HIPHOP chemogenomics database

YBR150C / TBS1

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR150C / TBS1

Click on Significant Values for Screen Details

Top fitness defect scores for YBR150C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1299	1079-1439	4.90	3.7 µM	3.38E-8	TSC3-RPN4	3	4.72E-7
2	SGTC_227	fluconazole	4.43	33.5 µM	5.39E-7	azole & statin	66	4.71E-6
3	SGTC_1727	st034309	4.18	9.9 µM	2.14E-6		28	1.48E-5
4	SGTC_2703	st077852	4.16	53.4 µM	2.36E-6		15	1.61E-5
5	SGTC_2691	st077356	3.98	60.2 µM	5.99E-6		27	3.49E-5
6	SGTC_2055	5235184	3.85	200.0 µM	1.10E-5	ERG2	36	5.79E-5
7	SGTC_1929	genistein trimethyl ether	3.85	50.5 µM	1.14E-5		16	5.95E-5
8	SGTC_3170	9103054	3.84	49.5 µM	1.21E-5	60S ribosome export	14	6.26E-5
9	SGTC_3304	9125678	3.83	46.1 µM	1.27E-5		55	6.51E-5
10	SGTC_2411	st077133	3.68	39.9 µM	2.52E-5	RNA pol III & RNase P/MRP	38	1.15E-4
11	SGTC_999	4022-0066	3.66	22.7 µM	2.80E-5	Golgi	57	1.26E-4
12	SGTC_3085	9117376	3.52	49.5 µM	5.27E-5		22	2.14E-4
13	SGTC_657	3534-0529	3.35	86.7 µM	1.15E-4		29	4.11E-4
14	SGTC_2023	5144124	3.34	124.0 µM	1.16E-4		39	4.13E-4
15	SGTC_1371	2421-0008	3.29	32.7 µM	1.48E-4	mitochondrial processes	72	5.05E-4
16	SGTC_2799	7812892	3.12	81.8 µM	2.91E-4	superoxide	62	8.90E-4
17	SGTC_642	0335-0876	3.10	158.0 µM	3.27E-4	ubiquinone biosynthesis & proteasome	73	9.82E-4
18	SGTC_3192	9110362	3.02	49.5 µM	4.50E-4	mitochondrial processes	40	0.00128
19	SGTC_2816	7982706	3.01	58.4 µM	4.56E-4	azole & statin	104	0.00130
20	SGTC_266	formosanin C	2.95	406.0 nM	5.78E-4	sphingolipid biosynthesis & PDR1	124	0.00158

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.137	1.38E-15	YGL155W	CDC43	het	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.134	6.06E-15	YJL195C_d	YJL195C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.127	1.37E-13	YHL012W_p	YHL012W_p	hom	Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.125	3.48E-13	YKL019W	RAM2	het	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.120	3.59E-12	YDR170C	SEC7	het	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.119	4.69E-12	YOR174W	MED4	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.111	1.07E-10	YLR229C	CDC42	het	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.109	2.93E-10	YPR176C	BET2	het	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.103	2.10E-9	YML075C	HMG1	hom	HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.099	9.74E-9	YJR041C	URB2	het	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.097	1.80E-8	YLR280C_d	YLR280C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094	5.12E-8	YLR153C	ACS2	het	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.094	5.38E-8	YLR365W_d	YLR365W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.093	7.35E-8	YLR401C	DUS3	hom	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.090	1.56E-7	YGL065C	ALG2	het	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol