YBR116C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR116C / YBR116C

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.05|P-value:4.25E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.75|P-value:2.10E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.75|P-value:1.95E-5 ID:SGTC_499|Compound:genistein|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.18|P-value:2.49E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:5.15|P-value:8.76E-9 ID:SGTC_638|Compound:3970-0837|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.55|P-value:5.12E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.92|P-value:6.95E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.18|P-value:2.51E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.98|P-value:5.54E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.43|P-value:8.64E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.94|P-value:8.09E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.95|P-value:7.91E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.85|P-value:9.04E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.10|P-value:3.48E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.14|P-value:2.86E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.99|P-value:5.25E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.25|P-value:4.35E-9 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.50|P-value:6.41E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.84|P-value:9.21E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.82|P-value:1.42E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:1.52E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-2.91|P-value:7.28E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.04|P-value:4.35E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.15|P-value:2.80E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.07|P-value:3.79E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.90|P-value:7.66E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.07|P-value:3.82E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:2.96|P-value:5.95E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.99|P-value:6.22E-6 ID:SGTC_2998|Compound:9066762|FD-Score:3.45|P-value:7.81E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.26|P-value:1.78E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.05|P-value:4.25E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.75|P-value:2.10E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.75|P-value:1.95E-5 ID:SGTC_499|Compound:genistein|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.18|P-value:2.49E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:5.15|P-value:8.76E-9 ID:SGTC_638|Compound:3970-0837|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.55|P-value:5.12E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.92|P-value:6.95E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.18|P-value:2.51E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.98|P-value:5.54E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.43|P-value:8.64E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.94|P-value:8.09E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.95|P-value:7.91E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:2.85|P-value:9.04E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.10|P-value:3.48E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.14|P-value:2.86E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.99|P-value:5.25E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.25|P-value:4.35E-9 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.50|P-value:6.41E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.84|P-value:9.21E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.82|P-value:1.42E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:1.52E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-2.91|P-value:7.28E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.04|P-value:4.35E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.15|P-value:2.80E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.15|P-value:2.79E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.07|P-value:3.79E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.90|P-value:7.66E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.07|P-value:3.82E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:2.96|P-value:5.95E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.99|P-value:6.22E-6 ID:SGTC_2998|Compound:9066762|FD-Score:3.45|P-value:7.81E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-3.26|P-value:1.78E-4

Top fitness defect scores for YBR116C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1176 0848-0131 5.25 83.3 µM 4.35E-9 Golgi 6 7.41E-8
2 SGTC_622 1348-1566 5.15 26.3 µM 8.76E-9 4 1.33E-7
3 SGTC_1119 parthenolide 4.14 318.5 nM 2.86E-6 TSC3-RPN4 32 1.72E-5
4 SGTC_2780 5215298 3.99 71.4 µM 6.22E-6 35 3.31E-5
5 SGTC_786 4544-0069 3.94 423.0 µM 8.09E-6 29 4.13E-5
6 SGTC_1243 0416-0003 3.82 5.7 µM 1.42E-5 PDR1 35 6.64E-5
7 SGTC_358 0075-0058 3.75 9.4 µM 1.95E-5 70 8.67E-5
8 SGTC_646 4092-0839 3.55 27.3 µM 5.12E-5 plasma membrane duress 35 1.95E-4
9 SGTC_2998 9066762 3.45 71.4 µM 7.81E-5 RPP1 & pyrimidine depletion 40 2.78E-4
10 SGTC_638 3970-0837 3.30 4.1 µM 1.51E-4 70 4.85E-4
11 SGTC_503 tyrphostin 8 3.18 294.0 µM 2.49E-4 TSC3-RPN4 61 7.41E-4
12 SGTC_745 0469-0705 3.18 296.0 µM 2.51E-4 mitochondrial processes 48 7.46E-4
13 SGTC_1940 st075990 3.15 51.1 µM 2.79E-4 60S ribosome export 54 8.14E-4
14 SGTC_1715 st032160 3.15 10.2 µM 2.80E-4 76 8.18E-4
15 SGTC_1083 didemethylchlorpromazine sulfoxide 3.10 707.4 nM 3.48E-4 redox potentiating 138 9.83E-4
16 SGTC_1971 st069429 3.07 63.5 µM 3.79E-4 60S ribosome export 41 0.00106
17 SGTC_2635 hydroquinidine 3.07 100.0 µM 3.82E-4 48 0.00106
18 SGTC_1571 st070080 3.04 73.4 µM 4.35E-4 51 0.00119
19 SGTC_1170 0310-0127 2.99 64.8 µM 5.25E-4 76 0.00139
20 SGTC_2767 sibutramine 2.96 71.5 µM 5.95E-4 63 0.00155

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 5.57E-19 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.140 3.69E-16 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.127 1.28E-13 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.118 7.64E-12 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.114 3.31E-11 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 7.17E-11 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.106 7.94E-10 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.103 2.72E-9 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.097 2.07E-8 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.094 5.00E-8 YCR044C PER1 hom Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
0.094 5.46E-8 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.093 6.06E-8 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.093 6.18E-8 YNL251C NRD1 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
0.085 7.49E-7 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.084 1.06E-6 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene