YBR165W / UBS1

Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR165W / UBS1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.02|P-value:2.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.70|P-value:9.05E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.13|P-value:1.33E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.79|P-value:5.79E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.68|P-value:8.78E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.53|P-value:2.18E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:3.37|P-value:4.68E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.65|P-value:1.18E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.18|P-value:1.05E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.72|P-value:8.06E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.15|P-value:1.23E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:6.84E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.01|P-value:2.44E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.15|P-value:1.35E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.85|P-value:4.41E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.73|P-value:7.28E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-2.98|P-value:2.52E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.07|P-value:1.73E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.78|P-value:5.24E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.95|P-value:2.95E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.84|P-value:4.72E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.88|P-value:3.93E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.68|P-value:9.65E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:5.52E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.76|P-value:6.05E-6 ID:SGTC_1523|Compound:st012844|FD-Score:2.90|P-value:3.91E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.97|P-value:2.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.79|P-value:6.27E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.89|P-value:3.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.35|P-value:5.34E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-2.84|P-value:4.68E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.92|P-value:2.46E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-3.57|P-value:1.64E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.73|P-value:7.42E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.15|P-value:1.34E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.05|P-value:9.82E-13 ID:SGTC_2447|Compound:5741742|FD-Score:2.68|P-value:9.51E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.73|P-value:8.02E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.66|P-value:9.76E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.98|P-value:2.82E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.27|P-value:3.68E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-2.76|P-value:6.42E-4 ID:SGTC_2810|Compound:7959871|FD-Score:2.69|P-value:9.26E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.59|P-value:1.49E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.09|P-value:1.56E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.19|P-value:1.09E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.77|P-value:5.74E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.02|P-value:2.19E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.70|P-value:9.05E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.13|P-value:1.33E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.79|P-value:5.79E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.68|P-value:8.78E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.53|P-value:2.18E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:3.37|P-value:4.68E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:3.65|P-value:1.18E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.18|P-value:1.05E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.72|P-value:8.06E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.15|P-value:1.23E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:6.84E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.01|P-value:2.44E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.15|P-value:1.35E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.85|P-value:4.41E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-2.73|P-value:7.28E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-2.98|P-value:2.52E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-3.07|P-value:1.73E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.78|P-value:5.24E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.95|P-value:2.95E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.84|P-value:4.72E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.88|P-value:3.93E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.68|P-value:9.65E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.77|P-value:5.52E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.76|P-value:6.05E-6 ID:SGTC_1523|Compound:st012844|FD-Score:2.90|P-value:3.91E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.97|P-value:2.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.79|P-value:6.27E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.89|P-value:3.80E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.35|P-value:5.34E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-2.84|P-value:4.68E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.92|P-value:2.46E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-3.57|P-value:1.64E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.73|P-value:7.42E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.15|P-value:1.34E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.05|P-value:9.82E-13 ID:SGTC_2447|Compound:5741742|FD-Score:2.68|P-value:9.51E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.73|P-value:8.02E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-2.66|P-value:9.76E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.98|P-value:2.82E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.27|P-value:3.68E-7 ID:SGTC_2792|Compound:7535235|FD-Score:-2.76|P-value:6.42E-4 ID:SGTC_2810|Compound:7959871|FD-Score:2.69|P-value:9.26E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.59|P-value:1.49E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.09|P-value:1.56E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.19|P-value:1.09E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.77|P-value:5.74E-6

Top fitness defect scores for YBR165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2780 5215298 4.27 71.4 µM 3.68E-7 29 9.67E-6
2 SGTC_337 1315-0038 3.65 354.0 µM 1.18E-5 amide catabolism 31 1.31E-4
3 SGTC_317 4495-0002 3.53 170.0 µM 2.18E-5 20 2.09E-4
4 SGTC_326 k292-0812 3.37 17.5 µM 4.68E-5 14 3.72E-4
5 SGTC_2084 5306078 3.35 60.6 µM 5.34E-5 38 4.11E-4
6 SGTC_3306 9127676 3.19 59.8 µM 1.09E-4 51 7.04E-4
7 SGTC_2390 9097792 3.15 176.6 µM 1.34E-4 43 8.25E-4
8 SGTC_912 3474-0017 3.15 2.2 µM 1.35E-4 54 8.27E-4
9 SGTC_882 0843-0131 3.01 351.0 µM 2.44E-4 53 0.00130
10 SGTC_2757 clomiphene 2.98 4.2 µM 2.82E-4 fatty acid desaturase (OLE1) 97 0.00145
11 SGTC_1579 chlormadinone acetate 2.97 49.4 µM 2.92E-4 44 0.00149
12 SGTC_1523 st012844 2.90 44.7 µM 3.91E-4 60S ribosome export 77 0.00185
13 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 2.79 67.5 µM 6.27E-4 116 0.00266
14 SGTC_2497 7-hydroxyflavone 2.73 100.0 µM 8.02E-4 81 0.00320
15 SGTC_513 4245-1575 2.72 41.7 µM 8.06E-4 unfolded protein response 226 0.00322
16 SGTC_65 0798-0905 2.70 35.0 µM 9.05E-4 calcium & mitochondrial duress 197 0.00351
17 SGTC_2810 7959871 2.69 45.5 µM 9.26E-4 copper-dependent oxidative stress 126 0.00357
18 SGTC_2447 5741742 2.68 33.8 µM 9.51E-4 103 0.00365
19 SGTC_1312 1218-2183 2.68 165.0 µM 9.65E-4 53 0.00369
20 SGTC_910 3454-3003 2.66 490.0 µM 0.00105 101 0.00393

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 2.18E-60 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.225 1.83E-39 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.218 2.28E-37 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.210 1.05E-34 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.201 8.66E-32 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.189 2.64E-28 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.188 4.55E-28 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.186 2.05E-27 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.175 1.76E-24 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.173 6.52E-24 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.171 2.53E-23 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.169 6.38E-23 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.169 6.72E-23 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.169 8.31E-23 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.169 8.12E-23 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p