YBR085W / AAC3

Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR085W / AAC3

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-2.87|P-value:9.73E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.71|P-value:3.25E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.88|P-value:9.54E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.23|P-value:2.51E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.03|P-value:5.40E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.14|P-value:3.60E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.97|P-value:6.41E-11 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.95|P-value:7.54E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.20|P-value:2.97E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:2.97|P-value:6.96E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.07|P-value:4.58E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.79|P-value:2.22E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:2.76E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.88|P-value:9.58E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.64|P-value:2.82E-7 ID:SGTC_1943|Compound:st076331|FD-Score:-2.96|P-value:6.93E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.62|P-value:4.79E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-3.17|P-value:3.11E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.93|P-value:8.05E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.91|P-value:1.26E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-2.90|P-value:8.84E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.70|P-value:3.45E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.64|P-value:4.32E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.32|P-value:1.70E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.06|P-value:4.86E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.59|P-value:3.83E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.67|P-value:3.92E-5 ID:SGTC_2537|Compound:larixol|FD-Score:6.16|P-value:1.62E-11 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.66|P-value:2.57E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.01|P-value:7.66E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.08|P-value:2.27E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.31|P-value:1.68E-6 ID:SGTC_2693|Compound:st077581|FD-Score:5.11|P-value:1.87E-8 ID:SGTC_2821|Compound:7996764|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.19|P-value:3.21E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.22|P-value:2.60E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.47|P-value:9.39E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.75|P-value:2.65E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.28|P-value:2.03E-4 ID:SGTC_3215|Compound:9129942|FD-Score:2.99|P-value:6.50E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.17|P-value:3.09E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.42|P-value:1.17E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-2.87|P-value:9.73E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.71|P-value:3.25E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.88|P-value:9.54E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.23|P-value:2.51E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.03|P-value:5.40E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.14|P-value:3.60E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.97|P-value:6.41E-11 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.95|P-value:7.54E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.20|P-value:2.97E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:2.97|P-value:6.96E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.07|P-value:4.58E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.79|P-value:2.22E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:2.76E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.88|P-value:9.58E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.64|P-value:2.82E-7 ID:SGTC_1943|Compound:st076331|FD-Score:-2.96|P-value:6.93E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.62|P-value:4.79E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-3.17|P-value:3.11E-4 ID:SGTC_1971|Compound:st069429|FD-Score:2.93|P-value:8.05E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.91|P-value:1.26E-5 ID:SGTC_2008|Compound:4012253|FD-Score:-2.90|P-value:8.84E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.70|P-value:3.45E-5 ID:SGTC_2016|Compound:5121758|FD-Score:-3.64|P-value:4.32E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.32|P-value:1.70E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.06|P-value:4.86E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.59|P-value:3.83E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.67|P-value:3.92E-5 ID:SGTC_2537|Compound:larixol|FD-Score:6.16|P-value:1.62E-11 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.66|P-value:2.57E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.01|P-value:7.66E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.08|P-value:2.27E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.31|P-value:1.68E-6 ID:SGTC_2693|Compound:st077581|FD-Score:5.11|P-value:1.87E-8 ID:SGTC_2821|Compound:7996764|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.19|P-value:3.21E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.22|P-value:2.60E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.47|P-value:9.39E-5 ID:SGTC_3087|Compound:9117406|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.75|P-value:2.65E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.28|P-value:2.03E-4 ID:SGTC_3215|Compound:9129942|FD-Score:2.99|P-value:6.50E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.17|P-value:3.09E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.42|P-value:1.17E-4

Top fitness defect scores for YBR085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2537 larixol 6.16 68.9 µM 1.62E-11 4 3.67E-10
2 SGTC_996 3970-0799 5.97 1.8 µM 6.41E-11 36 1.20E-9
3 SGTC_2693 st077581 5.11 40.7 µM 1.87E-8 11 1.63E-7
4 SGTC_2564 betulinic acid 5.08 100.0 µM 2.27E-8 12 1.93E-7
5 SGTC_2404 5161160 4.59 200.0 µM 3.83E-7 10 2.22E-6
6 SGTC_2565 isoliquiritigenin 4.31 100.0 µM 1.68E-6 28 7.99E-6
7 SGTC_2831 7999036 4.19 19.5 µM 3.21E-6 35 1.40E-5
8 SGTC_2539 epi(13)torulosol 4.01 80.0 µM 7.66E-6 25 2.98E-5
9 SGTC_1974 st069448 3.91 26.9 µM 1.26E-5 24 4.58E-5
10 SGTC_1131 3454-3128 3.79 32.3 µM 2.22E-5 51 7.51E-5
11 SGTC_1244 0416-0015 3.74 52.5 µM 2.76E-5 ERG2 42 9.05E-5
12 SGTC_189 3970-0742 3.71 2.1 µM 3.25E-5 9 1.04E-4
13 SGTC_2014 4013930 3.70 200.0 µM 3.45E-5 46 1.10E-4
14 SGTC_2514 salinomycin 3.67 42.7 µM 3.92E-5 58 1.23E-4
15 SGTC_3080 9117754 3.47 49.5 µM 9.39E-5 31 2.62E-4
16 SGTC_3297 9117502 3.42 71.4 µM 1.17E-4 19 3.19E-4
17 SGTC_3087 9117406 3.41 49.5 µM 1.21E-4 35 3.27E-4
18 SGTC_2821 7996764 3.35 71.4 µM 1.53E-4 64 4.01E-4
19 SGTC_417 st075190 3.31 100.0 µM 1.83E-4 25 4.69E-4
20 SGTC_2563 tomatine 3.29 8.5 µM 1.99E-4 84 5.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.294 5.42E-68 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.247 8.43E-48 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.206 1.53E-33 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.205 2.54E-33 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.196 2.99E-30 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.189 2.50E-28 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.189 3.07E-28 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.184 7.26E-27 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.181 3.81E-26 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.179 1.82E-25 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.176 1.07E-24 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.171 1.70E-23 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.167 2.02E-22 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.164 1.05E-21 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.162 3.07E-21 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions