YBR177C / EHT1

Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR177C / EHT1

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:-3.43|P-value:2.38E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.46|P-value:1.90E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.86|P-value:3.79E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.62|P-value:1.01E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.24|P-value:6.75E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.26|P-value:4.13E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.43|P-value:2.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.28|P-value:4.23E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.72|P-value:6.73E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.01|P-value:9.96E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.36|P-value:2.78E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:4.05|P-value:1.60E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.37|P-value:2.67E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.77|P-value:5.40E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.53|P-value:1.63E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.25|P-value:4.30E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.81|P-value:4.98E-24 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.81|P-value:5.23E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.39|P-value:2.51E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.17|P-value:6.23E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.18|P-value:5.38E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.67|P-value:8.23E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.40|P-value:1.86E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.15|P-value:6.83E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.21|P-value:4.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.61|P-value:1.20E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.58|P-value:1.21E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.77|P-value:6.12E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.25|P-value:4.20E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.73|P-value:6.32E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.07|P-value:1.48E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.22|P-value:4.63E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.44|P-value:2.66E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.19|P-value:8.40E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.32|P-value:3.31E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.73|P-value:6.32E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-4.26|P-value:7.22E-6 ID:SGTC_3309|Compound:9129340|FD-Score:-6.72|P-value:3.46E-12 ID:SGTC_3329|Compound:9141233|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.43|P-value:2.38E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.46|P-value:1.90E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.86|P-value:3.79E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.62|P-value:1.01E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.24|P-value:6.75E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.26|P-value:4.13E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.43|P-value:2.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.28|P-value:4.23E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.72|P-value:6.73E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:3.01|P-value:9.96E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.36|P-value:2.78E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.02|P-value:1.85E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:4.05|P-value:1.60E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.37|P-value:2.67E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.77|P-value:5.40E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.53|P-value:1.63E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.25|P-value:4.30E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.81|P-value:4.98E-24 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.05|P-value:8.73E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.81|P-value:5.23E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.39|P-value:2.51E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.17|P-value:6.23E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.18|P-value:5.38E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.67|P-value:8.23E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.40|P-value:1.86E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.15|P-value:6.83E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.21|P-value:4.83E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-3.61|P-value:1.20E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.58|P-value:1.21E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.24|P-value:4.32E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.77|P-value:6.12E-5 ID:SGTC_2034|Compound:5197015|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.25|P-value:4.20E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.73|P-value:6.32E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.07|P-value:1.48E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.22|P-value:4.63E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.44|P-value:2.66E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.19|P-value:8.40E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.32|P-value:3.31E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.73|P-value:6.32E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-4.26|P-value:7.22E-6 ID:SGTC_3309|Compound:9129340|FD-Score:-6.72|P-value:3.46E-12 ID:SGTC_3329|Compound:9141233|FD-Score:3.21|P-value:4.89E-4

Top fitness defect scores for YBR177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 9.81 1.8 µM 4.98E-24 14 5.20E-23
2 SGTC_2593 nobiletin 4.44 86.2 µM 2.66E-6 16 4.55E-6
3 SGTC_353 1988-1175 4.24 58.3 µM 6.75E-6 unfolded protein response 21 1.11E-5
4 SGTC_2596 sinensetin 4.19 100.0 µM 8.40E-6 23 1.37E-5
5 SGTC_2313 7726885 4.07 200.0 µM 1.48E-5 RPP1 & pyrimidine depletion 31 2.35E-5
6 SGTC_762 1165-0429 4.05 115.0 µM 1.60E-5 TSC3-RPN4 13 2.53E-5
7 SGTC_758 0868-0029 4.02 16.0 µM 1.85E-5 5 2.91E-5
8 SGTC_198 3454-2873 3.86 16.2 µM 3.79E-5 60S ribosome export 13 5.76E-5
9 SGTC_869 0564-0080 3.77 44.1 µM 5.40E-5 27 8.09E-5
10 SGTC_2920 7982904 3.73 15.8 µM 6.32E-5 28 9.39E-5
11 SGTC_2277 7947813 3.73 106.9 µM 6.32E-5 RSC complex & mRNA processing 34 9.39E-5
12 SGTC_538 2922-0838 3.72 53.3 µM 6.73E-5 Golgi 36 9.98E-5
13 SGTC_1210 3013-0140 3.67 750.0 nM 8.23E-5 9 1.21E-4
14 SGTC_270 tamoxifen 3.62 5.5 µM 1.01E-4 NEO1 47 1.48E-4
15 SGTC_405 ebelactone b 3.59 50.0 µM 1.15E-4 26 1.66E-4
16 SGTC_1792 st045773 3.58 43.6 µM 1.21E-4 43 1.74E-4
17 SGTC_1885 st057546 3.47 99.9 µM 1.82E-4 29 2.58E-4
18 SGTC_153 4077-0274 3.46 519.7 µM 1.90E-4 31 2.68E-4
19 SGTC_393 acivicin 3.43 6.2 µM 2.17E-4 29 3.05E-4
20 SGTC_1113 artemisinin 3.39 1.2 µM 2.51E-4 heme biosynthesis & mitochondrial translocase 29 3.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 1.29E-82 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.257 6.53E-52 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.235 1.66E-43 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.230 1.84E-41 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.229 3.36E-41 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.206 1.46E-33 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.205 3.68E-33 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.198 7.08E-31 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.195 4.04E-30 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.180 1.03E-25 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.179 2.03E-25 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.172 9.90E-24 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.171 1.60E-23 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.165 6.41E-22 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.165 8.38E-22 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress