YBR104W / YMC2

Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR104W / YMC2

Click on Significant Values for Screen Details ID:SGTC_211|Compound:3455-0679|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.85|P-value:9.94E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.42|P-value:1.02E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:2.80|P-value:8.97E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.56|P-value:5.49E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.68|P-value:3.11E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.93|P-value:7.32E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.98|P-value:5.09E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.41|P-value:7.64E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:2.99|P-value:4.47E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.09|P-value:2.82E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.53|P-value:2.62E-7 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.10|P-value:2.78E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.46|P-value:6.17E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.23|P-value:2.03E-6 ID:SGTC_1648|Compound:st011736|FD-Score:2.82|P-value:8.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.48|P-value:5.58E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-4.20|P-value:2.36E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.39|P-value:8.19E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.20|P-value:1.87E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.79|P-value:1.91E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-4.25|P-value:1.84E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-3.57|P-value:5.17E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.17|P-value:2.89E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.89|P-value:7.88E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-2.88|P-value:9.12E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.03|P-value:3.70E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.50|P-value:7.03E-5 ID:SGTC_2709|Compound:st078560|FD-Score:2.85|P-value:7.66E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.07|P-value:4.28E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.01|P-value:5.41E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.75|P-value:1.60E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-2.92|P-value:7.72E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.01|P-value:5.43E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.85|P-value:7.68E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-4.04|P-value:5.64E-6 ID:SGTC_3236|Compound:9132701|FD-Score:3.06|P-value:3.32E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.47|P-value:5.81E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:2.95|P-value:5.15E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.85|P-value:9.94E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.42|P-value:1.02E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:2.80|P-value:8.97E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.56|P-value:5.49E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.68|P-value:3.11E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.93|P-value:7.32E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.98|P-value:5.09E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.41|P-value:7.64E-5 ID:SGTC_1101|Compound:ebselen|FD-Score:2.99|P-value:4.47E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.09|P-value:2.82E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.53|P-value:2.62E-7 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.10|P-value:2.78E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.46|P-value:6.17E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.23|P-value:2.03E-6 ID:SGTC_1648|Compound:st011736|FD-Score:2.82|P-value:8.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.48|P-value:5.58E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-4.20|P-value:2.36E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.39|P-value:8.19E-5 ID:SGTC_2010|Compound:4012422|FD-Score:3.20|P-value:1.87E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.79|P-value:1.91E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-4.25|P-value:1.84E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-3.57|P-value:5.17E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-3.17|P-value:2.89E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.89|P-value:7.88E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-2.88|P-value:9.12E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.03|P-value:3.70E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.50|P-value:7.03E-5 ID:SGTC_2709|Compound:st078560|FD-Score:2.85|P-value:7.66E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.07|P-value:4.28E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.01|P-value:5.41E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.75|P-value:1.60E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-2.92|P-value:7.72E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.01|P-value:5.43E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.85|P-value:7.68E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-4.04|P-value:5.64E-6 ID:SGTC_3236|Compound:9132701|FD-Score:3.06|P-value:3.32E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.47|P-value:5.81E-5

Top fitness defect scores for YBR104W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1369 1866-0067 4.53 208.0 µM 2.62E-7 RPP1 & pyrimidine depletion 26 2.97E-6
2 SGTC_1223 0764-0573 4.09 147.0 µM 2.82E-6 17 2.12E-5
3 SGTC_534 k292-0788 3.98 63.4 µM 5.09E-6 mitochondrial processes 28 3.46E-5
4 SGTC_2429 5902844 3.89 64.4 µM 7.88E-6 27 4.97E-5
5 SGTC_2812 7970281 3.75 58.4 µM 1.60E-5 36 8.96E-5
6 SGTC_1779 st039427 3.48 55.0 µM 5.58E-5 46 2.52E-4
7 SGTC_3287 9117173 3.47 37.1 µM 5.81E-5 60S ribosome export 11 2.60E-4
8 SGTC_1432 4049-0298 3.46 68.4 µM 6.17E-5 12 2.74E-4
9 SGTC_1088 bifonazole 3.41 369.0 nM 7.64E-5 30 3.27E-4
10 SGTC_1948 st076329 3.39 66.6 µM 8.19E-5 49 3.46E-4
11 SGTC_2010 4012422 3.20 159.0 µM 1.87E-4 55 6.88E-4
12 SGTC_1396 3511-0007 3.10 98.6 µM 2.78E-4 mitochondrial processes 40 9.54E-4
13 SGTC_3236 9132701 3.06 49.5 µM 3.32E-4 TSC3-RPN4 56 0.00110
14 SGTC_2492 derrusnin 3.03 100.0 µM 3.70E-4 23 0.00121
15 SGTC_1101 ebselen 2.99 5.3 µM 4.47E-4 64 0.00142
16 SGTC_211 3455-0679 2.95 143.5 µM 5.15E-4 59 0.00159
17 SGTC_408 cantharidin 2.93 100.0 µM 5.55E-4 cell wall signaling 69 0.00169
18 SGTC_2709 st078560 2.85 56.0 µM 7.66E-4 49 0.00221
19 SGTC_2986 9022445 2.85 71.4 µM 7.68E-4 75 0.00222
20 SGTC_1648 st011736 2.82 69.8 µM 8.51E-4 PDR1 58 0.00242

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 6.53E-30 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.158 3.40E-20 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.147 1.23E-17 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.146 2.43E-17 YDR109C_p YDR109C_p hom Putative kinase
0.144 4.85E-17 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.142 1.17E-16 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.141 2.40E-16 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.135 3.35E-15 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.127 1.42E-13 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.124 5.33E-13 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.124 6.52E-13 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.122 1.12E-12 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.122 1.41E-12 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.121 2.11E-12 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.114 3.28E-11 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress