HIPHOP chemogenomics database
YBR153W / RIB7 
Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YBR153W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.143 | 7.32E-17 | YML070W | DAK1 | hom | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
| 0.139 | 6.62E-16 | YOL060C | MAM3 | hom | Protein required for normal mitochondrial morphology, has similarity to hemolysins |
| 0.124 | 4.51E-13 | YGR082W | TOM20 | het | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins |
| 0.121 | 1.69E-12 | YMR199W | CLN1 | hom | G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
| 0.117 | 1.23E-11 | YBR088C | POL30 | het | Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair |
| 0.115 | 2.35E-11 | YBR259W | YBR259W | hom | Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress |
| 0.105 | 9.01E-10 | YLR117C | CLF1 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
| 0.104 | 1.50E-9 | YHR040W | BCD1 | het | Essential protein required for the accumulation of box C/D snoRNA |
| 0.104 | 1.70E-9 | YOR159C | SME1 | het | Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E |
| 0.104 | 1.72E-9 | YOR098C | NUP1 | het | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 |
| 0.103 | 2.00E-9 | YOR058C | ASE1 | hom | Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress |
| 0.102 | 3.13E-9 | YLR356W | ATG33 | hom | Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes |
| 0.101 | 3.90E-9 | YIL108W | YIL108W | hom | Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress |
| 0.101 | 4.39E-9 | YIL063C | YRB2 | het | Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential |
| 0.098 | 1.24E-8 | YKL024C | URA6 | het | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |