 3.58 55.2 µM 8.07E-6 28 1.73E-4
8 SGTC_3310 9130229 3.43 44.1 µM 1.72E-5 Golgi 45 2.97E-4
9 SGTC_2375 9072683 3.28 200.0 µM 3.82E-5 mitochondrial processes 33 5.25E-4
10 SGTC_2976 9009005 3.27 19.5 µM 3.89E-5 53 5.32E-4
11 SGTC_697 0508-1955 3.22 564.0 µM 4.96E-5 65 6.32E-4
12 SGTC_1115 galangin 3.19 695.7 nM 5.78E-5 RPP1 & pyrimidine depletion 36 7.04E-4
13 SGTC_2866 9034245 3.18 58.4 µM 6.05E-5 26 7.28E-4
14 SGTC_822 1487-0950 3.18 154.0 µM 6.10E-5 40 7.32E-4
15 SGTC_2608 thymoquinone 3.02 42.7 µM 1.30E-4 51 0.00126
16 SGTC_103 0844-0104 2.95 51.8 µM 1.82E-4 ERAD & cell cycle 209 0.00160
17 SGTC_619 1652-1634 2.93 108.0 µM 2.00E-4 PDR1 69 0.00171
18 SGTC_203 k066-0004 2.87 30.9 µM 2.58E-4 RSC & ERG11 78 0.00205
19 SGTC_1913 st060213 2.80 96.1 µM 3.58E-4 117 0.00259
20 SGTC_1757 st041620 2.68 31.8 µM 5.97E-4 100 0.00373

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 8.60E-18 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.107 4.80E-10 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.104 1.59E-9 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.102 3.15E-9 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.099 9.84E-9 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.098 1.26E-8 YJL141C YAK1 hom Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
0.097 1.94E-8 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.095 3.35E-8 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.095 4.07E-8 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.092 8.75E-8 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.091 1.32E-7 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.090 1.52E-7 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
0.088 3.64E-7 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.087 3.92E-7 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.084 1.07E-6 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)