YBR172C / SMY2

Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR172C / SMY2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.33|P-value:1.76E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.34|P-value:1.15E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.53|P-value:7.57E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.44|P-value:8.80E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.11|P-value:3.42E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.51|P-value:1.50E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:5.30|P-value:3.99E-9 ID:SGTC_356|Compound:1634-0012|FD-Score:3.47|P-value:7.73E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.38|P-value:1.11E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.46|P-value:8.00E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.04|P-value:5.28E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.25|P-value:2.41E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.40|P-value:1.02E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.95|P-value:8.43E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:-2.90|P-value:9.58E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.20|P-value:2.96E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.59|P-value:4.48E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.25|P-value:2.51E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.86|P-value:8.89E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.31|P-value:1.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.89|P-value:9.96E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.14|P-value:3.17E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.26|P-value:1.82E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.59|P-value:5.77E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.99|P-value:6.86E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.04|P-value:4.52E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.95|P-value:6.30E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.47|P-value:9.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.43|P-value:1.41E-12 ID:SGTC_1779|Compound:st039427|FD-Score:2.92|P-value:7.15E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.48|P-value:7.30E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.58|P-value:4.58E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.31|P-value:1.95E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.88|P-value:1.14E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:2.86|P-value:8.96E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.06|P-value:4.20E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.45|P-value:6.09E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.20|P-value:2.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.58|P-value:4.69E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.70|P-value:2.75E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.00|P-value:5.28E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.48|P-value:9.38E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.14|P-value:3.02E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.33|P-value:1.76E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.34|P-value:1.15E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.53|P-value:7.57E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:3.44|P-value:8.80E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.11|P-value:3.42E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.51|P-value:1.50E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:5.30|P-value:3.99E-9 ID:SGTC_356|Compound:1634-0012|FD-Score:3.47|P-value:7.73E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:3.38|P-value:1.11E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.46|P-value:8.00E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.04|P-value:5.28E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.25|P-value:2.41E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.40|P-value:1.02E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.95|P-value:8.43E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:-2.90|P-value:9.58E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.20|P-value:2.96E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.59|P-value:4.48E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.25|P-value:2.51E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.86|P-value:8.89E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.31|P-value:1.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.89|P-value:9.96E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.14|P-value:3.17E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.26|P-value:1.82E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.59|P-value:5.77E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.99|P-value:6.86E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.04|P-value:4.52E-4 ID:SGTC_1621|Compound:st003705|FD-Score:2.95|P-value:6.30E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.47|P-value:9.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.43|P-value:1.41E-12 ID:SGTC_1779|Compound:st039427|FD-Score:2.92|P-value:7.15E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.48|P-value:7.30E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.58|P-value:4.58E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.31|P-value:1.95E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.88|P-value:1.14E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:2.86|P-value:8.96E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.06|P-value:4.20E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.45|P-value:6.09E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.20|P-value:2.36E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.58|P-value:4.69E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.70|P-value:2.75E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.00|P-value:5.28E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.48|P-value:9.38E-5 ID:SGTC_3034|Compound:9090421|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.14|P-value:3.02E-4

Top fitness defect scores for YBR172C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1712 st032288 6.43 53.4 µM 1.41E-12 calcium & mitochondrial duress 67 6.57E-11
2 SGTC_354 2783-3500 5.30 4.9 µM 3.99E-9 cell wall 24 5.76E-8
3 SGTC_2844 9010103 4.45 26.0 µM 6.09E-7 17 4.21E-6
4 SGTC_65 0798-0905 4.34 35.0 µM 1.15E-6 calcium & mitochondrial duress 71 7.24E-6
5 SGTC_1181 1222-0449 4.14 220.0 µM 3.17E-6 23 1.72E-5
6 SGTC_436 n,n-dimethylsphingosine 4.04 3.3 µM 5.28E-6 23 2.66E-5
7 SGTC_528 3492-0019 3.95 172.0 µM 8.43E-6 calcium & mitochondrial duress 221 3.97E-5
8 SGTC_2370 9071495 3.88 200.0 µM 1.14E-5 mitochondrial processes 28 5.15E-5
9 SGTC_2916 7875993 3.70 68.8 µM 2.75E-5 35 1.09E-4
10 SGTC_941 3237-0776 3.59 460.0 µM 4.48E-5 27 1.65E-4
11 SGTC_2318 6029776 3.58 164.0 µM 4.58E-5 42 1.69E-4
12 SGTC_2896 9052656 3.58 71.4 µM 4.69E-5 endomembrane recycling 145 1.72E-4
13 SGTC_1781 st038725 3.48 66.3 µM 7.30E-5 NEO1 124 2.51E-4
14 SGTC_356 1634-0012 3.47 32.5 µM 7.73E-5 39 2.64E-4
15 SGTC_366 0181-0206 3.46 4.3 µM 8.00E-5 Golgi 62 2.71E-4
16 SGTC_201 4262-0159 3.44 12.8 µM 8.80E-5 ergosterol depletion effects on membrane 64 2.95E-4
17 SGTC_502 l-744,832 3.40 89.3 µM 1.02E-4 calcium & mitochondrial duress 49 3.34E-4
18 SGTC_357 1325-0123 3.38 420.0 µM 1.11E-4 17 3.59E-4
19 SGTC_3034 9090421 3.31 49.5 µM 1.51E-4 60S ribosome export 16 4.66E-4
20 SGTC_367 0335-0881 3.30 7.1 µM 1.56E-4 ubiquinone biosynthesis & proteasome 121 4.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.30E-41 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.227 2.60E-40 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.192 2.72E-29 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.189 2.78E-28 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.187 9.51E-28 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.161 5.40E-21 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.153 3.77E-19 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.141 1.84E-16 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.140 4.65E-16 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.133 1.03E-14 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.133 1.12E-14 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.132 1.80E-14 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.121 1.87E-12 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.119 3.74E-12 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.119 4.35E-12 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine