Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR138C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.232 | 2.63E-42 | YOR291W | YPK9 | hom | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome |
0.172 | 1.02E-23 | YBL068W | PRS4 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication |
0.127 | 1.64E-13 | YMR215W | GAS3 | hom | Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation |
0.118 | 5.81E-12 | YBR050C | REG2 | hom | Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease |
0.114 | 3.10E-11 | YKL100C_p | YKL100C_p | hom | Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene |
0.111 | 1.20E-10 | YAL043C | PTA1 | het | Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII |
0.110 | 2.01E-10 | YGR094W | VAS1 | het | Mitochondrial and cytoplasmic valyl-tRNA synthetase |
0.108 | 3.36E-10 | YDR043C | NRG1 | hom | Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication |
0.106 | 8.68E-10 | YJR011C_p | YJR011C_p | hom | Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS |
0.105 | 9.46E-10 | YEL004W | YEA4 | hom | Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER |
0.103 | 2.42E-9 | YPR055W | SEC8 | het | Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress |
0.102 | 2.80E-9 | YER148W | SPT15 | het | TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability |
0.102 | 3.01E-9 | YGL141W | HUL5 | hom | Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD |
0.100 | 5.71E-9 | YPL246C | RBD2 | hom | Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p |
0.100 | 6.39E-9 | YBR139W | YBR139W | hom | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |