YBR189W / RPS9B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR189W / RPS9B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.86|P-value:2.22E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.72|P-value:7.76E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.70|P-value:7.07E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.52|P-value:2.09E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.80|P-value:2.90E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.62|P-value:6.30E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.63|P-value:2.91E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.51|P-value:4.33E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.20|P-value:3.61E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.04|P-value:1.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.63|P-value:2.84E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.61|P-value:3.10E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.97|P-value:1.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-4.73|P-value:7.51E-6 ID:SGTC_2068|Compound:5226020|FD-Score:3.63|P-value:2.84E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.85|P-value:2.22E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.63|P-value:2.88E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.40|P-value:6.23E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-5.90|P-value:3.04E-8 ID:SGTC_2478|Compound:5763493|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.27|P-value:4.91E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.38|P-value:6.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-4.93|P-value:3.21E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.90|P-value:3.14E-8 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:5.06E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.80|P-value:2.91E-6 ID:SGTC_2998|Compound:9066762|FD-Score:4.63|P-value:6.10E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.83|P-value:2.56E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:4.86|P-value:2.22E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.72|P-value:7.76E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.70|P-value:7.07E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.52|P-value:2.09E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.36|P-value:7.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.80|P-value:2.90E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.62|P-value:6.30E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.63|P-value:2.91E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.51|P-value:4.33E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.20|P-value:3.61E-5 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.04|P-value:1.12E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.63|P-value:2.84E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.61|P-value:3.10E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.97|P-value:1.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-4.73|P-value:7.51E-6 ID:SGTC_2068|Compound:5226020|FD-Score:3.63|P-value:2.84E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.85|P-value:2.22E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.63|P-value:2.88E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.40|P-value:6.23E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-5.90|P-value:3.04E-8 ID:SGTC_2478|Compound:5763493|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.27|P-value:4.91E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.38|P-value:6.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.50|P-value:1.06E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-4.93|P-value:3.21E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.90|P-value:3.14E-8 ID:SGTC_2993|Compound:9054257|FD-Score:-3.61|P-value:5.06E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.80|P-value:2.91E-6 ID:SGTC_2998|Compound:9066762|FD-Score:4.63|P-value:6.10E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.83|P-value:2.56E-6

Top fitness defect scores for YBR189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 4.97 66.3 µM 1.36E-6 NEO1 73 3.32E-7
2 SGTC_118 0083-0097 4.86 135.3 µM 2.22E-6 translation 67 5.77E-7
3 SGTC_3212 9128307 4.83 49.5 µM 2.56E-6 28 6.77E-7
4 SGTC_799 1310-0557 4.80 151.0 µM 2.90E-6 superoxide 11 7.81E-7
5 SGTC_2994 9053520 4.80 71.4 µM 2.91E-6 RPP1 & pyrimidine depletion 13 7.85E-7
6 SGTC_2998 9066762 4.63 71.4 µM 6.10E-6 RPP1 & pyrimidine depletion 12 1.81E-6
7 SGTC_800 3448-7362 4.62 155.0 µM 6.30E-6 translation 109 1.88E-6
8 SGTC_2785 7756463 4.50 72.7 µM 1.06E-5 14 3.40E-6
9 SGTC_1255 0566-0045 4.20 221.0 µM 3.61E-5 excess fatty acid 24 1.36E-5
10 SGTC_2478 5763493 3.86 32.3 µM 1.30E-4 26 5.79E-5
11 SGTC_1574 spiramycin 3.77 23.7 µM 1.79E-4 31 8.32E-5
12 SGTC_2068 5226020 3.63 147.0 µM 2.84E-4 36 1.40E-4
13 SGTC_1457 k015-0032 3.63 57.3 µM 2.84E-4 46 1.40E-4
14 SGTC_1844 rapamycin 3.63 4.0 nM 2.85E-4 185 1.40E-4
15 SGTC_2345 9052315 3.63 157.4 µM 2.88E-4 25 1.42E-4
16 SGTC_878 0828-0289 3.63 13.7 µM 2.91E-4 58 1.44E-4
17 SGTC_1466 k213-0079 3.61 57.5 µM 3.10E-4 26 1.54E-4
18 SGTC_880 0833-0487 3.51 87.2 µM 4.33E-4 mitochondrial processes 23 2.25E-4
19 SGTC_2365 9042475 3.40 200.0 µM 6.23E-4 64 3.38E-4
20 SGTC_2636 apigenin dimethyl ether 3.38 100.0 µM 6.69E-4 70 3.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 1.94E-35 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.198 5.78E-31 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.198 6.71E-31 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.191 6.37E-29 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.182 1.84E-26 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.180 8.76E-26 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.180 1.15E-25 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.177 5.39E-25 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.175 1.40E-24 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.174 3.25E-24 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.172 8.17E-24 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.161 6.70E-21 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.159 2.14E-20 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.159 2.55E-20 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.158 4.01E-20 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability