YBR205W / KTR3

Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR205W / KTR3

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:2.92|P-value:1.58E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.33|P-value:2.10E-15 ID:SGTC_396|Compound:dithiazanine|FD-Score:2.60|P-value:6.76E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.03|P-value:7.50E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.67|P-value:4.10E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.32|P-value:1.99E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.84|P-value:1.87E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:2.69|P-value:4.55E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.99|P-value:1.09E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.69|P-value:1.94E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.23|P-value:3.20E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.18|P-value:4.17E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.96|P-value:1.06E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.41|P-value:9.96E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.37|P-value:3.18E-8 ID:SGTC_1202|Compound:1988-0068|FD-Score:-2.91|P-value:1.36E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.05|P-value:2.61E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.94|P-value:1.41E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.77|P-value:3.14E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.86|P-value:2.07E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.74|P-value:2.99E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.64|P-value:5.49E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.52|P-value:9.41E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.94|P-value:5.29E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.54|P-value:8.75E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.05|P-value:8.38E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.07|P-value:6.06E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-2.88|P-value:1.53E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.56|P-value:5.39E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.23|P-value:3.20E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.74|P-value:1.84E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.10|P-value:5.14E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.74|P-value:1.86E-6 ID:SGTC_2106|Compound:5357045|FD-Score:-3.07|P-value:6.24E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.69|P-value:2.56E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.21|P-value:2.93E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.40|P-value:1.08E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-2.53|P-value:7.69E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.17|P-value:3.58E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-2.93|P-value:1.25E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:1.67E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.25|P-value:5.63E-8 ID:SGTC_2807|Compound:7945238|FD-Score:-3.11|P-value:4.87E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.54|P-value:7.35E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.92|P-value:1.58E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.33|P-value:2.10E-15 ID:SGTC_396|Compound:dithiazanine|FD-Score:2.60|P-value:6.76E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.03|P-value:7.50E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.67|P-value:4.10E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.32|P-value:1.99E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.84|P-value:1.87E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:2.69|P-value:4.55E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:2.99|P-value:1.09E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.69|P-value:1.94E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.23|P-value:3.20E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.18|P-value:4.17E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.96|P-value:1.06E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.41|P-value:9.96E-6 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.37|P-value:3.18E-8 ID:SGTC_1202|Compound:1988-0068|FD-Score:-2.91|P-value:1.36E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.05|P-value:2.61E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.94|P-value:1.41E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.77|P-value:3.14E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.86|P-value:2.07E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.74|P-value:2.99E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:2.64|P-value:5.49E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.52|P-value:9.41E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.94|P-value:5.29E-7 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.54|P-value:8.75E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.05|P-value:8.38E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.07|P-value:6.06E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:-2.88|P-value:1.53E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.56|P-value:5.39E-6 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.23|P-value:3.20E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.74|P-value:1.84E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.10|P-value:5.14E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.74|P-value:1.86E-6 ID:SGTC_2106|Compound:5357045|FD-Score:-3.07|P-value:6.24E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.69|P-value:2.56E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.21|P-value:2.93E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.40|P-value:1.08E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-2.53|P-value:7.69E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.17|P-value:3.58E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-2.93|P-value:1.25E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.35|P-value:1.67E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.25|P-value:5.63E-8 ID:SGTC_2807|Compound:7945238|FD-Score:-3.11|P-value:4.87E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.54|P-value:7.35E-4

Top fitness defect scores for YBR205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_68 0986-0284 6.33 82.8 µM 2.10E-15 16 1.22E-10
2 SGTC_1200 1643-0193 4.37 18.4 µM 3.18E-8 9 6.27E-6
3 SGTC_1257 0669-0121 4.05 16.0 µM 2.61E-7 24 2.51E-5
4 SGTC_1333 1482-0047 3.94 286.0 µM 5.29E-7 17 4.02E-5
5 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.74 70.1 µM 1.84E-6 34 9.16E-5
6 SGTC_2055 5235184 3.74 200.0 µM 1.86E-6 ERG2 43 9.24E-5
7 SGTC_2107 5363541 3.69 170.2 µM 2.56E-6 13 1.14E-4
8 SGTC_1563 conessine 3.56 56.1 µM 5.39E-6 27 1.87E-4
9 SGTC_2514 salinomycin 3.35 42.7 µM 1.67E-5 83 3.97E-4
10 SGTC_689 0833-0039 3.32 98.0 µM 1.99E-5 ergosterol depletion effects on membrane 47 4.45E-4
11 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.23 85.4 µM 3.20E-5 50 6.11E-4
12 SGTC_1022 4477-0945 3.23 21.3 µM 3.20E-5 55 6.12E-4
13 SGTC_1083 didemethylchlorpromazine sulfoxide 3.18 707.4 nM 4.17E-5 redox potentiating 133 7.29E-4
14 SGTC_1353 1498-1206 3.05 8.1 µM 8.38E-5 mitochondrial response to ROS 105 0.00116
15 SGTC_998 3996-0085 2.99 177.0 µM 1.09E-4 55 0.00139
16 SGTC_1262 0737-0114 2.94 49.6 µM 1.41E-4 71 0.00165
17 SGTC_65 0798-0905 2.92 35.0 µM 1.58E-4 calcium & mitochondrial duress 172 0.00178
18 SGTC_1270 0831-1170 2.86 17.3 µM 2.07E-4 59 0.00213
19 SGTC_1268 0828-0275 2.77 2.5 µM 3.14E-4 85 0.00282
20 SGTC_746 1095-0025 2.69 46.6 µM 4.55E-4 RSC & ERG11 75 0.00362

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.31E-22 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.160 1.14E-20 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.154 3.22E-19 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.148 6.71E-18 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.134 6.36E-15 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.130 4.73E-14 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.123 7.32E-13 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.121 2.34E-12 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.120 3.68E-12 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 8.57E-12 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
0.116 1.44E-11 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.114 3.53E-11 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.114 4.01E-11 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.114 4.35E-11 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.111 1.36E-10 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain