YBR137W

Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR137W / YBR137W

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.30|P-value:1.12E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.06|P-value:3.22E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.86|P-value:6.84E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.79|P-value:9.26E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.27|P-value:1.31E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.20|P-value:1.71E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.86|P-value:6.86E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.79|P-value:9.28E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:2.81|P-value:8.29E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.72|P-value:6.97E-8 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-2.92|P-value:5.59E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.41|P-value:4.12E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.11|P-value:2.51E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.23|P-value:1.54E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.85|P-value:8.37E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.52|P-value:4.12E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.54|P-value:3.81E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.27|P-value:1.28E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.76|P-value:1.31E-5 ID:SGTC_1863|Compound:st057641|FD-Score:-3.11|P-value:2.59E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.15|P-value:2.11E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.64|P-value:2.37E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.32|P-value:1.04E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.85|P-value:7.25E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.86|P-value:6.91E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.89|P-value:6.29E-4 ID:SGTC_2395|Compound:5646831|FD-Score:2.91|P-value:5.82E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.88|P-value:7.19E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.85|P-value:7.38E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.93|P-value:5.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.27|P-value:1.28E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.99|P-value:4.18E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.14|P-value:2.22E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.24|P-value:1.49E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.20|P-value:1.71E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-4.13|P-value:2.02E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.09|P-value:2.75E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.30|P-value:1.12E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.06|P-value:3.22E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:2.86|P-value:6.84E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.79|P-value:9.26E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.27|P-value:1.31E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.20|P-value:1.71E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.86|P-value:6.86E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.79|P-value:9.28E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:2.81|P-value:8.29E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-4.72|P-value:6.97E-8 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-2.92|P-value:5.59E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.41|P-value:4.12E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.11|P-value:2.51E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.23|P-value:1.54E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.85|P-value:8.37E-6 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.52|P-value:4.12E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.54|P-value:3.81E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.27|P-value:1.28E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.76|P-value:1.31E-5 ID:SGTC_1863|Compound:st057641|FD-Score:-3.11|P-value:2.59E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.15|P-value:2.11E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.64|P-value:2.37E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.32|P-value:1.04E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.85|P-value:7.25E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.86|P-value:6.91E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.89|P-value:6.29E-4 ID:SGTC_2395|Compound:5646831|FD-Score:2.91|P-value:5.82E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.88|P-value:7.19E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.85|P-value:7.38E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.93|P-value:5.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.27|P-value:1.28E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.99|P-value:4.18E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.14|P-value:2.22E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.24|P-value:1.49E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.20|P-value:1.71E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-4.13|P-value:2.02E-6 ID:SGTC_2931|Compound:9014674|FD-Score:3.09|P-value:2.75E-4

Top fitness defect scores for YBR137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1114 scopoletin 4.41 1.7 µM 4.12E-7 15 5.14E-6
2 SGTC_2447 5741742 3.88 33.8 µM 7.19E-6 21 5.18E-5
3 SGTC_1184 1269-1718 3.85 139.0 µM 8.37E-6 30 5.86E-5
4 SGTC_1332 1480-0653 3.76 17.5 µM 1.31E-5 TSC3-RPN4 18 8.41E-5
5 SGTC_1923 st058458 3.64 19.1 µM 2.37E-5 43 1.36E-4
6 SGTC_1320 1313-0481 3.54 95.3 µM 3.81E-5 36 2.00E-4
7 SGTC_1280 0880-0253 3.52 10.1 µM 4.12E-5 29 2.13E-4
8 SGTC_2015 5119600 3.32 184.0 µM 1.04E-4 52 4.50E-4
9 SGTC_95 0471-0001 3.30 561.1 µM 1.12E-4 50 4.81E-4
10 SGTC_2596 sinensetin 3.27 100.0 µM 1.28E-4 61 5.34E-4
11 SGTC_1321 1326-2144 3.27 215.0 µM 1.28E-4 27 5.36E-4
12 SGTC_429 1112-0049 3.27 25.5 µM 1.31E-4 DNA damage response 64 5.45E-4
13 SGTC_2751 anetholtrithion 3.24 17.2 µM 1.49E-4 54 6.06E-4
14 SGTC_1170 0310-0127 3.23 64.8 µM 1.54E-4 54 6.20E-4
15 SGTC_664 1222-0054 3.20 14.9 µM 1.71E-4 sphingolipid biosynthesis & PDR1 63 6.76E-4
16 SGTC_2807 7945238 3.20 52.0 µM 1.71E-4 67 6.77E-4
17 SGTC_1874 staurosporine 3.15 7.6 µM 2.11E-4 cell wall signaling 58 8.03E-4
18 SGTC_2613 3',4'-dimethoxydalbergione 3.14 24.6 µM 2.22E-4 56 8.35E-4
19 SGTC_1145 3546-0597 3.11 10.2 µM 2.51E-4 mitochondrial processes 52 9.23E-4
20 SGTC_2931 9014674 3.09 55.7 µM 2.75E-4 59 9.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.71E-9 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.101 3.88E-9 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.100 5.68E-9 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.098 1.16E-8 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.096 2.26E-8 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.091 1.49E-7 YLR342W-A_p YLR342W-A_p hom Putative protein of unknown function
0.090 1.85E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.088 3.30E-7 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.085 8.77E-7 YDR063W AIM7 hom Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss
0.082 1.95E-6 YBL027W RPL19B hom Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication
0.082 2.24E-6 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.077 8.92E-6 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.076 1.05E-5 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.076 1.07E-5 YLR100W ERG27 het 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
0.073 2.21E-5 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation