YBR148W / YSW1

Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR148W / YSW1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.19|P-value:4.76E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.86|P-value:3.88E-8 ID:SGTC_213|Compound:1246-0773|FD-Score:3.03|P-value:3.98E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.82|P-value:8.95E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.17|P-value:2.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.78|P-value:1.48E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:2.84|P-value:8.15E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.98|P-value:5.24E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-2.86|P-value:8.96E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.28|P-value:1.44E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.15|P-value:2.44E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.45|P-value:7.78E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.07|P-value:3.36E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.13|P-value:2.66E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:4.41E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.62|P-value:3.16E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.90|P-value:8.00E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.01|P-value:4.94E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.46|P-value:5.13E-7 ID:SGTC_1523|Compound:st012844|FD-Score:3.54|P-value:4.47E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.28|P-value:1.10E-6 ID:SGTC_1748|Compound:st037455|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.04|P-value:3.84E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.20|P-value:2.13E-6 ID:SGTC_2114|Compound:5491910|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.44|P-value:8.16E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.98|P-value:5.64E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.04|P-value:4.47E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.14|P-value:2.93E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.30|P-value:1.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.00|P-value:4.52E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.86|P-value:7.60E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.55|P-value:4.22E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.52|P-value:4.91E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.80|P-value:1.30E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.39|P-value:6.09E-7 ID:SGTC_2837|Compound:9008476|FD-Score:5.94|P-value:2.67E-11 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:4.90E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.22|P-value:2.16E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.11|P-value:2.88E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.30|P-value:1.30E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.03|P-value:3.98E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.34|P-value:1.27E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.27|P-value:2.87E-9 ID:SGTC_3171|Compound:9103192|FD-Score:3.02|P-value:4.05E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.62|P-value:3.61E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.49|P-value:5.50E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.90|P-value:3.12E-8 ID:SGTC_3298|Compound:9116858|FD-Score:3.56|P-value:4.03E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.19|P-value:4.76E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.86|P-value:3.88E-8 ID:SGTC_213|Compound:1246-0773|FD-Score:3.03|P-value:3.98E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.82|P-value:8.95E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.17|P-value:2.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.78|P-value:1.48E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:2.84|P-value:8.15E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.98|P-value:5.24E-6 ID:SGTC_918|Compound:glabranin|FD-Score:-2.86|P-value:8.96E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.28|P-value:1.44E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.15|P-value:2.44E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.45|P-value:7.78E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.07|P-value:3.36E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.13|P-value:2.66E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:4.41E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.62|P-value:3.16E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.90|P-value:8.00E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.01|P-value:4.94E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-4.46|P-value:5.13E-7 ID:SGTC_1523|Compound:st012844|FD-Score:3.54|P-value:4.47E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.28|P-value:1.10E-6 ID:SGTC_1748|Compound:st037455|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.04|P-value:3.84E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.20|P-value:2.13E-6 ID:SGTC_2114|Compound:5491910|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.44|P-value:8.16E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.98|P-value:5.64E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-3.04|P-value:4.47E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.14|P-value:2.93E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.30|P-value:1.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.00|P-value:4.52E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.86|P-value:7.60E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.55|P-value:4.22E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.52|P-value:4.91E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.80|P-value:1.30E-5 ID:SGTC_2676|Compound:harmalol|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.39|P-value:6.09E-7 ID:SGTC_2837|Compound:9008476|FD-Score:5.94|P-value:2.67E-11 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:4.90E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.22|P-value:2.16E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.11|P-value:2.88E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.30|P-value:1.30E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.32|P-value:1.38E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.03|P-value:3.98E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.34|P-value:1.27E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.27|P-value:2.87E-9 ID:SGTC_3171|Compound:9103192|FD-Score:3.02|P-value:4.05E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.62|P-value:3.61E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.49|P-value:5.50E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.90|P-value:3.12E-8 ID:SGTC_3298|Compound:9116858|FD-Score:3.56|P-value:4.03E-5

Top fitness defect scores for YBR148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2837 9008476 5.94 45.5 µM 2.67E-11 6 1.41E-9
2 SGTC_3146 9095609 5.27 49.5 µM 2.87E-9 6 6.74E-8
3 SGTC_65 0798-0905 5.19 35.0 µM 4.76E-9 calcium & mitochondrial duress 49 1.02E-7
4 SGTC_3295 9122362 4.90 53.6 µM 3.12E-8 5 4.85E-7
5 SGTC_73 0327-0325 4.86 16.2 µM 3.88E-8 DNA damage response 27 5.81E-7
6 SGTC_2833 9001315 4.39 45.5 µM 6.09E-7 amide catabolism 39 5.67E-6
7 SGTC_1744 st037937 4.28 38.9 µM 1.10E-6 19 9.24E-6
8 SGTC_842 0271-0008 3.98 11.1 µM 5.24E-6 heme biosynthesis & mitochondrial translocase 19 3.38E-5
9 SGTC_1490 4089-0339 3.90 670.0 nM 8.00E-6 8 4.79E-5
10 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.80 100.0 µM 1.30E-5 23 7.16E-5
11 SGTC_536 3852-0578 3.78 10.6 µM 1.48E-5 30 8.00E-5
12 SGTC_1469 k284-2957 3.62 126.0 µM 3.16E-5 13 1.50E-4
13 SGTC_3298 9116858 3.56 71.4 µM 4.03E-5 16 1.83E-4
14 SGTC_2627 acetyl isogambogic acid 3.55 100.0 µM 4.22E-5 TSC3-RPN4 57 1.91E-4
15 SGTC_1523 st012844 3.54 44.7 µM 4.47E-5 60S ribosome export 36 2.00E-4
16 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.52 100.0 µM 4.91E-5 51 2.16E-4
17 SGTC_3293 9120939 3.49 62.0 µM 5.50E-5 33 2.37E-4
18 SGTC_2955 9076254 3.30 12.2 µM 1.30E-4 35 4.84E-4
19 SGTC_1175 0741-0056 3.28 27.6 µM 1.44E-4 49 5.28E-4
20 SGTC_2676 harmalol 3.23 100.0 µM 1.72E-4 mitochondrial processes 33 6.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 6.47E-28 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.137 1.65E-15 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.119 4.36E-12 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.115 2.64E-11 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.113 6.19E-11 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.107 5.34E-10 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.104 1.76E-9 YAL046C AIM1 hom Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
0.102 3.85E-9 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.101 4.00E-9 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 7.99E-9 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.096 2.21E-8 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.096 2.77E-8 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.095 3.90E-8 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.094 4.76E-8 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.087 4.20E-7 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress