HIPHOP chemogenomics database

YBR138C_p

Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR138C / YBR138C

Click on Significant Values for Screen Details

Top fitness defect scores for YBR138C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3202	9113761	9.69	49.5 µM	2.51E-26		2	1.71E-22
2	SGTC_2439	5492030	7.10	7.2 µM	4.26E-15		1	6.24E-13
3	SGTC_57	miconazole	5.71	162.5 nM	1.99E-10	ergosterol depletion effects on membrane	11	5.81E-9
4	SGTC_563	tetrahydrosecaminediol	5.57	614.0 µM	5.07E-10	amide catabolism	4	1.29E-8
5	SGTC_865	0488-0499	5.31	301.0 µM	2.86E-9		6	5.57E-8
6	SGTC_2451	5856223	5.20	45.7 µM	5.81E-9		5	1.02E-7
7	SGTC_2441	5730946	5.05	39.1 µM	1.49E-8		7	2.26E-7
8	SGTC_65	0798-0905	4.76	35.0 µM	8.20E-8	calcium & mitochondrial duress	57	9.63E-7
9	SGTC_51	1013-0126	4.50	23.4 µM	3.63E-7		22	3.40E-6
10	SGTC_234	nsc-17383	4.19	10.7 µM	1.89E-6	ERG2	20	1.38E-5
11	SGTC_537	1334-0398	4.13	209.0 µM	2.63E-6		20	1.82E-5
12	SGTC_546	peri-Naphthalide	4.00	147.0 µM	4.95E-6	DNA damage response	18	3.11E-5
13	SGTC_1653	st012112	4.00	65.0 µM	5.07E-6		10	3.18E-5
14	SGTC_763	3453-1109	3.95	128.0 µM	6.45E-6		16	3.89E-5
15	SGTC_2691	st077356	3.90	60.2 µM	8.43E-6		29	4.89E-5
16	SGTC_56	0957-0365	3.81	83.2 µM	1.30E-5	Golgi	51	7.07E-5
17	SGTC_1232	0279-0259	3.75	161.0 µM	1.73E-5		23	9.00E-5
18	SGTC_864	0469-0573	3.69	172.0 µM	2.30E-5		27	1.14E-4
19	SGTC_2311	7694451	3.66	200.0 µM	2.60E-5		29	1.27E-4
20	SGTC_3353	9151644	3.59	39.3 µM	3.53E-5		20	1.64E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.232	2.63E-42	YOR291W	YPK9	hom	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.172	1.02E-23	YBL068W	PRS4	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.127	1.64E-13	YMR215W	GAS3	hom	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.118	5.81E-12	YBR050C	REG2	hom	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.114	3.10E-11	YKL100C_p	YKL100C_p	hom	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.111	1.20E-10	YAL043C	PTA1	het	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.110	2.01E-10	YGR094W	VAS1	het	Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.108	3.36E-10	YDR043C	NRG1	hom	Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.106	8.68E-10	YJR011C_p	YJR011C_p	hom	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.105	9.46E-10	YEL004W	YEA4	hom	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.103	2.42E-9	YPR055W	SEC8	het	Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.102	2.80E-9	YER148W	SPT15	het	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
0.102	3.01E-9	YGL141W	HUL5	hom	Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.100	5.71E-9	YPL246C	RBD2	hom	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.100	6.39E-9	YBR139W	YBR139W	hom	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner