YBR199W / KTR4

Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR199W / KTR4

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-2.88|P-value:2.52E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.38|P-value:2.01E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-2.67|P-value:6.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.61|P-value:7.36E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.23|P-value:1.42E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:2.71|P-value:4.98E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.92|P-value:2.10E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:2.90|P-value:2.05E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.83|P-value:2.91E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.84|P-value:2.81E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.83|P-value:2.88E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.59|P-value:8.27E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.60|P-value:5.92E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:7.00|P-value:1.01E-17 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.63|P-value:5.02E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.81|P-value:1.82E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.07|P-value:9.65E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.74|P-value:4.69E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.61|P-value:7.44E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.98|P-value:1.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.53|P-value:9.75E-12 ID:SGTC_1749|Compound:st037932|FD-Score:-2.99|P-value:1.49E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.81|P-value:3.09E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.40|P-value:1.75E-5 ID:SGTC_1813|Compound:st051246|FD-Score:2.85|P-value:2.67E-4 ID:SGTC_1815|Compound:st051655|FD-Score:2.58|P-value:8.63E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.12|P-value:2.72E-7 ID:SGTC_2029|Compound:5175081|FD-Score:-2.57|P-value:9.72E-4 ID:SGTC_2057|Compound:5236571|FD-Score:2.97|P-value:1.50E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.73|P-value:4.92E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.82|P-value:3.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:2.89|P-value:2.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.15|P-value:6.54E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.58|P-value:7.64E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-2.84|P-value:2.98E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.75|P-value:4.42E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.43|P-value:1.73E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.68|P-value:6.05E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.39|P-value:1.84E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.63|P-value:5.20E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.33|P-value:8.24E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.16|P-value:6.73E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.50|P-value:1.07E-5 ID:SGTC_3306|Compound:9127676|FD-Score:2.61|P-value:7.53E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.88|P-value:1.53E-9 ID:SGTC_3317|Compound:9138495|FD-Score:-3.27|P-value:3.80E-5 ID:SGTC_3319|Compound:9138450|FD-Score:-4.10|P-value:3.56E-7 ID:SGTC_3321|Compound:9137793|FD-Score:-3.58|P-value:7.43E-6 ID:SGTC_3323|Compound:9138564|FD-Score:2.96|P-value:1.56E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.88|P-value:2.52E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.38|P-value:2.01E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-2.67|P-value:6.43E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.61|P-value:7.36E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.23|P-value:1.42E-7 ID:SGTC_676|Compound:falcarinol|FD-Score:2.71|P-value:4.98E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.92|P-value:2.10E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:2.90|P-value:2.05E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.83|P-value:2.91E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.84|P-value:2.81E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:2.83|P-value:2.88E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.59|P-value:8.27E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.60|P-value:5.92E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:7.00|P-value:1.01E-17 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.63|P-value:5.02E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.81|P-value:1.82E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.07|P-value:9.65E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:-2.74|P-value:4.69E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.61|P-value:7.44E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.98|P-value:1.59E-4 ID:SGTC_1741|Compound:st038134|FD-Score:5.53|P-value:9.75E-12 ID:SGTC_1749|Compound:st037932|FD-Score:-2.99|P-value:1.49E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.81|P-value:3.09E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.40|P-value:1.75E-5 ID:SGTC_1813|Compound:st051246|FD-Score:2.85|P-value:2.67E-4 ID:SGTC_1815|Compound:st051655|FD-Score:2.58|P-value:8.63E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.12|P-value:2.72E-7 ID:SGTC_2029|Compound:5175081|FD-Score:-2.57|P-value:9.72E-4 ID:SGTC_2057|Compound:5236571|FD-Score:2.97|P-value:1.50E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-2.73|P-value:4.92E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.82|P-value:3.04E-4 ID:SGTC_2125|Compound:5246583|FD-Score:2.89|P-value:2.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.15|P-value:6.54E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-3.58|P-value:7.64E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-2.84|P-value:2.98E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.75|P-value:4.42E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.43|P-value:1.73E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.68|P-value:6.05E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.39|P-value:1.84E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.63|P-value:5.20E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.33|P-value:8.24E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.16|P-value:6.73E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.50|P-value:1.07E-5 ID:SGTC_3306|Compound:9127676|FD-Score:2.61|P-value:7.53E-4 ID:SGTC_3313|Compound:9133968|FD-Score:4.88|P-value:1.53E-9 ID:SGTC_3317|Compound:9138495|FD-Score:-3.27|P-value:3.80E-5 ID:SGTC_3319|Compound:9138450|FD-Score:-4.10|P-value:3.56E-7 ID:SGTC_3321|Compound:9137793|FD-Score:-3.58|P-value:7.43E-6 ID:SGTC_3323|Compound:9138564|FD-Score:2.96|P-value:1.56E-4

Top fitness defect scores for YBR199W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1262 0737-0114 7.00 49.6 µM 1.01E-17 3 1.32E-12
2 SGTC_1741 st038134 5.53 10.2 µM 9.75E-12 8 1.65E-8
3 SGTC_3313 9133968 4.88 57.0 µM 1.53E-9 2 5.29E-7
4 SGTC_669 0108-0021 4.23 26.2 µM 1.42E-7 fatty acid desaturase (OLE1) 69 1.19E-5
5 SGTC_2014 4013930 4.12 200.0 µM 2.72E-7 26 1.87E-5
6 SGTC_1283 0922-0125 3.81 16.4 µM 1.82E-6 27 6.93E-5
7 SGTC_1263 0774-1208 3.63 64.8 µM 5.02E-6 57 1.40E-4
8 SGTC_2616 abietic acid 3.63 100.0 µM 5.20E-6 42 1.43E-4
9 SGTC_1257 0669-0121 3.60 16.0 µM 5.92E-6 40 1.57E-4
10 SGTC_2955 9076254 3.50 12.2 µM 1.07E-5 26 2.36E-4
11 SGTC_1811 st050069 3.40 61.5 µM 1.75E-5 14 3.32E-4
12 SGTC_2605 digitonin 3.39 300.0 nM 1.84E-5 52 3.45E-4
13 SGTC_163 1327-0036 3.38 7.5 µM 2.01E-5 152 3.66E-4
14 SGTC_2126 5251174 3.15 33.9 µM 6.54E-5 77 8.29E-4
15 SGTC_1312 1218-2183 3.07 165.0 µM 9.65E-5 27 0.00109
16 SGTC_2057 5236571 2.97 38.3 µM 1.50E-4 RPP1 & pyrimidine depletion 89 0.00148
17 SGTC_3323 9138564 2.96 53.9 µM 1.56E-4 66 0.00152
18 SGTC_687 k029-0044 2.90 34.9 µM 2.05E-4 PDR1 58 0.00184
19 SGTC_2125 5246583 2.89 200.0 µM 2.16E-4 tubulin folding & SWR complex 106 0.00191
20 SGTC_1813 st051246 2.85 8.6 µM 2.67E-4 TSC3-RPN4 42 0.00221

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 1.80E-35 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.193 1.34E-29 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.177 6.54E-25 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.167 2.48E-22 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.163 2.34E-21 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.160 8.88E-21 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.158 4.38E-20 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.150 2.88E-18 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.149 3.68E-18 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.142 1.67E-16 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.136 2.95E-15 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.129 5.49E-14 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.125 3.41E-13 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.124 4.51E-13 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.123 9.16E-13 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication