YBR194W / AIM4

Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR194W / AIM4

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.35|P-value:1.25E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.57|P-value:9.00E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.09|P-value:4.00E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.01|P-value:2.23E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.27|P-value:9.07E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.74|P-value:5.19E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.89|P-value:3.22E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.49|P-value:4.12E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.13|P-value:1.46E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.61|P-value:7.84E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.60|P-value:2.65E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.27|P-value:9.00E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.63|P-value:7.50E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.77|P-value:1.40E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.57|P-value:8.89E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.13|P-value:1.48E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.07|P-value:4.22E-6 ID:SGTC_2163|Compound:5671233|FD-Score:4.14|P-value:1.41E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.63|P-value:7.48E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.84|P-value:2.69E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.70|P-value:5.90E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-4.30|P-value:5.60E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.80|P-value:4.41E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.54|P-value:9.73E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.65|P-value:6.89E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.81|P-value:4.25E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.41|P-value:5.35E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.96|P-value:4.18E-6 ID:SGTC_3134|Compound:9127454|FD-Score:5.86|P-value:1.24E-7 ID:SGTC_3135|Compound:9127742|FD-Score:8.15|P-value:3.20E-13 ID:SGTC_3274|Compound:9138298|FD-Score:4.28|P-value:8.78E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:5.35|P-value:1.25E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:3.57|P-value:9.00E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:6.09|P-value:4.00E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.01|P-value:2.23E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.27|P-value:9.07E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.74|P-value:5.19E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.89|P-value:3.22E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.49|P-value:4.12E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.13|P-value:1.46E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.61|P-value:7.84E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.60|P-value:2.65E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:4.27|P-value:9.00E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.63|P-value:7.50E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.77|P-value:1.40E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.57|P-value:8.89E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.13|P-value:1.48E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.07|P-value:4.22E-6 ID:SGTC_2163|Compound:5671233|FD-Score:4.14|P-value:1.41E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.63|P-value:7.48E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.84|P-value:2.69E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.70|P-value:5.90E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-4.30|P-value:5.60E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.80|P-value:4.41E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.54|P-value:9.73E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.65|P-value:6.89E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.81|P-value:4.25E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.41|P-value:5.35E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.96|P-value:4.18E-6 ID:SGTC_3134|Compound:9127454|FD-Score:5.86|P-value:1.24E-7 ID:SGTC_3135|Compound:9127742|FD-Score:8.15|P-value:3.20E-13 ID:SGTC_3274|Compound:9138298|FD-Score:4.28|P-value:8.78E-5

Top fitness defect scores for YBR194W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3135 9127742 8.15 49.5 µM 3.20E-13 2 1.84E-16
2 SGTC_266 formosanin C 6.09 406.0 nM 4.00E-8 sphingolipid biosynthesis & PDR1 26 5.49E-10
3 SGTC_3134 9127454 5.86 49.5 µM 1.24E-7 3 2.31E-9
4 SGTC_8 0354-0001 5.35 70.0 µM 1.25E-6 34 4.33E-8
5 SGTC_1826 st055655 5.07 41.6 µM 4.22E-6 ERG2 23 2.03E-7
6 SGTC_1686 st019653 4.77 115.5 µM 1.40E-5 mitochondrial processes 3 9.27E-7
7 SGTC_1300 1094-0077 4.60 113.0 µM 2.65E-5 4 2.09E-6
8 SGTC_854 0422-0053 4.49 192.0 µM 4.12E-5 PDR1 8 3.65E-6
9 SGTC_3099 9120367 4.41 49.5 µM 5.35E-5 11 5.08E-6
10 SGTC_3274 9138298 4.28 49.5 µM 8.78E-5 15 9.51E-6
11 SGTC_1307 1187-1599 4.27 12.2 µM 9.00E-5 PDR1 9 9.81E-6
12 SGTC_532 1548-0774 4.27 215.0 µM 9.07E-5 13 9.91E-6
13 SGTC_2163 5671233 4.14 125.0 µM 1.41E-4 21 1.73E-5
14 SGTC_951 1171-0579 4.13 82.7 µM 1.46E-4 cell wall 69 1.80E-5
15 SGTC_1745 st081495 4.13 74.0 µM 1.48E-4 RNA processing & uracil transport 69 1.85E-5
16 SGTC_453 enantio-paf c16 4.01 10.0 µM 2.23E-4 140 3.09E-5
17 SGTC_800 3448-7362 3.89 155.0 µM 3.22E-4 translation 166 4.93E-5
18 SGTC_2806 7952793 3.81 58.4 µM 4.25E-4 25 7.00E-5
19 SGTC_2450 5739737 3.80 12.9 µM 4.41E-4 28 7.34E-5
20 SGTC_695 3505-6186 3.74 243.0 µM 5.19E-4 28 9.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.15E-26 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.119 4.09E-12 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.111 1.16E-10 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.110 1.86E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.109 2.65E-10 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.105 1.29E-9 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.102 3.28E-9 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.101 4.91E-9 YMR209C_p YMR209C_p hom Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
0.098 1.45E-8 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.097 1.71E-8 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.097 2.03E-8 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.096 2.71E-8 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.092 8.36E-8 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.091 1.21E-7 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.090 1.61E-7 YLR217W_d YLR217W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6